Millettia brandisiana
Species
KNApSAcK Entry
| Organism name | Millettia brandisiana |
|---|---|
| Genus | Millettia |
| Family | Fabaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Millettia |
|---|---|
| Linked NCBI taxonomy ID | 53625 |
| Linked level | genus |
Family
| Family in NCBI taxonomy | Fabaceae |
|---|---|
| ID | 3803 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | rosids |
|---|---|
| ID | 71275 |
Metabolite list (19)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00039903
|
Olibergin A
|
CHEMBL250269
|
No. 3 | No. 15 |
|
|||
|
C00009484
|
Robustigenin
/ 5-Hydroxy-7,2',4',5'-tetramethoxyisoflavone |
No. 8 | No. 15 |
|
||||
|
C00009596
|
Stemonal
|
No. 8 | No. 15 |
|
||||
|
C00038630
|
Brandisianin A
/ 4'-O-Prenylolibergin A |
No. 15 | No. 15 |
|
||||
|
C00038634
|
Brandisianin E
|
CHEMBL250889
|
No. 15 | No. 15 |
|
|||
|
C00009835
|
Viridiflorin
/ 5,7,4'-Trihydroxy-2',5'-dimethoxy-6-prenylisoflavone |
CHEMBL400361
|
No. 15 | No. 15 |
|
|||
|
C00038632
|
Brandisianin C
|
CHEMBL403122
|
No. 15 | No. 15 |
|
|||
|
C00038633
|
Brandisianin D
/ (-)-Brandisianin D |
CHEMBL400360
|
No. 24 | No. 15 |
|
|||
|
C00032368
|
Toxicarol isoflavone
|
No. 24 | No. 15 |
|
||||
|
C00019668
|
4'-Demethyltoxicarol
/ 5,4'-Dihydroxy-2',5'-dimethoxy-6'',6''-dimethylpyrano[2'',3'':7,8]isoflavone |
CHEMBL250439
|
No. 24 | No. 15 |
|
|||
|
C00000982
|
Naringenin
/ (-)-Naringenin |
CHEMBL9352
CHEMBL32571 |
C005273
|
57 / 46 / 40 | 35 / 10 | No. 25 | No. 14 |
|
|
C00000956
|
(-)-Epicatechin
|
CHEMBL80941
CHEMBL311498 CHEMBL129482 CHEMBL200715 CHEMBL206452 CHEMBL583912 |
85 / 58 / 54 | No. 52 | No. 14 |
|
||
|
C00003672
|
Sitosterol
/ beta-sitosterl / (-)-beta-Sitosterol / Stigmast-5-en-3beta-ol |
CHEMBL221542
CHEMBL1398443 CHEMBL1875388 |
17 / 19 / 12 | No. 53 | No. 11 |
|
||
|
C00038635
|
Brandisianin F
|
CHEMBL250890
|
No. 66 | No. 15 |
|
|||
|
C00009606
|
Villosol
/ 6a,12-Didehydrosumatrol / 6a,12a-Dehydro-alpha-toxicarol |
C048348
|
No. 236 | No. 15 |
|
|||
|
C00038631
|
Brandisianin B
/ (-)-Brandisianin B |
CHEMBL251258
|
No. 236 | No. 15 |
|
|||
|
C00019209
|
6-Deoxyclitoriacetal
|
CHEMBL1807664
|
1 / 0 / 0 | No. 583 |
|
|||
|
C00009567
|
Sermundone
|
No. 583 |
|
|||||
|
C00029676
|
alpha-Toxicarol
/ (-)-alpha-Toxicarol |
CHEMBL508992
CHEMBL1488225 |
10 / 9 / 6 | No. 589 | No. 15 |
|
Human Protein / Gene in interactions
129 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00000956 C00000982 C00003672 C00029676 | 0 / 1 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00000956 C00000982 C00003672 C00029676 | 1 / 1 |
| P18031 | Tyrosine-protein phosphatase non-receptor type 1 | Tyr | C00000956 C00000982 C00003672 | 0 / 0 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00000956 C00000982 C00003672 | 0 / 0 |
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | C00000956 C00000982 C00029676 | 0 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00000956 C00000982 C00003672 | 1 / 1 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00000956 C00000982 C00003672 | 0 / 1 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00000956 C00000982 C00003672 | 1 / 0 |
| P35372 | Mu-type opioid receptor | Opioid receptor | C00000956 C00000982 | 0 / 0 |
| P22309 | UDP-glucuronosyltransferase 1-1 | Enzyme | C00000956 C00000982 | 5 / 1 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00000956 C00000982 | 0 / 0 |
