Plant Species


Cumulative plant class count

class name count
rosids 5
eudicotyledons 1

Cumulative family count

class name count
Enterobacteriaceae 5
Brassicaceae 5
Amaranthaceae 1

KEGG BRITE br08003 External link 512


Categories (0)

br08003 Category # of metabolite

metabolites link (0)

br08003 Category KEGG ID KNApSAcK ID

Metabolite list (7)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
figure
C00001539 External link 512 Folic acid
CHEMBL277040
CHEMBL1622
D005492
34 / 32 / 27 178 / 101
C00007248 External link 512 7,8-Dihydrofolate
/ 7,8-Dihydrofolic acid
CHEMBL46294
CHEMBL1371525
C010920
10 / 10 / 14 3 / 0
C00007249 External link 512 THF
/ THFA
/ Tetrahydrofolate
/ Tetrahydrofolic acid
CHEMBL2021342
CHEMBL2074655
1 / 0 / 0
C00007250 External link 512 5,10-Methylenetetrahydrofolic acid
CHEMBL117348
C00007251 External link 512 10-Formyl-THF
C00007252 External link 512 5-Methyl-tetrahydrofolate
/ 5-Methyltetrahydrofolic acid
CHEMBL1221561
CHEMBL1231574
CHEMBL2358502
C005984
7 / 3
C00019687 External link 512 Anhydroleucovorin
/ 5,10-Methenyltetrahydrofolate
CHEMBL46521
C018092
2 / 2 / 1

Human Protein / Gene in interactions

36 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P00352 Retinal dehydrogenase 1 Enzyme C00001539 C00007248 0 / 0
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00001539 C00007248 1 / 2
O00255 Menin Unclassified protein C00001539 C00007248 2 / 5
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00001539 C00007248 1 / 1
B2RXH2 Lysine-specific demethylase 4E Enzyme C00001539 C00007248 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00001539 C00007248 0 / 0
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00001539 C00007248 2 / 2
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00001539 C00007248 3 / 3
P06280 Alpha-galactosidase A Enzyme C00001539 C00007248 1 / 1
P04818 Thymidylate synthase Transferase C00001539 C00019687 0 / 0
Q05932 Folylpolyglutamate synthase, mitochondrial Enzyme C00001539 C00007249 0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00001539 0 / 0
O15439 Multidrug resistance-associated protein 4 Unclassified protein C00001539 0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00001539 2 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00001539 0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00001539 0 / 0
P17405 Sphingomyelin phosphodiesterase Enzyme C00001539 2 / 2
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00001539 1 / 0
O75496 Geminin Unclassified protein C00001539 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00001539 0 / 1
Q9UNQ0 ATP-binding cassette sub-family G member 2 ATP binding cassette C00001539 2 / 0
P16473 Thyrotropin receptor Glycohormone receptor C00001539 3 / 2
P11586 C-1-tetrahydrofolate synthase, cytoplasmic Enzyme C00019687 2 / 1
P55210 Caspase-7 C14 C00007248 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00001539 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00001539 0 / 1
Q9UNA4 DNA polymerase iota Enzyme C00001539 0 / 0
P37840 Alpha-synuclein Unclassified protein C00001539 4 / 2
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00001539 0 / 0
Q9UBT6 DNA polymerase kappa Enzyme C00001539 0 / 0
O15245 Solute carrier family 22 member 1 Drug uniporter C00001539 0 / 0
P10253 Lysosomal alpha-glucosidase Hydrolase C00001539 1 / 1
P04062 Glucosylceramidase Enzyme C00001539 6 / 4
P06746 DNA polymerase beta Enzyme C00001539 0 / 0
Q96QA9 Multidrug resistance associated protein Unclassified protein C00001539 0 / 0
Q96J66 ATP-binding cassette sub-family C member 11 Unclassified protein C00001539 1 / 0

