KNApSAcK Metabolite C00001724
Metabolite
KNApSAcK Entry
| id | C00001724 |
|---|---|
| Name | Ergotamine |
| CAS RN | 113-15-5 |
| Standard InChI | InChI=1S/C33H35N5O5/c1-32(35-29(39)21-15-23-22-10-6-11-24-28(22)20(17-34-24)16-25(23)36(2)18-21)31(41)38-26(14-19-8-4-3-5-9-19)30(40)37-13-7-12-27(37)33(38,42)43-32/h3-6,8-11,15,17,21,25-27,34,42H,7,12-14,16,18H2,1-2H3,(H,35,39)/t21-,25-,26+,27+,32-,33+/m1/s1 |
| Standard InChI (Main Layer) | InChI=1S/C33H35N5O5/c1-32(35-29(39)21-15-23-22-10-6-11-24-28(22)20(17-34-24)16-25(23)36(2)18-21)31(41)38-26(14-19-8-4-3-5-9-19)30(40)37-13-7-12-27(37)33(38,42)43-32/h3-6,8-11,15,17,21,25-27,34,42H,7,12-14,16,18H2,1-2H3,(H,35,39) |
Cluster
| Phytochemical cluster | No. 4 |
|---|---|
| KCF-S cluster | No. 271 |
Link
ChEMBL
| By standard InChI | CHEMBL442 |
|---|---|
| By standard InChI Main Layer | CHEMBL442 CHEMBL1315610 CHEMBL1402957 CHEMBL1982133 |
KEGG
| By LinkDB | C07544 |
|---|
CTD
| By CAS RN | D004878 |
|---|
Species
Summary
Plant class
| class name | count |
|---|
Family
| family name | count |
|---|---|
| Clavicipitaceae | 2 |
List (2)
* NCBI
| KNApSAcK organism | *ID | *family | *plant class | *kingdom |
|---|---|---|---|---|
| Claviceps paspali | 40601 | Clavicipitaceae | Fungi | |
| Claviceps purpurea | 5111 | Clavicipitaceae | Fungi |
Human Protein / Gene in interaction
116 ChEMBL Protein in interactions
| accession | description | class description | compound | assay ID (# of activities) |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|---|
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | CHEMBL442 CHEMBL1315610 |
CHEMBL1741321
(1)
CHEMBL1909136
(2)
|
1 / 0 |
| P21728 | D(1A) dopamine receptor | Dopamine receptor | CHEMBL442 |
CHEMBL1909139
(2)
|
0 / 0 |
| P27338 | Amine oxidase [flavin-containing] B | Oxidoreductase | CHEMBL442 |
CHEMBL965571
(1)
CHEMBL965576
(1)
|
0 / 0 |
| P35354 | Prostaglandin G/H synthase 2 | Oxidoreductase | CHEMBL442 |
CHEMBL1909131
(2)
|
0 / 3 |
| Q12809 | Potassium voltage-gated channel subfamily H member 2 | KCNH, Kv10-12.x (Ether-a-go-go) | CHEMBL442 |
CHEMBL1909190
(2)
|
2 / 2 |
| P08246 | Neutrophil elastase | S1A | CHEMBL442 |
CHEMBL1909195
(2)
|
2 / 1 |
| P33765 | Adenosine receptor A3 | Adenosine receptor | CHEMBL442 |
CHEMBL1909215
(2)
|
0 / 0 |
| Q16539 | Mitogen-activated protein kinase 14 | p38 | CHEMBL442 |
CHEMBL1909201
(2)
|
0 / 0 |
| P49146 | Neuropeptide Y receptor type 2 | Neuropeptide Y receptor | CHEMBL442 |
CHEMBL1909176
(2)
|
0 / 0 |
| P29466 | Caspase-1 | C14 | CHEMBL442 CHEMBL1402957 |
CHEMBL1614158
(1)
CHEMBL1909193
(2)
|
0 / 0 |
| P17252 | Protein kinase C alpha type | Alpha | CHEMBL442 |
CHEMBL1909198
(2)
|
0 / 0 |
| P27361 | Mitogen-activated protein kinase 3 | Erk | CHEMBL442 |
CHEMBL1909199
(2)
|
0 / 0 |
| P14780 | Matrix metalloproteinase-9 | M10A | CHEMBL442 |
CHEMBL1909197
(2)
|
2 / 2 |
| O15245 | Solute carrier family 22 member 1 | Drug uniporter | CHEMBL442 |
CHEMBL993349
(1)
|
0 / 0 |
| P10828 | Thyroid hormone receptor beta | NR1A2 | CHEMBL1402957 |
CHEMBL1613776
(1)
|
3 / 1 |
| P00918 | Carbonic anhydrase 2 | Lyase | CHEMBL442 |
CHEMBL1909123
(2)
|
1 / 2 |
| P07550 | Beta-2 adrenergic receptor | Adrenergic receptor | CHEMBL442 |
CHEMBL1909092
(2)
|
0 / 1 |
| P21397 | Amine oxidase [flavin-containing] A | Oxidoreductase | CHEMBL442 |
CHEMBL1909169
