Heracleum candicans WALL.
Species
KNApSAcK Entry
| Organism name | Heracleum candicans WALL. |
|---|---|
| Genus | Heracleum |
| Family | Apiaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Heracleum |
|---|---|
| Linked NCBI taxonomy ID | 40917 |
| Linked level | genus |
Family
| Family in NCBI taxonomy | Apiaceae |
|---|---|
| ID | 4037 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | asterids |
|---|---|
| ID | 71274 |
Metabolite list (21)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00029680
|
Ammajin
/ Marmesinin / (-)-Marmesinin |
CHEMBL459825
|
11 / 8 / 6 | No. 399 | No. 25 |
|
||
|
C00002488
|
Osthol
/ Osthole |
CHEMBL52229
|
C046627
|
12 / 6 / 5 | 7 / 4 | No. 466 | No. 25 |
|
|
C00029597
|
8-(3-Chloro-2-hydroxy-3-methylbutoxy)psoralen
/ (+)-8-(3-Chloro-2-hydroxy-3-methylbutoxy)psoralen |
No. 579 | No. 25 |
|
||||
|
C00030531
|
Isogosferol
/ Isogospherol / (+)-Isogospherol |
No. 606 | No. 25 |
|
||||
|
C00002493
|
Pimpinellin
|
CHEMBL1491809
|
C039409
|
3 / 0 / 1 | No. 606 | No. 25 |
|
|
|
C00031177
|
Rivulobirin C
|
No. 692 |
|
|||||
|
C00031178
|
Rivulobirin D
/ (-)-Rivulobirin D |
No. 692 |
|
|||||
|
C00029608
|
9,17-Octadecadiene-12,14-diyne-1,11,16-triol
|
No. 940 | No. 69 |
|
||||
|
C00001283
|
Falcarindiol
|
CHEMBL69018
CHEMBL1094112 |
C034379
|
3 / 0 / 0 | No. 940 | No. 69 |
|
|
|
C00002503
|
Umbelliferon
/ Umbelliferone / 7-Hydroxycoumarin |
CHEMBL51628
|
C031477
|
39 / 33 / 32 | 9 / 0 | No. 1030 | No. 25 |
|
|
C00000584
|
(+)-Marmesin
|
CHEMBL442813
CHEMBL1464240 |
C001684
|
12 / 24 / 49 | No. 1336 | No. 25 |
|
|
|
C00029297
|
Columbianetin
/ (+)-Columbianetin |
CHEMBL201152
|
7 / 12 / 8 | No. 1336 | No. 25 |
|
||
|
C00029602
|
8-Geranyl-5-methoxypsoralen
/ 8-Geranyloxy-5-methoxypsoralen |
CHEMBL1934197
|
1 / 0 / 0 | No. 1664 |
|
|||
|
C00030973
|
Peucedanol
|
No. 1726 |
|
|||||
|
C00029304
|
(+)-Meranzin hydrate
|
CHEMBL433093
|
2 / 0 / 0 | No. 1726 |
|
|||
|
C00030900
|
Osthenol
|
CHEMBL350475
|
C114745
|
2 / 0 / 0 | No. 2087 |
|
||
|
C00031176
|
Rivulobirin A
|
CHEMBL1731549
|
3 / 1 / 1 | No. 2316 |
|
|||
|
C00031179
|
Rivulobirin E
|
No. 2316 |
|
|||||
|
C00031181
|
Rivulotririn B
|
No. 5571 |
|
|||||
|
C00031180
|
Rivulotririn A
|
No. 5571 |
|
|||||
|
C00031079
|
Prandiol
/ Protangix |
CHEMBL932
|
D004176
|
174 / 113 / 83 | 33 / 77 | No. 8896 |
|
Human Protein / Gene in interactions
209 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00002488 C00002493 C00002503 C00029297 C00029680 C00031079 | 0 / 0 |
| P56817 | Beta-secretase 1 | A1A | C00000584 C00002488 C00002503 C00029297 C00029602 C00030900 | 0 / 0 |
| O75496 | Geminin | Unclassified protein | C00002488 C00002503 C00029680 C00031079 C00031176 | 0 / 0 |
| P17405 | Sphingomyelin phosphodiesterase | Enzyme | C00000584 C00029297 C00029680 C00031079 | 2 / 2 |
| P23219 | Prostaglandin G/H synthase 1 | Oxidoreductase | C00001283 C00002488 C00030900 C00031079 | 0 / 0 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00002503 C00029297 C00029304 C00031079 | 0 / 0 |
| P10253 | Lysosomal alpha-glucosidase | Hydrolase | C00002503 C00029297 C00029680 C00031079 | 1 / 1 |
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | C00002503 C00029297 C00029680 C00031079 | 2 / 2 |
| P22303 | Acetylcholinesterase | Hydrolase | C00000584 C00002503 C00029680 C00031079 | 1 / 0 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00000584 C00031079 C00031176 | 0 / 0 |
| Q99700 | Ataxin-2 | Unclassified protein | C00002503 C00031079 C00031176 | 1 / 1 |
| P04062 | Glucosylceramidase | Enzyme | C00000584 C00002488 C00002503 | 6 / 4 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00002488 C00002493 C00031079 | 0 / 1 |
| Q9NR56 | Muscleblind-like protein 1 | Unclassified protein | C00000584 C00029680 C00031079 | 1 / 0 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00002488 C00002503 C00029304 | 0 / 0 |
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | C00002488 C00031079 | 0 / 0 |
| P35354 | Prostaglandin G/H synthase 2 | Oxidoreductase | C00002503 C00031079 | 0 / 3 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00002503 C00031079 | 1 / 2 |
| P38398 | Breast cancer type 1 susceptibility protein | Enzyme | C00000584 C00031079 | 4 / 2 |
| P06280 | Alpha-galactosidase A | Enzyme | C00002503 C00029680 | 1 / 1 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | C00002503 C00031079 | 3 / 3 |
| P55210 | Caspase-7 | C14 | C00002503 C00031079 | 0 / 0 |
| P29466 | Caspase-1 | C14 | C00002503 C00031079 | 0 / 0 |
| Q92830 | Histone acetyltransferase KAT2A | Enzyme | C00002503 C00031079 | 0 / 0 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00000584 C00029680 | 0 / 0 |
| P04406 | Glyceraldehyde-3-phosphate dehydrogenase | Enzyme | C00002488 C00002503 | 0 / 0 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00029680 C00031079 | 0 / 0 |
| P41145 | Kappa-type opioid receptor | Opioid receptor | C00001283 C00031079 | 0 / 0 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00002503 C00031079 | 1 / 1 |
| O00255 | Menin | Unclassified protein | C00002503 C00031079 | 2 / 5 |
| P00918 | Carbonic anhydrase 2 | Lyase | C00002503 C00031079 | 1 / 2 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00031079 | 1 / 0 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | C00031079 | 3 / 2 |
| P47989 | Xanthine dehydrogenase/oxidase | Oxidoreductase | C00002503 | 1 / 1 |
| Q99808 | Equilibrative nucleoside transporter 1 | Nucleoside uniporter | C00031079 | 0 / 0 |
| P10828 | Thyroid hormone receptor beta | NR1A2 | C00031079 | 3 / 1 |
| O75604 | Ubiquitin carboxyl-terminal hydrolase 2 | Enzyme | C00031079 | 0 / 0 |
