PCIDB

Coronilla valentina

Species

KNApSAcK Entry

Organism name Coronilla valentina
Genus Coronilla
Family Fabaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Coronilla valentina
Linked NCBI taxonomy ID 118893
Linked level species

Family

Family in NCBI taxonomy Fabaceae
ID 3803

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class rosids
ID 71275

Metabolite list (6)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		KCF-S
cluster 		phytochemical
cluster 		figure
C00005719 External link 512 Limocitrin 3-rutinoside
No. 1 No. 15
C00005709 External link 512 Haplogenin 3-rutinoside
No. 1 No. 15
C00004725 External link 512 Haplogenin
No. 3 No. 15
C00004731 External link 512 Limocitrin
CHEMBL452488
No. 3 No. 15
C00002503 External link 512 Umbelliferon
/ Umbelliferone
/ 7-Hydroxycoumarin
CHEMBL51628
C031477
39 / 33 / 32 9 / 0 No. 1030 No. 25
C00000297 External link 512 Psoralen
CHEMBL164660
D005363
12 / 6 / 6 0 / 5 No. 1282 No. 25

Human Protein / Gene in interactions

47 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P83916 Chromobox protein homolog 1 Unclassified protein C00000297 C00002503 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00000297 C00002503 0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00000297 C00002503 3 / 3
P56817 Beta-secretase 1 A1A C00000297 C00002503 0 / 0
P15121 Aldose reductase Enzyme C00002503 0 / 0
P04062 Glucosylceramidase Enzyme C00002503 6 / 4
P10253 Lysosomal alpha-glucosidase Hydrolase C00002503 1 / 1
P29466 Caspase-1 C14 C00002503 0 / 0
P04406 Glyceraldehyde-3-phosphate dehydrogenase Enzyme C00002503 0 / 0
P20813 Cytochrome P450 2B6 Cytochrome P450 2B6 C00000297 1 / 0
P47989 Xanthine dehydrogenase/oxidase Oxidoreductase C00002503 1 / 1
P00918 Carbonic anhydrase 2 Lyase C00002503 1 / 2
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00000297 0 / 1
P11388 DNA topoisomerase 2-alpha Isomerase C00000297 0 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00002503 0 / 0
P28845 Corticosteroid 11-beta-dehydrogenase isozyme 1 Enzyme C00002503 1 / 1
O43570 Carbonic anhydrase 12 Lyase C00002503 1 / 2
P11509 Cytochrome P450 2A6 Cytochrome P450 2A6 C00000297 0 / 0
P39748 Flap endonuclease 1 Enzyme C00002503 0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme C00002503 0 / 0
O75496 Geminin Unclassified protein C00002503 0 / 0
P54855 UDP-glucuronosyltransferase 2B15 Enzyme C00002503 0 / 0
P18405 3-oxo-5-alpha-steroid 4-dehydrogenase 1 Oxidoreductase C00002503 0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00002503 0 / 3
P00915 Carbonic anhydrase 1 Lyase C00002503 0 / 0
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00000297 1 / 0
P14679 Tyrosinase Oxidoreductase C00002503 4 / 2
P06280 Alpha-galactosidase A Enzyme C00002503 1 / 1
Q99700 Ataxin-2 Unclassified protein C00002503 1 / 1
Q16790 Carbonic anhydrase 9 Lyase C00002503 0 / 1
Q9HAW8 UDP-glucuronosyltransferase 1-10 Enzyme C00002503 0 / 0
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00002503 2 / 2
Q9HAW9 UDP-glucuronosyltransferase 1-8 Enzyme C00002503 0 / 0
Q9Y4X1 UDP-glucuronosyltransferase 2A1 Enzyme C00002503 0 / 0
P22303 Acetylcholinesterase Hydrolase C00002503 1 / 0
Q00796 Sorbitol dehydrogenase Enzyme C00002503 0 / 0
P19838 Nuclear factor NF-kappa-B p105 subunit Transcription Factor C00000297 0 / 0
P55210 Caspase-7 C14 C00002503 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00000297 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00000297 0 / 1
P22309 UDP-glucuronosyltransferase 1-1 Enzyme C00002503 5 / 1
P80365 Corticosteroid 11-beta-dehydrogenase isozyme 2 Enzyme C00002503 1 / 1
P22310 UDP-glucuronosyltransferase 1-4 Enzyme C00002503 3 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00002503 1 / 1
O00255 Menin Unclassified protein C00002503 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00002503 1 / 2
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00002503 0 / 0