(2)
|
1 / 1 |
| P25021 | Histamine H2 receptor | Histamine receptor | CHEMBL442 |
CHEMBL1909157
(2)
|
0 / 0 |
| P28222 | 5-hydroxytryptamine receptor 1B | Serotonin receptor | CHEMBL442 |
CHEMBL1912148
(1)
|
0 / 0 |
| P35367 | Histamine H1 receptor | Histamine receptor | CHEMBL442 |
CHEMBL1909156
(2)
|
0 / 0 |
| Q01959 | Sodium-dependent dopamine transporter | Dopamine | CHEMBL442 |
CHEMBL1909143
(2)
|
1 / 0 |
| P08912 | Muscarinic acetylcholine receptor M5 | Acetylcholine receptor | CHEMBL442 |
CHEMBL1909174
(2)
|
0 / 0 |
| P18825 | Alpha-2C adrenergic receptor | Adrenergic receptor | CHEMBL442 |
CHEMBL1909090
(2)
|
0 / 0 |
| P13945 | Beta-3 adrenergic receptor | Adrenergic receptor | CHEMBL442 |
CHEMBL1909093
(2)
|
0 / 0 |
| P47898 | 5-hydroxytryptamine receptor 5A | Serotonin receptor | CHEMBL442 |
CHEMBL618072
(1)
CHEMBL618085
(1)
CHEMBL1831564 (1) |
0 / 0 |
| P08183 | Multidrug resistance protein 1 | drug | CHEMBL442 |
CHEMBL2076229
(1)
CHEMBL2076230
(1)
|
1 / 0 |
| P25024 | C-X-C chemokine receptor type 1 | CXC chemokine receptor | CHEMBL442 |
CHEMBL1909127
(2)
|
0 / 0 |
| P06241 | Tyrosine-protein kinase Fyn | Src | CHEMBL442 |
CHEMBL1909204
(2)
|
0 / 0 |
| Q08209 | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform | Ser_Thr | CHEMBL442 |
CHEMBL1909202
(2)
|
0 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | CHEMBL442 CHEMBL1315610 |
CHEMBL1741325
(1)
CHEMBL1909135
(2)
|
0 / 1 |
| P00533 | Epidermal growth factor receptor | TK tyrosine-protein kinase EGFR subfamily | CHEMBL442 |
CHEMBL1909203
(2)
|
1 / 11 |
| P11473 | Vitamin D3 receptor | NR1I1 | CHEMBL1402957 |
CHEMBL1794311
(1)
|
2 / 3 |
| P14416 | D(2) dopamine receptor | Dopamine receptor | CHEMBL442 |
CHEMBL1909140
(2)
|
2 / 0 |
| P23219 | Prostaglandin G/H synthase 1 | Oxidoreductase | CHEMBL442 |
CHEMBL1909130
(2)
|
0 / 0 |
| P37288 | Vasopressin V1a receptor | Vasopressin and oxytocin receptor | CHEMBL442 |
CHEMBL1909120
(2)
|
0 / 0 |
| P41145 | Kappa-type opioid receptor | Opioid receptor | CHEMBL442 |
CHEMBL1909181
(2)
|
0 / 0 |
| Q9Y271 | Cysteinyl leukotriene receptor 1 | Leukotriene receptor | CHEMBL442 |
CHEMBL1909164
(2)
|
0 / 0 |
| P29274 | Adenosine receptor A2a | Adenosine receptor | CHEMBL442 |
CHEMBL1909214
(2)
|
0 / 0 |
| P25929 | Neuropeptide Y receptor type 1 | Neuropeptide Y receptor | CHEMBL442 |
CHEMBL1909175
(2)
|
0 / 0 |
| P50052 | Type-2 angiotensin II receptor | Angiotensin receptor | CHEMBL442 |
CHEMBL1909096
(2)
|
1 / 1 |
| P17948 | Vascular endothelial growth factor receptor 1 | Vegfr | CHEMBL442 |
CHEMBL1909118
(2)
|
0 / 0 |
| P41968 | Melanocortin receptor 3 | Melanocortin receptor | CHEMBL442 |
CHEMBL1909166
(2)
|
1 / 0 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | CHEMBL1402957 |
CHEMBL1614458
(1)
|
0 / 0 |
| P11509 | Cytochrome P450 2A6 | Cytochrome P450 2A6 | CHEMBL442 |
CHEMBL1909133
(2)
|
0 / 0 |
| Q16665 | Hypoxia-inducible factor 1-alpha | Transcription Factor | CHEMBL1315610 |
CHEMBL1614456
(1)
CHEMBL1613803
(1)
|
0 / 0 |
| Q92830 | Histone acetyltransferase KAT2A | Enzyme | CHEMBL1402957 |
CHEMBL1738606
(1)
|
0 / 0 |
| P38398 | Breast cancer type 1 susceptibility protein | Enzyme | CHEMBL1402957 |
CHEMBL1613817
(1)
|
4 / 2 |
| P04035 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | Oxidoreductase | CHEMBL442 |
CHEMBL1909158
(2)
|
0 / 0 |
