PCIDB

KNApSAcK Metabolite C00031079

Metabolite

KNApSAcK Entry

id C00031079
Name Prandiol / Protangix
CAS RN 58-32-2
Standard InChI InChI=1S/C24H40N8O4/c33-15-11-31(12-16-34)23-26-20-19(21(27-23)29-7-3-1-4-8-29)25-24(32(13-17-35)14-18-36)28-22(20)30-9-5-2-6-10-30/h33-36H,1-18H2
Standard InChI (Main Layer) InChI=1S/C24H40N8O4/c33-15-11-31(12-16-34)23-26-20-19(21(27-23)29-7-3-1-4-8-29)25-24(32(13-17-35)14-18-36)28-22(20)30-9-5-2-6-10-30/h33-36H,1-18H2

Cluster

Phytochemical cluster
KCF-S cluster No. 8896

Link

ChEMBL

By standard InChI CHEMBL932
By standard InChI Main Layer CHEMBL932

KEGG

By LinkDB

CTD

By CAS RN D004176

Species

Summary

Plant class

class name count
asterids 2

Family

family name count
Apiaceae 2

List (2)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Heracleum candicans WALL. 40917 Apiaceae asterids Viridiplantae
Prangos biebersteinii 52496 Apiaceae asterids Viridiplantae