| P07550 | Beta-2 adrenergic receptor | Adrenergic receptor | C00031079 | 0 / 1 |
| P21397 | Amine oxidase [flavin-containing] A | Oxidoreductase | C00031079 | 1 / 1 |
| P25021 | Histamine H2 receptor | Histamine receptor | C00031079 | 0 / 0 |
| P35367 | Histamine H1 receptor | Histamine receptor | C00031079 | 0 / 0 |
| Q01959 | Sodium-dependent dopamine transporter | Dopamine | C00031079 | 1 / 0 |
| P08912 | Muscarinic acetylcholine receptor M5 | Acetylcholine receptor | C00031079 | 0 / 0 |
| P18825 | Alpha-2C adrenergic receptor | Adrenergic receptor | C00031079 | 0 / 0 |
| P13945 | Beta-3 adrenergic receptor | Adrenergic receptor | C00031079 | 0 / 0 |
| P34969 | 5-hydroxytryptamine receptor 7 | Serotonin receptor | C00001283 | 0 / 0 |
| P08183 | Multidrug resistance protein 1 | drug | C00031079 | 1 / 0 |
| P25024 | C-X-C chemokine receptor type 1 | CXC chemokine receptor | C00031079 | 0 / 0 |
| P06241 | Tyrosine-protein kinase Fyn | Src | C00031079 | 0 / 0 |
| Q08209 | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform | Ser_Thr | C00031079 | 0 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00031079 | 0 / 1 |
| O95263 | High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B | PDE_8B | C00031079 | 2 / 1 |
| P54132 | Bloom syndrome protein | Enzyme | C00031079 | 1 / 2 |
| O15245 | Solute carrier family 22 member 1 | Drug uniporter | C00031079 | 0 / 0 |
| P00533 | Epidermal growth factor receptor | TK tyrosine-protein kinase EGFR subfamily | C00031079 | 1 / 8 |
| P14416 | D(2) dopamine receptor | Dopamine receptor | C00031079 | 2 / 0 |
| Q13315 | Serine-protein kinase ATM | Atypical serine/threonine protein kinase PIKK subfamily | C00031079 | 1 / 4 |
| P37288 | Vasopressin V1a receptor | Vasopressin and oxytocin receptor | C00031079 | 0 / 0 |
| Q13526 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Enzyme | C00031079 | 0 / 0 |
| Q9Y271 | Cysteinyl leukotriene receptor 1 | Leukotriene receptor | C00031079 | 0 / 0 |
| P29274 | Adenosine receptor A2a | Adenosine receptor | C00031079 | 0 / 0 |
| P25929 | Neuropeptide Y receptor type 1 | Neuropeptide Y receptor | C00031079 | 0 / 0 |
| P50052 | Type-2 angiotensin II receptor | Angiotensin receptor | C00031079 | 1 / 1 |
| O15296 | Arachidonate 15-lipoxygenase B | Enzyme | C00031079 | 0 / 0 |
| P17948 | Vascular endothelial growth factor receptor 1 | Vegfr | C00031079 | 0 / 0 |
| P41968 | Melanocortin receptor 3 | Melanocortin receptor | C00031079 | 1 / 0 |
| P14780 | Matrix metalloproteinase-9 | M10A | C00031079 | 2 / 2 |
| P28845 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Enzyme | C00002503 | 1 / 1 |
| P27361 | Mitogen-activated protein kinase 3 | Erk | C00031079 | 0 / 0 |
| O43570 | Carbonic anhydrase 12 | Lyase | C00002503 | 1 / 2 |
| P11509 | Cytochrome P450 2A6 | Cytochrome P450 2A6 | C00031079 | 0 / 0 |
| Q16665 | Hypoxia-inducible factor 1-alpha | Transcription Factor | C00031079 | 0 / 0 |
| O60658 | High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A | PDE_8A | C00031079 | 0 / 0 |
| P39748 | Flap endonuclease 1 | Enzyme | C00002503 | 0 / 0 |
| P17252 | Protein kinase C alpha type | Alpha | C00031079 | 0 / 0 |
| P84022 | Mothers against decapentaplegic homolog 3 | Unclassified protein | C00031079 | 2 / 0 |
| P49146 | Neuropeptide Y receptor type 2 | Neuropeptide Y receptor | C00031079 | 0 / 0 |
| O15439 | Multidrug resistance-associated protein 4 | Unclassified protein | C00031079 | 0 / 0 |
| Q16539 | Mitogen-activated protein kinase 14 | p38 | C00031079 | 0 / 0 |
| P54855 | UDP-glucuronosyltransferase 2B15 | Enzyme | C00002503 | 0 / 0 |
| P04035 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | Oxidoreductase | C00031079 | 0 / 0 |
| P08913 | Alpha-2A adrenergic receptor | Adrenergic receptor | C00031079 | 0 / 0 |
| P18405 | 3-oxo-5-alpha-steroid 4-dehydrogenase 1 | Oxidoreductase | C00002503 | 0 / 0 |
| P21917 | D(4) dopamine receptor | Dopamine receptor | C00031079 | 0 / 0 |
| P30988 | Calcitonin receptor | Calcitonin receptor | C00031079 | 0 / 0 |
| P35462 | D(3) dopamine receptor | Dopamine receptor | C00031079 | 1 / 0 |
| P41143 | Delta-type opioid receptor | Opioid receptor | C00031079 | 0 / 0 |
| Q92731 | Estrogen receptor beta | NR3A2 | C00031079 | 0 / 1 |
| P41595 | 5-hydroxytryptamine receptor 2B | Serotonin receptor | C00031079 | 0 / 0 |
| P15121 | Aldose reductase | Enzyme | C00002503 | 0 / 0 |
| P25101 | Endothelin-1 receptor | Endothelin receptor | C00031079 | 0 / 0 |
| P30411 | B2 bradykinin receptor | Bradykinin receptor | C00031079 | 0 / 0 |
| P32245 | Melanocortin receptor 4 | Melanocortin receptor | C00031079 | 1 / 0 |
| P00915 | Carbonic anhydrase 1 | Lyase | C00002503 | 0 / 0 |
| P32238 | Cholecystokinin receptor type A | Cholecystokinin receptor | C00031079 | 0 / 0 |
| P08311 | Cathepsin G | S1A | C00031079 | 0 / 0 |
| Q99720 | Sigma non-opioid intracellular receptor 1 | Membrane receptor | C00031079 | 1 / 0 |
| P43220 | Glucagon-like peptide 1 receptor | Glucagon-like peptide receptor | C00002488 | 0 / 0 |
| P03956 | Interstitial collagenase | M10A | C00031079 | 0 / 1 |
| P32241 | Vasoactive intestinal polypeptide receptor 1 | Vasoactive intestinal peptide receptor | C00031079 | 0 / 0 |
| P63092 | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | Other membrane protein | C00029297 | 7 / 3 |
| Q9Y233 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | PDE_10A | C00031079 | 0 / 0 |
| Q9Y468 | Lethal(3)malignant brain tumor-like protein 1 | Unclassified protein | C00029680 | 0 / 0 |
| P33765 | Adenosine receptor A3 | Adenosine receptor | C00031079 | 0 / 0 |