| P08913 | Alpha-2A adrenergic receptor | Adrenergic receptor | CHEMBL442 |
CHEMBL1909088
(2)
|
0 / 0 |
| P21917 | D(4) dopamine receptor | Dopamine receptor | CHEMBL442 |
CHEMBL1909142
(2)
|
0 / 0 |
| P30988 | Calcitonin receptor | Calcitonin receptor | CHEMBL442 |
CHEMBL1909101
(2)
|
0 / 0 |
| P35462 | D(3) dopamine receptor | Dopamine receptor | CHEMBL442 |
CHEMBL1909141
(2)
|
1 / 0 |
| P41143 | Delta-type opioid receptor | Opioid receptor | CHEMBL442 |
CHEMBL1909180
(2)
|
0 / 0 |
| Q92731 | Estrogen receptor beta | NR3A2 | CHEMBL442 |
CHEMBL1909146
(2)
|
0 / 1 |
| P41595 | 5-hydroxytryptamine receptor 2B | Serotonin receptor | CHEMBL442 |
CHEMBL1909104
(2)
|
0 / 0 |
| P25101 | Endothelin-1 receptor | Endothelin receptor | CHEMBL442 |
CHEMBL1909144
(2)
|
0 / 0 |
| P30411 | B2 bradykinin receptor | Bradykinin receptor | CHEMBL442 |
CHEMBL1909100
(2)
|
0 / 0 |
| P32245 | Melanocortin receptor 4 | Melanocortin receptor | CHEMBL442 |
CHEMBL1909167
(2)
|
1 / 0 |
| P32238 | Cholecystokinin receptor type A | Cholecystokinin receptor | CHEMBL442 |
CHEMBL1909129
(2)
|
0 / 0 |
| P08311 | Cathepsin G | S1A | CHEMBL442 |
CHEMBL1909194
(2)
|
0 / 0 |
| Q99720 | Sigma non-opioid intracellular receptor 1 | Membrane receptor | CHEMBL442 |
CHEMBL1909110
(2)
|
1 / 0 |
| P03956 | Interstitial collagenase | M10A | CHEMBL442 |
CHEMBL1909196
(2)
|
0 / 1 |
| P32241 | Vasoactive intestinal polypeptide receptor 1 | Vasoactive intestinal peptide receptor | CHEMBL442 |
CHEMBL1909119
(2)
|
0 / 0 |
| Q9HC16 | DNA dC->dU-editing enzyme APOBEC-3G | Enzyme | CHEMBL1402957 |
CHEMBL1794342
(1)
|
0 / 0 |
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | CHEMBL1402957 |
CHEMBL1794467
(1)
|
0 / 0 |
| P04150 | Glucocorticoid receptor | NR3C1 | CHEMBL442 |
CHEMBL1909150
(2)
|
0 / 1 |
| P08172 | Muscarinic acetylcholine receptor M2 | Acetylcholine receptor | CHEMBL442 |
CHEMBL1909171
(2)
|
2 / 0 |
| P11229 | Muscarinic acetylcholine receptor M1 | Acetylcholine receptor | CHEMBL442 |
CHEMBL1909170
(2)
|
0 / 0 |
| P21554 | Cannabinoid receptor 1 | Cannabinoid receptor | CHEMBL442 |
CHEMBL1909122
(2)
|
0 / 0 |
| P31645 | Sodium-dependent serotonin transporter | Serotonin | CHEMBL442 |
CHEMBL1909109
(2)
|
2 / 0 |
| P04626 | Receptor tyrosine-protein kinase erbB-2 | TK tyrosine-protein kinase EGFR subfamily | CHEMBL442 |
CHEMBL1909205
(2)
|
5 / 10 |
| P20309 | Muscarinic acetylcholine receptor M3 | Acetylcholine receptor | CHEMBL442 |
CHEMBL1909172
(2)
|
1 / 0 |
| P21452 | Substance-K receptor | Neurokinin receptor | CHEMBL442 |
CHEMBL1909114
(2)
|
0 / 0 |
| P51679 | C-C chemokine receptor type 4 | CC chemokine receptor | CHEMBL442 |
CHEMBL1909125
(2)
|
0 / 0 |
| P51681 | C-C chemokine receptor type 5 | CC chemokine receptor | CHEMBL442 |
CHEMBL1909126
(2)
|
3 / 0 |
| P50406 | 5-hydroxytryptamine receptor 6 | Serotonin receptor | CHEMBL442 |
CHEMBL1909108
(2)
|
0 / 0 |
| P41597 | C-C chemokine receptor type 2 | CC chemokine receptor | CHEMBL442 |
CHEMBL1909124
(2)
|
1 / 0 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | CHEMBL442 CHEMBL1402957 |
CHEMBL1613808
(1)
CHEMBL1909200
(2)
|
0 / 0 |
| P08575 | Receptor-type tyrosine-protein phosphatase C | Enzyme | CHEMBL442 |
CHEMBL1909207
(2)
|
2 / 1 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | CHEMBL442 CHEMBL1315610 |
CHEMBL1741322
(1)
