Streptomyces sp. OM-6519
Species
KNApSAcK Entry
| Organism name | Streptomyces sp. OM-6519 |
|---|---|
| Genus | Streptomyces |
| Family | Streptomycetaceae |
| Kingdom | Bacteria |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Streptomyces |
|---|---|
| Linked NCBI taxonomy ID | 1883 |
| Linked level | genus |
Family
| Family in NCBI taxonomy | Streptomycetaceae |
|---|---|
| ID | 2062 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Bacteria |
|---|---|
| ID | 2 |
Plant class
| Plant class | |
|---|---|
| ID |
Metabolite list (1)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00017067
|
Lactacystin
/ (+)-Lactacystin |
CHEMBL374308
|
C067713
|
3 / 1 / 0 | 46 / 4 | No. 6826 |
|
Human Protein / Gene in interactions
3 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P28062 | Proteasome subunit beta type-8 | T1A | C00017067 | 1 / 0 |
| Q15393 | Splicing factor 3B subunit 3 | Unclassified protein | C00017067 | 0 / 0 |
| P28074 | Proteasome subunit beta type-5 | T1A | C00017067 | 0 / 0 |
46 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 196 | AHR, bHLHe76 | aryl hydrocarbon receptor |
C00017067
|
| 338 | APOB, FLDB, LDLCQ4 | apolipoprotein B |
C00017067
|
| 351 | APP, AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN-II, PN2 | amyloid beta (A4) precursor protein |
C00017067
|
| 596 | BCL2, Bcl-2, PPP1R50 | B-cell CLL/lymphoma 2 |
C00017067
|
| 595 | CCND1, BCL1, D11S287E, PRAD1, U21B31 | cyclin D1 |
C00017067
|
| 898 | CCNE1, CCNE | cyclin E1 |
C00017067
|
| 1027 | CDKN1B, CDKN4, KIP1, MEN1B, MEN4, P27KIP1 | cyclin-dependent kinase inhibitor 1B (p27, Kip1) |
C00017067
|
| 1051 | CEBPB, C/EBP-beta, CRP2, IL6DBP, LAP, LIP, NF-IL6, TCF5 | CCAAT/enhancer binding protein (C/EBP), beta |
C00017067
|
| 1052 | CEBPD, C/EBP-delta, CELF, CRP3, NF-IL6-beta | CCAAT/enhancer binding protein (C/EBP), delta |
C00017067
|
| 1312 | COMT | catechol-O-methyltransferase (EC:2.1.1.6) |
C00017067
|
| 1499 | CTNNB1, CTNNB, MRD19, armadillo | catenin (cadherin-associated protein), beta 1, 88kDa |
C00017067
|
| 1649 | DDIT3, CEBPZ, CHOP, CHOP-10, CHOP10, GADD153 | DNA-damage-inducible transcript 3 |
C00017067
|
| 1734 | DIO2, 5DII, D2, DIOII, SelY, TXDI2 | deiodinase, iodothyronine, type II (EC:1.97.1.10) |
C00017067
|
| 1977 | EIF4E, AUTS19, CBP, EIF4E1, EIF4EL1, EIF4F | eukaryotic translation initiation factor 4E |
C00017067
|
| 51343 | FZR1, CDC20C, CDH1, FZR, FZR2, HCDH, HCDH1 | fizzy/cell division cycle 20 related 1 (Drosophila) |
C00017067
|
| 2744 | GLS, AAD20, GAC, GAM, GLS1, KGA | glutaminase (EC:3.5.1.2) |
C00017067
|
| 2939 | GSTA2, GST2, GSTA2-2, GTA2, GTH2 | glutathione S-transferase alpha 2 (EC:2.5.1.18) |
C00017067
|
| 3091 | HIF1A, HIF-1A, HIF-1alpha, HIF1, HIF1-ALPHA, MOP1, PASD8, bHLHe78 | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) |
C00017067
|
| 3297 | HSF1, HSTF1 | heat shock transcription factor 1 |
C00017067
|