Human Protein / Gene in interaction

174 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 CHEMBL932 CHEMBL1614110 (2) CHEMBL1741321 (2)
CHEMBL1909136 (2)
1 / 0
Q16637 Survival motor neuron protein Unclassified protein CHEMBL932 CHEMBL1613842 (2)
4 / 2
Q9Y6L6 Solute carrier organic anion transporter family member 1B1 Electrochemical transporter CHEMBL932 CHEMBL2169429 (1)
1 / 0
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein CHEMBL932 CHEMBL1738312 (1)
0 / 0
O15244 Solute carrier family 22 member 2 Drug uniporter CHEMBL932 CHEMBL2154120 (1)
0 / 0
O94956 Solute carrier organic anion transporter family member 2B1 Unclassified protein CHEMBL932 CHEMBL2169431 (1)
0 / 0
Q96FL8 Multidrug and toxin extrusion protein 1 Cation antiporter CHEMBL932 CHEMBL2154123 (1)
0 / 0
Q99700 Ataxin-2 Unclassified protein CHEMBL932 CHEMBL2114784 (3)
1 / 1
P49798 Regulator of G-protein signaling 4 Unclassified protein CHEMBL932 CHEMBL1794499 (2)
2 / 0
P21728 D(1A) dopamine receptor Dopamine receptor CHEMBL932 CHEMBL1738091 (1) CHEMBL1737859 (1)
CHEMBL1738565 (1) CHEMBL1909139 (2)
0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase CHEMBL932 CHEMBL1909131 (2)
0 / 3
Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH, Kv10-12.x (Ether-a-go-go) CHEMBL932 CHEMBL1794573 (1) CHEMBL1909190 (2)
2 / 2
P08246 Neutrophil elastase S1A CHEMBL932 CHEMBL1909195 (2)
2 / 1
P33765 Adenosine receptor A3 Adenosine receptor CHEMBL932 CHEMBL1909215 (2)
0 / 0
Q16539 Mitogen-activated protein kinase 14 p38 CHEMBL932 CHEMBL1909201 (2)
0 / 0
P49146 Neuropeptide Y receptor type 2 Neuropeptide Y receptor CHEMBL932 CHEMBL1909176 (2)
0 / 0
P10253 Lysosomal alpha-glucosidase Hydrolase CHEMBL932 CHEMBL1614103 (1) CHEMBL1614031 (1)
1 / 1
P29466 Caspase-1 C14 CHEMBL932 CHEMBL1614158 (2) CHEMBL1909193 (2)
0 / 0
P17252 Protein kinase C alpha type Alpha CHEMBL932 CHEMBL1909198 (2)
0 / 0
P27361 Mitogen-activated protein kinase 3 Erk CHEMBL932 CHEMBL1909199 (2)
0 / 0
P14780 Matrix metalloproteinase-9 M10A CHEMBL932 CHEMBL1909197 (2)
2 / 2
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme CHEMBL932 CHEMBL1738600 (1)
0 / 0
Q13315 Serine-protein kinase ATM Atypical serine/threonine protein kinase PIKK subfamily CHEMBL932 CHEMBL1614153 (1)
1 / 4
O15245 Solute carrier family 22 member 1 Drug uniporter CHEMBL932 CHEMBL2154122 (1)
0 / 0
O75604 Ubiquitin carboxyl-terminal hydrolase 2 Enzyme CHEMBL932 CHEMBL1614331 (2) CHEMBL1614474 (1)
CHEMBL1613927 (1)
0 / 0
P02545 Prelamin-A/C Unclassified protein CHEMBL932 CHEMBL1614544 (3)
11 / 10
P16473 Thyrotropin receptor Glycohormone receptor CHEMBL932 CHEMBL1614361 (1)
3 / 2
Q99808 Equilibrative nucleoside transporter 1 Nucleoside uniporter CHEMBL932 CHEMBL823109 (1) CHEMBL894049 (1)
CHEMBL894050 (2) CHEMBL1629189 (1)
0 / 0
P10828 Thyroid hormone receptor beta NR1A2 CHEMBL932 CHEMBL1614554 (1) CHEMBL1613776 (1)
3 / 1
P00918 Carbonic anhydrase 2 Lyase CHEMBL932 CHEMBL1909123 (2)
1 / 2
P07550 Beta-2 adrenergic receptor Adrenergic receptor CHEMBL932 CHEMBL1909092 (2)
0 / 1
P21397 Amine oxidase [flavin-containing] A Oxidoreductase CHEMBL932 CHEMBL1909169 (2)
1 / 1
P25021 Histamine H2 receptor Histamine receptor CHEMBL932 CHEMBL1909157 (2)
0 / 0
P35367 Histamine H1 receptor Histamine receptor CHEMBL932 CHEMBL1909156 (2)
0 / 0
Q01959 Sodium-dependent dopamine transporter Dopamine CHEMBL932 CHEMBL1909143 (2)
1 / 0
P08912 Muscarinic acetylcholine receptor M5 Acetylcholine receptor CHEMBL932 CHEMBL1909174 (2)
0 / 0
P18825 Alpha-2C adrenergic receptor Adrenergic receptor CHEMBL932 CHEMBL1909090 (2)
0 / 0
P13945 Beta-3 adrenergic receptor Adrenergic receptor CHEMBL932 CHEMBL1909093 (2)
0 / 0
P08183 Multidrug resistance protein 1 drug CHEMBL932 CHEMBL1908285 (1) CHEMBL1908286 (1)
CHEMBL1908289 (1) CHEMBL1908291 (1)
CHEMBL1908292 (1) CHEMBL2049767 (1)
CHEMBL2076208 (1) CHEMBL2076213 (1)
CHEMBL2076214 (1) CHEMBL2076217 (1)
CHEMBL2076218 (1)
1 / 0
P25024 C-X-C chemokine receptor type 1 CXC chemokine receptor CHEMBL932 CHEMBL1909127 (2)
0 / 0
P06241 Tyrosine-protein kinase Fyn Src CHEMBL932 CHEMBL1909204 (2)
0 / 0
Q08209 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform Ser_Thr CHEMBL932 CHEMBL1909202 (2)
0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 CHEMBL932 CHEMBL1614027 (2) CHEMBL1741325 (2)
CHEMBL1909135 (2)
0 / 1
O95263 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B PDE_8B CHEMBL932 CHEMBL1629279 (1)
2 / 1
P54132 Bloom syndrome protein Enzyme CHEMBL932 CHEMBL1614522 (1) CHEMBL1614067 (1)
1 / 2
Q9NR56 Muscleblind-like protein 1 Unclassified protein CHEMBL932 CHEMBL1614166 (1)
1 / 0
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily CHEMBL932 CHEMBL1909203 (2)
1 / 11
P14416 D(2) dopamine receptor Dopamine receptor CHEMBL932 CHEMBL1909140 (2)
2 / 0
P23219 Prostaglandin G/H synthase 1 Oxidoreductase CHEMBL932 CHEMBL1909130 (2)
0 / 0
P37288 Vasopressin V1a receptor Vasopressin and oxytocin receptor CHEMBL932 CHEMBL1909120 (2)
0 / 0
P41145 Kappa-type opioid receptor Opioid receptor CHEMBL932 CHEMBL1909181 (2)
0 / 0
Q9Y271 Cysteinyl leukotriene receptor 1 Leukotriene receptor CHEMBL932 CHEMBL1909164 (2)
0 / 0
P29274 Adenosine receptor A2a Adenosine receptor CHEMBL932 CHEMBL1909214 (2)
0 / 0
P25929 Neuropeptide Y receptor type 1 Neuropeptide Y receptor CHEMBL932 CHEMBL1909175 (2)
0 / 0
P50052 Type-2 angiotensin II receptor Angiotensin receptor CHEMBL932 CHEMBL1909096 (2)
1 / 1
O15296 Arachidonate 15-lipoxygenase B Enzyme CHEMBL932 CHEMBL1613800 (1)
0 / 0
P17948 Vascular endothelial growth factor receptor 1 Vegfr CHEMBL932 CHEMBL1909118 (2)
0 / 0
P41968 Melanocortin receptor 3 Melanocortin receptor CHEMBL932 CHEMBL1909166 (2)
1 / 0
P00352 Retinal dehydrogenase 1 Enzyme CHEMBL932 CHEMBL1614458 (7)
0 / 0
P17405 Sphingomyelin phosphodiesterase Enzyme CHEMBL932 CHEMBL1794495 (1)
2 / 2
P11509 Cytochrome P450 2A6 Cytochrome P450 2A6 CHEMBL932 CHEMBL1909133 (2)
0 / 0
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor CHEMBL932 CHEMBL1614456 (1) CHEMBL1613803 (1)
0 / 0
O60658 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A PDE_8A CHEMBL932 CHEMBL1629199 (1)
0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme CHEMBL932 CHEMBL1738606 (3)
0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein CHEMBL932 CHEMBL1794584 (1)
2 / 0
O75496 Geminin Unclassified protein CHEMBL932 CHEMBL1613941 (1) CHEMBL2114843 (4)
CHEMBL2114780 (3)
0 / 0
O15439 Multidrug resistance-associated protein 4 Unclassified protein CHEMBL932 CHEMBL2077068 (1) CHEMBL2078535 (1)
CHEMBL2078618 (1)
0 / 0
P38398 Breast cancer type 1 susceptibility protein Enzyme CHEMBL932 CHEMBL1613817 (2)
4 / 2
P04035 3-hydroxy-3-methylglutaryl-coenzyme A reductase Oxidoreductase CHEMBL932 CHEMBL1909158 (2)
0 / 0
P08913 Alpha-2A adrenergic receptor Adrenergic receptor CHEMBL932 CHEMBL1909088 (2)
0 / 0
P21917 D(4) dopamine receptor Dopamine receptor CHEMBL932 CHEMBL1909142 (2)
0 / 0
P30988 Calcitonin receptor Calcitonin receptor CHEMBL932 CHEMBL1909101 (2)
0 / 0
P35462 D(3) dopamine receptor Dopamine receptor CHEMBL932 CHEMBL1909141 (2)
1 / 0
P41143 Delta-type opioid receptor Opioid receptor CHEMBL932 CHEMBL1909180 (2)
0 / 0
Q92731 Estrogen receptor beta NR3A2 CHEMBL932 CHEMBL1909146 (2)
0 / 1
P41595 5-hydroxytryptamine receptor 2B Serotonin receptor CHEMBL932 CHEMBL1909104 (2)
0 / 0
P25101 Endothelin-1 receptor Endothelin receptor CHEMBL932 CHEMBL1909144 (2)
0 / 0
P30411 B2 bradykinin receptor Bradykinin receptor CHEMBL932 CHEMBL1909100 (2)
0 / 0
P32245 Melanocortin receptor 4 Melanocortin receptor CHEMBL932 CHEMBL1909167 (2)
1 / 0
P32238 Cholecystokinin receptor type A Cholecystokinin receptor CHEMBL932 CHEMBL1909129 (2)
0 / 0
P08311 Cathepsin G S1A CHEMBL932 CHEMBL1909194 (2)
0 / 0
Q99720 Sigma non-opioid intracellular receptor 1 Membrane receptor CHEMBL932 CHEMBL1909110 (2)
1 / 0
P03956 Interstitial collagenase M10A CHEMBL932 CHEMBL1909196 (2)
0 / 1
P32241 Vasoactive intestinal polypeptide receptor 1 Vasoactive intestinal peptide receptor CHEMBL932 CHEMBL1909119 (2)
0 / 0
Q9Y233 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE_10A CHEMBL932 CHEMBL828811 (1)
0 / 0
Q03164 Histone-lysine N-methyltransferase 2A Enzyme CHEMBL932 CHEMBL1614257 (1) CHEMBL1614410 (2)
CHEMBL1614531 (7)
1 / 3
Q9NPD5 Solute carrier organic anion transporter family member 1B3 Electrochemical transporter CHEMBL932 CHEMBL2169430 (1)
1 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme CHEMBL932 CHEMBL1794467 (3)