180 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
10840 ALDH1L1, 10-FTHFDH, 10-fTHF, FDH, FTHFD aldehyde dehydrogenase 1 family, member L1 (EC:1.5.1.6) C00001539 C00007252
2348 FOLR1, FBP, FOLR folate receptor 1 (adult) C00001539 C00007252
4524 MTHFR methylenetetrahydrofolate reductase (NAD(P)H) (EC:1.5.1.20) C00001539 C00007252
4548 MTR, HMAG, MS, cblG 5-methyltetrahydrofolate-homocysteine methyltransferase (EC:2.1.1.13) C00001539 C00007252
9 NAT1, AAC1, MNAT, NAT-1, NATI N-acetyltransferase 1 (arylamine N-acetyltransferase) (EC:2.3.1.5) C00001539 C00007248
6573 SLC19A1, CHMD, FOLT, IFC1, REFC, RFC1 solute carrier family 19 (folate transporter), member 1 C00001539 C00007252
113235 SLC46A1, G21, HCP1, PCFT solute carrier family 46 (folate transporter), member 1 C00001539 C00007252
3480 IGF1R, CD221, IGFIR, IGFR, JTK13 insulin-like growth factor 1 receptor (EC:2.7.10.1) C00001539 C00007248
5328 PLAU, ATF, BDPLT5, QPD, UPA, URK, u-PA plasminogen activator, urokinase (EC:3.4.21.73) C00001539
10891 PPARGC1A, LEM6, PGC-1(alpha), PGC-1v, PGC1, PGC1A, PPARGC1 peroxisome proliferator-activated receptor gamma, coactivator 1 alpha C00007248
4363 ABCC1, ABC29, ABCC, GS-X, MRP, MRP1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 C00001539
9429 ABCG2, ABC15, ABCP, BCRP, BCRP1, BMDP, CD338, CDw338, EST157481, GOUT1, MRX, MXR, MXR1, UAQTL1 ATP-binding cassette, sub-family G (WHITE), member 2 C00001539
43 ACHE, ACEE, ARACHE, N-ACHE, YT acetylcholinesterase (EC:3.1.1.7) C00001539
57007 ACKR3, CMKOR1, CXC-R7, CXCR-7, CXCR7, GPR159, RDC-1, RDC1 atypical chemokine receptor 3 C00001539
51554 ACKR4, CC-CKR-11, CCBP2, CCR-11, CCR10, CCR11, CCRL1, CCX_CKR, CCX-CKR, CKR-11, PPR1, VSHK1 atypical chemokine receptor 4 C00001539
59 ACTA2, AAT6, ACTSA, MYMY5 actin, alpha 2, smooth muscle, aorta C00001539
70 ACTC1, ACTC, ASD5, CMD1R, CMH11, LVNC4 actin, alpha, cardiac muscle 1 C00001539
60312 AFAP1, AFAP, AFAP-110, AFAP110 actin filament associated protein 1 C00001539
10551 AGR2, AG2, GOB-4, HAG-2, PDIA17, XAG-2 anterior gradient 2 C00001539
205 AK4, AK_4, AK3, AK3L1, AK3L2 adenylate kinase 4 (EC:2.7.4.10 2.7.4.6) C00001539
9590 AKAP12, AKAP250, SSeCKS A kinase (PRKA) anchor protein 12 C00001539
213 ALB, PRO0883, PRO0903, PRO1341 albumin C00001539
216 ALDH1A1, ALDC, ALDH-E1, ALDH1, ALDH11, PUMB1, RALDH1 aldehyde dehydrogenase 1 family, member A1 (EC:1.2.1.36) C00001539
27063 ANKRD1, ALRP, C-193, CARP, CVARP, MCARP, bA320F15.2 ankyrin repeat domain 1 (cardiac muscle) C00001539
312 ANXA13, ANX13, ISA annexin A13 C00001539
338 APOB, FLDB, LDLCQ4 apolipoprotein B C00001539
9411 ARHGAP29, PARG1, RP11-255E17.1 Rho GTPase activating protein 29 C00001539
10123 ARL4C, ARL7, LAK ADP-ribosylation factor-like 4C C00001539
57412 AS3MT, CYT19 arsenic (+3 oxidation state) methyltransferase (EC:2.1.1.137) C00001539
1388 ATF6B, CREB-RP, CREBL1, G13 activating transcription factor 6 beta C00001539
472 ATM, AT1, ATA, ATC, ATD, ATDC, ATE, TEL1, TELO1 ataxia telangiectasia mutated (EC:2.7.11.1) C00001539
567 B2M beta-2-microglobulin C00001539
581 BAX, BCL2L4 BCL2-associated X protein C00001539
