PCIDB

KNApSAcK Metabolite C00027745

Metabolite

KNApSAcK Entry

id C00027745
Name 3-epi-alpha-yohimbine
CAS RN 483-09-0
Standard InChI InChI=1S/C21H26N2O3/c1-26-21(25)19-15-10-17-20-14(13-4-2-3-5-16(13)22-20)8-9-23(17)11-12(15)6-7-18(19)24/h2-5,12,15,17-19,22,24H,6-11H2,1H3/t12-,15+,17-,18+,19+/m1/s1
Standard InChI (Main Layer) InChI=1S/C21H26N2O3/c1-26-21(25)19-15-10-17-20-14(13-4-2-3-5-16(13)22-20)8-9-23(17)11-12(15)6-7-18(19)24/h2-5,12,15,17-19,22,24H,6-11H2,1H3

Cluster

Phytochemical cluster No. 4
KCF-S cluster No. 229

Link

ChEMBL

By standard InChI CHEMBL465600
By standard InChI Main Layer CHEMBL10347 CHEMBL15245 CHEMBL31410 CHEMBL196400 CHEMBL465600 CHEMBL1327758 CHEMBL1472740 CHEMBL1473950 CHEMBL1475803 CHEMBL1514351 CHEMBL1526082 CHEMBL1531132 CHEMBL1625779 CHEMBL2079555

KEGG

By LinkDB

CTD

By CAS RN

Species

Summary

Plant class

class name count
asterids 1

Family

family name count
Apocynaceae 1

List (1)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Rauwolfia sprucei Muell. 4059 Apocynaceae asterids Viridiplantae

