Species

KNApSAcK Entry

Organism name Streptomyces I-523
Genus Streptomyces
Family Streptomycetaceae
Kingdom Bacteria

NCBI taxonomy

Entry

Linked NCBI taxonomy name Streptomyces
Linked NCBI taxonomy ID 1883
Linked level genus

Family

Family in NCBI taxonomy Streptomycetaceae
ID 2062

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Bacteria
ID 2

Plant class

Plant class
ID

Metabolite list (1)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00018686 External link 512 Vectrin
/ Minocin
/ Periocline
/ NSC 141993
/ Klinomycin
/ Minocycline chloride
/ Minocycline hydrochloride
CHEMBL1434
CHEMBL1515060
CHEMBL1619602
22 / 5 / 5 No. 5500

Human Protein / Gene in interactions

22 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00018686 1 / 0
O75604 Ubiquitin carboxyl-terminal hydrolase 2 Enzyme C00018686 0 / 0
Q9Y694 Solute carrier family 22 member 7 Unclassified protein C00018686 0 / 0
P02768 Serum albumin Secreted protein C00018686 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00018686 0 / 1
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor C00018686 0 / 0
Q8TCC7 Solute carrier family 22 member 8 Antiporter C00018686 0 / 0
P55085 Proteinase-activated receptor 2 Protease-activated receptor C00018686 0 / 0
Q4U2R8 Solute carrier family 22 member 6 Antiporter C00018686 0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00018686 0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00018686 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00018686 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00018686 0 / 1
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00018686 0 / 0
Q9UM07 Protein-arginine deiminase type-4 Enzyme C00018686 1 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00018686 0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00018686 0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00018686 1 / 1
Q9NSA0 Solute carrier family 22 member 11 Transporter C00018686 0 / 0
P07550 Beta-2 adrenergic receptor Adrenergic receptor C00018686 0 / 1
P08588 Beta-1 adrenergic receptor Adrenergic receptor C00018686 1 / 0
P13945 Beta-3 adrenergic receptor Adrenergic receptor C00018686 0 / 0

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (5)

OMIM preferred title UniProt
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#607276 Resting heart rate, variation in P08588
#180300 Rheumatoid arthritis; ra Q9UM07
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8

KEGG DISEASE (5)

KEGG name UniProt
H00079 Asthma P07550 (related)
H00036 Osteosarcoma P08684 (marker)
H01205 Coumarin resistance P11712 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00063 Spinocerebellar ataxia (SCA) Q9NUW8 (related)