0 / 0
Q99816 Tumor susceptibility gene 101 protein Unclassified protein CHEMBL932 CHEMBL1614448 (1) CHEMBL1738574 (1)
CHEMBL2114930 (1)
0 / 0
P04150 Glucocorticoid receptor NR3C1 CHEMBL932 CHEMBL1909150 (2)
0 / 1
P08172 Muscarinic acetylcholine receptor M2 Acetylcholine receptor CHEMBL932 CHEMBL1909171 (2)
2 / 0
P11229 Muscarinic acetylcholine receptor M1 Acetylcholine receptor CHEMBL932 CHEMBL1909170 (2)
0 / 0
P21554 Cannabinoid receptor 1 Cannabinoid receptor CHEMBL932 CHEMBL1909122 (2)
0 / 0
P31645 Sodium-dependent serotonin transporter Serotonin CHEMBL932 CHEMBL1909109 (2)
2 / 0
P04626 Receptor tyrosine-protein kinase erbB-2 TK tyrosine-protein kinase EGFR subfamily CHEMBL932 CHEMBL1909205 (2)
5 / 10
P20309 Muscarinic acetylcholine receptor M3 Acetylcholine receptor CHEMBL932 CHEMBL1909172 (2)
1 / 0
P21452 Substance-K receptor Neurokinin receptor CHEMBL932 CHEMBL1909114 (2)
0 / 0
P51679 C-C chemokine receptor type 4 CC chemokine receptor CHEMBL932 CHEMBL1909125 (2)
0 / 0
P51681 C-C chemokine receptor type 5 CC chemokine receptor CHEMBL932 CHEMBL1909126 (2)
3 / 0
P50406 5-hydroxytryptamine receptor 6 Serotonin receptor CHEMBL932 CHEMBL1909108 (2)
0 / 0
P41597 C-C chemokine receptor type 2 CC chemokine receptor CHEMBL932 CHEMBL1909124 (2)
1 / 0
P28482 Mitogen-activated protein kinase 1 Erk CHEMBL932 CHEMBL1909200 (2)
0 / 0
P08575 Receptor-type tyrosine-protein phosphatase C Enzyme CHEMBL932 CHEMBL1909207 (2)
2 / 1
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 CHEMBL932 CHEMBL1741322 (2) CHEMBL1909132 (2)
0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme CHEMBL932 CHEMBL1613910 (2)
3 / 3
Q92887 Canalicular multispecific organic anion transporter 1 Unclassified protein CHEMBL932 CHEMBL1006005 (1)
1 / 1
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme CHEMBL932 CHEMBL1614038 (5)
2 / 2
Q01453 Peripheral myelin protein 22 Unclassified protein CHEMBL932 CHEMBL1614171 (1)
5 / 2
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein CHEMBL932 CHEMBL1738588 (1) CHEMBL1738675 (1)
0 / 0
Q86VL8 Multidrug and toxin extrusion protein 2 Cation antiporter CHEMBL932 CHEMBL2154124 (1)
0 / 0
O76074 cGMP-specific 3',5'-cyclic phosphodiesterase PDE_5A CHEMBL932 CHEMBL762503 (1) CHEMBL822071 (1)
CHEMBL1909186 (2)
0 / 0
P03372 Estrogen receptor NR3A1 CHEMBL932 CHEMBL1909145 (2)
1 / 1
P08588 Beta-1 adrenergic receptor Adrenergic receptor CHEMBL932 CHEMBL1909091 (2)
1 / 0
P22303 Acetylcholinesterase Hydrolase CHEMBL932 CHEMBL1909212 (2)
1 / 0
P28223 5-hydroxytryptamine receptor 2A Serotonin receptor CHEMBL932 CHEMBL1909211 (2)
0 / 0
P28335 5-hydroxytryptamine receptor 2C Serotonin receptor CHEMBL932 CHEMBL1909105 (2)
0 / 0
P35372 Mu-type opioid receptor Opioid receptor CHEMBL932 CHEMBL1909182 (2)
0 / 0
P08173 Muscarinic acetylcholine receptor M4 Acetylcholine receptor CHEMBL932 CHEMBL1909173 (2)
0 / 0
P25103 Substance-P receptor Neurokinin receptor CHEMBL932 CHEMBL1909113 (2)
0 / 0
P25105 Platelet-activating factor receptor PAF receptor CHEMBL932 CHEMBL1909187 (2)
0 / 0
P33032 Melanocortin receptor 5 Melanocortin receptor CHEMBL932 CHEMBL1909168 (2)
0 / 0
P19838 Nuclear factor NF-kappa-B p105 subunit Transcription Factor CHEMBL932 CHEMBL1614274 (1) CHEMBL1613823 (1)
0 / 0
P55210 Caspase-7 C14 CHEMBL932 CHEMBL1613779 (2)
0 / 0
Q9HCR9 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE_11A CHEMBL932 CHEMBL828812 (1)
1 / 1
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 CHEMBL932 CHEMBL1613777 (2) CHEMBL1741323 (2)
CHEMBL1909134 (2)
1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 CHEMBL932 CHEMBL1614108 (2) CHEMBL1613886 (2)
CHEMBL1741324 (2) CHEMBL1909138 (2)
0 / 1
P05181 Cytochrome P450 2E1 Cytochrome P450 2E1 CHEMBL932 CHEMBL1909137 (2)
0 / 0
Q6W5P4 Neuropeptide S receptor Neuropeptide receptor CHEMBL932 CHEMBL1614052 (1) CHEMBL1614355 (1)
CHEMBL1614021 (1)
1 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme CHEMBL932 CHEMBL1614283 (1) CHEMBL1614211 (1)
0 / 0
P10636 Microtubule-associated protein tau Unclassified protein CHEMBL932 CHEMBL1614421 (7) CHEMBL1614502 (1)
4 / 3
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein CHEMBL932 CHEMBL1737980 (1) CHEMBL1738184 (1)
0 / 0
P10275 Androgen receptor NR3C4 CHEMBL932 CHEMBL924812 (1)
3 / 4
P23975 Sodium-dependent noradrenaline transporter Norepinephrine CHEMBL932 CHEMBL1909094 (2)
1 / 1
P25100 Alpha-1D adrenergic receptor Adrenergic receptor CHEMBL932 CHEMBL1909087 (2)
0 / 0
P30542 Adenosine receptor A1 Adenosine receptor CHEMBL932 CHEMBL1909213 (2)
0 / 0
P18089 Alpha-2B adrenergic receptor Adrenergic receptor CHEMBL932 CHEMBL1909089 (2)
0 / 0
P24557 Thromboxane-A synthase Cytochrome P450 5A1 CHEMBL932 CHEMBL1909116 (2)
1 / 1
Q9NP56 cAMP-specific 3',5'-cyclic phosphodiesterase 7B PDE_7B CHEMBL932 CHEMBL875201 (1) CHEMBL1629338 (1)
0 / 0
P06239 Tyrosine-protein kinase Lck Src CHEMBL932 CHEMBL1909206 (2)
0 / 1
O00408 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE_2A CHEMBL932 CHEMBL759916 (1) CHEMBL768899 (1)
CHEMBL762559 (1)
0 / 0
P25025 C-X-C chemokine receptor type 2 CXC chemokine receptor CHEMBL932 CHEMBL1909128 (2)
0 / 0
Q14145 Kelch-like ECH-associated protein 1 Unclassified protein CHEMBL932 CHEMBL2114882 (1)
0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme CHEMBL932 CHEMBL1613914 (5)
0 / 0
P40225 Thrombopoietin Unclassified protein CHEMBL932 CHEMBL1614086 (1) CHEMBL1614034 (1)
1 / 1
O00167 Eyes absent homolog 2 Enzyme CHEMBL932 CHEMBL1614315 (1)
0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme CHEMBL932 CHEMBL1738442 (4)
0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme CHEMBL932 CHEMBL1614364 (3)
1 / 1
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme CHEMBL932 CHEMBL1964002 (1) CHEMBL2354311 (1)
1 / 0
Q8IUX4 DNA dC->dU-editing enzyme APOBEC-3F Enzyme CHEMBL932 CHEMBL1963966 (1)
0 / 0
O15440 Multidrug resistance-associated protein 5 Unclassified protein CHEMBL932 CHEMBL2049558 (1) CHEMBL2049560 (1)
CHEMBL2077530 (1)
0 / 0
O00255 Menin Unclassified protein CHEMBL932 CHEMBL1614257 (1) CHEMBL1614531 (7)
2 / 5
Q08493 cAMP-specific 3',5'-cyclic phosphodiesterase 4C PDE_4C CHEMBL932 CHEMBL767079 (1)
0 / 0
Q07343 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE_4B CHEMBL932 CHEMBL767079 (1)
0 / 0
P27815 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE_4A CHEMBL932 CHEMBL767079 (1)
0 / 0
Q08499 cAMP-specific 3',5'-cyclic phosphodiesterase 4D PDE_4D CHEMBL932 CHEMBL767079 (1)
1 / 0
P18545 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE_6G CHEMBL932 CHEMBL830358 (1)
1 / 1
O43924 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta PDE_6D CHEMBL932 CHEMBL830358 (1)
0 / 0
P51160 Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' PDE_6C CHEMBL932 CHEMBL830358 (1)
1 / 1
Q13956 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE_6H CHEMBL932 CHEMBL830358 (1)
1 / 1
P16499 Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha PDE_6A CHEMBL932 CHEMBL830358 (1)
1 / 1
P35913 Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta PDE_6B CHEMBL932 CHEMBL830358 (1)
2 / 2
Q86TP1 Protein prune homolog Enzyme CHEMBL932 CHEMBL2091189 (1)
0 / 0
Q13370 cGMP-inhibited 3',5'-cyclic phosphodiesterase B PDE_3B CHEMBL932 CHEMBL871970 (1)
0 / 0
Q14432 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE_3A CHEMBL932 CHEMBL871970 (1)
0 / 0
Q14123 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C PDE_1C CHEMBL932 CHEMBL760664 (1) CHEMBL822069 (1)
0 / 0
P54750 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE_1A CHEMBL932 CHEMBL760664 (1) CHEMBL822069 (1)
0 / 0
Q01064 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE_1B CHEMBL932 CHEMBL760664 (1) CHEMBL822069 (1)
0 / 0
P07900 Heat shock protein HSP 90-alpha Other cytosolic protein CHEMBL932 CHEMBL1613874 (1)
0 / 0
P08238 Heat shock protein HSP 90-beta Other cytosolic protein CHEMBL932 CHEMBL1613874 (1)
0 / 0
Q9NY46 Sodium channel protein type 3 subunit alpha SCN alpha, NaV1.x CHEMBL932 CHEMBL806153 (1)
0 / 0
Q99250 Sodium channel protein type 2 subunit alpha SCN alpha, NaV1.x CHEMBL932 CHEMBL806153 (1)
2 / 2
P35498 Sodium channel protein type 1 subunit alpha SCN alpha, NaV1.x CHEMBL932 CHEMBL806153 (1)
3 / 2
Q13946 High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A PDE_7A CHEMBL932 CHEMBL875201 (1)
0 / 0
Q13148 TAR DNA-binding protein 43 Unclassified protein CHEMBL932 CHEMBL2354287 (1)
1 / 1

