KNApSAcK Metabolite C00001539
Metabolite
KNApSAcK Entry
| id | C00001539 |
|---|---|
| Name | Folic acid |
| CAS RN | 59-30-3 |
| Standard InChI | InChI=1S/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s1 |
| Standard InChI (Main Layer) | InChI=1S/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30) |
Cluster
| Phytochemical cluster | |
|---|---|
| KCF-S cluster | No. 1399 |
Link
ChEMBL
| By standard InChI | CHEMBL1622 |
|---|---|
| By standard InChI Main Layer | CHEMBL277040 CHEMBL1622 |
KEGG
| By LinkDB | C00504 |
|---|
CTD
| By CAS RN | D005492 |
|---|
Species
Summary
Plant class
| class name | count |
|---|---|
| eudicotyledons | 1 |
Family
| family name | count |
|---|---|
| Amaranthaceae | 1 |
List (1)
* NCBI
| KNApSAcK organism | *ID | *family | *plant class | *kingdom |
|---|---|---|---|---|
| Spinacia oleracea | 3562 | Amaranthaceae | eudicotyledons | Viridiplantae |
Human Protein / Gene in interaction
34 ChEMBL Protein in interactions
| accession | description | class description | compound | assay ID (# of activities) |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|---|
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | CHEMBL1622 |
CHEMBL1741321
(1)
|
1 / 0 |
| P06746 | DNA polymerase beta | Enzyme | CHEMBL1622 |
CHEMBL1614079
(1)
|
0 / 0 |
| P04062 | Glucosylceramidase | Enzyme | CHEMBL1622 |
CHEMBL1613818
(1)
|
6 / 4 |
| P10253 | Lysosomal alpha-glucosidase | Hydrolase | CHEMBL1622 |
CHEMBL1614076
(1)
|
1 / 1 |
| O15245 | Solute carrier family 22 member 1 | Drug uniporter | CHEMBL1622 |
CHEMBL993349
(1)
|
0 / 0 |
| P37840 | Alpha-synuclein | Unclassified protein | CHEMBL1622 |
CHEMBL2354282
(1)
|
4 / 2 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | CHEMBL1622 |
CHEMBL1614361
(1)
|
3 / 2 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | CHEMBL1622 |
CHEMBL1741325
(1)
|
0 / 1 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | CHEMBL1622 |
CHEMBL1614458
(1)
|
0 / 0 |
| P17405 | Sphingomyelin phosphodiesterase | Enzyme | CHEMBL1622 |
CHEMBL1794495
(1)
|
2 / 2 |
| P84022 | Mothers against decapentaplegic homolog 3 | Unclassified protein | CHEMBL277040 |
CHEMBL1794584
(1)
|
2 / 0 |
| O75496 | Geminin | Unclassified protein | CHEMBL277040 |
CHEMBL2114780
(1)
|
0 / 0 |
| O15439 | Multidrug resistance-associated protein 4 | Unclassified protein | CHEMBL1622 |
CHEMBL2075982
(1)
CHEMBL2078617
(1)
CHEMBL2078635 (1) |
0 / 0 |
| Q05932 | Folylpolyglutamate synthase, mitochondrial | Enzyme | CHEMBL1622 |
CHEMBL678794
(1)
CHEMBL678885
(1)
|
0 / 0 |
| P43220 | Glucagon-like peptide 1 receptor | Glucagon-like peptide receptor | CHEMBL1622 |
CHEMBL2114788
(1)
|
0 / 0 |
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | CHEMBL1622 |
CHEMBL1794467
(1)
|
0 / 0 |
| P04818 | Thymidylate synthase | Transferase | CHEMBL1622 |
CHEMBL809254
(1)
CHEMBL815565
(1)
|
0 / 0 |
| P06280 | Alpha-galactosidase A | Enzyme | CHEMBL277040 CHEMBL1622 |
CHEMBL1614217
(1)
CHEMBL1614369
(1)
|
1 / 1 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | CHEMBL1622 |
CHEMBL1741322
(1)
|
0 / 0 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | CHEMBL1622 |
CHEMBL1613910
(2)
|
3 / 3 |
| Q9UNQ0 | ATP-binding cassette sub-family G member 2 | ATP binding cassette | CHEMBL1622 |
CHEMBL2077075
(1)
|
2 / 0 |
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | CHEMBL277040 CHEMBL1622 |
CHEMBL1614038
(2)
|
2 / 2 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | CHEMBL1622 |
CHEMBL1741323
(1)
|
1 / 1 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | CHEMBL1622 |
CHEMBL1741324
(1)
|
0 / 1 |
| Q9UNA4 | DNA polymerase iota | Enzyme | CHEMBL277040 |
CHEMBL1794483
(1)
|
0 / 0 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | CHEMBL1622 |
CHEMBL1614211
(1)
|
0 / 0 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | CHEMBL1622 |
CHEMBL1738184
(1)
|
0 / 0 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | CHEMBL277040 |
CHEMBL1794536
(1)
|
0 / 0 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | CHEMBL1622 |
CHEMBL1613914
(2)
|
0 / 0 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | CHEMBL1622 |
CHEMBL1614364
(1)
|
1 / 1 |
| O00255 | Menin | Unclassified protein | CHEMBL1622 |
CHEMBL1614531
(1)
|
2 / 5 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | CHEMBL1622 |
CHEMBL1614531
(1)
|
1 / 3 |
| Q96QA9 | Multidrug resistance associated protein | Unclassified protein | CHEMBL1622 |
CHEMBL2076878
(1)
|
0 / 0 |
| Q96J66 | ATP-binding cassette sub-family C member 11 | Unclassified protein | CHEMBL1622 |
CHEMBL2076056
(1)
|
1 / 0 |
CTD interaction (234)
| compound | gene | gene name | gene description | interaction | interaction type | form |
reference
pmid |
|---|---|---|---|---|---|---|---|
| D005492 | 4363 |
ABCC1
ABC29 ABCC GS-X MRP MRP1 |
ATP-binding cassette, sub-family C (CFTR/MRP), member 1 | Folic Acid affects the activity of ABCC1 protein |
affects activity
|
protein |
15041471
|
| D005492 | 4363 |
ABCC1
ABC29 ABCC GS-X MRP MRP1 |
ATP-binding cassette, sub-family C (CFTR/MRP), member 1 | Folic Acid affects the expression of ABCC1 protein |
affects expression
|
protein |
15657365
|
| D005492 | 4363 |
ABCC1
ABC29 ABCC GS-X MRP MRP1 |
ATP-binding cassette, sub-family C (CFTR/MRP), member 1 | Folic Acid deficiency inhibits the reaction [ABCC1 protein results in increased secretion of Daunorubicin] |
decreases reaction
/ increases secretion |
protein |
15041471
|
| D005492 | 9429 |
ABCG2
ABC15 ABCP BCRP BCRP1 BMDP CD338 CDw338 EST157481 GOUT1 MRX MXR MXR1 UAQTL1 |
ATP-binding cassette, sub-family G (WHITE), member 2 | ABCG2 protein affects the transport of Folic Acid |
affects transport
|
protein |
17032904
|
| D005492 | 9429 |
ABCG2
ABC15 ABCP BCRP BCRP1 BMDP CD338 CDw338 EST157481 GOUT1 MRX MXR MXR1 UAQTL1 |
ATP-binding cassette, sub-family G (WHITE), member 2 | Folic Acid affects the localization of and affects the expression of ABCG2 protein |
affects expression
/ affects localization |
protein |
15657365
|
| D005492 | 9429 |
ABCG2
ABC15 ABCP BCRP BCRP1 BMDP CD338 CDw338 EST157481 GOUT1 MRX MXR MXR1 UAQTL1 |
ATP-binding cassette, sub-family G (WHITE), member 2 | Protons promotes the reaction [ABCG2 protein results in increased transport of Folic Acid] |
increases reaction
/ increases transport |
protein |
17032904
|
| D005492 | 43 |
ACHE
ACEE ARACHE N-ACHE YT |
acetylcholinesterase (EC:3.1.1.7) | Folic Acid inhibits the reaction [MTHFR gene polymorphism results in increased activity of ACHE protein] |
decreases reaction
/ increases activity |
protein |
16375580
|
| D005492 | 57007 |
ACKR3
CMKOR1 CXC-R7 CXCR-7 CXCR7 GPR159 RDC-1 RDC1 |
atypical chemokine receptor 3 | Folic Acid affects the expression of ACKR3 mRNA |
affects expression
|
mRNA |
17320366
|
| D005492 | 51554 |
ACKR4
CC-CKR-11 CCBP2 CCR-11 CCR10 CCR11 CCRL1 CCX_CKR CCX-CKR CKR-11 PPR1 VSHK1 |
atypical chemokine receptor 4 | Folic Acid affects the expression of ACKR4 mRNA |
affects expression
|
mRNA |
17320366
|
| D005492 | 59 |
ACTA2
AAT6 ACTSA MYMY5 |
actin, alpha 2, smooth muscle, aorta | Folic Acid affects the expression of ACTA2 mRNA |
affects expression
|
mRNA |
17320366
|
| D005492 | 70 |
ACTC1
ACTC ASD5 CMD1R CMH11 LVNC4 |
actin, alpha, cardiac muscle 1 | Folic Acid affects the expression of ACTC1 mRNA |
affects expression
|
mRNA |
17320366
|
| D005492 | 60312 |
AFAP1
AFAP AFAP-110 AFAP110 |
actin filament associated protein 1 | Folic Acid affects the expression of AFAP1 mRNA |
affects expression
|
mRNA |
17320366
|
| D005492 | 10551 |
AGR2
AG2 GOB-4 HAG-2 PDIA17 XAG-2 |
anterior gradient 2 | Folic Acid results in increased expression of AGR2 mRNA |
increases expression
|
mRNA |
17868486
|
| D005492 | 205 |
AK4
AK_4 AK3 AK3L1 AK3L2 |
adenylate kinase 4 (EC:2.7.4.10 2.7.4.6) | Folic Acid affects the expression of AK4 mRNA |
affects expression
|
mRNA |
17320366
|
| D005492 | 9590 |
AKAP12
AKAP250 SSeCKS |
A kinase (PRKA) anchor protein 12 | Folic Acid results in decreased expression of AKAP12 mRNA |
decreases expression
