KCF-S cluster No. 5500 (2 metabolites)

• Index
• Plant Species
• KEGG BRITE br08003
• Metabolite list (2)
• Human Protein
  / Gene in interactions
• Related Diseases

Plant Species

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Cumulative plant class count

class name	count

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Cumulative family count

class name	count
Streptomycetaceae	2

KEGG BRITE br08003

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Categories (0)

br08003 Category	# of metabolite

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metabolites link (0)

br08003 Category	KEGG ID	KNApSAcK ID

Metabolite list (2)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	figure
C00017127	Unidox / GS 3065 / Doxycen / Monodox / Ronaxan / Doxinyl / Liviatin / Pulmodox / Tolexine / Doxivetin / Dentistar / Hydramycin / Vibramycin / Medeomycin / Vibravenos / Vibramycine / Doxycycline / Deoxymykoin / Vibranos SF / Vibraveineuse / Doxytetracycline / alpha-Doxycycline / 6-Deoxyoxytetracycline / alpha-6-Deoxyoxytetracycline	CHEMBL1433 CHEMBL1372176 CHEMBL1616405 CHEMBL1624566	D004318	114 / 51 / 40	14 / 102
C00018686	Vectrin / Minocin / Periocline / NSC 141993 / Klinomycin / Minocycline chloride / Minocycline hydrochloride	CHEMBL1434 CHEMBL1515060 CHEMBL1619602		22 / 5 / 5

