KNApSAcK Metabolite C00018686
Metabolite
KNApSAcK Entry
| id | C00018686 |
|---|---|
| Name | Vectrin / Minocin / Periocline / NSC 141993 / Klinomycin / Minocycline chloride / Minocycline hydrochloride |
| CAS RN | 13614-98-7 |
| Standard InChI | InChI=1S/C23H27N3O7/c1-25(2)12-5-6-13(27)15-10(12)7-9-8-11-17(26(3)4)19(29)16(22(24)32)21(31)23(11,33)20(30)14(9)18(15)28/h5-6,9,11,17,27,29-30,33H,7-8H2,1-4H3,(H2,24,32)/t9-,11-,17-,23-/m0/s1 |
| Standard InChI (Main Layer) | InChI=1S/C23H27N3O7/c1-25(2)12-5-6-13(27)15-10(12)7-9-8-11-17(26(3)4)19(29)16(22(24)32)21(31)23(11,33)20(30)14(9)18(15)28/h5-6,9,11,17,27,29-30,33H,7-8H2,1-4H3,(H2,24,32) |
Cluster
| Phytochemical cluster | |
|---|---|
| KCF-S cluster | No. 5500 |
Link
ChEMBL
| By standard InChI | CHEMBL1434 |
|---|---|
| By standard InChI Main Layer | CHEMBL1434 CHEMBL1515060 CHEMBL1619602 |
KEGG
| By LinkDB |
|---|
CTD
| By CAS RN |
|---|
Species
Summary
Plant class
| class name | count |
|---|
Family
| family name | count |
|---|---|
| Streptomycetaceae | 1 |
List (1)
* NCBI
| KNApSAcK organism | *ID | *family | *plant class | *kingdom |
|---|---|---|---|---|
| Streptomyces I-523 | 1883 | Streptomycetaceae | Bacteria |
Human Protein / Gene in interaction
22 ChEMBL Protein in interactions
| accession | description | class description | compound | assay ID (# of activities) |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|---|
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | CHEMBL1434 CHEMBL1515060 |
CHEMBL1741321
(1)
CHEMBL2071965
(1)
|
1 / 0 |
| O75604 | Ubiquitin carboxyl-terminal hydrolase 2 | Enzyme | CHEMBL1515060 |
CHEMBL1614331
(1)
|
0 / 0 |
| Q9Y694 | Solute carrier family 22 member 7 | Unclassified protein | CHEMBL1434 |
CHEMBL2075462
(1)
|
0 / 0 |
| P02768 | Serum albumin | Secreted protein | CHEMBL1434 |
CHEMBL702885
(1)
CHEMBL1661507
(1)
CHEMBL1661516 (1) CHEMBL1661517 (1) |
0 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | CHEMBL1434 CHEMBL1515060 |
CHEMBL1741325
(1)
CHEMBL2071963
(1)
|
0 / 1 |
| Q16665 | Hypoxia-inducible factor 1-alpha | Transcription Factor | CHEMBL1515060 |
CHEMBL1614456
(1)
CHEMBL1613803
(1)
|
0 / 0 |
| Q8TCC7 | Solute carrier family 22 member 8 | Antiporter | CHEMBL1434 |
CHEMBL2076663
(1)
|
0 / 0 |
| P55085 | Proteinase-activated receptor 2 | Protease-activated receptor | CHEMBL1434 |
CHEMBL1661209
(1)
CHEMBL1661210
(1)
CHEMBL1661211 (1) CHEMBL1661212 (1) CHEMBL1661213 (1) |
0 / 0 |
| Q4U2R8 | Solute carrier family 22 member 6 | Antiporter | CHEMBL1434 |
CHEMBL2077181
(1)
|
0 / 0 |
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | CHEMBL1515060 |
CHEMBL1794467
(1)
|
0 / 0 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | CHEMBL1434 CHEMBL1515060 |
CHEMBL1741322
(1)
CHEMBL2071962
(1)
|
0 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | CHEMBL1434 CHEMBL1515060 |
CHEMBL1741323
(1)
CHEMBL2071964
(1)
|
1 / 1 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | CHEMBL1434 CHEMBL1515060 |
CHEMBL1741324
(1)
CHEMBL2071966
(1)
CHEMBL2071967 (1) |
0 / 1 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | CHEMBL1515060 |
CHEMBL1614211
(1)
|
0 / 0 |
| Q9UM07 | Protein-arginine deiminase type-4 | Enzyme | CHEMBL1434 |
CHEMBL929914
(1)
CHEMBL929915
(1)
CHEMBL929916 (1) |
1 / 0 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | CHEMBL1515060 |
CHEMBL1613914
(1)
|
0 / 0 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | CHEMBL1515060 |
CHEMBL1738442
(1)
|
0 / 0 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | CHEMBL1515060 |
CHEMBL1614364
(1)
|
1 / 1 |
| Q9NSA0 | Solute carrier family 22 member 11 | Transporter | CHEMBL1434 |
CHEMBL2075520
(1)
|
0 / 0 |
| P07550 | Beta-2 adrenergic receptor | Adrenergic receptor | CHEMBL1434 |
CHEMBL650218
(1)
|
0 / 1 |
| P08588 | Beta-1 adrenergic receptor | Adrenergic receptor | CHEMBL1434 |
CHEMBL650218
(1)
|
1 / 0 |
| P13945 | Beta-3 adrenergic receptor | Adrenergic receptor | CHEMBL1434 |
CHEMBL650218
(1)
|
0 / 0 |
Related Disease
Diseases related to proteins in ChEMBL interactions
OMIM (5)
| OMIM | preferred title | UniProt |
|---|---|---|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #607276 | Resting heart rate, variation in |
P08588
|
| #180300 | Rheumatoid arthritis; ra |
Q9UM07
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|