| P35354 | Prostaglandin G/H synthase 2 | Oxidoreductase | C00000956 C00000982 | 0 / 3 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00000956 C00029676 | 0 / 0 |
| P06746 | DNA polymerase beta | Enzyme | C00000956 C00003672 | 0 / 0 |
| Q16637 | Survival motor neuron protein | Unclassified protein | C00000956 C00029676 | 4 / 1 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00000956 C00029676 | 4 / 3 |
| P03372 | Estrogen receptor | NR3A1 | C00000982 C00003672 | 1 / 1 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | C00000956 C00000982 | 3 / 3 |
| P22310 | UDP-glucuronosyltransferase 1-4 | Enzyme | C00000956 C00000982 | 3 / 0 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00000956 C00029676 | 0 / 0 |
| P04745 | Alpha-amylase 1 | Enzyme | C00000956 C00000982 | 0 / 0 |
| P00734 | Prothrombin | S1A | C00000956 C00003672 | 4 / 2 |
| O00255 | Menin | Unclassified protein | C00000956 C00000982 | 2 / 5 |
| P41143 | Delta-type opioid receptor | Opioid receptor | C00000956 C00000982 | 0 / 0 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00000956 C00029676 | 0 / 0 |
| P41145 | Kappa-type opioid receptor | Opioid receptor | C00000956 C00000982 | 0 / 0 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | C00000956 C00003672 | 3 / 2 |
| P47989 | Xanthine dehydrogenase/oxidase | Oxidoreductase | C00000956 C00000982 | 1 / 1 |
| P11388 | DNA topoisomerase 2-alpha | Isomerase | C00000956 C00019209 | 0 / 0 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00000956 C00000982 | 1 / 2 |
| P08183 | Multidrug resistance protein 1 | drug | C00000982 C00003672 | 1 / 0 |
| Q9NPD5 | Solute carrier organic anion transporter family member 1B3 | Electrochemical transporter | C00000982 | 1 / 0 |
| P49327 | Fatty acid synthase | Transferase | C00000956 | 0 / 0 |
| P02768 | Serum albumin | Secreted protein | C00000956 | 0 / 0 |
| P24941 | Cyclin-dependent kinase 2 | Cdc2 | C00000982 | 0 / 0 |
| P24864 | G1/S-specific cyclin-E1 | Other cytosolic protein | C00000982 | 0 / 2 |
| O75828 | Carbonyl reductase [NADPH] 3 | Enzyme | C00000982 | 0 / 0 |
| P54132 | Bloom syndrome protein | Enzyme | C00000956 | 1 / 2 |
| P00918 | Carbonic anhydrase 2 | Lyase | C00000956 | 1 / 2 |
| P11473 | Vitamin D3 receptor | NR1I1 | C00000956 | 2 / 3 |
| P23219 | Prostaglandin G/H synthase 1 | Oxidoreductase | C00000956 | 0 / 0 |
| P08047 | Transcription factor Sp1 | Unclassified protein | C00003672 | 0 / 0 |
| P23280 | Carbonic anhydrase 6 | Lyase | C00000956 | 0 / 0 |
| Q9Y3R4 | Sialidase-2 | Enzyme | C00000956 | 0 / 0 |
| Q9ULX7 | Carbonic anhydrase 14 | Lyase | C00000956 | 0 / 0 |
| O75604 | Ubiquitin carboxyl-terminal hydrolase 2 | Enzyme | C00029676 | 0 / 0 |
| O43570 | Carbonic anhydrase 12 | Lyase | C00000956 | 1 / 2 |
| P04278 | Sex hormone-binding globulin | Secreted protein | C00000982 | 0 / 0 |
| P36888 | Receptor-type tyrosine-protein kinase FLT3 | Pdgfr | C00000982 | 1 / 1 |
| P39748 | Flap endonuclease 1 | Enzyme | C00000956 | 0 / 0 |
| P07998 | Ribonuclease pancreatic | Enzyme | C00000956 | 0 / 0 |
| P16152 | Carbonyl reductase [NADPH] 1 | Enzyme | C00000982 | 0 / 0 |
| P84022 | Mothers against decapentaplegic homolog 3 | Unclassified protein | C00000956 | 2 / 0 |
| O75496 | Geminin | Unclassified protein | C00000982 | 0 / 0 |
| P54855 | UDP-glucuronosyltransferase 2B15 | Enzyme | C00000982 | 0 / 0 |
| P62158 | Calmodulin | Unclassified protein | C00000982 | 1 / 0 |
