PCIDB

KNApSAcK Metabolite C00017127

Metabolite

KNApSAcK Entry

id C00017127
Name Unidox / GS 3065 / Doxycen / Monodox / Ronaxan / Doxinyl / Liviatin / Pulmodox / Tolexine / Doxivetin / Dentistar / Hydramycin / Vibramycin / Medeomycin / Vibravenos / Vibramycine / Doxycycline / Deoxymykoin / Vibranos SF / Vibraveineuse / Doxytetracycline / alpha-Doxycycline / 6-Deoxyoxytetracycline / alpha-6-Deoxyoxytetracycline
CAS RN 564-25-0
Standard InChI InChI=1S/C22H24N2O8/c1-7-8-5-4-6-9(25)11(8)16(26)12-10(7)17(27)14-15(24(2)3)18(28)13(21(23)31)20(30)22(14,32)19(12)29/h4-7,10,14-15,17,25,27-29,32H,1-3H3,(H2,23,31)/t7-,10+,14+,15-,17-,22-/m0/s1
Standard InChI (Main Layer) InChI=1S/C22H24N2O8/c1-7-8-5-4-6-9(25)11(8)16(26)12-10(7)17(27)14-15(24(2)3)18(28)13(21(23)31)20(30)22(14,32)19(12)29/h4-7,10,14-15,17,25,27-29,32H,1-3H3,(H2,23,31)

Cluster

Phytochemical cluster
KCF-S cluster No. 5500

Link

ChEMBL

By standard InChI CHEMBL1433
By standard InChI Main Layer CHEMBL1433 CHEMBL1372176 CHEMBL1616405 CHEMBL1624566

KEGG

By LinkDB C06973

CTD

By CAS RN D004318

Species

Summary

Plant class

class name count

Family

family name count
Streptomycetaceae 1

List (1)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Streptomyces violaceus P950-4 (ATCC 53807) 1883 Streptomycetaceae Bacteria

