Species

KNApSAcK Entry

Organism name Claviceps paspali
Genus Claviceps
Family Clavicipitaceae
Kingdom Fungi

NCBI taxonomy

Entry

Linked NCBI taxonomy name Claviceps paspali
Linked NCBI taxonomy ID 40601
Linked level species

Family

Family in NCBI taxonomy Clavicipitaceae
ID 34397

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Fungi
ID 4751

Plant class

Plant class
ID

Metabolite list (6)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00001724 External link 512 Ergotamine
CHEMBL442
CHEMBL1315610
CHEMBL1402957
CHEMBL1982133
D004878
116 / 57 / 51 2 / 73 No. 271 No. 4
C00011202 External link 512 8-Hydroxyergine
No. 657 No. 4
C00011204 External link 512 8-Hydroxyerginine
No. 657 No. 4
C00023579 External link 512 Paspaline
C048221
No. 819
C00023580 External link 512 Paspalicine
C048222
No. 1358
C00023581 External link 512 Paspalinine
C048223
No. 1358

Human Protein / Gene in interactions

116 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00001724 1 / 0
P21728 D(1A) dopamine receptor Dopamine receptor C00001724 0 / 0
P27338 Amine oxidase [flavin-containing] B Oxidoreductase C00001724 0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00001724 0 / 3
Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH, Kv10-12.x (Ether-a-go-go) C00001724 2 / 2
P08246 Neutrophil elastase S1A C00001724 2 / 1
P33765 Adenosine receptor A3 Adenosine receptor C00001724 0 / 0
Q16539 Mitogen-activated protein kinase 14 p38 C00001724 0 / 0
P49146 Neuropeptide Y receptor type 2 Neuropeptide Y receptor C00001724 0 / 0
P29466 Caspase-1 C14 C00001724 0 / 0
P17252 Protein kinase C alpha type Alpha C00001724 0 / 0
P27361 Mitogen-activated protein kinase 3 Erk C00001724 0 / 0
P14780 Matrix metalloproteinase-9 M10A C00001724 2 / 2
O15245 Solute carrier family 22 member 1 Drug uniporter C00001724 0 / 0
P10828 Thyroid hormone receptor beta NR1A2 C00001724 3 / 1
P00918 Carbonic anhydrase 2 Lyase C00001724 1 / 2
P07550 Beta-2 adrenergic receptor Adrenergic receptor C00001724 0 / 1
P21397 Amine oxidase [flavin-containing] A Oxidoreductase C00001724 1 / 1
P25021 Histamine H2 receptor Histamine receptor C00001724 0 / 0
P28222 5-hydroxytryptamine receptor 1B Serotonin receptor C00001724 0 / 0
P35367 Histamine H1 receptor Histamine receptor C00001724 0 / 0
Q01959 Sodium-dependent dopamine transporter Dopamine C00001724 1 / 0
P08912 Muscarinic acetylcholine receptor M5 Acetylcholine receptor C00001724 0 / 0
P18825 Alpha-2C adrenergic receptor Adrenergic receptor C00001724 0 / 0
P13945 Beta-3 adrenergic receptor Adrenergic receptor C00001724 0 / 0
P47898 5-hydroxytryptamine receptor 5A Serotonin receptor C00001724 0 / 0
P08183 Multidrug resistance protein 1 drug C00001724 1 / 0
P25024 C-X-C chemokine receptor type 1 CXC chemokine receptor C00001724 0 / 0
P06241 Tyrosine-protein kinase Fyn Src C00001724 0 / 0
Q08209 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform Ser_Thr C00001724 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00001724 0 / 1
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily C00001724 1 / 8
P11473 Vitamin D3 receptor NR1I1 C00001724 2 / 3
P14416 D(2) dopamine receptor Dopamine receptor C00001724 2 / 0
P23219 Prostaglandin G/H synthase 1 Oxidoreductase C00001724 0 / 0
P37288 Vasopressin V1a receptor Vasopressin and oxytocin receptor C00001724 0 / 0
P41145 Kappa-type opioid receptor Opioid receptor C00001724 0 / 0
Q9Y271 Cysteinyl leukotriene receptor 1 Leukotriene receptor C00001724 0 / 0
P29274 Adenosine receptor A2a Adenosine receptor C00001724 0 / 0
P25929 Neuropeptide Y receptor type 1 Neuropeptide Y receptor C00001724 0 / 0
P50052 Type-2 angiotensin II receptor Angiotensin receptor C00001724 1 / 1
P17948 Vascular endothelial growth factor receptor 1 Vegfr C00001724 0 / 0
P41968 Melanocortin receptor 3 Melanocortin receptor C00001724 1 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00001724 0 / 0
P11509 Cytochrome P450 2A6 Cytochrome P450 2A6 C00001724 0 / 0
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor C00001724 0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme C00001724 0 / 0
P38398 Breast cancer type 1 susceptibility protein Enzyme C00001724 4 / 2
P04035 3-hydroxy-3-methylglutaryl-coenzyme A reductase Oxidoreductase C00001724 0 / 0
P08913 Alpha-2A adrenergic receptor Adrenergic receptor C00001724 0 / 0
P21917 D(4) dopamine receptor Dopamine receptor C00001724 0 / 0