| Q92731 | Estrogen receptor beta | NR3A2 | C00000982 | 0 / 1 |
| P15121 | Aldose reductase | Enzyme | C00000982 | 0 / 0 |
| P00915 | Carbonic anhydrase 1 | Lyase | C00000956 | 0 / 0 |
| P49841 | Glycogen synthase kinase-3 beta | Gsk | C00003672 | 0 / 0 |
| P07711 | Cathepsin L1 | C1A | C00000956 | 0 / 0 |
| Q9Y253 | DNA polymerase eta | Enzyme | C00000956 | 1 / 1 |
| P09923 | Intestinal-type alkaline phosphatase | Enzyme | C00000956 | 0 / 0 |
| P05186 | Alkaline phosphatase, tissue-nonspecific isozyme | Enzyme | C00000956 | 3 / 1 |
| P04798 | Cytochrome P450 1A1 | Cytochrome P450 1A1 | C00000982 | 0 / 0 |
| P28907 | ADP-ribosyl cyclase 1 | Enzyme | C00000956 | 0 / 1 |
| Q8N1Q1 | Carbonic anhydrase 13 | Lyase | C00000956 | 0 / 0 |
| P04150 | Glucocorticoid receptor | NR3C1 | C00000982 | 0 / 1 |
| P11511 | Cytochrome P450 19A1 | Cytochrome P450 19A1 | C00000982 | 2 / 2 |
| P14679 | Tyrosinase | Oxidoreductase | C00003672 | 4 / 2 |
| P37231 | Peroxisome proliferator-activated receptor gamma | NR1C3 | C00000982 | 5 / 3 |
| Q16678 | Cytochrome P450 1B1 | Cytochrome P450 1B1 | C00000982 | 4 / 4 |
| Q03181 | Peroxisome proliferator-activated receptor delta | NR1C2 | C00000982 | 0 / 0 |
| P18054 | Arachidonate 12-lipoxygenase, 12S-type | Enzyme | C00000982 | 2 / 0 |
| P08581 | Hepatocyte growth factor receptor | TK tyrosine-protein kinase MET subfamily | C00000956 | 2 / 3 |
| P52209 | 6-phosphogluconate dehydrogenase, decarboxylating | Enzyme | C00000956 | 0 / 0 |
| P10696 | Alkaline phosphatase, placental-like | Enzyme | C00000956 | 0 / 1 |
| P56817 | Beta-secretase 1 | A1A | C00000956 | 0 / 0 |
| P43166 | Carbonic anhydrase 7 | Lyase | C00000956 | 0 / 0 |
| Q16790 | Carbonic anhydrase 9 | Lyase | C00000956 | 0 / 1 |
| P35218 | Carbonic anhydrase 5A, mitochondrial | Lyase | C00000956 | 0 / 0 |
| Q9UNQ0 | ATP-binding cassette sub-family G member 2 | ATP binding cassette | C00000982 | 2 / 0 |
| Q92887 | Canalicular multispecific organic anion transporter 1 | Unclassified protein | C00000982 | 1 / 1 |
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | C00000956 | 2 / 2 |
| Q01453 | Peripheral myelin protein 22 | Unclassified protein | C00000956 | 5 / 2 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00029676 | 0 / 0 |
| Q9HAW9 | UDP-glucuronosyltransferase 1-8 | Enzyme | C00000982 | 0 / 0 |
| O76074 | cGMP-specific 3',5'-cyclic phosphodiesterase | PDE_5A | C00000982 | 0 / 0 |
| P00374 | Dihydrofolate reductase | Oxidoreductase | C00000956 | 1 / 1 |
| Q9Y2D0 | Carbonic anhydrase 5B, mitochondrial | Lyase | C00000956 | 0 / 0 |
| P22303 | Acetylcholinesterase | Hydrolase | C00000982 | 1 / 0 |
| P10253 | Lysosomal alpha-glucosidase | Hydrolase | C00000956 | 1 / 1 |
| P19838 | Nuclear factor NF-kappa-B p105 subunit | Transcription Factor | C00000956 | 0 / 0 |
| P16050 | Arachidonate 15-lipoxygenase | Enzyme | C00000956 | 0 / 0 |
| P04062 | Glucosylceramidase | Enzyme | C00000982 | 6 / 4 |
| P37059 | Estradiol 17-beta-dehydrogenase 2 | Enzyme | C00000982 | 0 / 0 |
| Q13093 | Platelet-activating factor acetylhydrolase | Enzyme | C00000956 | 3 / 0 |
| P49798 | Regulator of G-protein signaling 4 | Unclassified protein | C00003672 | 2 / 0 |
| Q6W5P4 | Neuropeptide S receptor | Neuropeptide receptor | C00000956 | 1 / 0 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00000956 | 0 / 0 |
| Q9HAW8 | UDP-glucuronosyltransferase 1-10 | Enzyme | C00000982 | 0 / 0 |
