KCF-S cluster No. 281 (24 metabolites)
Corresponding Phytochemical cluster No. 15
Plant Species
Cumulative plant class count
| class name | count |
|---|---|
| rosids | 62 |
| asterids | 3 |
Cumulative family count
| class name | count |
|---|---|
| Fabaceae | 61 |
| Convolvulaceae | 2 |
| Scrophulariaceae | 1 |
| Rhamnaceae | 1 |
Metabolite list (24)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
figure |
|---|---|---|---|---|---|---|
C00002537
|
Rotenolone
/ 12a-Hydroxyrotenone |
CHEMBL240545
|
|
|||
|
C00002568
|
Rotenone
/ Tubotoxin / Nicouline |
CHEMBL429023
CHEMBL267461 CHEMBL418710 CHEMBL1518927 |
D012402
|
129 / 92 / 86 | 177 / 42 |
|
|
C00002575
|
Sumatrol
|
CHEMBL518045
|
|
|||
|
C00009572
|
Isomillettone
|
|
||||
|
C00009575
|
Amorphigenin
/ 8'-Hydroxyrotenone |
CHEMBL465552
CHEMBL1447847 CHEMBL1490209 |
C049148
|
7 / 8 / 12 | 1 / 0 |
|
|
C00009576
|
Dihydroamorphigenin
/ 22,23-Dihydro-24-hydroxyrotenone |
|
||||
|
C00009577
|
Dalpanol
/ 6',7'-Dihydro-6'-hydroxyrotenone |
CHEMBL518129
CHEMBL1700300 |
3 / 3 / 1 |
|
||
|
C00009578
|
Villosin
/ 6-Hydroxysumatrol |
|
||||
|
C00009579
|
Amorphigenol
|
|
||||
|
C00009588
|
12a-Hydroxyisomillettone
|
|
||||
|
C00009589
|
12a-Methoxyrotenone
|
|
||||
|
C00009590
|
Dalbinol
|
CHEMBL465761
|
|
|||
|
C00009592
|
Villosinol
/ 12a-Hydroxysumatrol |
|
||||
|
C00009593
|
12-Dihydrodalbinol
|
|
||||
|
C00009594
|
Villol
/ 6,12a-Dihydroxysumatrol |
|
||||
|
C00009974
|
3-O-Demethylamorphigenin
|
|
||||
|
C00009977
|
6-Hydroxyrotenone
|
|
||||
|
C00009981
|
Volubinol
|
|
||||
|
C00018878
|
Dalcochinin
/ (12R)-12-Hydroxy-2,3-dimethoxy-5'-(1''-hydroxymethylethenyl)4',5'-dihydrofurano[2',3':9,8]rotenone |
|
||||
|
C00019215
|
Derrisin
/ (6aS,12aS,4'S,5'R)-4',5'-Dihydroxy-2,3,4'-dimethoxy-6',6'-dimethyl-4',5-dihydropyrano[2',3':9,8]rotenone |
CHEMBL464885
CHEMBL2181269 |
|
|||
|
C00019216
|
(1S,2R,7aR,13aR)-2,3,13,13a-Tetrahydro-1,2,7a-trihydroxy-9,10-dimethoxy-3,3-dimethyl-1H-bis[1]benzopyrano[3,4-b:6',5'-e]pyran-7(7aH)-one
|
CHEMBL516701
|
|
|||
|
C00019219
|
4',5'-Dihydro-11,5'-dihydroxy-4'-methoxytephrosin
|
CHEMBL510838
|
|
|||
|
C00019423
|
1,2,12,12a-Tetrahydro-2-isopropenyl-8,9-dimethoxy-[1]benzopyrano[3,4-b]furo[2,3-h][1]benzopyran-6(6aH)-one
|
CHEMBL429023
CHEMBL267461 CHEMBL418710 CHEMBL1518927 |
129 / 92 / 86 |
|
||
|
C00044049
|
12a-Hydroxyamorphigenin
|
CHEMBL515078
|
C044989
|
|
Human Protein / Gene in interactions
133 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00002568 C00009575 C00019423 | 0 / 0 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00002568 C00009577 C00019423 | 0 / 0 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00002568 C00009575 C00019423 | 4 / 3 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00002568 C00009575 C00019423 | 0 / 1 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00002568 C00009575 C00019423 | 1 / 1 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00002568 C00009575 C00019423 | 0 / 0 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00002568 C00019423 | 0 / 0 |
| P35354 | Prostaglandin G/H synthase 2 | Oxidoreductase | C00002568 C00019423 | 0 / 3 |
| Q12809 | Potassium voltage-gated channel subfamily H member 2 | KCNH, Kv10-12.x (Ether-a-go-go) | C00002568 C00019423 | 2 / 2 |
| P08246 | Neutrophil elastase | S1A | C00002568 C00019423 | 2 / 1 |
| P33765 | Adenosine receptor A3 | Adenosine receptor | C00002568 C00019423 | 0 / 0 |
| Q16539 | Mitogen-activated protein kinase 14 | p38 | C00002568 C00019423 | 0 / 0 |
| P06746 | DNA polymerase beta | Enzyme | C00002568 C00019423 | 0 / 0 |
| P49146 | Neuropeptide Y receptor type 2 | Neuropeptide Y receptor | C00002568 C00019423 | 0 / 0 |
| P29466 | Caspase-1 | C14 | C00002568 C00019423 | 0 / 0 |
| P17252 | Protein kinase C alpha type | Alpha | C00002568 C00019423 | 0 / 0 |
| P27361 | Mitogen-activated protein kinase 3 | Erk | C00002568 C00019423 | 0 / 0 |
| Q03181 | Peroxisome proliferator-activated receptor delta | NR1C2 | C00002568 C00019423 | 0 / 0 |
| P14780 | Matrix metalloproteinase-9 | M10A | C00002568 C00019423 | 2 / 2 |
| O75604 | Ubiquitin carboxyl-terminal hydrolase 2 | Enzyme | C00002568 C00019423 | 0 / 0 |
| P02545 | Prelamin-A/C | Unclassified protein | C00002568 C00019423 | 11 / 10 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | C00002568 C00019423 | 3 / 2 |
| P10828 | Thyroid hormone receptor beta | NR1A2 | C00002568 C00019423 | 3 / 1 |
| P19793 | Retinoic acid receptor RXR-alpha | NR2B1 | C00002568 C00019423 | 0 / 0 |
| P00918 | Carbonic anhydrase 2 | Lyase | C00002568 C00019423 | 1 / 2 |
| P07550 | Beta-2 adrenergic receptor | Adrenergic receptor | C00002568 C00019423 | 0 / 1 |
| P21397 | Amine oxidase [flavin-containing] A | Oxidoreductase | C00002568 C00019423 | 1 / 1 |
| P25021 | Histamine H2 receptor | Histamine receptor | C00002568 C00019423 | 0 / 0 |
| P35367 | Histamine H1 receptor | Histamine receptor | C00002568 C00019423 | 0 / 0 |
| Q01959 | Sodium-dependent dopamine transporter | Dopamine | C00002568 C00019423 | 1 / 0 |
| P08912 | Muscarinic acetylcholine receptor M5 | Acetylcholine receptor | C00002568 C00019423 | 0 / 0 |
| P18825 | Alpha-2C adrenergic receptor | Adrenergic receptor | C00002568 C00019423 | 0 / 0 |
| P13945 | Beta-3 adrenergic receptor | Adrenergic receptor | C00002568 C00019423 | 0 / 0 |
| P25024 | C-X-C chemokine receptor type 1 | CXC chemokine receptor | C00002568 C00019423 | 0 / 0 |
| P06241 | Tyrosine-protein kinase Fyn | Src | C00002568 C00019423 | 0 / 0 |
| P06493 | Cyclin-dependent kinase 1 | Cdc2 | C00002568 C00019423 | 0 / 0 |