Human Protein / Gene in interaction

114 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 CHEMBL1433 CHEMBL1372176 CHEMBL1741321 (2) CHEMBL1909136 (2)
1 / 0
P49798 Regulator of G-protein signaling 4 Unclassified protein CHEMBL1433 CHEMBL1794499 (1)
2 / 0
P21728 D(1A) dopamine receptor Dopamine receptor CHEMBL1433 CHEMBL1738091 (1) CHEMBL1909139 (2)
0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase CHEMBL1433 CHEMBL1909131 (2)
0 / 3
Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH, Kv10-12.x (Ether-a-go-go) CHEMBL1433 CHEMBL1909190 (2)
2 / 2
P08246 Neutrophil elastase S1A CHEMBL1433 CHEMBL1909195 (2)
2 / 1
P33765 Adenosine receptor A3 Adenosine receptor CHEMBL1433 CHEMBL1909215 (2)
0 / 0
Q16539 Mitogen-activated protein kinase 14 p38 CHEMBL1433 CHEMBL1909201 (2)
0 / 0
P49146 Neuropeptide Y receptor type 2 Neuropeptide Y receptor CHEMBL1433 CHEMBL1909176 (2)
0 / 0
P22894 Neutrophil collagenase M10A CHEMBL1433 CHEMBL891124 (1)
0 / 0
P29466 Caspase-1 C14 CHEMBL1433 CHEMBL1909193 (2)
0 / 0
P17252 Protein kinase C alpha type Alpha CHEMBL1433 CHEMBL1909198 (2)
0 / 0
P27361 Mitogen-activated protein kinase 3 Erk CHEMBL1433 CHEMBL1909199 (2)
0 / 0
P14780 Matrix metalloproteinase-9 M10A CHEMBL1433 CHEMBL1059542 (1) CHEMBL1909197 (2)
2 / 2
O15245 Solute carrier family 22 member 1 Drug uniporter CHEMBL1433 CHEMBL993349 (1)
0 / 0
O75604 Ubiquitin carboxyl-terminal hydrolase 2 Enzyme CHEMBL1372176 CHEMBL1614331 (2)
0 / 0
P16473 Thyrotropin receptor Glycohormone receptor CHEMBL1372176 CHEMBL1614361 (1)
3 / 2
P00918 Carbonic anhydrase 2 Lyase CHEMBL1433 CHEMBL1909123 (2)
1 / 2
P07550 Beta-2 adrenergic receptor Adrenergic receptor CHEMBL1433 CHEMBL1909092 (2)
0 / 1
P21397 Amine oxidase [flavin-containing] A Oxidoreductase CHEMBL1433 CHEMBL1909169 (2)
1 / 1
P25021 Histamine H2 receptor Histamine receptor CHEMBL1433 CHEMBL1909157 (2)
0 / 0
P35367 Histamine H1 receptor Histamine receptor CHEMBL1433 CHEMBL1909156 (2)
0 / 0
Q01959 Sodium-dependent dopamine transporter Dopamine CHEMBL1433 CHEMBL1909143 (2)
1 / 0
P08912 Muscarinic acetylcholine receptor M5 Acetylcholine receptor CHEMBL1433 CHEMBL1909174 (2)
0 / 0
P18825 Alpha-2C adrenergic receptor Adrenergic receptor CHEMBL1433 CHEMBL1909090 (2)
0 / 0
P13945 Beta-3 adrenergic receptor Adrenergic receptor CHEMBL1433 CHEMBL1909093 (2)
0 / 0
P02768 Serum albumin Secreted protein CHEMBL1433 CHEMBL702885 (1)
0 / 0
P25024 C-X-C chemokine receptor type 1 CXC chemokine receptor CHEMBL1433 CHEMBL1909127 (2)
0 / 0
P06241 Tyrosine-protein kinase Fyn Src CHEMBL1433 CHEMBL1909204 (2)
0 / 0
Q08209 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform Ser_Thr CHEMBL1433 CHEMBL1909202 (2)
0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 CHEMBL1433 CHEMBL1372176 CHEMBL1741325 (2) CHEMBL1909135 (2)
0 / 1
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily CHEMBL1433 CHEMBL1909203 (2)
1 / 11
P11473 Vitamin D3 receptor NR1I1 CHEMBL1433 CHEMBL1372176 CHEMBL1794311 (2)
2 / 3
P14416 D(2) dopamine receptor Dopamine receptor CHEMBL1433 CHEMBL1909140 (2)
2 / 0
P23219 Prostaglandin G/H synthase 1 Oxidoreductase CHEMBL1433 CHEMBL1909130 (2)
0 / 0
P37288 Vasopressin V1a receptor Vasopressin and oxytocin receptor CHEMBL1433 CHEMBL1909120 (2)
0 / 0
P41145 Kappa-type opioid receptor Opioid receptor CHEMBL1433 CHEMBL1909181 (2)
0 / 0
Q9Y271 Cysteinyl leukotriene receptor 1 Leukotriene receptor CHEMBL1433 CHEMBL1909164 (2)
0 / 0
