PCIDB

KNApSAcK Metabolite C00015457

Metabolite

KNApSAcK Entry

id C00015457
Name L 783290
CAS RN 219917-93-8
Standard InChI InChI=1S/C19H24O7/c1-11-5-3-7-14(20)18(23)15(21)8-4-6-12-9-13(25-2)10-16(22)17(12)19(24)26-11/h3,7,9-11,15,18,21-23H,4-6,8H2,1-2H3/b7-3-
Standard InChI (Main Layer) InChI=1S/C19H24O7/c1-11-5-3-7-14(20)18(23)15(21)8-4-6-12-9-13(25-2)10-16(22)17(12)19(24)26-11/h3,7,9-11,15,18,21-23H,4-6,8H2,1-2H3

Cluster

Phytochemical cluster
KCF-S cluster No. 2282

Link

ChEMBL

By standard InChI
By standard InChI Main Layer CHEMBL2012519

KEGG

By LinkDB

CTD

By CAS RN

Species

Summary

Plant class

class name count

Family

family name count
Didymellaceae 1

List (1)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Phoma sp. (ATCC 74403) 37463 Didymellaceae Fungi

Human Protein / Gene in interaction

32 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P08069 Insulin-like growth factor 1 receptor TK tyrosine-protein kinase INSR subfamily CHEMBL2012519 CHEMBL1656529 (1)
1 / 3
Q16539 Mitogen-activated protein kinase 14 p38 CHEMBL2012519 CHEMBL1656541 (1)
0 / 0
Q16512 Serine/threonine-protein kinase N1 Pkn CHEMBL2012519 CHEMBL1656537 (1)
0 / 0
O14965 Aurora kinase A Aur CHEMBL2012519 CHEMBL1656383 (1)
0 / 0
P24941 Cyclin-dependent kinase 2 Cdc2 CHEMBL2012519 CHEMBL1656387 (1)
0 / 0
P43403 Tyrosine-protein kinase ZAP-70 Syk CHEMBL2012519 CHEMBL1656389 (1)
1 / 2
Q9HBH9 MAP kinase-interacting serine/threonine-protein kinase 2 CAMK serine/threonine protein kinase MNK subfamily CHEMBL2012519 CHEMBL1656378 (1)
0 / 0
Q06187 Tyrosine-protein kinase BTK Tec CHEMBL2012519 CHEMBL1656385 (1)
2 / 2
Q16513 Serine/threonine-protein kinase N2 Pkn CHEMBL2012519 CHEMBL1656538 (1)
0 / 0
P23458 Tyrosine-protein kinase JAK1 Jakb CHEMBL2012519 CHEMBL1656531 (1)
0 / 0
P36507 Dual specificity mitogen-activated protein kinase kinase 2 Ste7 CHEMBL2012519 CHEMBL1656376 (1)
1 / 1
P29597 Non-receptor tyrosine-protein kinase TYK2 Jakb CHEMBL2012519 CHEMBL1656381 (1)
1 / 1
P54764 Ephrin type-A receptor 4 Eph CHEMBL2012519 CHEMBL1656391 (1)
0 / 0
P54760 Ephrin type-B receptor 4 Eph CHEMBL2012519 CHEMBL1656373 (1)
0 / 0
P49841 Glycogen synthase kinase-3 beta Gsk CHEMBL2012519 CHEMBL1656526 (1)
0 / 0
Q9UM73 ALK tyrosine kinase receptor TKL serine/threonine protein kinase STKR type 1 subfamily CHEMBL2012519 CHEMBL1656371 (1)
1 / 1
P06213 Insulin receptor TK tyrosine-protein kinase INSR subfamily CHEMBL2012519 CHEMBL1656530 (1)
5 / 4
P04626 Receptor tyrosine-protein kinase erbB-2 TK tyrosine-protein kinase EGFR subfamily CHEMBL2012519 CHEMBL1656527 (1)
5 / 10
O60674 Tyrosine-protein kinase JAK2 Jakb CHEMBL2012519 CHEMBL1656532 (1)
5 / 2
P35968 Vascular endothelial growth factor receptor 2 Vegfr CHEMBL2012519 CHEMBL1656382 (1) CHEMBL1656542 (1)
1 / 0
P08581 Hepatocyte growth factor receptor TK tyrosine-protein kinase MET subfamily CHEMBL2012519 CHEMBL1656528 (1)
2 / 3
P28482 Mitogen-activated protein kinase 1 Erk CHEMBL2012519 CHEMBL1656372 (1)
0 / 0
P22607 Fibroblast growth factor receptor 3 Fgfr CHEMBL2012519 CHEMBL1656525 (1)
14 / 6
Q8IW41 MAP kinase-activated protein kinase 5 CAMK serine/threonine protein kinase MAPKAPK CHEMBL2012519 CHEMBL1656377 (1)
0 / 0
O75116 Rho-associated protein kinase 2 Rock CHEMBL2012519 CHEMBL1656539 (1)
0 / 0
Q15118 [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial Pdhk CHEMBL2012519 CHEMBL1656534 (1)
0 / 0
P07949 Proto-oncogene tyrosine-protein kinase receptor Ret Ret CHEMBL2012519 CHEMBL1656380 (1)
9 / 5
P10721 Mast/stem cell growth factor receptor Kit Pdgfr CHEMBL2012519 CHEMBL1656374 (1)
4 / 4
P06239 Tyrosine-protein kinase Lck Src CHEMBL2012519 CHEMBL1015858 (1) CHEMBL1656375 (1)
0 / 1
P52333 Tyrosine-protein kinase JAK3 Jakb CHEMBL2012519 CHEMBL1656533 (1)
1 / 1
P17612 cAMP-dependent protein kinase catalytic subunit alpha Pka CHEMBL2012519 CHEMBL1656535 (1)
0 / 0
P30530 Tyrosine-protein kinase receptor UFO TK tyrosine-protein kinase AXL subfamily CHEMBL2012519 CHEMBL1656384 (1)
0 / 0

