KCF-S cluster No. 589 (14 metabolites)

Corresponding Phytochemical cluster No. 15

• Index
• Plant Species
• KEGG BRITE br08003
• Metabolite list (14)
• Human Protein
  / Gene in interactions
• Related Diseases

Plant Species

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Cumulative plant class count

class name	count
rosids	63
asterids	2

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Cumulative family count

class name	count
Fabaceae	63
Convolvulaceae	2

KEGG BRITE br08003

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Categories (1)

br08003 Category	# of metabolite
Rotenones	4

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metabolites link (5)

br08003 Category	KEGG ID	KNApSAcK ID
Rotenones	C10417	C00002522
Rotenones	C10506	C00002550
Rotenones	C10535	C00002578
Rotenones	C10537	C00002580
Rotenones	C10537	C00029676

Metabolite list (14)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	figure
C00002522	Deguelin / (-)-cis-Deguelin	CHEMBL393417 CHEMBL1592086	C107676	12 / 20 / 45	86 / 10
C00002550	Millettone		C480849
C00002578	Tephrosin	CHEMBL241806	C480848		6 / 0
C00002580	Toxicarol / Toxicarin / alpha-Toxicarol	CHEMBL508992 CHEMBL1488225		10 / 9 / 6
C00009587	Millettosin / 12a-Hydroxymillettone
C00009591	11-Hydroxytephrosin	CHEMBL419669
C00009978	Erythynone / (+)-2,3,10-Trimethoxy-6'',6''-dimethylpyrano[2'',3'':9,8]rotenone
C00009985	(+)-12a-Hydroxyerythynone
C00018961	Erypoegin G / 5-Hydroxy-7,2'-dimethoxy-6'',6''-dimethylpyrano[2'',3'':4',5']isoflavanone
C00018978	(R)-Saclenone / (R)-5-Hydroxy-2',4',5'-trimethoxy-2'',2''-dimethylpyrano[5'',6'':6,7]isoflavanone
C00019050	(+)-12a-Epimillettosin / (6aS,12aS)-12a-Hydroxy-2,3-methylenedioxy-6',6'-dimethoxypyr[2',3':9,8]rotenone
C00019586	(-)-13alpha-Hydroxydeguelin
C00019587	(-)-13alpha-Hydroxytephrosin
C00029676	alpha-Toxicarol / (-)-alpha-Toxicarol	CHEMBL508992 CHEMBL1488225		10 / 9 / 6

Human Protein / Gene in interactions

18 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
O94782	Ubiquitin carboxyl-terminal hydrolase 1	Enzyme	C00002522 C00002580 C00029676	0 / 0
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00002522 C00002580 C00029676	0 / 1
Q16637	Survival motor neuron protein	Unclassified protein	C00002522 C00002580 C00029676	4 / 1
P10636	Microtubule-associated protein tau	Unclassified protein	C00002522 C00002580 C00029676	4 / 3
O75604	Ubiquitin carboxyl-terminal hydrolase 2	Enzyme	C00002580 C00029676	0 / 0
B2RXH2	Lysine-specific demethylase 4E	Enzyme	C00002580 C00029676	0 / 0
P00352	Retinal dehydrogenase 1	Enzyme	C00002580 C00029676	0 / 0
Q96QE3	ATPase family AAA domain-containing protein 5	Unclassified protein	C00002580 C00029676	0 / 0
Q9NUW8	Tyrosyl-DNA phosphodiesterase 1	Enzyme	C00002580 C00029676	1 / 1
P28482	Mitogen-activated protein kinase 1	Erk	C00002580 C00029676	0 / 0
P05177	Cytochrome P450 1A2	Cytochrome P450 1A2	C00002522	0 / 0
Q9HC16	DNA dC->dU-editing enzyme APOBEC-3G	Enzyme	C00002522	0 / 0
P33261	Cytochrome P450 2C19	Cytochrome P450 2C19	C00002522	1 / 1
P11712	Cytochrome P450 2C9	Cytochrome P450 2C9	C00002522	0 / 1
P27695	DNA-(apurinic or apyrimidinic site) lyase	Enzyme	C00002522	0 / 0
P16473	Thyrotropin receptor	Glycohormone receptor	C00002522	3 / 2
P04637	Cellular tumor antigen p53	Transcription Factor	C00002522	7 / 37
P10635	Cytochrome P450 2D6	Cytochrome P450 2D6	C00002522	1 / 0