CHEMBL1909132
(2)
|
0 / 0 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | CHEMBL1402957 |
CHEMBL1613910
(1)
|
3 / 3 |
| O76074 | cGMP-specific 3',5'-cyclic phosphodiesterase | PDE_5A | CHEMBL442 |
CHEMBL1909186
(2)
|
0 / 0 |
| P03372 | Estrogen receptor | NR3A1 | CHEMBL442 |
CHEMBL1909145
(2)
|
1 / 1 |
| P08588 | Beta-1 adrenergic receptor | Adrenergic receptor | CHEMBL442 |
CHEMBL1909091
(2)
|
1 / 0 |
| P22303 | Acetylcholinesterase | Hydrolase | CHEMBL442 |
CHEMBL1909212
(2)
|
1 / 0 |
| P28223 | 5-hydroxytryptamine receptor 2A | Serotonin receptor | CHEMBL442 |
CHEMBL1909211
(2)
|
0 / 0 |
| P28335 | 5-hydroxytryptamine receptor 2C | Serotonin receptor | CHEMBL442 |
CHEMBL1909105
(2)
|
0 / 0 |
| P35372 | Mu-type opioid receptor | Opioid receptor | CHEMBL442 |
CHEMBL1909182
(2)
|
0 / 0 |
| P08173 | Muscarinic acetylcholine receptor M4 | Acetylcholine receptor | CHEMBL442 |
CHEMBL1909173
(2)
|
0 / 0 |
| P25103 | Substance-P receptor | Neurokinin receptor | CHEMBL442 |
CHEMBL1909113
(2)
|
0 / 0 |
| P25105 | Platelet-activating factor receptor | PAF receptor | CHEMBL442 |
CHEMBL1909187
(2)
|
0 / 0 |
| P33032 | Melanocortin receptor 5 | Melanocortin receptor | CHEMBL442 |
CHEMBL1909168
(2)
|
0 / 0 |
| P55210 | Caspase-7 | C14 | CHEMBL1402957 |
CHEMBL1613779
(1)
|
0 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | CHEMBL442 CHEMBL1315610 |
CHEMBL1741323
(1)
CHEMBL1909134
(2)
|
1 / 1 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | CHEMBL442 CHEMBL1315610 CHEMBL1402957 |
CHEMBL1614108
(2)
CHEMBL1613886
(2)
CHEMBL1741324 (1) CHEMBL1743273 (1) CHEMBL1909138 (2) |
0 / 1 |
| P05181 | Cytochrome P450 2E1 | Cytochrome P450 2E1 | CHEMBL442 |
CHEMBL1909137
(2)
|
0 / 0 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | CHEMBL1402957 |
CHEMBL1614211
(1)
|
0 / 0 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | CHEMBL1402957 |
CHEMBL1614250
(1)
CHEMBL1614421
(1)
CHEMBL1614502 (1) |
4 / 3 |
| P23975 | Sodium-dependent noradrenaline transporter | Norepinephrine | CHEMBL442 |
CHEMBL1909094
(2)
|
1 / 1 |
| P25100 | Alpha-1D adrenergic receptor | Adrenergic receptor | CHEMBL442 |
CHEMBL1909087
(2)
|
0 / 0 |
| P28221 | 5-hydroxytryptamine receptor 1D | Serotonin receptor | CHEMBL442 |
CHEMBL616927
(1)
CHEMBL1831560
(1)
CHEMBL1912147 (1) |
0 / 0 |
| P30542 | Adenosine receptor A1 | Adenosine receptor | CHEMBL442 |
CHEMBL1909213
(2)
|
0 / 0 |
| P18089 | Alpha-2B adrenergic receptor | Adrenergic receptor | CHEMBL442 |
CHEMBL1909089
(2)
|
0 / 0 |
| P24557 | Thromboxane-A synthase | Cytochrome P450 5A1 | CHEMBL442 |
CHEMBL1909116
(2)
|
1 / 1 |
| P06239 | Tyrosine-protein kinase Lck | Src | CHEMBL442 |
CHEMBL1909206
(2)
|
0 / 1 |
| P25025 | C-X-C chemokine receptor type 2 | CXC chemokine receptor | CHEMBL442 |
CHEMBL1909128
(2)
|
0 / 0 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | CHEMBL1402957 |
CHEMBL1794536
(1)
|
0 / 0 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | CHEMBL1402957 |
CHEMBL1613914
(1)
|
0 / 0 |
| P46063 | ATP-dependent DNA helicase Q1 | Enzyme | CHEMBL1402957 |
CHEMBL1613829
(1)
CHEMBL1613928
(1)
|
0 / 0 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | CHEMBL1402957 |
CHEMBL1614364
(1)
|
1 / 1 |
| O00255 | Menin | Unclassified protein | CHEMBL1402957 |
CHEMBL1614257
(1)
CHEMBL1614531
(1)
|
2 / 5 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | CHEMBL1402957 |
