PCIDB

KNApSAcK Metabolite C00001710

Metabolite

KNApSAcK Entry

id C00001710
Name Cryptolepine
CAS RN 480-26-2
Standard InChI InChI=1S/C16H12N2/c1-18-15-9-5-2-6-11(15)10-14-16(18)12-7-3-4-8-13(12)17-14/h2-10H,1H3
Standard InChI (Main Layer) InChI=1S/C16H12N2/c1-18-15-9-5-2-6-11(15)10-14-16(18)12-7-3-4-8-13(12)17-14/h2-10H,1H3

Cluster

Phytochemical cluster
KCF-S cluster No. 2144

Link

ChEMBL

By standard InChI CHEMBL119096
By standard InChI Main Layer CHEMBL119096 CHEMBL456244

KEGG

By LinkDB C09142

CTD

By CAS RN C024015

Species

Summary

Plant class

class name count
asterids 2

Family

family name count
Apocynaceae 2

List (2)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Cryptolepis sanguinolenta 165212 Apocynaceae asterids Viridiplantae
Cryptolepis triangularis 165212 Apocynaceae asterids Viridiplantae

Human Protein / Gene in interaction

CTD interaction (30)

compound gene gene name gene description interaction interaction type form reference
pmid
C024015 581 BAX
BCL2L4
BCL2-associated X protein cryptolepine results in increased expression of BAX mRNA increases expression
mRNA 16120219
C024015 581 BAX
BCL2L4
BCL2-associated X protein cryptolepine results in increased expression of BAX protein increases expression
protein 16120219
C024015 330 BIRC3
AIP1
API2
CIAP2
HAIP1
HIAP1
MALT2
MIHC
RNF49
c-IAP2
baculoviral IAP repeat containing 3 cryptolepine results in decreased expression of BIRC3 mRNA decreases expression
mRNA 16120219
C024015 699 BUB1
BUB1A
BUB1L
hBUB1
BUB1 mitotic checkpoint serine/threonine kinase (EC:2.7.11.1) cryptolepine results in decreased expression of BUB1 mRNA decreases expression
mRNA 16120219
C024015 701 BUB1B
BUB1beta
BUBR1
Bub1A
MAD3L
MVA1
SSK1
hBUBR1
BUB1 mitotic checkpoint serine/threonine kinase B (EC:2.7.11.1) cryptolepine results in decreased expression of BUB1B mRNA decreases expression
mRNA 16120219
C024015 890 CCNA2
CCN1
CCNA
cyclin A2 cryptolepine results in decreased expression of CCNA2 mRNA decreases expression
mRNA 16120219
C024015 890 CCNA2
CCN1
CCNA
cyclin A2 cryptolepine results in decreased expression of CCNA2 protein decreases expression
protein 16120219
C024015 891 CCNB1
CCNB
cyclin B1 cryptolepine results in decreased expression of CCNB1 mRNA decreases expression
mRNA 16120219
C024015 891 CCNB1
CCNB
cyclin B1 cryptolepine results in decreased expression of CCNB1 protein decreases expression
protein 16120219
C024015 595 CCND1
BCL1
D11S287E
PRAD1
U21B31
cyclin D1 cryptolepine results in increased expression of CCND1 mRNA increases expression
mRNA 16120219
C024015 995 CDC25C
CDC25
PPP1R60
cell division cycle 25C (EC:3.1.3.48) cryptolepine results in decreased expression of CDC25C mRNA decreases expression
mRNA 16120219
C024015 997 CDC34
E2-CDC34
UBC3
UBCH3
UBE2R1
cell division cycle 34 (EC:6.3.2.19) cryptolepine results in decreased expression of CDC34 mRNA decreases expression
mRNA 16120219
C024015 31052 cryptolepine results in decreased expression of CDC45L mRNA decreases expression
mRNA 16120219
C024015 990 CDC6
CDC18L
HsCDC18
HsCDC6