|
mRNA |
11723236
|
| D005492 | 213 |
ALB
PRO0883 PRO0903 PRO1341 |
albumin | ALB protein binds to Folic Acid |
affects binding
|
protein |
17029005
|
| D005492 | 216 |
ALDH1A1
ALDC ALDH-E1 ALDH1 ALDH11 PUMB1 RALDH1 |
aldehyde dehydrogenase 1 family, member A1 (EC:1.2.1.36) | Folic Acid affects the expression of ALDH1A1 mRNA |
affects expression
|
mRNA |
17868486
|
| D005492 | 10840 |
ALDH1L1
10-FTHFDH 10-fTHF FDH FTHFD |
aldehyde dehydrogenase 1 family, member L1 (EC:1.5.1.6) | ALDH1L1 protein results in increased degradation of Folic Acid |
increases degradation
|
protein |
16627483
|
| D005492 | 27063 |
ANKRD1
ALRP C-193 CARP CVARP MCARP bA320F15.2 |
ankyrin repeat domain 1 (cardiac muscle) | Folic Acid results in increased expression of ANKRD1 mRNA |
increases expression
|
mRNA |
17868486
|
| D005492 | 312 |
ANXA13
ANX13 ISA |
annexin A13 | Folic Acid affects the expression of ANXA13 mRNA |
affects expression
|
mRNA |
17868486
|
| D005492 | 338 |
APOB
FLDB LDLCQ4 |
apolipoprotein B | [Eicosapentaenoic Acid co-treated with Docosahexaenoic Acids co-treated with Oleic Acid co-treated with Folic Acid co-treated with Vitamin B 6 co-treated with Vitamin E] results in decreased expression of APOB protein |
affects cotreatment
/ decreases expression |
protein |
17237316
|
| D005492 | 338 |
APOB
FLDB LDLCQ4 |
apolipoprotein B | Folic Acid results in increased expression of APOB mRNA |
increases expression
|
mRNA |
17868486
|
| D005492 | 9411 |
ARHGAP29
PARG1 RP11-255E17.1 |
Rho GTPase activating protein 29 | Folic Acid affects the expression of ARHGAP29 mRNA |
affects expression
|
mRNA |
17320366
|
| D005492 | 10123 |
ARL4C
ARL7 LAK |
ADP-ribosylation factor-like 4C | Folic Acid affects the expression of ARL4C mRNA |
affects expression
|
mRNA |
17320366
|
| D005492 | 57412 |
AS3MT
CYT19 |
arsenic (+3 oxidation state) methyltransferase (EC:2.1.1.137) | Folic Acid promotes the reaction [Vitamin B 12 promotes the reaction [AS3MT protein results in increased methylation of Arsenic]] |
increases methylation
/ increases reaction |
protein |
20049124
|
| D005492 | 1388 |
ATF6B
CREB-RP CREBL1 G13 |
activating transcription factor 6 beta | Folic Acid affects the expression of ATF6B mRNA |
affects expression
|
mRNA |
17320366
|
| D005492 | 472 |
ATM
AT1 ATA ATC ATD ATDC ATE TEL1 TELO1 |
ataxia telangiectasia mutated (EC:2.7.11.1) | Folic Acid affects the expression of ATM mRNA |
affects expression
|
mRNA |
16361273
|
| D005492 | 567 |
B2M
|
beta-2-microglobulin | Folic Acid affects the expression of B2M mRNA |
affects expression
|
mRNA |
17868486
|
| D005492 | 581 |
BAX
BCL2L4 |
BCL2-associated X protein | Folic Acid affects the expression of BAX mRNA |
affects expression
|
mRNA |
16361273
|
| D005492 | 596 |
BCL2
Bcl-2 PPP1R50 |
B-cell CLL/lymphoma 2 | Folic Acid affects the expression of BCL2 mRNA |
affects expression
|
mRNA |
16611376
|
| D005492 | 10018 |
BCL2L11
BAM BIM BOD |
BCL2-like 11 (apoptosis facilitator) | Folic Acid affects the expression of BCL2L11 mRNA |
affects expression
|
mRNA |
16361273
|
| D005492 | 51283 |
BFAR
BAR RNF47 |
bifunctional apoptosis regulator | Folic Acid affects the expression of BFAR mRNA |
affects expression
|
mRNA |
16361273
|
| D005492 | 329 |
BIRC2
API1 HIAP2 Hiap-2 MIHB RNF48 c-IAP1 cIAP1 |
baculoviral IAP repeat containing 2 | Folic Acid results in increased expression of BIRC2 mRNA |
increases expression
|
mRNA |
15211800
|
| D005492 | 329 |
BIRC2
API1 HIAP2 Hiap-2 MIHB RNF48 c-IAP1 cIAP1 |
baculoviral IAP repeat containing 2 | Folic Acid results in increased expression of BIRC2 protein |
increases expression
|
protein |
15211800
|
| D005492 | 330 |
BIRC3
AIP1 API2 CIAP2 HAIP1 HIAP1 MALT2 MIHC RNF49 c-IAP2 |
baculoviral IAP repeat containing 3 | Folic Acid affects the expression of BIRC3 mRNA |
affects expression
|
mRNA |
16361273
|
| D005492 | 664 |
BNIP3
NIP3 |
BCL2/adenovirus E1B 19kDa interacting protein 3 | Folic Acid affects the expression of BNIP3 mRNA |
affects expression
|
mRNA |
17320366
|
| D005492 | 665 |
BNIP3L
BNIP3a NIX |
BCL2/adenovirus E1B 19kDa interacting protein 3-like | Folic Acid affects the expression of BNIP3L mRNA |
affects expression
|
mRNA |
17320366
|
| D005492 | 837 |
CASP4
ICE(rel)II ICEREL-II ICH-2 Mih1/TX TX |
caspase 4, apoptosis-related cysteine peptidase (EC:3.4.22.57) | Folic Acid affects the expression of CASP4 mRNA |
affects expression
|
mRNA |
16361273
|
| D005492 | 839 |
CASP6
MCH2 |
caspase 6, apoptosis-related cysteine peptidase (EC:3.4.22.59) | Folic Acid affects the expression of CASP6 mRNA |
affects expression
|
mRNA |
16361273
|
| D005492 | 841 |
CASP8
ALPS2B CAP4 Casp-8 FLICE MACH MCH5 |
caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) | Folic Acid affects the expression of CASP8 mRNA |
affects expression
|
mRNA |
16361273
|
| D005492 | 6347 |
CCL2
GDCF-2 HC11 HSMCR30 MCAF MCP-1 MCP1 SCYA2 SMC-CF |
chemokine (C-C motif) ligand 2 | Folic Acid inhibits the reaction [Homocysteine results in increased expression of CCL2 mRNA] |
decreases reaction
/ increases expression |
mRNA |
16845898
|
| D005492 | 6347 |
CCL2
GDCF-2 HC11 HSMCR30 MCAF MCP-1 MCP1 SCYA2 SMC-CF |
chemokine (C-C motif) ligand 2 | Folic Acid results in decreased expression of CCL2 protein |
decreases expression
|
protein |
16491109
|
| D005492 | 595 |
CCND1
BCL1 D11S287E PRAD1 U21B31 |
cyclin D1 | Folic Acid affects the expression of CCND1 mRNA |
affects expression
|
mRNA |
16361273
|
| D005492 | 896 |
CCND3
|
cyclin D3 | Folic Acid results in decreased expression of CCND3 mRNA |
decreases expression
|
mRNA |
11723236
|
| D005492 | 898 |
CCNE1
CCNE |
cyclin E1 | Folic Acid affects the expression of CCNE1 mRNA |
affects expression
|
mRNA |
16361273
|
| D005492 | 999 |
CDH1
Arc-1 CD324 CDHE ECAD LCAM UVO |
cadherin 1, type 1, E-cadherin (epithelial) | Folic Acid results in decreased expression of CDH1 protein |
decreases expression
|
protein |
17868486
|
| D005492 | 1012 |
CDH13
CDHH P105 |
cadherin 13 (EC:3.6.1.3) | Folic Acid results in decreased expression of CDH13 mRNA |
decreases expression
|
mRNA |
11723236
|
| D005492 | 1001 |
CDH3
CDHP HJMD PCAD |
cadherin 3, type 1, P-cadherin (placental) | Folic Acid results in increased expression of CDH3 mRNA |
increases expression
|
mRNA |
17868486
|
| D005492 | 1026 |
CDKN1A
CAP20 CDKN1 CIP1 MDA-6 P21 SDI1 WAF1 p21CIP1 |
cyclin-dependent kinase inhibitor 1A (p21, Cip1) | Folic Acid affects the expression of CDKN1A mRNA |
affects expression
|
mRNA |
16361273
|
| D005492 | 1026 |
CDKN1A
CAP20 CDKN1 CIP1 MDA-6 P21 SDI1 WAF1 p21CIP1 |
cyclin-dependent kinase inhibitor 1A (p21, Cip1) | Folic Acid affects the expression of CDKN1A protein |
affects expression
|
protein |
16361273
|
| D005492 | 1027 |
CDKN1B
CDKN4 KIP1 MEN1B MEN4 P27KIP1 |
cyclin-dependent kinase inhibitor 1B (p27, Kip1) | Folic Acid affects the expression of CDKN1B mRNA |
affects expression
|
mRNA |
16361273
|
| D005492 | 1029 |
CDKN2A
ARF CDK4I CDKN2 CMM2 INK4 INK4A MLM MTS-1 MTS1 P14 P14ARF P16 P16-INK4A P16INK4 P16INK4A P19 P19ARF TP16 |
cyclin-dependent kinase inhibitor 2A | Folic Acid affects the methylation of CDKN2A promoter |
affects methylation
|
promoter |
16646054
|
| D005492 | 1029 |
CDKN2A
ARF CDK4I CDKN2 CMM2 INK4 INK4A MLM MTS-1 MTS1 P14 P14ARF P16 P16-INK4A P16INK4 P16INK4A P19 P19ARF TP16 |
cyclin-dependent kinase inhibitor 2A | MTHFR gene polymorphism affects the reaction [Folic Acid affects the methylation of CDKN2A promoter] |
affects methylation
/ affects reaction |
promoter |
16646054
|
| D005492 | 1111 |
CHEK1
CHK1 |
checkpoint kinase 1 (EC:2.7.11.1) | Folic Acid affects the expression of CHEK1 mRNA |
affects expression
|
mRNA |
16361273
|
| D005492 | 27141 |
CIDEB
|
cell death-inducing DFFA-like effector b | Folic Acid affects the expression of CIDEB mRNA |
affects expression
|
mRNA |
16361273
|
| D005492 | 1047 |
CLGN
|
calmegin | Folic Acid results in increased expression of CLGN mRNA |
increases expression
|
mRNA |
11723236
|
| D005492 | 1270 |
