Streptomyces sp. MJ742-NF5
Species
KNApSAcK Entry
| Organism name | Streptomyces sp. MJ742-NF5 |
|---|---|
| Genus | Streptomyces |
| Family | Streptomycetaceae |
| Kingdom | Bacteria |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Streptomyces |
|---|---|
| Linked NCBI taxonomy ID | 1883 |
| Linked level | genus |
Family
| Family in NCBI taxonomy | Streptomycetaceae |
|---|---|
| ID | 2062 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Bacteria |
|---|---|
| ID | 2 |
Plant class
| Plant class | |
|---|---|
| ID |
Metabolite list (1)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00016874
|
Dephostatin
|
CHEMBL269733
|
C084037
|
50 / 54 / 45 | No. 5861 |
|
Human Protein / Gene in interactions
50 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00016874 | 1 / 0 |
| P42345 | Serine/threonine-protein kinase mTOR | Enzyme | C00016874 | 0 / 0 |
| P18031 | Tyrosine-protein phosphatase non-receptor type 1 | Tyr | C00016874 | 0 / 0 |
| Q99700 | Ataxin-2 | Unclassified protein | C00016874 | 1 / 1 |
| P49798 | Regulator of G-protein signaling 4 | Unclassified protein | C00016874 | 2 / 0 |
| P14618 | Pyruvate kinase PKM | Enzyme | C00016874 | 0 / 0 |
| P06746 | DNA polymerase beta | Enzyme | C00016874 | 0 / 0 |
| P29466 | Caspase-1 | C14 | C00016874 | 0 / 0 |
| Q13526 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Enzyme | C00016874 | 0 / 0 |
| O75604 | Ubiquitin carboxyl-terminal hydrolase 2 | Enzyme | C00016874 | 0 / 0 |
| P02545 | Prelamin-A/C | Unclassified protein | C00016874 | 11 / 10 |
| O14924 | Regulator of G-protein signaling 12 | Unclassified protein | C00016874 | 0 / 0 |
| P37840 | Alpha-synuclein | Unclassified protein | C00016874 | 4 / 2 |
| P10828 | Thyroid hormone receptor beta | NR1A2 | C00016874 | 3 / 1 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00016874 | 0 / 1 |
| P54132 | Bloom syndrome protein | Enzyme | C00016874 | 1 / 2 |
| Q9NR56 | Muscleblind-like protein 1 | Unclassified protein | C00016874 | 1 / 0 |
| P11473 | Vitamin D3 receptor | NR1I1 | C00016874 | 2 / 3 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00016874 | 0 / 0 |
| Q16665 | Hypoxia-inducible factor 1-alpha | Transcription Factor | C00016874 | 0 / 0 |
| P39748 | Flap endonuclease 1 | Enzyme | C00016874 | 0 / 0 |
| Q92830 | Histone acetyltransferase KAT2A | Enzyme | C00016874 | 0 / 0 |
| P84022 | Mothers against decapentaplegic homolog 3 | Unclassified protein | C00016874 | 2 / 0 |
| P38398 | Breast cancer type 1 susceptibility protein | Enzyme | C00016874 | 4 / 2 |
| Q9Y253 | DNA polymerase eta | Enzyme | C00016874 | 1 / 1 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00016874 | 0 / 0 |
| P11021 | 78 kDa glucose-regulated protein | Unclassified protein | C00016874 | 0 / 0 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00016874 | 0 / 0 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | C00016874 | 3 / 3 |
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | C00016874 | 2 / 2 |
| Q01453 | Peripheral myelin protein 22 | Unclassified protein | C00016874 | 5 / 2 |
| P19838 | Nuclear factor NF-kappa-B p105 subunit | Transcription Factor | C00016874 | 0 / 0 |
| P16050 | Arachidonate 15-lipoxygenase | Enzyme | C00016874 | 0 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00016874 | 1 / 1 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00016874 | 0 / 1 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00016874 | 0 / 0 |
| O75164 | Lysine-specific demethylase 4A | Enzyme | C00016874 | 0 / 0 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00016874 | 0 / 0 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00016874 | 4 / 3 |
| Q99549 | M-phase phosphoprotein 8 | Unclassified protein | C00016874 | 0 / 0 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00016874 | 0 / 0 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00016874 | 0 / 0 |
| P46063 | ATP-dependent DNA helicase Q1 | Enzyme | C00016874 | 0 / 0 |
| P40225 | Thrombopoietin | Unclassified protein | C00016874 | 1 / 1 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00016874 | 0 / 0 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00016874 | 1 / 1 |
| O00255 | Menin | Unclassified protein | C00016874 | 2 / 5 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00016874 | 1 / 2 |
