PCIDB

KNApSAcK Metabolite C00017067

Index

Metabolite

Species

Human Protein
/ Gene in interactions

Related Diseases

Metabolite

KNApSAcK Entry

id	C00017067
Name	Lactacystin / (+)-Lactacystin
CAS RN	133343-34-7
Standard InChI	InChI=1S/C15H24N2O7S/c1-6(2)10(19)15(11(20)7(3)12(21)17-15)14(24)25-5-9(13(22)23)16-8(4)18/h6-7,9-11,19-20H,5H2,1-4H3,(H,16,18)(H,17,21)(H,22,23)/t7-,9+,10-,11+,15-/m1/s1
Standard InChI (Main Layer)	InChI=1S/C15H24N2O7S/c1-6(2)10(19)15(11(20)7(3)12(21)17-15)14(24)25-5-9(13(22)23)16-8(4)18/h6-7,9-11,19-20H,5H2,1-4H3,(H,16,18)(H,17,21)(H,22,23)

Cluster

Phytochemical cluster
KCF-S cluster	No. 6826

Link

ChEMBL

By standard InChI
By standard InChI Main Layer	CHEMBL374308

KEGG

By LinkDB

CTD

By CAS RN	C067713

Species

Summary

Plant class

class name	count

Family

family name	count
Streptomycetaceae	1

List (1)

* NCBI

KNApSAcK organism	*ID	*family	*plant class	*kingdom
Streptomyces sp. OM-6519	1883	Streptomycetaceae		Bacteria

Human Protein / Gene in interaction

3 ChEMBL Protein in interactions

accession	description	class description	compound	assay ID (# of activities)	# of diseases (OMIM / KEGG)
P28062	Proteasome subunit beta type-8	T1A	CHEMBL374308	CHEMBL2343622 (1)	1 / 0
Q15393	Splicing factor 3B subunit 3	Unclassified protein	CHEMBL374308	CHEMBL1243662 (1) CHEMBL1243663 (1) CHEMBL1243666 (1) CHEMBL1243677 (1) CHEMBL1243914 (1)	0 / 0
P28074	Proteasome subunit beta type-5	T1A	CHEMBL374308	CHEMBL2343624 (1) CHEMBL2352040 (1)	0 / 0

CTD interaction (70)