CNTF
HCNTF |
ciliary neurotrophic factor | Folic Acid affects the reaction [Cisplatin affects the expression of CNTF mRNA] |
affects expression
/ affects reaction |
mRNA |
16898872
|
| D005492 | 1401 |
CRP
PTX1 |
C-reactive protein, pentraxin-related | [Eicosapentaenoic Acid co-treated with Docosahexaenoic Acids co-treated with Oleic Acid co-treated with Folic Acid co-treated with Vitamin B 6 co-treated with Vitamin E] results in decreased expression of CRP protein |
affects cotreatment
/ decreases expression |
protein |
17237316
|
| D005492 | 1401 |
CRP
PTX1 |
C-reactive protein, pentraxin-related | [Folic Acid co-treated with Riboflavin co-treated with Vitamin B 6 co-treated with Vitamin B 12] results in decreased expression of CRP protein |
affects cotreatment
/ decreases expression |
protein |
16517955
|
| D005492 | 1401 |
CRP
PTX1 |
C-reactive protein, pentraxin-related | Folic Acid results in decreased expression of CRP protein |
decreases expression
|
protein |
16491109
|
| D005492 | 1401 |
CRP
PTX1 |
C-reactive protein, pentraxin-related | [Vitamin E co-treated with Ascorbic Acid co-treated with Folic Acid co-treated with Riboflavin co-treated with Vitamin B 6 co-treated with Vitamin B 12] results in decreased expression of CRP protein |
affects cotreatment
/ decreases expression |
protein |
16517955
|
| D005492 | 1499 |
CTNNB1
CTNNB MRD19 armadillo |
catenin (cadherin-associated protein), beta 1, 88kDa | Folic Acid affects the expression of CTNNB1 mRNA |
affects expression
|
mRNA |
16361273
|
| D005492 | 1075 |
CTSC
CPPI DPP-I DPP1 DPPI HMS JP JPD PALS PDON1 PLS |
cathepsin C (EC:3.4.14.1) | Folic Acid affects the expression of CTSC mRNA |
affects expression
|
mRNA |
17320366
|
| D005492 | 7913 |
DEK
D6S231E |
DEK oncogene | Folic Acid affects the expression of DEK mRNA |
affects expression
|
mRNA |
17320366
|
| D005492 | 1719 |
DHFR
DHFRP1 DYR |
dihydrofolate reductase (EC:1.5.1.3) | DHFR gene mutant form results in decreased abundance of Folic Acid |
decreases abundance
|
gene |
21310277
|
| D005492 | 1719 |
DHFR
DHFRP1 DYR |
dihydrofolate reductase (EC:1.5.1.3) | Folic Acid affects the expression of DHFR mRNA |
affects expression
|
mRNA |
17311948
|
| D005492 | 1719 |
DHFR
DHFRP1 DYR |
dihydrofolate reductase (EC:1.5.1.3) | Leucovorin inhibits the reaction [DHFR gene mutant form results in decreased abundance of Folic Acid] |
decreases abundance
/ decreases reaction |
gene |
21310277
|
| D005492 | 22943 |
DKK1
DKK-1 SK |
dickkopf WNT signaling pathway inhibitor 1 | Folic Acid affects the expression of DKK1 mRNA |
affects expression
|
mRNA |
17320366
|
| D005492 | 22943 |
DKK1
DKK-1 SK |
dickkopf WNT signaling pathway inhibitor 1 | Folic Acid results in increased expression of DKK1 mRNA |
increases expression
|
mRNA |
17868486
|
| D005492 | 1786 |
DNMT1
ADCADN AIM CXXC9 DNMT HSN1E MCMT |
DNA (cytosine-5-)-methyltransferase 1 (EC:2.1.1.37) | Folic Acid affects the expression of DNMT1 mRNA |
affects expression
|
mRNA |
17311948
|
| D005492 | 1788 |
DNMT3A
DNMT3A2 M.HsaIIIA |
DNA (cytosine-5-)-methyltransferase 3 alpha (EC:2.1.1.37) | Folic Acid affects the expression of DNMT3A mRNA |
affects expression
|
mRNA |
17311948
|
| D005492 | 1789 |
DNMT3B
ICF ICF1 M.HsaIIIB |
DNA (cytosine-5-)-methyltransferase 3 beta (EC:2.1.1.37) | Folic Acid affects the expression of DNMT3B mRNA |
affects expression
|
mRNA |
17311948
|
| D005492 | 1805 |
DPT
TRAMP |
dermatopontin | Folic Acid affects the expression of DPT mRNA |
affects expression
|
mRNA |
17320366
|
| D005492 | 1907 |
EDN2
ET2 PPET2 |
endothelin 2 | Folic Acid affects the reaction [Cisplatin affects the expression of EDN2 mRNA] |
affects expression
/ affects reaction |
mRNA |
16898872
|
| D005492 | 2051 |
EPHB6
HEP |
EPH receptor B6 (EC:2.7.10.1) | Folic Acid affects the expression of EPHB6 mRNA |
affects expression
|
mRNA |
17320366
|
| D005492 | 2114 |
ETS2
ETS2IT1 |
v-ets avian erythroblastosis virus E26 oncogene homolog 2 | Folic Acid affects the expression of ETS2 mRNA |
affects expression
|
mRNA |
16361273
|
| D005492 | 84668 |
FAM126A
DRCTNNB1A HCC HLD5 HYCC1 |
family with sequence similarity 126, member A | Folic Acid affects the expression of FAM126A mRNA |
affects expression
|
mRNA |
17320366
|
| D005492 | 355 |
FAS
ALPS1A APO-1 APT1 CD95 FAS1 FASTM TNFRSF6 |
Fas cell surface death receptor | Folic Acid affects the expression of FAS mRNA |
affects expression
|
mRNA |
16611376
|
| D005492 | 2243 |
FGA
Fib2 |
fibrinogen alpha chain | Folic Acid results in increased expression of FGA mRNA |
increases expression
|
mRNA |
17868486
|
| D005492 | 2273 |
FHL1
FHL-1 FHL1A FHL1B FLH1A KYOT SLIM SLIM-1 SLIM1 SLIMMER XMPMA |
four and a half LIM domains 1 | Folic Acid affects the expression of FHL1 mRNA |
affects expression
|
mRNA |
17320366
|
| D005492 | 2348 |
FOLR1
FBP FOLR |
folate receptor 1 (adult) | Folic Acid affects the expression of FOLR1 mRNA |
affects expression
|
mRNA |
17311948
|
| D005492 | 2348 |
FOLR1
FBP FOLR |
folate receptor 1 (adult) | Folic Acid deficiency results in decreased expression of FOLR1 mRNA |
decreases expression
|
mRNA |
20465997
|
| D005492 | 2348 |
FOLR1
FBP FOLR |
folate receptor 1 (adult) | Folic Acid results in decreased expression of FOLR1 mRNA |
decreases expression
|
mRNA |
17616776
|
| D005492 | 2348 |
FOLR1
FBP FOLR |
folate receptor 1 (adult) | FOLR1 gene mutant form results in decreased abundance of Folic Acid |
decreases abundance
|
gene |
19732866
|
| D005492 | 2348 |
FOLR1
FBP FOLR |
folate receptor 1 (adult) | FOLR1 protein results in increased transport of Folic Acid |
increases transport
|
protein |
19732866
|
| D005492 | 2350 |
FOLR2
BETA-HFR FBP FBP/PL-1 FR-BETA FR-P3 |
folate receptor 2 (fetal) | Folic Acid inhibits the reaction [FOLR2 protein results in increased susceptibility to lometrexol] |
decreases reaction
/ increases response to substance |
protein |
16740727
|
| D005492 | 2350 |
FOLR2
BETA-HFR FBP FBP/PL-1 FR-BETA FR-P3 |
folate receptor 2 (fetal) | Folic Acid results in decreased expression of FOLR2 mRNA |
decreases expression
|
mRNA |
17616776
|
| D005492 | 2356 |
FPGS
|
folylpolyglutamate synthase (EC:6.3.2.17) | Folic Acid affects the expression of FPGS mRNA |
affects expression
|
mRNA |
17311948
|
| D005492 | 2512 |
FTL
NBIA3 |
ferritin, light polypeptide | Folic Acid affects the expression of FTL mRNA |
affects expression
|
mRNA |
17868486
|
| D005492 | 2621 |
GAS6
AXLLG AXSF |
growth arrest-specific 6 | Folic Acid affects the expression of GAS6 mRNA |
affects expression
|
mRNA |
17320366
|
| D005492 | 9518 |
GDF15
GDF-15 MIC-1 MIC1 NAG-1 PLAB PTGFB |
growth differentiation factor 15 | Folic Acid affects the reaction [Cisplatin affects the expression of GDF15 mRNA] |
affects expression
/ affects reaction |
mRNA |
16898872
|
| D005492 | 79153 |
GDPD3
|
glycerophosphodiester phosphodiesterase domain containing 3 | Folic Acid affects the expression of GDPD3 mRNA |
affects expression
|
mRNA |
17320366
|
| D005492 | 8836 |
GGH
GH |
gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) (EC:3.4.19.9) | Folic Acid affects the expression of GGH mRNA |
affects expression
|
mRNA |
17311948
|
| D005492 | 2697 |
GJA1
AVSD3 CMDR CX43 DFNB38 GJAL HLHS1 HSS ODDD |
gap junction protein, alpha 1, 43kDa | Folic Acid affects the expression of GJA1 mRNA |
affects expression
|
mRNA |
17320366
|
| D005492 | 2875 |
GPT
AAT1 ALT1 GPT1 |
glutamic-pyruvate transaminase (alanine aminotransferase) (EC:2.6.1.2) | Folic Acid results in decreased expression of GPT protein |
decreases expression
|
protein |
16877991
|
| D005492 | 2987 |
GUK1
GMK |
guanylate kinase 1 (EC:2.7.4.8) | Folic Acid affects the reaction [Cisplatin affects the expression of GUK1 mRNA] |
affects expression
/ affects reaction |
mRNA |
16898872
|
| D005492 | 8739 |
HRK
DP5 HARAKIRI |
harakiri, BCL2 interacting protein (contains only BH3 domain) | Folic Acid affects the expression of HRK mRNA |
affects expression
|
mRNA |
16361273
|
| D005492 | 27129 |