P29274 Adenosine receptor A2a Adenosine receptor CHEMBL1433 CHEMBL1909214 (2)
0 / 0
P25929 Neuropeptide Y receptor type 1 Neuropeptide Y receptor CHEMBL1433 CHEMBL1909175 (2)
0 / 0
P50052 Type-2 angiotensin II receptor Angiotensin receptor CHEMBL1433 CHEMBL1909096 (2)
1 / 1
P17948 Vascular endothelial growth factor receptor 1 Vegfr CHEMBL1433 CHEMBL1909118 (2)
0 / 0
P41968 Melanocortin receptor 3 Melanocortin receptor CHEMBL1433 CHEMBL1909166 (2)
1 / 0
P11509 Cytochrome P450 2A6 Cytochrome P450 2A6 CHEMBL1433 CHEMBL1909133 (2)
0 / 0
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor CHEMBL1372176 CHEMBL1614456 (2) CHEMBL1613803 (2)
0 / 0
P39748 Flap endonuclease 1 Enzyme CHEMBL1433 CHEMBL1613922 (1) CHEMBL1794486 (1)
0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme CHEMBL1433 CHEMBL1738606 (1)
0 / 0
Q8TCC7 Solute carrier family 22 member 8 Antiporter CHEMBL1433 CHEMBL2075885 (1)
0 / 0
P04035 3-hydroxy-3-methylglutaryl-coenzyme A reductase Oxidoreductase CHEMBL1433 CHEMBL1909158 (2)
0 / 0
P08913 Alpha-2A adrenergic receptor Adrenergic receptor CHEMBL1433 CHEMBL1909088 (2)
0 / 0
P21917 D(4) dopamine receptor Dopamine receptor CHEMBL1433 CHEMBL1909142 (2)
0 / 0
P30988 Calcitonin receptor Calcitonin receptor CHEMBL1433 CHEMBL1909101 (2)
0 / 0
P35462 D(3) dopamine receptor Dopamine receptor CHEMBL1433 CHEMBL1909141 (2)
1 / 0
P41143 Delta-type opioid receptor Opioid receptor CHEMBL1433 CHEMBL1909180 (2)
0 / 0
Q92731 Estrogen receptor beta NR3A2 CHEMBL1433 CHEMBL1909146 (2)
0 / 1
P41595 5-hydroxytryptamine receptor 2B Serotonin receptor CHEMBL1433 CHEMBL1909104 (2)
0 / 0
P25101 Endothelin-1 receptor Endothelin receptor CHEMBL1433 CHEMBL1909144 (2)
0 / 0
P30411 B2 bradykinin receptor Bradykinin receptor CHEMBL1433 CHEMBL1909100 (2)
0 / 0
P32245 Melanocortin receptor 4 Melanocortin receptor CHEMBL1433 CHEMBL1909167 (2)
1 / 0
P32238 Cholecystokinin receptor type A Cholecystokinin receptor CHEMBL1433 CHEMBL1909129 (2)
0 / 0
P08311 Cathepsin G S1A CHEMBL1433 CHEMBL1909194 (2)
0 / 0
Q99720 Sigma non-opioid intracellular receptor 1 Membrane receptor CHEMBL1433 CHEMBL1909110 (2)
1 / 0
P03956 Interstitial collagenase M10A CHEMBL1433 CHEMBL1909196 (2)
0 / 1
P32241 Vasoactive intestinal polypeptide receptor 1 Vasoactive intestinal peptide receptor CHEMBL1433 CHEMBL1909119 (2)
0 / 0
P55085 Proteinase-activated receptor 2 Protease-activated receptor CHEMBL1433 CHEMBL1661209 (1) CHEMBL1661210 (1)
CHEMBL1661211 (1) CHEMBL1661212 (1)
CHEMBL1661213 (1)
0 / 0
Q4U2R8 Solute carrier family 22 member 6 Antiporter CHEMBL1433 CHEMBL2077182 (1)
0 / 0
P83916 Chromobox protein homolog 1 Unclassified protein CHEMBL1433 CHEMBL1738610 (1)
0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme CHEMBL1372176 CHEMBL1794467 (1)
0 / 0
P04150 Glucocorticoid receptor NR3C1 CHEMBL1433 CHEMBL1909150 (2)
0 / 1
P08172 Muscarinic acetylcholine receptor M2 Acetylcholine receptor CHEMBL1433 CHEMBL1909171 (2)
2 / 0
P11229 Muscarinic acetylcholine receptor M1 Acetylcholine receptor CHEMBL1433 CHEMBL1909170 (2)
0 / 0
P21554 Cannabinoid receptor 1 Cannabinoid receptor CHEMBL1433 CHEMBL1909122 (2)
0 / 0
P31645 Sodium-dependent serotonin transporter Serotonin CHEMBL1433 CHEMBL1909109 (2)
2 / 0
P04626 Receptor tyrosine-protein kinase erbB-2 TK tyrosine-protein kinase EGFR subfamily CHEMBL1433 CHEMBL1909205 (2)
5 / 10
P20309 Muscarinic acetylcholine receptor M3 Acetylcholine receptor CHEMBL1433 CHEMBL1909172 (2)
1 / 0
P21452 Substance-K receptor Neurokinin receptor CHEMBL1433 CHEMBL1909114 (2)