| P08246 | Neutrophil elastase | S1A | C00031079 | 2 / 1 |
| Q9NPD5 | Solute carrier organic anion transporter family member 1B3 | Electrochemical transporter | C00031079 | 1 / 0 |
| Q12809 | Potassium voltage-gated channel subfamily H member 2 | KCNH, Kv10-12.x (Ether-a-go-go) | C00031079 | 2 / 2 |
| Q99816 | Tumor susceptibility gene 101 protein | Unclassified protein | C00031079 | 0 / 0 |
| P04150 | Glucocorticoid receptor | NR3C1 | C00031079 | 0 / 1 |
| P08172 | Muscarinic acetylcholine receptor M2 | Acetylcholine receptor | C00031079 | 2 / 0 |
| P11229 | Muscarinic acetylcholine receptor M1 | Acetylcholine receptor | C00031079 | 0 / 0 |
| P11511 | Cytochrome P450 19A1 | Cytochrome P450 19A1 | C00000584 | 2 / 2 |
| P14679 | Tyrosinase | Oxidoreductase | C00002503 | 4 / 2 |
| P21554 | Cannabinoid receptor 1 | Cannabinoid receptor | C00031079 | 0 / 0 |
| P31645 | Sodium-dependent serotonin transporter | Serotonin | C00031079 | 2 / 0 |
| P04626 | Receptor tyrosine-protein kinase erbB-2 | TK tyrosine-protein kinase EGFR subfamily | C00031079 | 5 / 9 |
| P20309 | Muscarinic acetylcholine receptor M3 | Acetylcholine receptor | C00031079 | 1 / 0 |
| P21452 | Substance-K receptor | Neurokinin receptor | C00031079 | 0 / 0 |
| P51679 | C-C chemokine receptor type 4 | CC chemokine receptor | C00031079 | 0 / 0 |
| P51681 | C-C chemokine receptor type 5 | CC chemokine receptor | C00031079 | 3 / 0 |
| P50406 | 5-hydroxytryptamine receptor 6 | Serotonin receptor | C00031079 | 0 / 0 |
| P21728 | D(1A) dopamine receptor | Dopamine receptor | C00031079 | 0 / 0 |
| P41597 | C-C chemokine receptor type 2 | CC chemokine receptor | C00031079 | 1 / 0 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00031079 | 0 / 0 |
| P08575 | Receptor-type tyrosine-protein phosphatase C | Enzyme | C00031079 | 2 / 1 |
| P09917 | Arachidonate 5-lipoxygenase | Oxidoreductase | C00002488 | 0 / 0 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00031079 | 0 / 0 |
| Q16790 | Carbonic anhydrase 9 | Lyase | C00002503 | 0 / 1 |
| P49798 | Regulator of G-protein signaling 4 | Unclassified protein | C00031079 | 2 / 0 |
| Q92887 | Canalicular multispecific organic anion transporter 1 | Unclassified protein | C00031079 | 1 / 1 |
| Q9HAW8 | UDP-glucuronosyltransferase 1-10 | Enzyme | C00002503 | 0 / 0 |
| O15118 | Niemann-Pick C1 protein | Unclassified protein | C00000584 | 1 / 1 |
| Q01453 | Peripheral myelin protein 22 | Unclassified protein | C00031079 | 5 / 2 |
| Q96FL8 | Multidrug and toxin extrusion protein 1 | Cation antiporter | C00031079 | 0 / 0 |
| Q86VL8 | Multidrug and toxin extrusion protein 2 | Cation antiporter | C00031079 | 0 / 0 |
| Q9HAW9 | UDP-glucuronosyltransferase 1-8 | Enzyme | C00002503 | 0 / 0 |
| Q9Y4X1 | UDP-glucuronosyltransferase 2A1 | Enzyme | C00002503 | 0 / 0 |
| O76074 | cGMP-specific 3',5'-cyclic phosphodiesterase | PDE_5A | C00031079 | 0 / 0 |
| P03372 | Estrogen receptor | NR3A1 | C00031079 | 1 / 1 |
| P08588 | Beta-1 adrenergic receptor | Adrenergic receptor | C00031079 | 1 / 0 |
| O94956 | Solute carrier organic anion transporter family member 2B1 | Unclassified protein | C00031079 | 0 / 0 |
| P28223 | 5-hydroxytryptamine receptor 2A | Serotonin receptor | C00031079 | 0 / 0 |
| P28335 | 5-hydroxytryptamine receptor 2C | Serotonin receptor | C00031079 | 0 / 0 |
| P35372 | Mu-type opioid receptor | Opioid receptor | C00031079 | 0 / 0 |
| P08173 | Muscarinic acetylcholine receptor M4 | Acetylcholine receptor | C00031079 | 0 / 0 |
| P25103 | Substance-P receptor | Neurokinin receptor | C00031079 | 0 / 0 |
| P25105 | Platelet-activating factor receptor | PAF receptor | C00031079 | 0 / 0 |
| P33032 | Melanocortin receptor 5 | Melanocortin receptor | C00031079 | 0 / 0 |
| Q00796 | Sorbitol dehydrogenase | Enzyme | C00002503 | 0 / 0 |
| P19838 | Nuclear factor NF-kappa-B p105 subunit | Transcription Factor | C00031079 | 0 / 0 |
| P16050 | Arachidonate 15-lipoxygenase | Enzyme | C00002493 | 0 / 0 |
| O15244 | Solute carrier family 22 member 2 | Drug uniporter | C00031079 | 0 / 0 |
| Q9HCR9 | Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A | PDE_11A | C00031079 | 1 / 1 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00031079 | 1 / 1 |
| Q9UIF8 | Bromodomain adjacent to zinc finger domain protein 2B | Unclassified protein | C00031079 | 0 / 0 |
| P05181 | Cytochrome P450 2E1 | Cytochrome P450 2E1 | C00031079 | 0 / 0 |
| P02545 | Prelamin-A/C | Unclassified protein | C00031079 | 11 / 10 |
| Q6W5P4 | Neuropeptide S receptor | Neuropeptide receptor | C00031079 | 1 / 0 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00031079 | 0 / 0 |
| P22309 | UDP-glucuronosyltransferase 1-1 | Enzyme | C00002503 | 5 / 1 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00031079 | 4 / 3 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00031079 | 0 / 0 |
| P10275 | Androgen receptor | NR3C4 | C00031079 | 3 / 4 |
| P23975 | Sodium-dependent noradrenaline transporter | Norepinephrine | C00031079 | 1 / 1 |
| P25100 | Alpha-1D adrenergic receptor | Adrenergic receptor | C00031079 | 0 / 0 |
| P30542 | Adenosine receptor A1 | Adenosine receptor | C00031079 | 0 / 0 |
| P18089 | Alpha-2B adrenergic receptor | Adrenergic receptor | C00031079 | 0 / 0 |
| P24557 | Thromboxane-A synthase | Cytochrome P450 5A1 | C00031079 | 1 / 1 |
| Q9NP56 | cAMP-specific 3',5'-cyclic phosphodiesterase 7B | PDE_7B | C00031079 | 0 / 0 |
| P06239 | Tyrosine-protein kinase Lck | Src | C00031079 | 0 / 1 |
| O00408 | cGMP-dependent 3',5'-cyclic phosphodiesterase | PDE_2A | C00031079 | 0 / 0 |
