Spigelia anthelmia
Species
KNApSAcK Entry
| Organism name | Spigelia anthelmia |
|---|---|
| Genus | Spigelia |
| Family | Loganiaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Spigelia anthelmia |
|---|---|
| Linked NCBI taxonomy ID | 61950 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Loganiaceae |
|---|---|
| ID | 26468 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | asterids |
|---|---|
| ID | 71274 |
Natural Activity
List (34)
| Species | Activity |
|---|---|
| Spigelia anthelmia L. | Anthelmintic |
| Spigelia anthelmia L. | Antifeedant |
| Spigelia anthelmia L. | Antifeedant |
| Spigelia anthelmia L. | Cardiac |
| Spigelia anthelmia L. | Cardiac |
| Spigelia anthelmia L. | Cardiotonic |
| Spigelia anthelmia L. | Cardiotonic |
| Spigelia anthelmia L. | Cathartic |
| Spigelia anthelmia L. | Hypertensive |
| Spigelia anthelmia L. | Hypertensive |
| Spigelia anthelmia L. | Insecticide |
| Spigelia anthelmia L. | Insectifuge |
| Spigelia anthelmia L. | Larvicide |
| Spigelia anthelmia L. | Narcotic |
| Spigelia anthelmia L. | Narcotic |
| Spigelia anthelmia L. | Nematocide |
| Spigelia anthelmia L. | Ovicide |
| Spigelia anthelmia L. | Paralytic |
| Spigelia anthelmia L. | Poison |
| Spigelia anthelmia L. | Poison |
| Spigelia anthelmia L. | Positive Inotropic |
| Spigelia anthelmia L. | Positive Inotropic |
| Spigelia anthelmia L. | Purgative |
| Spigelia anthelmia L. | Sedative |
| Spigelia anthelmia L. | Sedative |
| Spigelia anthelmia L. | Soporific |
| Spigelia anthelmia L. | Soporific |
| Spigelia anthelmia L. | Tonic |
| Spigelia anthelmia L. | Tonic |
| Spigelia anthelmia L. | toxic |
| Spigelia anthelmia L. | toxic |
| Spigelia anthelmia L. | Tranquilizer |
| Spigelia anthelmia L. | Vermifuge |
| Spigelia anthelmia L. | Vermifuge |
Metabolite list (2)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00001661
|
Ryanodine
|
CHEMBL24179
CHEMBL308183 CHEMBL352124 CHEMBL1486287 CHEMBL1742069 |
D012433
|
8 / 12 / 8 | 1 / 4 | No. 1535 | No. 10 |
|
|
C00036672
|
9-Hydroxy-10-epi-ryanodine
/ 9alpha-Hydroxy-10-epiryanodine |
No. 1535 | No. 10 |
|
Human Protein / Gene in interactions
8 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00001661 | 1 / 0 |
| P49798 | Regulator of G-protein signaling 4 | Unclassified protein | C00001661 | 2 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00001661 | 0 / 1 |
| P21817 | Ryanodine receptor 1 | CA | C00001661 | 4 / 2 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00001661 | 0 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00001661 | 1 / 1 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00001661 | 0 / 1 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00001661 | 4 / 3 |
1 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 6261 | RYR1, CCO, MHS, MHS1, RYDR, RYR, RYR-1, SKRR | ryanodine receptor 1 (skeletal) |
C00001661
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (12)
| OMIM | preferred title | UniProt |
|---|---|---|
| #117000 | Central core disease of muscle |
P21817
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #145600 | Malignant hyperthermia, susceptibility to, 1; mhs1 |
P21817
|
| #255320 | Minicore myopathy with external ophthalmoplegia |
P21817
|
| #255310 | Myopathy, congenital, with fiber-type disproportion; cftd |
P21817
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #172700 | Pick disease of brain |
P10636
|
| #604906 | Schizophrenia 9; sczd9 |
P49798
|
| #181500 | Schizophrenia; sczd |
P49798
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
KEGG DISEASE (8)
| KEGG | name | UniProt |
|---|---|---|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00699 | Central core disease |
P21817
(related)
|
| H01310 | Multi-minicore disease (MmD) |
P21817
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|