Human Protein / Gene in interactions

117 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P10635	Cytochrome P450 2D6	Cytochrome P450 2D6	C00017127 C00018686	1 / 0
Q9NUW8	Tyrosyl-DNA phosphodiesterase 1	Enzyme	C00017127 C00018686	1 / 1
Q96KQ7	Histone-lysine N-methyltransferase EHMT2	Enzyme	C00017127 C00018686	0 / 0
Q9UM07	Protein-arginine deiminase type-4	Enzyme	C00017127 C00018686	1 / 0
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00017127 C00018686	0 / 1
P33261	Cytochrome P450 2C19	Cytochrome P450 2C19	C00017127 C00018686	1 / 1
P08588	Beta-1 adrenergic receptor	Adrenergic receptor	C00017127 C00018686	1 / 0
P07550	Beta-2 adrenergic receptor	Adrenergic receptor	C00017127 C00018686	0 / 1
P05177	Cytochrome P450 1A2	Cytochrome P450 1A2	C00017127 C00018686	0 / 0
O94782	Ubiquitin carboxyl-terminal hydrolase 1	Enzyme	C00017127 C00018686	0 / 0
Q4U2R8	Solute carrier family 22 member 6	Antiporter	C00017127 C00018686	0 / 0
P55085	Proteinase-activated receptor 2	Protease-activated receptor	C00017127 C00018686	0 / 0
Q8TCC7	Solute carrier family 22 member 8	Antiporter	C00017127 C00018686	0 / 0
Q16665	Hypoxia-inducible factor 1-alpha	Transcription Factor	C00017127 C00018686	0 / 0
P11712	Cytochrome P450 2C9	Cytochrome P450 2C9	C00017127 C00018686	0 / 1
O75604	Ubiquitin carboxyl-terminal hydrolase 2	Enzyme	C00017127 C00018686	0 / 0
P02768	Serum albumin	Secreted protein	C00017127 C00018686	0 / 0
P13945	Beta-3 adrenergic receptor	Adrenergic receptor	C00017127 C00018686	0 / 0
Q9NSA0	Solute carrier family 22 member 11	Transporter	C00017127 C00018686	0 / 0
P00918	Carbonic anhydrase 2	Lyase	C00017127	1 / 2
P21397	Amine oxidase [flavin-containing] A	Oxidoreductase	C00017127	1 / 1
P25021	Histamine H2 receptor	Histamine receptor	C00017127	0 / 0
P35367	Histamine H1 receptor	Histamine receptor	C00017127	0 / 0
Q01959	Sodium-dependent dopamine transporter	Dopamine	C00017127	1 / 0
P08912	Muscarinic acetylcholine receptor M5	Acetylcholine receptor	C00017127	0 / 0
P18825	Alpha-2C adrenergic receptor	Adrenergic receptor	C00017127	0 / 0
P16473	Thyrotropin receptor	Glycohormone receptor	C00017127	3 / 2
Q9Y694	Solute carrier family 22 member 7	Unclassified protein	C00018686	0 / 0
P25024	C-X-C chemokine receptor type 1	CXC chemokine receptor	C00017127	0 / 0
P06241	Tyrosine-protein kinase Fyn	Src	C00017127	0 / 0
Q08209	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	Ser_Thr	C00017127	0 / 0
O15245	Solute carrier family 22 member 1	Drug uniporter	C00017127	0 / 0
P00533	Epidermal growth factor receptor	TK tyrosine-protein kinase EGFR subfamily	C00017127	1 / 8
P11473	Vitamin D3 receptor	NR1I1	C00017127	2 / 3
P14416	D(2) dopamine receptor	Dopamine receptor	C00017127	2 / 0
P23219	Prostaglandin G/H synthase 1	Oxidoreductase	C00017127	0 / 0
P37288	Vasopressin V1a receptor	Vasopressin and oxytocin receptor	C00017127	0 / 0
P41145	Kappa-type opioid receptor	Opioid receptor	C00017127	0 / 0
Q9Y271	Cysteinyl leukotriene receptor 1	Leukotriene receptor	C00017127	0 / 0
P29274	Adenosine receptor A2a	Adenosine receptor	C00017127	0 / 0
P25929	Neuropeptide Y receptor type 1	Neuropeptide Y receptor	C00017127	0 / 0
P50052	Type-2 angiotensin II receptor	Angiotensin receptor	C00017127	1 / 1
P17948	Vascular endothelial growth factor receptor 1	Vegfr	C00017127	0 / 0
P41968	Melanocortin receptor 3	Melanocortin receptor	C00017127	1 / 0
P11509	Cytochrome P450 2A6	Cytochrome P450 2A6	C00017127	0 / 0
P14780	Matrix metalloproteinase-9	M10A	C00017127	2 / 2
P39748	Flap endonuclease 1	Enzyme	C00017127	0 / 0
Q92830	Histone acetyltransferase KAT2A	Enzyme	C00017127	0 / 0
P27361	Mitogen-activated protein kinase 3	Erk	C00017127	0 / 0
P04035	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Oxidoreductase	C00017127	0 / 0
P08913	Alpha-2A adrenergic receptor	Adrenergic receptor	C00017127	0 / 0
P21917	D(4) dopamine receptor	Dopamine receptor	C00017127	0 / 0
P30988	Calcitonin receptor	Calcitonin receptor	C00017127	0 / 0
P35462	D(3) dopamine receptor	Dopamine receptor	C00017127	1 / 0
P41143	Delta-type opioid receptor	Opioid receptor	C00017127	0 / 0
Q92731	Estrogen receptor beta	NR3A2	C00017127	0 / 1
P41595	5-hydroxytryptamine receptor 2B	Serotonin receptor	C00017127	0 / 0
P25101	Endothelin-1 receptor	Endothelin receptor	C00017127	0 / 0
P30411	B2 bradykinin receptor	Bradykinin receptor	C00017127	0 / 0
P32245	Melanocortin receptor 4	Melanocortin receptor	C00017127	1 / 0
P32238	Cholecystokinin receptor type A	Cholecystokinin receptor	C00017127	0 / 0
P08311	Cathepsin G	S1A	C00017127	0 / 0
Q99720	Sigma non-opioid intracellular receptor 1	Membrane receptor	C00017127	1 / 0
P03956	Interstitial collagenase	M10A	C00017127	0 / 1
P32241	Vasoactive intestinal polypeptide receptor 1	Vasoactive intestinal peptide receptor	C00017127	0 / 0
P17252	Protein kinase C alpha type	Alpha	C00017127	0 / 0
P29466	Caspase-1	C14	C00017127	0 / 0
P83916	Chromobox protein homolog 1	Unclassified protein	C00017127	0 / 0
P22894	Neutrophil collagenase	M10A	C00017127	0 / 0
P04150	Glucocorticoid receptor	NR3C1	C00017127	0 / 1
P08172	Muscarinic acetylcholine receptor M2	Acetylcholine receptor	C00017127	2 / 0
P11229	Muscarinic acetylcholine receptor M1	Acetylcholine receptor	C00017127	0 / 0
P21554	Cannabinoid receptor 1	Cannabinoid receptor	C00017127	0 / 0
P31645	Sodium-dependent serotonin transporter	Serotonin	C00017127	2 / 0
P04626	Receptor tyrosine-protein kinase erbB-2	TK tyrosine-protein kinase EGFR subfamily	C00017127	5 / 9
P20309	Muscarinic acetylcholine receptor M3	Acetylcholine receptor	C00017127	1 / 0
P21452	Substance-K receptor	Neurokinin receptor	C00017127	0 / 0
P51679	C-C chemokine receptor type 4	CC chemokine receptor	C00017127	0 / 0
P51681	C-C chemokine receptor type 5	CC chemokine receptor	C00017127	3 / 0
P50406	5-hydroxytryptamine receptor 6	Serotonin receptor	C00017127	0 / 0
P45452	Collagenase 3	M10A	C00017127	1 / 1
P41597	C-C chemokine receptor type 2	CC chemokine receptor	C00017127	1 / 0
P28482	Mitogen-activated protein kinase 1	Erk	C00017127	0 / 0
P08575	Receptor-type tyrosine-protein phosphatase C	Enzyme	C00017127	2 / 1
P49146	Neuropeptide Y receptor type 2	Neuropeptide Y receptor	C00017127	0 / 0
P08253	72 kDa type IV collagenase	M10A	C00017127	1 / 3
Q99714	3-hydroxyacyl-CoA dehydrogenase type-2	Enzyme	C00017127	3 / 3
Q16539	Mitogen-activated protein kinase 14	p38	C00017127	0 / 0
P03372	Estrogen receptor	NR3A1	C00017127	1 / 1
P33765	Adenosine receptor A3	Adenosine receptor	C00017127	0 / 0
P22303	Acetylcholinesterase	Hydrolase	C00017127	1 / 0
P28223	5-hydroxytryptamine receptor 2A	Serotonin receptor	C00017127	0 / 0
P28335	5-hydroxytryptamine receptor 2C	Serotonin receptor	C00017127	0 / 0
P35372	Mu-type opioid receptor	Opioid receptor	C00017127	0 / 0
P08173	Muscarinic acetylcholine receptor M4	Acetylcholine receptor	C00017127	0 / 0
P25103	Substance-P receptor	Neurokinin receptor	C00017127	0 / 0
P25105	Platelet-activating factor receptor	PAF receptor	C00017127	0 / 0
P33032	Melanocortin receptor 5	Melanocortin receptor	C00017127	0 / 0
P08246	Neutrophil elastase	S1A	C00017127	2 / 1
Q12809	Potassium voltage-gated channel subfamily H member 2	KCNH, Kv10-12.x (Ether-a-go-go)	C00017127	2 / 2
P05181	Cytochrome P450 2E1	Cytochrome P450 2E1	C00017127	0 / 0
P27695	DNA-(apurinic or apyrimidinic site) lyase	Enzyme	C00018686	0 / 0
P35354	Prostaglandin G/H synthase 2	Oxidoreductase	C00017127	0 / 3
Q16236	Nuclear factor erythroid 2-related factor 2	Unclassified protein	C00017127	0 / 0
P23975	Sodium-dependent noradrenaline transporter	Norepinephrine	C00017127	1 / 1
P25100	Alpha-1D adrenergic receptor	Adrenergic receptor	C00017127	0 / 0
P30542	Adenosine receptor A1	Adenosine receptor	C00017127	0 / 0
P18089	Alpha-2B adrenergic receptor	Adrenergic receptor	C00017127	0 / 0
P24557	Thromboxane-A synthase	Cytochrome P450 5A1	C00017127	1 / 1
P06239	Tyrosine-protein kinase Lck	Src	C00017127	0 / 1
P25025	C-X-C chemokine receptor type 2	CXC chemokine receptor	C00017127	0 / 0
P08254	Stromelysin-1	M10A	C00017127	1 / 0
Q9UBT6	DNA polymerase kappa	Enzyme	C00017127	0 / 0
B2RXH2	Lysine-specific demethylase 4E	Enzyme	C00018686	0 / 0
P21728	D(1A) dopamine receptor	Dopamine receptor	C00017127	0 / 0
P49798	Regulator of G-protein signaling 4	Unclassified protein	C00017127	2 / 0
O76074	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE_5A	C00017127	0 / 0

