Amorpha fruticosa

• Index
• Plant Species
• Metabolite list (40)
• Human Protein
  / Gene in interactions
• Related Diseases

Species

KNApSAcK Entry

Organism name	Amorpha fruticosa
Genus	Amorpha
Family	Fabaceae
Kingdom	Plantae

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NCBI taxonomy

Entry

Linked NCBI taxonomy name	Amorpha fruticosa
Linked NCBI taxonomy ID	48131
Linked level	species

Family

Family in NCBI taxonomy	Fabaceae
ID	3803

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy	Viridiplantae
ID	33090

Plant class

Plant class	rosids
ID	71275

Metabolite list (40)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	KCF-S cluster	phytochemical cluster	figure
C00004139	Salipurpin / Apigenin 5-glucoside / Apigenin 5-O-beta-D-glucopyranoside					No. 2	No. 15
C00002525	Formononetin / 7-Hydroxy-4'-methoxyisoflavone	CHEMBL242341	C007768	24 / 36 / 58	13 / 0	No. 3	No. 15
C00009417	7,2',4',5'-Tetramethoxyisoflavone	CHEMBL478578	C091093			No. 8	No. 15
C00008321	Amoradicin					No. 19	No. 14
C00008176	5,7-Dihydroxy-8-C-geranylflavanone					No. 19	No. 14
C00008322	Amoradinin					No. 19	No. 14
C00009601	Dehydrodeguelin / 6a,12a-Dehydrodeguelin	CHEMBL465673				No. 24	No. 15
C00009605	Dehydrotoxicarol / 7a,13a-Didehydrotoxicarol	CHEMBL122787				No. 24	No. 15
C00009986	6-Hydroxy-6a,12a-dehydro-alpha-toxicarol					No. 24	No. 15
C00009413	7-Hydroxy-2',4',5'-trimethoxyisoflavone	CHEMBL455048				No. 35	No. 15
C00008325	Amorinin					No. 39
C00008473	Amorin					No. 39
C00008475	Amoridin					No. 39
C00008476	Amoricin					No. 39
C00044194	Isoamorin					No. 39
C00008324	Amoritin					No. 170	No. 14
C00014178	Isoamoritin / 5,7,3'-Trihydroxy-4'-methoxy-6,8,5'-triprenylflavanone					No. 170	No. 14
C00008269	Amorilin	CHEMBL561642				No. 170	No. 14
C00008323	Amorisin	CHEMBL551156				No. 170	No. 14
C00009604	Dehydroamorphigenin / 6a,12a-Didehydroamorphigenin	CHEMBL1456805 CHEMBL1613441		4 / 7 / 11		No. 236	No. 15
C00009974	3-O-Demethylamorphigenin					No. 281	No. 15
C00009590	Dalbinol	CHEMBL465761				No. 281	No. 15
C00044049	12a-Hydroxyamorphigenin	CHEMBL515078	C044989			No. 281	No. 15
C00009576	Dihydroamorphigenin / 22,23-Dihydro-24-hydroxyrotenone					No. 281	No. 15
C00009575	Amorphigenin / 8'-Hydroxyrotenone	CHEMBL465552 CHEMBL1447847 CHEMBL1490209	C049148	7 / 8 / 12	1 / 0	No. 281	No. 15
C00009577	Dalpanol / 6',7'-Dihydro-6'-hydroxyrotenone	CHEMBL518129 CHEMBL1700300		3 / 3 / 1		No. 281	No. 15
C00002537	Rotenolone / 12a-Hydroxyrotenone	CHEMBL240545				No. 281	No. 15
C00009579	Amorphigenol					No. 281	No. 15
C00020130	gamma-Muurolene / 1beta-Cadina-4,10(15)-diene					No. 283	No. 39
C00011617	AR-Curcumene / (R)-(-)-alpha-Curcumene	CHEMBL469717				No. 456	No. 38
C00009744	Amorphaquinone / 7-Hydroxy-8,3',4'-trimethoxyisoflavanquinone					No. 517
C00009591	11-Hydroxytephrosin	CHEMBL419669				No. 589	No. 15
C00002578	Tephrosin	CHEMBL241806	C480848		6 / 0	No. 589	No. 15
C00009574	Rotenonic acid	CHEMBL2181295				No. 765
C00010180	Amorphol / Amorphigenol O-vicianoside					No. 813
C00010181	Dalbin / Dalbinol O-glucoside					No. 813
C00015333	Amorphastilbol / 3,5-Dihydroxy-4-geranylstilbene	CHEMBL500257		3 / 5 / 3		No. 1111	No. 13
C00015437	Amorfrutin A / 3-Hydroxy-4-isopentenyl-5-methoxybibenzyl-2-carboxylic acid	CHEMBL491820		9 / 14 / 6		No. 1953
C00015520	Amorfrutin B / 3-Hydroxy-5-methoxy-4-geranylbibenzyl-2-carboxylic acid					No. 1953
C00013562	Amorphispironone / (1R,7'aR,10'aS)-10',10'a-Dihydro-4,5-dimethoxy-3',3'-dimethylspiro[3,5-cyclohexadiene-1,8'-[3H,8H]furo[3,4-e']benzo[1,2-b:3,4-b']dipyran]-2,7'(7'aH)-dione	CHEMBL491001 CHEMBL1712104 CHEMBL1985734		6 / 8 / 4		No. 7246

