PCIDB

KCF-S cluster No. 2347 (5 metabolites)

Plant Species

Cumulative plant class count

class name count

Cumulative family count

class name count
Streptomycetaceae 6

KEGG BRITE br08003 External link 512

Categories (0)

br08003 Category # of metabolite

metabolites link (0)

br08003 Category KEGG ID KNApSAcK ID

Metabolite list (5)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		figure
C00015929 External link 512 16-O-Desmethyl-27-desmethoxyrapamycin
C00017631 External link 512 FR 520
/ FK 520
/ L 683590
/ Ascomycin
/ FR 900520
/ Immunomycin
/ Changchuanmycin
CHEMBL8597
CHEMBL1363310
C058028
12 / 23 / 21 1 / 3
C00017632 External link 512 FR 900523
CHEMBL351445
C058030
C00017673 External link 512 FK 525
/ FR 900525
C059958
C00018055 External link 512 Rapamycin
CHEMBL413
CHEMBL295272
CHEMBL1328768
CHEMBL1329171
CHEMBL1446796
CHEMBL1473145
CHEMBL1706754
CHEMBL1988195
D020123
349 / 161 / 99 224 / 108

Human Protein / Gene in interactions

356 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
O75496 Geminin Unclassified protein C00017631 C00018055 0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00017631 C00018055 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00017631 C00018055 4 / 3
P62942 Peptidyl-prolyl cis-trans isomerase FKBP1A Isomerase C00017631 C00018055 0 / 0
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00017631 C00018055 0 / 0
P35557 Glucokinase Enzyme C00018055 3 / 3
P42685 Tyrosine-protein kinase FRK Src C00018055 0 / 0
Q13043 Serine/threonine-protein kinase 4 STE serine/threonine protein kinase MST subfamily C00018055 1 / 0
Q9P1W9 Serine/threonine-protein kinase pim-2 Pim C00018055 0 / 0
Q8TDX7 Serine/threonine-protein kinase Nek7 Nek C00018055 0 / 0
Q5VT25 Serine/threonine-protein kinase MRCK alpha AGC serine/threonine protein kinase GEK subfamily C00018055 0 / 0
Q14289 Protein-tyrosine kinase 2-beta Fak C00018055 0 / 0
P08922 Proto-oncogene tyrosine-protein kinase ROS TK tyrosine-protein kinase SEV C00018055 0 / 1
Q15831 Serine/threonine-protein kinase STK11 Lkb C00018055 2 / 2
Q9Y6L6 Solute carrier organic anion transporter family member 1B1 Electrochemical transporter C00018055 1 / 0
P49798 Regulator of G-protein signaling 4 Unclassified protein C00017631 2 / 0
Q9BYP7 Serine/threonine-protein kinase WNK3 WNK serine/threonine protein kinase subfamily C00018055 0 / 0
P21728 D(1A) dopamine receptor Dopamine receptor C00018055 0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00018055 0 / 3
Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH, Kv10-12.x (Ether-a-go-go) C00018055 2 / 2
P08069 Insulin-like growth factor 1 receptor TK tyrosine-protein kinase INSR subfamily C00018055 1 / 3
P08246 Neutrophil elastase S1A C00018055 2 / 1
P33765 Adenosine receptor A3 Adenosine receptor C00018055 0 / 0
Q15759 Mitogen-activated protein kinase 11 p38 C00018055 0 / 0
Q16539 Mitogen-activated protein kinase 14 p38 C00018055 0 / 0
P21802 Fibroblast growth factor receptor 2 TK tyrosine-protein kinase TLK subfamily C00018055 9 / 3
P49146 Neuropeptide Y receptor type 2 Neuropeptide Y receptor C00018055 0 / 0
O15530 3-phosphoinositide-dependent protein kinase 1 Pdk1 C00018055 0 / 0
Q9UIK4 Death-associated protein kinase 2 Dapk C00018055 0 / 0
P41240 Tyrosine-protein kinase CSK Csk C00018055 0 / 0
P45984 Mitogen-activated protein kinase 9 Jnk C00018055 0 / 0
P29466 Caspase-1 C14 C00018055 0 / 0
P17252 Protein kinase C alpha type Alpha C00018055 0 / 0
P27361 Mitogen-activated protein kinase 3 Erk C00018055 0 / 0
Q15349 Ribosomal protein S6 kinase alpha-2 Rskb C00018055 0 / 0
P04629 High affinity nerve growth factor receptor Trk C00018055 2 / 3
Q05655 Protein kinase C delta type Delta C00018055 0 / 0
P14780 Matrix metalloproteinase-9 M10A C00018055 2 / 2
Q04759 Protein kinase C theta type Delta C00018055 0 / 1
Q15303 Receptor tyrosine-protein kinase erbB-4 TK tyrosine-protein kinase EGFR subfamily C00018055 0 / 0
O14757 Serine/threonine-protein kinase Chk1 Chk1 C00018055 0 / 0
O14965 Aurora kinase A Aur C00018055 0 / 0
Q7KZI7 Serine/threonine-protein kinase MARK2 CAMK serine/threonine protein kinase MARK subfamily C00018055 0 / 0
Q13882 Protein-tyrosine kinase 6 Src C00018055 0 / 0
Q8IWQ3 Serine/threonine-protein kinase BRSK2 CAMK serine/threonine protein kinase BRSK subfamily C00018055 0 / 0
P27448 MAP/microtubule affinity-regulating kinase 3 CAMK serine/threonine protein kinase MARK subfamily C00018055 0 / 0
Q9UHD2 Serine/threonine-protein kinase TBK1 Ikk C00018055 1 / 0
P21709 Ephrin type-A receptor 1 Eph C00018055 0 / 0
Q9P0L2 Serine/threonine-protein kinase MARK1 CAMK serine/threonine protein kinase MARK subfamily C00018055 0 / 0
P02545 Prelamin-A/C Unclassified protein C00017631 11 / 10
Q96PF2 Testis-specific serine/threonine-protein kinase 2 CAMK serine/threonine protein kinase TSSK subfamily C00018055 0 / 0
P51956 Serine/threonine-protein kinase Nek3 Nek1 C00018055 0 / 0
P37840 Alpha-synuclein Unclassified protein C00018055 4 / 2
P00519 Tyrosine-protein kinase ABL1 Abl C00018055 1 / 2
P10828 Thyroid hormone receptor beta NR1A2 C00017631 3 / 1
P00918 Carbonic anhydrase 2 Lyase C00018055 1 / 2
P07550 Beta-2 adrenergic receptor Adrenergic receptor C00018055 0 / 1
P21397 Amine oxidase [flavin-containing] A Oxidoreductase C00018055 1 / 1
P25021 Histamine H2 receptor Histamine receptor C00018055 0 / 0
P35367 Histamine H1 receptor Histamine receptor C00018055 0 / 0
Q01959 Sodium-dependent dopamine transporter Dopamine C00018055 1 / 0
P08912 Muscarinic acetylcholine receptor M5 Acetylcholine receptor C00018055 0 / 0
P18825 Alpha-2C adrenergic receptor Adrenergic receptor C00018055 0 / 0
P13945 Beta-3 adrenergic receptor Adrenergic receptor C00018055 0 / 0
Q05513 Protein kinase C zeta type Iota C00018055 0 / 0
P11309 Serine/threonine-protein kinase pim-1 Pim C00018055 0 / 0
Q02156 Protein kinase C epsilon type Eta C00018055 0 / 0
P41743 Protein kinase C iota type Iota C00018055 0 / 0
Q9UK32 Ribosomal protein S6 kinase alpha-6 Rskb C00018055 0 / 0
Q04912 Macrophage-stimulating protein receptor TK tyrosine-protein kinase MET subfamily C00018055 0 / 0
P08183 Multidrug resistance protein 1 drug C00018055 1 / 0
P25024 C-X-C chemokine receptor type 1 CXC chemokine receptor C00018055 0 / 0
Q13557 Calcium/calmodulin-dependent protein kinase type II subunit delta Camk2 C00018055 0 / 0
P06241 Tyrosine-protein kinase Fyn Src C00018055 0 / 0
P80192 Mitogen-activated protein kinase kinase kinase 9 TKL dual-specificity kinase MLK C00018055 0 / 0
P43403 Tyrosine-protein kinase ZAP-70 Syk C00018055 1 / 2
Q08209 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform Ser_Thr C00018055 0 / 0
P16234 Platelet-derived growth factor receptor alpha Pdgfr C00018055 2 / 1
P19784 Casein kinase II subunit alpha' Ck2 C00018055 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00018055 0 / 1
P23443 Ribosomal protein S6 kinase beta-1 p70 C00018055 0 / 0
Q9UQB9 Aurora kinase C Aur C00018055 1 / 1
P49761 Dual specificity protein kinase CLK3 Clk C00018055 0 / 0
P51813 Cytoplasmic tyrosine-protein kinase BMX Tec C00018055 0 / 0
Q9HBH9 MAP kinase-interacting serine/threonine-protein kinase 2 CAMK serine/threonine protein kinase MNK subfamily C00018055 0 / 0
Q9NQU5 Serine/threonine-protein kinase PAK 6 STE serine/threonine protein kinase PAKB subfamily C00018055 0 / 0
Q16644 MAP kinase-activated protein kinase 3 CAMK serine/threonine protein kinase MAPKAPK C00018055 0 / 0
Q06187 Tyrosine-protein kinase BTK Tec C00018055 2 / 2
Q9H422 Homeodomain-interacting protein kinase 3 CMGC dual-specificity kinase HIPK C00018055 0 / 0
Q14680 Maternal embryonic leucine zipper kinase Melk C00018055 0 / 0
Q9UBE8 Serine/threonine-protein kinase NLK CMGC serine/threonine protein kinase NMO subfamily C00018055 0 / 0
Q12866 Tyrosine-protein kinase Mer TK tyrosine-protein kinase AXL C00018055 1 / 1
Q00535 Cyclin-dependent kinase 5 Cdk5 C00018055 0 / 0
Q15078 Cyclin-dependent kinase 5 activator 1 REG serine/threonine protein kinase family C00018055 0 / 0
Q9Y5S2 Serine/threonine-protein kinase MRCK beta AGC serine/threonine protein kinase GEK subfamily C00018055 0 / 0
Q8N4C8 Misshapen-like kinase 1 STE serine/threonine protein kinase MSN subfamily C00018055 0 / 0
Q9NYY3 Serine/threonine-protein kinase PLK2 Plk2 C00018055 0 / 0
P43250 G protein-coupled receptor kinase 6 AGC serine/threonine protein kinase GRK subfamily C00018055 0 / 0
Q96BR1 Serine/threonine-protein kinase Sgk3 AGC serine/threonine protein kinase SGK subfamily C00018055 0 / 0
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily C00018055 1 / 8
P11473 Vitamin D3 receptor NR1I1 C00018055 2 / 3
P14416 D(2) dopamine receptor Dopamine receptor C00018055 2 / 0
P23219 Prostaglandin G/H synthase 1 Oxidoreductase C00018055 0 / 0
P37288 Vasopressin V1a receptor Vasopressin and oxytocin receptor C00018055 0 / 0
P41145 Kappa-type opioid receptor Opioid receptor C00018055 0 / 0
Q9Y271 Cysteinyl leukotriene receptor 1 Leukotriene receptor C00018055 0 / 0
P29274 Adenosine receptor A2a Adenosine receptor C00018055 0 / 0
O43293 Death-associated protein kinase 3 Dapk C00018055 0 / 0
Q15746 Myosin light chain kinase, smooth muscle Mlck C00018055 1 / 1
Q13188 Serine/threonine-protein kinase 3 STE serine/threonine protein kinase MST subfamily C00018055 0 / 0
P25929 Neuropeptide Y receptor type 1 Neuropeptide Y receptor C00018055 0 / 0