Human Protein / Gene in interaction

130 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 CHEMBL15245 CHEMBL31410 CHEMBL1327758 CHEMBL1514351 CHEMBL2079555 CHEMBL729201 (1) CHEMBL729203 (1)
CHEMBL729204 (1) CHEMBL729205 (1)
CHEMBL729206 (3) CHEMBL758056 (1)
CHEMBL828928 (1) CHEMBL827154 (1)
CHEMBL1614110 (11) CHEMBL1741321 (9)
CHEMBL1909136 (2)
1 / 0
P42345 Serine/threonine-protein kinase mTOR Enzyme CHEMBL15245 CHEMBL1613805 (1)
0 / 0
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein CHEMBL31410 CHEMBL1531132 CHEMBL1738312 (2)
0 / 0
Q99700 Ataxin-2 Unclassified protein CHEMBL15245 CHEMBL1794367 (1)
1 / 1
P49798 Regulator of G-protein signaling 4 Unclassified protein CHEMBL10347 CHEMBL15245 CHEMBL31410 CHEMBL1794499 (3)
2 / 0
P21728 D(1A) dopamine receptor Dopamine receptor CHEMBL15245 CHEMBL1738091 (1) CHEMBL1738565 (1)
CHEMBL1909139 (2)
0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase CHEMBL15245 CHEMBL1909131 (2)
0 / 3
Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH, Kv10-12.x (Ether-a-go-go) CHEMBL15245 CHEMBL1909190 (2)
2 / 2
P08246 Neutrophil elastase S1A CHEMBL15245 CHEMBL1909195 (2)
2 / 1
P33765 Adenosine receptor A3 Adenosine receptor CHEMBL15245 CHEMBL881969 (1) CHEMBL1909215 (2)
0 / 0
Q16539 Mitogen-activated protein kinase 14 p38 CHEMBL15245 CHEMBL1909201 (2)
0 / 0
P49146 Neuropeptide Y receptor type 2 Neuropeptide Y receptor CHEMBL15245 CHEMBL1909176 (2)
0 / 0
P04062 Glucosylceramidase Enzyme CHEMBL1472740 CHEMBL1613818 (1)
6 / 4
P29466 Caspase-1 C14 CHEMBL15245 CHEMBL1909193 (2)
0 / 0
P17252 Protein kinase C alpha type Alpha CHEMBL15245 CHEMBL1909198 (2)
0 / 0
P27361 Mitogen-activated protein kinase 3 Erk CHEMBL15245 CHEMBL1909199 (2)
0 / 0
P14780 Matrix metalloproteinase-9 M10A CHEMBL15245 CHEMBL1909197 (2)
2 / 2
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme CHEMBL15245 CHEMBL31410 CHEMBL1531132 CHEMBL1794585 (3)
0 / 0
P02545 Prelamin-A/C Unclassified protein CHEMBL31410 CHEMBL1327758 CHEMBL1614544 (4)
11 / 10
P16473 Thyrotropin receptor Glycohormone receptor CHEMBL31410 CHEMBL1327758 CHEMBL1614281 (1) CHEMBL1614361 (3)
3 / 2
P10828 Thyroid hormone receptor beta NR1A2 CHEMBL1472740 CHEMBL1613776 (1)
3 / 1
P00918 Carbonic anhydrase 2 Lyase CHEMBL15245 CHEMBL1909123 (2)
1 / 2
P07550 Beta-2 adrenergic receptor Adrenergic receptor CHEMBL15245 CHEMBL1909092 (2)
0 / 1
P21397 Amine oxidase [flavin-containing] A Oxidoreductase CHEMBL15245 CHEMBL1909169 (2)
1 / 1
P25021 Histamine H2 receptor Histamine receptor CHEMBL15245 CHEMBL1909157 (2)
0 / 0
P35367 Histamine H1 receptor Histamine receptor CHEMBL15245 CHEMBL1909156 (2)
0 / 0
Q01959 Sodium-dependent dopamine transporter Dopamine CHEMBL15245 CHEMBL1909143 (2)
1 / 0
P08912 Muscarinic acetylcholine receptor M5 Acetylcholine receptor CHEMBL15245 CHEMBL1909174 (2)
0 / 0
P18825 Alpha-2C adrenergic receptor Adrenergic receptor CHEMBL10347 CHEMBL15245 CHEMBL31410 CHEMBL196400 CHEMBL644360 (1) CHEMBL644361 (1)
CHEMBL644362 (2) CHEMBL644363 (2)
CHEMBL644364 (2) CHEMBL644527 (4)
CHEMBL644528 (4) CHEMBL644529 (4)
CHEMBL644530 (4) CHEMBL641047 (1)
