PCIDB

KNApSAcK Metabolite C00001661

Metabolite

KNApSAcK Entry

id C00001661
Name Ryanodine
CAS RN 15662-33-6
Standard InChI InChI=1S/C25H35NO9/c1-12(2)22(31)17(34-16(28)14-7-6-10-26-14)23(32)18(4)11-21(30)19(22,5)25(23,33)24(35-21)15(27)13(3)8-9-20(18,24)29/h6-7,10,12-13,15,17,26-27,29-33H,8-9,11H2,1-5H3/t13-,15+,17+,18-,19-,20-,21-,22+,23+,24+,25+/m0/s1
Standard InChI (Main Layer) InChI=1S/C25H35NO9/c1-12(2)22(31)17(34-16(28)14-7-6-10-26-14)23(32)18(4)11-21(30)19(22,5)25(23,33)24(35-21)15(27)13(3)8-9-20(18,24)29/h6-7,10,12-13,15,17,26-27,29-33H,8-9,11H2,1-5H3

Cluster

Phytochemical cluster No. 10
KCF-S cluster No. 1535

Link

ChEMBL

By standard InChI
By standard InChI Main Layer CHEMBL24179 CHEMBL308183 CHEMBL352124 CHEMBL1486287 CHEMBL1742069

KEGG

By LinkDB C19040

CTD

By CAS RN D012433

Species

Summary

Plant class

class name count
rosids 1
asterids 1

Family

family name count
Salicaceae 1
Loganiaceae 1

List (2)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Ryania speciosa 312404 Salicaceae rosids Viridiplantae
Spigelia anthelmia 61950 Loganiaceae asterids Viridiplantae

Human Protein / Gene in interaction

8 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 CHEMBL1742069 CHEMBL1741321 (1)
1 / 0
P49798 Regulator of G-protein signaling 4 Unclassified protein CHEMBL1486287 CHEMBL1794499 (1)
2 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 CHEMBL1742069 CHEMBL1741325 (1)
0 / 1
P21817 Ryanodine receptor 1 CA CHEMBL308183 CHEMBL352124 CHEMBL658417 (1) CHEMBL803054 (1)
CHEMBL803055 (1) CHEMBL803066 (1)
CHEMBL882162 (1) CHEMBL873120 (1)
4 / 2
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 CHEMBL1742069 CHEMBL1741322 (1)
0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 CHEMBL1742069 CHEMBL1741323 (1)
1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 CHEMBL1742069 CHEMBL1741324 (1)
0 / 1
P10636 Microtubule-associated protein tau Unclassified protein CHEMBL1486287 CHEMBL1614250 (1)
4 / 3

CTD interaction (1)

compound gene gene name gene description interaction interaction type form reference
pmid
D012433 6261 RYR1
CCO
MHS
MHS1
RYDR
RYR
RYR-1
SKRR
ryanodine receptor 1 (skeletal) Triclosan promotes the reaction [Ryanodine binds to RYR1 protein] affects binding
/ increases reaction
protein 18795164

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (12)

OMIM preferred title UniProt
#117000 Central core disease of muscle P21817
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#600274 Frontotemporal dementia; ftd P10636
#145600 Malignant hyperthermia, susceptibility to, 1; mhs1 P21817
#255320 Minicore myopathy with external ophthalmoplegia P21817
#255310 Myopathy, congenital, with fiber-type disproportion; cftd P21817
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636

KEGG DISEASE (8)

KEGG disease name UniProt
H00036 Osteosarcoma P08684 (marker)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H01205 Coumarin resistance P11712 (related)
H00699 Central core disease P21817 (related)
H01310 Multi-minicore disease (MmD) P21817 (related)
H01171 Poor drug metabolism (PM) P33261 (related)

Diseases related to CTD interactions

4 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D001145 D012433 Arrhythmias, Cardiac therapeutic
1319336
D019966 D012433 Substance-Related Disorders therapeutic
21113126
D017180 D012433 Tachycardia, Ventricular therapeutic
8313422
D016171 D012433 Torsades de Pointes therapeutic
7620644