HSPB7
cvHSP |
heat shock 27kDa protein family, member 7 (cardiovascular) | Folic Acid affects the expression of HSPB7 mRNA |
affects expression
|
mRNA |
17320366
|
| D005492 | 3397 |
ID1
ID bHLHb24 |
inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | Folic Acid affects the expression of ID1 mRNA |
affects expression
|
mRNA |
17320366
|
| D005492 | 8519 |
IFITM1
9-27 CD225 DSPA2a IFI17 LEU13 |
interferon induced transmembrane protein 1 | Folic Acid affects the reaction [Cisplatin affects the expression of IFITM1 mRNA] |
affects expression
/ affects reaction |
mRNA |
16898872
|
| D005492 | 10410 |
IFITM3
1-8U DSPA2b IP15 |
interferon induced transmembrane protein 3 | Folic Acid results in decreased expression of IFITM3 mRNA |
decreases expression
|
mRNA |
11723236
|
| D005492 | 3480 |
IGF1R
CD221 IGFIR IGFR JTK13 |
insulin-like growth factor 1 receptor (EC:2.7.10.1) | Folic Acid inhibits the reaction [IGF1R protein results in increased phosphorylation of MAPK1 protein] |
decreases reaction
/ increases phosphorylation |
protein |
16728583
|
| D005492 | 3480 |
IGF1R
CD221 IGFIR IGFR JTK13 |
insulin-like growth factor 1 receptor (EC:2.7.10.1) | Folic Acid inhibits the reaction [IGF1R protein results in increased phosphorylation of MAPK3 protein] |
decreases reaction
/ increases phosphorylation |
protein |
16728583
|
| D005492 | 3480 |
IGF1R
CD221 IGFIR IGFR JTK13 |
insulin-like growth factor 1 receptor (EC:2.7.10.1) | Folic Acid inhibits the reaction [SP1 protein binds to IGF1R promoter] |
affects binding
/ decreases reaction |
promoter |
16728583
|
| D005492 | 3480 |
IGF1R
CD221 IGFIR IGFR JTK13 |
insulin-like growth factor 1 receptor (EC:2.7.10.1) | Folic Acid results in decreased expression of IGF1R mRNA |
decreases expression
|
mRNA |
16728583
|
| D005492 | 3480 |
IGF1R
CD221 IGFIR IGFR JTK13 |
insulin-like growth factor 1 receptor (EC:2.7.10.1) | Folic Acid results in decreased expression of IGF1R protein |
decreases expression
|
protein |
16728583
|
| D005492 | 3488 |
IGFBP5
IBP5 |
insulin-like growth factor binding protein 5 | Folic Acid affects the expression of IGFBP5 mRNA |
affects expression
|
mRNA |
17320366
|
| D005492 | 3558 |
IL2
IL-2 TCGF lymphokine |
interleukin 2 | Folic Acid affects the expression of IL2 mRNA |
affects expression
|
mRNA |
16611376
|
| D005492 | 3576 |
IL8
CXCL8 GCP-1 GCP1 LECT LUCT LYNAP MDNCF MONAP NAF NAP-1 NAP1 |
interleukin 8 | Folic Acid results in decreased expression of IL8 protein |
decreases expression
|
protein |
16491109
|
| D005492 | 3638 |
INSIG1
CL-6 CL6 |
insulin induced gene 1 | Folic Acid results in increased expression of INSIG1 mRNA |
increases expression
|
mRNA |
11723236
|
| D005492 | 3675 |
ITGA3
CD49C GAP-B3 GAPB3 ILNEB MSK18 VCA-2 VL3A VLA3a |
integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | Folic Acid affects the expression of ITGA3 mRNA |
affects expression
|
mRNA |
16361273
|
| D005492 | 3676 |
ITGA4
CD49D IA4 |
integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) | Folic Acid affects the expression of ITGA4 mRNA |
affects expression
|
mRNA |
17320366
|
| D005492 | 3678 |
ITGA5
CD49e FNRA VLA5A |
integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | Folic Acid affects the expression of ITGA5 mRNA |
affects expression
|
mRNA |
16361273
|
| D005492 | 3655 |
ITGA6
CD49f ITGA6B VLA-6 |
integrin, alpha 6 | Folic Acid affects the expression of ITGA6 mRNA |
affects expression
|
mRNA |
16361273
|
| D005492 | 3688 |
ITGB1
CD29 FNRB GPIIA MDF2 MSK12 VLA-BETA VLAB |
integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | Folic Acid affects the expression of ITGB1 mRNA |
affects expression
|
mRNA |
16361273
|
| D005492 | 3725 |
JUN
AP-1 AP1 c-Jun |
jun proto-oncogene | Folic Acid affects the reaction [Cisplatin affects the expression of JUN mRNA] |
affects expression
/ affects reaction |
mRNA |
16898872
|
| D005492 | 9735 |
KNTC1
ROD |
kinetochore associated 1 | Folic Acid affects the expression of KNTC1 mRNA |
affects expression
|
mRNA |
17320366
|
| D005492 | 3861 |
KRT14
CK14 EBS3 EBS4 K14 NFJ |
keratin 14 | Folic Acid results in decreased expression of KRT14 mRNA |
decreases expression
|
mRNA |
11723236
|
| D005492 | 7851 |
MALL
BENE |
mal, T-cell differentiation protein-like | Folic Acid affects the expression of MALL mRNA |
affects expression
|
mRNA |
17320366
|
| D005492 | 4131 |
MAP1B
FUTSCH MAP5 |
microtubule-associated protein 1B | Folic Acid affects the expression of MAP1B mRNA |
affects expression
|
mRNA |
17320366
|
| D005492 | 5594 |
MAPK1
ERK ERK2 ERT1 MAPK2 P42MAPK PRKM1 PRKM2 p38 p40 p41 p41mapk |
mitogen-activated protein kinase 1 (EC:2.7.11.24) | Folic Acid inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein] |
decreases reaction
/ increases phosphorylation |
protein |
16251475
|
| D005492 | 5594 |
MAPK1
ERK ERK2 ERT1 MAPK2 P42MAPK PRKM1 PRKM2 p38 p40 p41 p41mapk |
mitogen-activated protein kinase 1 (EC:2.7.11.24) | Folic Acid inhibits the reaction [IGF1R protein results in increased phosphorylation of MAPK1 protein] |
decreases reaction
/ increases phosphorylation |
protein |
16728583
|
| D005492 | 5595 |
MAPK3
ERK-1 ERK1 ERT2 HS44KDAP HUMKER1A P44ERK1 P44MAPK PRKM3 p44-ERK1 p44-MAPK |
mitogen-activated protein kinase 3 (EC:2.7.11.24) | Folic Acid inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein] |
decreases reaction
/ increases phosphorylation |
protein |
16251475
|
| D005492 | 5595 |
MAPK3
ERK-1 ERK1 ERT2 HS44KDAP HUMKER1A P44ERK1 P44MAPK PRKM3 p44-ERK1 p44-MAPK |
mitogen-activated protein kinase 3 (EC:2.7.11.24) | Folic Acid inhibits the reaction [IGF1R protein results in increased phosphorylation of MAPK3 protein] |
decreases reaction
/ increases phosphorylation |
protein |
16728583
|
| D005492 | 8932 |
MBD2
DMTase NY-CO-41 |
methyl-CpG binding domain protein 2 | Folic Acid affects the expression of MBD2 mRNA |
affects expression
|
mRNA |
17311948
|
| D005492 | 4170 |
MCL1
BCL2L3 EAT MCL1-ES MCL1L MCL1S Mcl-1 TM bcl2-L-3 mcl1/EAT |
myeloid cell leukemia sequence 1 (BCL2-related) | Folic Acid affects the expression of MCL1 mRNA |
affects expression
|
mRNA |
16361273
|
| D005492 | 4193 |
MDM2
ACTFS HDMX hdm2 |
MDM2 oncogene, E3 ubiquitin protein ligase | Folic Acid affects the expression of MDM2 mRNA |
affects expression
|
mRNA |
16361273
|
| D005492 | 11343 |
MGLL
HU-K5 HUK5 MAGL MGL |
monoglyceride lipase (EC:3.1.1.23) | Folic Acid affects the expression of MGLL mRNA |
affects expression
|
mRNA |
17320366
|
| D005492 | 4255 |
MGMT
|
O-6-methylguanine-DNA methyltransferase (EC:2.1.1.63) | [Folic Acid co-treated with MTHFR gene SNP] affects the methylation of MGMT promoter |
affects cotreatment
/ affects methylation |
promoter |
17301267
|
| D005492 | 100507436 |
MICA
MIC-A PERB11.1 |
MHC class I polypeptide-related sequence A | Folic Acid affects the expression of MICA mRNA |
affects expression
|
mRNA |
16361273
|
| D005492 | 4282 |
MIF
GIF GLIF MMIF |
macrophage migration inhibitory factor (glycosylation-inhibiting factor) (EC:5.3.3.12 5.3.2.1) | Folic Acid affects the expression of MIF mRNA |
affects expression
|
mRNA |
17320366
|
| D005492 | 4311 |
MME
CALLA CD10 NEP SFE |
membrane metallo-endopeptidase (EC:3.4.24.11) | Folic Acid affects the expression of MME mRNA |
affects expression
|
mRNA |
17320366
|
| D005492 | 4314 |
MMP3
CHDS6 MMP-3 SL-1 STMY STMY1 STR1 |
matrix metallopeptidase 3 (stromelysin 1, progelatinase) (EC:3.4.24.17) | Folic Acid affects the expression of MMP3 mRNA |
affects expression
|
mRNA |
17320366
|
| D005492 | 4504 |
MT3
GIF GIFB GRIF ZnMT3 |
metallothionein 3 | Folic Acid affects the reaction [Cisplatin affects the expression of MT3 mRNA] |
affects expression
/ affects reaction |
mRNA |
16898872
|
| D005492 | 4524 |
MTHFR
|
methylenetetrahydrofolate reductase (NAD(P)H) (EC:1.5.1.20) | Folic Acid affects the expression of MTHFR mRNA |
affects expression
|
mRNA |
17311948
|
| D005492 | 4524 |
MTHFR
|