CHEMBL641385 (1) CHEMBL642214 (1)
CHEMBL645606 (1) CHEMBL645613 (1)
CHEMBL646110 (1) CHEMBL649186 (1)
CHEMBL649187 (1) CHEMBL649188 (1)
CHEMBL649189 (1) CHEMBL649190 (1)
CHEMBL649191 (1) CHEMBL649192 (1)
CHEMBL649193 (1) CHEMBL649194 (1)
CHEMBL649195 (1) CHEMBL873171 (1)
CHEMBL649196 (1) CHEMBL875438 (1)
CHEMBL649197 (1) CHEMBL648623 (3)
CHEMBL648085 (1) CHEMBL648086 (1)
CHEMBL647414 (1) CHEMBL768015 (3)
CHEMBL822824 (1) CHEMBL843759 (1)
CHEMBL829301 (1) CHEMBL1909090 (2)
0 / 0
P13945 Beta-3 adrenergic receptor Adrenergic receptor CHEMBL15245 CHEMBL1909093 (2)
0 / 0
P08183 Multidrug resistance protein 1 drug CHEMBL15245 CHEMBL1908285 (1) CHEMBL1908286 (1)
CHEMBL1908289 (1) CHEMBL1908291 (1)
CHEMBL1908292 (1)
1 / 0
P25024 C-X-C chemokine receptor type 1 CXC chemokine receptor CHEMBL15245 CHEMBL1909127 (2)
0 / 0
P06241 Tyrosine-protein kinase Fyn Src CHEMBL15245 CHEMBL1909204 (2)
0 / 0
Q08209 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform Ser_Thr CHEMBL15245 CHEMBL1909202 (2)
0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 CHEMBL15245 CHEMBL31410 CHEMBL1327758 CHEMBL1514351 CHEMBL1614027 (2) CHEMBL1741325 (9)
CHEMBL1909135 (2)
0 / 1
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily CHEMBL15245 CHEMBL1909203 (2)
1 / 11
P11387 DNA topoisomerase 1 Isomerase CHEMBL15245 CHEMBL465600 CHEMBL1003401 (3)
0 / 0
P11473 Vitamin D3 receptor NR1I1 CHEMBL1472740 CHEMBL1794311 (1)
2 / 3
P14416 D(2) dopamine receptor Dopamine receptor CHEMBL15245 CHEMBL1909140 (2)
2 / 0
P23219 Prostaglandin G/H synthase 1 Oxidoreductase CHEMBL15245 CHEMBL1909130 (2)
0 / 0
P37288 Vasopressin V1a receptor Vasopressin and oxytocin receptor CHEMBL15245 CHEMBL1909120 (2)
0 / 0
P41145 Kappa-type opioid receptor Opioid receptor CHEMBL15245 CHEMBL1909181 (2)
0 / 0
Q9Y271 Cysteinyl leukotriene receptor 1 Leukotriene receptor CHEMBL15245 CHEMBL1909164 (2)
0 / 0
P29274 Adenosine receptor A2a Adenosine receptor CHEMBL15245 CHEMBL1909214 (2)
0 / 0
P25929 Neuropeptide Y receptor type 1 Neuropeptide Y receptor CHEMBL15245 CHEMBL1909175 (2)
0 / 0
P50052 Type-2 angiotensin II receptor Angiotensin receptor CHEMBL15245 CHEMBL1909096 (2)
1 / 1
P17948 Vascular endothelial growth factor receptor 1 Vegfr CHEMBL15245 CHEMBL1909118 (2)
0 / 0
P41968 Melanocortin receptor 3 Melanocortin receptor CHEMBL15245 CHEMBL1909166 (2)
1 / 0
P00352 Retinal dehydrogenase 1 Enzyme CHEMBL31410 CHEMBL1472740 CHEMBL1614458 (2)
0 / 0
P17405 Sphingomyelin phosphodiesterase Enzyme CHEMBL31410 CHEMBL1531132 CHEMBL1794495 (2)
2 / 2
P11509 Cytochrome P450 2A6 Cytochrome P450 2A6 CHEMBL15245 CHEMBL1909133 (2)
0 / 0
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor CHEMBL31410 CHEMBL1614456 (1) CHEMBL1613803 (1)
0 / 0
P39748 Flap endonuclease 1 Enzyme CHEMBL10347 CHEMBL31410 CHEMBL1794486 (2)
0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme CHEMBL15245 CHEMBL1738606 (1)
0 / 0
O75496 Geminin Unclassified protein CHEMBL31410 CHEMBL2114780 (1)
0 / 0
P04035 3-hydroxy-3-methylglutaryl-coenzyme A reductase Oxidoreductase CHEMBL15245 CHEMBL1909158 (2)
0 / 0