| P25025 | C-X-C chemokine receptor type 2 | CXC chemokine receptor | C00031079 | 0 / 0 |
| P80365 | Corticosteroid 11-beta-dehydrogenase isozyme 2 | Enzyme | C00002503 | 1 / 1 |
| O14980 | Exportin-1 | Unclassified protein | C00002488 | 0 / 0 |
| Q14145 | Kelch-like ECH-associated protein 1 | Unclassified protein | C00031079 | 0 / 0 |
| Q9Y6L6 | Solute carrier organic anion transporter family member 1B1 | Electrochemical transporter | C00031079 | 1 / 0 |
| P40225 | Thrombopoietin | Unclassified protein | C00031079 | 1 / 1 |
| O00167 | Eyes absent homolog 2 | Enzyme | C00031079 | 0 / 0 |
| Q16637 | Survival motor neuron protein | Unclassified protein | C00031079 | 4 / 1 |
| P04637 | Cellular tumor antigen p53 | Transcription Factor | C00000584 | 7 / 37 |
| O75874 | Isocitrate dehydrogenase [NADP] cytoplasmic | Enzyme | C00031079 | 1 / 0 |
| Q8IUX4 | DNA dC->dU-editing enzyme APOBEC-3F | Enzyme | C00031079 | 0 / 0 |
| O15440 | Multidrug resistance-associated protein 5 | Unclassified protein | C00031079 | 0 / 0 |
| P22310 | UDP-glucuronosyltransferase 1-4 | Enzyme | C00002503 | 3 / 0 |
| Q08493 | cAMP-specific 3',5'-cyclic phosphodiesterase 4C | PDE_4C | C00031079 | 0 / 0 |
| Q07343 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | PDE_4B | C00031079 | 0 / 0 |
| P27815 | cAMP-specific 3',5'-cyclic phosphodiesterase 4A | PDE_4A | C00031079 | 0 / 0 |
| Q08499 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | PDE_4D | C00031079 | 1 / 0 |
| P18545 | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma | PDE_6G | C00031079 | 1 / 1 |
| O43924 | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | PDE_6D | C00031079 | 0 / 0 |
| P51160 | Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' | PDE_6C | C00031079 | 1 / 1 |
| Q13956 | Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma | PDE_6H | C00031079 | 1 / 1 |
| P16499 | Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha | PDE_6A | C00031079 | 1 / 1 |
| P35913 | Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta | PDE_6B | C00031079 | 2 / 2 |
| Q86TP1 | Protein prune homolog | Enzyme | C00031079 | 0 / 0 |
| Q13370 | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | PDE_3B | C00031079 | 0 / 0 |
| Q14432 | cGMP-inhibited 3',5'-cyclic phosphodiesterase A | PDE_3A | C00031079 | 0 / 0 |
| Q14123 | Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C | PDE_1C | C00031079 | 0 / 0 |
| P54750 | Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A | PDE_1A | C00031079 | 0 / 0 |
| Q01064 | Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B | PDE_1B | C00031079 | 0 / 0 |
| P07900 | Heat shock protein HSP 90-alpha | Other cytosolic protein | C00031079 | 0 / 0 |
| P08238 | Heat shock protein HSP 90-beta | Other cytosolic protein | C00031079 | 0 / 0 |
| Q9NY46 | Sodium channel protein type 3 subunit alpha | SCN alpha, NaV1.x | C00031079 | 0 / 0 |
| Q99250 | Sodium channel protein type 2 subunit alpha | SCN alpha, NaV1.x | C00031079 | 2 / 2 |
| P35498 | Sodium channel protein type 1 subunit alpha | SCN alpha, NaV1.x | C00031079 | 3 / 2 |
| Q13946 | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A | PDE_7A | C00031079 | 0 / 0 |
| O94925 | Glutaminase kidney isoform, mitochondrial | Enzyme | C00002503 | 0 / 0 |
| P01215 | Glycoprotein hormones alpha chain | Unclassified protein | C00000584 | 0 / 3 |
| Q13148 | TAR DNA-binding protein 43 | Unclassified protein | C00031079 | 1 / 1 |
49 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 8644 | AKR1C3, DD3, DDX, HA1753, HAKRB, HAKRe, HSD17B5, PGFS, hluPGFS | aldo-keto reductase family 1, member C3 (EC:1.3.1.20 1.1.1.188 1.1.1.239 1.1.1.64 1.1.1.112 1.1.1.357) |
C00002503
|
| 8574 | AKR7A2, AFAR, AFAR1, AFB1-AR1, AKR7 | aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) (EC:1.1.1.n11) |
C00002503
|
| 581 | BAX, BCL2L4 | BCL2-associated X protein |
C00002503
|
| 596 | BCL2, Bcl-2, PPP1R50 | B-cell CLL/lymphoma 2 |
C00002503
|
| 595 | CCND1, BCL1, D11S287E, PRAD1, U21B31 | cyclin D1 |
C00002503
|
| 1548 | CYP2A6, CPA6, CYP2A, CYP2A3, CYPIIA6, P450C2A, P450PB | cytochrome P450, family 2, subfamily A, polypeptide 6 (EC:1.14.14.1) |
C00002503
|
| 6817 | SULT1A1, HAST1/HAST2, P-PST, PST, ST1A1, ST1A3, STP, STP1, TSPST1 | sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 (EC:2.8.2.1) |
C00002503
|
| 54600 | UGT1A9, HLUGP4, LUGP4, UDPGT, UDPGT_1-9, UGT-1I, UGT1-09, UGT1-9, UGT1.9, UGT1AI, UGT1I | UDP glucuronosyltransferase 1 family, polypeptide A9 (EC:2.4.1.17) |
C00002503
|
| 7366 | UGT2B15, HLUG4, UDPGT_2B8, UDPGT2B15, UDPGTH3, UGT2B8 | UDP glucuronosyltransferase 2 family, polypeptide B15 (EC:2.4.1.17) |
C00002503
|
| 2180 | ACSL1, ACS1, FACL1, FACL2, LACS, LACS1, LACS2 | acyl-CoA synthetase long-chain family member 1 (EC:6.2.1.3) |
C00002488
|
| 1374 | CPT1A, CPT1, CPT1-L, L-CPT1 | carnitine palmitoyltransferase 1A (liver) (EC:2.3.1.21) |
C00002488
|
| 4313 | MMP2, CLG4, CLG4A, MMP-II, MONA, TBE-1 | matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24) |
C00002488
|
| 4318 | MMP9, CLG4B, GELB, MANDP2, MMP-9 | matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) |
C00002488
|
| 4792 | NFKBIA, IKBA, MAD-3, NFKBI | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha |
C00002488
|
| 5465 | PPARA, NR1C1, PPAR, PPARalpha, hPPAR | peroxisome proliferator-activated receptor alpha |
C00002488
|
| 5970 | RELA, NFKB3, p65 | v-rel avian reticuloendotheliosis viral oncogene homolog A |
C00002488
|
| 10257 | ABCC4, EST170205, MOAT-B, MOATB, MRP4 | ATP-binding cassette, sub-family C (CFTR/MRP), member 4 |
C00031079
|
| 348 | APOE, AD2, LDLCQ5, LPG | apolipoprotein E |
C00031079
|