methylenetetrahydrofolate reductase (NAD(P)H) (EC:1.5.1.20) | [Folic Acid co-treated with MTHFR gene SNP] affects the methylation of MGMT promoter |
affects cotreatment
/ affects methylation |
gene |
17301267
|
| D005492 | 4524 |
MTHFR
|
methylenetetrahydrofolate reductase (NAD(P)H) (EC:1.5.1.20) | Folic Acid inhibits the reaction [MTHFR gene polymorphism results in increased activity of ACHE protein] |
decreases reaction
/ increases activity |
gene |
16375580
|
| D005492 | 4524 |
MTHFR
|
methylenetetrahydrofolate reductase (NAD(P)H) (EC:1.5.1.20) | MTHFR gene mutant form results in decreased abundance of Folic Acid |
decreases abundance
|
gene |
17115185
|
| D005492 | 4524 |
MTHFR
|
methylenetetrahydrofolate reductase (NAD(P)H) (EC:1.5.1.20) | MTHFR gene polymorphism affects the abundance of Folic Acid |
affects abundance
|
gene |
16621645
16690736 |
| D005492 | 4524 |
MTHFR
|
methylenetetrahydrofolate reductase (NAD(P)H) (EC:1.5.1.20) | MTHFR gene polymorphism affects the metabolism of Folic Acid |
affects metabolic processing
|
gene |
20532609
|
| D005492 | 4524 |
MTHFR
|
methylenetetrahydrofolate reductase (NAD(P)H) (EC:1.5.1.20) | MTHFR gene polymorphism affects the reaction [Folic Acid affects the methylation of CDKN2A promoter] |
affects methylation
/ affects reaction |
gene |
16646054
|
| D005492 | 4524 |
MTHFR
|
methylenetetrahydrofolate reductase (NAD(P)H) (EC:1.5.1.20) | MTHFR gene SNP affects the abundance of Folic Acid |
affects abundance
|
gene |
21869730
|
| D005492 | 4524 |
MTHFR
|
methylenetetrahydrofolate reductase (NAD(P)H) (EC:1.5.1.20) | MTHFR protein affects the metabolism of Folic Acid |
affects metabolic processing
|
protein |
20547447
|
| D005492 | 4548 |
MTR
HMAG MS cblG |
5-methyltetrahydrofolate-homocysteine methyltransferase (EC:2.1.1.13) | Folic Acid affects the expression of MTR mRNA |
affects expression
|
mRNA |
17311948
|
| D005492 | 4552 |
MTRR
MSR cblE |
5-methyltetrahydrofolate-homocysteine methyltransferase reductase (EC:1.16.1.8) | Folic Acid affects the expression of MTRR mRNA |
affects expression
|
mRNA |
17311948
|
| D005492 | 4582 |
MUC1
CA_15-3 CD227 EMA H23AG KL-6 MAM6 MCKD1 MUC-1 MUC-1/SEC MUC-1/X MUC1/ZD PEM PEMT PUM |
mucin 1, cell surface associated | Folic Acid affects the expression of MUC1 mRNA |
affects expression
|
mRNA |
17320366
|
| D005492 | 4651 |
MYO10
|
myosin X | Folic Acid affects the expression of MYO10 mRNA |
affects expression
|
mRNA |
17320366
|
| D005492 | 9 |
NAT1
AAC1 MNAT NAT-1 NATI |
N-acetyltransferase 1 (arylamine N-acetyltransferase) (EC:2.3.1.5) | Folic Acid results in decreased activity of NAT1 protein |
decreases activity
|
protein |
16003948
|
| D005492 | 9 |
NAT1
AAC1 MNAT NAT-1 NATI |
N-acetyltransferase 1 (arylamine N-acetyltransferase) (EC:2.3.1.5) | Folic Acid results in decreased activity of NAT1 protein modified form |
decreases activity
|
protein |
16003948
|
| D005492 | 9 |
NAT1
AAC1 MNAT NAT-1 NATI |
N-acetyltransferase 1 (arylamine N-acetyltransferase) (EC:2.3.1.5) | NAT1 protein results in increased acetylation of Folic Acid metabolite |
increases acetylation
|
protein |
15627487
|
| D005492 | 4684 |
NCAM1
CD56 MSK39 NCAM |
neural cell adhesion molecule 1 (EC:2.7.11.1) | Folic Acid affects the expression of NCAM1 mRNA |
affects expression
|
mRNA |
16361273
|
| D005492 | 653361 |
NCF1
NCF1A NOXO2 SH3PXD1A p47phox |
neutrophil cytosolic factor 1 | Folic Acid inhibits the reaction [Homocysteine results in increased phosphorylation of NCF1 protein] |
decreases reaction
/ increases phosphorylation |
protein |
16845898
|
| D005492 | 3340 |
NDST1
HSST NST1 |
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 (EC:2.8.2.8) | Folic Acid affects the expression of NDST1 mRNA |
affects expression
|
mRNA |
17320366
|
| D005492 | 4790 |
NFKB1
EBP-1 KBF1 NF-kB1 NF-kappa-B NF-kappaB NFKB-p105 NFKB-p50 NFkappaB p105 p50 |
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | Folic Acid affects the expression of NFKB1 mRNA |
affects expression
|
mRNA |
16361273
|
| D005492 | 4792 |
NFKBIA
IKBA MAD-3 NFKBI |
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | Folic Acid affects the expression of NFKBIA mRNA |
affects expression
|
mRNA |
16361273
|
| D005492 | 4792 |
NFKBIA
IKBA MAD-3 NFKBI |
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | Folic Acid inhibits the reaction [Homocysteine results in increased phosphorylation of and results in increased activity of NFKBIA protein] |
decreases reaction
/ increases activity / increases phosphorylation |
protein |
16845898
|
| D005492 | 4833 |
NME4
NDPK-D NM23H4 nm23-H4 |
NME/NM23 nucleoside diphosphate kinase 4 (EC:2.7.4.6) | Folic Acid affects the expression of NME4 mRNA |
affects expression
|
mRNA |
16361273
|
| D005492 | 4855 |
NOTCH4
INT3 NOTCH3 |
notch 4 | Folic Acid affects the reaction [Cisplatin affects the expression of NOTCH4 mRNA] |
affects expression
/ affects reaction |
mRNA |
16898872
|
| D005492 | 9315 |
NREP
C5orf13 D4S114 P311 PRO1873 PTZ17 SEZ17 |
neuronal regeneration related protein | Folic Acid affects the expression of NREP mRNA |
affects expression
|
mRNA |
17320366
|
| D005492 | 4913 |
NTHL1
NTH1 OCTS3 |
nth endonuclease III-like 1 (E. coli) (EC:4.2.99.18) | Folic Acid affects the reaction [Cisplatin affects the expression of NTHL1 mRNA] |
affects expression
/ affects reaction |
mRNA |
16898872
|
| D005492 | 59277 |
NTN4
PRO3091 |
netrin 4 | Folic Acid affects the expression of NTN4 mRNA |
affects expression
|
mRNA |
17320366
|
| D005492 | 142 |
PARP1
ADPRT ADPRT_1 ADPRT1 ARTD1 PARP PARP-1 PPOL pADPRT-1 |
poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) | Folic Acid results in increased cleavage of PARP1 protein |
increases cleavage
|
protein |
16728583
|
| D005492 | 26577 |
PCOLCE2
PCPE2 |
procollagen C-endopeptidase enhancer 2 | Folic Acid affects the expression of PCOLCE2 mRNA |
affects expression
|
mRNA |
17320366
|
| D005492 | 5154 |
PDGFA
PDGF-A PDGF1 |
platelet-derived growth factor alpha polypeptide | Folic Acid affects the expression of PDGFA mRNA |
affects expression
|
mRNA |
16361273
|
| D005492 | 5204 |
PFDN5
MM-1 MM1 PFD5 |
prefoldin subunit 5 | Folic Acid affects the reaction [Cisplatin affects the expression of PFDN5 mRNA] |
affects expression
/ affects reaction |
mRNA |
16898872
|
| D005492 | 5230 |
PGK1
MIG10 PGKA |
phosphoglycerate kinase 1 (EC:2.7.2.3) | Folic Acid affects the expression of PGK1 mRNA |
affects expression
|
mRNA |
17320366
|
| D005492 | 10424 |
PGRMC2
DG6 PMBP |
progesterone receptor membrane component 2 | Folic Acid affects the expression of PGRMC2 mRNA |
affects expression
|
mRNA |
17320366
|
| D005492 | 5295 |
PIK3R1
AGM7 GRB1 p85 p85-ALPHA |
phosphoinositide-3-kinase, regulatory subunit 1 (alpha) | Folic Acid affects the expression of PIK3R1 mRNA |
affects expression
|
mRNA |
16361273
|
| D005492 | 5328 |
PLAU
ATF BDPLT5 QPD UPA URK u-PA |
plasminogen activator, urokinase (EC:3.4.21.73) | Folic Acid affects the expression of PLAU mRNA |
affects expression
|
mRNA |
16361273
|
| D005492 | 5329 |
PLAUR
CD87 U-PAR UPAR URKR |
plasminogen activator, urokinase receptor | Folic Acid affects the expression of PLAUR mRNA |
affects expression
|
mRNA |
16361273
|
| D005492 | 5420 |
PODXL
Gp200 PC PCLP PCLP-1 |
podocalyxin-like | Folic Acid affects the expression of PODXL mRNA |
affects expression
|
mRNA |
17320366
|
| D005492 | 5591 |
PRKDC
DNA-PKcs DNAPK DNPK1 HYRC HYRC1 XRCC7 p350 |
protein kinase, DNA-activated, catalytic polypeptide (EC:2.7.11.1) | Folic Acid affects the expression of PRKDC mRNA |
affects expression
|
mRNA |
16361273
|
| D005492 | 51334 |
PRR16
DSC54 |
proline rich 16 | Folic Acid affects the expression of PRR16 mRNA |
affects expression
|
mRNA |
17320366
|
| D005492 | 5753 |
PTK6
BRK |
protein tyrosine kinase 6 (EC:2.7.10.2) | Folic Acid affects the expression of PTK6 mRNA |
affects expression
|
mRNA |
17320366
|
| D005492 | 83956 |
RACGAP1P
FKSG42 |
Rac GTPase activating protein 1 pseudogene | Folic Acid affects the expression of RACGAP1P mRNA |
affects expression
|
mRNA |
17320366