0 / 0
P51679 C-C chemokine receptor type 4 CC chemokine receptor CHEMBL1433 CHEMBL1909125 (2)
0 / 0
P51681 C-C chemokine receptor type 5 CC chemokine receptor CHEMBL1433 CHEMBL1909126 (2)
3 / 0
P50406 5-hydroxytryptamine receptor 6 Serotonin receptor CHEMBL1433 CHEMBL1909108 (2)
0 / 0
P45452 Collagenase 3 M10A CHEMBL1433 CHEMBL891125 (1)
1 / 1
P41597 C-C chemokine receptor type 2 CC chemokine receptor CHEMBL1433 CHEMBL1909124 (2)
1 / 0
P28482 Mitogen-activated protein kinase 1 Erk CHEMBL1433 CHEMBL1909200 (2)
0 / 0
P08575 Receptor-type tyrosine-protein phosphatase C Enzyme CHEMBL1433 CHEMBL1909207 (2)
2 / 1
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 CHEMBL1433 CHEMBL1372176 CHEMBL1741322 (2) CHEMBL1909132 (2)
0 / 0
P08253 72 kDa type IV collagenase M10A CHEMBL1433 CHEMBL891122 (1) CHEMBL1059541 (1)
1 / 3
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme CHEMBL1372176 CHEMBL1613910 (1) CHEMBL1614227 (1)
3 / 3
O76074 cGMP-specific 3',5'-cyclic phosphodiesterase PDE_5A CHEMBL1433 CHEMBL1909186 (2)
0 / 0
P03372 Estrogen receptor NR3A1 CHEMBL1433 CHEMBL1909145 (2)
1 / 1
P08588 Beta-1 adrenergic receptor Adrenergic receptor CHEMBL1433 CHEMBL1909091 (2)
1 / 0
P22303 Acetylcholinesterase Hydrolase CHEMBL1433 CHEMBL1909212 (2)
1 / 0
P28223 5-hydroxytryptamine receptor 2A Serotonin receptor CHEMBL1433 CHEMBL1909211 (2)
0 / 0
P28335 5-hydroxytryptamine receptor 2C Serotonin receptor CHEMBL1433 CHEMBL1909105 (2)
0 / 0
P35372 Mu-type opioid receptor Opioid receptor CHEMBL1433 CHEMBL1909182 (2)
0 / 0
P08173 Muscarinic acetylcholine receptor M4 Acetylcholine receptor CHEMBL1433 CHEMBL1909173 (2)
0 / 0
P25103 Substance-P receptor Neurokinin receptor CHEMBL1433 CHEMBL1909113 (2)
0 / 0
P25105 Platelet-activating factor receptor PAF receptor CHEMBL1433 CHEMBL1909187 (2)
0 / 0
P33032 Melanocortin receptor 5 Melanocortin receptor CHEMBL1433 CHEMBL1909168 (2)
0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 CHEMBL1433 CHEMBL1372176 CHEMBL1741323 (2) CHEMBL1909134 (2)
1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 CHEMBL1433 CHEMBL1372176 CHEMBL1741324 (2) CHEMBL1909138 (2)
0 / 1
P05181 Cytochrome P450 2E1 Cytochrome P450 2E1 CHEMBL1433 CHEMBL1909137 (2)
0 / 0
Q9UM07 Protein-arginine deiminase type-4 Enzyme CHEMBL1433 CHEMBL929914 (1) CHEMBL929916 (1)
1 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein CHEMBL1433 CHEMBL1737980 (1)
0 / 0
P23975 Sodium-dependent noradrenaline transporter Norepinephrine CHEMBL1433 CHEMBL1909094 (2)
1 / 1
P25100 Alpha-1D adrenergic receptor Adrenergic receptor CHEMBL1433 CHEMBL1909087 (2)
0 / 0
P30542 Adenosine receptor A1 Adenosine receptor CHEMBL1433 CHEMBL1909213 (2)
0 / 0
P18089 Alpha-2B adrenergic receptor Adrenergic receptor CHEMBL1433 CHEMBL1909089 (2)
0 / 0
P24557 Thromboxane-A synthase Cytochrome P450 5A1 CHEMBL1433 CHEMBL1909116 (2)
1 / 1
P06239 Tyrosine-protein kinase Lck Src CHEMBL1433 CHEMBL1909206 (2)
0 / 1
P25025 C-X-C chemokine receptor type 2 CXC chemokine receptor CHEMBL1433 CHEMBL1909128 (2)
0 / 0
P08254 Stromelysin-1 M10A CHEMBL1433 CHEMBL891123 (1)
1 / 0
Q9UBT6 DNA polymerase kappa Enzyme CHEMBL1433 CHEMBL1794536 (1)
0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme CHEMBL1433 CHEMBL1738442 (2)
0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme CHEMBL1372176 CHEMBL1614364 (1)
1 / 1
Q9NSA0 Solute carrier family 22 member 11 Transporter CHEMBL1433 CHEMBL2075526 (1)
0 / 0