CTD interaction (63)

compound gene gene name gene description interaction interaction type form reference
pmid
D004176 10257 ABCC4
EST170205
MOAT-B
MOATB
MRP4
ATP-binding cassette, sub-family C (CFTR/MRP), member 4 Dipyridamole inhibits the reaction [ABCC4 protein results in increased transport of Cyclic GMP] decreases reaction
/ increases transport
protein 11856762
D004176 10257 ABCC4
EST170205
MOAT-B
MOATB
MRP4
ATP-binding cassette, sub-family C (CFTR/MRP), member 4 Dipyridamole results in decreased activity of ABCC4 protein decreases activity
protein 15827327
D004176 348 APOE
AD2
LDLCQ5
LPG
apolipoprotein E [Bezafibrate co-treated with Enalapril co-treated with Dipyridamole co-treated with atorvastatin co-treated with valsartan] results in decreased expression of APOE protein affects cotreatment
/ decreases expression
protein 19603250
D004176 598 BCL2L1
BCL-XL/S
BCL2L
BCLX
BCLXL
BCLXS
Bcl-X
PPP1R52
bcl-xL
bcl-xS
BCL2-like 1 Dipyridamole inhibits the reaction [Adenosine results in decreased expression of BCL2L1 mRNA] decreases expression
/ decreases reaction
mRNA 20063052
D004176 598 BCL2L1
BCL-XL/S
BCL2L
BCLX
BCLXL
BCLXS
Bcl-X
PPP1R52
bcl-xL
bcl-xS
BCL2-like 1 Dipyridamole inhibits the reaction [Adenosine results in decreased expression of BCL2L1 protein] decreases expression
/ decreases reaction
protein 20063052
D004176 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) Dipyridamole inhibits the reaction [Adenosine results in increased activity of CASP3 protein] decreases reaction
/ increases activity
protein 17303086
D004176 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) Dipyridamole results in increased activity of CASP3 protein increases activity
protein 22700542
D004176 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) Palmitic Acid promotes the reaction [Dipyridamole results in increased activity of CASP3 protein] increases activity
/ increases reaction
protein 22700542
D004176 840 CASP7
CASP-7
CMH-1
ICE-LAP3
LICE2
MCH3
caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) Dipyridamole results in increased activity of CASP7 protein increases activity
protein 22700542
D004176 840 CASP7
CASP-7
CMH-1
ICE-LAP3
LICE2
MCH3
caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) Palmitic Acid promotes the reaction [Dipyridamole results in increased activity of CASP7 protein] increases activity
/ increases reaction
protein 22700542
D004176 841 CASP8
ALPS2B
CAP4
Casp-8
FLICE
MACH
MCH5
caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) Dipyridamole inhibits the reaction [Adenosine results in increased activity of CASP8 protein] decreases reaction
/ increases activity
protein 17303086
D004176 959 CD40LG
CD154
CD40L
HIGM1
IGM
IMD3
T-BAM
TNFSF5
TRAP
gp39
hCD40L
CD40 ligand Dipyridamole results in decreased secretion of CD40LG protein decreases secretion
protein 16046616
D004176 8837 CFLAR
CASH
CASP8AP1
CLARP
Casper
FLAME
FLAME-1
FLAME1
FLIP
I-FLICE
MRIT
c-FLIP
c-FLIPL
c-FLIPR
c-FLIPS
CASP8 and FADD-like apoptosis regulator Dipyridamole inhibits the reaction [Adenosine results in decreased expression of CFLAR mRNA] decreases expression
/ decreases reaction
mRNA 17303086
D004176 8837 CFLAR
CASH
CASP8AP1
CLARP
Casper
FLAME
FLAME-1
FLAME1
FLIP
I-FLICE
MRIT
c-FLIP
c-FLIPL
c-FLIPR
c-FLIPS
CASP8 and FADD-like apoptosis regulator Dipyridamole inhibits the reaction [Adenosine results in decreased expression of CFLAR mRNA alternative form] decreases expression
/ decreases reaction
mRNA 17303086
D004176 8837 CFLAR
CASH
CASP8AP1
CLARP
Casper
FLAME
FLAME-1
FLAME1
FLIP
I-FLICE
MRIT
c-FLIP
c-FLIPL
c-FLIPR
c-FLIPS
CASP8 and FADD-like apoptosis regulator Dipyridamole inhibits the reaction [Adenosine results in decreased expression of CFLAR protein] decreases expression
/ decreases reaction
protein 17303086
D004176 1277 COL1A1
OI4
collagen, type I, alpha 1 Dipyridamole inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA] decreases reaction
/ increases expression
mRNA 11576339
D004176 1277 COL1A1
OI4
collagen, type I, alpha 1 N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Dipyridamole inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]] decreases reaction
/ increases expression
mRNA 11576339
D004176 1281 COL3A1
EDS4A
collagen, type III, alpha 1 Dipyridamole inhibits the reaction [TGFB1 protein results in increased expression of COL3A1 mRNA] decreases reaction
/ increases expression
mRNA 11576339
D004176 1281 COL3A1
EDS4A
collagen, type III, alpha 1 N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Dipyridamole inhibits the reaction [TGFB1 protein results in increased expression of COL3A1 mRNA]] decreases reaction
/ increases expression
mRNA 11576339
D004176 56616 DIABLO
DFNA64
SMAC
diablo, IAP-binding mitochondrial protein Dipyridamole inhibits the reaction [Adenosine results in increased expression of DIABLO mRNA] decreases reaction
/ increases expression
mRNA 20063052
D004176 56616 DIABLO
DFNA64
SMAC
diablo, IAP-binding mitochondrial protein Dipyridamole inhibits the reaction [Adenosine results in increased expression of DIABLO protein] decreases reaction
/ increases expression
protein 20063052
D004176 8772 FADD
MORT1
Fas (TNFRSF6)-associated via death domain Dipyridamole inhibits the reaction [Adenosine results in decreased expression of FADD mRNA] decreases expression
/ decreases reaction
mRNA 17303086
D004176 8772 FADD
MORT1
Fas (TNFRSF6)-associated via death domain Dipyridamole results in increased expression of FADD mRNA increases expression
mRNA 17303086
D004176 2353 FOS
AP-1
C-FOS
p55
FBJ murine osteosarcoma viral oncogene homolog Dipyridamole results in increased expression of FOS mRNA increases expression
mRNA 12730611
D004176 3553 IL1B
IL-1
IL1-BETA
IL1F2
interleukin 1, beta Dipyridamole promotes the reaction [8-bromocyclic GMP promotes the reaction [IL1B protein results in increased abundance of Nitrites]] increases abundance
/ increases reaction
protein 8904084
D004176 3553 IL1B
IL-1
IL1-BETA
IL1F2
interleukin 1, beta Dipyridamole promotes the reaction [Bucladesine promotes the reaction [IL1B protein results in increased abundance of Nitrites]] increases abundance
/ increases reaction
protein 8904084
D004176 3553 IL1B
IL-1
IL1-BETA
IL1F2
interleukin 1, beta Dipyridamole promotes the reaction [IL1B protein results in increased abundance of Cyclic AMP] increases abundance
/ increases reaction
protein 8904084
D004176 3553 IL1B
IL-1
IL1-BETA
IL1F2
interleukin 1, beta KT 5720 inhibits the reaction [Dipyridamole promotes the reaction [IL1B protein results in increased abundance of Cyclic AMP]] decreases reaction
/ increases abundance
/ increases reaction
protein 8904084
D004176 3553 IL1B
IL-1
IL1-BETA
IL1F2
interleukin 1, beta KT 5823 inhibits the reaction [Dipyridamole promotes the reaction [IL1B protein results in increased abundance of Cyclic AMP]] decreases reaction
/ increases abundance
/ increases reaction
protein 8904084
D004176 3643 INSR
CD220
HHF5
insulin receptor (EC:2.7.10.1) Dipyridamole inhibits the reaction [AICA ribonucleotide results in decreased activity of INSR promoter] decreases activity
/ decreases reaction
promoter 15694368
D004176 3643 INSR
CD220
HHF5
insulin receptor (EC:2.7.10.1) Dipyridamole inhibits the reaction [AICA ribonucleotide results in decreased expression of INSR mRNA] decreases expression