|
| D005492 | 5894 |
RAF1
CRAF NS5 Raf-1 c-Raf |
v-raf-1 murine leukemia viral oncogene homolog 1 (EC:2.7.11.1) | Folic Acid affects the expression of RAF1 mRNA |
affects expression
|
mRNA |
16361273
|
| D005492 | 5921 |
RASA1
CM-AVM CMAVM GAP PKWS RASA RASGAP p120GAP p120RASGAP |
RAS p21 protein activator (GTPase activating protein) 1 | Folic Acid affects the expression of RASA1 mRNA |
affects expression
|
mRNA |
16361273
|
| D005492 | 8434 |
RECK
ST15 |
reversion-inducing-cysteine-rich protein with kazal motifs | Folic Acid affects the expression of RECK mRNA |
affects expression
|
mRNA |
17320366
|
| D005492 | 389 |
RHOC
ARH9 ARHC H9 RHOH9 |
ras homolog family member C | Folic Acid affects the reaction [Cisplatin affects the expression of RHOC mRNA] |
affects expression
/ affects reaction |
mRNA |
16898872
|
| D005492 | 6119 |
RPA3
REPA3 |
replication protein A3, 14kDa | Folic Acid affects the expression of RPA3 mRNA |
affects expression
|
mRNA |
16361273
|
| D005492 | 6193 |
RPS5
S5 |
ribosomal protein S5 | Folic Acid affects the reaction [Cisplatin affects the expression of RPS5 mRNA] |
affects expression
/ affects reaction |
mRNA |
16898872
|
| D005492 | 6281 |
S100A10
42C ANX2L ANX2LG CAL1L CLP11 Ca[1] GP11 P11 p10 |
S100 calcium binding protein A10 | Folic Acid affects the expression of S100A10 mRNA |
affects expression
|
mRNA |
17320366
|
| D005492 | 6275 |
S100A4
18A2 42A CAPL FSP1 MTS1 P9KA PEL98 |
S100 calcium binding protein A4 | Folic Acid affects the expression of S100A4 mRNA |
affects expression
|
mRNA |
16361273
|
| D005492 | 6303 |
SAT1
DC21 KFSD KFSDX SAT SSAT SSAT-1 |
spermidine/spermine N1-acetyltransferase 1 (EC:2.3.1.57) | Folic Acid results in increased expression of SAT1 mRNA |
increases expression
|
mRNA |
17868486
|
| D005492 | 5055 |
SERPINB2
HsT1201 PAI PAI-2 PAI2 PLANH2 |
serpin peptidase inhibitor, clade B (ovalbumin), member 2 | Folic Acid affects the expression of SERPINB2 mRNA |
affects expression
|
mRNA |
16361273
|
| D005492 | 6470 |
SHMT1
CSHMT SHMT |
serine hydroxymethyltransferase 1 (soluble) (EC:2.1.2.1) | Folic Acid affects the expression of SHMT1 mRNA |
affects expression
|
mRNA |
17311948
|
| D005492 | 6566 |
SLC16A1
HHF7 MCT MCT1 |
solute carrier family 16 (monocarboxylate transporter), member 1 | Folic Acid deficiency results in decreased expression of SLC16A1 mRNA |
decreases expression
|
mRNA |
20465997
|
| D005492 | 6573 |
SLC19A1
CHMD FOLT IFC1 REFC RFC1 |
solute carrier family 19 (folate transporter), member 1 | [4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid results in decreased activity of SLC19A1 protein] which results in decreased uptake of Folic Acid |
decreases activity
/ decreases uptake |
protein |
17034785
|
| D005492 | 6573 |
SLC19A1
CHMD FOLT IFC1 REFC RFC1 |
solute carrier family 19 (folate transporter), member 1 | [4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid results in decreased activity of SLC19A1 protein] which results in decreased uptake of Folic Acid |
decreases activity
/ decreases uptake |
protein |
17034785
|
| D005492 | 6573 |
SLC19A1
CHMD FOLT IFC1 REFC RFC1 |
solute carrier family 19 (folate transporter), member 1 | [5-methyltetrahydrofolate results in decreased activity of SLC19A1 protein] which results in decreased uptake of Folic Acid |
decreases activity
/ decreases uptake |
protein |
17034785
|
| D005492 | 6573 |
SLC19A1
CHMD FOLT IFC1 REFC RFC1 |
solute carrier family 19 (folate transporter), member 1 | Folic Acid affects the expression of SLC19A1 mRNA |
affects expression
|
mRNA |
17311948
|
| D005492 | 6573 |
SLC19A1
CHMD FOLT IFC1 REFC RFC1 |
solute carrier family 19 (folate transporter), member 1 | Folic Acid deficiency results in decreased expression of SLC19A1 mRNA |
decreases expression
|
mRNA |
20465997
|
| D005492 | 6573 |
SLC19A1
CHMD FOLT IFC1 REFC RFC1 |
solute carrier family 19 (folate transporter), member 1 | Folic Acid results in decreased expression of SLC19A1 mRNA |
decreases expression
|
mRNA |
17616776
|
| D005492 | 6573 |
SLC19A1
CHMD FOLT IFC1 REFC RFC1 |
solute carrier family 19 (folate transporter), member 1 | Folic Acid results in decreased expression of SLC19A1 protein |
decreases expression
|
protein |
17616776
|
| D005492 | 6573 |
SLC19A1
CHMD FOLT IFC1 REFC RFC1 |
solute carrier family 19 (folate transporter), member 1 | [Indomethacin results in decreased activity of SLC19A1 protein] which results in decreased uptake of Folic Acid |
decreases activity
/ decreases uptake |
protein |
17034785
|
| D005492 | 6573 |
SLC19A1
CHMD FOLT IFC1 REFC RFC1 |
solute carrier family 19 (folate transporter), member 1 | [Methotrexate results in decreased activity of SLC19A1 protein] which results in decreased uptake of Folic Acid |
decreases activity
/ decreases uptake |
protein |
17034785
|
| D005492 | 6573 |
SLC19A1
CHMD FOLT IFC1 REFC RFC1 |
solute carrier family 19 (folate transporter), member 1 | SLC19A1 gene SNP affects the uptake of and affects the localization of Folic Acid |
affects localization
/ affects uptake |
gene |
16750224
|
| D005492 | 6573 |
SLC19A1
CHMD FOLT IFC1 REFC RFC1 |
solute carrier family 19 (folate transporter), member 1 | SLC19A1 protein results in increased uptake of Folic Acid |
increases uptake
|
protein |
16900951
|
| D005492 | 6580 |
SLC22A1
HOCT1 OCT1 oct1_cds |
solute carrier family 22 (organic cation transporter), member 1 | Folic Acid deficiency results in decreased expression of SLC22A1 mRNA |
decreases expression
|
mRNA |
20465997
|
| D005492 | 6514 |
SLC2A2
GLUT2 |
solute carrier family 2 (facilitated glucose transporter), member 2 | Folic Acid deficiency results in decreased expression of SLC2A2 mRNA |
decreases expression
|
mRNA |
20465997
|
| D005492 | 30061 |
SLC40A1
FPN1 HFE4 IREG1 MST079 MTP1 SLC11A3 |
solute carrier family 40 (iron-regulated transporter), member 1 | Folic Acid affects the expression of SLC40A1 mRNA |
affects expression
|
mRNA |
17868486
|
| D005492 | 113235 |
SLC46A1
G21 HCP1 PCFT |
solute carrier family 46 (folate transporter), member 1 | 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid inhibits the reaction [SLC46A1 protein results in increased transport of Folic Acid] |
decreases reaction
/ increases transport |
protein |
17475902
|
| D005492 | 113235 |
SLC46A1
G21 HCP1 PCFT |
solute carrier family 46 (folate transporter), member 1 | 5-methyltetrahydrofolate inhibits the reaction [SLC46A1 protein results in increased transport of Folic Acid] |
decreases reaction
/ increases transport |
protein |
17475902
|
| D005492 | 113235 |
SLC46A1
G21 HCP1 PCFT |
solute carrier family 46 (folate transporter), member 1 | Folic Acid deficiency results in decreased expression of SLC46A1 mRNA |
decreases expression
|
mRNA |
20465997
|
| D005492 | 113235 |
SLC46A1
G21 HCP1 PCFT |
solute carrier family 46 (folate transporter), member 1 | Folic Acid results in decreased expression of SLC46A1 mRNA |
decreases expression
|
mRNA |
17616776
|
| D005492 | 113235 |
SLC46A1
G21 HCP1 PCFT |
solute carrier family 46 (folate transporter), member 1 | Leucovorin inhibits the reaction [SLC46A1 protein results in increased transport of Folic Acid] |
decreases reaction
/ increases transport |
protein |
17475902
|
| D005492 | 113235 |
SLC46A1
G21 HCP1 PCFT |
solute carrier family 46 (folate transporter), member 1 | Methotrexate inhibits the reaction [SLC46A1 protein results in increased transport of Folic Acid] |
decreases reaction
/ increases transport |
protein |
17475902
|
| D005492 | 113235 |
SLC46A1
G21 HCP1 PCFT |
solute carrier family 46 (folate transporter), member 1 | SLC46A1 protein results in increased transport of Folic Acid |
increases transport
|
protein |
17129779
17446347 17475902 19762432 |
| D005492 | 113235 |
SLC46A1
G21 HCP1 PCFT |
solute carrier family 46 (folate transporter), member 1 | Sulfobromophthalein inhibits the reaction [SLC46A1 protein results in increased transport of Folic Acid] |
decreases reaction
/ increases transport |
protein |
17475902