| Q08209 | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform | Ser_Thr | C00002568 C00019423 | 0 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00002568 C00019423 | 0 / 1 |
| P54132 | Bloom syndrome protein | Enzyme | C00002568 C00019423 | 1 / 2 |
| P00533 | Epidermal growth factor receptor | TK tyrosine-protein kinase EGFR subfamily | C00002568 C00019423 | 1 / 8 |
| P14416 | D(2) dopamine receptor | Dopamine receptor | C00002568 C00019423 | 2 / 0 |
| P23219 | Prostaglandin G/H synthase 1 | Oxidoreductase | C00002568 C00019423 | 0 / 0 |
| P37288 | Vasopressin V1a receptor | Vasopressin and oxytocin receptor | C00002568 C00019423 | 0 / 0 |
| P41145 | Kappa-type opioid receptor | Opioid receptor | C00002568 C00019423 | 0 / 0 |
| Q9Y271 | Cysteinyl leukotriene receptor 1 | Leukotriene receptor | C00002568 C00019423 | 0 / 0 |
| P29274 | Adenosine receptor A2a | Adenosine receptor | C00002568 C00019423 | 0 / 0 |
| P25929 | Neuropeptide Y receptor type 1 | Neuropeptide Y receptor | C00002568 C00019423 | 0 / 0 |
| P50052 | Type-2 angiotensin II receptor | Angiotensin receptor | C00002568 C00019423 | 1 / 1 |
| P17948 | Vascular endothelial growth factor receptor 1 | Vegfr | C00002568 C00019423 | 0 / 0 |
| P41968 | Melanocortin receptor 3 | Melanocortin receptor | C00002568 C00019423 | 1 / 0 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00002568 C00019423 | 1 / 0 |
| P11509 | Cytochrome P450 2A6 | Cytochrome P450 2A6 | C00002568 C00019423 | 0 / 0 |
| Q16665 | Hypoxia-inducible factor 1-alpha | Transcription Factor | C00002568 C00019423 | 0 / 0 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00002568 C00019423 | 1 / 1 |
| O75496 | Geminin | Unclassified protein | C00002568 C00019423 | 0 / 0 |
| P51151 | Ras-related protein Rab-9A | Unclassified protein | C00002568 C00019423 | 0 / 0 |
| P23528 | Cofilin-1 | Unclassified protein | C00002568 C00019423 | 0 / 0 |
| P04035 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | Oxidoreductase | C00002568 C00019423 | 0 / 0 |
| P08913 | Alpha-2A adrenergic receptor | Adrenergic receptor | C00002568 C00019423 | 0 / 0 |
| P21917 | D(4) dopamine receptor | Dopamine receptor | C00002568 C00019423 | 0 / 0 |
| P30988 | Calcitonin receptor | Calcitonin receptor | C00002568 C00019423 | 0 / 0 |
| P35462 | D(3) dopamine receptor | Dopamine receptor | C00002568 C00019423 | 1 / 0 |
| P41143 | Delta-type opioid receptor | Opioid receptor | C00002568 C00019423 | 0 / 0 |
| Q92731 | Estrogen receptor beta | NR3A2 | C00002568 C00019423 | 0 / 1 |
| P41595 | 5-hydroxytryptamine receptor 2B | Serotonin receptor | C00002568 C00019423 | 0 / 0 |
| P25101 | Endothelin-1 receptor | Endothelin receptor | C00002568 C00019423 | 0 / 0 |
| P30411 | B2 bradykinin receptor | Bradykinin receptor | C00002568 C00019423 | 0 / 0 |
| P32245 | Melanocortin receptor 4 | Melanocortin receptor | C00002568 C00019423 | 1 / 0 |
| P32238 | Cholecystokinin receptor type A | Cholecystokinin receptor | C00002568 C00019423 | 0 / 0 |
| P08311 | Cathepsin G | S1A | C00002568 C00019423 | 0 / 0 |
| Q99720 | Sigma non-opioid intracellular receptor 1 | Membrane receptor | C00002568 C00019423 | 1 / 0 |
| P03956 | Interstitial collagenase | M10A | C00002568 C00019423 | 0 / 1 |
| P32241 | Vasoactive intestinal polypeptide receptor 1 | Vasoactive intestinal peptide receptor | C00002568 C00019423 | 0 / 0 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00002568 C00019423 | 0 / 0 |
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | C00002568 C00019423 | 0 / 0 |
| P04150 | Glucocorticoid receptor | NR3C1 | C00002568 C00019423 | 0 / 1 |
| P08172 | Muscarinic acetylcholine receptor M2 | Acetylcholine receptor | C00002568 C00019423 | 2 / 0 |
| P11229 | Muscarinic acetylcholine receptor M1 | Acetylcholine receptor | C00002568 C00019423 | 0 / 0 |
| P21554 | Cannabinoid receptor 1 | Cannabinoid receptor | C00002568 C00019423 | 0 / 0 |
| P31645 | Sodium-dependent serotonin transporter | Serotonin | C00002568 C00019423 | 2 / 0 |
| P37231 | Peroxisome proliferator-activated receptor gamma | NR1C3 | C00002568 C00019423 | 5 / 3 |
| P04626 | Receptor tyrosine-protein kinase erbB-2 | TK tyrosine-protein kinase EGFR subfamily | C00002568 C00019423 | 5 / 9 |
| P20309 | Muscarinic acetylcholine receptor M3 | Acetylcholine receptor | C00002568 C00019423 | 1 / 0 |
| P21452 | Substance-K receptor | Neurokinin receptor | C00002568 C00019423 | 0 / 0 |
| P51679 | C-C chemokine receptor type 4 | CC chemokine receptor | C00002568 C00019423 | 0 / 0 |
| P51681 | C-C chemokine receptor type 5 | CC chemokine receptor | C00002568 C00019423 | 3 / 0 |
| P50406 | 5-hydroxytryptamine receptor 6 | Serotonin receptor | C00002568 C00019423 | 0 / 0 |
| P41597 | C-C chemokine receptor type 2 | CC chemokine receptor | C00002568 C00019423 | 1 / 0 |
| P49798 | Regulator of G-protein signaling 4 | Unclassified protein | C00002568 C00019423 | 2 / 0 |
| P08575 | Receptor-type tyrosine-protein phosphatase C | Enzyme | C00002568 C00019423 | 2 / 1 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00002568 C00019423 | 0 / 0 |
| P03905 | NADH-ubiquinone oxidoreductase chain 4 | Oxidoreductase | C00002568 C00019423 | 3 / 1 |
| Q92887 | Canalicular multispecific organic anion transporter 1 | Unclassified protein | C00002568 C00019423 | 1 / 1 |
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | C00002568 C00019423 | 2 / 2 |
| O15118 | Niemann-Pick C1 protein | Unclassified protein | C00002568 C00019423 | 1 / 1 |
| Q01453 | Peripheral myelin protein 22 | Unclassified protein | C00002568 C00019423 | 5 / 2 |
| P21728 | D(1A) dopamine receptor | Dopamine receptor | C00002568 C00019423 | 0 / 0 |
