PCIDB

KCF-S cluster No. 229 (25 metabolites)

Corresponding Phytochemical cluster No. 4

Plant Species

Cumulative plant class count

class name count
asterids 31
eudicotyledons 1

Cumulative family count

class name count
Apocynaceae 27
Hominidae 6
Rubiaceae 4
Ranunculaceae 1

KEGG BRITE br08003 External link 512

Categories (1)

br08003 Category # of metabolite
Indole alkaloids 1

metabolites link (1)

br08003 Category KEGG ID KNApSAcK ID
Indole alkaloids C09256 C00001789

Metabolite list (25)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		figure
C00001789 External link 512 Yohimbine
CHEMBL10347
CHEMBL15245
CHEMBL31410
CHEMBL196400
CHEMBL465600
CHEMBL1327758
CHEMBL1472740
CHEMBL1473950
CHEMBL1475803
CHEMBL1514351
CHEMBL1526082
CHEMBL1531132
CHEMBL1625779
CHEMBL2079555
D015016
130 / 91 / 76 6 / 58
C00025706 External link 512 10-Methoxy-17-epialloyohimbine
/ 10-Methoxy-17-epi-alloyohimbine
C00025707 External link 512 10-Methoxy-alpha-yohimbine
C00025708 External link 512 10-Methoxy-beta-yohimbine
C00025714 External link 512 11-Methoxyyohimbine
C00025722 External link 512 17-Epialloyohimbine
/ 17-epi-Alloyohimbine
CHEMBL10347
CHEMBL15245
CHEMBL31410
CHEMBL196400
CHEMBL465600
CHEMBL1327758
CHEMBL1472740
CHEMBL1473950
CHEMBL1475803
CHEMBL1514351
CHEMBL1526082
CHEMBL1531132
CHEMBL1625779
CHEMBL2079555
130 / 91 / 76
C00025744 External link 512 3,4-Dehydro-beta-yohimbine
C00025767 External link 512 Alstovenine
/ Isovenenatine
/ 3-Isovenenatine
/ (+)-Isovenenatine
CHEMBL1997080
C00025772 External link 512 Yohimbine N-oxide
/ Yohimbine beta-N-oxide
/ beta-Yohimbine N-oxide
C00025871 External link 512 Aspexcine
/ Excelsinine
C00025978 External link 512 O-Acetylalloyohimbine
/ Alloyohimbine acetate
C00025980 External link 512 O-Acetylyohimbine
/ Yohimbine acetate
/ Yohimbine 17-O-acetate
C00026014 External link 512 Poweridine
C00026015 External link 512 Powerine
C00026022 External link 512 Quaternatine
C00026075 External link 512 Venenatine
/ (-)-Venenatine
CHEMBL1997080
C425296
C00026076 External link 512 Venoxidine
/ Venenatine N-oxide
/ Venenatine Nb-oxide
C00027699 External link 512 18-Hydroxyepialloyohimbine
CHEMBL517798
1 / 0 / 0
C00027745 External link 512 3-epi-alpha-yohimbine
CHEMBL10347
CHEMBL15245
CHEMBL31410
CHEMBL196400
CHEMBL465600
CHEMBL1327758
CHEMBL1472740
CHEMBL1473950
CHEMBL1475803
CHEMBL1514351
CHEMBL1526082
CHEMBL1531132
CHEMBL1625779
CHEMBL2079555
130 / 91 / 76
C00027935 External link 512 beta-Yohimbine
CHEMBL10347
CHEMBL15245
CHEMBL31410
CHEMBL196400
CHEMBL465600
CHEMBL1327758
CHEMBL1472740
CHEMBL1473950
CHEMBL1475803
CHEMBL1514351
CHEMBL1526082
CHEMBL1531132
CHEMBL1625779
CHEMBL2079555
130 / 91 / 76
C00042639 External link 512 Isorauhimbinic acid
/ (-)-Isorauhimbinic acid
CHEMBL14730
CHEMBL148824
CHEMBL382310
CHEMBL465592
CHEMBL1338039
CHEMBL1405795
CHEMBL2104507
12 / 11 / 14
C00042737 External link 512 Methyl reserpate
CHEMBL1712538
C051349
8 / 4 / 5
C00043120 External link 512 Yohimbinic acid
CHEMBL14730
CHEMBL148824
CHEMBL382310
CHEMBL465592
CHEMBL1338039
CHEMBL1405795
CHEMBL2104507
C012612
12 / 11 / 14
C00045506 External link 512 10-Hydroxyyohimbine
C081037
C00045510 External link 512 11-Hydroxyyohimbine
C081038