| 598 | BCL2L1, BCL-XL/S, BCL2L, BCLX, BCLXL, BCLXS, Bcl-X, PPP1R52, bcl-xL, bcl-xS | BCL2-like 1 |
C00031079
|
| 836 | CASP3, CPP32, CPP32B, SCA-1 | caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) |
C00031079
|
| 840 | CASP7, CASP-7, CMH-1, ICE-LAP3, LICE2, MCH3 | caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) |
C00031079
|
| 841 | CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5 | caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) |
C00031079
|
| 959 | CD40LG, CD154, CD40L, HIGM1, IGM, IMD3, T-BAM, TNFSF5, TRAP, gp39, hCD40L | CD40 ligand |
C00031079
|
| 8837 | CFLAR, CASH, CASP8AP1, CLARP, Casper, FLAME, FLAME-1, FLAME1, FLIP, I-FLICE, MRIT, c-FLIP, c-FLIPL, c-FLIPR, c-FLIPS | CASP8 and FADD-like apoptosis regulator |
C00031079
|
| 1277 | COL1A1, OI4 | collagen, type I, alpha 1 |
C00031079
|
| 1281 | COL3A1, EDS4A | collagen, type III, alpha 1 |
C00031079
|
| 56616 | DIABLO, DFNA64, SMAC | diablo, IAP-binding mitochondrial protein |
C00031079
|
| 8772 | FADD, MORT1 | Fas (TNFRSF6)-associated via death domain |
C00031079
|
| 2353 | FOS, AP-1, C-FOS, p55 | FBJ murine osteosarcoma viral oncogene homolog |
C00031079
|
| 3553 | IL1B, IL-1, IL1-BETA, IL1F2 | interleukin 1, beta |
C00031079
|
| 3643 | INSR, CD220, HHF5 | insulin receptor (EC:2.7.10.1) |
C00031079
|
| 5599 | MAPK8, JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c | mitogen-activated protein kinase 8 (EC:2.7.11.24) |
C00031079
|
| 4879 | NPPB, BNP | natriuretic peptide B |
C00031079
|
| 5004 | ORM1, AGP-A, AGP1, ORM | orosomucoid 1 |
C00031079
|
| 5005 | ORM2, AGP-B, AGP-B', AGP2 | orosomucoid 2 |
C00031079
|
| 10846 | PDE10A, HSPDE10A | phosphodiesterase 10A (EC:3.1.4.35 3.1.4.17) |
C00031079
|
| 50940 | PDE11A, PPNAD2 | phosphodiesterase 11A (EC:3.1.4.35 3.1.4.17) |
C00031079
|
| 8654 | PDE5A, CGB-PDE, CN5A, PDE5 | phosphodiesterase 5A, cGMP-specific (EC:3.1.4.35) |
C00031079
|
| 5150 | PDE7A, HCP1, PDE7 | phosphodiesterase 7A (EC:3.1.4.17) |
C00031079
|
| 27115 | PDE7B, bA472E5.1 | phosphodiesterase 7B (EC:3.1.4.17) |
C00031079
|
| 5151 | PDE8A, HsT19550 | phosphodiesterase 8A (EC:3.1.4.17) |
C00031079
|
| 8622 | PDE8B, ADSD, PPNAD3 | phosphodiesterase 8B (EC:3.1.4.17) |
C00031079
|
| 5327 | PLAT, T-PA, TPA | plasminogen activator, tissue (EC:3.4.21.68) |
C00031079
|
| 1827 | RCAN1, ADAPT78, CSP1, DSC1, DSCR1, MCIP1, RCN1 | regulator of calcineurin 1 |
C00031079
|
| 2030 | SLC29A1, ENT1 | solute carrier family 29 (equilibrative nucleoside transporter), member 1 |
C00031079
|
| 3177 | SLC29A2, DER12, ENT2, HNP36 | solute carrier family 29 (equilibrative nucleoside transporter), member 2 |
C00031079
|
| 6521 | SLC4A1, AE1, BND3, CD233, DI, EMPB3, EPB3, FR, RTA1A, SW, WD, WD1, WR | solute carrier family 4 (anion exchanger), member 1 |
C00031079
|
| 7040 | TGFB1, CED, DPD1, LAP, TGFB, TGFbeta | transforming growth factor, beta 1 |
C00031079
|
| 7422 | VEGFA, MVCD1, VEGF, VPF | vascular endothelial growth factor A |
C00031079
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (149)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #100100 | Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism |
P20309
|
| #614613 | Acrodysostosis 2, with or without hormone resistance; acrdys2 |
Q08499
|
| #219080 | Acth-independent macronodular adrenal hyperplasia; aimah |
P63092
|
| #202300 | Adrenocortical carcinoma, hereditary; adcc |
P04637
|
| #103470 | Albinism, ocular, with sensorineural deafness |
P14679
|
| #203100 | Albinism, oculocutaneous, type ia; oca1a |
P14679
|
| #606952 | Albinism, oculocutaneous, type ib; oca1b |
P14679
|
| #103780 | Alcohol dependence |
P08172
P14416 P31645 |
| #612069 | Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 |
Q13148
|
| #614373 | Amyotrophic lateral sclerosis 16, juvenile; als16 |
Q99720
|
| #300068 | Androgen insensitivity syndrome; ais |
P10275
|
| #312300 | Androgen insensitivity, partial; pais |
P10275
|
| #218030 | Apparent mineralocorticoid excess; ame |
P80365
|
| #613546 | Aromatase deficiency |
P11511
|
| #139300 | Aromatase excess syndrome; aexs |
P11511
|
| #608584 | Asthma-related traits, susceptibility to, 2 |
Q6W5P4
|
| #208900 | Ataxia-telangiectasia; at |
Q13315
|
| #614740 | Basal cell carcinoma, susceptibility to, 7; bcc7 |
P04637
|
| #601816 | Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 |
P22309
|
| #210900 | Bloom syndrome; blm |
P54132
|
| #602025 | Body mass index quantitative trait locus 9; bmiq9 |
P41968
|
| #114480 | Breast cancer |
P38398
|
| #604370 | Breast-ovarian cancer, familial, susceptibility to, 1; brovca1 |
P38398
|
| #300615 | Brunner syndrome |
P21397
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #118300 | Charcot-marie-tooth disease and deafness |
Q01453
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #118220 | Charcot-marie-tooth disease, demyelinating, type 1a; cmt1a |
Q01453
|
| #114500 | Colorectal cancer; crc |
P84022
|
| #613093 | Cone dystrophy 4; cod4 |
P51160
|
| #604931 | Cortisone reductase deficiency 1; cortrd1 |
P28845
|
| #218800 | Crigler-najjar syndrome, type i |
P22309
P22310 |
| #606785 | Crigler-najjar syndrome, type ii |
P22309
P22310 |
| #162800 | Cyclic neutropenia |
P08246
|
| #612522 | Diabetes mellitus, insulin-dependent, 22; iddm22 |
P51681
|
| #119900 | Digital clubbing, isolated congenital |
P15428
|
| #607208 | Dravet syndrome |
P35498
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #237500 | Dubin-johnson syndrome; djs |
Q92887
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #613721 | Epileptic encephalopathy, early infantile, 11; eiee11 |
Q99250
|