compound	gene	gene name	gene description	interaction	interaction type	form	reference pmid
C067713	196	AHR bHLHe76	aryl hydrocarbon receptor	lactacystin inhibits the reaction [Tetrachlorodibenzodioxin results in increased degradation of AHR protein]	decreases reaction / increases degradation	protein	17445780
C067713	338	APOB FLDB LDLCQ4	apolipoprotein B	acetylleucyl-leucyl-norleucinal inhibits the reaction [lactacystin results in decreased expression of and results in decreased secretion of APOB protein]	decreases expression / decreases reaction / decreases secretion	protein	19383982
C067713	338	APOB FLDB LDLCQ4	apolipoprotein B	HSPA5 promotes the reaction [lactacystin results in increased expression of APOB protein]	increases expression / increases reaction	protein	15618547
C067713	338	APOB FLDB LDLCQ4	apolipoprotein B	HSPA5 promotes the reaction [lactacystin results in increased secretion of APOB protein]	increases reaction / increases secretion	protein	15618547
C067713	338	APOB FLDB LDLCQ4	apolipoprotein B	lactacystin inhibits the reaction [HSPA5 results in increased degradation of APOB protein]	decreases reaction / increases degradation	protein	15618547
C067713	338	APOB FLDB LDLCQ4	apolipoprotein B	lactacystin results in increased expression of and results in increased secretion of APOB protein	increases expression / increases secretion	protein	19383982
C067713	338	APOB FLDB LDLCQ4	apolipoprotein B	lactacystin results in increased expression of APOB protein	increases expression	protein	15618547
C067713	338	APOB FLDB LDLCQ4	apolipoprotein B	lactacystin results in increased secretion of APOB protein	increases secretion	protein	15618547
C067713	351	APP AAA ABETA ABPP AD1 APPI CTFgamma CVAP PN-II PN2	amyloid beta (A4) precursor protein	lactacystin inhibits the reaction [resveratrol results in decreased secretion of APP protein]	decreases reaction / decreases secretion	protein	16162502
C067713	596	BCL2 Bcl-2 PPP1R50	B-cell CLL/lymphoma 2	lactacystin inhibits the reaction [sodium bichromate results in decreased expression of BCL2 protein]	decreases expression / decreases reaction	protein	18544562
C067713	595	CCND1 BCL1 D11S287E PRAD1 U21B31	cyclin D1	lactacystin inhibits the reaction [Curcumin results in increased degradation of CCND1 protein]	decreases reaction / increases degradation	protein	18156803
C067713	898	CCNE1 CCNE	cyclin E1	lactacystin inhibits the reaction [Curcumin results in increased degradation of CCNE1 protein]	decreases reaction / increases degradation	protein	18156803
C067713	1027	CDKN1B CDKN4 KIP1 MEN1B MEN4 P27KIP1	cyclin-dependent kinase inhibitor 1B (p27, Kip1)	lactacystin inhibits the reaction [Estradiol results in increased degradation of CDKN1B protein]	decreases reaction / increases degradation	protein	17283133 23029392
C067713	1027	CDKN1B CDKN4 KIP1 MEN1B MEN4 P27KIP1	cyclin-dependent kinase inhibitor 1B (p27, Kip1)	lactacystin results in increased expression of CDKN1B protein	increases expression	protein	12149143
C067713	1051	CEBPB C/EBP-beta CRP2 IL6DBP LAP LIP NF-IL6 TCF5	CCAAT/enhancer binding protein (C/EBP), beta	lactacystin results in increased expression of CEBPB protein	increases expression	protein	11779194
C067713	1052	CEBPD C/EBP-delta CELF CRP3 NF-IL6-beta	CCAAT/enhancer binding protein (C/EBP), delta	lactacystin results in increased expression of CEBPD protein	increases expression	protein	11779194
C067713	1312	COMT	catechol-O-methyltransferase (EC:2.1.1.6)	lactacystin inhibits the reaction [TNF protein results in increased expression of COMT protein]	decreases reaction / increases expression	protein	17138778
C067713	1499	CTNNB1 CTNNB MRD19 armadillo	catenin (cadherin-associated protein), beta 1, 88kDa	lactacystin inhibits the reaction [Indomethacin results in decreased expression of CTNNB1 protein]	decreases expression / decreases reaction	protein	11756231
C067713	1649	DDIT3 CEBPZ CHOP CHOP-10 CHOP10 GADD153	DNA-damage-inducible transcript 3	lactacystin results in increased expression of DDIT3 mRNA	increases expression	mRNA	19135031
C067713	1734	DIO2 5DII D2 DIOII SelY TXDI2	deiodinase, iodothyronine, type II (EC:1.97.1.10)	lactacystin inhibits the reaction [Cycloheximide results in decreased activity of DIO2 protein]	decreases activity / decreases reaction	protein	11425850