cell division cycle 6 cryptolepine results in decreased expression of CDC6 mRNA decreases expression
mRNA 16120219
C024015 1026 CDKN1A
CAP20
CDKN1
CIP1
MDA-6
P21
SDI1
WAF1
p21CIP1
cyclin-dependent kinase inhibitor 1A (p21, Cip1) cryptolepine results in increased expression of CDKN1A mRNA increases expression
mRNA 16120219
C024015 1026 CDKN1A
CAP20
CDKN1
CIP1
MDA-6
P21
SDI1
WAF1
p21CIP1
cyclin-dependent kinase inhibitor 1A (p21, Cip1) cryptolepine results in increased expression of CDKN1A protein increases expression
protein 16120219
C024015 1033 CDKN3
CDI1
CIP2
KAP
KAP1
cyclin-dependent kinase inhibitor 3 (EC:3.1.3.16 3.1.3.48) cryptolepine results in decreased expression of CDKN3 mRNA decreases expression
mRNA 16120219
C024015 1063 CENPF
CENF
PRO1779
hcp-1
centromere protein F, 350/400kDa cryptolepine results in decreased expression of CENPF mRNA decreases expression
mRNA 16120219
C024015 9518 GDF15
GDF-15
MIC-1
MIC1
NAG-1
PDF
PLAB
PTGFB
growth differentiation factor 15 cryptolepine results in increased expression of GDF15 mRNA increases expression
mRNA 16120219
C024015 4171 MCM2
BM28
CCNL1
CDCL1
D3S3194
MITOTIN
cdc19
minichromosome maintenance complex component 2 (EC:3.6.4.12) cryptolepine results in decreased expression of MCM2 mRNA decreases expression
mRNA 16120219
C024015 4175 MCM6
MCG40308
Mis5
P105MCM
minichromosome maintenance complex component 6 (EC:3.6.4.12) cryptolepine results in decreased expression of MCM6 mRNA decreases expression
mRNA 16120219
C024015 4176 MCM7
CDC47
MCM2
P1.1-MCM3
P1CDC47
P85MCM
PNAS146
minichromosome maintenance complex component 7 (EC:3.6.4.12) cryptolepine results in decreased expression of MCM7 mRNA decreases expression
mRNA 16120219
C024015 84515 MCM8
C20orf154
dJ967N21.5
minichromosome maintenance complex component 8 (EC:3.6.4.12) cryptolepine results in decreased expression of MCM8 mRNA decreases expression
mRNA 16120219
C024015 4193 MDM2
ACTFS
HDMX
hdm2
MDM2 oncogene, E3 ubiquitin protein ligase cryptolepine results in increased expression of MDM2 mRNA increases expression
mRNA 16120219
C024015 4193 MDM2
ACTFS
HDMX
hdm2
MDM2 oncogene, E3 ubiquitin protein ligase cryptolepine results in increased expression of MDM2 protein increases expression
protein 16120219
C024015 4661 MYT1
C20orf36
MTF1
MYTI
PLPB1
ZC2HC4A
myelin transcription factor 1 cryptolepine results in decreased expression of MYT1 mRNA decreases expression
mRNA 16120219
C024015 4751 NEK2
HsPK21
NEK2A
NLK1
NIMA-related kinase 2 (EC:2.7.11.1) cryptolepine results in decreased expression of NEK2 mRNA decreases expression
mRNA 16120219
C024015 7157 TP53
BCC7
LFS1
P53
TRP53
tumor protein p53 cryptolepine results in increased activity of TP53 protein increases activity
protein 16120219
C024015 7157 TP53
BCC7
LFS1
P53
TRP53
tumor protein p53 cryptolepine results in increased expression of TP53 protein increases expression
protein 16120219
C024015 7272 TTK
CT96
ESK
MPH1
MPS1
MPS1L1
PYT
TTK protein kinase (EC:2.7.12.1) cryptolepine results in decreased expression of TTK mRNA decreases expression
mRNA 16120219