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (51)

OMIM preferred title UniProt
#100800 Achondroplasia; ach P22607
#300755 Agammaglobulinemia, x-linked; xla Q06187
#109800 Bladder cancer P22607
#600880 Budd-chiari syndrome; bdchs O60674
#610474 Camptodactyly, tall stature, and hearing loss syndrome P22607
#615280 Cardiofaciocutaneous syndrome 4; cfc4 P36507
#209880 Central hypoventilation syndrome, congenital; cchs P07949
#603956 Cervical cancer P22607
#114500 Colorectal cancer; crc P07949
#612247 Crouzon syndrome with acanthosis nigricans; can P22607
#610549 Diabetes mellitus, insulin-resistant, with acanthosis nigricans P06213
#125853 Diabetes mellitus, noninsulin-dependent; niddm P06213
#246200 Donohue syndrome P06213
#613659 Gastric cancer P04626
#137215 Gastric cancer, hereditary diffuse; hdgc P04626
#606764 Gastrointestinal stromal tumor; gist P10721
#137800 Glioma susceptibility 1; glm1 P04626
#602089 Hemangioma, capillary infantile P35968
#114550 Hepatocellular carcinoma P08581
#142623 Hirschsprung disease, susceptibility to, 1; hscr1 P07949
#609968 Hyperinsulinemic hypoglycemia, familial, 5; hhf5 P06213
#146000 Hypochondroplasia; hch P22607
#270450 Insulin-like growth factor i, resistance to P08069
#307200 Isolated growth hormone deficiency, type iii; ighd3 Q06187
#182000 Keratosis, seborrheic P22607
#149730 Lacrimoauriculodentodigital syndrome; ladd P22607
#601626 Leukemia, acute myeloid; aml O60674
P10721
#211980 Lung cancer P04626
#602849 Muenke syndrome; mnkes P22607
#171400 Multiple endocrine neoplasia, type iia; men2a P07949
#162300 Multiple endocrine neoplasia, type iib; men2b P07949
#254450 Myelofibrosis O60674
#254500 Myeloma, multiple P22607
#613014 Neuroblastoma, susceptibility to, 3; nblst3 Q9UM73
#162900 Nevus, epidermal P22607
#167000 Ovarian cancer P04626
#171300 Pheochromocytoma P07949
#172800 Piebald trait; pbt P10721
#262190 Pineal hyperplasia, insulin-resistant diabetes mellitus, and somatic abnormalities P06213
#263300 Polycythemia vera; pv O60674
#191830 Renal adysplasia P07949
#605074 Renal cell carcinoma, papillary, 1; rccp1 P08581
#269840 Selective t-cell defect; stcd P43403
#600802 Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-negative P52333
#273300 Testicular germ cell tumor; tgct P10721
P22607
#187600 Thanatophoric dysplasia, type i; td1 P22607
#187601 Thanatophoric dysplasia, type ii; td2 P22607
#614521 Thrombocythemia 3; thcyt3 O60674
#155240 Thyroid carcinoma, familial medullary; mtc P07949
#188550 Thyroid carcinoma, papillary P07949
#611521 Tyrosine kinase 2 deficiency P29597

