PCIDB

KNApSAcK Metabolite C00016874

Metabolite

KNApSAcK Entry

id C00016874
Name Dephostatin
CAS RN 151606-30-3
Standard InChI InChI=1S/C7H8N2O3/c1-9(8-12)6-4-5(10)2-3-7(6)11/h2-4,10-11H,1H3
Standard InChI (Main Layer) InChI=1S/C7H8N2O3/c1-9(8-12)6-4-5(10)2-3-7(6)11/h2-4,10-11H,1H3

Cluster

Phytochemical cluster
KCF-S cluster No. 5861

Link

ChEMBL

By standard InChI CHEMBL269733
By standard InChI Main Layer CHEMBL269733

KEGG

By LinkDB

CTD

By CAS RN C084037

Species

Summary

Plant class

class name count

Family

family name count
Streptomycetaceae 1

List (1)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Streptomyces sp. MJ742-NF5 1883 Streptomycetaceae Bacteria

Human Protein / Gene in interaction

50 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 CHEMBL269733 CHEMBL1614110 (1) CHEMBL1741321 (1)
1 / 0
P42345 Serine/threonine-protein kinase mTOR Enzyme CHEMBL269733 CHEMBL1614316 (1) CHEMBL1613805 (1)
CHEMBL1614009 (1)
0 / 0
P18031 Tyrosine-protein phosphatase non-receptor type 1 Tyr CHEMBL269733 CHEMBL772563 (1) CHEMBL772564 (1)
CHEMBL770115 (1)
0 / 0
Q99700 Ataxin-2 Unclassified protein CHEMBL269733 CHEMBL1794367 (1) CHEMBL2114784 (1)
1 / 1
P49798 Regulator of G-protein signaling 4 Unclassified protein CHEMBL269733 CHEMBL1794499 (2)
2 / 0
P14618 Pyruvate kinase PKM Enzyme CHEMBL269733 CHEMBL1614177 (1) CHEMBL1614265 (1)
0 / 0
P06746 DNA polymerase beta Enzyme CHEMBL269733 CHEMBL1614079 (1)
0 / 0
P29466 Caspase-1 C14 CHEMBL269733 CHEMBL1614158 (1)
0 / 0
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme CHEMBL269733 CHEMBL1794585 (1)
0 / 0
O75604 Ubiquitin carboxyl-terminal hydrolase 2 Enzyme CHEMBL269733 CHEMBL1614331 (1)
0 / 0
P02545 Prelamin-A/C Unclassified protein CHEMBL269733 CHEMBL1614544 (1)
11 / 10
O14924 Regulator of G-protein signaling 12 Unclassified protein CHEMBL269733 CHEMBL1613902 (1)
0 / 0
P37840 Alpha-synuclein Unclassified protein CHEMBL269733 CHEMBL2354282 (2)
4 / 2
P10828 Thyroid hormone receptor beta NR1A2 CHEMBL269733 CHEMBL1614554 (1) CHEMBL1613776 (1)
3 / 1
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 CHEMBL269733 CHEMBL1614027 (1) CHEMBL1741325 (1)
0 / 1
P54132 Bloom syndrome protein Enzyme CHEMBL269733 CHEMBL1614522 (1) CHEMBL1614067 (1)
1 / 2
Q9NR56 Muscleblind-like protein 1 Unclassified protein CHEMBL269733 CHEMBL1614166 (1)
1 / 0
P11473 Vitamin D3 receptor NR1I1 CHEMBL269733 CHEMBL1794311 (2)
2 / 3
P00352 Retinal dehydrogenase 1 Enzyme CHEMBL269733 CHEMBL1614458 (1)
0 / 0
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor CHEMBL269733 CHEMBL1614456 (1) CHEMBL1613803 (1)
0 / 0
P39748 Flap endonuclease 1 Enzyme CHEMBL269733 CHEMBL1613922 (1) CHEMBL1794486 (2)
0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme CHEMBL269733 CHEMBL1738606 (1)
0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein CHEMBL269733 CHEMBL1794584 (1)
2 / 0
P38398 Breast cancer type 1 susceptibility protein Enzyme CHEMBL269733 CHEMBL1614303 (1) CHEMBL1613817 (1)
4 / 2
Q9Y253 DNA polymerase eta Enzyme CHEMBL269733 CHEMBL1794569 (1)
1 / 1
P83916 Chromobox protein homolog 1 Unclassified protein CHEMBL269733 CHEMBL1738610 (1) CHEMBL1794401 (1)
0 / 0
P11021 78 kDa glucose-regulated protein Unclassified protein CHEMBL269733 CHEMBL1963893 (1)
0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 CHEMBL269733 CHEMBL1741322 (1)
0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme CHEMBL269733 CHEMBL1613910 (1) CHEMBL1614227 (1)
3 / 3
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme CHEMBL269733 CHEMBL1614038 (1)
2 / 2
Q01453 Peripheral myelin protein 22 Unclassified protein CHEMBL269733 CHEMBL1614171 (1)
5 / 2
P19838 Nuclear factor NF-kappa-B p105 subunit Transcription Factor CHEMBL269733 CHEMBL1614274 (1) CHEMBL1613823 (1)
0 / 0
P16050 Arachidonate 15-lipoxygenase Enzyme CHEMBL269733 CHEMBL1614240 (1)
0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 CHEMBL269733 CHEMBL1613777 (1) CHEMBL1741323 (1)
1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 CHEMBL269733 CHEMBL1741324 (1)
0 / 1
Q9UNA4 DNA polymerase iota Enzyme CHEMBL269733 CHEMBL1794483 (2)
0 / 0
O75164 Lysine-specific demethylase 4A Enzyme CHEMBL269733 CHEMBL1737991 (1)
0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme CHEMBL269733 CHEMBL1614283 (1) CHEMBL1614466 (1)
CHEMBL1614211 (1)
0 / 0
P10636 Microtubule-associated protein tau Unclassified protein CHEMBL269733 CHEMBL1614250 (1) CHEMBL1614421 (1)
CHEMBL1614502 (1)
4 / 3
Q99549 M-phase phosphoprotein 8 Unclassified protein CHEMBL269733 CHEMBL1738402 (2)
0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein CHEMBL269733 CHEMBL1737980 (1)
0 / 0
Q9UBT6 DNA polymerase kappa Enzyme CHEMBL269733 CHEMBL1794536 (1)
0 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme CHEMBL269733 CHEMBL1614330 (1) CHEMBL1613829 (1)
0 / 0
P40225 Thrombopoietin Unclassified protein CHEMBL269733 CHEMBL1614086 (1) CHEMBL1614034 (1)
1 / 1
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme CHEMBL269733 CHEMBL1738442 (2)
0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme CHEMBL269733 CHEMBL1614364 (1)
1 / 1
O00255 Menin Unclassified protein CHEMBL269733 CHEMBL1614257 (1)
2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme CHEMBL269733 CHEMBL1614257 (1)
1 / 3
Q13951 Core-binding factor subunit beta Unclassified protein CHEMBL269733 CHEMBL1738444 (1)
0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein CHEMBL269733 CHEMBL1738444 (1)
1 / 6