CHEMBL1614257
(1)
CHEMBL1614531
(1)
|
1 / 3 |
| Q13951 | Core-binding factor subunit beta | Unclassified protein | CHEMBL1402957 |
CHEMBL1613933
(1)
|
0 / 1 |
| Q01196 | Runt-related transcription factor 1 | Unclassified protein | CHEMBL1402957 |
CHEMBL1613933
(1)
|
1 / 6 |
| Q8N6T7 | NAD-dependent protein deacetylase sirtuin-6 | Enzyme | CHEMBL1982133 |
CHEMBL2211912
(1)
|
0 / 0 |
CTD interaction (2)
| compound | gene | gene name | gene description | interaction | interaction type | form |
reference
pmid |
|---|---|---|---|---|---|---|---|
| D004878 | 836 |
CASP3
CPP32 CPP32B SCA-1 |
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) | Ergotamine results in increased activity of CASP3 protein |
increases activity
|
protein |
21295106
|
| D004878 | 3357 |
HTR2B
5-HT(2B) 5-HT2B |
5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled | Ergotamine binds to and results in increased activity of HTR2B protein |
affects binding
/ increases activity |
protein |
11104741
|
Related Disease
Diseases related to proteins in ChEMBL interactions
OMIM (57)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #100100 | Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism |
P20309
|
| #103780 | Alcohol dependence |
P08172
P14416 P31645 |
| #614373 | Amyotrophic lateral sclerosis 16, juvenile; als16 |
Q99720
|
| #602025 | Body mass index quantitative trait locus 9; bmiq9 |
P41968
|
| #114480 | Breast cancer |
P38398
|
| #604370 | Breast-ovarian cancer, familial, susceptibility to, 1; brovca1 |
P38398
|
| #300615 | Brunner syndrome |
P21397
|
| #162800 | Cyclic neutropenia |
P08246
|
| #612522 | Diabetes mellitus, insulin-dependent, 22; iddm22 |
P51681
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #615363 | Estrogen resistance; estrr |
P03372
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #613659 | Gastric cancer |
P04626
|
| #137215 | Gastric cancer, hereditary diffuse; hdgc |
P04626
|
| #231095 | Ghosal hematodiaphyseal dysplasia; ghdd |
P24557
|
| #137800 | Glioma susceptibility 1; glm1 |
P04626
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #609423 | Human immunodeficiency virus type 1, susceptibility to |
P41597
P51681 |
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #612244 | Inflammatory bowel disease 13; ibd13 |
P08183
|
| #603932 | Intervertebral disc disease; idd |
P14780
|
| #613688 | Long qt syndrome 2; lqt2 |
Q12809
|
| #211980 | Lung cancer |
P00533
P04626 |
| #608516 | Major depressive disorder; mdd |
P08172
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| %300852 | Mental retardation, x-linked 88; mrx88 |
P50052
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #613073 | Metaphyseal anadysplasia 2; mandp2 |
P14780
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #126200 | Multiple sclerosis, susceptibility to; ms |
P08575
|
| #607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
| #159900 | Myoclonic dystonia |
P14416
|
| #202700 | Neutropenia, severe congenital, 1, autosomal dominant; scn1 |
P08246
|
| #601665 | Obesity |
P32245
|
| #164230 | Obsessive-compulsive disorder; ocd |
P31645
|
| #604715 | Orthostatic intolerance |
P23975
|
| #259730 | Osteopetrosis, autosomal recessive 3; optb3 |
P00918
|
| #167000 | Ovarian cancer |
P04626
P38398 |
| #614320 | Pancreatic cancer, susceptibility to, 4; pnca4 |