| O76074 | cGMP-specific 3',5'-cyclic phosphodiesterase | PDE_5A | C00002568 C00019423 | 0 / 0 |
| P03372 | Estrogen receptor | NR3A1 | C00002568 C00019423 | 1 / 1 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00002568 C00019423 | 0 / 0 |
| P22303 | Acetylcholinesterase | Hydrolase | C00002568 C00019423 | 1 / 0 |
| P28223 | 5-hydroxytryptamine receptor 2A | Serotonin receptor | C00002568 C00019423 | 0 / 0 |
| P28335 | 5-hydroxytryptamine receptor 2C | Serotonin receptor | C00002568 C00019423 | 0 / 0 |
| P35372 | Mu-type opioid receptor | Opioid receptor | C00002568 C00019423 | 0 / 0 |
| P08173 | Muscarinic acetylcholine receptor M4 | Acetylcholine receptor | C00002568 C00019423 | 0 / 0 |
| P25103 | Substance-P receptor | Neurokinin receptor | C00002568 C00019423 | 0 / 0 |
| P25105 | Platelet-activating factor receptor | PAF receptor | C00002568 C00019423 | 0 / 0 |
| P33032 | Melanocortin receptor 5 | Melanocortin receptor | C00002568 C00019423 | 0 / 0 |
| Q99700 | Ataxin-2 | Unclassified protein | C00002568 C00019423 | 1 / 1 |
| Q16637 | Survival motor neuron protein | Unclassified protein | C00002568 C00019423 | 4 / 1 |
| P05181 | Cytochrome P450 2E1 | Cytochrome P450 2E1 | C00002568 C00019423 | 0 / 0 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00002568 C00019423 | 0 / 0 |
| Q6W5P4 | Neuropeptide S receptor | Neuropeptide receptor | C00002568 C00019423 | 1 / 0 |
| P04637 | Cellular tumor antigen p53 | Transcription Factor | C00002568 C00019423 | 7 / 37 |
| Q99549 | M-phase phosphoprotein 8 | Unclassified protein | C00002568 C00019423 | 0 / 0 |
| P42345 | Serine/threonine-protein kinase mTOR | Enzyme | C00002568 C00019423 | 0 / 0 |
| P10275 | Androgen receptor | NR3C4 | C00002568 C00019423 | 3 / 4 |
| P23975 | Sodium-dependent noradrenaline transporter | Norepinephrine | C00002568 C00019423 | 1 / 1 |
| P25100 | Alpha-1D adrenergic receptor | Adrenergic receptor | C00002568 C00019423 | 0 / 0 |
| P30542 | Adenosine receptor A1 | Adenosine receptor | C00002568 C00019423 | 0 / 0 |
| P18089 | Alpha-2B adrenergic receptor | Adrenergic receptor | C00002568 C00019423 | 0 / 0 |
| P24557 | Thromboxane-A synthase | Cytochrome P450 5A1 | C00002568 C00019423 | 1 / 1 |
| P05412 | Transcription factor AP-1 | Transcription Factor | C00002568 C00019423 | 0 / 0 |
| P06239 | Tyrosine-protein kinase Lck | Src | C00002568 C00019423 | 0 / 1 |
| P25025 | C-X-C chemokine receptor type 2 | CXC chemokine receptor | C00002568 C00019423 | 0 / 0 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00002568 C00019423 | 0 / 0 |
| P46063 | ATP-dependent DNA helicase Q1 | Enzyme | C00002568 C00019423 | 0 / 0 |
| P40225 | Thrombopoietin | Unclassified protein | C00002568 C00019423 | 1 / 1 |
| P08588 | Beta-1 adrenergic receptor | Adrenergic receptor | C00002568 C00019423 | 1 / 0 |
| P84022 | Mothers against decapentaplegic homolog 3 | Unclassified protein | C00009577 | 2 / 0 |
| O00255 | Menin | Unclassified protein | C00009575 | 2 / 5 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00009575 | 1 / 2 |
| Q13148 | TAR DNA-binding protein 43 | Unclassified protein | C00009577 | 1 / 1 |
177 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 5243 | ABCB1, ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1 | ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) |
C00002568
C00009575
|
| 5163 | PDK1 | pyruvate dehydrogenase kinase, isozyme 1 (EC:2.7.11.2) |
C00002568
|
| 48 | ACO1, ACONS, IREB1, IREBP, IREBP1, IRP1 | aconitase 1, soluble (EC:4.2.1.3) |
C00002568
|
| 50 | ACO2, ACONM, ICRD | aconitase 2, mitochondrial (EC:4.2.1.3) |
C00002568
|
| 54 | ACP5, SPENCDI, TRAP | acid phosphatase 5, tartrate resistant (EC:3.1.3.2) |
C00002568
|
| 59 | ACTA2, AAT6, ACTSA, MYMY5 | actin, alpha 2, smooth muscle, aorta |
C00002568
|
| 183 | AGT, ANHU, SERPINA8 | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) |
C00002568
|
| 9131 | AIFM1, AIF, CMTX4, COWCK, COXPD6, PDCD8 | apoptosis-inducing factor, mitochondrion-associated, 1 |
C00002568
|
| 290 | ANPEP, APN, CD13, GP150, LAP1, P150, PEPN | alanyl (membrane) aminopeptidase (EC:3.4.11.2) |
C00002568
|
| 317 | APAF1, APAF-1, CED4 | apoptotic peptidase activating factor 1 |
C00002568
|
| 402 | ARL2, ARFL2 | ADP-ribosylation factor-like 2 |
C00002568
|
| 468 | ATF4, CREB-2, CREB2, TAXREB67, TXREB | activating transcription factor 4 |
C00002568
|
| 9474 | ATG5, APG5, APG5-LIKE, APG5L, ASP, hAPG5 | autophagy related 5 |
C00002568
|
| 472 | ATM, AT1, ATA, ATC, ATD, ATDC, ATE, TEL1, TELO1 | ataxia telangiectasia mutated (EC:2.7.11.1) |
C00002568
|
| 514 | ATP5E, ATPE, MC5DN3 | ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit (EC:3.6.3.14) |
C00002568
|
| 518 | ATP5G3, P3 | ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9) |
C00002568
|
| 521 | ATP5I, ATP5K | ATP synthase, H+ transporting, mitochondrial Fo complex, subunit E (EC:3.6.1.14) |
C00002568
|
| 522 | ATP5J, ATP5, ATP5A, ATPM, CF6, F6 | ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6 (EC:3.6.1.14) |
C00002568
|
| 10632 | ATP5L, ATP5JG | ATP synthase, H+ transporting, mitochondrial Fo complex, subunit G (EC:3.6.1.14) |
C00002568
|
| 539 | ATP5O, ATPO, OSCP | ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit (EC:3.6.3.14) |
C00002568
|
| 545 | ATR, FCTCS, FRP1, MEC1, SCKL, SCKL1 | ataxia telangiectasia and Rad3 related (EC:2.7.11.1) |
C00002568
|
| 4287 | ATXN3, AT3, ATX3, JOS, MJD, MJD1, SCA3 | ataxin 3 (EC:3.4.19.12) |
C00002568
|
| 23621 | BACE1, ASP2, BACE, HSPC104 | beta-site APP-cleaving enzyme 1 (EC:3.4.23.46) |
C00002568
|
| 572 | BAD, BBC2, BCL2L8 | BCL2-associated agonist of cell death |
C00002568
|
| 580 | BARD1 | BRCA1 associated RING domain 1 |