P31751 RAC-beta serine/threonine-protein kinase Akt C00018055 2 / 2
Q9Y243 RAC-gamma serine/threonine-protein kinase Akt C00018055 1 / 0
O75582 Ribosomal protein S6 kinase alpha-5 CAMK serine/threonine protein kinase MSKB subfamily C00018055 0 / 0
P50052 Type-2 angiotensin II receptor Angiotensin receptor C00018055 1 / 1
O14920 Inhibitor of nuclear factor kappa-B kinase subunit beta Other serine/threonine protein kinase C00018055 0 / 0
Q13464 Rho-associated protein kinase 1 Rock C00018055 0 / 0
Q16513 Serine/threonine-protein kinase N2 Pkn C00018055 0 / 0
Q15139 Serine/threonine-protein kinase D1 Pkd C00018055 0 / 0
P17948 Vascular endothelial growth factor receptor 1 Vegfr C00018055 0 / 0
P41968 Melanocortin receptor 3 Melanocortin receptor C00018055 1 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00018055 0 / 0
P78368 Casein kinase I isoform gamma-2 Ck1 C00018055 0 / 0
Q02790 Peptidyl-prolyl cis-trans isomerase FKBP4 Enzyme C00017631 0 / 0
P36888 Receptor-type tyrosine-protein kinase FLT3 Pdgfr C00018055 1 / 1
P07947 Tyrosine-protein kinase Yes Src C00018055 0 / 0
P51617 Interleukin-1 receptor-associated kinase 1 Irak C00018055 0 / 0
Q9NWZ3 Interleukin-1 receptor-associated kinase 4 Irak C00018055 2 / 1
O43353 Receptor-interacting serine/threonine-protein kinase 2 Ripk C00018055 0 / 0
P11509 Cytochrome P450 2A6 Cytochrome P450 2A6 C00018055 0 / 0
P29320 Ephrin type-A receptor 3 Eph C00018055 1 / 0
P54764 Ephrin type-A receptor 4 Eph C00018055 0 / 0
Q8N5S9 Calcium/calmodulin-dependent protein kinase kinase 1 META serine/threonine protein kinase subfamily C00018055 0 / 0
Q9P286 Serine/threonine-protein kinase PAK 7 STE serine/threonine protein kinase PAKB subfamily C00018055 0 / 0
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor C00018055 0 / 0
Q16620 BDNF/NT-3 growth factors receptor Trk C00018055 1 / 1
P42680 Tyrosine-protein kinase Tec Tec C00018055 0 / 0
P42681 Tyrosine-protein kinase TXK Tec C00018055 0 / 0
Q96SB4 SRSF protein kinase 1 Srpk C00018055 0 / 0
Q92630 Dual specificity tyrosine-phosphorylation-regulated kinase 2 CMGC dual-specificity kinase DYRK2 C00018055 0 / 0
O43781 Dual specificity tyrosine-phosphorylation-regulated kinase 3 CMGC dual-specificity kinase DYRK2 C00018055 0 / 0
P07332 Tyrosine-protein kinase Fes/Fps Fer C00018055 0 / 0
O96013 Serine/threonine-protein kinase PAK 4 STE serine/threonine protein kinase PAKB subfamily C00018055 0 / 0
P09769 Tyrosine-protein kinase Fgr Src C00018055 0 / 0
P54760 Ephrin type-B receptor 4 Eph C00018055 0 / 0
P39748 Flap endonuclease 1 Enzyme C00018055 0 / 0
Q09013 Myotonin-protein kinase AGC serine/threonine protein kinase GEK subfamily C00018055 1 / 1
Q16832 Discoidin domain-containing receptor 2 Ddr C00018055 1 / 1
Q8IYT8 Serine/threonine-protein kinase ULK2 ULK serine/threonine protein kinase C00018055 0 / 0
Q9BYT3 Serine/threonine-protein kinase 33 Unique CAMK serine/threonine protein kinase C00018055 0 / 0
P57059 Serine/threonine-protein kinase SIK1 CAMK serine/threonine protein kinase QIK subfamily C00018055 0 / 0
P78362 SRSF protein kinase 2 Srpk C00018055 0 / 0
Q9HBY8 Serine/threonine-protein kinase Sgk2 AGC serine/threonine protein kinase SGK subfamily C00018055 0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00018055 2 / 0
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00018055 1 / 0
Q86Y07 Serine/threonine-protein kinase VRK2 Enzyme C00018055 0 / 0
Q9Y3S1 Serine/threonine-protein kinase WNK2 WNK serine/threonine protein kinase subfamily C00018055 0 / 0
P04035 3-hydroxy-3-methylglutaryl-coenzyme A reductase Oxidoreductase C00018055 0 / 0
P08913 Alpha-2A adrenergic receptor Adrenergic receptor C00018055 0 / 0
P21917 D(4) dopamine receptor Dopamine receptor C00018055 0 / 0
P30988 Calcitonin receptor Calcitonin receptor C00018055 0 / 0
P35462 D(3) dopamine receptor Dopamine receptor C00018055 1 / 0
P41143 Delta-type opioid receptor Opioid receptor C00018055 0 / 0
Q92731 Estrogen receptor beta NR3A2 C00018055 0 / 1
P41595 5-hydroxytryptamine receptor 2B Serotonin receptor C00018055 0 / 0
P25101 Endothelin-1 receptor Endothelin receptor C00018055 0 / 0
P30411 B2 bradykinin receptor Bradykinin receptor C00018055 0 / 0
P32245 Melanocortin receptor 4 Melanocortin receptor C00018055 1 / 0
P49841 Glycogen synthase kinase-3 beta Gsk C00018055 0 / 0
P32238 Cholecystokinin receptor type A Cholecystokinin receptor C00018055 0 / 0
P08311 Cathepsin G S1A C00018055 0 / 0
Q15418 Ribosomal protein S6 kinase alpha-1 Rskb C00018055 0 / 0
O15264 Mitogen-activated protein kinase 13 p38 C00018055 0 / 0
P42684 Abelson tyrosine-protein kinase 2 Abl C00018055 0 / 0
Q05397 Focal adhesion kinase 1 Fak C00018055 0 / 0
Q99720 Sigma non-opioid intracellular receptor 1 Membrane receptor C00018055 1 / 0
P53779 Mitogen-activated protein kinase 10 Jnk C00018055 0 / 1
P29323 Ephrin type-B receptor 2 Eph C00018055 2 / 0
O75914 Serine/threonine-protein kinase PAK 3 STE serine/threonine protein kinase PAKA subfamily C00018055 1 / 1
P15735 Phosphorylase b kinase gamma catalytic chain, liver/testis isoform Phk C00018055 1 / 1
Q02763 Angiopoietin-1 receptor Tie C00018055 1 / 1
P03956 Interstitial collagenase M10A C00018055 0 / 1
P29317 Ephrin type-A receptor 2 Eph C00018055 1 / 1
P51955 Serine/threonine-protein kinase Nek2 Nek C00018055 0 / 0
Q15375 Ephrin type-A receptor 7 Eph C00018055 0 / 0
Q96RR4 Calcium/calmodulin-dependent protein kinase kinase 2 META serine/threonine protein kinase subfamily C00018055 0 / 0
Q99683 Mitogen-activated protein kinase kinase kinase 5 Ste11 C00018055 0 / 0
P32241 Vasoactive intestinal polypeptide receptor 1 Vasoactive intestinal peptide receptor C00018055 0 / 0
Q9H4B4 Serine/threonine-protein kinase PLK3 PLK serine/threonine protein kinase subfamily C00018055 0 / 0
P54753 Ephrin type-B receptor 3 Eph C00018055 0 / 0
Q9UM73 ALK tyrosine kinase receptor TKL serine/threonine protein kinase STKR type 1 subfamily C00018055 1 / 1
Q9BUB5 MAP kinase-interacting serine/threonine-protein kinase 1 CAMK serine/threonine protein kinase MNK subfamily C00018055 0 / 0
O15146 Muscle, skeletal receptor tyrosine-protein kinase Musk C00018055 1 / 1
O60285 NUAK family SNF1-like kinase 1 CAMK serine/threonine protein kinase NUAK subfamily C00018055 0 / 0
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00017631 1 / 2
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00018055 0 / 0
Q96RG2 PAS domain-containing serine/threonine-protein kinase Pask C00018055 0 / 0
P34947 G protein-coupled receptor kinase 5 AGC serine/threonine protein kinase GRK subfamily C00018055 0 / 0
P04150 Glucocorticoid receptor NR3C1 C00018055 0 / 1
P06213 Insulin receptor TK tyrosine-protein kinase INSR subfamily C00018055 5 / 4
P08172 Muscarinic acetylcholine receptor M2 Acetylcholine receptor C00018055 2 / 0
P11229 Muscarinic acetylcholine receptor M1 Acetylcholine receptor C00018055 0 / 0
P21554 Cannabinoid receptor 1 Cannabinoid receptor C00018055 0 / 0
P31645 Sodium-dependent serotonin transporter Serotonin C00018055 2 / 0
P04626 Receptor tyrosine-protein kinase erbB-2 TK tyrosine-protein kinase EGFR subfamily C00018055 5 / 9
P09619 Platelet-derived growth factor receptor beta Pdgfr C00018055 5 / 1
P20309 Muscarinic acetylcholine receptor M3 Acetylcholine receptor C00018055 1 / 0
P21452 Substance-K receptor Neurokinin receptor C00018055 0 / 0
P52564 Dual specificity mitogen-activated protein kinase kinase 6 Ste7 C00018055 0 / 0
P48730 Casein kinase I isoform delta Ck1 C00018055 1 / 0
P12931 Proto-oncogene tyrosine-protein kinase Src Src C00018055 0 / 0
P51679 C-C chemokine receptor type 4 CC chemokine receptor C00018055 0 / 0
P51681 C-C chemokine receptor type 5 CC chemokine receptor C00018055 3 / 0
P50406 5-hydroxytryptamine receptor 6 Serotonin receptor C00018055 0 / 0
O15111 Inhibitor of nuclear factor kappa-B kinase subunit alpha Other serine/threonine protein kinase C00018055 1 / 1
Q96GD4 Aurora kinase B Aur C00018055 0 / 0
O75676 Ribosomal protein S6 kinase alpha-4 CAMK serine/threonine protein kinase MSKB subfamily C00018055 0 / 0
P05129 Protein kinase C gamma type Alpha C00018055 1 / 1
O60674 Tyrosine-protein kinase JAK2 Jakb C00018055 5 / 1
P35968 Vascular endothelial growth factor receptor 2 Vegfr C00018055 1 / 0
P49137 MAP kinase-activated protein kinase 2 CAMK serine/threonine protein kinase MAPKAPK C00018055 0 / 0
P08581 Hepatocyte growth factor receptor TK tyrosine-protein kinase MET subfamily C00018055 2 / 3
P41597 C-C chemokine receptor type 2 CC chemokine receptor C00018055 1 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00018055 0 / 0
P35916 Vascular endothelial growth factor receptor 3 Vegfr C00018055 2 / 1
P22455 Fibroblast growth factor receptor 4 Fgfr C00018055 0 / 0
P22607 Fibroblast growth factor receptor 3 Fgfr C00018055 14 / 6
P08575 Receptor-type tyrosine-protein phosphatase C Enzyme C00018055 2 / 1
P45983 Mitogen-activated protein kinase 8 Jnk C00018055 0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00018055 0 / 0
O94804 Serine/threonine-protein kinase 10 STE serine/threonine protein kinase SLK subfamily C00018055 1 / 0
P53667 LIM domain kinase 1 Limk C00018055 0 / 0
Q13177 Serine/threonine-protein kinase PAK 2 STE serine/threonine protein kinase PAKA subfamily C00018055 0 / 0
