PCIDB

KNApSAcK Metabolite C00001789

Metabolite

KNApSAcK Entry

id C00001789
Name Yohimbine
CAS RN 146-48-5
Standard InChI InChI=1S/C21H26N2O3/c1-26-21(25)19-15-10-17-20-14(13-4-2-3-5-16(13)22-20)8-9-23(17)11-12(15)6-7-18(19)24/h2-5,12,15,17-19,22,24H,6-11H2,1H3/t12-,15-,17-,18-,19+/m0/s1
Standard InChI (Main Layer) InChI=1S/C21H26N2O3/c1-26-21(25)19-15-10-17-20-14(13-4-2-3-5-16(13)22-20)8-9-23(17)11-12(15)6-7-18(19)24/h2-5,12,15,17-19,22,24H,6-11H2,1H3

Cluster

Phytochemical cluster No. 4
KCF-S cluster No. 229

Link

ChEMBL

By standard InChI CHEMBL15245
By standard InChI Main Layer CHEMBL10347 CHEMBL15245 CHEMBL31410 CHEMBL196400 CHEMBL465600 CHEMBL1327758 CHEMBL1472740 CHEMBL1473950 CHEMBL1475803 CHEMBL1514351 CHEMBL1526082 CHEMBL1531132 CHEMBL1625779 CHEMBL2079555