C00002568
|
| 581 | BAX, BCL2L4 | BCL2-associated X protein |
C00002568
|
| 596 | BCL2, Bcl-2, PPP1R50 | B-cell CLL/lymphoma 2 |
C00002568
|
| 8678 | BECN1, ATG6, VPS30, beclin1 | beclin 1, autophagy related |
C00002568
|
| 330 | BIRC3, AIP1, API2, CIAP2, HAIP1, HIAP1, MALT2, MIHC, RNF49, c-IAP2 | baculoviral IAP repeat containing 3 |
C00002568
|
| 672 | BRCA1, BRCAI, BRCC1, BROVCA1, IRIS, PNCA4, PPP1R53, PSCP, RNF53 | breast cancer 1, early onset |
C00002568
|
| 675 | BRCA2, BRCC2, BROVCA2, FACD, FAD, FAD1, FANCB, FANCD, FANCD1, GLM3, PNCA2 | breast cancer 2, early onset |
C00002568
|
| 701 | BUB1B, BUB1beta, BUBR1, Bub1A, MAD3L, MVA1, SSK1, hBUBR1 | BUB1 mitotic checkpoint serine/threonine kinase B (EC:2.7.11.1) |
C00002568
|
| 836 | CASP3, CPP32, CPP32B, SCA-1 | caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) |
C00002568
|
| 840 | CASP7, CASP-7, CMH-1, ICE-LAP3, LICE2, MCH3 | caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) |
C00002568
|
| 842 | CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56 | caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) |
C00002568
|
| 847 | CAT | catalase (EC:1.11.1.6) |
C00002568
|
| 595 | CCND1, BCL1, D11S287E, PRAD1, U21B31 | cyclin D1 |
C00002568
|
| 902 | CCNH, CAK, p34, p37 | cyclin H |
C00002568
|
| 929 | CD14 | CD14 molecule |
C00002568
|
| 948 | CD36, BDPLT10, CHDS7, FAT, GP3B, GP4, GPIV, PASIV, SCARB3 | CD36 molecule (thrombospondin receptor) |
C00002568
|
| 952 | CD38, T10 | CD38 molecule (EC:3.2.2.5) |
C00002568
|
| 999 | CDH1, Arc-1, CD324, CDHE, ECAD, LCAM, UVO | cadherin 1, type 1, E-cadherin (epithelial) |
C00002568
|
| 1026 | CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 | cyclin-dependent kinase inhibitor 1A (p21, Cip1) |
C00002568
|
| 1111 | CHEK1, CHK1 | checkpoint kinase 1 (EC:2.7.11.1) |
C00002568
|
| 29883 | CNOT7, CAF1, Caf1a, hCAF-1 | CCR4-NOT transcription complex, subunit 7 (EC:3.1.13.4) |
C00002568
|
| 1270 | CNTF, HCNTF | ciliary neurotrophic factor |
C00002568
|
| 1293 | COL6A3 | collagen, type VI, alpha 3 |
C00002568
|
| 1327 | COX4I1, COX4, COX4-1, COXIV | cytochrome c oxidase subunit IV isoform 1 (EC:1.9.3.1) |
C00002568
|
| 9377 | COX5A, COX, COX-VA, VA | cytochrome c oxidase subunit Va (EC:1.9.3.1) |
C00002568
|
| 1329 | COX5B, COXVB | cytochrome c oxidase subunit Vb (EC:1.9.3.1) |
C00002568
|
| 1347 | COX7A2, COX7AL, COX7AL1, COXVIIAL, COXVIIa-L, VIIAL | cytochrome c oxidase subunit VIIa polypeptide 2 (liver) (EC:1.9.3.1) |
C00002568
|
| 1349 | COX7B, APLCC | cytochrome c oxidase subunit VIIb (EC:1.9.3.1) |
C00002568
|
| 1356 | CP, CP-2 | ceruloplasmin (ferroxidase) (EC:1.16.3.1) |
C00002568
|
| 1588 | CYP19A1, ARO, ARO1, CPV1, CYAR, CYP19, CYPXIX, P-450AROM | cytochrome P450, family 19, subfamily A, polypeptide 1 (EC:1.14.14.1) |
C00002568
|
| 1649 | DDIT3, CEBPZ, CHOP, CHOP-10, CHOP10, GADD153 | DNA-damage-inducible transcript 3 |
C00002568
|
| 1677 | DFFB, CAD, CPAN, DFF-40, DFF2, DFF40 | DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase) |
C00002568
|
| 10072 | DPP3, DPPIII | dipeptidyl-peptidase 3 (EC:3.4.14.4) |
C00002568
|
| 9451 | EIF2AK3, PEK, PERK, WRS | eukaryotic translation initiation factor 2-alpha kinase 3 (EC:2.7.11.1) |
C00002568
|
| 1965 | EIF2S1, EIF-2, EIF-2A, EIF-2alpha, EIF2, EIF2A | eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa |
C00002568
|
| 9156 | EXO1, HEX1, hExoI | exonuclease 1 |
C00002568
|
| 2175 | FANCA, FA, FA-H, FA1, FAA, FACA, FAH, FANCH | Fanconi anemia, complementation group A |
C00002568
|
| 2176 | FANCC, FA3, FAC, FACC | Fanconi anemia, complementation group C |
C00002568
|
| 2177 | FANCD2, FA-D2, FA4, FACD, FAD, FAD2, FANCD | Fanconi anemia, complementation group D2 |
C00002568
|
| 2178 | FANCE, FACE, FAE | Fanconi anemia, complementation group E |
C00002568
|
| 2188 | FANCF, FAF | Fanconi anemia, complementation group F |
C00002568
|
| 2189 | FANCG, FAG, XRCC9 | Fanconi anemia, complementation group G |
C00002568
|
| 355 | FAS, ALPS1A, APO-1, APT1, CD95, FAS1, FASTM, TNFRSF6 | Fas cell surface death receptor |
C00002568
|
| 2335 | FN1, CIG, ED-B, FINC, FN, FNZ, GFND, GFND2, LETS, MSF | fibronectin 1 |
C00002568
|
| 2353 | FOS, AP-1, C-FOS, p55 | FBJ murine osteosarcoma viral oncogene homolog |
C00002568
|
| 2495 | FTH1, FHC, FTH, FTHL6, PIG15, PLIF | ferritin, heavy polypeptide 1 (EC:1.16.3.1) |
C00002568
|
| 2876 | GPX1, GPXD, GSHPX1 | glutathione peroxidase 1 (EC:1.11.1.9) |
C00002568
|
| 10456 | HAX1, HCLSBP1, HS1BP1, SCN3 | HCLS1 associated protein X-1 |
C00002568
|
| 3091 | HIF1A, HIF-1A, HIF-1alpha, HIF1, HIF1-ALPHA, MOP1, PASD8, bHLHe78 | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) |
C00002568
|
| 3162 | HMOX1, HMOX1D, HO-1, HSP32, bK286B10 | heme oxygenase (decycling) 1 (EC:1.14.99.3) |
C00002568
|
| 3313 | HSPA9, CSA, GRP-75, GRP75, HSPA9B, MOT, MOT2, MTHSP75, PBP74 | heat shock 70kDa protein 9 (mortalin) |
C00002568
|
| 27429 | HTRA2, OMI, PARK13, PRSS25 | HtrA serine peptidase 2 (EC:3.4.21.108) |
C00002568
|
| 3364 | HUS1, hHUS1 | HUS1 checkpoint homolog (S. pombe) |
C00002568
|
| 3383 | ICAM1, BB2, CD54, P3.58 | intercellular adhesion molecule 1 |
C00002568
|
| 3419 | IDH3A | isocitrate dehydrogenase 3 (NAD+) alpha (EC:1.1.1.41) |
C00002568
|
| 3458 | IFNG, IFG, IFI | interferon, gamma |
C00002568
|
| 3479 | IGF1, IGF-I, IGF1A, IGFI | insulin-like growth factor 1 (somatomedin C) |
C00002568
|
| 3569 | IL6, BSF2, HGF, HSF, IFNB2, IL-6 | interleukin 6 (interferon, beta 2) |
C00002568
|
| 3576 | IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 | interleukin 8 |
C00002568
|
| 3716 | JAK1, JAK1A, JAK1B, JTK3 | Janus kinase 1 (EC:2.7.10.2) |