| Q13951 | Core-binding factor subunit beta | Unclassified protein | C00016874 | 0 / 1 |
| Q01196 | Runt-related transcription factor 1 | Unclassified protein | C00016874 | 1 / 4 |
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (54)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #210900 | Bloom syndrome; blm |
P54132
|
| #114480 | Breast cancer |
P38398
|
| #604370 | Breast-ovarian cancer, familial, susceptibility to, 1; brovca1 |
P38398
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #118300 | Charcot-marie-tooth disease and deafness |
Q01453
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #118220 | Charcot-marie-tooth disease, demyelinating, type 1a; cmt1a |
Q01453
|
| #114500 | Colorectal cancer; crc |
P84022
|
| #127750 | Dementia, lewy body; dlb |
P37840
|
| #119900 | Digital clubbing, isolated congenital |
P15428
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #139393 | Guillain-barre syndrome, familial; gbs |
Q01453
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #145900 | Hypertrophic neuropathy of dejerine-sottas |
Q01453
|
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 |
P15428
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #613795 | Loeys-dietz syndrome, type 3; lds3 |
P84022
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
| #160900 | Myotonic dystrophy 1; dm1 |
Q9NR56
|
| #162500 | Neuropathy, hereditary, with liability to pressure palsies; hnpp |
Q01453
|
| #167000 | Ovarian cancer |
P38398
|
| #614320 | Pancreatic cancer, susceptibility to, 4; pnca4 |
P38398
|
| #168601 | Parkinson disease 1, autosomal dominant; park1 |
P37840
|
| #605543 | Parkinson disease 4, autosomal dominant; park4 |
P37840
|
| #168600 | Parkinson disease, late-onset; pd |
P37840
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #172700 | Pick disease of brain |
P10636
|
| #601399 | Platelet disorder, familial, with associated myeloid malignancy |
Q01196
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #604906 | Schizophrenia 9; sczd9 |
P49798
|
| #181500 | Schizophrenia; sczd |
P49798
|
| #183090 | Spinocerebellar ataxia 2; sca2 |
Q99700
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #187950 | Thrombocythemia 1; thcyt1 |
P40225
|
| #188570 | Thyroid hormone resistance, generalized, autosomal dominant; grth |
P10828
|
| #274300 | Thyroid hormone resistance, generalized, autosomal recessive; grth |
P10828
|
| #145650 | Thyroid hormone resistance, selective pituitary; prth |
P10828
|
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
| #278750 | Xeroderma pigmentosum, variant type; xpv |
Q9Y253
|
KEGG DISEASE (45)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
|
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
Q01453 (related) |
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00249 | Thyroid hormone resistance syndrome |
P10828
(related)
|
| H00342 | Tuberculosis |
P11473
(related)
|
| H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
| H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00457 | Primary hypertrophic osteoarthropathy (PHO) |
P15428
(related)
|
| H01246 | Isolated congenital nail clubbing (ICNC) |
P15428
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00057 | Parkinson's disease (PD) |
P37840
(related)
|
| H00066 | Lewy body dementia (LBD) |
P37840
(related)
|
| H00027 | Ovarian cancer |
P38398
(related)
|
| H00031 | Breast cancer |
P38398
(related)
|
| H00227 | Congenital amegakaryocytic thrombocytopenia (CAMT) |
P40225
(marker)
|
| H00094 | DNA repair defects |
P54132
(related)
|
| H00296 | Defects in RecQ helicases |
P54132
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q01196
(related)
Q01196 (marker) Q03164 (related) Q03164 (marker) |
| H00003 | Acute myeloid leukemia (AML) |
Q01196
(related)
Q01196 (marker) Q13951 (marker) |
| H00004 | Chronic myeloid leukemia (CML) |
Q01196
(related)
|
| H00978 | Thrombocytopenia (THC) |
Q01196
(related)
|
| H01296 | Hereditary neuropathy with liability to pressure palsies (HNPP) |
Q01453
(related)
|
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q99700
(related)
Q9NUW8 (related) |
| H00480 | Non-syndromic X-linked mental retardation |
Q99714
(related)
|
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|
| H00403 | Disorders of nucleotide excision repair |
Q9Y253
(related)
|