P38398
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #613135 | Parkinsonism-dystonia, infantile; pkdys |
Q01959
|
| #172700 | Pick disease of brain |
P10636
|
| #601399 | Platelet disorder, familial, with associated myeloid malignancy |
Q01196
|
| #607276 | Resting heart rate, variation in |
P08588
|
| #608971 | Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive |
P08575
|
| #609620 | Short qt syndrome 1; sqt1 |
Q12809
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #188570 | Thyroid hormone resistance, generalized, autosomal dominant; grth |
P10828
|
| #274300 | Thyroid hormone resistance, generalized, autosomal recessive; grth |
P10828
|
| #145650 | Thyroid hormone resistance, selective pituitary; prth |
P10828
|
| #190300 | Tremor, hereditary essential, 1; etm1 |
P35462
|
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
| #610379 | West nile virus, susceptibility to |
P51681
|
| #112100 | Yt blood group antigen |
P22303
|
KEGG DISEASE (51)
| KEGG | disease name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
|
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00016 | Oral cancer |
P00533
(related)
P00533 (marker) |
| H00017 | Esophageal cancer |
P00533
(related)
P35354 (related) |
| H00018 | Gastric cancer |
P00533
(related)
P04626 (related) |
| H00022 | Bladder cancer |
P00533
(related)
P04626 (related) |
| H00028 | Choriocarcinoma |
P00533
(related)
P03956 (related) P04626 (related) |
| H00030 | Cervical cancer |
P00533
(related)
P04626 (related) |
| H00042 | Glioma |
P00533
(related)
P00533 (marker) |
| H00055 | Laryngeal cancer |
P00533
(related)
P00533 (marker) |
| H00241 | Combined proximal and distal renal tubular acidosis (RTA type 3) |
P00918
(related)
|
| H00436 | Osteopetrosis |
P00918
(related)
|
| H00026 | Endometrial Cancer |
P03372
(marker)
P04626 (related) Q92731 (marker) |
| H00599 | 46,XX disorders of sex development (Disorders related to androgen excess) |
P04150
(related)
|
| H00019 | Pancreatic cancer |
P04626
(related)
|
| H00027 | Ovarian cancer |
P04626
(related)
P38398 (related) |
| H00031 | Breast cancer |
P04626
(related)
P04626 (marker) P38398 (related) |
| H00046 | Cholangiocarcinoma |
P04626
(related)
P35354 (related) |
| H00093 | Combined immunodeficiencies (CIDs) |
P06239
(related)
|
| H00079 | Asthma |
P07550
(related)
|
| H00100 | Neutropenic disorders |
P08246
(related)
|
| H00091 | T-B+Severe combined immunodeficiencies (SCIDs) |
P08575
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00249 | Thyroid hormone resistance syndrome |
P10828
(related)
|
| H00342 | Tuberculosis |
P11473
(related)
|
| H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
| H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00025 | Penile cancer |
P14780
(related)
P35354 (related) |
| H00479 | Metaphyseal dysplasias |
P14780
(related)
|
| H00548 | Brunner syndrome |
P21397
(related)
|
| H01031 | Orthostatic intolerance (OI) |
P23975
(related)
|
| H00490 | Diaphyseal dysplasia with anemia (Ghosal) |
P24557
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00480 | Non-syndromic X-linked mental retardation |
P50052
(related)
Q99714 (related) |
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q01196
(related)
Q01196 (marker) Q03164 (related) Q03164 (marker) |
| H00003 | Acute myeloid leukemia (AML) |