| O94956 | Solute carrier organic anion transporter family member 2B1 | Unclassified protein | C00000982 | 0 / 0 |
| P10275 | Androgen receptor | NR3C4 | C00000982 | 3 / 4 |
| Q07869 | Peroxisome proliferator-activated receptor alpha | NR1C1 | C00000982 | 0 / 0 |
| P07451 | Carbonic anhydrase 3 | Lyase | C00000956 | 0 / 0 |
| Q04760 | Lactoylglutathione lyase | Enzyme | C00000982 | 0 / 0 |
| P49888 | Estrogen sulfotransferase | Enzyme | C00000982 | 0 / 0 |
| P22748 | Carbonic anhydrase 4 | Lyase | C00000956 | 1 / 1 |
| P80365 | Corticosteroid 11-beta-dehydrogenase isozyme 2 | Enzyme | C00003672 | 1 / 1 |
| P10415 | Apoptosis regulator Bcl-2 | Other cytosolic protein | C00000956 | 0 / 7 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00000956 | 0 / 0 |
| Q9UIF8 | Bromodomain adjacent to zinc finger domain protein 2B | Unclassified protein | C00000956 | 0 / 0 |
| P46063 | ATP-dependent DNA helicase Q1 | Enzyme | C00000956 | 0 / 0 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00000956 | 0 / 0 |
| Q9Y6L6 | Solute carrier organic anion transporter family member 1B1 | Electrochemical transporter | C00000982 | 1 / 0 |
| P33527 | Multidrug resistance-associated protein 1 | drugs | C00000982 | 0 / 0 |
| P14061 | Estradiol 17-beta-dehydrogenase 1 | Enzyme | C00000982 | 0 / 0 |
| Q05513 | Protein kinase C zeta type | Iota | C00000956 | 0 / 0 |
| Q04759 | Protein kinase C theta type | Delta | C00000956 | 0 / 1 |
| Q02156 | Protein kinase C epsilon type | Eta | C00000956 | 0 / 0 |
| O94806 | Serine/threonine-protein kinase D3 | Pkd | C00000956 | 0 / 0 |
| P17252 | Protein kinase C alpha type | Alpha | C00000956 | 0 / 0 |
| Q05655 | Protein kinase C delta type | Delta | C00000956 | 0 / 0 |
| P05129 | Protein kinase C gamma type | Alpha | C00000956 | 1 / 1 |
| P05771 | Protein kinase C beta type | Alpha | C00000956 | 0 / 0 |
| P24723 | Protein kinase C eta type | Eta | C00000956 | 1 / 0 |
| P41743 | Protein kinase C iota type | Iota | C00000956 | 0 / 0 |
| Q15139 | Serine/threonine-protein kinase D1 | Pkd | C00000956 | 0 / 0 |
| Q9H0H5 | Rac GTPase-activating protein 1 | Unclassified protein | C00000956 | 0 / 0 |
35 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 4363 | ABCC1, ABC29, ABCC, GS-X, MRP, MRP1 | ATP-binding cassette, sub-family C (CFTR/MRP), member 1 |
C00000982
|
| 10257 | ABCC4, EST170205, MOAT-B, MOATB, MRP4 | ATP-binding cassette, sub-family C (CFTR/MRP), member 4 |
C00000982
|
| 10057 | ABCC5, ABC33, EST277145, MOAT-C, MOATC, MRP5, SMRP, pABC11 | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 |
C00000982
|
| 196 | AHR, bHLHe76 | aryl hydrocarbon receptor |
C00000982
|
| 1645 | AKR1C1, 2-ALPHA-HSD, 20-ALPHA-HSD, C9, DD1, DD1/DD2, DDH, DDH1, H-37, HAKRC, HBAB, MBAB | aldo-keto reductase family 1, member C1 (EC:1.3.1.20 1.1.1.149 1.1.1.112) |
C00000982
|
| 8644 | AKR1C3, DD3, DDX, HA1753, HAKRB, HAKRe, HSD17B5, PGFS, hluPGFS | aldo-keto reductase family 1, member C3 (EC:1.3.1.20 1.1.1.188 1.1.1.239 1.1.1.64 1.1.1.112 1.1.1.357) |
C00000982
|
| 207 | AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA | v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) |
C00000982
|
| 249 | ALPL, AP-TNAP, APTNAP, HOPS, TNAP, TNSALP | alkaline phosphatase, liver/bone/kidney (EC:3.1.3.1) |
C00000982
|
| 405 | ARNT, HIF-1-beta, HIF-1beta, HIF1-beta, HIF1B, HIF1BETA, TANGO, bHLHe2 | aryl hydrocarbon receptor nuclear translocator |