89 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
4318	MMP9, CLG4B, GELB, MANDP2, MMP-9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35)	C00002522 C00002578
7124	TNF, DIF, TNF-alpha, TNFA, TNFSF2	tumor necrosis factor	C00002522 C00002578
5743	PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1)	C00002522 C00002578
6615	SNAI1, SLUGH2, SNA, SNAH, SNAIL, SNAIL1, dJ710H13.1	snail family zinc finger 1	C00002522
545	ATR, FCTCS, FRP1, MEC1, SCKL, SCKL1	ataxia telangiectasia and Rad3 related (EC:2.7.11.1)	C00002522
596	BCL2, Bcl-2, PPP1R50	B-cell CLL/lymphoma 2	C00002522
598	BCL2L1, BCL-XL/S, BCL2L, BCLX, BCLXL, BCLXS, Bcl-X, PPP1R52, bcl-xL, bcl-xS	BCL2-like 1	C00002522
332	BIRC5, API4, EPR-1	baculoviral IAP repeat containing 5	C00002522
672	BRCA1, BRCAI, BRCC1, BROVCA1, IRIS, PNCA4, PPP1R53, PSCP, RNF53	breast cancer 1, early onset	C00002522
768	CA9, CAIX, MN	carbonic anhydrase IX (EC:4.2.1.1)	C00002522
836	CASP3, CPP32, CPP32B, SCA-1	caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56)	C00002522
840	CASP7, CASP-7, CMH-1, ICE-LAP3, LICE2, MCH3	caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60)	C00002522
595	CCND1, BCL1, D11S287E, PRAD1, U21B31	cyclin D1	C00002522
1001	CDH3, CDHP, HJMD, PCAD	cadherin 3, type 1, P-cadherin (placental)	C00002522
1005	CDH7, CDH7L1	cadherin 7, type 2	C00002522
1007	CDH9	cadherin 9, type 2 (T1-cadherin)	C00002522
1019	CDK4, CMM3, PSK-J3	cyclin-dependent kinase 4 (EC:2.7.11.22)	C00002522
1026	CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	C00002522
8837	CFLAR, CASH, CASP8AP1, CLARP, Casper, FLAME, FLAME-1, FLAME1, FLIP, I-FLICE, MRIT, c-FLIP, c-FLIPL, c-FLIPR, c-FLIPS	CASP8 and FADD-like apoptosis regulator	C00002522
9075	CLDN2	claudin 2	C00002522
7122	CLDN5, AWAL, BEC1, CPETRL1, TMVCF	claudin 5	C00002522
1499	CTNNB1, CTNNB, MRD19, armadillo	catenin (cadherin-associated protein), beta 1, 88kDa	C00002522
7852	CXCR4, CD184, D2S201E, FB22, HM89, HSY3RR, LAP3, LCR1, LESTR, NPY3R, NPYR, NPYRL, NPYY3R, WHIM	chemokine (C-X-C motif) receptor 4	C00002522
27123	DKK2, DKK-2	dickkopf WNT signaling pathway inhibitor 2	C00002522
27121	DKK4, DKK-4	dickkopf WNT signaling pathway inhibitor 4	C00002522
1956	EGFR, ERBB, ERBB1, HER1, PIG61, mENA	epidermal growth factor receptor (EC:2.7.10.1)	C00002522
112399	EGLN3, HIFP4H3, HIFPH3, PHD3	egl-9 family hypoxia-inducible factor 3 (EC:1.14.11.29)	C00002522
1978	EIF4EBP1, 4E-BP1, 4EBP1, BP-1, PHAS-I	eukaryotic translation initiation factor 4E binding protein 1	C00002522
2034	EPAS1, ECYT4, HIF2A, HLF, MOP2, PASD2, bHLHe73	endothelial PAS domain protein 1	C00002522
2487	FRZB, FRE, FRITZ, FRP-3, FRZB-1, FRZB-PEN, FRZB1, FZRB, OS1, SFRP3, SRFP3, hFIZ	frizzled-related protein	C00002522
11211	FZD10, CD350, FZ-10, Fz10, FzE7, hFz10	frizzled family receptor 10	C00002522