Human Protein / Gene in interactions

133 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P11387 DNA topoisomerase 1 Isomerase C00001789 C00025722 C00027699 C00027745 C00027935 C00042639 C00043120 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00001789 C00025722 C00027745 C00027935 C00042639 C00043120 4 / 3
O00255 Menin Unclassified protein C00001789 C00025722 C00027745 C00027935 C00042639 C00043120 2 / 5
B2RXH2 Lysine-specific demethylase 4E Enzyme C00001789 C00025722 C00027745 C00027935 C00042639 C00043120 0 / 0
Q9UBT6 DNA polymerase kappa Enzyme C00001789 C00025722 C00027745 C00027935 C00042639 C00043120 0 / 0
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00001789 C00025722 C00027745 C00027935 C00042639 C00043120 1 / 2
P18825 Alpha-2C adrenergic receptor Adrenergic receptor C00001789 C00025722 C00027745 C00027935 C00042639 C00043120 0 / 0
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00001789 C00025722 C00027745 C00027935 C00042639 C00043120 1 / 0
P29466 Caspase-1 C14 C00001789 C00025722 C00027745 C00027935 C00042639 C00043120 0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00001789 C00025722 C00027745 C00027935 C00042639 C00043120 3 / 3
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00001789 C00025722 C00027745 C00027935 C00042639 C00043120 0 / 1
P17405 Sphingomyelin phosphodiesterase Enzyme C00001789 C00025722 C00027745 C00027935 C00042737 2 / 2
P11473 Vitamin D3 receptor NR1I1 C00001789 C00025722 C00027745 C00027935 C00042737 2 / 3
O75496 Geminin Unclassified protein C00001789 C00025722 C00027745 C00027935 C00042737 0 / 0
Q9UNA4 DNA polymerase iota Enzyme C00001789 C00025722 C00027745 C00027935 C00042737 0 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00001789 C00025722 C00027745 C00027935 C00042737 0 / 0
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00001789 C00025722 C00027745 C00027935 C00042737 0 / 0
P08173 Muscarinic acetylcholine receptor M4 Acetylcholine receptor C00001789 C00025722 C00027745 C00027935 0 / 0
P02545 Prelamin-A/C Unclassified protein C00001789 C00025722 C00027745 C00027935 11 / 10
P16473 Thyrotropin receptor Glycohormone receptor C00001789 C00025722 C00027745 C00027935 3 / 2
P10828 Thyroid hormone receptor beta NR1A2 C00001789 C00025722 C00027745 C00027935 3 / 1
P00918 Carbonic anhydrase 2 Lyase C00001789 C00025722 C00027745 C00027935 1 / 2
P07550 Beta-2 adrenergic receptor Adrenergic receptor C00001789 C00025722 C00027745 C00027935 0 / 1
P21397 Amine oxidase [flavin-containing] A Oxidoreductase C00001789 C00025722 C00027745 C00027935 1 / 1
P25021 Histamine H2 receptor Histamine receptor C00001789 C00025722 C00027745 C00027935 0 / 0
P35367 Histamine H1 receptor Histamine receptor C00001789 C00025722 C00027745 C00027935 0 / 0
Q01959 Sodium-dependent dopamine transporter Dopamine C00001789 C00025722 C00027745 C00027935 1 / 0
P08912 Muscarinic acetylcholine receptor M5 Acetylcholine receptor C00001789 C00025722 C00027745 C00027935 0 / 0
P27361 Mitogen-activated protein kinase 3 Erk C00001789 C00025722 C00027745 C00027935 0 / 0
P13945 Beta-3 adrenergic receptor Adrenergic receptor C00001789 C00025722 C00027745 C00027935 0 / 0
P08183 Multidrug resistance protein 1 drug C00001789 C00025722 C00027745 C00027935 1 / 0
P25024 C-X-C chemokine receptor type 1 CXC chemokine receptor C00001789 C00025722 C00027745 C00027935 0 / 0
P06241 Tyrosine-protein kinase Fyn Src C00001789 C00025722 C00027745 C00027935 0 / 0
Q08209 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform Ser_Thr C00001789 C00025722 C00027745 C00027935 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00001789 C00025722 C00027745 C00027935 0 / 1
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily C00001789 C00025722 C00027745 C00027935 1 / 8
P17252 Protein kinase C alpha type Alpha C00001789 C00025722 C00027745 C00027935 0 / 0
P04062 Glucosylceramidase Enzyme C00001789 C00025722 C00027745 C00027935 6 / 4
P14416 D(2) dopamine receptor Dopamine receptor C00001789 C00025722 C00027745 C00027935 2 / 0
P23219 Prostaglandin G/H synthase 1 Oxidoreductase C00001789 C00025722 C00027745 C00027935 0 / 0
P37288 Vasopressin V1a receptor Vasopressin and oxytocin receptor C00001789 C00025722 C00027745 C00027935 0 / 0
P41145 Kappa-type opioid receptor Opioid receptor C00001789 C00025722 C00027745 C00027935 0 / 0
Q9Y271 Cysteinyl leukotriene receptor 1 Leukotriene receptor C00001789 C00025722 C00027745 C00027935 0 / 0