C00000982
|
| 596 | BCL2, Bcl-2, PPP1R50 | B-cell CLL/lymphoma 2 |
C00000982
|
| 836 | CASP3, CPP32, CPP32B, SCA-1 | caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) |
C00000982
|
| 842 | CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56 | caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) |
C00000982
|
| 1588 | CYP19A1, ARO, ARO1, CPV1, CYAR, CYP19, CYPXIX, P-450AROM | cytochrome P450, family 19, subfamily A, polypeptide 1 (EC:1.14.14.1) |
C00000982
|
| 1543 | CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX | cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) |
C00000982
|
| 1544 | CYP1A2, CP12, P3-450, P450(PA) | cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) |
C00000982
|
| 1545 | CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) |
C00000982
|
| 1559 | CYP2C9, CPC9, CYP2C, CYP2C10, CYPIIC9, P450IIC9 | cytochrome P450, family 2, subfamily C, polypeptide 9 (EC:1.14.13.48 1.14.13.49 1.14.13.80) |
C00000982
|
| 1576 | CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1 | cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) |
C00000982
|
| 2099 | ESR1, ER, ESR, ESRA, ESTRR, Era, NR3A1 | estrogen receptor 1 |
C00000982
|
| 2100 | ESR2, ER-BETA, ESR-BETA, ESRB, ESTRB, Erb, NR3A2 | estrogen receptor 2 (ER beta) |
C00000982
|
| 3576 | IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 | interleukin 8 |
C00000982
|
| 3757 | KCNH2, ERG1, HERG, HERG1, Kv11.1, LQT2, SQT1 | potassium voltage-gated channel, subfamily H (eag-related), member 2 |
C00000982
|
| 5444 | PON1, ESA, MVCD5, PON | paraoxonase 1 (EC:3.1.1.2 3.1.8.1 3.1.1.81) |
C00000982
|
| 6566 | SLC16A1, HHF7, MCT, MCT1 | solute carrier family 16 (monocarboxylate transporter), member 1 |
C00000982
|
| 6513 | SLC2A1, DYT17, DYT18, DYT9, EIG12, GLUT, GLUT1, GLUT1DS, HTLVR, PED | solute carrier family 2 (facilitated glucose transporter), member 1 |
C00000982
|
| 6817 | SULT1A1, HAST1/HAST2, P-PST, PST, ST1A1, ST1A3, STP, STP1, TSPST1 | sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 (EC:2.8.2.1) |
C00000982
|
| 6818 | SULT1A3, HAST, HAST3, M-PST, ST1A3/ST1A4, ST1A5, STM, TL-PST | sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3 (EC:2.8.2.1) |
C00000982
|
| 7124 | TNF, DIF, TNF-alpha, TNFA, TNFSF2 | tumor necrosis factor |
C00000982
|
| 7157 | TP53, BCC7, LFS1, P53, TRP53 | tumor protein p53 |
C00000982
|
| 54658 | UGT1A1, BILIQTL1, GNT1, HUG-BR1, UDPGT, UDPGT_1-1, UGT1, UGT1A | UDP glucuronosyltransferase 1 family, polypeptide A1 (EC:2.4.1.17) |
C00000982
|
| 54575 | UGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J | UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17) |
C00000982
|
| 54577 | UGT1A7, UDPGT, UDPGT_1-7, UGT-1G, UGT1-07, UGT1.7, UGT1G | UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17) |
C00000982
|
| 54576 | UGT1A8, UDPGT, UDPGT_1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H | UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17) |
C00000982
|
| 54600 | UGT1A9, HLUGP4, LUGP4, UDPGT, UDPGT_1-9, UGT-1I, UGT1-09, UGT1-9, UGT1.9, UGT1AI, UGT1I | UDP glucuronosyltransferase 1 family, polypeptide A9 (EC:2.4.1.17) |
C00000982
|
| 7366 | UGT2B15, HLUG4, UDPGT_2B8, UDPGT2B15, UDPGTH3, UGT2B8 | UDP glucuronosyltransferase 2 family, polypeptide B15 (EC:2.4.1.17) |
C00000982