9 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
8644 AKR1C3, DD3, DDX, HA1753, HAKRB, HAKRe, HSD17B5, PGFS, hluPGFS aldo-keto reductase family 1, member C3 (EC:1.3.1.20 1.1.1.188 1.1.1.239 1.1.1.64 1.1.1.112 1.1.1.357) C00002503
8574 AKR7A2, AFAR, AFAR1, AFB1-AR1, AKR7 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) (EC:1.1.1.n11) C00002503
581 BAX, BCL2L4 BCL2-associated X protein C00002503
596 BCL2, Bcl-2, PPP1R50 B-cell CLL/lymphoma 2 C00002503
595 CCND1, BCL1, D11S287E, PRAD1, U21B31 cyclin D1 C00002503
1548 CYP2A6, CPA6, CYP2A, CYP2A3, CYPIIA6, P450C2A, P450PB cytochrome P450, family 2, subfamily A, polypeptide 6 (EC:1.14.14.1) C00002503
6817 SULT1A1, HAST1/HAST2, P-PST, PST, ST1A1, ST1A3, STP, STP1, TSPST1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 (EC:2.8.2.1) C00002503
54600 UGT1A9, HLUGP4, LUGP4, UDPGT, UDPGT_1-9, UGT-1I, UGT1-09, UGT1-9, UGT1.9, UGT1AI, UGT1I UDP glucuronosyltransferase 1 family, polypeptide A9 (EC:2.4.1.17) C00002503
7366 UGT2B15, HLUG4, UDPGT_2B8, UDPGT2B15, UDPGTH3, UGT2B8 UDP glucuronosyltransferase 2 family, polypeptide B15 (EC:2.4.1.17) C00002503

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (36)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#103470 Albinism, ocular, with sensorineural deafness P14679
#203100 Albinism, oculocutaneous, type ia; oca1a P14679
#606952 Albinism, oculocutaneous, type ib; oca1b P14679
#218030 Apparent mineralocorticoid excess; ame P80365
#601816 Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 P22309
#604931 Cortisone reductase deficiency 1; cortrd1 P28845
#218800 Crigler-najjar syndrome, type i P22309
P22310
#606785 Crigler-najjar syndrome, type ii P22309
P22310
#119900 Digital clubbing, isolated congenital P15428
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#614546 Efavirenz, poor metabolism of P20813
#301500 Fabry disease P06280
#608013 Gaucher disease, perinatal lethal P04062
#230800 Gaucher disease, type i P04062
#230900 Gaucher disease, type ii P04062
#231000 Gaucher disease, type iii P04062
#231005 Gaucher disease, type iiic P04062
#143500 Gilbert syndrome P22309
P22310
#232300 Glycogen storage disease ii P10253
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#237900 Hyperbilirubinemia, transient familial neonatal; hblrtfn P22309
#143860 Hyperchlorhidrosis, isolated O43570
#145000 Hyperparathyroidism 1; hrpt1 O00255
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#168600 Parkinson disease, late-onset; pd P04062
#601800 Skin/hair/eye pigmentation, variation in, 3; shep3 P14679
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#278300 Xanthinuria, type i P47989
#112100 Yt blood group antigen P22303

KEGG DISEASE (35)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H01302 Hyperchlorhidrosis isolated (HCHLH) O43570 (related)
H00021 Renal cell carcinoma O43570 (marker)
Q16790 (marker)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00066 Lewy body dementia (LBD) P04062 (related)
H00126 Gaucher disease P04062 (related)
H00426 Defects in the degradation of ganglioside P04062 (related)
H00810 Progressive myoclonic epilepsy (PME) P04062 (related)
H00125 Fabry disease P06280 (related)
H00036 Osteosarcoma P08684 (marker)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H01205 Coumarin resistance P11712 (related)
H00168 Oculocutaneous albinism (OCA) P14679 (related)
H00038 Malignant melanoma P14679 (marker)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00208 Hyperbilirubinemia P22309 (related)
H01111 Cortisone reductase deficiency (CRD) P28845 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00017 Esophageal cancer P35354 (related)
H00025 Penile cancer P35354 (related)
H00046 Cholangiocarcinoma P35354 (related)
H00192 Xanthinuria P47989 (related)
H00259 Apparent mineralocorticoid excess syndrome P80365 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
Q9NUW8 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)

Diseases related to CTD interactions

5 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D000647 Amnesia C00000297
D002280 Carcinoma, Basal Cell C00000297
D017484 Dermatitis, Phototoxic C00000297
D056486 Drug-Induced Liver Injury C00000297
D011565 Psoriasis C00000297