PCIDB

KNApSAcK Metabolite C00017631

Metabolite

KNApSAcK Entry

id C00017631
Name FR 520 / FK 520 / L 683590 / Ascomycin / FR 900520 / Immunomycin / Changchuanmycin
CAS RN 104987-12-4
Standard InChI InChI=1S/C43H69NO12/c1-10-30-18-24(2)17-25(3)19-36(53-8)39-37(54-9)21-27(5)43(51,56-39)40(48)41(49)44-16-12-11-13-31(44)42(50)55-38(28(6)33(46)23-34(30)47)26(4)20-29-14-15-32(45)35(22-29)52-7/h18,20,25,27-33,35-39,45-46,51H,10-17,19,21-23H2,1-9H3/b24-18-,26-20+/t25-,27+,28+,29-,30+,31-,32+,33-,35+,36-,37-,38?,39+,43+/m0/s1
Standard InChI (Main Layer) InChI=1S/C43H69NO12/c1-10-30-18-24(2)17-25(3)19-36(53-8)39-37(54-9)21-27(5)43(51,56-39)40(48)41(49)44-16-12-11-13-31(44)42(50)55-38(28(6)33(46)23-34(30)47)26(4)20-29-14-15-32(45)35(22-29)52-7/h18,20,25,27-33,35-39,45-46,51H,10-17,19,21-23H2,1-9H3

Cluster

Phytochemical cluster
KCF-S cluster No. 2347

Link

ChEMBL

By standard InChI
By standard InChI Main Layer CHEMBL8597 CHEMBL1363310

KEGG

By LinkDB C12102

CTD

By CAS RN C058028

Species

Summary

Plant class

class name count

Family

family name count
Streptomycetaceae 2

List (2)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Streptomyces KK317 1883 Streptomycetaceae Bacteria
Streptomyces hygroscopicus subsp. yakushimaensis subsp. nov. 1883 Streptomycetaceae Bacteria

Human Protein / Gene in interaction

12 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P49798 Regulator of G-protein signaling 4 Unclassified protein CHEMBL8597 CHEMBL1794499 (1)
2 / 0
P02545 Prelamin-A/C Unclassified protein CHEMBL1363310 CHEMBL1614544 (1)
11 / 10
P10828 Thyroid hormone receptor beta NR1A2 CHEMBL8597 CHEMBL1613776 (1)
3 / 1
Q02790 Peptidyl-prolyl cis-trans isomerase FKBP4 Enzyme CHEMBL8597 CHEMBL843423 (1)
0 / 0
O75496 Geminin Unclassified protein CHEMBL1363310 CHEMBL2114843 (1) CHEMBL2114780 (1)
0 / 0
Q03164 Histone-lysine N-methyltransferase 2A Enzyme CHEMBL1363310 CHEMBL1614257 (1) CHEMBL1614410 (1)
1 / 3
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein CHEMBL1363310 CHEMBL1738588 (1)
0 / 0
P62942 Peptidyl-prolyl cis-trans isomerase FKBP1A Isomerase CHEMBL8597 CHEMBL682212 (1) CHEMBL678141 (1)
CHEMBL678142 (1) CHEMBL678147 (1)
CHEMBL678148 (1) CHEMBL678150 (1)
CHEMBL678151 (1) CHEMBL678154 (1)
0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme CHEMBL8597 CHEMBL1614211 (1)
0 / 0
P10636 Microtubule-associated protein tau Unclassified protein CHEMBL1363310 CHEMBL1614421 (1)
4 / 3
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme CHEMBL8597 CHEMBL1363310 CHEMBL1738442 (2)
0 / 0
O00255 Menin Unclassified protein CHEMBL1363310 CHEMBL1614257 (1)
2 / 5

CTD interaction (1)

compound gene gene name gene description interaction interaction type form reference
pmid
C058028 4137 MAPT
DDPAC
FTDP-17
MAPTL
MSTD
MTBT1
MTBT2
PPND
TAU
microtubule-associated protein tau [Okadaic Acid co-treated with immunomycin] results in increased phosphorylation of MAPT protein affects cotreatment
/ increases phosphorylation
protein 7723735

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (23)

OMIM preferred title UniProt
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#600274 Frontotemporal dementia; ftd P10636
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#145000 Hyperparathyroidism 1; hrpt1 O00255
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#275210 Restrictive dermopathy, lethal P02545
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828

KEGG DISEASE (21)

KEGG disease name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)

Diseases related to CTD interactions

3 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D007035 C058028 Hypothermia marker/mechanism
10450987
D007674 C058028 Kidney Diseases marker/mechanism
9570331
10450987
D012640 C058028 Seizures therapeutic
16872668