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (95)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #103470 | Albinism, ocular, with sensorineural deafness |
P14679
|
| #203100 | Albinism, oculocutaneous, type ia; oca1a |
P14679
|
| #606952 | Albinism, oculocutaneous, type ib; oca1b |
P14679
|
| #300068 | Androgen insensitivity syndrome; ais |
P10275
|
| #312300 | Androgen insensitivity, partial; pais |
P10275
|
| #218030 | Apparent mineralocorticoid excess; ame |
P80365
|
| #613546 | Aromatase deficiency |
P11511
|
| #139300 | Aromatase excess syndrome; aexs |
P11511
|
| #600807 | Asthma, susceptibility to |
Q13093
|
| #608584 | Asthma-related traits, susceptibility to, 2 |
Q6W5P4
|
| #601816 | Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 |
P22309
|
| #614490 | Blood group, junior system; jr |
Q9UNQ0
|
| #210900 | Bloom syndrome; blm |
P54132
|
| %606641 | Body mass index; bmi |
P37231
|
| #609338 | Carotid intimal medial thickness 1 |
P37231
|
| #118300 | Charcot-marie-tooth disease and deafness |
Q01453
|
| #118220 | Charcot-marie-tooth disease, demyelinating, type 1a; cmt1a |
Q01453
|
| #114500 | Colorectal cancer; crc |
P18054
P84022 |
| #218800 | Crigler-najjar syndrome, type i |
P22309
P22310 |
| #606785 | Crigler-najjar syndrome, type ii |
P22309
P22310 |
| #119900 | Digital clubbing, isolated congenital |
P15428
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #237500 | Dubin-johnson syndrome; djs |
Q92887
|
| #133239 | Esophageal cancer |
P18054
|
| #615363 | Estrogen resistance; estrr |
P03372
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #608013 | Gaucher disease, perinatal lethal |
P04062
|
| #230800 | Gaucher disease, type i |
P04062
|
| #230900 | Gaucher disease, type ii |
P04062
|
| #231000 | Gaucher disease, type iii |
P04062
|
| #231005 | Gaucher disease, type iiic |
P04062
|
| #143500 | Gilbert syndrome |
P22309
P22310 |
| #137750 | Glaucoma 1, open angle, a; glc1a |
Q16678
|
| #231300 | Glaucoma 3, primary congenital, a; glc3a |
Q16678
|
| #137760 | Glaucoma, primary open angle; poag |
Q16678
|
| #137800 | Glioma susceptibility 1; glm1 |
P37231
|
| #232300 | Glycogen storage disease ii |
P10253
|
| #139393 | Guillain-barre syndrome, familial; gbs |
Q01453
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #114550 | Hepatocellular carcinoma |
P08581
|
| #237450 | Hyperbilirubinemia, rotor type; hblrr |
Q9NPD5
Q9Y6L6 |
| #237900 | Hyperbilirubinemia, transient familial neonatal; hblrtfn |
P22309
|
| #143860 | Hyperchlorhidrosis, isolated |
O43570
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #145900 | Hypertrophic neuropathy of dejerine-sottas |
Q01453
|
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 |
P15428
|
| #146300 | Hypophosphatasia, adult |
P05186
|
| #241510 | Hypophosphatasia, childhood |
P05186
|
| #241500 | Hypophosphatasia, infantile |
P05186
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #147050 | Ige responsiveness, atopic; iger |
Q13093
|
| #612244 | Inflammatory bowel disease 13; ibd13 |
P08183
|
| #601626 | Leukemia, acute myeloid; aml |
P36888
|
| #604367 | Lipodystrophy, familial partial, type 3; fpld3 |
P37231
|
| #613795 | Loeys-dietz syndrome, type 3; lds3 |
P84022
|
| #613839 | Megaloblastic anemia due to dihydrofolate reductase deficiency |
P00374
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
| #162500 | Neuropathy, hereditary, with liability to pressure palsies; hnpp |
Q01453
|
| #601665 | Obesity |
