PCIDB

KNApSAcK Metabolite C00029518

Metabolite

KNApSAcK Entry

id C00029518
Name 4',5,7-Trihydroxyflavanone / 5,7,4'-Trihydroxyflavanone
CAS RN 67604-48-2
Standard InChI InChI=1S/C15H12O5/c16-9-3-1-8(2-4-9)13-7-12(19)15-11(18)5-10(17)6-14(15)20-13/h1-6,13,16-18H,7H2
Standard InChI (Main Layer) InChI=1S/C15H12O5/c16-9-3-1-8(2-4-9)13-7-12(19)15-11(18)5-10(17)6-14(15)20-13/h1-6,13,16-18H,7H2

Cluster

Phytochemical cluster No. 14
KCF-S cluster No. 25

Link

ChEMBL

By standard InChI CHEMBL32571
By standard InChI Main Layer CHEMBL9352 CHEMBL32571

KEGG

By LinkDB

CTD

By CAS RN

Human Protein / Gene in interaction

57 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 CHEMBL9352 CHEMBL1741321 (1)
1 / 0
P14061 Estradiol 17-beta-dehydrogenase 1 Enzyme CHEMBL9352 CHEMBL957998 (1) CHEMBL957999 (1)
0 / 0
P33527 Multidrug resistance-associated protein 1 drugs CHEMBL9352 CHEMBL1062294 (1) CHEMBL2076527 (1)
0 / 0
P22310 UDP-glucuronosyltransferase 1-4 Enzyme CHEMBL9352 CHEMBL1908081 (1) CHEMBL1908082 (1)
3 / 0
P18031 Tyrosine-protein phosphatase non-receptor type 1 Tyr CHEMBL9352 CHEMBL995832 (1)
0 / 0
Q9Y6L6 Solute carrier organic anion transporter family member 1B1 Electrochemical transporter CHEMBL9352 CHEMBL2169429 (1)
1 / 0
O94956 Solute carrier organic anion transporter family member 2B1 Unclassified protein CHEMBL9352 CHEMBL2076048 (1) CHEMBL2076049 (1)
CHEMBL2169431 (1)
0 / 0
Q9HAW8 UDP-glucuronosyltransferase 1-10 Enzyme CHEMBL9352 CHEMBL1908087 (1)
0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase CHEMBL9352 CHEMBL1014033 (1) CHEMBL1008495 (1)
0 / 3
P04062 Glucosylceramidase Enzyme CHEMBL32571 CHEMBL1613818 (2)
6 / 4
Q03181 Peroxisome proliferator-activated receptor delta NR1C2 CHEMBL9352 CHEMBL2341203 (1) CHEMBL2341207 (1)
0 / 0
P62158 Calmodulin Unclassified protein CHEMBL9352 CHEMBL1647727 (2) CHEMBL1647728 (1)
1 / 0
P47989 Xanthine dehydrogenase/oxidase Oxidoreductase CHEMBL9352 CHEMBL1023248 (1)
1 / 1
P04798 Cytochrome P450 1A1 Cytochrome P450 1A1 CHEMBL9352 CHEMBL1225717 (1)
0 / 0
P08183 Multidrug resistance protein 1 drug CHEMBL9352 CHEMBL2075378 (1) CHEMBL2077302 (1)
CHEMBL2075425 (1) CHEMBL2078579 (1)
1 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 CHEMBL9352 CHEMBL1614027 (1) CHEMBL1741325 (1)
0 / 1
P24941 Cyclin-dependent kinase 2 Cdc2 CHEMBL32571 CHEMBL2318159 (1)
0 / 0
P24864 G1/S-specific cyclin-E1 Other cytosolic protein CHEMBL32571 CHEMBL2318159 (1)
0 / 2
O75828 Carbonyl reductase [NADPH] 3 Enzyme CHEMBL9352 CHEMBL1004501 (1) CHEMBL1004502 (1)
CHEMBL1004503 (1)
0 / 0
P41145 Kappa-type opioid receptor Opioid receptor CHEMBL9352 CHEMBL926465 (1)
0 / 0
P04278 Sex hormone-binding globulin Secreted protein CHEMBL9352 CHEMBL922711 (2)
0 / 0
P36888 Receptor-type tyrosine-protein kinase FLT3 Pdgfr CHEMBL9352 CHEMBL2342404 (1)
1 / 1
P16152 Carbonyl reductase [NADPH] 1 Enzyme CHEMBL9352 CHEMBL1004498 (1) CHEMBL1004499 (1)
CHEMBL1004500 (1) CHEMBL1004504 (1)
CHEMBL1004505 (2)
0 / 0
O75496 Geminin Unclassified protein CHEMBL9352 CHEMBL32571 CHEMBL2114843 (1) CHEMBL2114780 (1)
0 / 0