8322	FZD4, CD344, EVR1, FEVR, FZD4S, Fz-4, Fz4, FzE4, GPCR, hFz4	frizzled family receptor 4	C00002522
8325	FZD8, FZ-8, hFZ8	frizzled family receptor 8	C00002522
2932	GSK3B	glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26)	C00002522
3091	HIF1A, HIF-1A, HIF-1alpha, HIF1, HIF1-ALPHA, MOP1, PASD8, bHLHe78	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	C00002522
3383	ICAM1, BB2, CD54, P3.58	intercellular adhesion molecule 1	C00002522
3479	IGF1, IGF-I, IGF1A, IGFI	insulin-like growth factor 1 (somatomedin C)	C00002522
3480	IGF1R, CD221, IGFIR, IGFR, JTK13	insulin-like growth factor 1 receptor (EC:2.7.10.1)	C00002522
3549	IHH, BDA1, HHG2	indian hedgehog	C00002522
3586	IL10, CSIF, GVHDS, IL-10, IL10A, TGIF	interleukin 10	C00002522
3576	IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1	interleukin 8	C00002522
3791	KDR, CD309, FLK1, VEGFR, VEGFR2	kinase insert domain receptor (a type III receptor tyrosine kinase) (EC:2.7.10.1)	C00002522
4015	LOX	lysyl oxidase (EC:1.4.3.13)	C00002522
5604	MAP2K1, CFC3, MAPKK1, MEK1, MKK1, PRKMK1	mitogen-activated protein kinase kinase 1 (EC:2.7.12.2)	C00002522
5605	MAP2K2, CFC4, MAPKK2, MEK2, MKK2, PRKMK2	mitogen-activated protein kinase kinase 2 (EC:2.7.12.2)	C00002522
4170	MCL1, BCL2L3, EAT, MCL1-ES, MCL1L, MCL1S, Mcl-1, TM, bcl2-L-3, mcl1/EAT	myeloid cell leukemia sequence 1 (BCL2-related)	C00002522
4255	MGMT	O-6-methylguanine-DNA methyltransferase (EC:2.1.1.63)	C00002522
4288	MKI67, KIA, MIB-1	marker of proliferation Ki-67	C00002522
133	ADM, AM	adrenomedullin	C00002522
2475	MTOR, FRAP, FRAP1, FRAP2, RAFT1, RAPT1	mechanistic target of rapamycin (serine/threonine kinase) (EC:2.7.11.1)	C00002522
4609	MYC, MRTL, MYCC, bHLHe39, c-Myc	v-myc avian myelocytomatosis viral oncogene homolog	C00002522
8202	NCOA3, ACTR, AIB-1, AIB1, CAGH16, CTG26, KAT13B, RAC3, SRC-3, SRC3, TNRC14, TNRC16, TRAM-1, bHLHe42, pCIP	nuclear receptor coactivator 3 (EC:2.3.1.48)	C00002522
4792	NFKBIA, IKBA, MAD-3, NFKBI	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	C00002522
4846	NOS3, ECNOS, eNOS	nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39)	C00002522
4928	NUP98, ADIR2, NUP196, NUP96	nucleoporin 98kDa	C00002522
4953	ODC1, ODC	ornithine decarboxylase 1 (EC:4.1.1.17)	C00002522
142	PARP1, ADPRT, ADPRT_1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1	poly (ADP-ribose) polymerase 1 (EC:2.4.2.30)	C00002522
5163	PDK1	pyruvate dehydrogenase kinase, isozyme 1 (EC:2.7.11.2)	C00002522
5290	PIK3CA, CLOVE, CWS5, MCAP, MCM, MCMTC, PI3K, p110-alpha	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha (EC:2.7.11.1 2.7.1.153)	C00002522
5591	PRKDC, DNA-PKcs, DNAPK, DNPK1, HYRC, HYRC1, XRCC7, p350	protein kinase, DNA-activated, catalytic polypeptide (EC:2.7.11.1)	C00002522