Q06418 Tyrosine-protein kinase receptor TYRO3 TK tyrosine-protein kinase AXL C00018055 0 / 0
Q6PHR2 Serine/threonine-protein kinase ULK3 ULK serine/threonine protein kinase C00018055 0 / 0
Q7L7X3 Serine/threonine-protein kinase TAO1 STE serine/threonine protein kinase TAO subfamily C00018055 0 / 0
P14616 Insulin receptor-related protein TK tyrosine-protein kinase INSR C00018055 0 / 0
O43318 Mitogen-activated protein kinase kinase kinase 7 Tak1 C00018055 0 / 0
Q9BXA7 Testis-specific serine/threonine-protein kinase 1 Tssk C00018055 0 / 0
Q9H2K8 Serine/threonine-protein kinase TAO3 STE serine/threonine protein kinase TAO subfamily C00018055 0 / 0
Q13555 Calcium/calmodulin-dependent protein kinase type II subunit gamma Camk2 C00018055 0 / 0
Q8NG66 Serine/threonine-protein kinase Nek11 Nek11 C00018055 0 / 0
Q8WTQ7 G protein-coupled receptor kinase 7 AGC serine/threonine protein kinase GRK subfamily C00018055 0 / 0
Q8TF76 Serine/threonine-protein kinase haspin Haspin C00018055 0 / 0
O76074 cGMP-specific 3',5'-cyclic phosphodiesterase PDE_5A C00018055 0 / 0
P03372 Estrogen receptor NR3A1 C00018055 1 / 1
P08588 Beta-1 adrenergic receptor Adrenergic receptor C00018055 1 / 0
P36897 TGF-beta receptor type-1 TKL dual-specificity kinase STKR type 1 subfamily C00018055 3 / 2
P22303 Acetylcholinesterase Hydrolase C00018055 1 / 0
P28223 5-hydroxytryptamine receptor 2A Serotonin receptor C00018055 0 / 0
P28335 5-hydroxytryptamine receptor 2C Serotonin receptor C00018055 0 / 0
P35372 Mu-type opioid receptor Opioid receptor C00018055 0 / 0
P08173 Muscarinic acetylcholine receptor M4 Acetylcholine receptor C00018055 0 / 0
P25103 Substance-P receptor Neurokinin receptor C00018055 0 / 0
P25105 Platelet-activating factor receptor PAF receptor C00018055 0 / 0
P11362 Fibroblast growth factor receptor 1 Fgfr C00018055 4 / 5
P53350 Serine/threonine-protein kinase PLK1 PLK serine/threonine protein kinase subfamily C00018055 0 / 0
Q08881 Tyrosine-protein kinase ITK/TSK Tec C00018055 1 / 1
P33032 Melanocortin receptor 5 Melanocortin receptor C00018055 0 / 0
P49840 Glycogen synthase kinase-3 alpha Gsk C00018055 0 / 0
Q13976 cGMP-dependent protein kinase 1 Pkg C00018055 0 / 0
Q8IW41 MAP kinase-activated protein kinase 5 CAMK serine/threonine protein kinase MAPKAPK C00018055 0 / 0
O75116 Rho-associated protein kinase 2 Rock C00018055 0 / 0
P05771 Protein kinase C beta type Alpha C00018055 0 / 0
P08631 Tyrosine-protein kinase HCK Src C00018055 0 / 0
P07948 Tyrosine-protein kinase Lyn Src C00018055 0 / 0
P31749 RAC-alpha serine/threonine-protein kinase Akt C00018055 4 / 1
Q15118 [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial Pdhk C00018055 0 / 0
O00141 Serine/threonine-protein kinase Sgk1 AGC serine/threonine protein kinase SGK subfamily C00018055 0 / 0
P51812 Ribosomal protein S6 kinase alpha-3 Rskb C00018055 2 / 2
P07333 Macrophage colony-stimulating factor 1 receptor Pdgfr C00018055 1 / 1
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00018055 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00018055 0 / 1
P05181 Cytochrome P450 2E1 Cytochrome P450 2E1 C00018055 0 / 0
P16591 Tyrosine-protein kinase Fer Fer C00018055 0 / 0
Q8IU85 Calcium/calmodulin-dependent protein kinase type 1D Camk1 C00018055 0 / 0
Q9HC98 Serine/threonine-protein kinase Nek6 Nek C00018055 0 / 0
Q9UEE5 Serine/threonine-protein kinase 17A Dapk C00018055 0 / 0
P07949 Proto-oncogene tyrosine-protein kinase receptor Ret Ret C00018055 9 / 4
Q9H2X6 Homeodomain-interacting protein kinase 2 CMGC dual-specificity kinase HIPK C00018055 0 / 0
P36896 Activin receptor type-1B TKL serine/threonine protein kinase STKR type 1 subfamily C00018055 0 / 0
Q86UE8 Serine/threonine-protein kinase tousled-like 2 TLK serine/threonine protein kinase C00018055 0 / 0
Q86Z02 Homeodomain-interacting protein kinase 1 CMGC serine/threonine protein kinase HIPK subfamily C00018055 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00017631 0 / 0
Q02750 Dual specificity mitogen-activated protein kinase kinase 1 Ste7 C00018055 1 / 1
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00018055 0 / 0
P23975 Sodium-dependent noradrenaline transporter Norepinephrine C00018055 1 / 1
P25100 Alpha-1D adrenergic receptor Adrenergic receptor C00018055 0 / 0
P30542 Adenosine receptor A1 Adenosine receptor C00018055 0 / 0
P18089 Alpha-2B adrenergic receptor Adrenergic receptor C00018055 0 / 0
P10721 Mast/stem cell growth factor receptor Kit Pdgfr C00018055 4 / 3
P24557 Thromboxane-A synthase Cytochrome P450 5A1 C00018055 1 / 1
P06239 Tyrosine-protein kinase Lck Src C00018055 0 / 1
Q9HCP0 Casein kinase I isoform gamma-1 Ck1 C00018055 0 / 0
Q13554 Calcium/calmodulin-dependent protein kinase type II subunit beta Camk2 C00018055 0 / 0
O96017 Serine/threonine-protein kinase Chk2 Rad53 C00018055 4 / 1
P25025 C-X-C chemokine receptor type 2 CXC chemokine receptor C00018055 0 / 0
P52333 Tyrosine-protein kinase JAK3 Jakb C00018055 1 / 1
P04049 RAF proto-oncogene serine/threonine-protein kinase Raf C00018055 2 / 0
P43405 Tyrosine-protein kinase SYK Syk C00018055 0 / 0
Q14012 Calcium/calmodulin-dependent protein kinase type 1 Camk1 C00018055 0 / 0
Q16566 Calcium/calmodulin-dependent protein kinase type IV Camk1 C00018055 0 / 0
P53355 Death-associated protein kinase 1 Dapk C00018055 0 / 1
P24723 Protein kinase C eta type Eta C00018055 1 / 0
P51451 Tyrosine-protein kinase Blk Src C00018055 1 / 1
P17612 cAMP-dependent protein kinase catalytic subunit alpha Pka C00018055 0 / 0
Q13627 Dual specificity tyrosine-phosphorylation-regulated kinase 1A CMGC dual-specificity kinase DYRK1 C00018055 1 / 0
O14733 Dual specificity mitogen-activated protein kinase kinase 7 Ste7 C00018055 0 / 0
P53778 Mitogen-activated protein kinase 12 p38 C00018055 0 / 0
O00418 Eukaryotic elongation factor 2 kinase Atypical serine/threonine protein kinase alpha subfamily C00018055 0 / 0
P29322 Ephrin type-A receptor 8 Eph C00018055 0 / 0
P49760 Dual specificity protein kinase CLK2 Clk C00018055 0 / 0
P54756 Ephrin type-A receptor 5 Eph C00018055 0 / 0
P54762 Ephrin type-B receptor 1 Eph C00018055 0 / 0
Q07912 Activated CDC42 kinase 1 TK tyrosine-protein kinase ACK subfamily C00018055 0 / 0
P30530 Tyrosine-protein kinase receptor UFO TK tyrosine-protein kinase AXL subfamily C00018055 0 / 0
Q9BZL6 Serine/threonine-protein kinase D2 Pkd C00018055 0 / 0
Q8TD08 Mitogen-activated protein kinase 15 Mapk C00018055 0 / 0
P06730 Eukaryotic translation initiation factor 4E Other nuclear protein C00018055 1 / 0
Q86V86 Serine/threonine-protein kinase pim-3 Pim C00018055 0 / 0
Q9UPE1 SRSF protein kinase 3 Srpk C00018055 0 / 0
Q9Y6E0 Serine/threonine-protein kinase 24 STE serine/threonine protein kinase YSK subfamily C00018055 0 / 0
Q9Y6M4 Casein kinase I isoform gamma-3 Ck1-g C00018055 0 / 0
Q8N568 Serine/threonine-protein kinase DCLK2 CAMK serine/threonine protein kinase DCAMK1 C00018055 0 / 0
Q8TDC3 Serine/threonine-protein kinase BRSK1 CAMK serine/threonine protein kinase BRSK subfamily C00018055 0 / 0
P51817 cAMP-dependent protein kinase catalytic subunit PRKX Pka C00018055 0 / 0
Q53EL6 Programmed cell death protein 4 Unclassified protein C00018055 0 / 0
P42345 Serine/threonine-protein kinase mTOR Enzyme C00018055 0 / 0
Q9UL54 Serine/threonine-protein kinase TAO2 STE serine/threonine protein kinase TAO subfamily C00018055 0 / 0
Q13451 Peptidyl-prolyl cis-trans isomerase FKBP5 Enzyme C00018055 0 / 0
O00255 Menin Unclassified protein C00017631 2 / 5
P51946 Cyclin-H Other cytosolic protein C00018055 0 / 0
P50613 Cyclin-dependent kinase 7 Cdk7 C00018055 0 / 0
P24864 G1/S-specific cyclin-E1 Other cytosolic protein C00018055 0 / 2
P24941 Cyclin-dependent kinase 2 Cdc2 C00018055 0 / 0
O96020 G1/S-specific cyclin-E2 Other cytosolic protein C00018055 0 / 2
O95067 G2/mitotic-specific cyclin-B2 Other cytosolic protein C00018055 0 / 0
P14635 G2/mitotic-specific cyclin-B1 Other cytosolic protein C00018055 0 / 0
P06493 Cyclin-dependent kinase 1 Cdc2 C00018055 0 / 0
Q8WWL7 G2/mitotic-specific cyclin-B3 Other cytosolic protein C00018055 0 / 0
P20248 Cyclin-A2 Other cytosolic protein C00018055 0 / 0
P78396 Cyclin-A1 Other cytosolic protein C00018055 0 / 0
P68400 Casein kinase II subunit alpha Ck2 C00018055 0 / 0
P67870 Casein kinase II subunit beta REG serine/threonine protein kinase family C00018055 0 / 0
P54619 5'-AMP-activated protein kinase subunit gamma-1 REG serine/threonine protein kinase family C00018055 0 / 0
Q9Y478 5'-AMP-activated protein kinase subunit beta-1 REG serine/threonine protein kinase family C00018055 0 / 0
P54646 5'-AMP-activated protein kinase catalytic subunit alpha-2 Ampk C00018055 0 / 0
Q13131 5'-AMP-activated protein kinase catalytic subunit alpha-1 Ampk C00018055 0 / 0
O43741 5'-AMP-activated protein kinase subunit beta-2 REG serine/threonine protein kinase family C00018055 0 / 0
Q9UGJ0 5'-AMP-activated protein kinase subunit gamma-2 REG serine/threonine protein kinase family C00018055 3 / 3
O60563 Cyclin-T1 Other cytosolic protein C00018055 0 / 0
P50750 Cyclin-dependent kinase 9 Cdk9 C00018055 0 / 0
Q00526 Cyclin-dependent kinase 3 Cdc2 C00018055 0 / 0
Q00534 Cyclin-dependent kinase 6 CMGC serine/threonine protein kinase family C00018055 1 / 0
P30281 G1/S-specific cyclin-D3 Other cytosolic protein C00018055 0 / 1
Q9UGI9 5'-AMP-activated protein kinase subunit gamma-3 Kinase C00018055 0 / 0

