PCIDB

KNApSAcK Metabolite C00008126

Metabolite

KNApSAcK Entry

id C00008126
Name 7-Hydroxyflavanone
CAS RN 6515-36-2
Standard InChI InChI=1S/C15H12O3/c16-11-6-7-12-13(17)9-14(18-15(12)8-11)10-4-2-1-3-5-10/h1-8,14,16H,9H2
Standard InChI (Main Layer) InChI=1S/C15H12O3/c16-11-6-7-12-13(17)9-14(18-15(12)8-11)10-4-2-1-3-5-10/h1-8,14,16H,9H2

Cluster

Phytochemical cluster No. 14
KCF-S cluster No. 25

Link

ChEMBL

By standard InChI CHEMBL97542
By standard InChI Main Layer CHEMBL97542 CHEMBL402744

KEGG

By LinkDB C14290

CTD

By CAS RN C059353

Human Protein / Gene in interaction

9 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P04637 Cellular tumor antigen p53 Transcription Factor CHEMBL97542 CHEMBL1738132 (1)
7 / 44
P05091 Aldehyde dehydrogenase, mitochondrial Oxidoreductase CHEMBL97542 CHEMBL641142 (1)
1 / 1
P38398 Breast cancer type 1 susceptibility protein Enzyme CHEMBL97542 CHEMBL2114807 (1)
4 / 2
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor CHEMBL97542 CHEMBL2114788 (1)
0 / 0
P04150 Glucocorticoid receptor NR3C1 CHEMBL97542 CHEMBL1052489 (1) CHEMBL1052500 (1)
0 / 1
P11511 Cytochrome P450 19A1 Cytochrome P450 19A1 CHEMBL97542 CHEMBL649354 (1) CHEMBL932215 (1)
CHEMBL932216 (1)
2 / 2
P10275 Androgen receptor NR3C4 CHEMBL97542 CHEMBL1052499 (1)
3 / 4
P27338 Amine oxidase [flavin-containing] B Oxidoreductase CHEMBL97542 CHEMBL731145 (1)
0 / 0
P21397 Amine oxidase [flavin-containing] A Oxidoreductase CHEMBL97542 CHEMBL731145 (1)
1 / 1

CTD interaction (1)

compound gene gene name gene description interaction interaction type form reference
pmid
C059353 1588 CYP19A1
ARO
ARO1
CPV1
CYAR
CYP19
CYPXIX
P-450AROM
cytochrome P450, family 19, subfamily A, polypeptide 1 (EC:1.14.14.1) 7-hydroxyflavanone results in decreased activity of CYP19A1 protein decreases activity
protein 15319488

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (18)

OMIM preferred title UniProt
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#610251 Alcohol sensitivity, acute P05091
#300068 Androgen insensitivity syndrome; ais P10275
#312300 Androgen insensitivity, partial; pais P10275
#613546 Aromatase deficiency P11511
#139300 Aromatase excess syndrome; aexs P11511
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#114480 Breast cancer P38398
#604370 Breast-ovarian cancer, familial, susceptibility to, 1; brovca1 P38398
#300615 Brunner syndrome P21397
#133239 Esophageal cancer P04637
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#211980 Lung cancer P04637
#167000 Ovarian cancer P38398
#614320 Pancreatic cancer, susceptibility to, 4; pnca4 P38398
#260500 Papilloma of choroid plexus; cpp P04637
#313200 Spinal and bulbar muscular atrophy, x-linked 1; smax1 P10275
#275355 Squamous cell carcinoma, head and neck; hnscc P04637

KEGG DISEASE (45)

KEGG disease name UniProt
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
P11511 (related)
H00004 Chronic myeloid leukemia (CML) P04637 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00016 Oral cancer P04637 (related)
P04637 (marker)
H00017 Esophageal cancer P04637 (related)
P04637 (marker)
H00018 Gastric cancer P04637 (related)
H00019 Pancreatic cancer P04637 (related)
P04637 (marker)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
H00022 Bladder cancer P04637 (related)
H00025 Penile cancer P04637 (related)
P04637 (marker)
H00026 Endometrial Cancer P04637 (related)
H00027 Ovarian cancer P04637 (related)
P38398 (related)
H00028 Choriocarcinoma P04637 (related)
H00029 Vulvar cancer P04637 (related)
H00031 Breast cancer P04637 (related)
P38398 (related)
H00032 Thyroid cancer P04637 (related)
H00033 Adrenal carcinoma P04637 (related)
H00036 Osteosarcoma P04637 (related)
H00038 Malignant melanoma P04637 (related)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00042 Glioma P04637 (related)
P04637 (marker)
H00044 Cancer of the anal canal P04637 (related)
H00046 Cholangiocarcinoma P04637 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00055 Laryngeal cancer P04637 (related)
P04637 (marker)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00021 Renal cell carcinoma P04637 (marker)
H01071 Acute alcohol sensitivity P05091 (related)
H00024 Prostate cancer P10275 (related)
H00062 Spinal and bulbar muscular atrophy (SBMA) P10275 (related)
H00608 46,XY disorders of sex development (Disorders in androgen synthesis or action) P10275 (related)
H00609 46,XY disorders of sex development (Other) P10275 (related)
H00794 Aromatase excess syndrome P11511 (related)
H00548 Brunner syndrome P21397 (related)