P29274 Adenosine receptor A2a Adenosine receptor C00001789 C00025722 C00027745 C00027935 0 / 0
P25929 Neuropeptide Y receptor type 1 Neuropeptide Y receptor C00001789 C00025722 C00027745 C00027935 0 / 0
P50052 Type-2 angiotensin II receptor Angiotensin receptor C00001789 C00025722 C00027745 C00027935 1 / 1
P17948 Vascular endothelial growth factor receptor 1 Vegfr C00001789 C00025722 C00027745 C00027935 0 / 0
P41968 Melanocortin receptor 3 Melanocortin receptor C00001789 C00025722 C00027745 C00027935 1 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00001789 C00025722 C00027745 C00027935 0 / 0
P49146 Neuropeptide Y receptor type 2 Neuropeptide Y receptor C00001789 C00025722 C00027745 C00027935 0 / 0
P11509 Cytochrome P450 2A6 Cytochrome P450 2A6 C00001789 C00025722 C00027745 C00027935 0 / 0
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor C00001789 C00025722 C00027745 C00027935 0 / 0
P39748 Flap endonuclease 1 Enzyme C00001789 C00025722 C00027745 C00027935 0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme C00001789 C00025722 C00027745 C00027935 0 / 0
Q16539 Mitogen-activated protein kinase 14 p38 C00001789 C00025722 C00027745 C00027935 0 / 0
P04035 3-hydroxy-3-methylglutaryl-coenzyme A reductase Oxidoreductase C00001789 C00025722 C00027745 C00027935 0 / 0
P08913 Alpha-2A adrenergic receptor Adrenergic receptor C00001789 C00025722 C00027745 C00027935 0 / 0
P21917 D(4) dopamine receptor Dopamine receptor C00001789 C00025722 C00027745 C00027935 0 / 0
P30988 Calcitonin receptor Calcitonin receptor C00001789 C00025722 C00027745 C00027935 0 / 0
P35348 Alpha-1A adrenergic receptor Adrenergic receptor C00001789 C00025722 C00027745 C00027935 0 / 0
P35462 D(3) dopamine receptor Dopamine receptor C00001789 C00025722 C00027745 C00027935 1 / 0
P41143 Delta-type opioid receptor Opioid receptor C00001789 C00025722 C00027745 C00027935 0 / 0
Q92731 Estrogen receptor beta NR3A2 C00001789 C00025722 C00027745 C00027935 0 / 1
P41595 5-hydroxytryptamine receptor 2B Serotonin receptor C00001789 C00025722 C00027745 C00027935 0 / 0
P25101 Endothelin-1 receptor Endothelin receptor C00001789 C00025722 C00027745 C00027935 0 / 0
P30411 B2 bradykinin receptor Bradykinin receptor C00001789 C00025722 C00027745 C00027935 0 / 0
P32245 Melanocortin receptor 4 Melanocortin receptor C00001789 C00025722 C00027745 C00027935 1 / 0
P32238 Cholecystokinin receptor type A Cholecystokinin receptor C00001789 C00025722 C00027745 C00027935 0 / 0
P08311 Cathepsin G S1A C00001789 C00025722 C00027745 C00027935 0 / 0
Q99720 Sigma non-opioid intracellular receptor 1 Membrane receptor C00001789 C00025722 C00027745 C00027935 1 / 0
P03956 Interstitial collagenase M10A C00001789 C00025722 C00027745 C00027935 0 / 1
P32241 Vasoactive intestinal polypeptide receptor 1 Vasoactive intestinal peptide receptor C00001789 C00025722 C00027745 C00027935 0 / 0
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein C00001789 C00025722 C00027745 C00027935 7 / 3
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00001789 C00025722 C00027745 C00027935 0 / 0
P35498 Sodium channel protein type 1 subunit alpha SCN alpha, NaV1.x C00001789 C00025722 C00027745 C00027935 3 / 2
P04150 Glucocorticoid receptor NR3C1 C00001789 C00025722 C00027745 C00027935 0 / 1
P08172 Muscarinic acetylcholine receptor M2 Acetylcholine receptor C00001789 C00025722 C00027745 C00027935 2 / 0
P11229 Muscarinic acetylcholine receptor M1 Acetylcholine receptor C00001789 C00025722 C00027745 C00027935 0 / 0
P21554 Cannabinoid receptor 1 Cannabinoid receptor C00001789 C00025722 C00027745 C00027935 0 / 0
P31645 Sodium-dependent serotonin transporter Serotonin C00001789 C00025722 C00027745 C00027935 2 / 0
P04626 Receptor tyrosine-protein kinase erbB-2 TK tyrosine-protein kinase EGFR subfamily C00001789 C00025722 C00027745 C00027935 5 / 9
P20309 Muscarinic acetylcholine receptor M3 Acetylcholine receptor C00001789 C00025722 C00027745 C00027935 1 / 0
P21452 Substance-K receptor Neurokinin receptor C00001789 C00025722 C00027745 C00027935 0 / 0
P30304 M-phase inducer phosphatase 1 Ser_Thr_Tyr C00001789 C00025722 C00027745 C00027935 0 / 0
P51679 C-C chemokine receptor type 4 CC chemokine receptor C00001789 C00025722 C00027745 C00027935 0 / 0
P51681 C-C chemokine receptor type 5 CC chemokine receptor C00001789 C00025722 C00027745 C00027935 3 / 0
P50406 5-hydroxytryptamine receptor 6 Serotonin receptor C00001789 C00025722 C00027745 C00027935 0 / 0