C00002568
|
| 3717 | JAK2, JTK10, THCYT3 | Janus kinase 2 (EC:2.7.10.2) |
C00002568
|
| 3725 | JUN, AP-1, AP1, c-Jun | jun proto-oncogene |
C00002568
|
| 3952 | LEP, LEPD, OB, OBS | leptin |
C00002568
|
| 120892 | LRRK2, AURA17, DARDARIN, PARK8, RIPK7, ROCO2 | leucine-rich repeat kinase 2 (EC:2.7.11.1) |
C00002568
|
| 5594 | MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk | mitogen-activated protein kinase 1 (EC:2.7.11.24) |
C00002568
|
| 1432 | MAPK14, CSBP, CSBP1, CSBP2, CSPB1, EXIP, Mxi2, PRKM14, PRKM15, RK, SAPK2A, p38, p38ALPHA | mitogen-activated protein kinase 14 (EC:2.7.11.24) |
C00002568
|
| 5595 | MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK | mitogen-activated protein kinase 3 (EC:2.7.11.24) |
C00002568
|
| 5599 | MAPK8, JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c | mitogen-activated protein kinase 8 (EC:2.7.11.24) |
C00002568
|
| 4137 | MAPT, DDPAC, FTDP-17, MAPTL, MSTD, MTBT1, MTBT2, PPND, TAU | microtubule-associated protein tau |
C00002568
|
| 4313 | MMP2, CLG4, CLG4A, MMP-II, MONA, TBE-1 | matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24) |
C00002568
|
| 4361 | MRE11A, ATLD, HNGS1, MRE11, MRE11B | MRE11 meiotic recombination 11 homolog A (S. cerevisiae) |
C00002568
|
| 64965 | MRPS9, MRP-S9, RPMS9, S9mt | mitochondrial ribosomal protein S9 |
C00002568
|
| 4481 | MSR1, CD204, SCARA1, SR-A, SRA, phSR1, phSR2 | macrophage scavenger receptor 1 |
C00002568
|
| 4490 | MT1B, MT1, MT1Q, MTP | metallothionein 1B |
C00002568
|
| 4502 | MT2A, MT2 | metallothionein 2A |
C00002568
|
| 80198 | MUS81, SLX3 | MUS81 structure-specific endonuclease subunit (EC:3.1.22.-) |
C00002568
|
| 10135 | NAMPT, 1110035O14Rik, PBEF, PBEF1, VF, VISFATIN | nicotinamide phosphoribosyltransferase (EC:2.4.2.12) |
C00002568
|
| 4541 | ND6, MTND6, MT-ND6 | NADH dehydrogenase, subunit 6 (complex I) |
C00002568
|
| 4705 | NDUFA10, CI-42KD, CI-42k | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa (EC:1.6.5.3 1.6.99.3) |
C00002568
|
| 4696 | NDUFA3, B9, CI-B9 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa |
C00002568
|
| 4697 | NDUFA4, CI-9k, CI-MLRQ, MLRQ | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4, 9kDa (EC:1.6.5.3 1.6.99.3) |
C00002568
|
| 4700 | NDUFA6, B14, CI-B14, LYRM6, NADHB14 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 6, 14kDa |
C00002568
|
| 4704 | NDUFA9, CC6, CI-39k, CI39k, NDUFS2L, SDR22E1 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa |
C00002568
|
| 4707 | NDUFB1, CI-MNLL, CI-SGDH, MNLL | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1, 7kDa |
C00002568
|
| 4708 | NDUFB2, AGGG, CI-AGGG | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8kDa (EC:1.6.5.3 1.6.99.3) |
C00002568
|
| 4709 | NDUFB3, B12, CI-B12 | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa |
C00002568
|
| 4710 | NDUFB4, B15, CI-B15 | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4, 15kDa (EC:1.6.5.3 1.6.99.3) |
C00002568
|
| 4711 | NDUFB5, CISGDH, SGDH | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa (EC:1.6.5.3 1.6.99.3) |
C00002568
|
| 4712 | NDUFB6, B17, CI | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6, 17kDa (EC:1.6.5.3 1.6.99.3) |
C00002568
|
| 4713 | NDUFB7, B18, CI-B18 | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa (EC:1.6.5.3 1.6.99.3) |
C00002568
|
| 4714 | NDUFB8, ASHI, CI-ASHI | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa |
C00002568
|
| 4724 | NDUFS4, AQDQ, CI-18 | NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase) |
C00002568
|
| 4726 | NDUFS6, CI-13kA, CI-13kD-A, CI13KDA | NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase) (EC:1.6.5.3 1.6.99.3) |
C00002568
|
| 4728 | NDUFS8, CI-23k, CI23KD, TYKY | NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase) (EC:1.6.5.3 1.6.99.3) |
C00002568
|
| 10725 | NFAT5, NF-AT5, NFATL1, NFATZ, OREBP, TONEBP | nuclear factor of activated T-cells 5, tonicity-responsive |
C00002568
|
| 4772 | NFATC1, NF-ATC, NFAT2, NFATc | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 |
C00002568
|
| 4780 | NFE2L2, NRF2 | nuclear factor, erythroid 2-like 2 |
C00002568
|
| 4790 | NFKB1, EBP-1, KBF1, NF-kB1, NF-kappa-B, NF-kappaB, NFKB-p105, NFKB-p50, NFkappaB, p105, p50 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 |
C00002568
|
| 4846 | NOS3, ECNOS, eNOS | nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) |
C00002568
|
| 4879 | NPPB, BNP | natriuretic peptide B |
C00002568
|
| 4521 | NUDT1, MTH1 | nudix (nucleoside diphosphate linked moiety X)-type motif 1 (EC:3.6.1.55 3.6.1.56) |
C00002568
|
| 4953 | ODC1, ODC | ornithine decarboxylase 1 (EC:4.1.1.17) |
C00002568
|
| 4976 | OPA1, MGM1, NPG, NTG, largeG | optic atrophy 1 (autosomal dominant) (EC:3.6.5.5) |
C00002568
|
| 126014 | OSCAR, PIGR3, PIgR-3 | osteoclast associated, immunoglobulin-like receptor |
C00002568
|
| 5071 | PARK2, AR-JP, LPRS2, PDJ, PRKN | parkin RBR E3 ubiquitin protein ligase |
C00002568
|
| 11315 | PARK7, DJ-1, DJ1 | parkinson protein 7 |
C00002568
|
| 142 | PARP1, ADPRT, ADPRT_1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1 | poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) |
C00002568
|
| 5162 | PDHB, PDHBD, PDHE1-B, PHE1B | pyruvate dehydrogenase (lipoamide) beta (EC:1.2.4.1) |
C00002568
|
| 28976 | ACAD9, NPD002 | acyl-CoA dehydrogenase family, member 9 |
C00002568
|
| 65018 | PINK1, BRPK, PARK6 | PTEN induced putative kinase 1 (EC:2.7.11.1) |
C00002568
|
| 5422 | POLA1, POLA, p180 | polymerase (DNA directed), alpha 1, catalytic subunit (EC:2.7.7.7) |
C00002568
|
| 5427 | POLE2, DPE2 | polymerase (DNA directed), epsilon 2, accessory subunit (EC:2.7.7.7) |