P30988 Calcitonin receptor Calcitonin receptor C00001724 0 / 0
P35462 D(3) dopamine receptor Dopamine receptor C00001724 1 / 0
P41143 Delta-type opioid receptor Opioid receptor C00001724 0 / 0
Q92731 Estrogen receptor beta NR3A2 C00001724 0 / 1
P41595 5-hydroxytryptamine receptor 2B Serotonin receptor C00001724 0 / 0
P25101 Endothelin-1 receptor Endothelin receptor C00001724 0 / 0
P30411 B2 bradykinin receptor Bradykinin receptor C00001724 0 / 0
P32245 Melanocortin receptor 4 Melanocortin receptor C00001724 1 / 0
P32238 Cholecystokinin receptor type A Cholecystokinin receptor C00001724 0 / 0
P08311 Cathepsin G S1A C00001724 0 / 0
Q99720 Sigma non-opioid intracellular receptor 1 Membrane receptor C00001724 1 / 0
P03956 Interstitial collagenase M10A C00001724 0 / 1
P32241 Vasoactive intestinal polypeptide receptor 1 Vasoactive intestinal peptide receptor C00001724 0 / 0
Q9HC16 DNA dC->dU-editing enzyme APOBEC-3G Enzyme C00001724 0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00001724 0 / 0
P04150 Glucocorticoid receptor NR3C1 C00001724 0 / 1
P08172 Muscarinic acetylcholine receptor M2 Acetylcholine receptor C00001724 2 / 0
P11229 Muscarinic acetylcholine receptor M1 Acetylcholine receptor C00001724 0 / 0
P21554 Cannabinoid receptor 1 Cannabinoid receptor C00001724 0 / 0
P31645 Sodium-dependent serotonin transporter Serotonin C00001724 2 / 0
P04626 Receptor tyrosine-protein kinase erbB-2 TK tyrosine-protein kinase EGFR subfamily C00001724 5 / 9
P20309 Muscarinic acetylcholine receptor M3 Acetylcholine receptor C00001724 1 / 0
P21452 Substance-K receptor Neurokinin receptor C00001724 0 / 0
P51679 C-C chemokine receptor type 4 CC chemokine receptor C00001724 0 / 0
P51681 C-C chemokine receptor type 5 CC chemokine receptor C00001724 3 / 0
P50406 5-hydroxytryptamine receptor 6 Serotonin receptor C00001724 0 / 0
P41597 C-C chemokine receptor type 2 CC chemokine receptor C00001724 1 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00001724 0 / 0
P08575 Receptor-type tyrosine-protein phosphatase C Enzyme C00001724 2 / 1
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00001724 0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00001724 3 / 3
O76074 cGMP-specific 3',5'-cyclic phosphodiesterase PDE_5A C00001724 0 / 0
P03372 Estrogen receptor NR3A1 C00001724 1 / 1
P08588 Beta-1 adrenergic receptor Adrenergic receptor C00001724 1 / 0
P22303 Acetylcholinesterase Hydrolase C00001724 1 / 0
P28223 5-hydroxytryptamine receptor 2A Serotonin receptor C00001724 0 / 0
P28335 5-hydroxytryptamine receptor 2C Serotonin receptor C00001724 0 / 0
P35372 Mu-type opioid receptor Opioid receptor C00001724 0 / 0
P08173 Muscarinic acetylcholine receptor M4 Acetylcholine receptor C00001724 0 / 0
P25103 Substance-P receptor Neurokinin receptor C00001724 0 / 0
P25105 Platelet-activating factor receptor PAF receptor C00001724 0 / 0
P33032 Melanocortin receptor 5 Melanocortin receptor C00001724 0 / 0
P55210 Caspase-7 C14 C00001724 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00001724 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00001724 0 / 1
P05181 Cytochrome P450 2E1 Cytochrome P450 2E1 C00001724 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00001724 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00001724 4 / 3
P23975 Sodium-dependent noradrenaline transporter Norepinephrine C00001724 1 / 1
P25100 Alpha-1D adrenergic receptor Adrenergic receptor C00001724 0 / 0
P28221 5-hydroxytryptamine receptor 1D Serotonin receptor C00001724 0 / 0
P30542 Adenosine receptor A1 Adenosine receptor C00001724 0 / 0
P18089 Alpha-2B adrenergic receptor Adrenergic receptor C00001724 0 / 0
P24557 Thromboxane-A synthase Cytochrome P450 5A1 C00001724 1 / 1
P06239 Tyrosine-protein kinase Lck Src C00001724 0 / 1
P25025 C-X-C chemokine receptor type 2 CXC chemokine receptor C00001724 0 / 0
Q9UBT6 DNA polymerase kappa Enzyme C00001724 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00001724 0 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme C00001724 0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00001724 1 / 1
O00255 Menin Unclassified protein C00001724 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00001724 1 / 2
Q13951 Core-binding factor subunit beta Unclassified protein C00001724 0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein C00001724 1 / 4
Q8N6T7 NAD-dependent protein deacetylase sirtuin-6 Enzyme C00001724 0 / 0