596 BCL2, Bcl-2, PPP1R50 B-cell CLL/lymphoma 2 C00001539
10018 BCL2L11, BAM, BIM, BOD BCL2-like 11 (apoptosis facilitator) C00001539
51283 BFAR, BAR, RNF47 bifunctional apoptosis regulator C00001539
329 BIRC2, API1, HIAP2, Hiap-2, MIHB, RNF48, c-IAP1, cIAP1 baculoviral IAP repeat containing 2 C00001539
330 BIRC3, AIP1, API2, CIAP2, HAIP1, HIAP1, MALT2, MIHC, RNF49, c-IAP2 baculoviral IAP repeat containing 3 C00001539
664 BNIP3, NIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 C00001539
665 BNIP3L, BNIP3a, NIX BCL2/adenovirus E1B 19kDa interacting protein 3-like C00001539
837 CASP4, ICE(rel)II, ICEREL-II, ICH-2, Mih1/TX, TX caspase 4, apoptosis-related cysteine peptidase (EC:3.4.22.57) C00001539
839 CASP6, MCH2 caspase 6, apoptosis-related cysteine peptidase (EC:3.4.22.59) C00001539
841 CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5 caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) C00001539
6347 CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF chemokine (C-C motif) ligand 2 C00001539
595 CCND1, BCL1, D11S287E, PRAD1, U21B31 cyclin D1 C00001539
896 CCND3 cyclin D3 C00001539
898 CCNE1, CCNE cyclin E1 C00001539
999 CDH1, Arc-1, CD324, CDHE, ECAD, LCAM, UVO cadherin 1, type 1, E-cadherin (epithelial) C00001539
1012 CDH13, CDHH, P105 cadherin 13 (EC:3.6.1.3) C00001539
1001 CDH3, CDHP, HJMD, PCAD cadherin 3, type 1, P-cadherin (placental) C00001539
1026 CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 cyclin-dependent kinase inhibitor 1A (p21, Cip1) C00001539
1027 CDKN1B, CDKN4, KIP1, MEN1B, MEN4, P27KIP1 cyclin-dependent kinase inhibitor 1B (p27, Kip1) C00001539
1029 CDKN2A, ARF, CDK4I, CDKN2, CMM2, INK4, INK4A, MLM, MTS-1, MTS1, P14, P14ARF, P16, P16-INK4A, P16INK4, P16INK4A, P19, P19ARF, TP16 cyclin-dependent kinase inhibitor 2A C00001539
1111 CHEK1, CHK1 checkpoint kinase 1 (EC:2.7.11.1) C00001539
27141 CIDEB cell death-inducing DFFA-like effector b C00001539
1047 CLGN calmegin C00001539
1270 CNTF, HCNTF ciliary neurotrophic factor C00001539
1401 CRP, PTX1 C-reactive protein, pentraxin-related C00001539
1499 CTNNB1, CTNNB, MRD19, armadillo catenin (cadherin-associated protein), beta 1, 88kDa C00001539
1075 CTSC, CPPI, DPP-I, DPP1, DPPI, HMS, JP, JPD, PALS, PDON1, PLS cathepsin C (EC:3.4.14.1) C00001539
7913 DEK, D6S231E DEK oncogene C00001539
1719 DHFR, DHFRP1, DYR dihydrofolate reductase (EC:1.5.1.3) C00001539
22943 DKK1, DKK-1, SK dickkopf WNT signaling pathway inhibitor 1 C00001539
1786 DNMT1, ADCADN, AIM, CXXC9, DNMT, HSN1E, MCMT DNA (cytosine-5-)-methyltransferase 1 (EC:2.1.1.37) C00001539
1788 DNMT3A, DNMT3A2, M.HsaIIIA DNA (cytosine-5-)-methyltransferase 3 alpha (EC:2.1.1.37) C00001539
1789 DNMT3B, ICF, ICF1, M.HsaIIIB DNA (cytosine-5-)-methyltransferase 3 beta (EC:2.1.1.37) C00001539
1805 DPT, TRAMP dermatopontin C00001539
1907 EDN2, ET2, PPET2 endothelin 2 C00001539
2051 EPHB6, HEP EPH receptor B6 (EC:2.7.10.1) C00001539
2114 ETS2, ETS2IT1 v-ets avian erythroblastosis virus E26 oncogene homolog 2 C00001539
84668 FAM126A, DRCTNNB1A, HCC, HLD5, HYCC1 family with sequence similarity 126, member A C00001539
355 FAS, ALPS1A, APO-1, APT1, CD95, FAS1, FASTM, TNFRSF6 Fas cell surface death receptor C00001539