C00002568
|
| 5481 | PPID, CYP-40, CYPD | peptidylprolyl isomerase D (EC:5.2.1.8) |
C00002568
|
| 5562 | PRKAA1, AMPK, AMPKa1 | protein kinase, AMP-activated, alpha 1 catalytic subunit (EC:2.7.11.1 2.7.11.26 2.7.11.27 2.7.11.31) |
C00002568
|
| 8842 | PROM1, AC133, CD133, CORD12, MCDR2, PROML1, RP41, STGD4 | prominin 1 |
C00002568
|
| 5810 | RAD1, HRAD1, REC1 | RAD1 homolog (S. pombe) (EC:3.1.11.2) |
C00002568
|
| 5884 | RAD17, CCYC, HRAD17, R24L, RAD17SP, RAD24 | RAD17 homolog (S. pombe) |
C00002568
|
| 56852 | RAD18, RNF73 | RAD18 homolog (S. cerevisiae) |
C00002568
|
| 10111 | RAD50, NBSLD, RAD502, hRad50 | RAD50 homolog (S. cerevisiae) |
C00002568
|
| 5888 | RAD51, BRCC5, HRAD51, HsRad51, HsT16930, MRMV2, RAD51A, RECA | RAD51 recombinase |
C00002568
|
| 10635 | RAD51AP1, PIR51 | RAD51 associated protein 1 |
C00002568
|
| 25788 | RAD54B, RDH54 | RAD54 homolog B (S. cerevisiae) |
C00002568
|
| 5883 | RAD9A, RAD9 | RAD9 homolog A (S. pombe) (EC:3.1.11.2) |
C00002568
|
| 5970 | RELA, NFKB3, p65 | v-rel avian reticuloendotheliosis viral oncogene homolog A |
C00002568
|
| 5984 | RFC4, A1, RFC37 | replication factor C (activator 1) 4, 37kDa |
C00002568
|
| 5985 | RFC5, RFC36 | replication factor C (activator 1) 5, 36.5kDa |
C00002568
|
| 6513 | SLC2A1, DYT17, DYT18, DYT9, EIG12, GLUT, GLUT1, GLUT1DS, HTLVR, PED | solute carrier family 2 (facilitated glucose transporter), member 1 |
C00002568
|
| 6539 | SLC6A12, BGT-1, BGT1, GAT2 | solute carrier family 6 (neurotransmitter transporter), member 12 |
C00002568
|
| 6531 | SLC6A3, DAT, DAT1, PKDYS | solute carrier family 6 (neurotransmitter transporter), member 3 |
C00002568
|
| 6606 | SMN1, BCD541, GEMIN1, SMA, SMA1, SMA2, SMA3, SMA4, SMA@, SMN, SMNT, T-BCD541, TDRD16A | survival of motor neuron 1, telomeric |
C00002568
|
| 6615 | SNAI1, SLUGH2, SNA, SNAH, SNAIL, SNAIL1, dJ710H13.1 | snail family zinc finger 1 |
C00002568
|
| 6622 | SNCA, NACP, PARK1, PARK4, PD1 | synuclein, alpha (non A4 component of amyloid precursor) |
C00002568
|
| 6648 | SOD2, IPOB, MNSOD, MVCD6 | superoxide dismutase 2, mitochondrial (EC:1.15.1.1) |
C00002568
|
| 8878 | SQSTM1, A170, OSIL, PDB3, ZIP3, p60, p62, p62B | sequestosome 1 |
C00002568
|
| 6720 | SREBF1, SREBP-1c, SREBP1, bHLHd1 | sterol regulatory element binding transcription factor 1 |
C00002568
|
| 6742 | SSBP1, Mt-SSB, SOSS-B1, SSBP, mtSSB | single-stranded DNA binding protein 1, mitochondrial |
C00002568
|
| 6772 | STAT1, CANDF7, ISGF-3, STAT91 | signal transducer and activator of transcription 1, 91kDa |
C00002568
|
| 6774 | STAT3, APRF, HIES | signal transducer and activator of transcription 3 (acute-phase response factor) |
C00002568
|
| 7084 | TK2, MTDPS2, MTTK | thymidine kinase 2, mitochondrial (EC:2.7.1.21) |
C00002568
|
| 7124 | TNF, DIF, TNF-alpha, TNFA, TNFSF2 | tumor necrosis factor |
C00002568
|
| 4982 | TNFRSF11B, OCIF, OPG, TR1 | tumor necrosis factor receptor superfamily, member 11b |
C00002568
|
| 8600 | TNFSF11, CD254, ODF, OPGL, OPTB2, RANKL, TRANCE, hRANKL2, sOdf | tumor necrosis factor (ligand) superfamily, member 11 |
C00002568
|
| 7157 | TP53, BCC7, LFS1, P53, TRP53 | tumor protein p53 |
C00002568
|
| 25828 | TXN2, MT-TRX, MTRX, TRX2 | thioredoxin 2 |
C00002568
|
| 7334 | UBE2N, UBC13, UbcH-ben, UbcH13 | ubiquitin-conjugating enzyme E2N (EC:6.3.2.19) |
C00002568
|
| 7381 | UQCRB, MC3DN3, QCR7, QP-C, QPC, UQBC, UQBP, UQCR6, UQPC | ubiquinol-cytochrome c reductase binding protein (EC:1.10.2.2) |
C00002568
|
| 7384 | UQCRC1, D3S3191, QCR1, UQCR1 | ubiquinol-cytochrome c reductase core protein I (EC:1.10.2.2) |
C00002568
|
| 7416 | VDAC1, PORIN, VDAC-1 | voltage-dependent anion channel 1 |
C00002568
|
| 7421 | VDR, NR1I1 | vitamin D (1,25- dihydroxyvitamin D3) receptor |
C00002568
|
| 7422 | VEGFA, MVCD1, VEGF, VPF | vascular endothelial growth factor A |
C00002568
|
| 7498 | XDH, XO, XOR | xanthine dehydrogenase (EC:1.17.1.4 1.17.3.2) |
C00002568
|
| 7529 | YWHAB, GW128, HS1, KCIP-1, YWHAA | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide |
C00002568
|
| 7532 | YWHAG, 14-3-3GAMMA | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide |
C00002568
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (98)
| OMIM | preferred title | UniProt |
|---|---|---|
| #100100 | Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism |
P20309
|
| #202300 | Adrenocortical carcinoma, hereditary; adcc |
P04637
|
| #103780 | Alcohol dependence |
P08172
P14416 P31645 |
| #612069 | Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 |
Q13148
|
| #614373 | Amyotrophic lateral sclerosis 16, juvenile; als16 |
Q99720
|
| #300068 | Androgen insensitivity syndrome; ais |
P10275
|
| #312300 | Androgen insensitivity, partial; pais |
P10275
|
| #608584 | Asthma-related traits, susceptibility to, 2 |
Q6W5P4
|
| #614740 | Basal cell carcinoma, susceptibility to, 7; bcc7 |
P04637
|
| #210900 | Bloom syndrome; blm |
P54132
|
| #602025 | Body mass index quantitative trait locus 9; bmiq9 |
P41968
|
| %606641 | Body mass index; bmi |
P37231
|
| #300615 | Brunner syndrome |
P21397
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #609338 | Carotid intimal medial thickness 1 |
P37231
|
| #118300 | Charcot-marie-tooth disease and deafness |
Q01453
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #118220 | Charcot-marie-tooth disease, demyelinating, type 1a; cmt1a |
Q01453
|
| #114500 | Colorectal cancer; crc |
P84022
|
| #162800 | Cyclic neutropenia |
P08246
|
| #612522 | Diabetes mellitus, insulin-dependent, 22; iddm22 |
P51681
|
| #119900 | Digital clubbing, isolated congenital |
P15428
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #237500 | Dubin-johnson syndrome; djs |