225 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
4137 MAPT, DDPAC, FTDP-17, MAPTL, MSTD, MTBT1, MTBT2, PPND, TAU microtubule-associated protein tau C00017631
19 ABCA1, ABC-1, ABC1, CERP, HDLDT1, TGD ATP-binding cassette, sub-family A (ABC1), member 1 C00018055
5243 ABCB1, ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) C00018055
340485 ACER2, ALKCDase2, ASAH3L alkaline ceramidase 2 (EC:3.5.1.23) C00018055
59 ACTA2, AAT6, ACTSA, MYMY5 actin, alpha 2, smooth muscle, aorta C00018055
9131 AIFM1, AIF, CMTX4, COWCK, COXPD6, PDCD8 apoptosis-inducing factor, mitochondrion-associated, 1 C00018055
207 AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) C00018055
208 AKT2, HIHGHH, PKBB, PKBBETA, PRKBB, RAC-BETA v-akt murine thymoma viral oncogene homolog 2 (EC:2.7.11.1) C00018055
351 APP, AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN-II, PN2 amyloid beta (A4) precursor protein C00018055
367 AR, AIS, DHTR, HUMARA, HYSP1, KD, NR3C4, SBMA, SMAX1, TFM androgen receptor C00018055
9474 ATG5, APG5, APG5-LIKE, APG5L, ASP, hAPG5 autophagy related 5 C00018055
9212 AURKB, AIK2, AIM-1, AIM1, ARK2, AurB, IPL1, PPP1R48, STK12, STK5, aurkb-sv1, aurkb-sv2 aurora kinase B (EC:2.7.11.1) C00018055
581 BAX, BCL2L4 BCL2-associated X protein C00018055
27113 BBC3, JFY-1, JFY1, PUMA BCL2 binding component 3 C00018055
596 BCL2, Bcl-2, PPP1R50 B-cell CLL/lymphoma 2 C00018055
598 BCL2L1, BCL-XL/S, BCL2L, BCLX, BCLXL, BCLXS, Bcl-X, PPP1R52, bcl-xL, bcl-xS BCL2-like 1 C00018055
10018 BCL2L11, BAM, BIM, BOD BCL2-like 11 (apoptosis facilitator) C00018055
8678 BECN1, ATG6, VPS30, beclin1 beclin 1, autophagy related C00018055
637 BID, FP497 BH3 interacting domain death agonist C00018055
329 BIRC2, API1, HIAP2, Hiap-2, MIHB, RNF48, c-IAP1, cIAP1 baculoviral IAP repeat containing 2 C00018055
332 BIRC5, API4, EPR-1 baculoviral IAP repeat containing 5 C00018055
121551 BTBD11, ABTB2B BTB (POZ) domain containing 11 C00018055
699 BUB1, BUB1A, BUB1L, hBUB1 BUB1 mitotic checkpoint serine/threonine kinase (EC:2.7.11.1) C00018055
701 BUB1B, BUB1beta, BUBR1, Bub1A, MAD3L, MVA1, SSK1, hBUBR1 BUB1 mitotic checkpoint serine/threonine kinase B (EC:2.7.11.1) C00018055
84909 C9orf3, AOPEP, AP-O, APO, C90RF3, ONPEP chromosome 9 open reading frame 3 C00018055
800 CALD1, CDM, H-CAD, HCAD, L-CAD, LCAD, NAG22 caldesmon 1 C00018055
835 CASP2, CASP-2, ICH1, NEDD-2, NEDD2, PPP1R57 caspase 2, apoptosis-related cysteine peptidase (EC:3.4.22.55) C00018055
836 CASP3, CPP32, CPP32B, SCA-1 caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) C00018055
840 CASP7, CASP-7, CMH-1, ICE-LAP3, LICE2, MCH3 caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) C00018055
841 CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5 caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) C00018055
842 CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56 caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) C00018055
859 CAV3, LGMD1C, LQT9, VIP-21, VIP21 caveolin 3 C00018055
890 CCNA2, CCN1, CCNA cyclin A2 C00018055
9133 CCNB2, HsT17299 cyclin B2 C00018055
595 CCND1, BCL1, D11S287E, PRAD1, U21B31 cyclin D1 C00018055
894 CCND2, KIAK0002 cyclin D2 C00018055
896 CCND3 cyclin D3 C00018055
9134 CCNE2, CYCE2 cyclin E2 C00018055
901 CCNG2 cyclin G2 C00018055
948 CD36, BDPLT10, CHDS7, FAT, GP3B, GP4, GPIV, PASIV, SCARB3 CD36 molecule (thrombospondin receptor) C00018055
968 CD68, GP110, LAMP4, SCARD1 CD68 molecule C00018055
991 CDC20, CDC20A, bA276H19.3, p55CDC cell division cycle 20 C00018055
983 CDK1, CDC2, CDC28A, P34CDC2 cyclin-dependent kinase 1 (EC:2.7.11.23 2.7.11.22) C00018055
1017 CDK2, p33(CDK2) cyclin-dependent kinase 2 (EC:2.7.11.22) C00018055
1026 CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 cyclin-dependent kinase inhibitor 1A (p21, Cip1) C00018055
1027 CDKN1B, CDKN4, KIP1, MEN1B, MEN4, P27KIP1 cyclin-dependent kinase inhibitor 1B (p27, Kip1) C00018055
1142 CHRNB3 cholinergic receptor, nicotinic, beta 3 (neuronal) C00018055
1278 COL1A2, OI4 collagen, type I, alpha 2 C00018055
1593 CYP27A1, CP27, CTX, CYP27 cytochrome P450, family 27, subfamily A, polypeptide 1 (EC:1.14.13.15) C00018055
1574 C00018055
1576 CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1 cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) C00018055
1649 DDIT3, CEBPZ, CHOP, CHOP-10, CHOP10, GADD153 DNA-damage-inducible transcript 3 C00018055
420357 C00018055
56616 DIABLO, DFNA64, SMAC diablo, IAP-binding mitochondrial protein C00018055
1786 DNMT1, ADCADN, AIM, CXXC9, DNMT, HSN1E, MCMT DNA (cytosine-5-)-methyltransferase 1 (EC:2.1.1.37) C00018055
1806 DPYD, DHP, DHPDHASE, DPD dihydropyrimidine dehydrogenase (EC:1.3.1.2) C00018055
1869 E2F1, E2F-1, RBAP1, RBBP3, RBP3 E2F transcription factor 1 C00018055
1874 E2F4, E2F-4 E2F transcription factor 4, p107/p130-binding C00018055
1950 EGF, HOMG4, URG epidermal growth factor C00018055
1956 EGFR, ERBB, ERBB1, HER1, PIG61, mENA epidermal growth factor receptor (EC:2.7.10.1) C00018055
1977 EIF4E, AUTS19, CBP, EIF4E1, EIF4EL1, EIF4F eukaryotic translation initiation factor 4E C00018055
1978 EIF4EBP1, 4E-BP1, 4EBP1, BP-1, PHAS-I eukaryotic translation initiation factor 4E binding protein 1 C00018055
1982 EIF4G2, AAG1, DAP5, NAT1, P97 eukaryotic translation initiation factor 4 gamma, 2 C00018055
9700 ESPL1, ESP1, SEPA extra spindle pole bodies homolog 1 (S. cerevisiae) (EC:3.4.22.49) C00018055
2099 ESR1, ER, ESR, ESRA, ESTRR, Era, NR3A1 estrogen receptor 1 C00018055
2130 EWSR1, EWS, bK984G1.4 EWS RNA-binding protein 1 C00018055
2152 F3, CD142, TF, TFA coagulation factor III (thromboplastin, tissue factor) C00018055
356 FASLG, ALPS1B, APT1LG1, APTL, CD178, CD95-L, CD95L, FASL, TNFSF6 Fas ligand (TNF superfamily, member 6) C00018055
10826 FAXDC2, C5orf4 fatty acid hydroxylase domain containing 2 C00018055
114907 FBXO32, Fbx32, MAFbx F-box protein 32 C00018055
26271 FBXO5, EMI1, FBX5, Fbxo31 F-box protein 5 C00018055
2252 FGF7, HBGF-7, KGF fibroblast growth factor 7 C00018055
2280 FKBP1A, FKBP-12, FKBP-1A, FKBP1, FKBP12, PKC12, PKCI2, PPIASE FK506 binding protein 1A, 12kDa (EC:5.2.1.8) C00018055
2348 FOLR1, FBP, FOLR folate receptor 1 (adult) C00018055
2305 FOXM1, FKHL16, FOXM1B, HFH-11, HFH11, HNF-3, INS-1, MPHOSPH2, MPP-2, MPP2, PIG29, TGT3, TRIDENT forkhead box M1 C00018055
2308 FOXO1, FKH1, FKHR, FOXO1A forkhead box O1 C00018055
494532 C00018055
50943 FOXP3, AIID, DIETER, IPEX, PIDX, XPID forkhead box P3 C00018055
2512 FTL, NBIA3 ferritin, light polypeptide C00018055
9247 GCM2, GCMB, hGCMb glial cells missing homolog 2 (Drosophila) C00018055
2932 GSK3B glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26) C00018055
2952 GSTT1 glutathione S-transferase theta 1 (EC:2.5.1.18) C00018055
3002 GZMB, CCPI, CGL-1, CGL1, CSP-B, CSPB, CTLA1, CTSGL1, HLP, SECT granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) (EC:3.4.21.79) C00018055
36301 C00018055
3280 HES1, HES-1, HHL, HRY, bHLHb39 hes family bHLH transcription factor 1 C00018055
3091 HIF1A, HIF-1A, HIF-1alpha, HIF1, HIF1-ALPHA, MOP1, PASD8, bHLHe78 hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) C00018055
3156 HMGCR, LDLCQ3 3-hydroxy-3-methylglutaryl-CoA reductase (EC:1.1.1.34) C00018055
3205 HOXA9, ABD-B, HOX1, HOX1.7, HOX1G homeobox A9 C00018055
26353 HSPB8, CMT2L, DHMN2, E2IG1, H11, HMN2, HMN2A, HSP22 heat shock 22kDa protein 8 C00018055
3458 IFNG, IFG, IFI interferon, gamma C00018055
3479 IGF1, IGF-I, IGF1A, IGFI insulin-like growth factor 1 (somatomedin C) C00018055
3480 IGF1R, CD221, IGFIR, IGFR, JTK13 insulin-like growth factor 1 receptor (EC:2.7.10.1) C00018055
3486 IGFBP3, BP-53, IBP3 insulin-like growth factor binding protein 3 C00018055
3586 IL10, CSIF, GVHDS, IL-10, IL10A, TGIF interleukin 10 C00018055
55540 IL17RB, CRL4, EVI27, IL17BR, IL17RH1 interleukin 17 receptor B C00018055
3558 IL2, IL-2, TCGF, lymphokine interleukin 2 C00018055
3559 IL2RA, CD25, IDDM10, IL2R, TCGFR interleukin 2 receptor, alpha C00018055
3569 IL6, BSF2, HGF, HSF, IFNB2, IL-6 interleukin 6 (interferon, beta 2) C00018055
3576 IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 interleukin 8 C00018055
51147 ING4, my036, p29ING4 inhibitor of growth family, member 4 C00018055
3667 IRS1, HIRS-1 insulin receptor substrate 1 C00018055
3684 ITGAM, CD11B, CR3A, MAC-1, MAC1A, MO1A, SLEB6 integrin, alpha M (complement component 3 receptor 3 subunit) C00018055
182 JAG1, AGS, AHD, AWS, CD339, HJ1, JAGL1 jagged 1 C00018055
133746 JMY, WHDC1L3 junction mediating and regulatory protein, p53 cofactor C00018055
3815 KIT, C-Kit, CD117, PBT, SCFR v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog (EC:2.7.10.1) C00018055
3817 KLK2, KLK2A2, hGK-1, hK2 kallikrein-related peptidase 2 (EC:3.4.21.35) C00018055
354 KLK3, APS, KLK2A1, PSA, hK3 kallikrein-related peptidase 3 (EC:3.4.21.77) C00018055
3897 L1CAM, CAML1, CD171, HSAS, HSAS1, MASA, MIC5, N-CAM-L1, N-CAML1, NCAM-L1, S10, SPG1 L1 cell adhesion molecule C00018055
4085 MAD2L1, HSMAD2, MAD2 MAD2 mitotic arrest deficient-like 1 (yeast) C00018055
84557 MAP1LC3A, ATG8E, LC3, LC3A, MAP1ALC3, MAP1BLC3 microtubule-associated protein 1 light chain 3 alpha C00018055
81631 MAP1LC3B, ATG8F, LC3B, MAP1A/1BLC3, MAP1LC3B-a microtubule-associated protein 1 light chain 3 beta C00018055
5604 MAP2K1, CFC3, MAPKK1, MEK1, MKK1, PRKMK1 mitogen-activated protein kinase kinase 1 (EC:2.7.12.2) C00018055
5605 MAP2K2, CFC4, MAPKK2, MEK2, MKK2, PRKMK2 mitogen-activated protein kinase kinase 2 (EC:2.7.12.2) C00018055
5594 MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk mitogen-activated protein kinase 1 (EC:2.7.11.24) C00018055
5595 MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK mitogen-activated protein kinase 3 (EC:2.7.11.24) C00018055