P37231
|
| #259730 | Osteopetrosis, autosomal recessive 3; optb3 |
P00918
|
| #168600 | Parkinson disease, late-onset; pd |
P04062
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #604229 | Peters anomaly |
Q16678
|
| #172700 | Pick disease of brain |
P10636
|
| #614278 | Platelet-activating factor acetylhydrolase deficiency; pafad |
Q13093
|
| #614390 | Pregnancy loss, recurrent, susceptibility to, 2; rprgl2 |
P00734
|
| #613679 | Prothrombin deficiency, congenital |
P00734
|
| #605074 | Renal cell carcinoma, papillary, 1; rccp1 |
P08581
|
| #600852 | Retinitis pigmentosa 17; rp17 |
P22748
|
| #604906 | Schizophrenia 9; sczd9 |
P49798
|
| #181500 | Schizophrenia; sczd |
P49798
|
| #601800 | Skin/hair/eye pigmentation, variation in, 3; shep3 |
P14679
|
| #313200 | Spinal and bulbar muscular atrophy, x-linked 1; smax1 |
P10275
|
| #253300 | Spinal muscular atrophy, type i; sma1 |
Q16637
|
| #253550 | Spinal muscular atrophy, type ii; sma2 |
Q16637
|
| #253400 | Spinal muscular atrophy, type iii; sma3 |
Q16637
|
| #271150 | Spinal muscular atrophy, type iv; sma4 |
Q16637
|
| #605361 | Spinocerebellar ataxia 14; sca14 |
P05129
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
| #601367 | Stroke, ischemic |
P00734
P24723 |
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #188050 | Thrombophilia due to thrombin defect; thph1 |
P00734
|
| #138900 | Uric acid concentration, serum, quantitative trait locus 1; uaqtl1 |
Q9UNQ0
|
| #614916 | Ventricular tachycardia, catecholaminergic polymorphic, 4; cpvt4 |
P62158
|
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
| #278300 | Xanthinuria, type i |
P47989
|
| #278750 | Xeroderma pigmentosum, variant type; xpv |
Q9Y253
|
| #112100 | Yt blood group antigen |
P22303
|
KEGG DISEASE (77)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
|
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H01302 | Hyperchlorhidrosis isolated (HCHLH) |
O43570
(related)
|
| H00021 | Renal cell carcinoma |
O43570
(marker)
P08581 (related) Q16790 (marker) |
| H01197 | Dihydrofolate reductase (DHFR) deficiency |
P00374
(related)
|
| H00223 | Inherited thrombophilia |
P00734
(related)
|
| H01254 | Congenital prothrombin deficiency |
P00734
(related)
|
| H00241 | Combined proximal and distal renal tubular acidosis (RTA type 3) |
P00918
(related)
|
| H00436 | Osteopetrosis |
P00918
(related)
|
| H00026 | Endometrial Cancer |
P03372
(marker)
Q92731 (marker) |
| H00066 | Lewy body dementia (LBD) |
P04062
(related)
|
| H00126 | Gaucher disease |
P04062
(related)
|
| H00426 | Defects in the degradation of ganglioside |
P04062
(related)
|
| H00810 | Progressive myoclonic epilepsy (PME) |
P04062
(related)
|
| H00599 | 46,XX disorders of sex development (Disorders related to androgen excess) |
P04150
(related)
P11511 (related) |
| H00063 | Spinocerebellar ataxia (SCA) |
P05129
(related)
Q9NUW8 (related) |
| H00213 | Hypophosphatasia |
P05186
(related)
|
| H00018 | Gastric cancer |
P08581
(related)
P10415 (related) P24864 (related) |
| H00046 | Cholangiocarcinoma |
P08581
(related)
P35354 (related) |
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H00069 | Glycogen storage diseases (GSD) |
P10253
(related)
|
| H00024 | Prostate cancer |
P10275
(related)
|
| H00062 | Spinal and bulbar muscular atrophy (SBMA) |
P10275
(related)
|
| H00608 | 46,XY disorders of sex development (Disorders in androgen synthesis or action) |