P08913 Alpha-2A adrenergic receptor Adrenergic receptor CHEMBL10347 CHEMBL15245 CHEMBL31410 CHEMBL196400 CHEMBL644360 (1) CHEMBL644361 (1)
CHEMBL644362 (2) CHEMBL644363 (2)
CHEMBL644364 (2) CHEMBL644527 (4)
CHEMBL644528 (4) CHEMBL644529 (4)
CHEMBL644530 (4) CHEMBL647963 (1)
CHEMBL647721 (3) CHEMBL647725 (1)
CHEMBL641047 (1) CHEMBL641385 (1)
CHEMBL642214 (1) CHEMBL645606 (1)
CHEMBL645613 (1) CHEMBL646110 (1)
CHEMBL649186 (1) CHEMBL649187 (1)
CHEMBL649188 (1) CHEMBL649189 (1)
CHEMBL649190 (1) CHEMBL649191 (1)
CHEMBL649192 (1) CHEMBL649193 (1)
CHEMBL649194 (1) CHEMBL649195 (1)
CHEMBL873171 (1) CHEMBL649196 (1)
CHEMBL875438 (1) CHEMBL649197 (1)
CHEMBL648085 (1) CHEMBL648086 (1)
CHEMBL647414 (1) CHEMBL768015 (3)
CHEMBL822824 (1) CHEMBL843759 (1)
CHEMBL839549 (1) CHEMBL972062 (1)
CHEMBL1226896 (2) CHEMBL1227024 (1)
CHEMBL1228582 (1) CHEMBL1228583 (1)
CHEMBL1228584 (2) CHEMBL1909088 (2)
0 / 0
P21917 D(4) dopamine receptor Dopamine receptor CHEMBL15245 CHEMBL1909142 (2)
0 / 0
P30988 Calcitonin receptor Calcitonin receptor CHEMBL15245 CHEMBL1909101 (2)
0 / 0
P35348 Alpha-1A adrenergic receptor Adrenergic receptor CHEMBL10347 CHEMBL15245 CHEMBL31410 CHEMBL647014 (1) CHEMBL648807 (1)
CHEMBL647810 (2) CHEMBL647813 (1)
CHEMBL647045 (3) CHEMBL772607 (1)
CHEMBL815329 (1) CHEMBL840159 (1)
0 / 0
P35462 D(3) dopamine receptor Dopamine receptor CHEMBL15245 CHEMBL1909141 (2)
1 / 0
P41143 Delta-type opioid receptor Opioid receptor CHEMBL15245 CHEMBL1909180 (2)
0 / 0
Q92731 Estrogen receptor beta NR3A2 CHEMBL15245 CHEMBL1909146 (2)
0 / 1
P41595 5-hydroxytryptamine receptor 2B Serotonin receptor CHEMBL15245 CHEMBL850007 (1) CHEMBL1909104 (2)
0 / 0
P25101 Endothelin-1 receptor Endothelin receptor CHEMBL15245 CHEMBL1909144 (2)
0 / 0
P30411 B2 bradykinin receptor Bradykinin receptor CHEMBL15245 CHEMBL1909100 (2)
0 / 0
P32245 Melanocortin receptor 4 Melanocortin receptor CHEMBL15245 CHEMBL1909167 (2)
1 / 0
P32238 Cholecystokinin receptor type A Cholecystokinin receptor CHEMBL15245 CHEMBL1909129 (2)
0 / 0
P08311 Cathepsin G S1A CHEMBL15245 CHEMBL1909194 (2)
0 / 0
Q99720 Sigma non-opioid intracellular receptor 1 Membrane receptor CHEMBL15245 CHEMBL1909110 (2)
1 / 0
P03956 Interstitial collagenase M10A CHEMBL15245 CHEMBL1909196 (2)
0 / 1
P32241 Vasoactive intestinal polypeptide receptor 1 Vasoactive intestinal peptide receptor CHEMBL15245 CHEMBL1909119 (2)
0 / 0
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein CHEMBL1531132 CHEMBL2114810 (1)
7 / 3
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme CHEMBL1472740 CHEMBL1794467 (1)
0 / 0
P04150 Glucocorticoid receptor NR3C1 CHEMBL15245 CHEMBL1909150 (2)
0 / 1
P08172 Muscarinic acetylcholine receptor M2 Acetylcholine receptor CHEMBL15245 CHEMBL1909171 (2)
2 / 0
P11229 Muscarinic acetylcholine receptor M1 Acetylcholine receptor CHEMBL15245 CHEMBL1909170 (2)
0 / 0
P21554 Cannabinoid receptor 1 Cannabinoid receptor CHEMBL15245 CHEMBL1909122 (2)
0 / 0
P31645 Sodium-dependent serotonin transporter Serotonin CHEMBL15245 CHEMBL1909109 (2)
2 / 0
P04626 Receptor tyrosine-protein kinase erbB-2 TK tyrosine-protein kinase EGFR subfamily CHEMBL15245 CHEMBL1909205 (2)