2243 FGA, Fib2 fibrinogen alpha chain C00001539
2273 FHL1, FHL-1, FHL1A, FHL1B, FLH1A, KYOT, SLIM, SLIM-1, SLIM1, SLIMMER, XMPMA four and a half LIM domains 1 C00001539
2350 FOLR2, BETA-HFR, FBP, FBP/PL-1, FR-BETA, FR-P3 folate receptor 2 (fetal) C00001539
2356 FPGS folylpolyglutamate synthase (EC:6.3.2.17) C00001539
2512 FTL, NBIA3 ferritin, light polypeptide C00001539
2621 GAS6, AXLLG, AXSF growth arrest-specific 6 C00001539
9518 GDF15, GDF-15, MIC-1, MIC1, NAG-1, PDF, PLAB, PTGFB growth differentiation factor 15 C00001539
79153 GDPD3 glycerophosphodiester phosphodiesterase domain containing 3 C00001539
8836 GGH, GH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) (EC:3.4.19.9) C00001539
2697 GJA1, AVSD3, CMDR, CX43, DFNB38, GJAL, HLHS1, HSS, ODDD gap junction protein, alpha 1, 43kDa C00001539
2875 GPT, AAT1, ALT1, GPT1 glutamic-pyruvate transaminase (alanine aminotransferase) (EC:2.6.1.2) C00001539
2987 GUK1, GMK guanylate kinase 1 (EC:2.7.4.8) C00001539
8739 HRK, DP5, HARAKIRI harakiri, BCL2 interacting protein (contains only BH3 domain) C00001539
27129 HSPB7, cvHSP heat shock 27kDa protein family, member 7 (cardiovascular) C00001539
3397 ID1, ID, bHLHb24 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein C00001539
8519 IFITM1, 9-27, CD225, DSPA2a, IFI17, LEU13 interferon induced transmembrane protein 1 C00001539
10410 IFITM3, 1-8U, DSPA2b, IP15 interferon induced transmembrane protein 3 C00001539
3488 IGFBP5, IBP5 insulin-like growth factor binding protein 5 C00001539
3558 IL2, IL-2, TCGF, lymphokine interleukin 2 C00001539
3576 IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 interleukin 8 C00001539
3638 INSIG1, CL-6, CL6 insulin induced gene 1 C00001539
3675 ITGA3, CD49C, GAP-B3, GAPB3, ILNEB, MSK18, VCA-2, VL3A, VLA3a integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) C00001539
3676 ITGA4, CD49D, IA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) C00001539
3678 ITGA5, CD49e, FNRA, VLA5A integrin, alpha 5 (fibronectin receptor, alpha polypeptide) C00001539
3655 ITGA6, CD49f, ITGA6B, VLA-6 integrin, alpha 6 C00001539
3688 ITGB1, CD29, FNRB, GPIIA, MDF2, MSK12, VLA-BETA, VLAB integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) C00001539
3725 JUN, AP-1, AP1, c-Jun jun proto-oncogene C00001539
9735 KNTC1, ROD kinetochore associated 1 C00001539
3861 KRT14, CK14, EBS3, EBS4, K14, NFJ keratin 14 C00001539
7851 MALL, BENE mal, T-cell differentiation protein-like C00001539
4131 MAP1B, FUTSCH, MAP5 microtubule-associated protein 1B C00001539
5594 MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk mitogen-activated protein kinase 1 (EC:2.7.11.24) C00001539
5595 MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK mitogen-activated protein kinase 3 (EC:2.7.11.24) C00001539
8932 MBD2, DMTase, NY-CO-41 methyl-CpG binding domain protein 2 C00001539
4170 MCL1, BCL2L3, EAT, MCL1-ES, MCL1L, MCL1S, Mcl-1, TM, bcl2-L-3, mcl1/EAT myeloid cell leukemia sequence 1 (BCL2-related) C00001539
4193 MDM2, ACTFS, HDMX, hdm2 MDM2 oncogene, E3 ubiquitin protein ligase C00001539
11343 MGLL, HU-K5, HUK5, MAGL, MGL monoglyceride lipase (EC:3.1.1.23) C00001539