5599 MAPK8, JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c mitogen-activated protein kinase 8 (EC:2.7.11.24) C00018055
10150 MBNL2, MBLL, MBLL39, PRO2032 muscleblind-like splicing regulator 2 C00018055
4170 MCL1, BCL2L3, EAT, MCL1-ES, MCL1L, MCL1S, Mcl-1, TM, bcl2-L-3, mcl1/EAT myeloid cell leukemia sequence 1 (BCL2-related) C00018055
4193 MDM2, ACTFS, HDMX, hdm2 MDM2 oncogene, E3 ubiquitin protein ligase C00018055
387169 C00018055
406954 MIR181A2, MIRN181A, MIRN181A2, hsa-mir-181a-2 microRNA 181a-2 C00018055
406965 MIR190A, MIR190, MIRN190, hsa-mir-190a, miR-190 microRNA 190a C00018055
407026 MIR29C, MIRN29C, miRNA29C microRNA 29c C00018055
442898 MIR324, MIRN324, hsa-mir-324 microRNA 324 C00018055
494328 MIR379, MIRN379, hsa-mir-379 microRNA 379 C00018055
574034 MIR433, MIRN433, hsa-mir-433, miRNA433 microRNA 433 C00018055
574506 MIR503, MIRN503, hsa-mir-503 microRNA 503 C00018055
574513 MIR508, MIRN508, hsa-mir-508 microRNA 508 C00018055
723778 MIR650, MIRN650, hsa-mir-650 microRNA 650 C00018055
724024 MIR654, MIRN654, hsa-mir-654 microRNA 654 C00018055
768212 MIR758, MIRN758, hsa-mir-758 microRNA 758 C00018055
100126348 MIR760, MIRN760, hsa-mir-760 microRNA 760 C00018055
4288 MKI67, KIA, MIB-1 marker of proliferation Ki-67 C00018055
64223 MLST8, GBL, GbetaL, LST8, POP3, WAT1 MTOR associated protein, LST8 homolog (S. cerevisiae) C00018055
4312 MMP1, CLG, CLGN matrix metallopeptidase 1 (interstitial collagenase) (EC:3.4.24.7) C00018055
4481 MSR1, CD204, SCARA1, SR-A, SRA, phSR1, phSR2 macrophage scavenger receptor 1 C00018055
2475 MTOR, FRAP, FRAP1, FRAP2, RAFT1, RAPT1 mechanistic target of rapamycin (serine/threonine kinase) (EC:2.7.11.1) C00018055
222166 MTURN, C7orf41, Ells1 maturin, neural progenitor differentiation regulator homolog (Xenopus) C00018055
4609 MYC, MRTL, MYCC, bHLHe39, c-Myc v-myc avian myelocytomatosis viral oncogene homolog C00018055
4629 MYH11, AAT4, FAA4, SMHC, SMMHC myosin, heavy chain 11, smooth muscle C00018055
4638 MYLK, AAT7, KRP, MLCK, MLCK1, MLCK108, MLCK210, MSTP083, MYLK1, smMLCK myosin light chain kinase (EC:2.7.11.18) C00018055
26509 MYOF, FER1L3 myoferlin C00018055
10403 NDC80, HEC, HEC1, HsHec1, KNTC2, TID3, hsNDC80 NDC80 kinetochore complex component C00018055
4751 NEK2, HsPK21, NEK2A, NLK1 NIMA-related kinase 2 (EC:2.7.11.1) C00018055
4790 NFKB1, EBP-1, KBF1, NF-kB1, NF-kappa-B, NF-kappaB, NFKB-p105, NFKB-p50, NFkappaB, p105, p50 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 C00018055
4792 NFKBIA, IKBA, MAD-3, NFKBI nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha C00018055
4830 NME1, AWD, GAAD, NB, NBS, NDKA, NDPK-A, NDPKA, NM23, NM23-H1 NME/NM23 nucleoside diphosphate kinase 1 (EC:2.7.4.6) C00018055
10874 NMU neuromedin U C00018055
4846 NOS3, ECNOS, eNOS nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) C00018055
10062 NR1H3, LXR-a, LXRA, RLD-1 nuclear receptor subfamily 1, group H, member 3 C00018055
9971 NR1H4, BAR, FXR, HRR-1, HRR1, RIP14 nuclear receptor subfamily 1, group H, member 4 C00018055
4973 OLR1, CLEC8A, LOX1, LOXIN, SCARE1, SLOX1 oxidized low density lipoprotein (lectin-like) receptor 1 C00018055
5018 OXA1L, OXA1 oxidase (cytochrome c) assembly 1-like C00018055
142 PARP1, ADPRT, ADPRT_1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1 poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) C00018055
7849 PAX8 paired box 8 C00018055
5111 PCNA proliferating cell nuclear antigen C00018055
27250 PDCD4, H731 programmed cell death 4 (neoplastic transformation inhibitor) C00018055
5155 PDGFB, IBGC5, PDGF-2, PDGF2, SIS, SSV, c-sis platelet-derived growth factor beta polypeptide C00018055
5290 PIK3CA, CLOVE, CWS5, MCAP, MCM, MCMTC, PI3K, p110-alpha phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha (EC:2.7.11.1 2.7.1.153) C00018055
5295 PIK3R1, AGM7, GRB1, p85, p85-ALPHA phosphoinositide-3-kinase, regulatory subunit 1 (alpha) C00018055
5315 PKM, CTHBP, OIP3, PK3, PKM2, TCB, THBP1 pyruvate kinase, muscle (EC:2.7.1.40) C00018055
5366 PMAIP1, APR, NOXA phorbol-12-myristate-13-acetate-induced protein 1 C00018055
5468 PPARG, CIMT1, GLM1, NR1C3, PPARG1, PPARG2, PPARgamma peroxisome proliferator-activated receptor gamma C00018055
5551 PRF1, FLH2, HPLH2, P1, PFN1, PFP perforin 1 (pore forming protein) C00018055
5580 PRKCD, MAY1, PKCD, nPKC-delta protein kinase C, delta (EC:2.7.10.2 2.7.11.13) C00018055
5582 PRKCG, PKC-gamma, PKCC, PKCG, SCA14 protein kinase C, gamma (EC:2.7.11.13) C00018055
5583 PRKCH, PKC-L, PKCL, PRKCL, nPKC-eta protein kinase C, eta (EC:2.7.11.13) C00018055
5717 PSMD11, Rpn6, S9, p44.5 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 C00018055
5728 PTEN, 10q23del, BZS, CWS1, DEC, GLM2, MHAM, MMAC1, PTEN1, TEP1 phosphatase and tensin homolog (EC:3.1.3.67 3.1.3.16 3.1.3.48) C00018055
5731 PTGER1, EP1 prostaglandin E receptor 1 (subtype EP1), 42kDa C00018055
9232 PTTG1, EAP1, HPTTG, PTTG, TUTR1 pituitary tumor-transforming 1 C00018055
5888 RAD51, BRCC5, HRAD51, HsRad51, HsT16930, MRMV2, RAD51A, RECA RAD51 recombinase C00018055
5894 RAF1, CRAF, NS5, Raf-1, c-Raf v-raf-1 murine leukemia viral oncogene homolog 1 (EC:2.7.11.1) C00018055
5925 RB1, OSRC, RB, p105-Rb, pRb, pp110 retinoblastoma 1 C00018055
5933 RBL1, CP107, PRB1, p107 retinoblastoma-like 1 (p107) C00018055
5934 RBL2, P130, Rb2 retinoblastoma-like 2 (p130) C00018055
5970 RELA, NFKB3, p65 v-rel avian reticuloendotheliosis viral oncogene homolog A C00018055
5978 REST, NRSF, XBR RE1-silencing transcription factor C00018055
253260 RICTOR, AVO3, PIA, hAVO3 RPTOR independent companion of MTOR, complex 2 C00018055
728380 C00018055
51065 RPS27L ribosomal protein S27-like C00018055
6194 RPS6, S6 ribosomal protein S6 C00018055
6195 RPS6KA1, HU-1, MAPKAPK1A, RSK, RSK1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 (EC:2.7.11.1) C00018055
6198 RPS6KB1, PS6K, S6K, S6K-beta-1, S6K1, STK14A, p70_S6KA, p70(S6K)-alpha, p70-S6K, p70-alpha ribosomal protein S6 kinase, 70kDa, polypeptide 1 (EC:2.7.11.1) C00018055
6199 RPS6KB2, KLS, P70-beta, P70-beta-1, P70-beta-2, S6K-beta2, S6K2, SRK, STK14B, p70(S6K)-beta, p70S6Kb ribosomal protein S6 kinase, 70kDa, polypeptide 2 (EC:2.7.11.1) C00018055
57521 RPTOR, KOG1, Mip1 regulatory associated protein of MTOR, complex 1 C00018055
6236 RRAD, RAD, RAD1, REM3 Ras-related associated with diabetes C00018055
950 SCARB2, AMRF, CD36L2, EPM4, HLGP85, LGP85, LIMP-2, LIMPII, SR-BII scavenger receptor class B, member 2 C00018055
6319 SCD, FADS5, MSTP008, SCD1, SCDOS stearoyl-CoA desaturase (delta-9-desaturase) (EC:1.14.19.1) C00018055
10512 SEMA3C, SEMAE, SemE sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C C00018055
5265 SERPINA1, A1A, A1AT, AAT, PI, PI1, PRO2275, alpha1AT serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 C00018055
5054 SERPINE1, PAI, PAI-1, PAI1, PLANH1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 C00018055
23411 SIRT1, SIR2L1 sirtuin 1 C00018055
22933 SIRT2, SIR2, SIR2L, SIR2L2 sirtuin 2 (EC:3.5.1.-) C00018055
6502 SKP2, FBL1, FBXL1, FLB1, p45 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase C00018055
6564 SLC15A1, HPECT1, HPEPT1, PEPT1 solute carrier family 15 (oligopeptide transporter), member 1 C00018055
201895 SMIM14, C4orf34 small integral membrane protein 14 C00018055
8878 SQSTM1, A170, OSIL, PDB3, ZIP3, p60, p62, p62B sequestosome 1 C00018055
10809 STARD10, NY-CO-28, PCTP2, SDCCAG28 StAR-related lipid transfer (START) domain containing 10 C00018055
6774 STAT3, APRF, HIES signal transducer and activator of transcription 3 (acute-phase response factor) C00018055
412 STS, ARSC, ARSC1, ASC, ES, SSDD, XLI steroid sulfatase (microsomal), isozyme S (EC:3.1.6.2) C00018055
6857 SYT1, P65, SVP65, SYT synaptotagmin I C00018055
6886 TAL1, SCL, TCL5, bHLHa17, tal-1 T-cell acute lymphocytic leukemia 1 C00018055
6941 TCF19, SC1, TCF-19 transcription factor 19 C00018055
7003 TEAD1, AA, NTEF-1, REF1, TCF-13, TCF13, TEAD-1, TEF-1 TEA domain family member 1 (SV40 transcriptional enhancer factor) C00018055
7015 TERT, CMM9, DKCA2, DKCB4, EST2, PFBMFT1, TCS1, TP2, TRT, hEST2, hTRT telomerase reverse transcriptase (EC:2.7.7.49) C00018055
7040 TGFB1, CED, DPD1, LAP, TGFB, TGFbeta transforming growth factor, beta 1 C00018055
8914 TIMELESS, TIM, TIM1, hTIM timeless circadian clock C00018055
7078 TIMP3, HSMRK222, K222, K222TA2, SFD TIMP metallopeptidase inhibitor 3 C00018055
51522 TMEM14C, C6orf53, MSTP073, NET26, bA421M1.6 transmembrane protein 14C C00018055
7124 TNF, DIF, TNF-alpha, TNFA, TNFSF2 tumor necrosis factor C00018055
7157 TP53, BCC7, LFS1, P53, TRP53 tumor protein p53 C00018055
8626 TP63, AIS, B(p51A), B(p51B), EEC3, KET, LMS, NBP, OFC8, RHS, SHFM4, TP53CP, TP53L, TP73L, p40, p51, p53CP, p63, p73H, p73L tumor protein p63 C00018055
7161 TP73, P73 tumor protein p73 C00018055
7272 TTK, CT96, ESK, MPH1, MPS1, MPS1L1, PYT TTK protein kinase (EC:2.7.12.1) C00018055
7298 TYMS, HST422, TMS, TS thymidylate synthetase (EC:2.1.1.45) C00018055
8725 URI1, C19orf2, NNX3, PPP1R19, RMP, URI URI1, prefoldin-like chaperone C00018055
7422 VEGFA, MVCD1, VEGF, VPF vascular endothelial growth factor A C00018055
7490 WT1, AWT1, EWS-WT1, GUD, NPHS4, WAGR, WIT-2, WT33 Wilms tumor 1 C00018055
7494 XBP1, TREB5, XBP-1, XBP2 X-box binding protein 1 C00018055
331 XIAP, API3, BIRC4, IAP-3, ILP1, MIHA, XLP2, hIAP-3, hIAP3 X-linked inhibitor of apoptosis C00018055
29799 YPEL1 yippee-like 1 (Drosophila) C00018055
7546 ZIC2, HPE5 Zic family member 2 C00018055
30834 ZNRD1, HTEX-6, Rpa12, TEX6, ZR14, hZR14, tctex-6 zinc ribbon domain containing 1 (EC:2.7.7.6) C00018055
11130 ZWINT, HZwint-1, KNTC2AP, ZWINT1 ZW10 interacting kinetochore protein C00018055

