KNApSAcK Metabolite C00017521
Metabolite
KNApSAcK Entry
| id | C00017521 |
|---|---|
| Name | Qing Hau acid / Artemisic acid / Arteannuic acid / Artemisinic acid / Artemisininic acid |
| CAS RN | 80286-58-4 |
| Standard InChI | InChI=1S/C15H22O2/c1-9-4-6-12-10(2)5-7-13(14(12)8-9)11(3)15(16)17/h8,10,12-14H,3-7H2,1-2H3,(H,16,17)/t10-,12+,13+,14+/m1/s1 |
| Standard InChI (Main Layer) | InChI=1S/C15H22O2/c1-9-4-6-12-10(2)5-7-13(14(12)8-9)11(3)15(16)17/h8,10,12-14H,3-7H2,1-2H3,(H,16,17) |
Cluster
| Phytochemical cluster | No. 38 |
|---|---|
| KCF-S cluster | No. 834 |
Link
ChEMBL
| By standard InChI | CHEMBL457385 |
|---|---|
| By standard InChI Main Layer | CHEMBL457385 |
KEGG
| By LinkDB |
|---|
CTD
| By CAS RN | C047721 |
|---|
Species
Summary
Plant class
| class name | count |
|---|---|
| asterids | 1 |
Family
| family name | count |
|---|---|
| Asteraceae | 1 |
List (1)
* NCBI
| KNApSAcK organism | *ID | *family | *plant class | *kingdom |
|---|---|---|---|---|
| Artemisia annua | 35608 | Asteraceae | asterids | Viridiplantae |
Human Protein / Gene in interaction
CTD interaction (15)
| compound | gene | gene name | gene description | interaction | interaction type | form |
reference
pmid |
|---|---|---|---|---|---|---|---|
| C047721 | 1050 |
CEBPA
C/EBP-alpha CEBP |
CCAAT/enhancer binding protein (C/EBP), alpha | artemisic acid results in decreased expression of CEBPA mRNA |
decreases expression
|
mRNA |
23063590
|
| C047721 | 1050 |
CEBPA
C/EBP-alpha CEBP |
CCAAT/enhancer binding protein (C/EBP), alpha | [artemisic acid results in decreased expression of CEBPA mRNA] which results in decreased expression of HMGCR mRNA |
decreases expression
|
mRNA |
23063590
|
| C047721 | 1050 |
CEBPA
C/EBP-alpha CEBP |
CCAAT/enhancer binding protein (C/EBP), alpha | [[artemisic acid results in decreased expression of CEBPA mRNA] which results in decreased expression of HMGCR mRNA] which results in decreased chemical synthesis of Cholesterol |
decreases chemical synthesis
/ decreases expression |
mRNA |
23063590
|
| C047721 | 1638 |
DCT
TRP-2 TYRP2 |
dopachrome tautomerase (EC:5.3.3.12) | artemisic acid results in decreased expression of DCT mRNA |
decreases expression
|
mRNA |
23063590
|
| C047721 | 3156 |
HMGCR
LDLCQ3 |
3-hydroxy-3-methylglutaryl-CoA reductase (EC:1.1.1.34) | [artemisic acid results in decreased expression of CEBPA mRNA] which results in decreased expression of HMGCR mRNA |
decreases expression
|
mRNA |
23063590
|
| C047721 | 3156 |
HMGCR
LDLCQ3 |
3-hydroxy-3-methylglutaryl-CoA reductase (EC:1.1.1.34) | [[artemisic acid results in decreased expression of CEBPA mRNA] which results in decreased expression of HMGCR mRNA] which results in decreased chemical synthesis of Cholesterol |
decreases chemical synthesis
/ decreases expression |
mRNA |
23063590
|
| C047721 | 3156 |
HMGCR
LDLCQ3 |
3-hydroxy-3-methylglutaryl-CoA reductase (EC:1.1.1.34) | artemisic acid results in decreased expression of HMGCR mRNA |
decreases expression
|
mRNA |
23063590
|
| C047721 | 3156 |
HMGCR
LDLCQ3 |
3-hydroxy-3-methylglutaryl-CoA reductase (EC:1.1.1.34) | artemisic acid results in decreased expression of HMGCR protein |
decreases expression
|
protein |
23063590
|
| C047721 | 3156 |
HMGCR
LDLCQ3 |
3-hydroxy-3-methylglutaryl-CoA reductase (EC:1.1.1.34) | [artemisic acid results in decreased expression of HMGCR protein] which results in decreased chemical synthesis of Cholesterol |
decreases chemical synthesis
/ decreases expression |
protein |
23063590
|
| C047721 | 3815 |
KIT
C-Kit CD117 PBT SCFR |
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog (EC:2.7.10.1) | artemisic acid results in decreased expression of KIT mRNA |
decreases expression
|
mRNA |
23063590
|
| C047721 | 4254 |
KITLG
FPH2 KL-1 Kitl MGF SCF SF SHEP7 |
KIT ligand | artemisic acid results in decreased expression of KITLG mRNA |
decreases expression
|
mRNA |
23063590
|
| C047721 | 4282 |
MIF
GIF GLIF MMIF |
macrophage migration inhibitory factor (glycosylation-inhibiting factor) (EC:5.3.3.12 5.3.2.1) | artemisic acid results in decreased expression of MIF mRNA |
decreases expression
|
mRNA |
23063590
|
| C047721 | 4286 |
MITF
CMM8 MI WS2 WS2A bHLHe32 |
microphthalmia-associated transcription factor | artemisic acid results in decreased expression of MITF mRNA |
decreases expression
|
mRNA |
23063590
|
| C047721 | 7299 |
TYR
ATN CMM8 OCA1 OCA1A OCAIA SHEP3 |
tyrosinase (EC:1.14.18.1) | artemisic acid results in decreased expression of TYR mRNA |
decreases expression
|
mRNA |
23063590
|
| C047721 | 7306 |
TYRP1
CAS2 CATB GP75 OCA3 TRP TRP1 TYRP b-PROTEIN |
tyrosinase-related protein 1 (EC:1.14.18.-) | artemisic acid results in decreased expression of TYRP1 mRNA |
decreases expression
|
mRNA |
23063590
|