KEGG

By LinkDB C09256

CTD

By CAS RN D015016

Human Protein / Gene in interaction

130 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 CHEMBL15245 CHEMBL31410 CHEMBL1327758 CHEMBL1514351 CHEMBL2079555 CHEMBL729201 (1) CHEMBL729203 (1)
CHEMBL729204 (1) CHEMBL729205 (1)
CHEMBL729206 (3) CHEMBL758056 (1)
CHEMBL828928 (1) CHEMBL827154 (1)
CHEMBL1614110 (11) CHEMBL1741321 (9)
CHEMBL1909136 (2)
1 / 0
P42345 Serine/threonine-protein kinase mTOR Enzyme CHEMBL15245 CHEMBL1613805 (1)
0 / 0
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein CHEMBL31410 CHEMBL1531132 CHEMBL1738312 (2)
0 / 0
Q99700 Ataxin-2 Unclassified protein CHEMBL15245 CHEMBL1794367 (1)
1 / 1
P49798 Regulator of G-protein signaling 4 Unclassified protein CHEMBL10347 CHEMBL15245 CHEMBL31410 CHEMBL1794499 (3)
2 / 0
P21728 D(1A) dopamine receptor Dopamine receptor CHEMBL15245 CHEMBL1738091 (1) CHEMBL1738565 (1)
CHEMBL1909139 (2)
0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase CHEMBL15245 CHEMBL1909131 (2)
0 / 3
Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH, Kv10-12.x (Ether-a-go-go) CHEMBL15245 CHEMBL1909190 (2)
2 / 2
P08246 Neutrophil elastase S1A CHEMBL15245 CHEMBL1909195 (2)
2 / 1
P33765 Adenosine receptor A3 Adenosine receptor CHEMBL15245 CHEMBL881969 (1) CHEMBL1909215 (2)
0 / 0
Q16539 Mitogen-activated protein kinase 14 p38 CHEMBL15245 CHEMBL1909201 (2)
0 / 0
P49146 Neuropeptide Y receptor type 2 Neuropeptide Y receptor CHEMBL15245 CHEMBL1909176 (2)
0 / 0
P04062 Glucosylceramidase Enzyme CHEMBL1472740 CHEMBL1613818 (1)
6 / 4
P29466 Caspase-1 C14 CHEMBL15245 CHEMBL1909193 (2)
0 / 0
P17252 Protein kinase C alpha type Alpha CHEMBL15245 CHEMBL1909198 (2)
0 / 0
P27361 Mitogen-activated protein kinase 3 Erk CHEMBL15245 CHEMBL1909199 (2)
0 / 0
P14780 Matrix metalloproteinase-9 M10A CHEMBL15245 CHEMBL1909197 (2)
2 / 2
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme CHEMBL15245 CHEMBL31410 CHEMBL1531132 CHEMBL1794585 (3)
0 / 0
P02545 Prelamin-A/C Unclassified protein CHEMBL31410 CHEMBL1327758 CHEMBL1614544 (4)
11 / 10
P16473 Thyrotropin receptor Glycohormone receptor CHEMBL31410 CHEMBL1327758 CHEMBL1614281 (1) CHEMBL1614361 (3)
3 / 2
P10828 Thyroid hormone receptor beta NR1A2 CHEMBL1472740 CHEMBL1613776 (1)
3 / 1
P00918 Carbonic anhydrase 2 Lyase CHEMBL15245 CHEMBL1909123 (2)
1 / 2
P07550 Beta-2 adrenergic receptor Adrenergic receptor CHEMBL15245 CHEMBL1909092 (2)
0 / 1
P21397 Amine oxidase [flavin-containing] A Oxidoreductase CHEMBL15245 CHEMBL1909169 (2)
1 / 1
P25021 Histamine H2 receptor Histamine receptor CHEMBL15245 CHEMBL1909157 (2)
0 / 0
P35367 Histamine H1 receptor Histamine receptor CHEMBL15245 CHEMBL1909156 (2)
0 / 0
Q01959 Sodium-dependent dopamine transporter Dopamine CHEMBL15245 CHEMBL1909143 (2)
1 / 0
P08912 Muscarinic acetylcholine receptor M5 Acetylcholine receptor CHEMBL15245 CHEMBL1909174 (2)
0 / 0
P18825 Alpha-2C adrenergic receptor Adrenergic receptor CHEMBL10347 CHEMBL15245 CHEMBL31410 CHEMBL196400 CHEMBL644360 (1) CHEMBL644361 (1)
CHEMBL644362 (2) CHEMBL644363 (2)
CHEMBL644364 (2) CHEMBL644527 (4)
CHEMBL644528 (4) CHEMBL644529 (4)
CHEMBL644530 (4) CHEMBL641047 (1)
CHEMBL641385 (1) CHEMBL642214 (1)
CHEMBL645606 (1) CHEMBL645613 (1)
CHEMBL646110 (1) CHEMBL649186 (1)
CHEMBL649187 (1) CHEMBL649188 (1)
CHEMBL649189 (1) CHEMBL649190 (1)
CHEMBL649191 (1) CHEMBL649192 (1)
CHEMBL649193 (1) CHEMBL649194 (1)
CHEMBL649195 (1) CHEMBL873171 (1)
CHEMBL649196 (1) CHEMBL875438 (1)
CHEMBL649197 (1) CHEMBL648623 (3)
CHEMBL648085 (1) CHEMBL648086 (1)
CHEMBL647414 (1) CHEMBL768015 (3)
CHEMBL822824 (1) CHEMBL843759 (1)
CHEMBL829301 (1) CHEMBL1909090 (2)
0 / 0
P13945 Beta-3 adrenergic receptor Adrenergic receptor CHEMBL15245 CHEMBL1909093 (2)
0 / 0
P08183 Multidrug resistance protein 1 drug CHEMBL15245 CHEMBL1908285 (1) CHEMBL1908286 (1)
CHEMBL1908289 (1) CHEMBL1908291 (1)
CHEMBL1908292 (1)
1 / 0
P25024 C-X-C chemokine receptor type 1 CXC chemokine receptor CHEMBL15245 CHEMBL1909127 (2)
0 / 0
P06241 Tyrosine-protein kinase Fyn Src CHEMBL15245 CHEMBL1909204 (2)
0 / 0
Q08209 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform Ser_Thr CHEMBL15245 CHEMBL1909202 (2)
0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 CHEMBL15245 CHEMBL31410 CHEMBL1327758 CHEMBL1514351 CHEMBL1614027 (2) CHEMBL1741325 (9)
CHEMBL1909135 (2)
0 / 1
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily CHEMBL15245 CHEMBL1909203 (2)
1 / 11
P11387 DNA topoisomerase 1 Isomerase CHEMBL15245 CHEMBL465600 CHEMBL1003401 (3)
0 / 0
P11473 Vitamin D3 receptor NR1I1 CHEMBL1472740 CHEMBL1794311 (1)
2 / 3
P14416 D(2) dopamine receptor Dopamine receptor CHEMBL15245 CHEMBL1909140 (2)
2 / 0
P23219 Prostaglandin G/H synthase 1 Oxidoreductase CHEMBL15245 CHEMBL1909130 (2)
0 / 0
P37288 Vasopressin V1a receptor Vasopressin and oxytocin receptor CHEMBL15245 CHEMBL1909120 (2)
0 / 0
P41145 Kappa-type opioid receptor Opioid receptor CHEMBL15245 CHEMBL1909181 (2)
0 / 0
Q9Y271 Cysteinyl leukotriene receptor 1 Leukotriene receptor CHEMBL15245 CHEMBL1909164 (2)
0 / 0
P29274 Adenosine receptor A2a Adenosine receptor CHEMBL15245 CHEMBL1909214 (2)
0 / 0
P25929 Neuropeptide Y receptor type 1 Neuropeptide Y receptor CHEMBL15245 CHEMBL1909175 (2)