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (180)

OMIM preferred title UniProt
#100100 Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism P20309
#100800 Achondroplasia; ach P22607
#615224 Advanced sleep phase syndrome, familial, 2; fasps2 P48730
#300755 Agammaglobulinemia, x-linked; xla Q06187
#103780 Alcohol dependence P08172
P14416
P31645
#614373 Amyotrophic lateral sclerosis 16, juvenile; als16 Q99720
#207410 Antley-bixler syndrome without genital anomalies or disordered steroidogenesis; abs2 P21802
#613780 Aortic aneurysm, familial thoracic 7; aat7 Q15746
#101200 Apert syndrome P21802
#615091 Autism, susceptibility to, 19; auts19 P06730
#615007 Basal ganglia calcification, idiopathic, 4; ibgc4 P09619
#123790 Beare-stevenson cutis gyrata syndrome; bstvs P21802
#614592 Bent bone dysplasia syndrome; bbds P21802
#109800 Bladder cancer P22607
#602025 Body mass index quantitative trait locus 9; bmiq9 P41968
#114480 Breast cancer O96017
P31749
#300615 Brunner syndrome P21397
#600880 Budd-chiari syndrome; bdchs O60674
#610474 Camptodactyly, tall stature, and hearing loss syndrome P22607
#615279 Cardiofaciocutaneous syndrome 3; cfc3 Q02750
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#600858 Cardiomyopathy, familial hypertrophic, 6; cmh6 Q9UGJ0
#116600 Cataract 6, multiple types; ctrct6 P29317
#209880 Central hypoventilation syndrome, congenital; cchs P07949
#603956 Cervical cancer P22607
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#613630 Cocoon syndrome O15111
#303600 Coffin-lowry syndrome; cls P51812
#114500 Colorectal cancer; crc P07949
P29320
P31749
P84022
#615109 Cowden syndrome 6; cws6 P31749
#123500 Crouzon syndrome P21802
#612247 Crouzon syndrome with acanthosis nigricans; can P22607
#162800 Cyclic neutropenia P08246
#127750 Dementia, lewy body; dlb P37840
#612522 Diabetes mellitus, insulin-dependent, 22; iddm22 P51681
#610549 Diabetes mellitus, insulin-resistant, with acanthosis nigricans P06213
#125853 Diabetes mellitus, noninsulin-dependent; niddm P06213
P31751
#246200 Donohue syndrome P06213
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#615363 Estrogen resistance; estrr P03372
#600274 Frontotemporal dementia; ftd P10636
#613659 Gastric cancer P04626
#137215 Gastric cancer, hereditary diffuse; hdgc P04626
#606764 Gastrointestinal stromal tumor; gist P10721
P16234
#231095 Ghosal hematodiaphyseal dysplasia; ghdd P24557
#177700 Glaucoma 1, open angle, p; glc1p Q9UHD2
#137800 Glioma susceptibility 1; glm1 P04626
#613027 Glycogen storage disease ixc; gsd9c P15735
#261740 Glycogen storage disease of heart, lethal congenital Q9UGJ0
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#602089 Hemangioma, capillary infantile P35916
P35968
#114550 Hepatocellular carcinoma P08581
#142623 Hirschsprung disease, susceptibility to, 1; hscr1 P07949
#609423 Human immunodeficiency virus type 1, susceptibility to P41597
P51681
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#237450 Hyperbilirubinemia, rotor type; hblrr Q9Y6L6
#607685 Hypereosinophilic syndrome, idiopathic; hes P16234
#602485 Hyperinsulinemic hypoglycemia, familial, 3; hhf3 P35557
#609968 Hyperinsulinemic hypoglycemia, familial, 5; hhf5 P06213
#145000 Hyperparathyroidism 1; hrpt1 O00255
#146000 Hypochondroplasia; hch P22607
#147950 Hypogonadotropic hypogonadism 2 with or without anosmia; hh2 P11362
#240900 Hypoinsulinemic hypoglycemia with hemihypertrophy; hihghh P31751
#612244 Inflammatory bowel disease 13; ibd13 P08183
#256800 Insensitivity to pain, congenital, with anhidrosis; cipa P04629
#270450 Insulin-like growth factor i, resistance to P08069
#603932 Intervertebral disc disease; idd P14780
#610799 Invasive pneumococcal disease, recurrent isolated, 1; ipd1 Q9NWZ3
#607676 Irak4 deficiency Q9NWZ3
#307200 Isolated growth hormone deficiency, type iii; ighd3 Q06187
#123150 Jackson-weiss syndrome; jws P21802
#607785 Juvenile myelomonocytic leukemia; jmml P09619
#182000 Keratosis, seborrheic P22607
#149730 Lacrimoauriculodentodigital syndrome; ladd P21802
P22607
#611554 Leopard syndrome 2 P04049
#601626 Leukemia, acute myeloid; aml O60674
P09619
P10721
P36888
#608232 Leukemia, chronic myeloid; cml P00519
#221820 Leukoencephalopathy, diffuse hereditary, with spheroids; hdls P07333
#609265 Li-fraumeni syndrome 2; lfs2 O96017
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#609192 Loeys-dietz syndrome, type 1a; lds1a P36897
#608967 Loeys-dietz syndrome, type 2a; lds2a P36897
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#613688 Long qt syndrome 2; lqt2 Q12809
#211980 Lung cancer P00533
P04626
#153100 Lymphedema, hereditary, ia P35916
#613011 Lymphoproliferative syndrome 1; lpfs1 Q08881
#608516 Major depressive disorder; mdd P08172
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#613375 Maturity-onset diabetes of the young, type 11; mody11 P51451
#125851 Maturity-onset diabetes of the young, type 2; mody2 P35557
#606391 Maturity-onset diabetes of the young; mody P35557
#603387 Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome; mpph Q9Y243
#614104 Mental retardation, autosomal dominant 7; mrd7 Q13627
#300844 Mental retardation, x-linked 19; mrx19 P51812
#300558 Mental retardation, x-linked 30; mrx30 O75914
%300852 Mental retardation, x-linked 88; mrx88 P50052
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#602849 Muenke syndrome; mnkes P22607
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#171400 Multiple endocrine neoplasia, type iia; men2a P07949
#162300 Multiple endocrine neoplasia, type iib; men2b P07949
#126200 Multiple sclerosis, susceptibility to; ms P08575
#132800 Multiple self-healing squamous epithelioma, susceptibility to; msse P36897
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#608931 Myasthenic syndrome, congenital, associated with acetylcholine receptor deficiency O15146
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#254450 Myelofibrosis O60674
#254500 Myeloma, multiple P22607
#131440 Myeloproliferative disorder, chronic, with eosinophilia P09619
#159900 Myoclonic dystonia P14416
#228550 Myofibromatosis, infantile, 1; imf1 P09619
#160900 Myotonic dystrophy 1; dm1 Q09013
#613014 Neuroblastoma, susceptibility to, 3; nblst3 Q9UM73
#202700 Neutropenia, severe congenital, 1, autosomal dominant; scn1 P08246
#162900 Nevus, epidermal P22607
#611553 Noonan syndrome 5; ns5 P04049
#601665 Obesity P32245
#613886 Obesity, hyperphagia, and developmental delay Q16620
#164230 Obsessive-compulsive disorder; ocd P31645
#604715 Orthostatic intolerance P23975
#259500 Osteogenic sarcoma O96017
#166250 Osteoglophonic dysplasia; ogd P11362
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#167000 Ovarian cancer P04626
#168601 Parkinson disease 1, autosomal dominant; park1 P37840
#605543 Parkinson disease 4, autosomal dominant; park4 P37840
#168600 Parkinson disease, late-onset; pd P37840
#260540 Parkinson-dementia syndrome P10636
#613135 Parkinsonism-dystonia, infantile; pkdys Q01959
#175200 Peutz-jeghers syndrome; pjs Q15831
#101600 Pfeiffer syndrome P11362
P21802
#171300 Pheochromocytoma P07949
#172700 Pick disease of brain P10636
#172800 Piebald trait; pbt P10721
#262190 Pineal hyperplasia, insulin-resistant diabetes mellitus, and somatic abnormalities P06213
#263300 Polycythemia vera; pv O60674
#176807 Prostate cancer O96017
P29323
#603688 Prostate cancer/brain cancer susceptibility P29323
#176920 Proteus syndrome P31749
#191830 Renal adysplasia P07949
#605074 Renal cell carcinoma, papillary, 1; rccp1 P08581
#607276 Resting heart rate, variation in P08588
#275210 Restrictive dermopathy, lethal P02545
#613862 Retinitis pigmentosa 38; rp38 Q12866
#609579 Scaphocephaly, maxillary retrusion, and mental retardation P21802
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#269840 Selective t-cell defect; stcd P43403
#600802 Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-negative P52333
#608971 Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive P08575
#609620 Short qt syndrome 1; sqt1 Q12809
#243060 Spermatogenic failure 5; spgf5 Q9UQB9
#605361 Spinocerebellar ataxia 14; sca14 P05129
#271665 Spondylometaepiphyseal dysplasia, short limb-hand type Q16832
%612223 Stature quantitative trait locus 11; stqtl11 Q00534
#601367 Stroke, ischemic P24723
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#614868 T-cell immunodeficiency, recurrent infections, and autoimmunity with or without cardiac malformations; tiiac Q13043
#273300 Testicular germ cell tumor; tgct O94804
P10721
P22607
Q15831
#187600 Thanatophoric dysplasia, type i; td1 P22607
#187601 Thanatophoric dysplasia, type ii; td2 P22607
#614521 Thrombocythemia 3; thcyt3 O60674
#155240 Thyroid carcinoma, familial medullary; mtc P07949
#188550 Thyroid carcinoma, papillary P04629
P07949
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828
#190300 Tremor, hereditary essential, 1; etm1 P35462
#190440 Trigonocephaly 1; trigno1 P11362
#600195 Venous malformations, multiple cutaneous and mucosal; vmcm Q02763
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473
#610379 West nile virus, susceptibility to P51681
#194200 Wolff-parkinson-white syndrome Q9UGJ0
#112100 Yt blood group antigen P22303