C067713	1734	DIO2 5DII D2 DIOII SelY TXDI2	deiodinase, iodothyronine, type II (EC:1.97.1.10)	lactacystin inhibits the reaction [Thyroxine results in decreased activity of DIO2 protein]	decreases activity / decreases reaction	protein	11425850
C067713	1734	DIO2 5DII D2 DIOII SelY TXDI2	deiodinase, iodothyronine, type II (EC:1.97.1.10)	lactacystin results in increased expression of and results in increased activity of DIO2 protein	increases activity / increases expression	protein	11425850
C067713	1977	EIF4E AUTS19 CBP EIF4E1 EIF4EL1 EIF4F	eukaryotic translation initiation factor 4E	lactacystin inhibits the reaction [Cadmium Chloride results in decreased expression of EIF4E protein]	decreases expression / decreases reaction	protein	15878868
C067713	51343	FZR1 CDC20C CDH1 FZR FZR2 HCDH HCDH1	fizzy/cell division cycle 20 related 1 (Drosophila)	lactacystin inhibits the reaction [Estradiol affects the localization of FZR1 protein]	affects localization / decreases reaction	protein	23029392
C067713	2744	GLS AAD20 GAC GAM GLS1 KGA	glutaminase (EC:3.5.1.2)	lactacystin inhibits the reaction [diphenylarsinic acid results in increased degradation of GLS protein alternative form]	decreases reaction / increases degradation	protein	22493432
C067713	2939	GSTA2 GST2 GSTA2-2 GTA2 GTH2	glutathione S-transferase alpha 2 (EC:2.5.1.18)	lactacystin results in increased expression of GSTA2 mRNA	increases expression	mRNA	12446695
C067713	3091	HIF1A HIF-1A HIF-1alpha HIF1 HIF1-ALPHA MOP1 PASD8 bHLHe78	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	lactacystin inhibits the reaction [geldanamycin results in increased degradation of HIF1A protein]	decreases reaction / increases degradation	protein	11980636
C067713	3297	HSF1 HSTF1	heat shock transcription factor 1	lactacystin results in increased activity of HSF1 protein	increases activity	protein	11893605
C067713	3298	HSF2 HSF_2 HSTF_2	heat shock transcription factor 2	lactacystin results in increased activity of HSF2 protein	increases activity	protein	11893605
C067713	3309	HSPA5 BIP GRP78 MIF2	heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	HSPA5 promotes the reaction [lactacystin results in increased expression of APOB protein]	increases expression / increases reaction		15618547
C067713	3309	HSPA5 BIP GRP78 MIF2	heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	HSPA5 promotes the reaction [lactacystin results in increased secretion of APOB protein]	increases reaction / increases secretion		15618547
C067713	3309	HSPA5 BIP GRP78 MIF2	heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	lactacystin inhibits the reaction [HSPA5 results in increased degradation of APOB protein]	decreases reaction / increases degradation		15618547
C067713	3569	IL6 BSF2 HGF HSF IFNB2 IL-6	interleukin 6 (interferon, beta 2)	lactacystin results in increased expression of IL6 mRNA	increases expression	mRNA	11893605
C067713	3569	IL6 BSF2 HGF HSF IFNB2 IL-6	interleukin 6 (interferon, beta 2)	lactacystin results in increased expression of IL6 protein	increases expression	protein	11893605
C067713	3569	IL6 BSF2 HGF HSF IFNB2 IL-6	interleukin 6 (interferon, beta 2)	Quercetin inhibits the reaction [lactacystin results in increased expression of IL6 mRNA]	decreases reaction / increases expression	mRNA	11893605
C067713	3569	IL6 BSF2 HGF HSF IFNB2 IL-6	interleukin 6 (interferon, beta 2)	Quercetin inhibits the reaction [lactacystin results in increased expression of IL6 protein]	decreases reaction / increases expression	protein	11893605
C067713	3576	IL8 CXCL8 GCP-1 GCP1 LECT LUCT LYNAP MDNCF MONAP NAF NAP-1 NAP1	interleukin 8	Acetylcysteine inhibits the reaction [lactacystin results in increased expression of IL8 mRNA]	decreases reaction / increases expression	mRNA	12208513
C067713	3576	IL8 CXCL8 GCP-1 GCP1 LECT LUCT LYNAP MDNCF MONAP NAF NAP-1 NAP1	interleukin 8	Antimycin A inhibits the reaction [lactacystin results in increased expression of IL8 mRNA]	decreases reaction / increases expression	mRNA	12208513
C067713	3576	IL8 CXCL8 GCP-1 GCP1 LECT LUCT LYNAP MDNCF MONAP NAF NAP-1 NAP1	interleukin 8	diphenyleneiodonium inhibits the reaction [lactacystin results in increased expression of IL8 mRNA]	decreases reaction / increases expression	mRNA	12208513
