KNApSAcK Metabolite C00007252
Metabolite
KNApSAcK Entry
| id | C00007252 |
|---|---|
| Name | 5-Methyl-tetrahydrofolate / 5-Methyltetrahydrofolic acid |
| CAS RN | 134-35-0 |
| Standard InChI | InChI=1S/C20H25N7O6/c1-27-12(9-23-16-15(27)18(31)26-20(21)25-16)8-22-11-4-2-10(3-5-11)17(30)24-13(19(32)33)6-7-14(28)29/h2-5,12-13,22H,6-9H2,1H3,(H,24,30)(H,28,29)(H,32,33)(H4,21,23,25,26,31)/t12?,13-/m1/s1 |
| Standard InChI (Main Layer) | InChI=1S/C20H25N7O6/c1-27-12(9-23-16-15(27)18(31)26-20(21)25-16)8-22-11-4-2-10(3-5-11)17(30)24-13(19(32)33)6-7-14(28)29/h2-5,12-13,22H,6-9H2,1H3,(H,24,30)(H,28,29)(H,32,33)(H4,21,23,25,26,31) |
Cluster
| Phytochemical cluster | |
|---|---|
| KCF-S cluster | No. 1399 |
Link
ChEMBL
| By standard InChI | |
|---|---|
| By standard InChI Main Layer | CHEMBL1221561 CHEMBL1231574 CHEMBL2358502 |
KEGG
| By LinkDB | C00440 |
|---|
CTD
| By CAS RN | C005984 |
|---|
Species
Summary
Plant class
| class name | count |
|---|---|
| rosids | 1 |
Family
| family name | count |
|---|---|
| Brassicaceae | 1 |
List (1)
* NCBI
| KNApSAcK organism | *ID | *family | *plant class | *kingdom |
|---|---|---|---|---|
| Arabidopsis thaliana | 3702 | Brassicaceae | rosids | Viridiplantae |
Human Protein / Gene in interaction
CTD interaction (8)
| compound | gene | gene name | gene description | interaction | interaction type | form |
reference
pmid |
|---|---|---|---|---|---|---|---|
| C005984 | 10840 |
ALDH1L1
10-FTHFDH 10-fTHF FDH FTHFD |
aldehyde dehydrogenase 1 family, member L1 (EC:1.5.1.6) | ALDH1L1 protein results in decreased abundance of 5-methyltetrahydrofolate |
decreases abundance
|
protein |
16627483
|
| C005984 | 2348 |
FOLR1
FBP FOLR |
folate receptor 1 (adult) | FOLR1 protein results in increased uptake of 5-methyltetrahydrofolate |
increases uptake
|
protein |
17473184
|
| C005984 | 4524 |
MTHFR
|
methylenetetrahydrofolate reductase (NAD(P)H) (EC:1.5.1.20) | MTHFR protein results in increased chemical synthesis of 5-methyltetrahydrofolate |
increases chemical synthesis
|
protein |
7647779
9719624 |
| C005984 | 4548 |
MTR
HMAG MS cblG |
5-methyltetrahydrofolate-homocysteine methyltransferase (EC:2.1.1.13) | 5-methyltetrahydrofolate binds to MTR protein |
affects binding
|
protein |
17477549
|
| C005984 | 5111 |
PCNA
|
proliferating cell nuclear antigen | [Docosahexaenoic Acids co-treated with 5-methyltetrahydrofolate] results in increased expression of PCNA protein |
affects cotreatment
/ increases expression |
protein |
16870008
|
| C005984 | 6573 |
SLC19A1
CHMD FOLT IFC1 REFC RFC1 |
solute carrier family 19 (folate transporter), member 1 | [5-methyltetrahydrofolate results in decreased activity of SLC19A1 protein] which results in decreased uptake of Folic Acid |
decreases activity
/ decreases uptake |
protein |
17034785
|
| C005984 | 113235 |
SLC46A1
G21 HCP1 PCFT |
solute carrier family 46 (folate transporter), member 1 | 5-methyltetrahydrofolate inhibits the reaction [SLC46A1 protein results in increased transport of Folic Acid] |
decreases reaction
/ increases transport |
protein |
17475902
|
| C005984 | 113235 |
SLC46A1
G21 HCP1 PCFT |
solute carrier family 46 (folate transporter), member 1 | 5-methyltetrahydrofolate results in decreased activity of SLC46A1 protein |
decreases activity
|
protein |
17475902
|