/ decreases reaction
mRNA 15694368
D004176 3643 INSR
CD220
HHF5
insulin receptor (EC:2.7.10.1) Dipyridamole inhibits the reaction [AICA ribonucleotide results in decreased expression of INSR protein] decreases expression
/ decreases reaction
protein 15694368
D004176 5599 MAPK8
JNK
JNK-46
JNK1
JNK1A2
JNK21B1/2
PRKM8
SAPK1
SAPK1c
mitogen-activated protein kinase 8 (EC:2.7.11.24) Dipyridamole results in increased activity of MAPK8 protein increases activity
protein 11051267
D004176 4879 NPPB
BNP
natriuretic peptide B Dipyridamole results in increased expression of NPPB protein increases expression
protein 18037770
D004176 5004 ORM1
AGP-A
AGP1
ORM
orosomucoid 1 Dipyridamole binds to ORM1 protein alternative form affects binding
protein 8946472
D004176 5004 ORM1
AGP-A
AGP1
ORM
orosomucoid 1 Dipyridamole inhibits the reaction [Warfarin binds to ORM1 protein alternative form] affects binding
/ decreases reaction
protein 8946472
D004176 5005 ORM2
AGP-B
AGP-B'
AGP2
orosomucoid 2 Dipyridamole inhibits the reaction [Imipramine binds to ORM2 protein alternative form] affects binding
/ decreases reaction
protein 8946472
D004176 10846 PDE10A
HSPDE10A
phosphodiesterase 10A (EC:3.1.4.35 3.1.4.17) Dipyridamole inhibits the reaction [PDE10A protein results in increased hydrolysis of Cyclic AMP] decreases reaction
/ increases hydrolysis
protein 10373451
D004176 10846 PDE10A
HSPDE10A
phosphodiesterase 10A (EC:3.1.4.35 3.1.4.17) Dipyridamole inhibits the reaction [PDE10A protein results in increased hydrolysis of Cyclic GMP] decreases reaction
/ increases hydrolysis
protein 10373451
D004176 50940 PDE11A
PPNAD2
phosphodiesterase 11A (EC:3.1.4.35 3.1.4.17) Dipyridamole inhibits the reaction [PDE11A protein results in increased hydrolysis of Cyclic GMP] decreases reaction
/ increases hydrolysis
protein 10725373
D004176 8654 PDE5A
CGB-PDE
CN5A
PDE5
phosphodiesterase 5A, cGMP-specific (EC:3.1.4.35) Dipyridamole results in decreased activity of PDE5A protein decreases activity
protein 11051267
D004176 5150 PDE7A
HCP1
PDE7
phosphodiesterase 7A (EC:3.1.4.17) Dipyridamole inhibits the reaction [PDE7A protein results in increased hydrolysis of Cyclic AMP] decreases reaction
/ increases hydrolysis
protein 10618442
D004176 27115 PDE7B
bA472E5.1
phosphodiesterase 7B (EC:3.1.4.17) Dipyridamole inhibits the reaction [PDE7B protein results in increased hydrolysis of Cyclic AMP] decreases reaction
/ increases hydrolysis
protein 10814504
10872825
D004176 5151 PDE8A
HsT19550
phosphodiesterase 8A (EC:3.1.4.17) Dipyridamole inhibits the reaction [PDE8A protein results in increased metabolism of Cyclic AMP] decreases reaction
/ increases metabolic processing
protein 12681444
D004176 8622 PDE8B
ADSD
PPNAD3
phosphodiesterase 8B (EC:3.1.4.17) Dipyridamole inhibits the reaction [PDE8B protein results in increased hydrolysis of Cyclic AMP] decreases reaction
/ increases hydrolysis
protein 9784418
D004176 8622 PDE8B
ADSD
PPNAD3
phosphodiesterase 8B (EC:3.1.4.17) Dipyridamole inhibits the reaction [PDE8B protein results in increased metabolism of Cyclic AMP] decreases reaction
/ increases metabolic processing
protein 12681444
D004176 5327 PLAT
T-PA
TPA
plasminogen activator, tissue (EC:3.4.21.68) Dipyridamole results in increased secretion of PLAT protein increases secretion
protein 15733978
D004176 5327 PLAT
T-PA
TPA
plasminogen activator, tissue (EC:3.4.21.68) KT 5823 inhibits the reaction [Dipyridamole results in increased secretion of PLAT protein] decreases reaction
/ increases secretion
protein 15733978
D004176 1827 RCAN1
ADAPT78
CSP1
DSC1
DSCR1
MCIP1
RCN1
regulator of calcineurin 1 Dipyridamole binds to RCAN1 protein alternative form affects binding
protein 19189965
D004176 2030 SLC29A1
ENT1
solute carrier family 29 (equilibrative nucleoside transporter), member 1 Dipyridamole inhibits the reaction [SLC29A1 protein results in increased uptake of Uridine] decreases reaction
/ increases uptake
protein 9353301
9396714
D004176 2030 SLC29A1
ENT1
solute carrier family 29 (equilibrative nucleoside transporter), member 1 Dipyridamole promotes the reaction [4-nitrobenzylthioinosine inhibits the reaction [[SLC29A1 protein co-treated with SLC29A2 protein] results in increased uptake of Uridine]] affects cotreatment
/ decreases reaction
/ increases reaction
/ increases uptake
protein 10366666
D004176 2030 SLC29A1
ENT1
solute carrier family 29 (equilibrative nucleoside transporter), member 1 Dipyridamole results in decreased activity of SLC29A1 protein decreases activity
protein 21678404
D004176 3177 SLC29A2
DER12
ENT2
HNP36
solute carrier family 29 (equilibrative nucleoside transporter), member 2 Dipyridamole promotes the reaction [4-nitrobenzylthioinosine inhibits the reaction [[SLC29A1 protein co-treated with SLC29A2 protein] results in increased uptake of Uridine]] affects cotreatment
/ decreases reaction
/ increases reaction
/ increases uptake
protein 10366666
D004176 6521 SLC4A1
AE1
BND3
CD233
DI
EMPB3
EPB3
FR
RTA1A
SW
WD
WD1
WR
solute carrier family 4 (anion exchanger), member 1 Dipyridamole inhibits the reaction [SLC4A1 protein results in increased transport of Chlorides] decreases reaction
/ increases transport
protein 2511191
D004176 7040 TGFB1
CED
DPD1
LAP
TGFB
TGFbeta
transforming growth factor, beta 1 Dipyridamole inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA] decreases reaction
/ increases expression
protein 11576339
D004176 7040 TGFB1
CED
DPD1
LAP
TGFB
TGFbeta
transforming growth factor, beta 1 Dipyridamole inhibits the reaction [TGFB1 protein results in increased expression of COL3A1 mRNA] decreases reaction
/ increases expression
protein 11576339
D004176 7040 TGFB1
CED
DPD1
LAP
TGFB
TGFbeta
transforming growth factor, beta 1 N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Dipyridamole inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]] decreases reaction
/ increases expression
protein 11576339
D004176 7040 TGFB1
CED
DPD1
LAP
TGFB
TGFbeta
transforming growth factor, beta 1 N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Dipyridamole inhibits the reaction [TGFB1 protein results in increased expression of COL3A1 mRNA]] decreases reaction
/ increases expression
protein 11576339
D004176 7422 VEGFA
MVCD1
VEGF
VPF
vascular endothelial growth factor A Adenosine promotes the reaction [Dipyridamole results in increased secretion of VEGFA protein] increases reaction
/ increases secretion
protein 20067761
D004176 7422 VEGFA
MVCD1
VEGF
VPF
vascular endothelial growth factor A Dipyridamole results in increased secretion of VEGFA protein increases secretion
protein 20067761
D004176 7422 VEGFA
MVCD1
VEGF
VPF
vascular endothelial growth factor A Heparitin Sulfate promotes the reaction [Dipyridamole results in increased secretion of VEGFA protein] increases reaction
/ increases secretion
protein 20067761
D004176 7422 VEGFA
MVCD1
VEGF
VPF
vascular endothelial growth factor A Hyaluronic Acid promotes the reaction [Dipyridamole results in increased secretion of VEGFA protein] increases reaction
/ increases secretion
protein 20067761
D004176 7422 VEGFA
MVCD1
VEGF
VPF
vascular endothelial growth factor A Lipopolysaccharides promotes the reaction [Dipyridamole results in increased secretion of VEGFA protein] increases reaction
/ increases secretion
protein 20067761

