PCIDB

KNApSAcK Metabolite C00002578

Metabolite

KNApSAcK Entry

id C00002578
Name Tephrosin
CAS RN 76-80-2
Standard InChI InChI=1S/C23H22O7/c1-22(2)8-7-12-15(30-22)6-5-13-20(12)29-19-11-28-16-10-18(27-4)17(26-3)9-14(16)23(19,25)21(13)24/h5-10,19,25H,11H2,1-4H3/t19-,23-/m1/s1
Standard InChI (Main Layer) InChI=1S/C23H22O7/c1-22(2)8-7-12-15(30-22)6-5-13-20(12)29-19-11-28-16-10-18(27-4)17(26-3)9-14(16)23(19,25)21(13)24/h5-10,19,25H,11H2,1-4H3

Cluster

Phytochemical cluster No. 15
KCF-S cluster No. 589

Link

ChEMBL

By standard InChI CHEMBL241806
By standard InChI Main Layer CHEMBL241806

KEGG

By LinkDB C10535

CTD

By CAS RN C480848

Human Protein / Gene in interaction

CTD interaction (10)

compound gene gene name gene description interaction interaction type form reference
pmid
C480848 329 BIRC2
API1
HIAP2
Hiap-2
MIHB
RNF48
c-IAP1
cIAP1
baculoviral IAP repeat containing 2 tephrosin inhibits the reaction [TNF protein results in increased expression of BIRC2 protein] decreases reaction
/ increases expression
protein 18841906
C480848 330 BIRC3
AIP1
API2
CIAP2
HAIP1
HIAP1
MALT2
MIHC
RNF49
c-IAP2
baculoviral IAP repeat containing 3 tephrosin inhibits the reaction [TNF protein results in increased expression of BIRC3 protein] decreases reaction
/ increases expression
protein 18841906
C480848 4318 MMP9
CLG4B
GELB
MANDP2
MMP-9
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) tephrosin inhibits the reaction [TNF protein results in increased expression of MMP9 protein] decreases reaction
/ increases expression
protein 18841906
C480848 4843 NOS2
HEP-NOS
INOS
NOS
NOS2A
nitric oxide synthase 2, inducible (EC:1.14.13.39) tephrosin inhibits the reaction [TNF protein results in increased expression of NOS2 protein] decreases reaction
/ increases expression
protein 18841906
C480848 5743 PTGS2
COX-2
COX2
GRIPGHS
PGG/HS
PGHS-2
PHS-2
hCox-2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) tephrosin inhibits the reaction [TNF protein results in increased expression of PTGS2 protein] decreases reaction
/ increases expression
protein 18841906
C480848 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor tephrosin inhibits the reaction [TNF protein results in increased expression of BIRC2 protein] decreases reaction
/ increases expression
protein 18841906
C480848 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor tephrosin inhibits the reaction [TNF protein results in increased expression of BIRC3 protein] decreases reaction
/ increases expression
protein 18841906
C480848 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor tephrosin inhibits the reaction [TNF protein results in increased expression of MMP9 protein] decreases reaction
/ increases expression
protein 18841906
C480848 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor tephrosin inhibits the reaction [TNF protein results in increased expression of NOS2 protein] decreases reaction
/ increases expression
protein 18841906
C480848 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor tephrosin inhibits the reaction [TNF protein results in increased expression of PTGS2 protein] decreases reaction
/ increases expression
protein 18841906