0 / 0
P50052 Type-2 angiotensin II receptor Angiotensin receptor CHEMBL15245 CHEMBL1909096 (2)
1 / 1
P17948 Vascular endothelial growth factor receptor 1 Vegfr CHEMBL15245 CHEMBL1909118 (2)
0 / 0
P41968 Melanocortin receptor 3 Melanocortin receptor CHEMBL15245 CHEMBL1909166 (2)
1 / 0
P00352 Retinal dehydrogenase 1 Enzyme CHEMBL31410 CHEMBL1472740 CHEMBL1614458 (2)
0 / 0
P17405 Sphingomyelin phosphodiesterase Enzyme CHEMBL31410 CHEMBL1531132 CHEMBL1794495 (2)
2 / 2
P11509 Cytochrome P450 2A6 Cytochrome P450 2A6 CHEMBL15245 CHEMBL1909133 (2)
0 / 0
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor CHEMBL31410 CHEMBL1614456 (1) CHEMBL1613803 (1)
0 / 0
P39748 Flap endonuclease 1 Enzyme CHEMBL10347 CHEMBL31410 CHEMBL1794486 (2)
0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme CHEMBL15245 CHEMBL1738606 (1)
0 / 0
O75496 Geminin Unclassified protein CHEMBL31410 CHEMBL2114780 (1)
0 / 0
P04035 3-hydroxy-3-methylglutaryl-coenzyme A reductase Oxidoreductase CHEMBL15245 CHEMBL1909158 (2)
0 / 0
P08913 Alpha-2A adrenergic receptor Adrenergic receptor CHEMBL10347 CHEMBL15245 CHEMBL31410 CHEMBL196400 CHEMBL644360 (1) CHEMBL644361 (1)
CHEMBL644362 (2) CHEMBL644363 (2)
CHEMBL644364 (2) CHEMBL644527 (4)
CHEMBL644528 (4) CHEMBL644529 (4)
CHEMBL644530 (4) CHEMBL647963 (1)
CHEMBL647721 (3) CHEMBL647725 (1)
CHEMBL641047 (1) CHEMBL641385 (1)
CHEMBL642214 (1) CHEMBL645606 (1)
CHEMBL645613 (1) CHEMBL646110 (1)
CHEMBL649186 (1) CHEMBL649187 (1)
CHEMBL649188 (1) CHEMBL649189 (1)
CHEMBL649190 (1) CHEMBL649191 (1)
CHEMBL649192 (1) CHEMBL649193 (1)
CHEMBL649194 (1) CHEMBL649195 (1)
CHEMBL873171 (1) CHEMBL649196 (1)
CHEMBL875438 (1) CHEMBL649197 (1)
CHEMBL648085 (1) CHEMBL648086 (1)
CHEMBL647414 (1) CHEMBL768015 (3)
CHEMBL822824 (1) CHEMBL843759 (1)
CHEMBL839549 (1) CHEMBL972062 (1)
CHEMBL1226896 (2) CHEMBL1227024 (1)
CHEMBL1228582 (1) CHEMBL1228583 (1)
CHEMBL1228584 (2) CHEMBL1909088 (2)
0 / 0
P21917 D(4) dopamine receptor Dopamine receptor CHEMBL15245 CHEMBL1909142 (2)
0 / 0
P30988 Calcitonin receptor Calcitonin receptor CHEMBL15245 CHEMBL1909101 (2)
0 / 0
P35348 Alpha-1A adrenergic receptor Adrenergic receptor CHEMBL10347 CHEMBL15245 CHEMBL31410 CHEMBL647014 (1) CHEMBL648807 (1)
CHEMBL647810 (2) CHEMBL647813 (1)
CHEMBL647045 (3) CHEMBL772607 (1)
CHEMBL815329 (1) CHEMBL840159 (1)
0 / 0
P35462 D(3) dopamine receptor Dopamine receptor CHEMBL15245 CHEMBL1909141 (2)
1 / 0
P41143 Delta-type opioid receptor Opioid receptor CHEMBL15245 CHEMBL1909180 (2)
0 / 0
Q92731 Estrogen receptor beta NR3A2 CHEMBL15245 CHEMBL1909146 (2)
0 / 1
P41595 5-hydroxytryptamine receptor 2B Serotonin receptor CHEMBL15245 CHEMBL850007 (1) CHEMBL1909104 (2)
0 / 0
P25101 Endothelin-1 receptor Endothelin receptor CHEMBL15245 CHEMBL1909144 (2)
0 / 0
P30411 B2 bradykinin receptor Bradykinin receptor CHEMBL15245 CHEMBL1909100 (2)
0 / 0
P32245 Melanocortin receptor 4 Melanocortin receptor CHEMBL15245 CHEMBL1909167 (2)
1 / 0
P32238 Cholecystokinin receptor type A Cholecystokinin receptor CHEMBL15245 CHEMBL1909129 (2)
0 / 0
P08311 Cathepsin G S1A CHEMBL15245 CHEMBL1909194 (2)
0 / 0
Q99720 Sigma non-opioid intracellular receptor 1 Membrane receptor CHEMBL15245 CHEMBL1909110 (2)
1 / 0
P03956 Interstitial collagenase M10A CHEMBL15245 CHEMBL1909196 (2)
0 / 1
P32241 Vasoactive intestinal polypeptide receptor 1 Vasoactive intestinal peptide receptor CHEMBL15245 CHEMBL1909119 (2)
0 / 0
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein CHEMBL1531132 CHEMBL2114810 (1)
7 / 3
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme CHEMBL1472740 CHEMBL1794467 (1)
0 / 0
P04150 Glucocorticoid receptor NR3C1 CHEMBL15245 CHEMBL1909150 (2)
0 / 1
P08172 Muscarinic acetylcholine receptor M2 Acetylcholine receptor CHEMBL15245 CHEMBL1909171 (2)
2 / 0
P11229 Muscarinic acetylcholine receptor M1 Acetylcholine receptor CHEMBL15245 CHEMBL1909170 (2)
0 / 0
P21554 Cannabinoid receptor 1 Cannabinoid receptor CHEMBL15245 CHEMBL1909122 (2)
0 / 0
P31645 Sodium-dependent serotonin transporter Serotonin CHEMBL15245 CHEMBL1909109 (2)
2 / 0
P04626 Receptor tyrosine-protein kinase erbB-2 TK tyrosine-protein kinase EGFR subfamily CHEMBL15245 CHEMBL1909205 (2)
5 / 10
P20309 Muscarinic acetylcholine receptor M3 Acetylcholine receptor CHEMBL15245 CHEMBL1909172 (2)
1 / 0
P21452 Substance-K receptor Neurokinin receptor CHEMBL15245 CHEMBL1909114 (2)
0 / 0
P30304 M-phase inducer phosphatase 1 Ser_Thr_Tyr CHEMBL15245 CHEMBL2157130 (1)
0 / 0
P51679 C-C chemokine receptor type 4 CC chemokine receptor CHEMBL15245 CHEMBL1909125 (2)
0 / 0
P51681 C-C chemokine receptor type 5 CC chemokine receptor CHEMBL15245 CHEMBL1909126 (2)
3 / 0
P50406 5-hydroxytryptamine receptor 6 Serotonin receptor CHEMBL15245 CHEMBL1909108 (2)
0 / 0
P41597 C-C chemokine receptor type 2 CC chemokine receptor CHEMBL15245 CHEMBL1909124 (2)
1 / 0
P28482 Mitogen-activated protein kinase 1 Erk CHEMBL15245 CHEMBL1909200 (2)
0 / 0
P08575 Receptor-type tyrosine-protein phosphatase C Enzyme CHEMBL15245 CHEMBL1909207 (2)
2 / 1
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 CHEMBL15245 CHEMBL31410 CHEMBL1327758 CHEMBL1514351 CHEMBL1741322 (9) CHEMBL1909132 (2)