KEGG DISEASE (115)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00882 Cocoon syndrome O15111 (related)
H00770 Congenital myasthenic syndrome O15146 (related)
H00012 Polycythemia vera O60674 (related)
O60674 (marker)
H00480 Non-syndromic X-linked mental retardation O75914 (related)
P50052 (related)
P51812 (related)
H00881 Li-Fraumeni syndrome O96017 (related)
H00018 Gastric cancer O96020 (related)
P00533 (related)
P04626 (related)
P08581 (related)
P21802 (related)
P24864 (related)
H00055 Laryngeal cancer O96020 (related)
P00533 (related)
P00533 (marker)
P24864 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) P00519 (related)
P00519 (marker)
Q03164 (related)
Q03164 (marker)
H00004 Chronic myeloid leukemia (CML) P00519 (related)
P00519 (marker)
H00016 Oral cancer P00533 (related)
P00533 (marker)
H00017 Esophageal cancer P00533 (related)
P35354 (related)
H00022 Bladder cancer P00533 (related)
P04626 (related)
P22607 (related)
P53355 (related)
H00028 Choriocarcinoma P00533 (related)
P03956 (related)
P04626 (related)
P07333 (related)
H00030 Cervical cancer P00533 (related)
P04626 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
P09619 (related)
P16234 (related)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
P31751 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00026 Endometrial Cancer P03372 (marker)
P04626 (related)
Q92731 (marker)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00019 Pancreatic cancer P04626 (related)
Q15831 (related)
H00027 Ovarian cancer P04626 (related)
P31751 (related)
H00031 Breast cancer P04626 (related)
P04626 (marker)
H00046 Cholangiocarcinoma P04626 (related)
P08581 (related)
P35354 (related)
H00032 Thyroid cancer P04629 (related)
P07949 (related)
P07949 (marker)
H00043 Neuroblastoma P04629 (related)
P04629 (marker)
Q16620 (related)
H00265 Hereditary sensory and autonomic neuropathy (HSAN) P04629 (related)
H00063 Spinocerebellar ataxia (SCA) P05129 (related)
H00719 Leprechaunism P06213 (related)
H00942 Rabson-Mendenhall syndrome P06213 (related)
H01228 Insulin-resistant diabetes mellitus with acanthosis nigricans (IRAN) P06213 (related)
H01267 Familial hyperinsulinemic hypoglycemia (HHF) P06213 (related)
P35557 (related)
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
P43403 (related)
H00079 Asthma P07550 (related)
H00822 Renal agenesis and Renal adysplasia P07949 (related)
H00910 Hirschsprung disease (HD) P07949 (related)
H00916 Congenital central hypoventilation syndrome (CCHS) P07949 (related)
H00015 Malignant pleural mesothelioma P08069 (related)
H00050 Synovial sarcoma P08069 (related)
H01274 Growth delay due to insulin-like growth factor I resistance P08069 (related)
H00100 Neutropenic disorders P08246 (related)
H00091 T-B+Severe combined immunodeficiencies (SCIDs) P08575 (related)
P52333 (related)
H00021 Renal cell carcinoma P08581 (related)
H00036 Osteosarcoma P08684 (marker)
H00014 Non-small cell lung cancer P08922 (related)
Q9UM73 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00003 Acute myeloid leukemia (AML) P10721 (related)
P10721 (marker)
P36888 (related)
H00170 Piebaldism P10721 (related)
H00023 Testicular cancer P10721 (marker)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H00255 Hypogonadotropic hypogonadism P11362 (related)
H00443 Osteoglophonic dysplasia (OD) P11362 (related)
H00458 Craniosynostosis P11362 (related)
P21802 (related)
P22607 (related)
H00516 Isolated orofacial clefts P11362 (related)
H01207 Trigonocephaly P11362 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H01205 Coumarin resistance P11712 (related)
H00025 Penile cancer P14780 (related)
P35354 (related)
H00479 Metaphyseal dysplasias P14780 (related)
H00069 Glycogen storage diseases (GSD) P15735 (related)
Q9UGJ0 (related)
H00548 Brunner syndrome P21397 (related)
H00642 Lacrimo-auriculo-dento-digital syndrome (LADD) P21802 (related)
P22607 (related)
H00010 Multiple myeloma P22607 (related)
P30281 (related)
H00505 FGFR3-related short limb skeletal dysplasias P22607 (related)
H00997 CATSHL syndrome P22607 (related)
H01031 Orthostatic intolerance (OI) P23975 (related)
H00490 Diaphyseal dysplasia with anemia (Ghosal) P24557 (related)
H01202 Cataract P29317 (related)
H00539 PTEN hamartoma tumor syndrome (PHTS) P31749 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00410 Maturity onset diabetes of the young (MODY) P35557 (related)
P51451 (related)
H00512 Permanent neonatal diabetes mellitus (PNDM) P35557 (related)
H00535 Lymphedemas P35916 (related)
H00800 Loeys-Dietz syndrome (LDS) P36897 (related)
H00801 Familial thoracic aortic aneurysm and dissection (TAAD) P36897 (related)
Q15746 (related)
H00057 Parkinson's disease (PD) P37840 (related)
H00066 Lewy body dementia (LBD) P37840 (related)
H00005 Chronic lymphocytic leukemia (CLL) P43403 (marker)
H00574 Coffin-Lowry syndrome (CLS) P51812 (related)
H00606 Early infantile epileptic encephalopathy P53779 (related)
H00523 Noonan syndrome and related disorders Q02750 (related)
H00531 Venous malformations Q02763 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00408 Type I diabetes mellitus Q04759 (related)
H00085 Agammaglobulinemias Q06187 (related)
H00254 Pituitary Dwarfism (PD) Q06187 (related)
H00107 Other well-defined immunodeficiency syndromes Q08881 (related)
H00568 Myotonic dystrophy (DM) Q09013 (related)
H00720 Long QT syndrome Q12809 (related)
H00725 Short QT syndrome Q12809 (related)
H00527 Retinitis pigmentosa (RP) Q12866 (related)
H00666 Peutz-Jeghers syndrome Q15831 (related)
H00777 Spondylometaepiphyseal dysplasia, short limb-hand type Q16832 (related)
H00096 Defects of toll-like receptor signaling Q9NWZ3 (related)
H00292 Hypertrophic cardiomyopathy (HCM) Q9UGJ0 (related)
H01154 Wolff-Parkinson-White (WPW) syndrome Q9UGJ0 (related)
H01282 Spermatogenic failure Q9UQB9 (related)