5 / 10
P20309 Muscarinic acetylcholine receptor M3 Acetylcholine receptor CHEMBL15245 CHEMBL1909172 (2)
1 / 0
P21452 Substance-K receptor Neurokinin receptor CHEMBL15245 CHEMBL1909114 (2)
0 / 0
P30304 M-phase inducer phosphatase 1 Ser_Thr_Tyr CHEMBL15245 CHEMBL2157130 (1)
0 / 0
P51679 C-C chemokine receptor type 4 CC chemokine receptor CHEMBL15245 CHEMBL1909125 (2)
0 / 0
P51681 C-C chemokine receptor type 5 CC chemokine receptor CHEMBL15245 CHEMBL1909126 (2)
3 / 0
P50406 5-hydroxytryptamine receptor 6 Serotonin receptor CHEMBL15245 CHEMBL1909108 (2)
0 / 0
P41597 C-C chemokine receptor type 2 CC chemokine receptor CHEMBL15245 CHEMBL1909124 (2)
1 / 0
P28482 Mitogen-activated protein kinase 1 Erk CHEMBL15245 CHEMBL1909200 (2)
0 / 0
P08575 Receptor-type tyrosine-protein phosphatase C Enzyme CHEMBL15245 CHEMBL1909207 (2)
2 / 1
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 CHEMBL15245 CHEMBL31410 CHEMBL1327758 CHEMBL1514351 CHEMBL1741322 (9) CHEMBL1909132 (2)
0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme CHEMBL1327758 CHEMBL1472740 CHEMBL1514351 CHEMBL1613910 (3)
3 / 3
O76074 cGMP-specific 3',5'-cyclic phosphodiesterase PDE_5A CHEMBL15245 CHEMBL1909186 (2)
0 / 0
P03372 Estrogen receptor NR3A1 CHEMBL15245 CHEMBL1909145 (2)
1 / 1
P08588 Beta-1 adrenergic receptor Adrenergic receptor CHEMBL15245 CHEMBL1909091 (2)
1 / 0
P22303 Acetylcholinesterase Hydrolase CHEMBL15245 CHEMBL1909212 (2)
1 / 0
P28223 5-hydroxytryptamine receptor 2A Serotonin receptor CHEMBL15245 CHEMBL1909211 (2)
0 / 0
P28335 5-hydroxytryptamine receptor 2C Serotonin receptor CHEMBL15245 CHEMBL850007 (1) CHEMBL1909105 (2)
0 / 0
P35372 Mu-type opioid receptor Opioid receptor CHEMBL15245 CHEMBL1909182 (2)
0 / 0
P08173 Muscarinic acetylcholine receptor M4 Acetylcholine receptor CHEMBL15245 CHEMBL1909173 (2)
0 / 0
P25103 Substance-P receptor Neurokinin receptor CHEMBL15245 CHEMBL1909113 (2)
0 / 0
P25105 Platelet-activating factor receptor PAF receptor CHEMBL15245 CHEMBL1909187 (2)
0 / 0
P33032 Melanocortin receptor 5 Melanocortin receptor CHEMBL15245 CHEMBL1909168 (2)
0 / 0
P19838 Nuclear factor NF-kappa-B p105 subunit Transcription Factor CHEMBL31410 CHEMBL1614274 (1) CHEMBL1613823 (1)
0 / 0
P16050 Arachidonate 15-lipoxygenase Enzyme CHEMBL1472740 CHEMBL1514351 CHEMBL1614240 (2)
0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 CHEMBL15245 CHEMBL31410 CHEMBL1327758 CHEMBL1514351 CHEMBL1613777 (2) CHEMBL1741323 (9)
CHEMBL1909134 (2)
1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 CHEMBL15245 CHEMBL31410 CHEMBL1327758 CHEMBL1472740 CHEMBL1473950 CHEMBL1514351 CHEMBL1614108 (4) CHEMBL1613886 (4)
CHEMBL1741324 (9) CHEMBL1909138 (2)
0 / 1
P05181 Cytochrome P450 2E1 Cytochrome P450 2E1 CHEMBL15245 CHEMBL1909137 (2)
0 / 0
Q9UNA4 DNA polymerase iota Enzyme CHEMBL31410 CHEMBL1531132 CHEMBL1794483 (2)
0 / 0
O75164 Lysine-specific demethylase 4A Enzyme CHEMBL31410 CHEMBL1737991 (1)
0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme CHEMBL1327758 CHEMBL1614211 (1)
0 / 0