0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme CHEMBL1327758 CHEMBL1472740 CHEMBL1514351 CHEMBL1613910 (3)
3 / 3
O76074 cGMP-specific 3',5'-cyclic phosphodiesterase PDE_5A CHEMBL15245 CHEMBL1909186 (2)
0 / 0
P03372 Estrogen receptor NR3A1 CHEMBL15245 CHEMBL1909145 (2)
1 / 1
P08588 Beta-1 adrenergic receptor Adrenergic receptor CHEMBL15245 CHEMBL1909091 (2)
1 / 0
P22303 Acetylcholinesterase Hydrolase CHEMBL15245 CHEMBL1909212 (2)
1 / 0
P28223 5-hydroxytryptamine receptor 2A Serotonin receptor CHEMBL15245 CHEMBL1909211 (2)
0 / 0
P28335 5-hydroxytryptamine receptor 2C Serotonin receptor CHEMBL15245 CHEMBL850007 (1) CHEMBL1909105 (2)
0 / 0
P35372 Mu-type opioid receptor Opioid receptor CHEMBL15245 CHEMBL1909182 (2)
0 / 0
P08173 Muscarinic acetylcholine receptor M4 Acetylcholine receptor CHEMBL15245 CHEMBL1909173 (2)
0 / 0
P25103 Substance-P receptor Neurokinin receptor CHEMBL15245 CHEMBL1909113 (2)
0 / 0
P25105 Platelet-activating factor receptor PAF receptor CHEMBL15245 CHEMBL1909187 (2)
0 / 0
P33032 Melanocortin receptor 5 Melanocortin receptor CHEMBL15245 CHEMBL1909168 (2)
0 / 0
P19838 Nuclear factor NF-kappa-B p105 subunit Transcription Factor CHEMBL31410 CHEMBL1614274 (1) CHEMBL1613823 (1)
0 / 0
P16050 Arachidonate 15-lipoxygenase Enzyme CHEMBL1472740 CHEMBL1514351 CHEMBL1614240 (2)
0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 CHEMBL15245 CHEMBL31410 CHEMBL1327758 CHEMBL1514351 CHEMBL1613777 (2) CHEMBL1741323 (9)
CHEMBL1909134 (2)
1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 CHEMBL15245 CHEMBL31410 CHEMBL1327758 CHEMBL1472740 CHEMBL1473950 CHEMBL1514351 CHEMBL1614108 (4) CHEMBL1613886 (4)
CHEMBL1741324 (9) CHEMBL1909138 (2)
0 / 1
P05181 Cytochrome P450 2E1 Cytochrome P450 2E1 CHEMBL15245 CHEMBL1909137 (2)
0 / 0
Q9UNA4 DNA polymerase iota Enzyme CHEMBL31410 CHEMBL1531132 CHEMBL1794483 (2)
0 / 0
O75164 Lysine-specific demethylase 4A Enzyme CHEMBL31410 CHEMBL1737991 (1)
0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme CHEMBL1327758 CHEMBL1614211 (1)
0 / 0
P10636 Microtubule-associated protein tau Unclassified protein CHEMBL1472740 CHEMBL1531132 CHEMBL1614250 (1) CHEMBL1614421 (2)
4 / 3
P08908 5-hydroxytryptamine receptor 1A Serotonin receptor CHEMBL10347 CHEMBL1061237 (1)
1 / 0
P23975 Sodium-dependent noradrenaline transporter Norepinephrine CHEMBL15245 CHEMBL806826 (1) CHEMBL1909094 (2)
1 / 1
P25100 Alpha-1D adrenergic receptor Adrenergic receptor CHEMBL10347 CHEMBL15245 CHEMBL31410 CHEMBL646104 (3) CHEMBL643573 (2)
CHEMBL647014 (1) CHEMBL648807 (1)
CHEMBL647813 (1) CHEMBL772607 (1)
CHEMBL1909087 (2)
0 / 0
P30542 Adenosine receptor A1 Adenosine receptor CHEMBL15245 CHEMBL1909213 (2)
0 / 0
P35368 Alpha-1B adrenergic receptor Adrenergic receptor CHEMBL10347 CHEMBL15245 CHEMBL31410 CHEMBL647014 (1) CHEMBL648807 (1)
CHEMBL647813 (1) CHEMBL648098 (2)
CHEMBL649156 (3) CHEMBL651996 (1)
CHEMBL651997 (1) CHEMBL772607 (1)
0 / 0
P18089 Alpha-2B adrenergic receptor Adrenergic receptor CHEMBL10347 CHEMBL15245 CHEMBL31410 CHEMBL196400 CHEMBL644360 (1) CHEMBL644361 (1)
CHEMBL644362 (2) CHEMBL644363 (2)
CHEMBL644364 (2) CHEMBL644527 (4)
CHEMBL644528 (4) CHEMBL644529 (4)
CHEMBL644530 (4) CHEMBL641047 (1)
CHEMBL641385 (1) CHEMBL642214 (1)
CHEMBL645606 (1) CHEMBL645613 (1)
CHEMBL646110 (1) CHEMBL646117 (1)
CHEMBL644759 (3) CHEMBL649186 (1)
CHEMBL649187 (1) CHEMBL649188 (1)
CHEMBL649189 (1) CHEMBL649190 (1)
CHEMBL649191 (1) CHEMBL649192 (1)
CHEMBL649193 (1) CHEMBL649194 (1)
CHEMBL649195 (1) CHEMBL873171 (1)
CHEMBL649196 (1) CHEMBL875438 (1)
CHEMBL649197 (1) CHEMBL648085 (1)
CHEMBL648086 (1) CHEMBL647414 (1)
CHEMBL768015 (3) CHEMBL822824 (1)
CHEMBL843759 (1) CHEMBL839550 (1)
CHEMBL1909089 (2)
0 / 0
P24557 Thromboxane-A synthase Cytochrome P450 5A1 CHEMBL15245 CHEMBL1909116 (2)
1 / 1
P06239 Tyrosine-protein kinase Lck Src CHEMBL15245 CHEMBL1909206 (2)
0 / 1
P25025 C-X-C chemokine receptor type 2 CXC chemokine receptor CHEMBL15245 CHEMBL1909128 (2)
0 / 0
Q9UBT6 DNA polymerase kappa Enzyme CHEMBL1327758 CHEMBL1794536 (1)
0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme CHEMBL1327758 CHEMBL1472740 CHEMBL1531132 CHEMBL1613914 (4)
0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme CHEMBL15245 CHEMBL31410 CHEMBL1738442 (2)
0 / 0
O00255 Menin Unclassified protein CHEMBL1327758 CHEMBL1472740 CHEMBL1514351 CHEMBL1531132 CHEMBL1614257 (2) CHEMBL1614531 (5)
2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme CHEMBL1327758 CHEMBL1472740 CHEMBL1514351 CHEMBL1531132 CHEMBL1614257 (2) CHEMBL1614531 (5)
1 / 3
Q13951 Core-binding factor subunit beta Unclassified protein CHEMBL1327758 CHEMBL1475803 CHEMBL1613933 (2)
0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein CHEMBL1327758 CHEMBL1475803 CHEMBL1613933 (2)
1 / 6
Q9NY46 Sodium channel protein type 3 subunit alpha SCN alpha, NaV1.x CHEMBL10347 CHEMBL15245 CHEMBL31410 CHEMBL806152 (1) CHEMBL806153 (3)
0 / 0
Q99250 Sodium channel protein type 2 subunit alpha SCN alpha, NaV1.x CHEMBL10347 CHEMBL15245 CHEMBL31410 CHEMBL806152 (1) CHEMBL806153 (3)
2 / 2
P35498 Sodium channel protein type 1 subunit alpha SCN alpha, NaV1.x CHEMBL10347 CHEMBL15245 CHEMBL31410 CHEMBL806152 (1) CHEMBL806153 (3)
3 / 2