C067713	3576	IL8 CXCL8 GCP-1 GCP1 LECT LUCT LYNAP MDNCF MONAP NAF NAP-1 NAP1	interleukin 8	Glutathione inhibits the reaction [lactacystin results in increased expression of IL8 mRNA]	decreases reaction / increases expression	mRNA	12208513
C067713	3576	IL8 CXCL8 GCP-1 GCP1 LECT LUCT LYNAP MDNCF MONAP NAF NAP-1 NAP1	interleukin 8	lactacystin results in increased expression of IL8 mRNA	increases expression	mRNA	12208513
C067713	3576	IL8 CXCL8 GCP-1 GCP1 LECT LUCT LYNAP MDNCF MONAP NAF NAP-1 NAP1	interleukin 8	Rotenone inhibits the reaction [lactacystin results in increased expression of IL8 mRNA]	decreases reaction / increases expression	mRNA	12208513
C067713	3684	ITGAM CD11B CR3A MAC-1 MAC1A MO1A SLEB6	integrin, alpha M (complement component 3 receptor 3 subunit)	lactacystin promotes the reaction [Tretinoin results in increased expression of ITGAM protein]	increases expression / increases reaction	protein	20945414
C067713	4780	NFE2L2 NRF2	nuclear factor, erythroid 2-like 2	lactacystin results in increased expression of NFE2L2 protein	increases expression	protein	12446695
C067713	4792	NFKBIA IKBA MAD-3 NFKBI	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	lactacystin promotes the reaction [Deoxycholic Acid results in increased phosphorylation of NFKBIA protein]	increases phosphorylation / increases reaction	protein	17644113
C067713	5009	OTC OCTD	ornithine carbamoyltransferase (EC:2.1.3.3)	lactacystin inhibits the reaction [Oxygen results in decreased metabolism of OTC protein]	decreases metabolic processing / decreases reaction	protein	11161710
C067713	5009	OTC OCTD	ornithine carbamoyltransferase (EC:2.1.3.3)	lactacystin results in decreased metabolism of OTC protein	decreases metabolic processing	protein	11161710
C067713	11315	PARK7 DJ-1 DJ1	parkinson protein 7	PARK7 protein results in decreased susceptibility to lactacystin	decreases response to substance	protein	18331584
C067713	64714	PDIA2 PDA2 PDI PDIP PDIR	protein disulfide isomerase family A, member 2 (EC:5.3.4.1)	lactacystin results in increased expression of PDIA2 mRNA	increases expression	mRNA	15353226
C067713	64714	PDIA2 PDA2 PDI PDIP PDIR	protein disulfide isomerase family A, member 2 (EC:5.3.4.1)	lactacystin results in increased expression of PDIA2 protein	increases expression	protein	15353226
C067713	23645	PPP1R15A GADD34	protein phosphatase 1, regulatory subunit 15A	lactacystin results in increased expression of PPP1R15A mRNA	increases expression	mRNA	19135031
C067713	5579	PRKCB PKC-beta PKCB PRKCB1 PRKCB2	protein kinase C, beta (EC:2.7.11.13)	lactacystin inhibits the reaction [Deoxycholic Acid results in increased expression of PRKCB protein]	decreases reaction / increases expression	protein	17644113
C067713	5710	PSMD4 AF AF-1 ASF MCB1 Rpn10 S5A pUB-R5	proteasome (prosome, macropain) 26S subunit, non-ATPase, 4	lactacystin promotes the reaction [VCP protein binds to UBXN1 protein binds to PSMD4 protein]	affects binding / increases reaction	protein	15362974
C067713	5970	RELA NFKB3 p65	v-rel avian reticuloendotheliosis viral oncogene homolog A	lactacystin inhibits the reaction [Deoxycholic Acid results in increased localization of RELA protein]	decreases reaction / increases localization	protein	17644113
C067713	5054	SERPINE1 PAI PAI-1 PAI1 PLANH1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	lactacystin inhibits the reaction [tin protoporphyrin IX inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 protein]]	decreases reaction / increases expression	protein	18344023
C067713	6502	SKP2 FBL1 FBXL1 FLB1 p45	S-phase kinase-associated protein 2, E3 ubiquitin protein ligase	lactacystin inhibits the reaction [Estradiol results in increased expression of SKP2 protein]	decreases reaction / increases expression	protein	23029392
C067713	6502	SKP2 FBL1 FBXL1 FLB1 p45	S-phase kinase-associated protein 2, E3 ubiquitin protein ligase	lactacystin results in decreased expression of SKP2 protein	decreases expression	protein	23029392
C067713	1317	SLC31A1 COPT1 CTR1	solute carrier family 31 (copper transporter), member 1	lactacystin inhibits the reaction [Cisplatin results in increased degradation of SLC31A1 protein]	decreases reaction / increases degradation	protein	17108132