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (113)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#100100 Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism P20309
#614613 Acrodysostosis 2, with or without hormone resistance; acrdys2 Q08499
#103780 Alcohol dependence P08172
P14416
P31645
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#614373 Amyotrophic lateral sclerosis 16, juvenile; als16 Q99720
#300068 Androgen insensitivity syndrome; ais P10275
#312300 Androgen insensitivity, partial; pais P10275
#608584 Asthma-related traits, susceptibility to, 2 Q6W5P4
#208900 Ataxia-telangiectasia; at Q13315
#210900 Bloom syndrome; blm P54132
#602025 Body mass index quantitative trait locus 9; bmiq9 P41968
#114480 Breast cancer P38398
#604370 Breast-ovarian cancer, familial, susceptibility to, 1; brovca1 P38398
#300615 Brunner syndrome P21397
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#118300 Charcot-marie-tooth disease and deafness Q01453
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#118220 Charcot-marie-tooth disease, demyelinating, type 1a; cmt1a Q01453
#114500 Colorectal cancer; crc P84022
#613093 Cone dystrophy 4; cod4 P51160
#162800 Cyclic neutropenia P08246
#612522 Diabetes mellitus, insulin-dependent, 22; iddm22 P51681
#119900 Digital clubbing, isolated congenital P15428
#607208 Dravet syndrome P35498
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#237500 Dubin-johnson syndrome; djs Q92887
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#613721 Epileptic encephalopathy, early infantile, 11; eiee11 Q99250
#615363 Estrogen resistance; estrr P03372
#600274 Frontotemporal dementia; ftd P10636
#613659 Gastric cancer P04626
#137215 Gastric cancer, hereditary diffuse; hdgc P04626
#604403 Generalized epilepsy with febrile seizures plus, type 2; gefsp2 P35498
#231095 Ghosal hematodiaphyseal dysplasia; ghdd P24557
#137800 Glioma susceptibility 1; glm1 O75874
P04626
#232300 Glycogen storage disease ii P10253
#139393 Guillain-barre syndrome, familial; gbs Q01453
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#609423 Human immunodeficiency virus type 1, susceptibility to P41597
P51681
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#237450 Hyperbilirubinemia, rotor type; hblrr Q9NPD5
Q9Y6L6
#145000 Hyperparathyroidism 1; hrpt1 O00255
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#145900 Hypertrophic neuropathy of dejerine-sottas Q01453
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#612244 Inflammatory bowel disease 13; ibd13 P08183
#603932 Intervertebral disc disease; idd P14780
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#613688 Long qt syndrome 2; lqt2 Q12809
#211980 Lung cancer P00533
P04626
#608516 Major depressive disorder; mdd P08172
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#300705 Mental retardation, x-linked 17; mrx17 Q99714
%300852 Mental retardation, x-linked 88; mrx88 P50052
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#609634 Migraine, familial hemiplegic, 3; fhm3 P35498
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#126200 Multiple sclerosis, susceptibility to; ms P08575
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#159900 Myoclonic dystonia P14416
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#162500 Neuropathy, hereditary, with liability to pressure palsies; hnpp Q01453
#202700 Neutropenia, severe congenital, 1, autosomal dominant; scn1 P08246
#257200 Niemann-pick disease, type a P17405
#607616 Niemann-pick disease, type b P17405
#163500 Night blindness, congenital stationary, autosomal dominant 2; csnbad2 P35913
#601665 Obesity P32245
#164230 Obsessive-compulsive disorder; ocd P31645
#604715 Orthostatic intolerance P23975
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#167000 Ovarian cancer P04626
P38398
#614320 Pancreatic cancer, susceptibility to, 4; pnca4 P38398
#260540 Parkinson-dementia syndrome P10636
#613135 Parkinsonism-dystonia, infantile; pkdys Q01959
#172700 Pick disease of brain P10636
#610475 Pigmented nodular adrenocortical disease, primary, 2; ppnad2 Q9HCR9
#614190 Pigmented nodular adrenocortical disease, primary, 3; ppnad3 O95263
#607276 Resting heart rate, variation in P08588
#275210 Restrictive dermopathy, lethal P02545
#610024 Retinal cone dystrophy 3a; rcd3a Q13956
#613801 Retinitis pigmentosa 40; rp40 P35913
#613810 Retinitis pigmentosa 43; rp43 P16499
#613582 Retinitis pigmentosa 57; rp57 P18545
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#607745 Seizures, benign familial infantile, 3; bfis3 Q99250
#608971 Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive P08575
#609620 Short qt syndrome 1; sqt1 Q12809
#313200 Spinal and bulbar muscular atrophy, x-linked 1; smax1 P10275
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#609161 Striatal degeneration, autosomal dominant; adsd O95263
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#187950 Thrombocythemia 1; thcyt1 P40225
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828
#190300 Tremor, hereditary essential, 1; etm1 P35462
#610379 West nile virus, susceptibility to P51681
#112100 Yt blood group antigen P22303