Human Protein / Gene in interactions

35 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
Q16236	Nuclear factor erythroid 2-related factor 2	Unclassified protein	C00002525 C00009577 C00013562 C00015437	0 / 0
Q07869	Peroxisome proliferator-activated receptor alpha	NR1C1	C00002525 C00015333 C00015437	0 / 0
O00255	Menin	Unclassified protein	C00002525 C00009575 C00009604	2 / 5
P37231	Peroxisome proliferator-activated receptor gamma	NR1C3	C00002525 C00015333 C00015437	5 / 3
Q03164	Histone-lysine N-methyltransferase 2A	Enzyme	C00002525 C00009575 C00009604	1 / 2
P10636	Microtubule-associated protein tau	Unclassified protein	C00002525 C00009575 C00009604	4 / 3
Q03181	Peroxisome proliferator-activated receptor delta	NR1C2	C00002525 C00015333 C00015437	0 / 0
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00002525 C00009575	0 / 1
P33261	Cytochrome P450 2C19	Cytochrome P450 2C19	C00002525 C00009575	1 / 1
P63092	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	Other membrane protein	C00013562 C00015437	7 / 3
P11712	Cytochrome P450 2C9	Cytochrome P450 2C9	C00002525 C00009604	0 / 1
P00352	Retinal dehydrogenase 1	Enzyme	C00002525 C00009575	0 / 0
P84022	Mothers against decapentaplegic homolog 3	Unclassified protein	C00009577 C00015437	2 / 0
P10635	Cytochrome P450 2D6	Cytochrome P450 2D6	C00002525	1 / 0
O75496	Geminin	Unclassified protein	C00015437	0 / 0
P38398	Breast cancer type 1 susceptibility protein	Enzyme	C00002525	4 / 2
P43220	Glucagon-like peptide 1 receptor	Glucagon-like peptide receptor	C00015437	0 / 0
P39748	Flap endonuclease 1	Enzyme	C00015437	0 / 0
P11021	78 kDa glucose-regulated protein	Unclassified protein	C00002525	0 / 0
P04798	Cytochrome P450 1A1	Cytochrome P450 1A1	C00002525	0 / 0
P28482	Mitogen-activated protein kinase 1	Erk	C00009575	0 / 0
Q99714	3-hydroxyacyl-CoA dehydrogenase type-2	Enzyme	C00002525	3 / 3
P15428	15-hydroxyprostaglandin dehydrogenase [NAD(+)]	Enzyme	C00002525	2 / 2
Q96QE3	ATPase family AAA domain-containing protein 5	Unclassified protein	C00013562	0 / 0
Q13526	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	Enzyme	C00013562	0 / 0
Q99700	Ataxin-2	Unclassified protein	C00013562	1 / 1
Q9UNA4	DNA polymerase iota	Enzyme	C00013562	0 / 0
Q16637	Survival motor neuron protein	Unclassified protein	C00002525	4 / 1
P31639	Sodium/glucose cotransporter 2	Glucose	C00002525	1 / 1
P04637	Cellular tumor antigen p53	Transcription Factor	C00002525	7 / 37
B2RXH2	Lysine-specific demethylase 4E	Enzyme	C00002525	0 / 0
P13866	Sodium/glucose cotransporter 1	Glucose	C00002525	1 / 1
P33527	Multidrug resistance-associated protein 1	drugs	C00002525	0 / 0
O94925	Glutaminase kidney isoform, mitochondrial	Enzyme	C00002525	0 / 0
Q13148	TAR DNA-binding protein 43	Unclassified protein	C00009577	1 / 1

19 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
5243	ABCB1, ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1	ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44)	C00002525 C00009575
54575	UGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J	UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17)	C00002525
1543	CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX	cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1)	C00002525
1545	CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1	cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1)	C00002525
2056	EPO, EP, MVCD2	erythropoietin	C00002525
2099	ESR1, ER, ESR, ESRA, ESTRR, Era, NR3A1	estrogen receptor 1	C00002525
2100	ESR2, ER-BETA, ESR-BETA, ESRB, ESTRB, Erb, NR3A2	estrogen receptor 2 (ER beta)	C00002525
3091	HIF1A, HIF-1A, HIF-1alpha, HIF1, HIF1-ALPHA, MOP1, PASD8, bHLHe78	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	C00002525
54658	UGT1A1, BILIQTL1, GNT1, HUG-BR1, UDPGT, UDPGT_1-1, UGT1, UGT1A	UDP glucuronosyltransferase 1 family, polypeptide A1 (EC:2.4.1.17)	C00002525
4363	ABCC1, ABC29, ABCC, GS-X, MRP, MRP1	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	C00002525
54577	UGT1A7, UDPGT, UDPGT_1-7, UGT-1G, UGT1-07, UGT1.7, UGT1G	UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17)	C00002525
54576	UGT1A8, UDPGT, UDPGT_1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H	UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17)	C00002525
54600	UGT1A9, HLUGP4, LUGP4, UDPGT, UDPGT_1-9, UGT-1I, UGT1-09, UGT1-9, UGT1.9, UGT1AI, UGT1I	UDP glucuronosyltransferase 1 family, polypeptide A9 (EC:2.4.1.17)	C00002525
329	BIRC2, API1, HIAP2, Hiap-2, MIHB, RNF48, c-IAP1, cIAP1	baculoviral IAP repeat containing 2	C00002578
330	BIRC3, AIP1, API2, CIAP2, HAIP1, HIAP1, MALT2, MIHC, RNF49, c-IAP2	baculoviral IAP repeat containing 3	C00002578
4318	MMP9, CLG4B, GELB, MANDP2, MMP-9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35)	C00002578
4843	NOS2, HEP-NOS, INOS, NOS, NOS2A	nitric oxide synthase 2, inducible (EC:1.14.13.39)	C00002578
5743	PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1)	C00002578
7124	TNF, DIF, TNF-alpha, TNFA, TNFSF2	tumor necrosis factor	C00002578

Related Diseases

Diseases related to proteins in ChEMBL interactions