PCIDB

KNApSAcK Metabolite C00016708

Metabolite

KNApSAcK Entry

id C00016708
Name ES-242-4
CAS RN 136565-69-0
Standard InChI InChI=1S/C32H34O10/c1-13-29(33)27-19(11-41-13)31(35)23-17(7-15(37-3)9-21(23)39-5)25(27)26-18-8-16(38-4)10-22(40-6)24(18)32(36)20-12-42-14(2)30(34)28(20)26/h7-10,13-14,29-30,33-36H,11-12H2,1-6H3
Standard InChI (Main Layer) InChI=1S/C32H34O10/c1-13-29(33)27-19(11-41-13)31(35)23-17(7-15(37-3)9-21(23)39-5)25(27)26-18-8-16(38-4)10-22(40-6)24(18)32(36)20-12-42-14(2)30(34)28(20)26/h7-10,13-14,29-30,33-36H,11-12H2,1-6H3

Cluster

Phytochemical cluster
KCF-S cluster No. 665

Link

ChEMBL

By standard InChI
By standard InChI Main Layer CHEMBL399293

KEGG

By LinkDB

CTD

By CAS RN

Species

Summary

Plant class

class name count

Family

family name count
Plectosphaerellaceae 1

List (1)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Verticillium sp. SPC-15898 1033978 Plectosphaerellaceae Fungi

Human Protein / Gene in interaction

30 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
Q07820 Induced myeloid leukemia cell differentiation protein Mcl-1 Other cytosolic protein CHEMBL399293 CHEMBL1614529 (1)
0 / 0
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein CHEMBL399293 CHEMBL1738312 (1)
0 / 0
P49798 Regulator of G-protein signaling 4 Unclassified protein CHEMBL399293 CHEMBL1794499 (1)
2 / 0
P06746 DNA polymerase beta Enzyme CHEMBL399293 CHEMBL1614079 (1)
0 / 0
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme CHEMBL399293 CHEMBL1794585 (1)
0 / 0
P37840 Alpha-synuclein Unclassified protein CHEMBL399293 CHEMBL2354282 (1)
4 / 2
P54132 Bloom syndrome protein Enzyme CHEMBL399293 CHEMBL1614067 (1)
1 / 2
P00352 Retinal dehydrogenase 1 Enzyme CHEMBL399293 CHEMBL1614458 (1)
0 / 0
P39748 Flap endonuclease 1 Enzyme CHEMBL399293 CHEMBL1794486 (1)
0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme CHEMBL399293 CHEMBL1738606 (1)
0 / 0
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein CHEMBL399293 CHEMBL2114810 (1)
7 / 3
Q9Y253 DNA polymerase eta Enzyme CHEMBL399293 CHEMBL1794569 (1)
1 / 1
Q9Y468 Lethal(3)malignant brain tumor-like protein 1 Unclassified protein CHEMBL399293 CHEMBL1614280 (1)
0 / 0
P11308 Transcriptional regulator ERG Unclassified protein CHEMBL399293 CHEMBL2114924 (1)
1 / 2
Q03164 Histone-lysine N-methyltransferase 2A Enzyme CHEMBL399293 CHEMBL1614257 (1) CHEMBL1614410 (1)
CHEMBL1614531 (1)
1 / 3
P83916 Chromobox protein homolog 1 Unclassified protein CHEMBL399293 CHEMBL1794401 (1)
0 / 0
Q9UNA4 DNA polymerase iota Enzyme CHEMBL399293 CHEMBL1794483 (1)
0 / 0
O75164 Lysine-specific demethylase 4A Enzyme CHEMBL399293 CHEMBL1737991 (1)
0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme CHEMBL399293 CHEMBL1614211 (1)
0 / 0
P10636 Microtubule-associated protein tau Unclassified protein CHEMBL399293 CHEMBL1614421 (1) CHEMBL1614502 (1)
4 / 3
Q9UBT6 DNA polymerase kappa Enzyme CHEMBL399293 CHEMBL1794536 (1)
0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme CHEMBL399293 CHEMBL1613914 (1)
0 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme CHEMBL399293 CHEMBL1613829 (1)
0 / 0
O00255 Menin Unclassified protein CHEMBL399293 CHEMBL1614257 (1) CHEMBL1614531 (1)
2 / 5
Q02410 Amyloid beta A4 precursor protein-binding family A member 1 Unclassified protein CHEMBL399293 CHEMBL1614128 (1) CHEMBL1614304 (1)
0 / 0
Q00975 Voltage-dependent N-type calcium channel subunit alpha-1B N-TYPE CHEMBL399293 CHEMBL1614128 (1) CHEMBL1614304 (1)
0 / 0
Q9UBT2 SUMO-activating enzyme subunit 2 Enzyme CHEMBL399293 CHEMBL1614105 (1) CHEMBL1614290 (1)
0 / 0
Q9UBE0 SUMO-activating enzyme subunit 1 Unclassified protein CHEMBL399293 CHEMBL1614105 (1) CHEMBL1614290 (1)
0 / 0
O94925 Glutaminase kidney isoform, mitochondrial Enzyme CHEMBL399293 CHEMBL2114738 (1)
0 / 0
Q14191 Werner syndrome ATP-dependent helicase Enzyme CHEMBL399293 CHEMBL2114796 (1)
2 / 1

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (25)

OMIM preferred title UniProt
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#210900 Bloom syndrome; blm P54132
#114500 Colorectal cancer; crc Q14191
#127750 Dementia, lewy body; dlb P37840
#612219 Ewing sarcoma; es P11308
#600274 Frontotemporal dementia; ftd P10636
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#145000 Hyperparathyroidism 1; hrpt1 O00255
#174800 Mccune-albright syndrome; mas P63092
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#166350 Osseous heteroplasia, progressive; poh P63092
#168601 Parkinson disease 1, autosomal dominant; park1 P37840
#605543 Parkinson disease 4, autosomal dominant; park4 P37840
#168600 Parkinson disease, late-onset; pd P37840
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#102200 Pituitary adenoma, growth hormone-secreting P63092
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#277700 Werner syndrome; wrn Q14191
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (20)

KEGG disease name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00024 Prostate cancer P11308 (related)
H00035 Ewing's sarcoma P11308 (related)
H00057 Parkinson's disease (PD) P37840 (related)
H00066 Lewy body dementia (LBD) P37840 (related)
H00094 DNA repair defects P54132 (related)
H00296 Defects in RecQ helicases P54132 (related)
Q14191 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)