14 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
5243	ABCB1, ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1	ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44)	C00017127
196	AHR, bHLHe76	aryl hydrocarbon receptor	C00017127
1545	CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1	cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1)	C00017127
3553	IL1B, IL-1, IL1-BETA, IL1F2	interleukin 1, beta	C00017127
3576	IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1	interleukin 8	C00017127
4322	MMP13, CLG3, MANDP1	matrix metallopeptidase 13 (collagenase 3) (EC:3.4.24.-)	C00017127
4313	MMP2, CLG4, CLG4A, MMP-II, MONA, TBE-1	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24)	C00017127
4314	MMP3, CHDS6, MMP-3, SL-1, STMY, STMY1, STR1	matrix metallopeptidase 3 (stromelysin 1, progelatinase) (EC:3.4.24.17)	C00017127
4317	MMP8, CLG1, HNC, MMP-8, PMNL-CL	matrix metallopeptidase 8 (neutrophil collagenase) (EC:3.4.24.34)	C00017127
4318	MMP9, CLG4B, GELB, MANDP2, MMP-9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35)	C00017127
9356	SLC22A6, HOAT1, OAT1, PAHT, ROAT1	solute carrier family 22 (organic anion transporter), member 6	C00017127
7124	TNF, DIF, TNF-alpha, TNFA, TNFSF2	tumor necrosis factor	C00017127
54575	UGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J	UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17)	C00017127
54576	UGT1A8, UDPGT, UDPGT_1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H	UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17)	C00017127

Related Diseases

Diseases related to proteins in ChEMBL interactions

Diseases related to CTD interactions