P41597 C-C chemokine receptor type 2 CC chemokine receptor C00001789 C00025722 C00027745 C00027935 1 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00001789 C00025722 C00027745 C00027935 0 / 0
P08575 Receptor-type tyrosine-protein phosphatase C Enzyme C00001789 C00025722 C00027745 C00027935 2 / 1
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00001789 C00025722 C00027745 C00027935 0 / 0
P33765 Adenosine receptor A3 Adenosine receptor C00001789 C00025722 C00027745 C00027935 0 / 0
O76074 cGMP-specific 3',5'-cyclic phosphodiesterase PDE_5A C00001789 C00025722 C00027745 C00027935 0 / 0
P03372 Estrogen receptor NR3A1 C00001789 C00025722 C00027745 C00027935 1 / 1
P08588 Beta-1 adrenergic receptor Adrenergic receptor C00001789 C00025722 C00027745 C00027935 1 / 0
P22303 Acetylcholinesterase Hydrolase C00001789 C00025722 C00027745 C00027935 1 / 0
P28223 5-hydroxytryptamine receptor 2A Serotonin receptor C00001789 C00025722 C00027745 C00027935 0 / 0
P28335 5-hydroxytryptamine receptor 2C Serotonin receptor C00001789 C00025722 C00027745 C00027935 0 / 0
P35372 Mu-type opioid receptor Opioid receptor C00001789 C00025722 C00027745 C00027935 0 / 0
P14780 Matrix metalloproteinase-9 M10A C00001789 C00025722 C00027745 C00027935 2 / 2
P25103 Substance-P receptor Neurokinin receptor C00001789 C00025722 C00027745 C00027935 0 / 0
P25105 Platelet-activating factor receptor PAF receptor C00001789 C00025722 C00027745 C00027935 0 / 0
P33032 Melanocortin receptor 5 Melanocortin receptor C00001789 C00025722 C00027745 C00027935 0 / 0
Q01196 Runt-related transcription factor 1 Unclassified protein C00001789 C00025722 C00027745 C00027935 1 / 4
P16050 Arachidonate 15-lipoxygenase Enzyme C00001789 C00025722 C00027745 C00027935 0 / 0
Q99250 Sodium channel protein type 2 subunit alpha SCN alpha, NaV1.x C00001789 C00025722 C00027745 C00027935 2 / 2
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00001789 C00025722 C00027745 C00027935 1 / 1
P08246 Neutrophil elastase S1A C00001789 C00025722 C00027745 C00027935 2 / 1
P05181 Cytochrome P450 2E1 Cytochrome P450 2E1 C00001789 C00025722 C00027745 C00027935 0 / 0
Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH, Kv10-12.x (Ether-a-go-go) C00001789 C00025722 C00027745 C00027935 2 / 2
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00001789 C00025722 C00027745 C00027935 0 / 3
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00001789 C00025722 C00027745 C00027935 0 / 0
P21728 D(1A) dopamine receptor Dopamine receptor C00001789 C00025722 C00027745 C00027935 0 / 0
P08908 5-hydroxytryptamine receptor 1A Serotonin receptor C00001789 C00025722 C00027745 C00027935 1 / 0
P23975 Sodium-dependent noradrenaline transporter Norepinephrine C00001789 C00025722 C00027745 C00027935 1 / 1
P25100 Alpha-1D adrenergic receptor Adrenergic receptor C00001789 C00025722 C00027745 C00027935 0 / 0
P30542 Adenosine receptor A1 Adenosine receptor C00001789 C00025722 C00027745 C00027935 0 / 0
P35368 Alpha-1B adrenergic receptor Adrenergic receptor C00001789 C00025722 C00027745 C00027935 0 / 0
P18089 Alpha-2B adrenergic receptor Adrenergic receptor C00001789 C00025722 C00027745 C00027935 0 / 0
P24557 Thromboxane-A synthase Cytochrome P450 5A1 C00001789 C00025722 C00027745 C00027935 1 / 1
P06239 Tyrosine-protein kinase Lck Src C00001789 C00025722 C00027745 C00027935 0 / 1
P25025 C-X-C chemokine receptor type 2 CXC chemokine receptor C00001789 C00025722 C00027745 C00027935 0 / 0
P49798 Regulator of G-protein signaling 4 Unclassified protein C00001789 C00025722 C00027745 C00027935 2 / 0
Q99700 Ataxin-2 Unclassified protein C00001789 C00025722 C00027745 C00027935 1 / 1
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00001789 C00025722 C00027745 C00027935 0 / 0
Q9NY46 Sodium channel protein type 3 subunit alpha SCN alpha, NaV1.x C00001789 C00025722 C00027745 C00027935 0 / 0
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00001789 C00025722 C00027745 C00027935 0 / 0
P42345 Serine/threonine-protein kinase mTOR Enzyme C00001789 C00025722 C00027745 C00027935 0 / 0
Q13951 Core-binding factor subunit beta Unclassified protein C00001789 C00025722 C00027745 C00027935 0 / 1
P19838 Nuclear factor NF-kappa-B p105 subunit Transcription Factor C00001789 C00025722 C00027745 C00027935 0 / 0
P55210 Caspase-7 C14 C00042639 C00043120 0 / 0
Q8IUX4 DNA dC->dU-editing enzyme APOBEC-3F Enzyme C00042737 0 / 0
Q99816 Tumor susceptibility gene 101 protein Unclassified protein C00042737 0 / 0