| #133239 | Esophageal cancer |
P04637
|
| #615363 | Estrogen resistance; estrr |
P03372
|
| #301500 | Fabry disease |
P06280
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #613659 | Gastric cancer |
P04626
|
| #137215 | Gastric cancer, hereditary diffuse; hdgc |
P04626
|
| #608013 | Gaucher disease, perinatal lethal |
P04062
|
| #230800 | Gaucher disease, type i |
P04062
|
| #230900 | Gaucher disease, type ii |
P04062
|
| #231000 | Gaucher disease, type iii |
P04062
|
| #231005 | Gaucher disease, type iiic |
P04062
|
| #604403 | Generalized epilepsy with febrile seizures plus, type 2; gefsp2 |
P35498
|
| #231095 | Ghosal hematodiaphyseal dysplasia; ghdd |
P24557
|
| #143500 | Gilbert syndrome |
P22309
P22310 |
| #137800 | Glioma susceptibility 1; glm1 |
O75874
P04626 |
| #232300 | Glycogen storage disease ii |
P10253
|
| #139393 | Guillain-barre syndrome, familial; gbs |
Q01453
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #609423 | Human immunodeficiency virus type 1, susceptibility to |
P41597
P51681 |
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #237450 | Hyperbilirubinemia, rotor type; hblrr |
Q9NPD5
Q9Y6L6 |
| #237900 | Hyperbilirubinemia, transient familial neonatal; hblrtfn |
P22309
|
| #143860 | Hyperchlorhidrosis, isolated |
O43570
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #145900 | Hypertrophic neuropathy of dejerine-sottas |
Q01453
|
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 |
P15428
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #612244 | Inflammatory bowel disease 13; ibd13 |
P08183
|
| #603932 | Intervertebral disc disease; idd |
P14780
|
| #151623 | Li-fraumeni syndrome 1; lfs1 |
P04637
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #613795 | Loeys-dietz syndrome, type 3; lds3 |
P84022
|
| #613688 | Long qt syndrome 2; lqt2 |
Q12809
|
| #211980 | Lung cancer |
P00533
P04626 P04637 |
| #608516 | Major depressive disorder; mdd |
P08172
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #174800 | Mccune-albright syndrome; mas |
P63092
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| %300852 | Mental retardation, x-linked 88; mrx88 |
P50052
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #613073 | Metaphyseal anadysplasia 2; mandp2 |
P14780
|
| #609634 | Migraine, familial hemiplegic, 3; fhm3 |
P35498
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #126200 | Multiple sclerosis, susceptibility to; ms |
P08575
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #159900 | Myoclonic dystonia |
P14416
|
| #160900 | Myotonic dystrophy 1; dm1 |
Q9NR56
|
| #162500 | Neuropathy, hereditary, with liability to pressure palsies; hnpp |
Q01453
|
| #202700 | Neutropenia, severe congenital, 1, autosomal dominant; scn1 |
P08246
|
| #257200 | Niemann-pick disease, type a |
P17405
|
| #607616 | Niemann-pick disease, type b |
P17405
|
| #257220 | Niemann-pick disease, type c1; npc1 |
O15118
|
| #163500 | Night blindness, congenital stationary, autosomal dominant 2; csnbad2 |
P35913
|
| #601665 | Obesity |
P32245
|
| #164230 | Obsessive-compulsive disorder; ocd |
P31645
|
| #604715 | Orthostatic intolerance |
P23975
|
| #166350 | Osseous heteroplasia, progressive; poh |
P63092
|
| #259730 | Osteopetrosis, autosomal recessive 3; optb3 |
P00918
|
| #167000 | Ovarian cancer |
P04626
P38398 |
| #614320 | Pancreatic cancer, susceptibility to, 4; pnca4 |
P38398
|
| #260500 | Papilloma of choroid plexus; cpp |
P04637
|
| #168600 | Parkinson disease, late-onset; pd |
P04062
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #613135 | Parkinsonism-dystonia, infantile; pkdys |
Q01959
|
| #172700 | Pick disease of brain |
P10636
|
| #610475 | Pigmented nodular adrenocortical disease, primary, 2; ppnad2 |
Q9HCR9
|
| #614190 | Pigmented nodular adrenocortical disease, primary, 3; ppnad3 |
O95263
|
| #102200 | Pituitary adenoma, growth hormone-secreting |
P63092
|
| #103580 | Pseudohypoparathyroidism, type ia; php1a |
P63092
|
| #603233 | Pseudohypoparathyroidism, type ib; php1b |
P63092
|
| #612462 | Pseudohypoparathyroidism, type ic; php1c |
P63092
|
| #607276 | Resting heart rate, variation in |
P08588
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #610024 | Retinal cone dystrophy 3a; rcd3a |
Q13956
|
| #613801 | Retinitis pigmentosa 40; rp40 |
P35913
|
| #613810 | Retinitis pigmentosa 43; rp43 |
P16499
|
| #613582 | Retinitis pigmentosa 57; rp57 |
P18545
|
| #604906 | Schizophrenia 9; sczd9 |
P49798
|
| #181500 | Schizophrenia; sczd |
P49798
|
| #607745 | Seizures, benign familial infantile, 3; bfis3 |
Q99250
|
| #608971 | Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive |
P08575
|
| #609620 | Short qt syndrome 1; sqt1 |
Q12809
|
| #601800 | Skin/hair/eye pigmentation, variation in, 3; shep3 |
P14679
|
| #313200 | Spinal and bulbar muscular atrophy, x-linked 1; smax1 |
P10275
|
| #253300 | Spinal muscular atrophy, type i; sma1 |
Q16637
|
| #253550 | Spinal muscular atrophy, type ii; sma2 |
Q16637
|
| #253400 | Spinal muscular atrophy, type iii; sma3 |
Q16637
|
| #271150 | Spinal muscular atrophy, type iv; sma4 |
Q16637
|
| #183090 | Spinocerebellar ataxia 2; sca2 |
Q99700
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
| #275355 | Squamous cell carcinoma, head and neck; hnscc |
P04637
|
| #609161 | Striatal degeneration, autosomal dominant; adsd |
O95263
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #187950 | Thrombocythemia 1; thcyt1 |
P40225
|
| #188570 | Thyroid hormone resistance, generalized, autosomal dominant; grth |
P10828
|
| #274300 | Thyroid hormone resistance, generalized, autosomal recessive; grth |