P10275
(related)
|
| H00609 | 46,XY disorders of sex development (Other) |
P10275
(related)
|
| H00005 | Chronic lymphocytic leukemia (CLL) |
P10415
(related)
P28907 (marker) |
| H00013 | Small cell lung cancer |
P10415
(related)
|
| H00028 | Choriocarcinoma |
P10415
(related)
|
| H00030 | Cervical cancer |
P10415
(related)
|
| H00041 | Kaposi's sarcoma |
P10415
(related)
|
| H00054 | Nasopharyngeal cancer |
P10415
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00023 | Testicular cancer |
P10696
(marker)
|
| H00342 | Tuberculosis |
P11473
(related)
|
| H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
| H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
| H00794 | Aromatase excess syndrome |
P11511
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00168 | Oculocutaneous albinism (OCA) |
P14679
(related)
|
| H00038 | Malignant melanoma |
P14679
(marker)
|
| H00457 | Primary hypertrophic osteoarthropathy (PHO) |
P15428
(related)
|
| H01246 | Isolated congenital nail clubbing (ICNC) |
P15428
(related)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P16473
(related)
|
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H00208 | Hyperbilirubinemia |
P22309
(related)
Q92887 (related) |
| H00527 | Retinitis pigmentosa (RP) |
P22748
(related)
|
| H00055 | Laryngeal cancer |
P24864
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00017 | Esophageal cancer |
P35354
(related)
|
| H00025 | Penile cancer |
P35354
(related)
|
| H00003 | Acute myeloid leukemia (AML) |
P36888
(related)
|
| H00032 | Thyroid cancer |
P37231
(related)
|
| H00409 | Type II diabetes mellitus |
P37231
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P37231
(related)
|
| H00192 | Xanthinuria |
P47989
(related)
|
| H00094 | DNA repair defects |
P54132
(related)
|
| H00296 | Defects in RecQ helicases |
P54132
(related)
|
| H00259 | Apparent mineralocorticoid excess syndrome |
P80365
(related)
|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
Q01453
(related)
|
| H01296 | Hereditary neuropathy with liability to pressure palsies (HNPP) |
Q01453
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q03164
(related)
Q03164 (marker) |
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00408 | Type I diabetes mellitus |
Q04759
(related)
|
| H00455 | Spinal muscular atrophy (SMA) |
Q16637
(related)
|
| H00612 | Primary open angle glaucoma |
Q16678
(related)
|
| H01075 | Peters anomaly |
Q16678
(related)
|
| H01159 | Anterior segment dysgenesis (ASD) |
Q16678
(related)
|
| H01203 | Primary congenital glaucoma (PCG) |
Q16678
(related)
|
| H00480 | Non-syndromic X-linked mental retardation |
Q99714
(related)
|
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|
| H00403 | Disorders of nucleotide excision repair |
Q9Y253
(related)
|
Diseases related to CTD interactions
10 disease in interactions with metabolites
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D000647 | Amnesia |
C00000982
|
| D001932 | Brain Neoplasms |
C00000982
|
| D009202 | Cardiomyopathies |
C00000982
|
| D056486 | Drug-Induced Liver Injury |
C00000982
|
| D064420 | Drug-Related Side Effects and Adverse Reactions |
C00000982
|
| D007674 | Kidney Diseases |
C00000982
|
| D008106 | Liver Cirrhosis, Experimental |
C00000982
|
| D008107 | Liver Diseases |
C00000982
|
| D009369 | Neoplasms |
C00000982
|
| D009374 | Neoplasms, Experimental |
C00000982
|