| 3298 | HSF2, HSF_2, HSTF_2 | heat shock transcription factor 2 |
C00017067
|
| 3309 | HSPA5, BIP, GRP78, MIF2 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) |
C00017067
|
| 3569 | IL6, BSF2, HGF, HSF, IFNB2, IL-6 | interleukin 6 (interferon, beta 2) |
C00017067
|
| 3576 | IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 | interleukin 8 |
C00017067
|
| 3684 | ITGAM, CD11B, CR3A, MAC-1, MAC1A, MO1A, SLEB6 | integrin, alpha M (complement component 3 receptor 3 subunit) |
C00017067
|
| 4780 | NFE2L2, NRF2 | nuclear factor, erythroid 2-like 2 |
C00017067
|
| 4792 | NFKBIA, IKBA, MAD-3, NFKBI | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha |
C00017067
|
| 5009 | OTC, OCTD | ornithine carbamoyltransferase (EC:2.1.3.3) |
C00017067
|
| 11315 | PARK7, DJ-1, DJ1 | parkinson protein 7 |
C00017067
|
| 64714 | PDIA2, PDA2, PDI, PDIP, PDIR | protein disulfide isomerase family A, member 2 (EC:5.3.4.1) |
C00017067
|
| 23645 | PPP1R15A, GADD34 | protein phosphatase 1, regulatory subunit 15A |
C00017067
|
| 5579 | PRKCB, PKC-beta, PKCB, PRKCB1, PRKCB2 | protein kinase C, beta (EC:2.7.11.13) |
C00017067
|
| 5710 | PSMD4, AF, AF-1, ASF, MCB1, Rpn10, S5A, pUB-R5 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 |
C00017067
|
| 5970 | RELA, NFKB3, p65 | v-rel avian reticuloendotheliosis viral oncogene homolog A |
C00017067
|
| 5054 | SERPINE1, PAI, PAI-1, PAI1, PLANH1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 |
C00017067
|
| 6502 | SKP2, FBL1, FBXL1, FLB1, p45 | S-phase kinase-associated protein 2, E3 ubiquitin protein ligase |
C00017067
|
| 1317 | SLC31A1, COPT1, CTR1 | solute carrier family 31 (copper transporter), member 1 |
C00017067
|
| 6622 | SNCA, NACP, PARK1, PARK4, PD1 | synuclein, alpha (non A4 component of amyloid precursor) |
C00017067
|
| 6647 | SOD1, ALS, ALS1, IPOA, SOD, hSod1, homodimer | superoxide dismutase 1, soluble (EC:1.15.1.1) |
C00017067
|
| 6794 | STK11, LKB1, PJS, hLKB1 | serine/threonine kinase 11 (EC:2.7.11.1) |
C00017067
|
| 7040 | TGFB1, CED, DPD1, LAP, TGFB, TGFbeta | transforming growth factor, beta 1 |
C00017067
|
| 7124 | TNF, DIF, TNF-alpha, TNFA, TNFSF2 | tumor necrosis factor |
C00017067
|
| 9804 | TOMM20, MAS20, MOM19, TOM20 | translocase of outer mitochondrial membrane 20 homolog (yeast) |
C00017067
|
| 8626 | TP63, AIS, B(p51A), B(p51B), EEC3, KET, LMS, NBP, OFC8, RHS, SHFM4, TP53CP, TP53L, TP73L, p40, p51, p53CP, p63, p73H, p73L | tumor protein p63 |
C00017067
|
| 51035 | UBXN1, 2B28, SAKS1, UBXD10 | UBX domain protein 1 |
C00017067
|
| 7415 | VCP, ALS14, IBMPFD, IBMPFD1, TERA, p97 | valosin containing protein (EC:3.6.4.6) |
C00017067
|
| 7494 | XBP1, TREB5, XBP-1, XBP2 | X-box binding protein 1 |
C00017067
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (1)
| OMIM | preferred title | UniProt |
|---|---|---|
| #256040 | Autoinflammation, lipodystrophy, and dermatosis syndrome; aldd |
P28062
|