CTD interaction (28)

compound gene gene name gene description interaction interaction type form reference
pmid
D004318 5243 ABCB1
ABC20
CD243
CLCS
GP170
MDR1
P-GP
PGY1
ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) Doxycycline results in decreased expression of ABCB1 protein decreases expression
protein 11147995
D004318 196 AHR
bHLHe76
aryl hydrocarbon receptor Doxycycline results in increased expression of AHR protein increases expression
protein 22273977
D004318 196 AHR
bHLHe76
aryl hydrocarbon receptor [[Doxycycline results in increased expression of AHR protein] which co-treated with Tobacco Smoke Pollution] results in increased expression of CYP1B1 mRNA affects cotreatment
/ increases expression
protein 22273977
D004318 196 AHR
bHLHe76
aryl hydrocarbon receptor [Doxycycline results in increased expression of AHR protein] which results in increased expression of CYP1B1 mRNA increases expression
protein 22273977
D004318 1545 CYP1B1
CP1B
CYPIB1
GLC3A
P4501B1
cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) [[Doxycycline results in increased expression of AHR protein] which co-treated with Tobacco Smoke Pollution] results in increased expression of CYP1B1 mRNA affects cotreatment
/ increases expression
mRNA 22273977
D004318 1545 CYP1B1
CP1B
CYPIB1
GLC3A
P4501B1
cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) [Doxycycline results in increased expression of AHR protein] which results in increased expression of CYP1B1 mRNA increases expression
mRNA 22273977
D004318 3553 IL1B
IL-1
IL1-BETA
IL1F2
interleukin 1, beta Doxycycline analog inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA] decreases reaction
/ increases expression
protein 17267227
D004318 3553 IL1B
IL-1
IL1-BETA
IL1F2
interleukin 1, beta Doxycycline inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA] decreases reaction
/ increases expression
protein 17267227
D004318 3553 IL1B
IL-1
IL1-BETA
IL1F2
interleukin 1, beta Doxycycline inhibits the reaction [IL1B protein results in increased expression of MMP3 mRNA] decreases reaction
/ increases expression
protein 17267227
D004318 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 Doxycycline inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased secretion of IL8 protein] affects cotreatment
/ decreases reaction
/ increases secretion
protein 16134060
D004318 4322 MMP13
CLG3
MANDP1
matrix metallopeptidase 13 (collagenase 3) (EC:3.4.24.-) Doxycycline analog inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA] decreases reaction
/ increases expression
mRNA 17267227
D004318 4322 MMP13
CLG3
MANDP1
matrix metallopeptidase 13 (collagenase 3) (EC:3.4.24.-) Doxycycline analog results in decreased activity of MMP13 protein decreases activity
protein 17267227
D004318 4322 MMP13
CLG3
MANDP1
matrix metallopeptidase 13 (collagenase 3) (EC:3.4.24.-) Doxycycline inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA] decreases reaction
/ increases expression
mRNA 17267227
D004318 4322 MMP13
CLG3
MANDP1
matrix metallopeptidase 13 (collagenase 3) (EC:3.4.24.-) Doxycycline results in increased expression of MMP13 mRNA increases expression
mRNA 20338993
D004318 4313 MMP2
CLG4
CLG4A
MMP-II
MONA
TBE-1
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24) Doxycycline analog results in decreased activity of MMP2 protein decreases activity
protein 17267227
D004318 4313 MMP2
CLG4
CLG4A
MMP-II
MONA
TBE-1
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24) Doxycycline inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of and results in increased activity of MMP2 protein] decreases reaction
/ increases activity
/ increases expression
protein 19375915
D004318 4313 MMP2
CLG4
CLG4A
MMP-II
MONA
TBE-1
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24) Doxycycline inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP2 protein] decreases reaction
/ increases expression
protein 17498959
D004318 4314 MMP3
CHDS6
MMP-3
SL-1
STMY
STMY1
STR1
matrix metallopeptidase 3 (stromelysin 1, progelatinase) (EC:3.4.24.17) Doxycycline inhibits the reaction [IL1B protein results in increased expression of MMP3 mRNA] decreases reaction
/ increases expression
mRNA 17267227
D004318 4314 MMP3
CHDS6
MMP-3
SL-1
STMY
STMY1
STR1
matrix metallopeptidase 3 (stromelysin 1, progelatinase) (EC:3.4.24.17) Doxycycline results in decreased activity of MMP3 protein decreases activity
protein 17267227
D004318 4317 MMP8
CLG1
HNC
MMP-8
PMNL-CL
matrix metallopeptidase 8 (neutrophil collagenase) (EC:3.4.24.34) Doxycycline analog results in decreased activity of MMP8 protein decreases activity
protein 17267227
D004318 4318 MMP9
CLG4B
GELB
MANDP2
MMP-9
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) Doxycycline inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of and results in increased activity of MMP9 protein] decreases reaction
/ increases activity
/ increases expression
protein 19375915
D004318 4318 MMP9
CLG4B
GELB
MANDP2
MMP-9
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) Doxycycline inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 protein] decreases reaction
/ increases expression
protein 17498959
D004318 9356 SLC22A6
HOAT1
OAT1
PAHT
ROAT1
solute carrier family 22 (organic anion transporter), member 6 Doxycycline inhibits the reaction [SLC22A6 protein results in increased uptake of Anions] decreases reaction
/ increases uptake
protein 11855680
D004318 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Doxycycline inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased secretion of TNF protein] affects cotreatment
/ decreases reaction
/ increases secretion
protein 16134060
D004318 54575 UGT1A10
UDPGT
UGT-1J
UGT1-10
UGT1.10
UGT1J
UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17) Doxycycline promotes the reaction [Tobacco Smoke Pollution results in increased expression of UGT1A10 mRNA] increases expression
/ increases reaction
mRNA 22273977
D004318 54575 UGT1A10
UDPGT
UGT-1J
UGT1-10
UGT1.10
UGT1J
UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17) Doxycycline results in increased expression of UGT1A10 mRNA increases expression
mRNA 22273977
D004318 54576 UGT1A8
UDPGT
UDPGT_1-8
UGT-1H
UGT1-08
UGT1.8
UGT1A8S
UGT1H
UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17) Doxycycline promotes the reaction [Tobacco Smoke Pollution results in increased expression of UGT1A8 mRNA] increases expression
/ increases reaction
mRNA 22273977
D004318 54576 UGT1A8
UDPGT
UDPGT_1-8
UGT-1H
UGT1-08
UGT1.8
UGT1A8S
UGT1H
UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17) Doxycycline results in increased expression of UGT1A8 mRNA increases expression
mRNA 22273977