Q92887
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #133239 | Esophageal cancer |
P04637
|
| #615363 | Estrogen resistance; estrr |
P03372
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #613659 | Gastric cancer |
P04626
|
| #137215 | Gastric cancer, hereditary diffuse; hdgc |
P04626
|
| #231095 | Ghosal hematodiaphyseal dysplasia; ghdd |
P24557
|
| #137800 | Glioma susceptibility 1; glm1 |
P04626
P37231 |
| #139393 | Guillain-barre syndrome, familial; gbs |
Q01453
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #609423 | Human immunodeficiency virus type 1, susceptibility to |
P41597
P51681 |
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #145900 | Hypertrophic neuropathy of dejerine-sottas |
Q01453
|
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 |
P15428
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #603932 | Intervertebral disc disease; idd |
P14780
|
| #535000 | Leber optic atrophy |
P03905
|
| #500001 | Leber optic atrophy and dystonia |
P03905
|
| #151623 | Li-fraumeni syndrome 1; lfs1 |
P04637
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #604367 | Lipodystrophy, familial partial, type 3; fpld3 |
P37231
|
| #613795 | Loeys-dietz syndrome, type 3; lds3 |
P84022
|
| #613688 | Long qt syndrome 2; lqt2 |
Q12809
|
| #211980 | Lung cancer |
P00533
P04626 P04637 |
| #608516 | Major depressive disorder; mdd |
P08172
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| %300852 | Mental retardation, x-linked 88; mrx88 |
P50052
|
| #613073 | Metaphyseal anadysplasia 2; mandp2 |
P14780
|
| #540000 | Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes; melas |
P03905
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #126200 | Multiple sclerosis, susceptibility to; ms |
P08575
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #159900 | Myoclonic dystonia |
P14416
|
| #162500 | Neuropathy, hereditary, with liability to pressure palsies; hnpp |
Q01453
|
| #202700 | Neutropenia, severe congenital, 1, autosomal dominant; scn1 |
P08246
|
| #257220 | Niemann-pick disease, type c1; npc1 |
O15118
|
| #601665 | Obesity |
P32245
P37231 |
| #164230 | Obsessive-compulsive disorder; ocd |
P31645
|
| #604715 | Orthostatic intolerance |
P23975
|
| #259730 | Osteopetrosis, autosomal recessive 3; optb3 |
P00918
|
| #167000 | Ovarian cancer |
P04626
|
| #260500 | Papilloma of choroid plexus; cpp |
P04637
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #613135 | Parkinsonism-dystonia, infantile; pkdys |
Q01959
|
| #172700 | Pick disease of brain |
P10636
|
| #607276 | Resting heart rate, variation in |
P08588
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #604906 | Schizophrenia 9; sczd9 |
P49798
|
| #181500 | Schizophrenia; sczd |
P49798
|
| #608971 | Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive |
P08575
|
| #609620 | Short qt syndrome 1; sqt1 |
Q12809
|
| #313200 | Spinal and bulbar muscular atrophy, x-linked 1; smax1 |
P10275
|
| #253300 | Spinal muscular atrophy, type i; sma1 |
Q16637
|
| #253550 | Spinal muscular atrophy, type ii; sma2 |
Q16637
|
| #253400 | Spinal muscular atrophy, type iii; sma3 |
Q16637
|
| #271150 | Spinal muscular atrophy, type iv; sma4 |
Q16637
|
| #183090 | Spinocerebellar ataxia 2; sca2 |
Q99700
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
| #275355 | Squamous cell carcinoma, head and neck; hnscc |
P04637
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #187950 | Thrombocythemia 1; thcyt1 |
P40225
|
| #188570 | Thyroid hormone resistance, generalized, autosomal dominant; grth |
P10828
|
| #274300 | Thyroid hormone resistance, generalized, autosomal recessive; grth |
P10828
|
| #145650 | Thyroid hormone resistance, selective pituitary; prth |
P10828
|
| #190300 | Tremor, hereditary essential, 1; etm1 |
P35462
|
| #610379 | West nile virus, susceptibility to |
P51681
|
| #112100 | Yt blood group antigen |
P22303
|
KEGG DISEASE (92)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
P04637 (related) |
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00136 | Niemann-Pick disease type C (NPC) |
O15118
(related)
|
| H00016 | Oral cancer |
P00533
(related)
P00533 (marker) P04637 (related) P04637 (marker) |
| H00017 | Esophageal cancer |
P00533
(related)
P04637 (related) P04637 (marker) P35354 (related) |
| H00018 | Gastric cancer |
P00533
(related)
P04626 (related) P04637 (related) |
| H00022 | Bladder cancer |
P00533
(related)
P04626 (related) P04637 (related) |
| H00028 | Choriocarcinoma |
P00533
(related)
P03956 (related) P04626 (related) P04637 (related) |
| H00030 | Cervical cancer |
P00533
(related)
P04626 (related) |
| H00042 | Glioma |
P00533
(related)
P00533 (marker) P04637 (related) P04637 (marker) |
| H00055 | Laryngeal cancer |
P00533
(related)
P00533 (marker) P04637 (related) P04637 (marker) |
| H00241 | Combined proximal and distal renal tubular acidosis (RTA type 3) |
P00918
(related)
|
| H00436 | Osteopetrosis |
P00918
(related)
|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
Q01453 (related) |
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
P37231 (related) |
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00026 | Endometrial Cancer |
P03372
(marker)
P04626 (related) P04637 (related) Q92731 (marker) |
| H00068 | Leber optic atrophy |
P03905
(related)
|
| H00599 | 46,XX disorders of sex development (Disorders related to androgen excess) |
P04150
(related)
|
| H00019 | Pancreatic cancer |
P04626
(related)
P04637 (related) P04637 (marker) |
| H00027 | Ovarian cancer |
P04626
(related)
P04637 (related) |
| H00031 | Breast cancer |
P04626
(related)