CTD interaction (8)

compound gene gene name gene description interaction interaction type form reference
pmid
D015016 5243 ABCB1
ABC20
CD243
CLCS
GP170
MDR1
P-GP
PGY1
ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) Yohimbine analog results in increased expression of ABCB1 mRNA increases expression
mRNA 7476894
D015016 150 ADRA2A
ADRA2
ADRA2R
ADRAR
ALPHA2AAR
ZNF32
adrenoceptor alpha 2A Yohimbine inhibits the reaction [brimonidine promotes the reaction [Phenylephrine binds to and results in increased activity of ADRA2A protein]] affects binding
/ decreases reaction
/ increases activity
/ increases reaction
protein 10742289
D015016 150 ADRA2A
ADRA2
ADRA2R
ADRAR
ALPHA2AAR
ZNF32
adrenoceptor alpha 2A Yohimbine inhibits the reaction [Norepinephrine binds to and results in increased activity of ADRA2A protein] affects binding
/ decreases reaction
/ increases activity
protein 10742289
D015016 1082 CGB
CGB3
CGB5
CGB7
CGB8
hCGB
chorionic gonadotropin, beta polypeptide Yohimbine inhibits the reaction [amitraz inhibits the reaction [CGB protein results in increased abundance of Progesterone]] decreases reaction
/ increases abundance
protein 16085667
D015016 1082 CGB
CGB3
CGB5
CGB7
CGB8
hCGB
chorionic gonadotropin, beta polypeptide Yohimbine inhibits the reaction [amitraz results in decreased susceptibility to CGB protein] decreases reaction
/ decreases response to substance
protein 16085667
D015016 1565 CYP2D6
CPD6
CYP2D
CYP2D7AP
CYP2D7BP
CYP2D7P2
CYP2D8P2
CYP2DL1
CYPIID6
P450-DB1
P450C2D
P450DB1
cytochrome P450, family 2, subfamily D, polypeptide 6 (EC:1.14.14.1) CYP2D6 gene polymorphism affects the metabolism of Yohimbine affects metabolic processing
gene 15289791
D015016 1576 CYP3A4
CP33
CP34
CYP3A
CYP3A3
CYPIIIA3
CYPIIIA4
HLP
NF-25
P450C3
P450PCN1
cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) CYP3A4 gene polymorphism affects the metabolism of Yohimbine affects metabolic processing
gene 15289791
D015016 5617 PRL
prolactin Yohimbine results in increased expression of PRL protein increases expression
protein 3153710