6 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
5243 ABCB1, ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) C00001789
150 ADRA2A, ADRA2, ADRA2R, ADRAR, ALPHA2AAR, ZNF32 adrenoceptor alpha 2A C00001789
1082 CGB, CGB3, CGB5, CGB7, CGB8, hCGB chorionic gonadotropin, beta polypeptide C00001789
1565 CYP2D6, CPD6, CYP2D, CYP2D7AP, CYP2D7BP, CYP2D7P2, CYP2D8P2, CYP2DL1, CYPIID6, P450-DB1, P450C2D, P450DB1 cytochrome P450, family 2, subfamily D, polypeptide 6 (EC:1.14.14.1) C00001789
1576 CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1 cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) C00001789
5617 PRL prolactin C00001789

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (91)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#100100 Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism P20309
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#103780 Alcohol dependence P08172
P14416
P31645
#614373 Amyotrophic lateral sclerosis 16, juvenile; als16 Q99720
#602025 Body mass index quantitative trait locus 9; bmiq9 P41968
#300615 Brunner syndrome P21397
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#162800 Cyclic neutropenia P08246
#612522 Diabetes mellitus, insulin-dependent, 22; iddm22 P51681
#607208 Dravet syndrome P35498
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#613721 Epileptic encephalopathy, early infantile, 11; eiee11 Q99250
#615363 Estrogen resistance; estrr P03372
#600274 Frontotemporal dementia; ftd P10636
#613659 Gastric cancer P04626
#137215 Gastric cancer, hereditary diffuse; hdgc P04626
#608013 Gaucher disease, perinatal lethal P04062
#230800 Gaucher disease, type i P04062
#230900 Gaucher disease, type ii P04062
#231000 Gaucher disease, type iii P04062
#231005 Gaucher disease, type iiic P04062
#604403 Generalized epilepsy with febrile seizures plus, type 2; gefsp2 P35498
#231095 Ghosal hematodiaphyseal dysplasia; ghdd P24557
#137800 Glioma susceptibility 1; glm1 P04626
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#609423 Human immunodeficiency virus type 1, susceptibility to P41597
P51681
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#145000 Hyperparathyroidism 1; hrpt1 O00255
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#612244 Inflammatory bowel disease 13; ibd13 P08183
#603932 Intervertebral disc disease; idd P14780
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#613688 Long qt syndrome 2; lqt2 Q12809
#211980 Lung cancer P00533
P04626
#608516 Major depressive disorder; mdd P08172
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#174800 Mccune-albright syndrome; mas P63092
#300705 Mental retardation, x-linked 17; mrx17 Q99714
%300852 Mental retardation, x-linked 88; mrx88 P50052
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#609634 Migraine, familial hemiplegic, 3; fhm3 P35498
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#126200 Multiple sclerosis, susceptibility to; ms P08575
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#159900 Myoclonic dystonia P14416
#202700 Neutropenia, severe congenital, 1, autosomal dominant; scn1 P08246
#257200 Niemann-pick disease, type a P17405
#607616 Niemann-pick disease, type b P17405
#601665 Obesity P32245
#164230 Obsessive-compulsive disorder; ocd P31645
#604715 Orthostatic intolerance P23975
#166350 Osseous heteroplasia, progressive; poh P63092
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#167000 Ovarian cancer P04626
#168600 Parkinson disease, late-onset; pd P04062
#260540 Parkinson-dementia syndrome P10636
#613135 Parkinsonism-dystonia, infantile; pkdys Q01959
#614674 Periodic fever, menstrual cycle-dependent P08908
#172700 Pick disease of brain P10636
#102200 Pituitary adenoma, growth hormone-secreting P63092
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#607276 Resting heart rate, variation in P08588
#275210 Restrictive dermopathy, lethal P02545
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#607745 Seizures, benign familial infantile, 3; bfis3 Q99250
#608971 Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive P08575
#609620 Short qt syndrome 1; sqt1 Q12809
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828
#190300 Tremor, hereditary essential, 1; etm1 P35462
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473
#610379 West nile virus, susceptibility to P51681
#112100 Yt blood group antigen P22303