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (54)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#210900 Bloom syndrome; blm P54132
#114480 Breast cancer P38398
#604370 Breast-ovarian cancer, familial, susceptibility to, 1; brovca1 P38398
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#118300 Charcot-marie-tooth disease and deafness Q01453
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#118220 Charcot-marie-tooth disease, demyelinating, type 1a; cmt1a Q01453
#114500 Colorectal cancer; crc P84022
#127750 Dementia, lewy body; dlb P37840
#119900 Digital clubbing, isolated congenital P15428
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#600274 Frontotemporal dementia; ftd P10636
#139393 Guillain-barre syndrome, familial; gbs Q01453
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#145000 Hyperparathyroidism 1; hrpt1 O00255
#145900 Hypertrophic neuropathy of dejerine-sottas Q01453
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#162500 Neuropathy, hereditary, with liability to pressure palsies; hnpp Q01453
#167000 Ovarian cancer P38398
#614320 Pancreatic cancer, susceptibility to, 4; pnca4 P38398
#168601 Parkinson disease 1, autosomal dominant; park1 P37840
#605543 Parkinson disease 4, autosomal dominant; park4 P37840
#168600 Parkinson disease, late-onset; pd P37840
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#275210 Restrictive dermopathy, lethal P02545
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#187950 Thrombocythemia 1; thcyt1 P40225
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (45)

KEGG disease name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
Q01453 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00036 Osteosarcoma P08684 (marker)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H01205 Coumarin resistance P11712 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00057 Parkinson's disease (PD) P37840 (related)
H00066 Lewy body dementia (LBD) P37840 (related)
H00027 Ovarian cancer P38398 (related)
H00031 Breast cancer P38398 (related)
H00227 Congenital amegakaryocytic thrombocytopenia (CAMT) P40225 (marker)
H00094 DNA repair defects P54132 (related)
H00296 Defects in RecQ helicases P54132 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H01296 Hereditary neuropathy with liability to pressure palsies (HNPP) Q01453 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
Q9NUW8 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)