KEGG DISEASE (38)

KEGG disease name UniProt
H00012 Polycythemia vera O60674 (related)
O60674 (marker)
H00018 Gastric cancer P04626 (related)
P08581 (related)
H00019 Pancreatic cancer P04626 (related)
H00022 Bladder cancer P04626 (related)
P22607 (related)
H00026 Endometrial Cancer P04626 (related)
H00027 Ovarian cancer P04626 (related)
H00028 Choriocarcinoma P04626 (related)
H00030 Cervical cancer P04626 (related)
H00031 Breast cancer P04626 (related)
P04626 (marker)
H00046 Cholangiocarcinoma P04626 (related)
P08581 (related)
H00719 Leprechaunism P06213 (related)
H00942 Rabson-Mendenhall syndrome P06213 (related)
H01228 Insulin-resistant diabetes mellitus with acanthosis nigricans (IRAN) P06213 (related)
H01267 Familial hyperinsulinemic hypoglycemia (HHF) P06213 (related)
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
P43403 (related)
H00032 Thyroid cancer P07949 (related)
P07949 (marker)
H00822 Renal agenesis and Renal adysplasia P07949 (related)
H00910 Hirschsprung disease (HD) P07949 (related)
H00916 Congenital central hypoventilation syndrome (CCHS) P07949 (related)
H00015 Malignant pleural mesothelioma P08069 (related)
H00050 Synovial sarcoma P08069 (related)
H01274 Growth delay due to insulin-like growth factor I resistance P08069 (related)
H00021 Renal cell carcinoma P08581 (related)
H00003 Acute myeloid leukemia (AML) P10721 (related)
P10721 (marker)
H00170 Piebaldism P10721 (related)
H00023 Testicular cancer P10721 (marker)
H00010 Multiple myeloma P22607 (related)
H00458 Craniosynostosis P22607 (related)
H00505 FGFR3-related short limb skeletal dysplasias P22607 (related)
H00642 Lacrimo-auriculo-dento-digital syndrome (LADD) P22607 (related)
H00997 CATSHL syndrome P22607 (related)
H00107 Other well-defined immunodeficiency syndromes P29597 (related)
H00523 Noonan syndrome and related disorders P36507 (related)
H00005 Chronic lymphocytic leukemia (CLL) P43403 (marker)
H00091 T-B+Severe combined immunodeficiencies (SCIDs) P52333 (related)
H00085 Agammaglobulinemias Q06187 (related)
H00254 Pituitary Dwarfism (PD) Q06187 (related)
H00014 Non-small cell lung cancer Q9UM73 (related)