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (91)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#100100 Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism P20309
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#103780 Alcohol dependence P08172
P14416
P31645
#614373 Amyotrophic lateral sclerosis 16, juvenile; als16 Q99720
#602025 Body mass index quantitative trait locus 9; bmiq9 P41968
#300615 Brunner syndrome P21397
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#162800 Cyclic neutropenia P08246
#612522 Diabetes mellitus, insulin-dependent, 22; iddm22 P51681
#607208 Dravet syndrome P35498
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#613721 Epileptic encephalopathy, early infantile, 11; eiee11 Q99250
#615363 Estrogen resistance; estrr P03372
#600274 Frontotemporal dementia; ftd P10636
#613659 Gastric cancer P04626
#137215 Gastric cancer, hereditary diffuse; hdgc P04626
#608013 Gaucher disease, perinatal lethal P04062
#230800 Gaucher disease, type i P04062
#230900 Gaucher disease, type ii P04062
#231000 Gaucher disease, type iii P04062
#231005 Gaucher disease, type iiic P04062
#604403 Generalized epilepsy with febrile seizures plus, type 2; gefsp2 P35498
#231095 Ghosal hematodiaphyseal dysplasia; ghdd P24557
#137800 Glioma susceptibility 1; glm1 P04626
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#609423 Human immunodeficiency virus type 1, susceptibility to P41597
P51681
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#145000 Hyperparathyroidism 1; hrpt1 O00255
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#612244 Inflammatory bowel disease 13; ibd13 P08183
#603932 Intervertebral disc disease; idd P14780
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#613688 Long qt syndrome 2; lqt2 Q12809
#211980 Lung cancer P00533
P04626
#608516 Major depressive disorder; mdd P08172
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#174800 Mccune-albright syndrome; mas P63092
#300705 Mental retardation, x-linked 17; mrx17 Q99714
%300852 Mental retardation, x-linked 88; mrx88 P50052
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#609634 Migraine, familial hemiplegic, 3; fhm3 P35498
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#126200 Multiple sclerosis, susceptibility to; ms P08575
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#159900 Myoclonic dystonia P14416
#202700 Neutropenia, severe congenital, 1, autosomal dominant; scn1 P08246
#257200 Niemann-pick disease, type a P17405
#607616 Niemann-pick disease, type b P17405
#601665 Obesity P32245
#164230 Obsessive-compulsive disorder; ocd P31645
#604715 Orthostatic intolerance P23975
#166350 Osseous heteroplasia, progressive; poh P63092
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#167000 Ovarian cancer P04626
#168600 Parkinson disease, late-onset; pd P04062
#260540 Parkinson-dementia syndrome P10636
#613135 Parkinsonism-dystonia, infantile; pkdys Q01959
#614674 Periodic fever, menstrual cycle-dependent P08908
#172700 Pick disease of brain P10636
#102200 Pituitary adenoma, growth hormone-secreting P63092
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#607276 Resting heart rate, variation in P08588
#275210 Restrictive dermopathy, lethal P02545
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#607745 Seizures, benign familial infantile, 3; bfis3 Q99250
#608971 Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive P08575
#609620 Short qt syndrome 1; sqt1 Q12809
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828
#190300 Tremor, hereditary essential, 1; etm1 P35462
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473
#610379 West nile virus, susceptibility to P51681
#112100 Yt blood group antigen P22303