4255 MGMT O-6-methylguanine-DNA methyltransferase (EC:2.1.1.63) C00001539
100507436 MICA, MIC-A, PERB11.1 MHC class I polypeptide-related sequence A C00001539
4282 MIF, GIF, GLIF, MMIF macrophage migration inhibitory factor (glycosylation-inhibiting factor) (EC:5.3.3.12 5.3.2.1) C00001539
4311 MME, CALLA, CD10, NEP, SFE membrane metallo-endopeptidase (EC:3.4.24.11) C00001539
4314 MMP3, CHDS6, MMP-3, SL-1, STMY, STMY1, STR1 matrix metallopeptidase 3 (stromelysin 1, progelatinase) (EC:3.4.24.17) C00001539
4504 MT3, GIF, GIFB, GRIF, ZnMT3 metallothionein 3 C00001539
4552 MTRR, MSR, cblE 5-methyltetrahydrofolate-homocysteine methyltransferase reductase (EC:1.16.1.8) C00001539
4582 MUC1, CA_15-3, CD227, EMA, H23AG, KL-6, MAM6, MCKD1, MUC-1, MUC-1/SEC, MUC-1/X, MUC1/ZD, PEM, PEMT, PUM mucin 1, cell surface associated C00001539
4651 MYO10 myosin X C00001539
4684 NCAM1, CD56, MSK39, NCAM neural cell adhesion molecule 1 (EC:2.7.11.1) C00001539
653361 NCF1, NCF1A, NOXO2, SH3PXD1A, p47phox neutrophil cytosolic factor 1 C00001539
3340 NDST1, HSST, NST1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 (EC:2.8.2.8) C00001539
4790 NFKB1, EBP-1, KBF1, NF-kB1, NF-kappa-B, NF-kappaB, NFKB-p105, NFKB-p50, NFkappaB, p105, p50 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 C00001539
4792 NFKBIA, IKBA, MAD-3, NFKBI nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha C00001539
4833 NME4, NDPK-D, NM23H4, nm23-H4 NME/NM23 nucleoside diphosphate kinase 4 (EC:2.7.4.6) C00001539
4855 NOTCH4, INT3, NOTCH3 notch 4 C00001539
9315 NREP, C5orf13, D4S114, P311, PRO1873, PTZ17, SEZ17 neuronal regeneration related protein C00001539
4913 NTHL1, NTH1, OCTS3 nth endonuclease III-like 1 (E. coli) (EC:4.2.99.18) C00001539
59277 NTN4, PRO3091 netrin 4 C00001539
142 PARP1, ADPRT, ADPRT_1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1 poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) C00001539
26577 PCOLCE2, PCPE2 procollagen C-endopeptidase enhancer 2 C00001539
5154 PDGFA, PDGF-A, PDGF1 platelet-derived growth factor alpha polypeptide C00001539
5204 PFDN5, MM-1, MM1, PFD5 prefoldin subunit 5 C00001539
5230 PGK1, MIG10, PGKA phosphoglycerate kinase 1 (EC:2.7.2.3) C00001539
10424 PGRMC2, DG6, PMBP progesterone receptor membrane component 2 C00001539
5295 PIK3R1, AGM7, GRB1, p85, p85-ALPHA phosphoinositide-3-kinase, regulatory subunit 1 (alpha) C00001539
5111 PCNA proliferating cell nuclear antigen C00007252
5329 PLAUR, CD87, U-PAR, UPAR, URKR plasminogen activator, urokinase receptor C00001539
5420 PODXL, Gp200, PC, PCLP, PCLP-1 podocalyxin-like C00001539
5591 PRKDC, DNA-PKcs, DNAPK, DNPK1, HYRC, HYRC1, XRCC7, p350 protein kinase, DNA-activated, catalytic polypeptide (EC:2.7.11.1) C00001539
51334 PRR16, DSC54 proline rich 16 C00001539
5753 PTK6, BRK protein tyrosine kinase 6 (EC:2.7.10.2) C00001539
83956 RACGAP1P, FKSG42 Rac GTPase activating protein 1 pseudogene C00001539
5894 RAF1, CRAF, NS5, Raf-1, c-Raf v-raf-1 murine leukemia viral oncogene homolog 1 (EC:2.7.11.1) C00001539
5921 RASA1, CM-AVM, CMAVM, GAP, PKWS, RASA, RASGAP, p120GAP, p120RASGAP RAS p21 protein activator (GTPase activating protein) 1 C00001539