Q01196
(related)
Q01196 (marker) Q13951 (marker) |
| H00004 | Chronic myeloid leukemia (CML) |
Q01196
(related)
|
| H00978 | Thrombocytopenia (THC) |
Q01196
(related)
|
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00720 | Long QT syndrome |
Q12809
(related)
|
| H00725 | Short QT syndrome |
Q12809
(related)
|
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q9NUW8
(related)
|
Diseases related to CTD interactions
73 disease from interactions of metabolites
| MeSH disease | OMIM | compound | disease name | evidence type |
reference
pmid |
|---|---|---|---|---|---|
| D054058 | D004878 | Acute Coronary Syndrome |
marker/mechanism
|
16887217
|
|
| D020236 | D004878 | Amnesia, Transient Global |
marker/mechanism
|
15573308
|
|
| D000787 | D004878 | Angina Pectoris |
marker/mechanism
|
463911
7363818 |
|
| D000788 | D004878 | Angina Pectoris, Variant |
marker/mechanism
|
6786144
|
|
| D001157 | D004878 | Arterial Occlusive Diseases |
marker/mechanism
|
4423231
6852679 |
|
| D001929 | D004878 | Brain Edema |
marker/mechanism
|
2591142
|
|
| D020520 | D004878 | Brain Infarction |
marker/mechanism
|
2591142
3961460 |
|
| D002340 | D004878 | Carotid Artery Diseases |
marker/mechanism
|
1601926
|
|
| D002341 | D004878 | Carotid Artery Thrombosis |
marker/mechanism
|
6023455
|
|
| D002539 | D004878 | Cerebral Arterial Diseases |
marker/mechanism
|
6437683
|
|
| D002544 | D004878 | Cerebral Infarction |
marker/mechanism
|
16871899
|
|
| D002637 | D004878 | Chest Pain |
marker/mechanism
|
8162760
|
|
| D003027 | D004878 | Cluster Headache |
therapeutic
|
8559411
|
|
| D003324 | D004878 | Coronary Artery Disease |
marker/mechanism
|
9665056
|
|
| D003327 | D004878 | Coronary Disease |
marker/mechanism
|
809691
5015803 |
|
| D054059 | D004878 | Coronary Occlusion |
marker/mechanism
|
8299645
|
|
| D023921 | D004878 | Coronary Stenosis |
marker/mechanism
|
10409924
|
|
| D003328 | D004878 | Coronary Thrombosis |
marker/mechanism
|
4712163
|
|
| D003329 | D004878 | Coronary Vasospasm |
marker/mechanism
|
6786144
20159412 |
|
| D003680 | D004878 | Deglutition Disorders |
marker/mechanism
|
6807440
|
|
| D003967 | D004878 | Diarrhea |
marker/mechanism
|
15680136
|
|
| D004421 | D004878 | Dystonia |
marker/mechanism
|
1922133
|
|
| D004881 | D004878 | Ergotism |
marker/mechanism
|
403449
1601926 4408875 |
|
| D005130 | D004878 | Eye Hemorrhage |
marker/mechanism
|
1113911
|
|
| D005316 | D004878 | Fetal Distress |
marker/mechanism
|
8282144
|
|
| D005355 | D004878 | Fibrosis |
marker/mechanism
|
8436073
14978390 |
|
| D005734 | D004878 | Gangrene |
marker/mechanism
|
6108450
|
|
| D013700 | D004878 | Giant Cell Arteritis |
therapeutic
|
1474364
|
|
| D006261 | D004878 | Headache |
marker/mechanism
therapeutic |
625738
1767099 2241124 4827114 4852779 6786144 6807440 7159921 7828198 8104438 8314118 8397071 8559411 10442248 11037742 12463275 15613180 16643579 18671908 |
|
| D051270 | D004878 | Headache Disorders, Primary |
marker/mechanism
|
19085181
|
|
| D006331 | D004878 | Heart Diseases |
marker/mechanism
|
9818470
|
|
| D006349 | D004878 | Heart Valve Diseases |
marker/mechanism
|
2403780
8436073 9129909 9437392 10617681 11104741 12390688 15197703 15680136 19683643 |
|
| D006685 | D004878 | Hoarseness |
marker/mechanism
|
6807440
|
|
| D006732 | D004878 | Horner Syndrome |