P54855 UDP-glucuronosyltransferase 2B15 Enzyme CHEMBL9352 CHEMBL1908090 (1)
0 / 0
P41143 Delta-type opioid receptor Opioid receptor CHEMBL9352 CHEMBL926467 (1)
0 / 0
Q92731 Estrogen receptor beta NR3A2 CHEMBL9352 CHEMBL909844 (1) CHEMBL909845 (1)
0 / 1
P15121 Aldose reductase Enzyme CHEMBL9352 CHEMBL1942674 (1)
0 / 0
Q9NPD5 Solute carrier organic anion transporter family member 1B3 Electrochemical transporter CHEMBL9352 CHEMBL2169430 (1)
1 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme CHEMBL9352 CHEMBL1794467 (1)
0 / 0
P04150 Glucocorticoid receptor NR3C1 CHEMBL9352 CHEMBL1052489 (1) CHEMBL1052500 (1)
0 / 1
P11511 Cytochrome P450 19A1 Cytochrome P450 19A1 CHEMBL9352 CHEMBL949646 (1) CHEMBL1105634 (1)
CHEMBL1918238 (1) CHEMBL1941245 (1)
CHEMBL2213354 (1)
2 / 2
P37231 Peroxisome proliferator-activated receptor gamma NR1C3 CHEMBL9352 CHEMBL1059360 (1) CHEMBL1059361 (1)
5 / 3
Q16678 Cytochrome P450 1B1 Cytochrome P450 1B1 CHEMBL9352 CHEMBL1225718 (1)
4 / 4
P04745 Alpha-amylase 1 Enzyme CHEMBL9352 CHEMBL964479 (2)
0 / 0
P18054 Arachidonate 12-lipoxygenase, 12S-type Enzyme CHEMBL32571 CHEMBL1614252 (1)
2 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 CHEMBL9352 CHEMBL1225716 (1) CHEMBL1741322 (1)
0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme CHEMBL9352 CHEMBL1614227 (1)
3 / 3
Q9UNQ0 ATP-binding cassette sub-family G member 2 ATP binding cassette CHEMBL9352 CHEMBL2076473 (1) CHEMBL2076243 (1)
CHEMBL2076820 (1) CHEMBL2076835 (1)
CHEMBL2078552 (1)
2 / 0
Q92887 Canalicular multispecific organic anion transporter 1 Unclassified protein CHEMBL9352 CHEMBL1006005 (1)
1 / 1
Q9HAW9 UDP-glucuronosyltransferase 1-8 Enzyme CHEMBL9352 CHEMBL1908085 (2)
0 / 0
O76074 cGMP-specific 3',5'-cyclic phosphodiesterase PDE_5A CHEMBL9352 CHEMBL998835 (1)
0 / 0
P03372 Estrogen receptor NR3A1 CHEMBL9352 CHEMBL909843 (1) CHEMBL909845 (1)
1 / 1
P22303 Acetylcholinesterase Hydrolase CHEMBL9352 CHEMBL2014392 (1) CHEMBL2014393 (1)
1 / 0
P35372 Mu-type opioid receptor Opioid receptor CHEMBL9352 CHEMBL926466 (1)
0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 CHEMBL9352 CHEMBL1613777 (2) CHEMBL1741323 (1)
1 / 1
P37059 Estradiol 17-beta-dehydrogenase 2 Enzyme CHEMBL9352 CHEMBL958788 (1) CHEMBL958789 (1)
0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 CHEMBL9352 CHEMBL32571 CHEMBL1614108 (3) CHEMBL1613886 (3)
CHEMBL1741324 (1)
0 / 1
Q9UNA4 DNA polymerase iota Enzyme CHEMBL32571 CHEMBL1794483 (1)
0 / 0
P22309 UDP-glucuronosyltransferase 1-1 Enzyme CHEMBL9352 CHEMBL1908080 (2)
5 / 1
P10275 Androgen receptor NR3C4 CHEMBL9352 CHEMBL1052499 (1)
3 / 4
Q07869 Peroxisome proliferator-activated receptor alpha NR1C1 CHEMBL9352 CHEMBL1059364 (1) CHEMBL1059365 (1)
0 / 0
Q04760 Lactoylglutathione lyase Enzyme CHEMBL9352 CHEMBL684310 (1) CHEMBL967535 (1)
0 / 0
P49888 Estrogen sulfotransferase Enzyme CHEMBL9352 CHEMBL1743309 (1)
0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme CHEMBL9352 CHEMBL1614364 (1)
1 / 1
O00255 Menin Unclassified protein CHEMBL32571 CHEMBL1614257 (2)
2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme CHEMBL32571 CHEMBL1614257 (2)
1 / 3