8434 RECK, ST15 reversion-inducing-cysteine-rich protein with kazal motifs C00001539
389 RHOC, ARH9, ARHC, H9, RHOH9 ras homolog family member C C00001539
6119 RPA3, REPA3 replication protein A3, 14kDa C00001539
6193 RPS5, S5 ribosomal protein S5 C00001539
6281 S100A10, 42C, ANX2L, ANX2LG, CAL1L, CLP11, Ca[1], GP11, P11, p10 S100 calcium binding protein A10 C00001539
6275 S100A4, 18A2, 42A, CAPL, FSP1, MTS1, P9KA, PEL98 S100 calcium binding protein A4 C00001539
6303 SAT1, DC21, KFSD, KFSDX, SAT, SSAT, SSAT-1 spermidine/spermine N1-acetyltransferase 1 (EC:2.3.1.57) C00001539
5055 SERPINB2, HsT1201, PAI, PAI-2, PAI2, PLANH2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 C00001539
6470 SHMT1, CSHMT, SHMT serine hydroxymethyltransferase 1 (soluble) (EC:2.1.2.1) C00001539
6566 SLC16A1, HHF7, MCT, MCT1 solute carrier family 16 (monocarboxylate transporter), member 1 C00001539
6580 SLC22A1, HOCT1, OCT1, oct1_cds solute carrier family 22 (organic cation transporter), member 1 C00001539
6514 SLC2A2, GLUT2 solute carrier family 2 (facilitated glucose transporter), member 2 C00001539
30061 SLC40A1, FPN1, HFE4, IREG1, MST079, MTP1, SLC11A3 solute carrier family 40 (iron-regulated transporter), member 1 C00001539
9056 SLC7A7, LAT3, LPI, MOP-2, Y+LAT1, y+LAT-1 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7 C00001539
6659 SOX4, EVI16 SRY (sex determining region Y)-box 4 C00001539
6667 SP1 Sp1 transcription factor C00001539
6690 SPINK1, PCTT, PSTI, Spink3, TATI, TCP serine peptidase inhibitor, Kazal type 1 C00001539
6876 TAGLN, SM22, SMCC, TAGLN1, WS3-10 transgelin C00001539
4071 TM4SF1, H-L6, L6, M3S1, TAAL6 transmembrane 4 L six family member 1 C00001539
8795 TNFRSF10B, CD262, DR5, KILLER, KILLER/DR5, TRAIL-R2, TRAILR2, TRICK2, TRICK2A, TRICK2B, TRICKB, ZTNFR9 tumor necrosis factor receptor superfamily, member 10b C00001539
8764 TNFRSF14, ATAR, CD270, HVEA, HVEM, LIGHTR, TR2 tumor necrosis factor receptor superfamily, member 14 C00001539
7157 TP53, BCC7, LFS1, P53, TRP53 tumor protein p53 C00001539
7185 TRAF1, EBI6, MGC:10353 TNF receptor-associated factor 1 C00001539
9618 TRAF4, CART1, MLN62, RNF83 TNF receptor-associated factor 4 C00001539
7189 TRAF6, MGC:3310, RNF85 TNF receptor-associated factor 6, E3 ubiquitin protein ligase C00001539
10293 TRAIP, RNF206, TRIP TRAF interacting protein C00001539
7846 TUBA1A, B-ALPHA-1, LIS3, TUBA3 tubulin, alpha 1a C00001539
55000 TUG1, LINC00080, NCRNA00080, TI-227H taurine up-regulated 1 (non-protein coding) C00001539
10628 TXNIP, EST01027, HHCPA78, THIF, VDUP1 thioredoxin interacting protein C00001539
7298 TYMS, HST422, TMS, TS thymidylate synthetase (EC:2.1.1.45) C00001539
54532 USP53 ubiquitin specific peptidase 53 C00001539
7422 VEGFA, MVCD1, VEGF, VPF vascular endothelial growth factor A C00001539
389136 VGLL3, VGL-3, VGL3 vestigial like 3 (Drosophila) C00001539
8840 WISP1, CCN4, WISP1c, WISP1i, WISP1tc WNT1 inducible signaling pathway protein 1 C00001539
7474 WNT5A, hWNT5A wingless-type MMTV integration site family, member 5A C00001539
51222 ZNF219, ZFP219 zinc finger protein 219 C00001539