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (51)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#100100 Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism P20309
#103780 Alcohol dependence P08172
P14416
P31645
#614373 Amyotrophic lateral sclerosis 16, juvenile; als16 Q99720
#602025 Body mass index quantitative trait locus 9; bmiq9 P41968
#300615 Brunner syndrome P21397
#614466 Coronary heart disease, susceptibility to, 6; chds6 P08254
#162800 Cyclic neutropenia P08246
#612522 Diabetes mellitus, insulin-dependent, 22; iddm22 P51681
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#615363 Estrogen resistance; estrr P03372
#613659 Gastric cancer P04626
#137215 Gastric cancer, hereditary diffuse; hdgc P04626
#231095 Ghosal hematodiaphyseal dysplasia; ghdd P24557
#137800 Glioma susceptibility 1; glm1 P04626
#609423 Human immunodeficiency virus type 1, susceptibility to P41597
P51681
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#603932 Intervertebral disc disease; idd P14780
#613688 Long qt syndrome 2; lqt2 Q12809
#211980 Lung cancer P00533
P04626
#608516 Major depressive disorder; mdd P08172
#300705 Mental retardation, x-linked 17; mrx17 Q99714
%300852 Mental retardation, x-linked 88; mrx88 P50052
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#259600 Multicentric osteolysis, nodulosis, and arthropathy; mona P08253
#126200 Multiple sclerosis, susceptibility to; ms P08575
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#159900 Myoclonic dystonia P14416
#202700 Neutropenia, severe congenital, 1, autosomal dominant; scn1 P08246
#601665 Obesity P32245
#164230 Obsessive-compulsive disorder; ocd P31645
#604715 Orthostatic intolerance P23975
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#167000 Ovarian cancer P04626
#613135 Parkinsonism-dystonia, infantile; pkdys Q01959
#607276 Resting heart rate, variation in P08588
#180300 Rheumatoid arthritis; ra Q9UM07
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#608971 Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive P08575
#609620 Short qt syndrome 1; sqt1 Q12809
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#602111 Spondyloepimetaphyseal dysplasia, missouri type P45452
#190300 Tremor, hereditary essential, 1; etm1 P35462
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473
#610379 West nile virus, susceptibility to P51681
#112100 Yt blood group antigen P22303

KEGG DISEASE (40)