KEGG DISEASE (83)

KEGG disease name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00260 Pigmented micronodular adrenocortical disease (PPNAD) O95263 (related)
Q9HCR9 (related)
H00016 Oral cancer P00533 (related)
P00533 (marker)
H00017 Esophageal cancer P00533 (related)
P35354 (related)
H00018 Gastric cancer P00533 (related)
P04626 (related)
H00022 Bladder cancer P00533 (related)
P04626 (related)
H00028 Choriocarcinoma P00533 (related)
P03956 (related)
P04626 (related)
H00030 Cervical cancer P00533 (related)
P04626 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
Q01453 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00026 Endometrial Cancer P03372 (marker)
P04626 (related)
Q92731 (marker)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00019 Pancreatic cancer P04626 (related)
H00027 Ovarian cancer P04626 (related)
P38398 (related)
H00031 Breast cancer P04626 (related)
P04626 (marker)
P38398 (related)
H00046 Cholangiocarcinoma P04626 (related)
P35354 (related)
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
H00079 Asthma P07550 (related)
H00100 Neutropenic disorders P08246 (related)
H00091 T-B+Severe combined immunodeficiencies (SCIDs) P08575 (related)
H00036 Osteosarcoma P08684 (marker)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00024 Prostate cancer P10275 (related)
H00062 Spinal and bulbar muscular atrophy (SBMA) P10275 (related)
H00608 46,XY disorders of sex development (Disorders in androgen synthesis or action) P10275 (related)
H00609 46,XY disorders of sex development (Other) P10275 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
Q13148 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H01205 Coumarin resistance P11712 (related)
H00025 Penile cancer P14780 (related)
P35354 (related)
H00479 Metaphyseal dysplasias P14780 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00527 Retinitis pigmentosa (RP) P16499 (related)
P18545 (related)
P35913 (related)
H00137 Niemann-Pick disease (NPD) typeA and B P17405 (related)
H00424 Defects in the degradation of sphingomyelin P17405 (related)
H00548 Brunner syndrome P21397 (related)
H01031 Orthostatic intolerance (OI) P23975 (related)
H00490 Diaphyseal dysplasia with anemia (Ghosal) P24557 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00775 Familial or sporadic hemiplegic migraine P35498 (related)
H00783 Febrile seizures P35498 (related)
H00787 Congenital stationary night blindness (CSNB) P35913 (related)
H00227 Congenital amegakaryocytic thrombocytopenia (CAMT) P40225 (marker)
H00480 Non-syndromic X-linked mental retardation P50052 (related)
Q99714 (related)
H00481 Cone-rod dystrophy and cone dystrophy P51160 (related)
Q13956 (related)
H00094 DNA repair defects P54132 (related)
Q13315 (related)
H00296 Defects in RecQ helicases P54132 (related)
H01296 Hereditary neuropathy with liability to pressure palsies (HNPP) Q01453 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00720 Long QT syndrome Q12809 (related)
H00725 Short QT syndrome Q12809 (related)
H00005 Chronic lymphocytic leukemia (CLL) Q13315 (related)
H00064 Ataxia telangiectasia (AT) Q13315 (related)
H00848 Ataxia with ocular apraxia (AOA) Q13315 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
Q16637 (related)
H00208 Hyperbilirubinemia Q92887 (related)
H00606 Early infantile epileptic encephalopathy Q99250 (related)
H00806 Benign familial neonatal and infantile epilepsies Q99250 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
Q9NUW8 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)