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (33)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#117800 Apocrine gland secretion, variation in Q96J66
#614490 Blood group, junior system; jr Q9UNQ0
#114500 Colorectal cancer; crc P11586
P84022
#127750 Dementia, lewy body; dlb P37840
#119900 Digital clubbing, isolated congenital P15428
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#301500 Fabry disease P06280
#608013 Gaucher disease, perinatal lethal P04062
#230800 Gaucher disease, type i P04062
#230900 Gaucher disease, type ii P04062
#231000 Gaucher disease, type iii P04062
#231005 Gaucher disease, type iiic P04062
#232300 Glycogen storage disease ii P10253
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#145000 Hyperparathyroidism 1; hrpt1 O00255
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#601634 Neural tube defects, folate-sensitive P11586
#257200 Niemann-pick disease, type a P17405
#607616 Niemann-pick disease, type b P17405
#168601 Parkinson disease 1, autosomal dominant; park1 P37840
#605543 Parkinson disease 4, autosomal dominant; park4 P37840
#168600 Parkinson disease, late-onset; pd P04062
P37840
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#138900 Uric acid concentration, serum, quantitative trait locus 1; uaqtl1 Q9UNQ0

KEGG DISEASE (28)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00066 Lewy body dementia (LBD) P04062 (related)
P37840 (related)
H00126 Gaucher disease P04062 (related)
H00426 Defects in the degradation of ganglioside P04062 (related)
H00810 Progressive myoclonic epilepsy (PME) P04062 (related)
H00125 Fabry disease P06280 (related)
H00036 Osteosarcoma P08684 (marker)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00262 Spina bifida P11586 (related)
H01205 Coumarin resistance P11712 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00137 Niemann-Pick disease (NPD) typeA and B P17405 (related)
H00424 Defects in the degradation of sphingomyelin P17405 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00057 Parkinson's disease (PD) P37840 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H00063 Spinocerebellar ataxia (SCA) Q9NUW8 (related)