P10828
|
| #145650 | Thyroid hormone resistance, selective pituitary; prth |
P10828
|
| #190300 | Tremor, hereditary essential, 1; etm1 |
P35462
|
| #610379 | West nile virus, susceptibility to |
P51681
|
| #278300 | Xanthinuria, type i |
P47989
|
| #112100 | Yt blood group antigen |
P22303
|
KEGG DISEASE (121)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
P04637 (related) |
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00136 | Niemann-Pick disease type C (NPC) |
O15118
(related)
|
| H01302 | Hyperchlorhidrosis isolated (HCHLH) |
O43570
(related)
|
| H00021 | Renal cell carcinoma |
O43570
(marker)
P04637 (marker) Q16790 (marker) |
| H00260 | Pigmented micronodular adrenocortical disease (PPNAD) |
O95263
(related)
Q9HCR9 (related) |
| H00016 | Oral cancer |
P00533
(related)
P00533 (marker) P04637 (related) P04637 (marker) |
| H00017 | Esophageal cancer |
P00533
(related)
P04637 (related) P04637 (marker) P35354 (related) |
| H00018 | Gastric cancer |
P00533
(related)
P04626 (related) P04637 (related) |
| H00022 | Bladder cancer |
P00533
(related)
P04626 (related) P04637 (related) |
| H00028 | Choriocarcinoma |
P00533
(related)
P03956 (related) P04626 (related) P04637 (related) |
| H00030 | Cervical cancer |
P00533
(related)
P04626 (related) |
| H00042 | Glioma |
P00533
(related)
P00533 (marker) P04637 (related) P04637 (marker) |
| H00055 | Laryngeal cancer |
P00533
(related)
P00533 (marker) P04637 (related) P04637 (marker) |
| H00241 | Combined proximal and distal renal tubular acidosis (RTA type 3) |
P00918
(related)
|
| H00436 | Osteopetrosis |
P00918
(related)
|
| H00081 | Hashimoto's thyroiditis |
P01215
(marker)
|
| H00082 | Graves' disease |
P01215
(marker)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P01215
(marker)
P16473 (related) |
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
Q01453 (related) |
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00026 | Endometrial Cancer |
P03372
(marker)
P04626 (related) P04637 (related) Q92731 (marker) |
| H00066 | Lewy body dementia (LBD) |
P04062
(related)
|
| H00126 | Gaucher disease |
P04062
(related)
|
| H00426 | Defects in the degradation of ganglioside |
P04062
(related)
|
| H00810 | Progressive myoclonic epilepsy (PME) |
P04062
(related)
|
| H00599 | 46,XX disorders of sex development (Disorders related to androgen excess) |
P04150
(related)
P11511 (related) |
| H00019 | Pancreatic cancer |
P04626
(related)
P04637 (related) P04637 (marker) |
| H00027 | Ovarian cancer |
P04626
(related)
P04637 (related) P38398 (related) |
| H00031 | Breast cancer |
P04626
(related)
P04626 (marker) P04637 (related) P38398 (related) |
| H00046 | Cholangiocarcinoma |
P04626
(related)
P04637 (related) P35354 (related) |
| H00004 | Chronic myeloid leukemia (CML) |
P04637
(related)
|
| H00005 | Chronic lymphocytic leukemia (CLL) |
P04637
(related)
Q13315 (related) |
| H00006 | Hairy-cell leukemia |
P04637
(related)
|
| H00008 | Burkitt lymphoma |
P04637
(related)
|
| H00009 | Adult T-cell leukemia |
P04637
(related)
|
| H00010 | Multiple myeloma |
P04637
(related)
|
| H00013 | Small cell lung cancer |
P04637
(related)
|
| H00014 | Non-small cell lung cancer |
P04637
(related)
|
| H00015 | Malignant pleural mesothelioma |
P04637
(related)
|
| H00020 | Colorectal cancer |
P04637
(related)
P04637 (marker) |
| H00025 | Penile cancer |
P04637
(related)
P04637 (marker) P14780 (related) P35354 (related) |
| H00029 | Vulvar cancer |
P04637
(related)
|
| H00032 | Thyroid cancer |
P04637
(related)
|
| H00036 | Osteosarcoma |
P04637
(related)
P08684 (marker) |
| H00038 | Malignant melanoma |
P04637
(related)
P14679 (marker) |
| H00039 | Basal cell carcinoma |
P04637
(related)
|
| H00040 | Squamous cell carcinoma |
P04637
(related)
|
| H00041 | Kaposi's sarcoma |
P04637
(related)
|
| H00044 | Cancer of the anal canal |
P04637
(related)
|
| H00047 | Gallbladder cancer |
P04637
(related)
|
| H00048 | Hepatocellular carcinoma |
P04637
(related)
|
| H00881 | Li-Fraumeni syndrome |
P04637
(related)
|
| H01007 | Choroid plexus papilloma |
P04637
(related)
|
| H00093 | Combined immunodeficiencies (CIDs) |
P06239
(related)
|
| H00125 | Fabry disease |
P06280
(related)
|
| H00079 | Asthma |
P07550
(related)
|
| H00100 | Neutropenic disorders |
P08246
(related)
|
| H00091 | T-B+Severe combined immunodeficiencies (SCIDs) |
P08575
(related)
|
| H00069 | Glycogen storage diseases (GSD) |
P10253
(related)
|
| H00024 | Prostate cancer |
P10275
(related)
|
| H00062 | Spinal and bulbar muscular atrophy (SBMA) |
P10275
(related)
|
| H00608 | 46,XY disorders of sex development (Disorders in androgen synthesis or action) |
P10275
(related)
|
| H00609 | 46,XY disorders of sex development (Other) |
P10275
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
Q13148 (related) |
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00249 | Thyroid hormone resistance syndrome |
P10828
(related)
|
| H00794 | Aromatase excess syndrome |
P11511
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00168 | Oculocutaneous albinism (OCA) |
P14679
(related)
|
| H00479 | Metaphyseal dysplasias |
P14780
(related)
|
| H00457 | Primary hypertrophic osteoarthropathy (PHO) |
P15428
(related)
|
| H01246 | Isolated congenital nail clubbing (ICNC) |
P15428
(related)
|
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H00527 | Retinitis pigmentosa (RP) |
P16499
(related)
P18545 (related) P35913 (related) |
| H00137 | Niemann-Pick disease (NPD) typeA and B |
P17405
(related)
|
| H00424 | Defects in the degradation of sphingomyelin |
P17405
(related)
|
| H00548 | Brunner syndrome |