KEGG DISEASE (76)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00016 Oral cancer P00533 (related)
P00533 (marker)
H00017 Esophageal cancer P00533 (related)
P35354 (related)
H00018 Gastric cancer P00533 (related)
P04626 (related)
H00022 Bladder cancer P00533 (related)
P04626 (related)
H00028 Choriocarcinoma P00533 (related)
P03956 (related)
P04626 (related)
H00030 Cervical cancer P00533 (related)
P04626 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00026 Endometrial Cancer P03372 (marker)
P04626 (related)
Q92731 (marker)
H00066 Lewy body dementia (LBD) P04062 (related)
H00126 Gaucher disease P04062 (related)
H00426 Defects in the degradation of ganglioside P04062 (related)
H00810 Progressive myoclonic epilepsy (PME) P04062 (related)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00019 Pancreatic cancer P04626 (related)
H00027 Ovarian cancer P04626 (related)
H00031 Breast cancer P04626 (related)
P04626 (marker)
H00046 Cholangiocarcinoma P04626 (related)
P35354 (related)
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
H00079 Asthma P07550 (related)
H00100 Neutropenic disorders P08246 (related)
H00091 T-B+Severe combined immunodeficiencies (SCIDs) P08575 (related)
H00036 Osteosarcoma P08684 (marker)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H01205 Coumarin resistance P11712 (related)
H00025 Penile cancer P14780 (related)
P35354 (related)
H00479 Metaphyseal dysplasias P14780 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00137 Niemann-Pick disease (NPD) typeA and B P17405 (related)
H00424 Defects in the degradation of sphingomyelin P17405 (related)
H00548 Brunner syndrome P21397 (related)
H01031 Orthostatic intolerance (OI) P23975 (related)
H00490 Diaphyseal dysplasia with anemia (Ghosal) P24557 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00775 Familial or sporadic hemiplegic migraine P35498 (related)
H00783 Febrile seizures P35498 (related)
H00480 Non-syndromic X-linked mental retardation P50052 (related)
Q99714 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00720 Long QT syndrome Q12809 (related)
H00725 Short QT syndrome Q12809 (related)
H00606 Early infantile epileptic encephalopathy Q99250 (related)
H00806 Benign familial neonatal and infantile epilepsies Q99250 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)