Diseases related to CTD interactions

102 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D001321 Autistic Disorder C00007252
C00001539
D009436 Neural Tube Defects C00007252
C00001539
D009374 Neoplasms, Experimental C00001539
D000014 Abnormalities, Drug-Induced C00001539
D058186 Acute Kidney Injury C00001539
D000236 Adenoma C00001539
D000370 Ageusia C00001539
D000430 Alcohol Withdrawal Delirium C00001539
D000544 Alzheimer Disease C00001539
D000740 Anemia C00001539
D000741 Anemia, Aplastic C00001539
D000743 Anemia, Hemolytic C00001539
D000744 Anemia, Hemolytic, Autoimmune C00001539
D000748 Anemia, Macrocytic C00001539
D000749 Anemia, Megaloblastic C00001539
D000755 Anemia, Sickle Cell C00001539
D000756 Anemia, Sideroblastic C00001539
D000757 Anencephaly C00001539
D001002 Anuria C00001539
D001161 Arteriosclerosis C00001539
D015535 Arthritis, Psoriatic C00001539
D001259 Ataxia C00001539
D001284 Atrophy C00001539
D001714 Bipolar Disorder C00001539
D001925 Brain Damage, Chronic C00001539
D001927 Brain Diseases C00001539
D001943 Breast Neoplasms C00001539
D002292 Carcinoma, Renal Cell C00001539
D018376 Cardiovascular Abnormalities C00001539
D002318 Cardiovascular Diseases C00001539
D002386 Cataract C00001539
D002524 Cerebellar Ataxia C00001539
D002971 Cleft Lip C00001539
D002972 Cleft Palate C00001539
D003072 Cognition Disorders C00001539
D015179 Colorectal Neoplasms C00001539
D003117 Color Vision Defects C00001539
D000013 Congenital Abnormalities C00001539
D023903 Coronary Restenosis C00001539
D003704 Dementia C00001539
D003866 Depressive Disorder C00001539
D003924 Diabetes Mellitus, Type 2 C00001539
D004195 Disease Models, Animal C00001539
D004244 Dizziness C00001539
D056486 Drug-Induced Liver Injury C00001539
D064420 Drug-Related Side Effects and Adverse Reactions C00001539
D016889 Endometrial Neoplasms C00001539
D004827 Epilepsy C00001539
D017889 Exfoliation Syndrome C00001539
D005235 Fatty Liver, Alcoholic C00001539
D063647 Fetal Alcohol Spectrum Disorders C00001539
D005494 Folic Acid Deficiency C00001539
D005756 Gastritis C00001539
D005832 Genital Diseases, Male C00001539
D005901 Glaucoma C00001539
D006261 Headache C00001539
D006330 Heart Defects, Congenital C00001539
D006402 Hematologic Diseases C00001539
D006679 HIV Seropositivity C00001539
D006849 Hydrocephalus C00001539
D020138 HYPERHOMOCYSTEINEMIA C00001539
D006948 Hyperkinesis C00001539
D006973 Hypertension C00001539
D007021 Hypospadias C00001539
D007674 Kidney Diseases C00001539
D007676 Kidney Failure, Chronic C00001539
D007683 Kidney Tubular Necrosis, Acute C00001539
D008107 Liver Diseases C00001539
D008180 Lupus Erythematosus, Systemic C00001539
D016778 Malaria, Falciparum C00001539
D019767 Maxillofacial Abnormalities C00001539
D008545 Melanoma C00001539
D052016 Mucositis C00001539
D009135 Muscular Diseases C00001539
D009303 Nasopharyngeal Neoplasms C00001539
D009369 Neoplasms C00001539
D006712 Homocystinuria C00007252
D009395 Nephritis, Interstitial C00001539
D009422 Nervous System Diseases C00001539
D009503 Neutropenia C00001539
C541083 Non-alcoholic Fatty Liver Disease C00001539
D009901 Optic Nerve Diseases C00001539
D010018 Osteomalacia C00001539
D010523 Peripheral Nervous System Diseases C00001539
D049188 Prenatal Injuries C00001539
D011507 Proteinuria C00001539
D011565 Psoriasis C00001539
D011602 Psychophysiologic Disorders C00001539
D051437 Renal Insufficiency C00001539
D012559 Schizophrenia C00001539
D012607 Scotoma C00001539
D012640 Seizures C00001539
D012851 Sinus Thrombosis, Intracranial C00001539
D012871 Skin Diseases C00001539
D013118 Spinal Cord Diseases C00001539
D016135 Spinal Dysraphism C00001539
D013182 Sprue, Tropical C00001539
D013274 Stomach Neoplasms C00001539
D020521 Stroke C00001539
D013921 Thrombocytopenia C00001539
D014123 Toxoplasmosis C00001539
D014511 Uremia C00001539