KEGG disease name UniProt
H00016 Oral cancer P00533 (related)
P00533 (marker)
H00017 Esophageal cancer P00533 (related)
P35354 (related)
H00018 Gastric cancer P00533 (related)
P04626 (related)
H00022 Bladder cancer P00533 (related)
P04626 (related)
H00028 Choriocarcinoma P00533 (related)
P03956 (related)
P04626 (related)
P08253 (related)
H00030 Cervical cancer P00533 (related)
P04626 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00026 Endometrial Cancer P03372 (marker)
P04626 (related)
Q92731 (marker)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00019 Pancreatic cancer P04626 (related)
H00027 Ovarian cancer P04626 (related)
H00031 Breast cancer P04626 (related)
P04626 (marker)
H00046 Cholangiocarcinoma P04626 (related)
P35354 (related)
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
H00079 Asthma P07550 (related)
H00100 Neutropenic disorders P08246 (related)
H00025 Penile cancer P08253 (related)
P14780 (related)
P35354 (related)
H00472 Torg-Winchester syndrome P08253 (related)
H00091 T-B+Severe combined immunodeficiencies (SCIDs) P08575 (related)
H00036 Osteosarcoma P08684 (marker)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H01205 Coumarin resistance P11712 (related)
H00479 Metaphyseal dysplasias P14780 (related)
P45452 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00548 Brunner syndrome P21397 (related)
H01031 Orthostatic intolerance (OI) P23975 (related)
H00490 Diaphyseal dysplasia with anemia (Ghosal) P24557 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00480 Non-syndromic X-linked mental retardation P50052 (related)
Q99714 (related)
H00720 Long QT syndrome Q12809 (related)
H00725 Short QT syndrome Q12809 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H00063 Spinocerebellar ataxia (SCA) Q9NUW8 (related)