2 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
836 CASP3, CPP32, CPP32B, SCA-1 caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) C00001724
3357 HTR2B, 5-HT(2B), 5-HT2B 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled C00001724

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (57)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#100100 Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism P20309
#103780 Alcohol dependence P08172
P14416
P31645
#614373 Amyotrophic lateral sclerosis 16, juvenile; als16 Q99720
#602025 Body mass index quantitative trait locus 9; bmiq9 P41968
#114480 Breast cancer P38398
#604370 Breast-ovarian cancer, familial, susceptibility to, 1; brovca1 P38398
#300615 Brunner syndrome P21397
#162800 Cyclic neutropenia P08246
#612522 Diabetes mellitus, insulin-dependent, 22; iddm22 P51681
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#615363 Estrogen resistance; estrr P03372
#600274 Frontotemporal dementia; ftd P10636
#613659 Gastric cancer P04626
#137215 Gastric cancer, hereditary diffuse; hdgc P04626
#231095 Ghosal hematodiaphyseal dysplasia; ghdd P24557
#137800 Glioma susceptibility 1; glm1 P04626
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#609423 Human immunodeficiency virus type 1, susceptibility to P41597
P51681
#145000 Hyperparathyroidism 1; hrpt1 O00255
#612244 Inflammatory bowel disease 13; ibd13 P08183
#603932 Intervertebral disc disease; idd P14780
#613688 Long qt syndrome 2; lqt2 Q12809
#211980 Lung cancer P00533
P04626
#608516 Major depressive disorder; mdd P08172
#300705 Mental retardation, x-linked 17; mrx17 Q99714
%300852 Mental retardation, x-linked 88; mrx88 P50052
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#126200 Multiple sclerosis, susceptibility to; ms P08575
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#159900 Myoclonic dystonia P14416
#202700 Neutropenia, severe congenital, 1, autosomal dominant; scn1 P08246
#601665 Obesity P32245
#164230 Obsessive-compulsive disorder; ocd P31645
#604715 Orthostatic intolerance P23975
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#167000 Ovarian cancer P04626
P38398
#614320 Pancreatic cancer, susceptibility to, 4; pnca4 P38398
#260540 Parkinson-dementia syndrome P10636
#613135 Parkinsonism-dystonia, infantile; pkdys Q01959
#172700 Pick disease of brain P10636
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#607276 Resting heart rate, variation in P08588
#608971 Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive P08575
#609620 Short qt syndrome 1; sqt1 Q12809
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828
#190300 Tremor, hereditary essential, 1; etm1 P35462
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473
#610379 West nile virus, susceptibility to P51681
#112100 Yt blood group antigen P22303