P04626 (marker) P04637 (related) |
| H00046 | Cholangiocarcinoma |
P04626
(related)
P04637 (related) P35354 (related) |
| H00004 | Chronic myeloid leukemia (CML) |
P04637
(related)
|
| H00005 | Chronic lymphocytic leukemia (CLL) |
P04637
(related)
|
| H00006 | Hairy-cell leukemia |
P04637
(related)
|
| H00008 | Burkitt lymphoma |
P04637
(related)
|
| H00009 | Adult T-cell leukemia |
P04637
(related)
|
| H00010 | Multiple myeloma |
P04637
(related)
|
| H00013 | Small cell lung cancer |
P04637
(related)
|
| H00014 | Non-small cell lung cancer |
P04637
(related)
|
| H00015 | Malignant pleural mesothelioma |
P04637
(related)
|
| H00020 | Colorectal cancer |
P04637
(related)
P04637 (marker) |
| H00025 | Penile cancer |
P04637
(related)
P04637 (marker) P14780 (related) P35354 (related) |
| H00029 | Vulvar cancer |
P04637
(related)
|
| H00032 | Thyroid cancer |
P04637
(related)
P37231 (related) |
| H00036 | Osteosarcoma |
P04637
(related)
P08684 (marker) |
| H00038 | Malignant melanoma |
P04637
(related)
|
| H00039 | Basal cell carcinoma |
P04637
(related)
|
| H00040 | Squamous cell carcinoma |
P04637
(related)
|
| H00041 | Kaposi's sarcoma |
P04637
(related)
|
| H00044 | Cancer of the anal canal |
P04637
(related)
|
| H00047 | Gallbladder cancer |
P04637
(related)
|
| H00048 | Hepatocellular carcinoma |
P04637
(related)
|
| H00881 | Li-Fraumeni syndrome |
P04637
(related)
|
| H01007 | Choroid plexus papilloma |
P04637
(related)
|
| H00021 | Renal cell carcinoma |
P04637
(marker)
|
| H00093 | Combined immunodeficiencies (CIDs) |
P06239
(related)
|
| H00079 | Asthma |
P07550
(related)
|
| H00100 | Neutropenic disorders |
P08246
(related)
|
| H00091 | T-B+Severe combined immunodeficiencies (SCIDs) |
P08575
(related)
|
| H00024 | Prostate cancer |
P10275
(related)
|
| H00062 | Spinal and bulbar muscular atrophy (SBMA) |
P10275
(related)
|
| H00608 | 46,XY disorders of sex development (Disorders in androgen synthesis or action) |
P10275
(related)
|
| H00609 | 46,XY disorders of sex development (Other) |
P10275
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
Q13148 (related) |
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00249 | Thyroid hormone resistance syndrome |
P10828
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00479 | Metaphyseal dysplasias |
P14780
(related)
|
| H00457 | Primary hypertrophic osteoarthropathy (PHO) |
P15428
(related)
|
| H01246 | Isolated congenital nail clubbing (ICNC) |
P15428
(related)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P16473
(related)
|
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H00548 | Brunner syndrome |
P21397
(related)
|
| H01031 | Orthostatic intolerance (OI) |
P23975
(related)
|
| H00490 | Diaphyseal dysplasia with anemia (Ghosal) |
P24557
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00409 | Type II diabetes mellitus |
P37231
(related)
|
| H00227 | Congenital amegakaryocytic thrombocytopenia (CAMT) |
P40225
(marker)
|
| H00480 | Non-syndromic X-linked mental retardation |
P50052
(related)
|
| H00094 | DNA repair defects |
P54132
(related)
|
| H00296 | Defects in RecQ helicases |
P54132
(related)
|
| H01296 | Hereditary neuropathy with liability to pressure palsies (HNPP) |
Q01453
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q03164
(related)
Q03164 (marker) |
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00720 | Long QT syndrome |
Q12809
(related)
|
| H00725 | Short QT syndrome |
Q12809
(related)
|
| H00455 | Spinal muscular atrophy (SMA) |
Q16637
(related)
|
| H00208 | Hyperbilirubinemia |
Q92887
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q99700
(related)
Q9NUW8 (related) |
Diseases related to CTD interactions
42 disease in interactions with metabolites
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D001766 | Blindness |
C00002568
|
| D001862 | Bone Resorption |
C00002568
|
| D001930 | Brain Injuries |
C00002568
|
| D002375 | Catalepsy |
C00002568
|
| D002561 | Cerebrovascular Disorders |
C00002568
|
| D003643 | Death |
C00002568
|
| D004195 | Disease Models, Animal |
C00002568
|
| D056486 | Drug-Induced Liver Injury |
C00002568
|
| D020820 | Dyskinesias |
C00002568
|
| D004421 | Dystonia |
C00002568
|
| D005767 | Gastrointestinal Diseases |
C00002568
|
| D005911 | Gliosis |
C00002568
|
| D006470 | Hemorrhage |
C00002568
|
| D006930 | Hyperalgesia |
C00002568
|
| D018476 | Hypokinesia |
C00002568
|
| D007249 | Inflammation |
C00002568
|
| D020961 | Lewy Body Disease |
C00002568
|
| D028361 | Mitochondrial Diseases |
C00002568
|
| D016472 | Motor Neuron Disease |
C00002568
|
| D009069 | Movement Disorders |
C00002568
|
| D009127 | Muscle Rigidity |
C00002568
|
| D009336 | Necrosis |
C00002568
|
| D009410 | Nerve Degeneration |
C00002568
|
| D009437 | Neuralgia |
C00002568
|
| D019636 | Neurodegenerative Diseases |
C00002568
|
| D020879 | Neuromuscular Manifestations |
C00002568
|
| D020258 | Neurotoxicity Syndromes |
C00002568
|
| D029242 | Optic Atrophy, Hereditary, Leber |
C00002568
|
| D009901 | Optic Nerve Diseases |
C00002568
|
| D010190 | Pancreatic Neoplasms |
C00002568
|
| D010300 | Parkinson Disease |
C00002568
|
| D010302 | Parkinson Disease, Secondary |
C00002568
|
| D020734 | Parkinsonian Disorders |
C00002568
|
| D015427 | Reperfusion Injury |
C00002568
|
| D012162 | Retinal Degeneration |
C00002568
|
| D012798 | Sialorrhea |
C00002568
|
| D012818 | Signs and Symptoms, Respiratory |
C00002568
|
| D012893 | Sleep Disorders |
C00002568
|
| D020955 | Striatonigral Degeneration |
C00002568
|
| D024801 | Tauopathies |
C00002568
|
| D014786 | Vision Disorders |
C00002568
|
| D015431 | Weight Loss |
C00002568
|