KEGG DISEASE (76)

KEGG disease name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00016 Oral cancer P00533 (related)
P00533 (marker)
H00017 Esophageal cancer P00533 (related)
P35354 (related)
H00018 Gastric cancer P00533 (related)
P04626 (related)
H00022 Bladder cancer P00533 (related)
P04626 (related)
H00028 Choriocarcinoma P00533 (related)
P03956 (related)
P04626 (related)
H00030 Cervical cancer P00533 (related)
P04626 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00026 Endometrial Cancer P03372 (marker)
P04626 (related)
Q92731 (marker)
H00066 Lewy body dementia (LBD) P04062 (related)
H00126 Gaucher disease P04062 (related)
H00426 Defects in the degradation of ganglioside P04062 (related)
H00810 Progressive myoclonic epilepsy (PME) P04062 (related)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00019 Pancreatic cancer P04626 (related)
H00027 Ovarian cancer P04626 (related)
H00031 Breast cancer P04626 (related)
P04626 (marker)
H00046 Cholangiocarcinoma P04626 (related)
P35354 (related)
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
H00079 Asthma P07550 (related)
H00100 Neutropenic disorders P08246 (related)
H00091 T-B+Severe combined immunodeficiencies (SCIDs) P08575 (related)
H00036 Osteosarcoma P08684 (marker)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H01205 Coumarin resistance P11712 (related)
H00025 Penile cancer P14780 (related)
P35354 (related)
H00479 Metaphyseal dysplasias P14780 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00137 Niemann-Pick disease (NPD) typeA and B P17405 (related)
H00424 Defects in the degradation of sphingomyelin P17405 (related)
H00548 Brunner syndrome P21397 (related)
H01031 Orthostatic intolerance (OI) P23975 (related)
H00490 Diaphyseal dysplasia with anemia (Ghosal) P24557 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00775 Familial or sporadic hemiplegic migraine P35498 (related)
H00783 Febrile seizures P35498 (related)
H00480 Non-syndromic X-linked mental retardation P50052 (related)
Q99714 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00720 Long QT syndrome Q12809 (related)
H00725 Short QT syndrome Q12809 (related)
H00606 Early infantile epileptic encephalopathy Q99250 (related)
H00806 Benign familial neonatal and infantile epilepsies Q99250 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)