Diseases related to CTD interactions

102 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D015746 D004318 Abdominal Pain marker/mechanism
10879639
13130401
D017486 D004318 Acneiform Eruptions therapeutic
21738965
D000152 D004318 Acne Vulgaris therapeutic
12900822
15891249
17404879
19204639
D000647 D004318 Amnesia marker/mechanism
17103211
D000783 D004318 Aneurysm therapeutic
15741211
D001008 D004318 Anxiety Disorders marker/mechanism
13130401
D001019 D004318 Aortic Rupture therapeutic
18178469
D001072 D004318 Apraxias marker/mechanism
9004058
D001416 D004318 Back Pain marker/mechanism
13130401
D001660 D004318 Biliary Tract Diseases therapeutic
138789
D001943 D004318 Breast Neoplasms marker/mechanism
19903844
D001991 D004318 Bronchitis therapeutic
9004058
D029481 D004318 Bronchitis, Chronic marker/mechanism
38382
D002177 D004318 Candidiasis marker/mechanism
17103211
D006332 D004318 Cardiomegaly therapeutic
18089841
D002637 D004318 Chest Pain marker/mechanism
13130401
D002690 D004318 Chlamydia Infections therapeutic
10534208
D016770 D004318 Ciliophora Infections therapeutic
12113305
D019970 D004318 Cocaine-Related Disorders therapeutic
19629758
D017714 D004318 Community-Acquired Infections therapeutic
9145823
D003711 D004318 Demyelinating Diseases marker/mechanism
8902563
D003715 D004318 Dengue therapeutic
17502914
D003866 D004318 Depressive Disorder marker/mechanism
13130401
D003967 D004318 Diarrhea marker/mechanism
10879639
13130401
D004184 D004318 Dirofilariasis therapeutic
18930598
D006970 D004318 Disorders of Excessive Somnolence marker/mechanism
30746
17103211
D004244 D004318 Dizziness marker/mechanism
17103211
21053638
D003875 D004318 Drug Eruptions marker/mechanism
138789
D004342 D004318 Drug Hypersensitivity marker/mechanism
6268571
18332631
D056486 D004318 Drug-Induced Liver Injury marker/mechanism
22331495
D064420 D004318 Drug-Related Side Effects and Adverse Reactions marker/mechanism
9004058
D004401 D004318 Dysarthria marker/mechanism
9004058
D004697 D004318 Endocarditis, Bacterial therapeutic
9868693
D004802 D004318 Eosinophilia marker/mechanism
9145823
C538499 D004318 Erythema migrans therapeutic
10879639
D005076 D004318 Exanthema marker/mechanism
6268571
D005128 D004318 Eye Diseases therapeutic
19061933
D005221 D004318 Fatigue marker/mechanism
9004058
13130401
D005393 D004318 Fish Diseases therapeutic
12113305
D005402 D004318 Fistula therapeutic
8902563
9527117
D020234 D004318 Gait Ataxia marker/mechanism
9004058
D005767 D004318 Gastrointestinal Diseases marker/mechanism
16291409
17103211
17826578
D006192 D004318 Haemophilus Infections therapeutic
30746
D006261 D004318 Headache marker/mechanism
10534208
17103211
D034381 D004318 Hearing Loss marker/mechanism
7855666
D006606 D004318 Hiccup marker/mechanism
8619448
D006943 D004318 Hyperglycemia marker/mechanism
9145823
D006973 D004318 Hypertension marker/mechanism
13130401
D006987 D004318 Hypesthesia marker/mechanism
11952888
D007010 D004318 Hyponatremia therapeutic
7635859
D017674 D004318 Hypophosphatemia marker/mechanism
3277077
D019586 D004318 Intracranial Hypertension marker/mechanism
12649241
17103211
D007970 D004318 Leukopenia marker/mechanism
9145823
D008107 D004318 Liver Diseases marker/mechanism
13130401
D017114 D004318 Liver Failure, Acute marker/mechanism
19539102
D008193 D004318 Lyme Disease therapeutic
9332695
17103211
D008223 D004318 Lymphoma therapeutic
20133848
D008231 D004318 Lymphopenia marker/mechanism
9145823
D008288 D004318 Malaria therapeutic
8619448
12649241
17826578
D008382 D004318 Marfan Syndrome therapeutic
18178469
D008569 D004318 Memory Disorders marker/mechanism
9004058
D009120 D004318 Muscle Cramp marker/mechanism
11952888
D009325 D004318 Nausea marker/mechanism
30746
10534208
10879639
13130401
D009422 D004318 Nervous System Diseases marker/mechanism
8902563
9527117
D009503 D004318 Neutropenia marker/mechanism
9145823
D000857 D004318 Olfaction Disorders marker/mechanism
2139490
14676161
D009896 D004318 Optic Atrophy marker/mechanism
12649241
D010003 D004318 Osteoarthritis therapeutic
17267227
D010211 D004318 Papilledema marker/mechanism
12649241
D010243 D004318 Paralysis marker/mechanism
9527117
D010292 D004318 Paresthesia marker/mechanism
5026677
D034161 D004318 Pelvic Infection therapeutic
17103211
D010391 D004318 Pemphigoid, Bullous therapeutic
11026799
D010518 D004318 Periodontitis therapeutic
11089368
D010689 D004318 Phlebitis marker/mechanism
138789
D010787 D004318 Photosensitivity Disorders marker/mechanism
5026677
9145823
17103211
D010859 D004318 Pigmentation Disorders marker/mechanism
17103211
D011008 D004318 Pneumococcal Infections therapeutic
30746
D011014 D004318 Pneumonia therapeutic
9145823
D011115 D004318 Polyneuropathies marker/mechanism
11952888
D011475 D004318 Prosthesis Failure therapeutic
15741211
D011507 D004318 Proteinuria therapeutic
12900822
D011537 D004318 Pruritus marker/mechanism
138789
18332631
D011559 D004318 Pseudotumor Cerebri marker/mechanism
15210900
19204639
19345447
D011625 D004318 Pterygium therapeutic
22724003
D012141 D004318 Respiratory Tract Infections therapeutic
138789
17103211
D012393 D004318 Rosacea therapeutic
19588640
20645521
21916272
D012640 D004318 Seizures marker/mechanism
9190241
D012871 D004318 Skin Diseases marker/mechanism
therapeutic
2139490
16800173
17826578
D012874 D004318 Skin Diseases, Infectious therapeutic
17103211
D013492 D004318 Suppuration marker/mechanism
6268571
D013575 D004318 Syncope marker/mechanism
9145823
D013587 D004318 Syphilis therapeutic
8108759
D014075 D004318 Tooth Discoloration marker/mechanism
17103211
D014202 D004318 Tremor marker/mechanism
9004058
D014526 D004318 Urethritis therapeutic
10534208
D014552 D004318 Urinary Tract Infections therapeutic
17103211
D002575 D004318 Uterine Cervicitis therapeutic
10534208
D014623 D004318 Vaginal Diseases marker/mechanism
17826578
D018366 D004318 Vasculitis, Leukocytoclastic, Cutaneous marker/mechanism
6268571
D015354 D004318 Vision, Low marker/mechanism
12649241
15210900
D014839 D004318 Vomiting marker/mechanism
10534208
12649241