Diseases related to CTD interactions

77 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D015746 D004176 Abdominal Pain marker/mechanism
3815730
D000138 D004176 Acidosis therapeutic
1433833
D000544 D004176 Alzheimer Disease therapeutic
10222124
D000707 D004176 Anaphylaxis marker/mechanism
7977438
D000787 D004176 Angina Pectoris marker/mechanism
2061996
2093554
2323124
2370954
2384110
2399884
2408809
2521767
2714911
2766502
2950248
2965717
3343462
3630933
3859194
7075290
7087195
7752441
8015147
8026038
8044348
8331305
8379319
9112878
10511131
11481101
D000799 D004176 Angioedema marker/mechanism
7977438
D001002 D004176 Anuria marker/mechanism
3183852
D001049 D004176 Apnea marker/mechanism
8423863
D001145 D004176 Arrhythmias, Cardiac marker/mechanism
3812227
6193653
D001281 D004176 Atrial Fibrillation marker/mechanism
1464359
D054537 D004176 Atrioventricular Block marker/mechanism
463166
1422403
7814182
12049688
D001919 D004176 Bradycardia marker/mechanism
therapeutic
2365515
7906680
10221063
16595736
D001927 D004176 Brain Diseases marker/mechanism
7864009
D002545 D004176 Brain Ischemia marker/mechanism
7965160
D001986 D004176 Bronchial Spasm marker/mechanism
8412526
8423863
D002311 D004176 Cardiomyopathy, Dilated therapeutic
9665216
D002637 D004176 Chest Pain marker/mechanism
1941146
2107985
3812227
7728647
7864009
8254386
9420757
11948263
D002779 D004176 Cholestasis marker/mechanism
1360065
D003324 D004176 Coronary Artery Disease marker/mechanism
1736603
2283188
3783931
D003327 D004176 Coronary Disease marker/mechanism
463046
1743443
D003329 D004176 Coronary Vasospasm marker/mechanism
8175222
D003967 D004176 Diarrhea marker/mechanism
3815730
D004108 D004176 Dilatation, Pathologic marker/mechanism
2399884
D004244 D004176 Dizziness marker/mechanism
2107985
3812227
3812285
8254386
D004408 D004176 Dysgeusia marker/mechanism
4026910
D004409 D004176 Dyskinesia, Drug-Induced therapeutic
17377417
D004417 D004176 Dyspnea marker/mechanism
1941146
6193653
8412526
D005483 D004176 Flushing marker/mechanism
1395766
D042882 D004176 Gallstones marker/mechanism
1360065
7814819
9270928
10557571
D005767 D004176 Gastrointestinal Diseases marker/mechanism
1395766
18984426
D005921 D004176 Glomerulonephritis therapeutic
9496734
D006212 D004176 Hallucinations marker/mechanism
17845733
D006261 D004176 Headache marker/mechanism
78349
1395766
2107985
3812227
6193653
7738622
8254386
9781830
10594478
11525112
11948263
15452309
16788299
16886928
18984426
19289481
19521087
D006323 D004176 Heart Arrest marker/mechanism
3195884
3359832
7906680
8423863
8767777
9031766
19770528
D006327 D004176 Heart Block marker/mechanism
9922805
10221063
D006331 D004176 Heart Diseases therapeutic
983936
D006333 D004176 Heart Failure therapeutic
4026910
18037770
D006463 D004176 Hemolytic-Uremic Syndrome therapeutic
2413037
D006470 D004176 Hemorrhage marker/mechanism
therapeutic
1722991
18198244
D006940 D004176 Hyperemia marker/mechanism
1555293
1564236
2110037
2348231
2681325
2761383
3177197
6978059
7249300
7600651
7796497
8017281
8025998
8221859
8254386
8273756
8622587
8921787
8962555
9074535
9205015
9426021
9544659
9669263
9679717
10073812
10190876
10636254
10758630
11173779
11222474
11241807
11342469
11479248
11641194
11666096
11815423
12062733
12900738
15326083
15452468
15778950
16330034
17541306
17659557
18552138
19488826
19496111
D006973 D004176 Hypertension therapeutic
15127885
D006976 D004176 Hypertension, Pulmonary therapeutic
14583322
D007022 D004176 Hypotension marker/mechanism
therapeutic
1592228
1941146
2225669
2254563
3812285
7864009
8412526
8960082
9420757
9817684
16595736
D007174 D004176 Impulse Control Disorders marker/mechanism
6093179
D007431 D004176 Intraoperative Complications therapeutic
795299
8571641
8890804
D007511 D004176 Ischemia marker/mechanism
20145578
D002546 D004176 Ischemic Attack, Transient marker/mechanism
therapeutic
7864009
8326405
9287258
9781830
19521087
D007964 D004176 Leukocytosis marker/mechanism
1360065
D008881 D004176 Migraine Disorders marker/mechanism
16886928
D008944 D004176 Mitral Valve Insufficiency marker/mechanism
2738708
D009072 D004176 Moyamoya Disease therapeutic
16551458
D009203 D004176 Myocardial Infarction marker/mechanism
therapeutic
2323124
2800578
3359832
11765483
17043167
D017202 D004176 Myocardial Ischemia marker/mechanism
therapeutic
1515287
1830552
1898221
2039671
2084282
2107985
2321531
2330737
2370954
2389833
2437403
2620805
2707060
2738708
2795213
3257531
3343462
3437668
3677820
3746148
3812227
6193653
7074663
7161879
7498204
7618619
8013019
8252586
8368796
8837570
9109684
9359049
9482140
9562942
9649927
10084062
10660968
10892660
11286950
11391304
12036523
12167178
12586249
12766388
D017682 D004176 Myocardial Stunning marker/mechanism
11786737
D009325 D004176 Nausea marker/mechanism
3812227
6193653
8254386
8412526
11948263
D009369 D004176 Neoplasms therapeutic
3815730
D009401 D004176 Nephrosis therapeutic
9824428
D010146 D004176 Pain marker/mechanism
8412526
9619318
D010292 D004176 Paresthesia marker/mechanism
8412526
D056627 D004176 Peritoneal Fibrosis therapeutic
11380836
D020795 D004176 Photophobia marker/mechanism
16886928
D011507 D004176 Proteinuria therapeutic
1744988
D015427 D004176 Reperfusion Injury therapeutic
16003293
D012770 D004176 Shock, Cardiogenic marker/mechanism
15944542
D054138 D004176 Sinus Arrest, Cardiac marker/mechanism
8306773
D020521 D004176 Stroke marker/mechanism
therapeutic
8326405
8418253
9287258
9781830
11452896
16211203
16382298
16788299
17046050
17845733
19521087
D013345 D004176 Subarachnoid Hemorrhage marker/mechanism
1886315
20345728
D013375 D004176 Substance Withdrawal Syndrome therapeutic
9576224
14583322
D013575 D004176 Syncope marker/mechanism
8254386
D017180 D004176 Tachycardia, Ventricular marker/mechanism
1898221
8175222
10820963
D054549 D004176 Takotsubo Cardiomyopathy marker/mechanism
20340053
D013927 D004176 Thrombosis therapeutic
3496060
16382298
D020246 D004176 VENOUS THROMBOSIS therapeutic
795299
D018487 D004176 Ventricular Dysfunction, Left marker/mechanism
therapeutic
1736611
1743443
2399884
8571641
8890804
8970418
9665216
11872684
D018879 D004176 Ventricular Premature Complexes marker/mechanism
463166
9491948
D014717 D004176 Vertigo therapeutic
2651175
D014839 D004176 Vomiting marker/mechanism
8412526