51129	ANGPTL4, ANGPTL2, ARP4, FIAF, HARP, HFARP, NL2, PGAR, UNQ171, pp1158	angiopoietin-like 4	C00002522
5925	RB1, OSRC, RB, p105-Rb, pRb, pp110	retinoblastoma 1	C00002522
5970	RELA, NFKB3, p65	v-rel avian reticuloendotheliosis viral oncogene homolog A	C00002522
6194	RPS6, S6	ribosomal protein S6	C00002522
6198	RPS6KB1, PS6K, S6K, S6K-beta-1, S6K1, STK14A, p70_S6KA, p70(S6K)-alpha, p70-S6K, p70-alpha	ribosomal protein S6 kinase, 70kDa, polypeptide 1 (EC:2.7.11.1)	C00002522
6423	SFRP2, FRP-2, SARP1, SDF-5	secreted frizzled-related protein 2	C00002522
472	ATM, AT1, ATA, ATC, ATD, ATDC, ATE, TEL1, TELO1	ataxia telangiectasia mutated (EC:2.7.11.1)	C00002522
8403	SOX14, SOX28	SRY (sex determining region Y)-box 14	C00002522
11063	SOX30	SRY (sex determining region Y)-box 30	C00002522
6660	SOX5, L-SOX5	SRY (sex determining region Y)-box 5	C00002522
6714	SRC, ASV, SRC1, c-SRC, p60-Src	v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (EC:2.7.10.2)	C00002522
6774	STAT3, APRF, HIES	signal transducer and activator of transcription 3 (acute-phase response factor)	C00002522
6778	STAT6, D12S1644, IL-4-STAT, STAT6B, STAT6C	signal transducer and activator of transcription 6, interleukin-4 induced	C00002522
412	STS, ARSC, ARSC1, ASC, ES, SSDD, XLI	steroid sulfatase (microsomal), isozyme S (EC:3.1.6.2)	C00002522
6925	TCF4, E2-2, ITF-2, ITF2, PTHS, SEF-2, SEF2, SEF2-1, SEF2-1A, SEF2-1B, TCF-4, bHLHb19	transcription factor 4	C00002522
207	AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA	v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1)	C00002522
7157	TP53, BCC7, LFS1, P53, TRP53	tumor protein p53	C00002522
7422	VEGFA, MVCD1, VEGF, VPF	vascular endothelial growth factor A	C00002522
11197	WIF1, WIF-1	WNT inhibitory factor 1	C00002522
80326	WNT10A, OODD, SSPS, STHAG4	wingless-type MMTV integration site family, member 10A	C00002522
7481	WNT11, HWNT11	wingless-type MMTV integration site family, member 11	C00002522
7222233			C00002522
7472	WNT2, INT1L1, IRP	wingless-type MMTV integration site family member 2	C00002522
7482	WNT2B, WNT13, XWNT2	wingless-type MMTV integration site family, member 2B	C00002522
89780	WNT3A	wingless-type MMTV integration site family, member 3A	C00002522
331	XIAP, API3, BIRC4, IAP-3, ILP1, MIHA, XLP2, hIAP-3, hIAP3	X-linked inhibitor of apoptosis	C00002522
329	BIRC2, API1, HIAP2, Hiap-2, MIHB, RNF48, c-IAP1, cIAP1	baculoviral IAP repeat containing 2	C00002578
330	BIRC3, AIP1, API2, CIAP2, HAIP1, HIAP1, MALT2, MIHC, RNF49, c-IAP2	baculoviral IAP repeat containing 3	C00002578
4843	NOS2, HEP-NOS, INOS, NOS, NOS2A	nitric oxide synthase 2, inducible (EC:1.14.13.39)	C00002578

Related Diseases

Diseases related to proteins in ChEMBL interactions

Diseases related to CTD interactions