marker/mechanism
|
6807440
|
|
| D006940 | D004878 | Hyperemia |
marker/mechanism
|
8197748
|
|
| D007024 | D004878 | Hypotension, Orthostatic |
therapeutic
|
14727996
|
|
| D007035 | D004878 | Hypothermia |
marker/mechanism
|
8314118
|
|
| D007238 | D004878 | Infarction |
marker/mechanism
|
11071983
|
|
| D007383 | D004878 | Intermittent Claudication |
marker/mechanism
|
10409924
|
|
| D020300 | D004878 | Intracranial Hemorrhages |
marker/mechanism
|
14606052
|
|
| D007511 | D004878 | Ischemia |
marker/mechanism
|
1081686
1601926 2936675 4375174 4792079 5479581 6236021 6807440 11887064 |
|
| D002546 | D004878 | Ischemic Attack, Transient |
marker/mechanism
|
16871899
|
|
| D001523 | D004878 | Mental Disorders |
marker/mechanism
|
11037742
|
|
| D008881 | D004878 | Migraine Disorders |
marker/mechanism
therapeutic |
463911
625457 866660 957964 1113911 1341823 1898754 1922133 2403780 4408875 4827114 6852679 8197748 8869763 9129909 10409924 10596308 11269787 15197703 15573308 15680136 16041395 16871899 16887217 |
|
| D009072 | D004878 | Moyamoya Disease |
marker/mechanism
|
16871899
|
|
| D054084 | D004878 | Myocardial Bridging |
marker/mechanism
|
16887217
|
|
| D009203 | D004878 | Myocardial Infarction |
marker/mechanism
|
3146787
6786144 6789432 6839985 7105868 |
|
| D017202 | D004878 | Myocardial Ischemia |
marker/mechanism
|
625457
7363818 |
|
| D009325 | D004878 | Nausea |
marker/mechanism
|
15680136
|
|
| D009395 | D004878 | Nephritis, Interstitial |
marker/mechanism
|
11071983
|
|
| D009896 | D004878 | Optic Atrophy |
marker/mechanism
|
732190
|
|
| D018917 | D004878 | Optic Neuropathy, Ischemic |
marker/mechanism
|
9759393
|
|
| D010167 | D004878 | Pallor |
marker/mechanism
|
8314118
|
|
| D010211 | D004878 | Papilledema |
marker/mechanism
|
732190
|
|
| D010292 | D004878 | Paresthesia |
marker/mechanism
|
6236021
8314118 |
|
| D010523 | D004878 | Peripheral Nervous System Diseases |
marker/mechanism
|
175101
|
|
| D016491 | D004878 | Peripheral Vascular Diseases |
marker/mechanism
|
271785
866660 4695411 7912993 |
|
| D012003 | D004878 | Rectal Fistula |
marker/mechanism
|
8197748
|
|
| D012021 | D004878 | Reflex, Abnormal |
marker/mechanism
|
6807440
|
|
| D012019 | D004878 | Reflex Sympathetic Dystrophy |
marker/mechanism
|
1922133
|
|
| D012640 | D004878 | Seizures |
marker/mechanism
|
18599194
|
|
| D020886 | D004878 | Somatosensory Disorders |
marker/mechanism
|
6807440
|
|
| D013035 | D004878 | Spasm |
marker/mechanism
|
1209209
4347498 4695411 4775957 4792079 5015803 6410215 |
|
| D019966 | D004878 | Substance-Related Disorders |
marker/mechanism
|
2591142
|
|
| D013375 | D004878 | Substance Withdrawal Syndrome |
marker/mechanism
|
3298163
4852779 7159921 15613180 |
|
| D013971 | D004878 | THYROTOXICOSIS |
marker/mechanism
|
16871899
|
|
| D014060 | D004878 | Tongue Diseases |
marker/mechanism
|
1474364
|
|
| D014652 | D004878 | Vascular Diseases |
marker/mechanism
|
1209209
2802263 4347498 |
|
| D020246 | D004878 | VENOUS THROMBOSIS |
marker/mechanism
|
4449779
|
|
| D014693 | D004878 | Ventricular Fibrillation |
marker/mechanism
|
8299645
10596308 |
|
| D014717 | D004878 | Vertigo |
marker/mechanism
|
6807440
|
|
| D014839 | D004878 | Vomiting |
marker/mechanism
|
10431323
15680136 |
|
| D014987 | D004878 | Xerostomia |
marker/mechanism
|
15680136
|