P10636 Microtubule-associated protein tau Unclassified protein CHEMBL1472740 CHEMBL1531132 CHEMBL1614250 (1) CHEMBL1614421 (2)
4 / 3
P08908 5-hydroxytryptamine receptor 1A Serotonin receptor CHEMBL10347 CHEMBL1061237 (1)
1 / 0
P23975 Sodium-dependent noradrenaline transporter Norepinephrine CHEMBL15245 CHEMBL806826 (1) CHEMBL1909094 (2)
1 / 1
P25100 Alpha-1D adrenergic receptor Adrenergic receptor CHEMBL10347 CHEMBL15245 CHEMBL31410 CHEMBL646104 (3) CHEMBL643573 (2)
CHEMBL647014 (1) CHEMBL648807 (1)
CHEMBL647813 (1) CHEMBL772607 (1)
CHEMBL1909087 (2)
0 / 0
P30542 Adenosine receptor A1 Adenosine receptor CHEMBL15245 CHEMBL1909213 (2)
0 / 0
P35368 Alpha-1B adrenergic receptor Adrenergic receptor CHEMBL10347 CHEMBL15245 CHEMBL31410 CHEMBL647014 (1) CHEMBL648807 (1)
CHEMBL647813 (1) CHEMBL648098 (2)
CHEMBL649156 (3) CHEMBL651996 (1)
CHEMBL651997 (1) CHEMBL772607 (1)
0 / 0
P18089 Alpha-2B adrenergic receptor Adrenergic receptor CHEMBL10347 CHEMBL15245 CHEMBL31410 CHEMBL196400 CHEMBL644360 (1) CHEMBL644361 (1)
CHEMBL644362 (2) CHEMBL644363 (2)
CHEMBL644364 (2) CHEMBL644527 (4)
CHEMBL644528 (4) CHEMBL644529 (4)
CHEMBL644530 (4) CHEMBL641047 (1)
CHEMBL641385 (1) CHEMBL642214 (1)
CHEMBL645606 (1) CHEMBL645613 (1)
CHEMBL646110 (1) CHEMBL646117 (1)
CHEMBL644759 (3) CHEMBL649186 (1)
CHEMBL649187 (1) CHEMBL649188 (1)
CHEMBL649189 (1) CHEMBL649190 (1)
CHEMBL649191 (1) CHEMBL649192 (1)
CHEMBL649193 (1) CHEMBL649194 (1)
CHEMBL649195 (1) CHEMBL873171 (1)
CHEMBL649196 (1) CHEMBL875438 (1)
CHEMBL649197 (1) CHEMBL648085 (1)
CHEMBL648086 (1) CHEMBL647414 (1)
CHEMBL768015 (3) CHEMBL822824 (1)
CHEMBL843759 (1) CHEMBL839550 (1)
CHEMBL1909089 (2)
0 / 0
P24557 Thromboxane-A synthase Cytochrome P450 5A1 CHEMBL15245 CHEMBL1909116 (2)
1 / 1
P06239 Tyrosine-protein kinase Lck Src CHEMBL15245 CHEMBL1909206 (2)
0 / 1
P25025 C-X-C chemokine receptor type 2 CXC chemokine receptor CHEMBL15245 CHEMBL1909128 (2)
0 / 0
Q9UBT6 DNA polymerase kappa Enzyme CHEMBL1327758 CHEMBL1794536 (1)
0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme CHEMBL1327758 CHEMBL1472740 CHEMBL1531132 CHEMBL1613914 (4)
0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme CHEMBL15245 CHEMBL31410 CHEMBL1738442 (2)
0 / 0
O00255 Menin Unclassified protein CHEMBL1327758 CHEMBL1472740 CHEMBL1514351 CHEMBL1531132 CHEMBL1614257 (2) CHEMBL1614531 (5)
2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme CHEMBL1327758 CHEMBL1472740 CHEMBL1514351 CHEMBL1531132 CHEMBL1614257 (2) CHEMBL1614531 (5)
1 / 3
Q13951 Core-binding factor subunit beta Unclassified protein CHEMBL1327758 CHEMBL1475803 CHEMBL1613933 (2)
0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein CHEMBL1327758 CHEMBL1475803 CHEMBL1613933 (2)
1 / 6
Q9NY46 Sodium channel protein type 3 subunit alpha SCN alpha, NaV1.x CHEMBL10347 CHEMBL15245 CHEMBL31410 CHEMBL806152 (1) CHEMBL806153 (3)
0 / 0
Q99250 Sodium channel protein type 2 subunit alpha SCN alpha, NaV1.x CHEMBL10347 CHEMBL15245 CHEMBL31410 CHEMBL806152 (1) CHEMBL806153 (3)
2 / 2
P35498 Sodium channel protein type 1 subunit alpha SCN alpha, NaV1.x CHEMBL10347 CHEMBL15245 CHEMBL31410 CHEMBL806152 (1) CHEMBL806153 (3)
3 / 2