KEGG DISEASE (51)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00016 Oral cancer P00533 (related)
P00533 (marker)
H00017 Esophageal cancer P00533 (related)
P35354 (related)
H00018 Gastric cancer P00533 (related)
P04626 (related)
H00022 Bladder cancer P00533 (related)
P04626 (related)
H00028 Choriocarcinoma P00533 (related)
P03956 (related)
P04626 (related)
H00030 Cervical cancer P00533 (related)
P04626 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00026 Endometrial Cancer P03372 (marker)
P04626 (related)
Q92731 (marker)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00019 Pancreatic cancer P04626 (related)
H00027 Ovarian cancer P04626 (related)
P38398 (related)
H00031 Breast cancer P04626 (related)
P04626 (marker)
P38398 (related)
H00046 Cholangiocarcinoma P04626 (related)
P35354 (related)
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
H00079 Asthma P07550 (related)
H00100 Neutropenic disorders P08246 (related)
H00091 T-B+Severe combined immunodeficiencies (SCIDs) P08575 (related)
H00036 Osteosarcoma P08684 (marker)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H01205 Coumarin resistance P11712 (related)
H00025 Penile cancer P14780 (related)
P35354 (related)
H00479 Metaphyseal dysplasias P14780 (related)
H00548 Brunner syndrome P21397 (related)
H01031 Orthostatic intolerance (OI) P23975 (related)
H00490 Diaphyseal dysplasia with anemia (Ghosal) P24557 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00480 Non-syndromic X-linked mental retardation P50052 (related)
Q99714 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00720 Long QT syndrome Q12809 (related)
H00725 Short QT syndrome Q12809 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H00063 Spinocerebellar ataxia (SCA) Q9NUW8 (related)

Diseases related to CTD interactions

73 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D054058 Acute Coronary Syndrome C00001724
D020236 Amnesia, Transient Global C00001724
D000787 Angina Pectoris C00001724
D000788 Angina Pectoris, Variant C00001724
D001157 Arterial Occlusive Diseases C00001724
D001929 Brain Edema C00001724
D020520 Brain Infarction C00001724
D002340 Carotid Artery Diseases C00001724
D002341 Carotid Artery Thrombosis C00001724
D002539 Cerebral Arterial Diseases C00001724
D002544 Cerebral Infarction C00001724
D002637 Chest Pain C00001724
D003027 Cluster Headache C00001724
D003324 Coronary Artery Disease C00001724
D003327 Coronary Disease C00001724
D054059 Coronary Occlusion C00001724
D023921 Coronary Stenosis C00001724
D003328 Coronary Thrombosis C00001724
D003329 Coronary Vasospasm C00001724
D003680 Deglutition Disorders C00001724
D003967 Diarrhea C00001724
D004421 Dystonia C00001724
D004881 Ergotism C00001724
D005130 Eye Hemorrhage C00001724
D005316 Fetal Distress C00001724
D005355 Fibrosis C00001724
D005734 Gangrene C00001724
D013700 Giant Cell Arteritis C00001724
D006261 Headache C00001724
D051270 Headache Disorders, Primary C00001724
D006331 Heart Diseases C00001724
D006349 Heart Valve Diseases C00001724
D006685 Hoarseness C00001724
D006732 Horner Syndrome C00001724
D006940 Hyperemia C00001724
D007024 Hypotension, Orthostatic C00001724
D007035 Hypothermia C00001724
D007238 Infarction C00001724
D007383 Intermittent Claudication C00001724
D020300 Intracranial Hemorrhages C00001724
D007511 Ischemia C00001724
D002546 Ischemic Attack, Transient C00001724
D001523 Mental Disorders C00001724
D008881 Migraine Disorders C00001724
D009072 Moyamoya Disease C00001724
D054084 Myocardial Bridging C00001724
D009203 Myocardial Infarction C00001724
D017202 Myocardial Ischemia C00001724
D009325 Nausea C00001724
D009395 Nephritis, Interstitial C00001724
D009896 Optic Atrophy C00001724
D018917 Optic Neuropathy, Ischemic C00001724
D010167 Pallor C00001724
D010211 Papilledema C00001724
D010292 Paresthesia C00001724
D010523 Peripheral Nervous System Diseases C00001724
D016491 Peripheral Vascular Diseases C00001724
D012003 Rectal Fistula C00001724
D012021 Reflex, Abnormal C00001724
D012019 Reflex Sympathetic Dystrophy C00001724
D012640 Seizures C00001724
D020886 Somatosensory Disorders C00001724
D013035 Spasm C00001724
D019966 Substance-Related Disorders C00001724
D013375 Substance Withdrawal Syndrome C00001724
D013971 THYROTOXICOSIS C00001724
D014060 Tongue Diseases C00001724
D014652 Vascular Diseases C00001724
D020246 VENOUS THROMBOSIS C00001724
D014693 Ventricular Fibrillation C00001724
D014717 Vertigo C00001724
D014839 Vomiting C00001724
D014987 Xerostomia C00001724