|
| D005492 | 9056 |
SLC7A7
LAT3 LPI MOP-2 Y+LAT1 y+LAT-1 |
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7 | Folic Acid affects the expression of SLC7A7 mRNA |
affects expression
|
mRNA |
17868486
|
| D005492 | 6659 |
SOX4
EVI16 |
SRY (sex determining region Y)-box 4 | Folic Acid results in increased expression of SOX4 mRNA |
increases expression
|
mRNA |
17868486
|
| D005492 | 6667 |
SP1
|
Sp1 transcription factor | Folic Acid inhibits the reaction [SP1 protein binds to IGF1R promoter] |
affects binding
/ decreases reaction |
protein |
16728583
|
| D005492 | 6690 |
SPINK1
PCTT PSTI Spink3 TATI TCP |
serine peptidase inhibitor, Kazal type 1 | Folic Acid results in increased expression of SPINK1 mRNA |
increases expression
|
mRNA |
17868486
|
| D005492 | 6876 |
TAGLN
SM22 SMCC TAGLN1 WS3-10 |
transgelin | Folic Acid affects the expression of TAGLN mRNA |
affects expression
|
mRNA |
17320366
|
| D005492 | 4071 |
TM4SF1
H-L6 L6 M3S1 TAAL6 |
transmembrane 4 L six family member 1 | Folic Acid affects the expression of TM4SF1 mRNA |
affects expression
|
mRNA |
17320366
|
| D005492 | 8795 |
TNFRSF10B
CD262 DR5 KILLER KILLER/DR5 TRAIL-R2 TRAILR2 TRICK2 TRICK2A TRICK2B TRICKB ZTNFR9 |
tumor necrosis factor receptor superfamily, member 10b | Folic Acid affects the expression of TNFRSF10B mRNA |
affects expression
|
mRNA |
16361273
|
| D005492 | 8764 |
TNFRSF14
ATAR CD270 HVEA HVEM LIGHTR TR2 |
tumor necrosis factor receptor superfamily, member 14 | Folic Acid affects the expression of TNFRSF14 mRNA |
affects expression
|
mRNA |
16361273
|
| D005492 | 7157 |
TP53
BCC7 LFS1 P53 TRP53 |
tumor protein p53 | Folic Acid affects the expression of TP53 mRNA |
affects expression
|
mRNA |
16361273
16611376 |
| D005492 | 7157 |
TP53
BCC7 LFS1 P53 TRP53 |
tumor protein p53 | Folic Acid affects the expression of TP53 protein |
affects expression
|
protein |
16361273
|
| D005492 | 7185 |
TRAF1
EBI6 MGC:10353 |
TNF receptor-associated factor 1 | Folic Acid affects the expression of TRAF1 mRNA |
affects expression
|
mRNA |
16361273
|
| D005492 | 9618 |
TRAF4
CART1 MLN62 RNF83 |
TNF receptor-associated factor 4 | Folic Acid affects the expression of TRAF4 mRNA |
affects expression
|
mRNA |
16361273
|
| D005492 | 7189 |
TRAF6
MGC:3310 RNF85 |
TNF receptor-associated factor 6, E3 ubiquitin protein ligase | Folic Acid affects the expression of TRAF6 mRNA |
affects expression
|
mRNA |
16361273
|
| D005492 | 10293 |
TRAIP
RNF206 TRIP |
TRAF interacting protein | Folic Acid affects the expression of TRAIP mRNA |
affects expression
|
mRNA |
16361273
|
| D005492 | 7846 |
TUBA1A
B-ALPHA-1 LIS3 TUBA3 |
tubulin, alpha 1a | Folic Acid affects the reaction [Cisplatin affects the expression of TUBA1A mRNA] |
affects expression
/ affects reaction |
mRNA |
16898872
|
| D005492 | 55000 |
TUG1
LINC00080 NCRNA00080 TI-227H |
taurine up-regulated 1 (non-protein coding) | Folic Acid results in increased expression of TUG1 mRNA |
increases expression
|
mRNA |
17868486
|
| D005492 | 10628 |
TXNIP
EST01027 HHCPA78 THIF VDUP1 |
thioredoxin interacting protein | Folic Acid results in increased expression of TXNIP mRNA |
increases expression
|
mRNA |
11723236
|
| D005492 | 7298 |
TYMS
HST422 TMS TS |
thymidylate synthetase (EC:2.1.1.45) | Folic Acid affects the expression of TYMS mRNA |
affects expression
|
mRNA |
17311948
17320366 |
| D005492 | 7298 |
TYMS
HST422 TMS TS |
thymidylate synthetase (EC:2.1.1.45) | Folic Acid analog results in decreased activity of TYMS protein |
decreases activity
|
protein |
2909728
|
| D005492 | 54532 |
USP53
|
ubiquitin specific peptidase 53 | Folic Acid affects the expression of USP53 mRNA |
affects expression
|
mRNA |
17320366
|
| D005492 | 7422 |
VEGFA
MVCD1 VEGF VPF |
vascular endothelial growth factor A | Folic Acid affects the expression of VEGFA mRNA |
affects expression
|
mRNA |
16361273
|
| D005492 | 389136 |
VGLL3
VGL-3 VGL3 |
vestigial like 3 (Drosophila) | Folic Acid affects the expression of VGLL3 mRNA |
affects expression
|
mRNA |
17320366
|
| D005492 | 8840 |
WISP1
CCN4 WISP1c WISP1i WISP1tc |
WNT1 inducible signaling pathway protein 1 | Folic Acid affects the expression of WISP1 mRNA |
affects expression
|
mRNA |
17320366
|
| D005492 | 7474 |
WNT5A
hWNT5A |
wingless-type MMTV integration site family, member 5A | Folic Acid affects the expression of WNT5A mRNA |
affects expression
|
mRNA |
17320366
|
| D005492 | 51222 |
ZNF219
ZFP219 |
zinc finger protein 219 | Folic Acid affects the expression of ZNF219 mRNA |
affects expression
|
mRNA |
17320366
|
Related Disease
Diseases related to proteins in ChEMBL interactions
OMIM (32)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #117800 | Apocrine gland secretion, variation in |
Q96J66
|
| #614490 | Blood group, junior system; jr |
Q9UNQ0
|
| #114500 | Colorectal cancer; crc |
P84022
|
| #127750 | Dementia, lewy body; dlb |
P37840
|
| #119900 | Digital clubbing, isolated congenital |
P15428
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #301500 | Fabry disease |
P06280
|
| #608013 | Gaucher disease, perinatal lethal |
P04062
|
| #230800 | Gaucher disease, type i |
P04062
|
| #230900 | Gaucher disease, type ii |
P04062
|
| #231000 | Gaucher disease, type iii |
P04062
|
| #231005 | Gaucher disease, type iiic |
P04062
|
| #232300 | Glycogen storage disease ii |
P10253
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 |
P15428
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #613795 | Loeys-dietz syndrome, type 3; lds3 |
P84022
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #257200 | Niemann-pick disease, type a |
P17405
|
| #607616 | Niemann-pick disease, type b |
P17405
|
| #168601 | Parkinson disease 1, autosomal dominant; park1 |
P37840
|
| #605543 | Parkinson disease 4, autosomal dominant; park4 |
P37840
|
| #168600 | Parkinson disease, late-onset; pd |
P04062
P37840 |
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
| #138900 | Uric acid concentration, serum, quantitative trait locus 1; uaqtl1 |
Q9UNQ0
|
KEGG DISEASE (27)
| KEGG | disease name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
|
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00066 | Lewy body dementia (LBD) |
P04062
(related)
P37840 (related) |
| H00126 | Gaucher disease |
P04062
(related)
|
| H00426 | Defects in the degradation of ganglioside |
P04062
(related)
|
| H00810 | Progressive myoclonic epilepsy (PME) |
P04062
(related)
|
| H00125 | Fabry disease |
P06280
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H00069 | Glycogen storage diseases (GSD) |
P10253
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00457 | Primary hypertrophic osteoarthropathy (PHO) |
P15428
(related)
|
| H01246 | Isolated congenital nail clubbing (ICNC) |
P15428
(related)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P16473
(related)
|
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H00137 | Niemann-Pick disease (NPD) typeA and B |
P17405
(related)
|
| H00424 | Defects in the degradation of sphingomyelin |
P17405
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00057 | Parkinson's disease (PD) |
P37840
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q03164
(related)
Q03164 (marker) |
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00480 | Non-syndromic X-linked mental retardation |
Q99714
(related)
|
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q9NUW8
(related)
|
Diseases related to CTD interactions
101 disease from interactions of metabolites
| MeSH disease | OMIM | compound | disease name | evidence type |
reference
pmid |
|---|---|---|---|---|---|
| D000014 | D005492 | Abnormalities, Drug-Induced |
therapeutic
|
11096168
16112698 |
|
| D058186 | D005492 | Acute Kidney Injury |
marker/mechanism
|
135854
562503 745638 851170 1068326 4142233 5070373 7531211 8594875 10980121 11532093 15149334 15625121 16316344 16595132 17003819 18480750 18626492 19552531 |
|
| D000236 | D005492 | Adenoma |
therapeutic
|
16963246
|
|
| D000370 | D005492 | Ageusia |