P21397
(related)
|
| H00208 | Hyperbilirubinemia |
P22309
(related)
Q92887 (related) |
| H01031 | Orthostatic intolerance (OI) |
P23975
(related)
|
| H00490 | Diaphyseal dysplasia with anemia (Ghosal) |
P24557
(related)
|
| H01111 | Cortisone reductase deficiency (CRD) |
P28845
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00775 | Familial or sporadic hemiplegic migraine |
P35498
(related)
|
| H00783 | Febrile seizures |
P35498
(related)
|
| H00787 | Congenital stationary night blindness (CSNB) |
P35913
(related)
|
| H00227 | Congenital amegakaryocytic thrombocytopenia (CAMT) |
P40225
(marker)
|
| H00192 | Xanthinuria |
P47989
(related)
|
| H00480 | Non-syndromic X-linked mental retardation |
P50052
(related)
Q99714 (related) |
| H00481 | Cone-rod dystrophy and cone dystrophy |
P51160
(related)
Q13956 (related) |
| H00094 | DNA repair defects |
P54132
(related)
Q13315 (related) |
| H00296 | Defects in RecQ helicases |
P54132
(related)
|
| H00244 | Pseudohypoparathyroidism |
P63092
(related)
|
| H00441 | Progressive osseous heteroplasia (POH) |
P63092
(related)
|
| H00501 | Fibrous dysplasia, polyostotic |
P63092
(related)
|
| H00259 | Apparent mineralocorticoid excess syndrome |
P80365
(related)
|
| H01296 | Hereditary neuropathy with liability to pressure palsies (HNPP) |
Q01453
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q03164
(related)
Q03164 (marker) |
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00720 | Long QT syndrome |
Q12809
(related)
|
| H00725 | Short QT syndrome |
Q12809
(related)
|
| H00064 | Ataxia telangiectasia (AT) |
Q13315
(related)
|
| H00848 | Ataxia with ocular apraxia (AOA) |
Q13315
(related)
|
| H00455 | Spinal muscular atrophy (SMA) |
Q16637
(related)
|
| H00606 | Early infantile epileptic encephalopathy |
Q99250
(related)
|
| H00806 | Benign familial neonatal and infantile epilepsies |
Q99250
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q99700
(related)
Q9NUW8 (related) |
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|
Diseases related to CTD interactions
81 disease in interactions with metabolites
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| C538231 | Adenocarcinoma of lung |
C00002488
|
| D003920 | Diabetes Mellitus |
C00002488
|
| D006943 | Hyperglycemia |
C00002488
|
| D009361 | Neoplasm Invasiveness |
C00002488
|
| D015746 | Abdominal Pain |
C00031079
|
| D000138 | Acidosis |
C00031079
|
| D000544 | Alzheimer Disease |
C00031079
|
| D000707 | Anaphylaxis |
C00031079
|
| D000787 | Angina Pectoris |
C00031079
|
| D000799 | Angioedema |
C00031079
|
| D001002 | Anuria |
C00031079
|
| D001049 | Apnea |
C00031079
|
| D001145 | Arrhythmias, Cardiac |
C00031079
|
| D001281 | Atrial Fibrillation |
C00031079
|
| D054537 | Atrioventricular Block |
C00031079
|
| D001919 | Bradycardia |
C00031079
|
| D001927 | Brain Diseases |
C00031079
|
| D002545 | Brain Ischemia |
C00031079
|
| D001986 | Bronchial Spasm |
C00031079
|
| D002311 | Cardiomyopathy, Dilated |
C00031079
|
| D002637 | Chest Pain |
C00031079
|
| D002779 | Cholestasis |
C00031079
|
| D003324 | Coronary Artery Disease |
C00031079
|
| D003327 | Coronary Disease |
C00031079
|
| D003329 | Coronary Vasospasm |
C00031079
|
| D003967 | Diarrhea |
C00031079
|
| D004108 | Dilatation, Pathologic |
C00031079
|
| D004244 | Dizziness |
C00031079
|
| D004408 | Dysgeusia |
C00031079
|
| D004409 | Dyskinesia, Drug-Induced |
C00031079
|
| D004417 | Dyspnea |
C00031079
|
| D005483 | Flushing |
C00031079
|
| D042882 | Gallstones |
C00031079
|
| D005767 | Gastrointestinal Diseases |
C00031079
|
| D005921 | Glomerulonephritis |
C00031079
|
| D006212 | Hallucinations |
C00031079
|
| D006261 | Headache |
C00031079
|
| D006323 | Heart Arrest |
C00031079
|
| D006327 | Heart Block |
C00031079
|
| D006331 | Heart Diseases |
C00031079
|
| D006333 | Heart Failure |
C00031079
|
| D006463 | Hemolytic-Uremic Syndrome |
C00031079
|
| D006470 | Hemorrhage |
C00031079
|
| D006940 | Hyperemia |
C00031079
|
| D006973 | Hypertension |
C00031079
|
| D006976 | Hypertension, Pulmonary |
C00031079
|
| D007022 | Hypotension |
C00031079
|
| D007174 | Impulse Control Disorders |
C00031079
|
| D007431 | Intraoperative Complications |
C00031079
|
| D007511 | Ischemia |
C00031079
|
| D002546 | Ischemic Attack, Transient |
C00031079
|
| D007964 | Leukocytosis |
C00031079
|
| D008881 | Migraine Disorders |
C00031079
|
| D008944 | Mitral Valve Insufficiency |
C00031079
|
| D009072 | Moyamoya Disease |
C00031079
|
| D009203 | Myocardial Infarction |
C00031079
|
| D017202 | Myocardial Ischemia |
C00031079
|
| D017682 | Myocardial Stunning |
C00031079
|
| D009325 | Nausea |
C00031079
|
| D009369 | Neoplasms |
C00031079
|
| D009401 | Nephrosis |
C00031079
|
| D010146 | Pain |
C00031079
|
| D010292 | Paresthesia |
C00031079
|
| D056627 | Peritoneal Fibrosis |
C00031079
|
| D020795 | Photophobia |
C00031079
|
| D011507 | Proteinuria |
C00031079
|
| D015427 | Reperfusion Injury |
C00031079
|
| D012770 | Shock, Cardiogenic |
C00031079
|
| D054138 | Sinus Arrest, Cardiac |
C00031079
|
| D020521 | Stroke |
C00031079
|
| D013345 | Subarachnoid Hemorrhage |
C00031079
|
| D013375 | Substance Withdrawal Syndrome |
C00031079
|
| D013575 | Syncope |
C00031079
|
| D017180 | Tachycardia, Ventricular |
C00031079
|
| D054549 | Takotsubo Cardiomyopathy |
C00031079
|
| D013927 | Thrombosis |
C00031079
|
| D020246 | VENOUS THROMBOSIS |
C00031079
|
| D018487 | Ventricular Dysfunction, Left |
C00031079
|
| D018879 | Ventricular Premature Complexes |
C00031079
|
| D014717 | Vertigo |
C00031079
|
| D014839 | Vomiting |
C00031079
|