Diseases related to CTD interactions

58 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D017109 D015016 Akathisia, Drug-Induced marker/mechanism
3372705
D000435 D015016 Alcoholic Intoxication marker/mechanism
7617798
D000647 D015016 Amnesia marker/mechanism
therapeutic
15265636
20064624
D001008 D015016 Anxiety Disorders marker/mechanism
1506013
2867497
3372705
6505121
7617798
7950687
8340584
8744988
D001145 D015016 Arrhythmias, Cardiac therapeutic
2350327
D001342 D015016 Autonomic Nervous System Diseases therapeutic
8821553
D001714 D015016 Bipolar Disorder marker/mechanism
6091464
D001919 D015016 Bradycardia marker/mechanism
therapeutic
978195
1527734
2157035
3039113
3505923
3720002
6117801
6121810
8623973
D001986 D015016 Bronchial Spasm marker/mechanism
7950687
D002303 D015016 Cardiac Output, Low therapeutic
7250202
D002375 D015016 Catalepsy therapeutic
9723970
12970091
15448976
19429072
D023341 D015016 Chills marker/mechanism
3153710
D019970 D015016 Cocaine-Related Disorders marker/mechanism
14872205
18824018
D006970 D015016 Disorders of Excessive Somnolence therapeutic
8318322
D003875 D015016 Drug Eruptions marker/mechanism
8470320
D056486 D015016 Drug-Induced Liver Injury therapeutic
2886651
D064420 D015016 Drug-Related Side Effects and Adverse Reactions marker/mechanism
4022276
D004409 D015016 Dyskinesia, Drug-Induced therapeutic
8106150
10495035
D007172 D015016 Erectile Dysfunction therapeutic
3352059
10337904
11896474
17874315
D005099 D015016 Exotropia marker/mechanism
3153710
D006930 D015016 Hyperalgesia marker/mechanism
therapeutic
2128375
8987795
12727271
18799818
D006940 D015016 Hyperemia marker/mechanism
therapeutic
2841874
7949234
D006943 D015016 Hyperglycemia therapeutic
17195055
D006948 D015016 Hyperkinesis therapeutic
2880435
20542064
D006966 D015016 Hyperprolactinemia marker/mechanism
1678730
D006973 D015016 Hypertension marker/mechanism
therapeutic
1355091
2879903
3153710
3720002
6138461
7950687
8340584
8720421
10337904
19640235
D018476 D015016 Hypokinesia therapeutic
19429072
D007022 D015016 Hypotension marker/mechanism
therapeutic
978195
2157035
2565755
2594901
2767128
2879903
3039113
3421530
3720846
6111465
6117801
6121810
6256140
7250202
8816361
D007024 D015016 Hypotension, Orthostatic marker/mechanism
therapeutic
503823
2708559
2920499
3799828
3953875
7224460
10369619
D007859 D015016 Learning Disorders marker/mechanism
3153710
D001523 D015016 Mental Disorders marker/mechanism
2594901
19821221
D009069 D015016 Movement Disorders therapeutic
17306893
D009127 D015016 Muscle Rigidity therapeutic
3670563
D009203 D015016 Myocardial Infarction therapeutic
2350327
D017202 D015016 Myocardial Ischemia therapeutic
2429111
3768070
D015428 D015016 Myocardial Reperfusion Injury therapeutic
2350327
D009207 D015016 Myoclonus therapeutic
37558
D009325 D015016 Nausea marker/mechanism
3021082
D019954 D015016 Neurobehavioral Manifestations therapeutic
499336
D009765 D015016 Obesity therapeutic
2877928
D009293 D015016 Opioid-Related Disorders marker/mechanism
11955464
D016584 D015016 Panic Disorder marker/mechanism
3153710
8080348
10367182
10435213
14656453
D011141 D015016 Polyuria therapeutic
3505923
D012021 D015016 Reflex, Abnormal marker/mechanism
20394767
D051437 D015016 Renal Insufficiency marker/mechanism
8470320
D012640 D015016 Seizures marker/mechanism
therapeutic
1326092
1527734
2566944
3040437
11685388
12180996
17728537
19640235
D012735 D015016 Sexual Dysfunction, Physiological marker/mechanism
3021082
D020018 D015016 Sexual Dysfunctions, Psychological therapeutic
1535072
1564046
2295589
2868483
12187545
D013313 D015016 Stress Disorders, Post-Traumatic marker/mechanism
10435213
D019966 D015016 Substance-Related Disorders marker/mechanism
3153710
D013375 D015016 Substance Withdrawal Syndrome marker/mechanism
11955464
D013610 D015016 Tachycardia marker/mechanism
2864424
3007177
6323192
8340584
19640235
D017180 D015016 Tachycardia, Ventricular marker/mechanism
therapeutic
8720421
17852790
D014202 D015016 Tremor marker/mechanism
therapeutic
3021082
3153710
3372705
3670563
D014474 D015016 Unconsciousness marker/mechanism
19640235
D014693 D015016 Ventricular Fibrillation therapeutic
2350327
8720421
D014839 D015016 Vomiting marker/mechanism
19640235
D014987 D015016 Xerostomia therapeutic
9272401