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (91)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#100100 Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism P20309
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#103780 Alcohol dependence P08172
P14416
P31645
#614373 Amyotrophic lateral sclerosis 16, juvenile; als16 Q99720
#602025 Body mass index quantitative trait locus 9; bmiq9 P41968
#300615 Brunner syndrome P21397
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#162800 Cyclic neutropenia P08246
#612522 Diabetes mellitus, insulin-dependent, 22; iddm22 P51681
#607208 Dravet syndrome P35498
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#613721 Epileptic encephalopathy, early infantile, 11; eiee11 Q99250
#615363 Estrogen resistance; estrr P03372
#600274 Frontotemporal dementia; ftd P10636
#613659 Gastric cancer P04626
#137215 Gastric cancer, hereditary diffuse; hdgc P04626
#608013 Gaucher disease, perinatal lethal P04062
#230800 Gaucher disease, type i P04062
#230900 Gaucher disease, type ii P04062
#231000 Gaucher disease, type iii P04062
#231005 Gaucher disease, type iiic P04062
#604403 Generalized epilepsy with febrile seizures plus, type 2; gefsp2 P35498
#231095 Ghosal hematodiaphyseal dysplasia; ghdd P24557
#137800 Glioma susceptibility 1; glm1 P04626
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#609423 Human immunodeficiency virus type 1, susceptibility to P41597
P51681
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#145000 Hyperparathyroidism 1; hrpt1 O00255
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#612244 Inflammatory bowel disease 13; ibd13 P08183
#603932 Intervertebral disc disease; idd P14780
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#613688 Long qt syndrome 2; lqt2 Q12809
#211980 Lung cancer P00533
P04626
#608516 Major depressive disorder; mdd P08172
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#174800 Mccune-albright syndrome; mas P63092
#300705 Mental retardation, x-linked 17; mrx17 Q99714
%300852 Mental retardation, x-linked 88; mrx88 P50052
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#609634 Migraine, familial hemiplegic, 3; fhm3 P35498
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#126200 Multiple sclerosis, susceptibility to; ms P08575
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#159900 Myoclonic dystonia P14416
#202700 Neutropenia, severe congenital, 1, autosomal dominant; scn1 P08246
#257200 Niemann-pick disease, type a P17405
#607616 Niemann-pick disease, type b P17405
#601665 Obesity P32245
#164230 Obsessive-compulsive disorder; ocd P31645
#604715 Orthostatic intolerance P23975
#166350 Osseous heteroplasia, progressive; poh P63092
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#167000 Ovarian cancer P04626
#168600 Parkinson disease, late-onset; pd P04062
#260540 Parkinson-dementia syndrome P10636
#613135 Parkinsonism-dystonia, infantile; pkdys Q01959
#614674 Periodic fever, menstrual cycle-dependent P08908
#172700 Pick disease of brain P10636
#102200 Pituitary adenoma, growth hormone-secreting P63092
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#607276 Resting heart rate, variation in P08588
#275210 Restrictive dermopathy, lethal P02545
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#607745 Seizures, benign familial infantile, 3; bfis3 Q99250
#608971 Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive P08575
#609620 Short qt syndrome 1; sqt1 Q12809
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828
#190300 Tremor, hereditary essential, 1; etm1 P35462
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473
#610379 West nile virus, susceptibility to P51681
#112100 Yt blood group antigen P22303