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (46)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#300068 Androgen insensitivity syndrome; ais P10275
#312300 Androgen insensitivity, partial; pais P10275
#613546 Aromatase deficiency P11511
#139300 Aromatase excess syndrome; aexs P11511
#601816 Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 P22309
#614490 Blood group, junior system; jr Q9UNQ0
%606641 Body mass index; bmi P37231
#609338 Carotid intimal medial thickness 1 P37231
#114500 Colorectal cancer; crc P18054
#218800 Crigler-najjar syndrome, type i P22309
P22310
#606785 Crigler-najjar syndrome, type ii P22309
P22310
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#237500 Dubin-johnson syndrome; djs Q92887
#133239 Esophageal cancer P18054
#615363 Estrogen resistance; estrr P03372
#608013 Gaucher disease, perinatal lethal P04062
#230800 Gaucher disease, type i P04062
#230900 Gaucher disease, type ii P04062
#231000 Gaucher disease, type iii P04062
#231005 Gaucher disease, type iiic P04062
#143500 Gilbert syndrome P22309
P22310
#137750 Glaucoma 1, open angle, a; glc1a Q16678
#231300 Glaucoma 3, primary congenital, a; glc3a Q16678
#137760 Glaucoma, primary open angle; poag Q16678
#137800 Glioma susceptibility 1; glm1 P37231
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#237450 Hyperbilirubinemia, rotor type; hblrr Q9NPD5
Q9Y6L6
#237900 Hyperbilirubinemia, transient familial neonatal; hblrtfn P22309
#145000 Hyperparathyroidism 1; hrpt1 O00255
#612244 Inflammatory bowel disease 13; ibd13 P08183
#601626 Leukemia, acute myeloid; aml P36888
#604367 Lipodystrophy, familial partial, type 3; fpld3 P37231
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#601665 Obesity P37231
#168600 Parkinson disease, late-onset; pd P04062
#604229 Peters anomaly Q16678
#313200 Spinal and bulbar muscular atrophy, x-linked 1; smax1 P10275
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#138900 Uric acid concentration, serum, quantitative trait locus 1; uaqtl1 Q9UNQ0
#614916 Ventricular tachycardia, catecholaminergic polymorphic, 4; cpvt4 P62158
#278300 Xanthinuria, type i P47989
#112100 Yt blood group antigen P22303

KEGG DISEASE (40)

KEGG disease name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00026 Endometrial Cancer P03372 (marker)
Q92731 (marker)
H00066 Lewy body dementia (LBD) P04062 (related)
H00126 Gaucher disease P04062 (related)
H00426 Defects in the degradation of ganglioside P04062 (related)
H00810 Progressive myoclonic epilepsy (PME) P04062 (related)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
P11511 (related)
H00036 Osteosarcoma P08684 (marker)
H00024 Prostate cancer P10275 (related)
H00062 Spinal and bulbar muscular atrophy (SBMA) P10275 (related)
H00608 46,XY disorders of sex development (Disorders in androgen synthesis or action) P10275 (related)
H00609 46,XY disorders of sex development (Other) P10275 (related)
H00794 Aromatase excess syndrome P11511 (related)
H01205 Coumarin resistance P11712 (related)
H00208 Hyperbilirubinemia P22309 (related)
Q92887 (related)
H00018 Gastric cancer P24864 (related)
H00055 Laryngeal cancer P24864 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00017 Esophageal cancer P35354 (related)
H00025 Penile cancer P35354 (related)
H00046 Cholangiocarcinoma P35354 (related)
H00003 Acute myeloid leukemia (AML) P36888 (related)
H00032 Thyroid cancer P37231 (related)
H00409 Type II diabetes mellitus P37231 (related)
H00420 Familial partial lipodystrophy (FPL) P37231 (related)
H00192 Xanthinuria P47989 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00612 Primary open angle glaucoma Q16678 (related)
H01075 Peters anomaly Q16678 (related)
H01159 Anterior segment dysgenesis (ASD) Q16678 (related)
H01203 Primary congenital glaucoma (PCG) Q16678 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H00063 Spinocerebellar ataxia (SCA) Q9NUW8 (related)