Diseases related to CTD interactions

58 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D017109 Akathisia, Drug-Induced C00001789
D000435 Alcoholic Intoxication C00001789
D000647 Amnesia C00001789
D001008 Anxiety Disorders C00001789
D001145 Arrhythmias, Cardiac C00001789
D001342 Autonomic Nervous System Diseases C00001789
D001714 Bipolar Disorder C00001789
D001919 Bradycardia C00001789
D001986 Bronchial Spasm C00001789
D002303 Cardiac Output, Low C00001789
D002375 Catalepsy C00001789
D023341 Chills C00001789
D019970 Cocaine-Related Disorders C00001789
D006970 Disorders of Excessive Somnolence C00001789
D003875 Drug Eruptions C00001789
D056486 Drug-Induced Liver Injury C00001789
D064420 Drug-Related Side Effects and Adverse Reactions C00001789
D004409 Dyskinesia, Drug-Induced C00001789
D007172 Erectile Dysfunction C00001789
D005099 Exotropia C00001789
D006930 Hyperalgesia C00001789
D006940 Hyperemia C00001789
D006943 Hyperglycemia C00001789
D006948 Hyperkinesis C00001789
D006966 Hyperprolactinemia C00001789
D006973 Hypertension C00001789
D018476 Hypokinesia C00001789
D007022 Hypotension C00001789
D007024 Hypotension, Orthostatic C00001789
D007859 Learning Disorders C00001789
D001523 Mental Disorders C00001789
D009069 Movement Disorders C00001789
D009127 Muscle Rigidity C00001789
D009203 Myocardial Infarction C00001789
D017202 Myocardial Ischemia C00001789
D015428 Myocardial Reperfusion Injury C00001789
D009207 Myoclonus C00001789
D009325 Nausea C00001789
D019954 Neurobehavioral Manifestations C00001789
D009765 Obesity C00001789
D009293 Opioid-Related Disorders C00001789
D016584 Panic Disorder C00001789
D011141 Polyuria C00001789
D012021 Reflex, Abnormal C00001789
D051437 Renal Insufficiency C00001789
D012640 Seizures C00001789
D012735 Sexual Dysfunction, Physiological C00001789
D020018 Sexual Dysfunctions, Psychological C00001789
D013313 Stress Disorders, Post-Traumatic C00001789
D019966 Substance-Related Disorders C00001789
D013375 Substance Withdrawal Syndrome C00001789
D013610 Tachycardia C00001789
D017180 Tachycardia, Ventricular C00001789
D014202 Tremor C00001789
D014474 Unconsciousness C00001789
D014693 Ventricular Fibrillation C00001789
D014839 Vomiting C00001789
D014987 Xerostomia C00001789