Diseases related to CTD interactions

110 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D007674 Kidney Diseases C00017631
C00018055
D010300 Parkinson Disease C00018055
D012640 Seizures C00017631
D058186 Acute Kidney Injury C00018055
D000419 Albuminuria C00018055
D000740 Anemia C00018055
D000799 Angioedema C00018055
D050197 Atherosclerosis C00018055
D001321 Autistic Disorder C00018055
D001927 Brain Diseases C00018055
D020520 Brain Infarction C00018055
D019559 Capillary Leak Syndrome C00018055
D002277 Carcinoma C00018055
D006528 Carcinoma, Hepatocellular C00018055
D002294 Carcinoma, Squamous Cell C00018055
D002305 Cardiac Tamponade C00018055
D006332 Cardiomegaly C00018055
D020212 Carotid Artery Injuries C00018055
D002779 Cholestasis C00018055
D003251 Constriction, Pathologic C00018055
D023903 Coronary Restenosis C00018055
D003329 Coronary Vasospasm C00018055
D016757 Death, Sudden, Cardiac C00018055
D051799 Delayed Graft Function C00018055
D003711 Demyelinating Diseases C00018055
D003873 Dermatitis, Exfoliative C00018055
D003928 Diabetic Nephropathies C00018055
D003967 Diarrhea C00018055
D003875 Drug Eruptions C00018055
D004487 Edema C00018055
D005076 Exanthema C00018055
D005334 Fever C00018055
D005549 Foreign-Body Reaction C00018055
D015432 Glomerulonephritis, Membranoproliferative C00018055
D015433 Glomerulonephritis, Membranous C00018055
D005923 Glomerulosclerosis, Focal Segmental C00018055
D018149 Glucose Intolerance C00018055
D006086 Graft vs Host Disease C00018055
D006258 Head and Neck Neoplasms C00018055
D006463 Hemolytic-Uremic Syndrome C00018055
D006504 Hepatic Veno-Occlusive Disease C00018055
D006816 Huntington Disease C00018055
D006937 Hypercholesterolemia C00018055
D006943 Hyperglycemia C00018055
D006947 Hyperkalemia C00018055
D006949 Hyperlipidemias C00018055
D006965 Hyperplasia C00018055
D006973 Hypertension C00018055
D015228 Hypertriglyceridemia C00018055
D006984 Hypertrophy C00018055
D033461 Hyperuricemia C00018055
D007008 Hypokalemia C00018055
D007239 Infection C00018055
D007249 Inflammation C00018055
D007683 Kidney Tubular Necrosis, Acute C00018055
D015451 Leukemia, Lymphocytic, Chronic, B-Cell C00018055
D007970 Leukopenia C00018055
D008103 Liver Cirrhosis C00018055
D008106 Liver Cirrhosis, Experimental C00018055
D017563 Lung Diseases, Interstitial C00018055
D008209 Lymphedema C00018055
D008210 Lymphocele C00018055
D016403 Lymphoma, Large B-Cell, Diffuse C00018055
D008275 Magnesium Deficiency C00018055
D008545 Melanoma C00018055
D008546 Melanoma, Experimental C00018055
D008654 Mesothelioma C00018055
D017566 Microvascular Angina C00018055
D009062 Mouth Neoplasms C00018055
D009101 Multiple Myeloma C00018055
D009135 Muscular Diseases C00018055
D009203 Myocardial Infarction C00018055
D058426 Neointima C00018055
D009361 Neoplasm Invasiveness C00018055
D009362 Neoplasm Metastasis C00018055
D009369 Neoplasms C00018055
D009374 Neoplasms, Experimental C00018055
D009389 Neovascularization, Pathologic C00018055
D009397 Nephrocalcinosis C00018055
D009404 Nephrotic Syndrome C00018055
D009845 Oligospermia C00018055
D019226 Oral Ulcer C00018055
D007035 Hypothermia C00017631
D010850 Picornaviridae Infections C00018055
D011014 Pneumonia C00018055
D016891 Polycystic Kidney, Autosomal Dominant C00018055
D007690 Polycystic Kidney Diseases C00018055
D011115 Polyneuropathies C00018055
D011183 Postoperative Complications C00018055
D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma C00018055
D054218 Precursor T-Cell Lymphoblastic Leukemia-Lymphoma C00018055
D017096 Prion Diseases C00018055
D011507 Proteinuria C00018055
D011565 Psoriasis C00018055
D012019 Reflex Sympathetic Dystrophy C00018055
D015427 Reperfusion Injury C00018055
D012206 Rhabdomyolysis C00018055
D012878 Skin Neoplasms C00018055
D013281 Stomatitis, Aphthous C00018055
D013529 Surgical Wound Dehiscence C00018055
D013921 Thrombocytopenia C00018055
D013927 Thrombosis C00018055
D057049 Thrombotic Microangiopathies C00018055
D014402 Tuberous Sclerosis C00018055
D014456 Ulcer C00018055
D014605 Uveitis C00018055
D018366 Vasculitis, Leukocytoclastic, Cutaneous C00018055
D018754 Ventricular Dysfunction C00018055
D015430 Weight Gain C00018055
D015431 Weight Loss C00018055