therapeutic
|
3214955
|
|
| D000430 | D005492 | Alcohol Withdrawal Delirium |
therapeutic
|
7220787
|
|
| D000544 | D005492 | Alzheimer Disease |
marker/mechanism
therapeutic |
15607954
17116317 |
|
| D000740 | D005492 | Anemia |
marker/mechanism
|
523178
749158 939927 2414185 5530036 12187553 15249150 16454396 |
|
| D000741 | D005492 | Anemia, Aplastic |
therapeutic
|
12028229
|
|
| D000743 | D005492 | Anemia, Hemolytic |
therapeutic
|
5774135
|
|
| D000744 | D005492 | Anemia, Hemolytic, Autoimmune |
therapeutic
|
5694067
|
|
| D000748 | D005492 | Anemia, Macrocytic |
marker/mechanism
therapeutic |
167444
1243953 9169341 15955964 |
|
| D000749 | D005492 | Anemia, Megaloblastic |
marker/mechanism
therapeutic |
601569
1922593 2535199 4169978 4175396 4264432 4627864 4729182 5618821 6021848 8349867 14227437 16353713 19110522 |
|
| D000755 | D005492 | Anemia, Sickle Cell |
therapeutic
|
18593679
|
|
| D000756 | D005492 | Anemia, Sideroblastic |
therapeutic
|
7986730
|
|
| D000757 | D005492 | Anencephaly |
therapeutic
|
12397633
15846825 |
|
| D001002 | D005492 | Anuria |
marker/mechanism
|
851170
|
|
| D001161 | D005492 | Arteriosclerosis |
therapeutic
|
17118406
|
|
| D015535 | D005492 | Arthritis, Psoriatic |
therapeutic
|
17190135
|
|
| D001259 | D005492 | Ataxia |
marker/mechanism
|
7442434
|
|
| D001284 | D005492 | Atrophy |
therapeutic
|
23690582
|
|
| D001321 | D005492 | Autistic Disorder |
marker/mechanism
|
21388746
|
|
| D001714 | D005492 | Bipolar Disorder |
therapeutic
|
20636639
|
|
| D001925 | D005492 | Brain Damage, Chronic |
therapeutic
|
23690582
|
|
| D001927 | D005492 | Brain Diseases |
marker/mechanism
therapeutic |
4504035
6824947 7279316 |
|
| D001943 | D005492 | Breast Neoplasms |
therapeutic
|
16777985
|
|
| D002292 | D005492 | Carcinoma, Renal Cell |
therapeutic
|
10663624
|
|
| D018376 | D005492 | Cardiovascular Abnormalities |
therapeutic
|
11096168
|
|
| D002318 | D005492 | Cardiovascular Diseases |
therapeutic
|
16755160
|
|
| D002386 | D005492 | Cataract |
therapeutic
|
11438049
|
|
| D002524 | D005492 | Cerebellar Ataxia |
therapeutic
|
4022349
|
|
| D002971 | D005492 | Cleft Lip |
marker/mechanism
therapeutic |
11096168
21254359 |
|
| D002972 | D005492 | Cleft Palate |
marker/mechanism
|
8946559
21254359 |
|
| D003072 | D005492 | Cognition Disorders |
marker/mechanism
therapeutic |
15824266
16315636 23690582 |
|
| D015179 | D005492 | Colorectal Neoplasms |
marker/mechanism
therapeutic |
16963246
16985020 17087956 17116713 17245555 |
|
| D003117 | D005492 | Color Vision Defects |
therapeutic
|
15937433
|
|
| D000013 | D005492 | Congenital Abnormalities |
therapeutic
|
11096168
|
|
| D023903 | D005492 | Coronary Restenosis |
marker/mechanism
|
15215483
|
|
| D003704 | D005492 | Dementia |
marker/mechanism
|
7527320
|
|
| D003866 | D005492 | Depressive Disorder |
marker/mechanism
|
7527320
|
|
| D003924 | D005492 | Diabetes Mellitus, Type 2 |
therapeutic
|
16886840
|
|
| D004195 | D005492 | Disease Models, Animal |
marker/mechanism
|
20406136
|
|
| D004244 | D005492 | Dizziness |
therapeutic
|
3214955
|
|
| D056486 | D005492 | Drug-Induced Liver Injury |
marker/mechanism
|
15338491
20548288 |
|
| D064420 | D005492 | Drug-Related Side Effects and Adverse Reactions |
marker/mechanism
|
16166815
|
|
| D016889 | D005492 | Endometrial Neoplasms |
therapeutic
|
17301261
|
|
| D004827 | D005492 | Epilepsy |
marker/mechanism
|
1115018
4169978 4212019 |
|
| D017889 | D005492 | Exfoliation Syndrome |
marker/mechanism
|
16504073
|
|
| D005235 | D005492 | Fatty Liver, Alcoholic |
therapeutic
|
20118189
|
|
| D063647 | D005492 | Fetal Alcohol Spectrum Disorders |
marker/mechanism
|
22666445
|
|
| D005494 | D005492 | Folic Acid Deficiency |
therapeutic
|
5359954
5694067 |
|
| D005756 | D005492 | Gastritis |
marker/mechanism
|
17171786
|
|
| D005832 | D005492 | Genital Diseases, Male |
marker/mechanism
|
15013062
|
|
| D005901 | D005492 | Glaucoma |
marker/mechanism
|
16504073
|
|
| D006261 | D005492 | Headache |
therapeutic
|
3214955
|
|
| D006330 | D005492 | Heart Defects, Congenital |
therapeutic
|
16524890
17286298 19436079 19641857 |
|
| D006402 | D005492 | Hematologic Diseases |
therapeutic
|
2891393
|
|
| D006679 | D005492 | HIV Seropositivity |
marker/mechanism
|
17209195
|
|
| D006849 | D005492 | Hydrocephalus |
marker/mechanism
|
14324085
|
|
| D020138 | D005492 | HYPERHOMOCYSTEINEMIA |
marker/mechanism
therapeutic |
11598393
15493348 15847747 16395265 16397167 16433478 16755160 16865747 20116427 20406136 21893018 |
|
| D006948 | D005492 | Hyperkinesis |
therapeutic
|
20636639
|
|
| D006973 | D005492 | Hypertension |
marker/mechanism
therapeutic |
15190049
17324744 18087553 |
|
| D007021 | D005492 | Hypospadias |
therapeutic
|
19270804
|
|
| D007674 | D005492 | Kidney Diseases |
marker/mechanism
|
160016
193486 1482756 2386429 2840627 4336412 11832423 14633603 18633340 19435794 19934081 20116427 20406136 21647593 |
|
| D007676 | D005492 | Kidney Failure, Chronic |
marker/mechanism
|
4810836
|
|
| D007683 | D005492 | Kidney Tubular Necrosis, Acute |
marker/mechanism
|
12969123
12969128 14633603 18480750 |
|
| D008107 | D005492 | Liver Diseases |
marker/mechanism
|
16877991
|
|
| D008180 | D005492 | Lupus Erythematosus, Systemic |
marker/mechanism
|
9758264
17718048 |
|
| D016778 | D005492 | Malaria, Falciparum |
therapeutic
|
4922770
|
|
| D019767 | D005492 | Maxillofacial Abnormalities |
therapeutic
|
16832597
|
|
| D008545 | D005492 | Melanoma |
therapeutic
|
10663624
|
|
| D052016 | D005492 | Mucositis |
therapeutic
|
8958188
|
|
| D009135 | D005492 | Muscular Diseases |
therapeutic
|
4148461
|
|
| D009303 | D005492 | Nasopharyngeal Neoplasms |
therapeutic
|
21941485
|
|
| D009369 | D005492 | Neoplasms |
marker/mechanism
|
6061664
|
|
| D009374 | D005492 | Neoplasms, Experimental |
therapeutic
|
10449194
|
|
| D009395 | D005492 | Nephritis, Interstitial |
marker/mechanism
|
15013062
|
|
| D009422 | D005492 | Nervous System Diseases |
marker/mechanism
|
5343988
|
|
| D009436 | D005492 | Neural Tube Defects |
marker/mechanism
therapeutic |
8605127
10452927 10612975 12660568 14598335 16112698 17438019 17688467 19180646 20060418 |
|
| D009503 | D005492 | Neutropenia |
therapeutic
|
3265540
16322990 |
|
| C541083 | D005492 | Non-alcoholic Fatty Liver Disease |
marker/mechanism
|
20548288
|
|
| D009901 | D005492 | Optic Nerve Diseases |
therapeutic
|
15937433
|
|
| D010018 | D005492 | Osteomalacia |
therapeutic
|
4148461
|
|
| D010523 | D005492 | Peripheral Nervous System Diseases |
marker/mechanism
|
7527320
|
|
| D049188 | D005492 | Prenatal Injuries |
marker/mechanism
therapeutic |
16112698
20544798 |
|
| D011507 | D005492 | Proteinuria |
marker/mechanism
|
20116427
|
|
| D011565 | D005492 | Psoriasis |
therapeutic
|
15807694
|
|
| D011602 | D005492 | Psychophysiologic Disorders |
therapeutic
|
4169978
|
|
| D051437 | D005492 | Renal Insufficiency |
marker/mechanism
|
4082191
14661866 15013062 15728788 |
|
| D012559 | D005492 | Schizophrenia |
therapeutic
|
16641680
|
|
| D012607 | D005492 | Scotoma |
therapeutic
|
15937433
|
|
| D012640 | D005492 | Seizures |
marker/mechanism
|
1463588
6462463 6824947 7279316 9758264 9806067 |
|
| D012851 | D005492 | Sinus Thrombosis, Intracranial |
therapeutic
|
18786290
|
|
| D012871 | D005492 | Skin Diseases |
marker/mechanism
therapeutic |
18709164
19270796 |
|
| D013118 | D005492 | Spinal Cord Diseases |
marker/mechanism
therapeutic |
7527320
16361298 |
|
| D016135 | D005492 | Spinal Dysraphism |
marker/mechanism
therapeutic |
12397633
15846825 18655127 20544798 |
|
| D013182 | D005492 | Sprue, Tropical |
therapeutic
|
4951496
|
|
| D013274 | D005492 | Stomach Neoplasms |
marker/mechanism
|
17171786
|
|
| D020521 | D005492 | Stroke |
therapeutic
|
16517955
16534029 |
|
| D013921 | D005492 | Thrombocytopenia |
therapeutic
|
8958188
|
|
| D014123 | D005492 | Toxoplasmosis |
therapeutic
|
8228015
|
|
| D014511 | D005492 | Uremia |
marker/mechanism
|
4082191
|