KEGG DISEASE (76)

KEGG disease name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00016 Oral cancer P00533 (related)
P00533 (marker)
H00017 Esophageal cancer P00533 (related)
P35354 (related)
H00018 Gastric cancer P00533 (related)
P04626 (related)
H00022 Bladder cancer P00533 (related)
P04626 (related)
H00028 Choriocarcinoma P00533 (related)
P03956 (related)
P04626 (related)
H00030 Cervical cancer P00533 (related)
P04626 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00026 Endometrial Cancer P03372 (marker)
P04626 (related)
Q92731 (marker)
H00066 Lewy body dementia (LBD) P04062 (related)
H00126 Gaucher disease P04062 (related)
H00426 Defects in the degradation of ganglioside P04062 (related)
H00810 Progressive myoclonic epilepsy (PME) P04062 (related)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00019 Pancreatic cancer P04626 (related)
H00027 Ovarian cancer P04626 (related)
H00031 Breast cancer P04626 (related)
P04626 (marker)
H00046 Cholangiocarcinoma P04626 (related)
P35354 (related)
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
H00079 Asthma P07550 (related)
H00100 Neutropenic disorders P08246 (related)
H00091 T-B+Severe combined immunodeficiencies (SCIDs) P08575 (related)
H00036 Osteosarcoma P08684 (marker)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H01205 Coumarin resistance P11712 (related)
H00025 Penile cancer P14780 (related)
P35354 (related)
H00479 Metaphyseal dysplasias P14780 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00137 Niemann-Pick disease (NPD) typeA and B P17405 (related)
H00424 Defects in the degradation of sphingomyelin P17405 (related)
H00548 Brunner syndrome P21397 (related)
H01031 Orthostatic intolerance (OI) P23975 (related)
H00490 Diaphyseal dysplasia with anemia (Ghosal) P24557 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00775 Familial or sporadic hemiplegic migraine P35498 (related)
H00783 Febrile seizures P35498 (related)
H00480 Non-syndromic X-linked mental retardation P50052 (related)
Q99714 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00720 Long QT syndrome Q12809 (related)
H00725 Short QT syndrome Q12809 (related)
H00606 Early infantile epileptic encephalopathy Q99250 (related)
H00806 Benign familial neonatal and infantile epilepsies Q99250 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)