C067713	6622	SNCA NACP PARK1 PARK4 PD1	synuclein, alpha (non A4 component of amyloid precursor)	lactacystin promotes the reaction [SNCA protein mutant form binds to SNCA protein mutant form]	affects binding / increases reaction	protein	16584840
C067713	6647	SOD1 ALS ALS1 IPOA SOD hSod1 homodimer	superoxide dismutase 1, soluble (EC:1.15.1.1)	lactacystin inhibits the reaction [Glucose deficiency results in increased degradation of SOD1 protein]	decreases reaction / increases degradation	protein	17309078
C067713	6794	STK11 LKB1 PJS hLKB1	serine/threonine kinase 11 (EC:2.7.11.1)	lactacystin inhibits the reaction [[Cisplatin results in increased phosphorylation of TP63 protein alternative form] which results in increased degradation of STK11 protein]	decreases reaction / increases degradation / increases phosphorylation	protein	21191146
C067713	7040	TGFB1 CED DPD1 LAP TGFB TGFbeta	transforming growth factor, beta 1	lactacystin inhibits the reaction [tin protoporphyrin IX inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 protein]]	decreases reaction / increases expression	protein	18344023
C067713	7124	TNF DIF TNF-alpha TNFA TNFSF2	tumor necrosis factor	lactacystin inhibits the reaction [TNF protein results in increased expression of COMT protein]	decreases reaction / increases expression	protein	17138778
C067713	9804	TOMM20 MAS20 MOM19 TOM20	translocase of outer mitochondrial membrane 20 homolog (yeast)	lactacystin affects the localization of TOMM20 protein	affects localization	protein	11161710
C067713	8626	TP63 AIS B(p51A) B(p51B) EEC3 KET LMS NBP OFC8 RHS SHFM4 TP53CP TP53L TP73L p40 p51 p53CP p63 p73H p73L	tumor protein p63	lactacystin inhibits the reaction [[Cisplatin results in increased phosphorylation of TP63 protein alternative form] which results in increased degradation of STK11 protein]	decreases reaction / increases degradation / increases phosphorylation	protein	21191146
C067713	8626	TP63 AIS B(p51A) B(p51B) EEC3 KET LMS NBP OFC8 RHS SHFM4 TP53CP TP53L TP73L p40 p51 p53CP p63 p73H p73L	tumor protein p63	lactacystin inhibits the reaction [[Cisplatin results in increased phosphorylation of TP63 protein alternative form] which results in increased degradation of TP63 protein alternative form]	decreases reaction / increases degradation / increases phosphorylation	protein	21191146
C067713	51035	UBXN1 2B28 SAKS1 UBXD10	UBX domain protein 1	lactacystin promotes the reaction [VCP protein binds to UBXN1 protein binds to PSMD4 protein]	affects binding / increases reaction	protein	15362974
C067713	7415	VCP ALS14 IBMPFD IBMPFD1 TERA p97	valosin containing protein (EC:3.6.4.6)	lactacystin promotes the reaction [VCP protein binds to UBXN1 protein binds to PSMD4 protein]	affects binding / increases reaction	protein	15362974
C067713	7415	VCP ALS14 IBMPFD IBMPFD1 TERA p97	valosin containing protein (EC:3.6.4.6)	lactacystin results in increased expression of VCP protein	increases expression	protein	15362974
C067713	7494	XBP1 TREB5 XBP-1 XBP2	X-box binding protein 1	XBP1 protein results in decreased susceptibility to lactacystin	decreases response to substance	protein	19135031

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (1)

OMIM	preferred title	UniProt
#256040	Autoinflammation, lipodystrophy, and dermatosis syndrome; aldd	P28062

Diseases related to CTD interactions

4 disease from interactions of metabolites

MeSH disease	compound	disease name	evidence type	reference pmid
D004195	C067713	Disease Models, Animal	marker/mechanism	19894114 20649845
D001523	C067713	Mental Disorders	marker/mechanism	19223692
D009069	C067713	Movement Disorders	marker/mechanism	20649845
D009461	C067713	Neurologic Manifestations	marker/mechanism	19894114 20649845

KNApSAcK Metabolite C00017067

Index Metabolite Species Human Protein / Gene in interactions Related Diseases

Metabolite

KNApSAcK Entry

Cluster

Link

ChEMBL

KEGG

CTD

Species

Summary

Plant class

Family

List (1)

* NCBI

Human Protein / Gene in interaction

3 ChEMBL Protein in interactions

CTD interaction (70)

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (1)

Diseases related to CTD interactions

4 disease from interactions of metabolites

Index

Metabolite

Species

Human Protein
/ Gene in interactions

Related Diseases