PCIDB

KNApSAcK Metabolite C00017972

Metabolite

KNApSAcK Entry

id C00017972
Name Phosphoramidon
CAS RN 36357-77-4
Standard InChI InChI=1S/C23H34N3O10P/c1-11(2)8-16(26-37(33,34)36-23-20(29)19(28)18(27)12(3)35-23)21(30)25-17(22(31)32)9-13-10-24-15-7-5-4-6-14(13)15/h4-7,10-12,16-20,23-24,27-29H,8-9H2,1-3H3,(H,25,30)(H,31,32)(H2,26,33,34)/t12?,16-,17-,18-,19+,20?,23-/m0/s1
Standard InChI (Main Layer) InChI=1S/C23H34N3O10P/c1-11(2)8-16(26-37(33,34)36-23-20(29)19(28)18(27)12(3)35-23)21(30)25-17(22(31)32)9-13-10-24-15-7-5-4-6-14(13)15/h4-7,10-12,16-20,23-24,27-29H,8-9H2,1-3H3,(H,25,30)(H,31,32)(H2,26,33,34)

Cluster

Phytochemical cluster
KCF-S cluster No. 5720

Link

ChEMBL

By standard InChI
By standard InChI Main Layer CHEMBL418012 CHEMBL41289 CHEMBL479579 CHEMBL563250 CHEMBL1318812 CHEMBL1742968

KEGG

By LinkDB C00563

CTD

By CAS RN C008890

Species

Summary

Plant class

class name count

Family

family name count
Streptomycetaceae 1

List (1)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Streptomyces tanashiensis MD706-Y4 1883 Streptomycetaceae Bacteria

Human Protein / Gene in interaction

7 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P49798 Regulator of G-protein signaling 4 Unclassified protein CHEMBL1318812 CHEMBL1794499 (1)
2 / 0
P21728 D(1A) dopamine receptor Dopamine receptor CHEMBL1318812 CHEMBL1738091 (1)
0 / 0
P42892 Endothelin-converting enzyme 1 M13 CHEMBL479579 CHEMBL675440 (1) CHEMBL675442 (1)
CHEMBL675914 (1) CHEMBL675916 (1)
CHEMBL675918 (1) CHEMBL675919 (1)
CHEMBL676076 (1) CHEMBL679843 (1)
CHEMBL679847 (1) CHEMBL878272 (1)
CHEMBL843957 (1) CHEMBL827985 (1)
CHEMBL1060020 (1) CHEMBL1045249 (1)
1 / 0
P39748 Flap endonuclease 1 Enzyme CHEMBL1318812 CHEMBL1794486 (1)
0 / 0
P12821 Angiotensin-converting enzyme M2 CHEMBL41289 CHEMBL646945 (1)
4 / 2
P08473 Neprilysin M13 CHEMBL479579 CHEMBL754362 (1) CHEMBL754363 (1)
CHEMBL751028 (1) CHEMBL1045248 (1)
CHEMBL1833759 (1)
0 / 2
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme CHEMBL1318812 CHEMBL1738442 (1)
0 / 0

CTD interaction (9)

compound gene gene name gene description interaction interaction type form reference
pmid
C008890 207 AKT1
AKT
CWS6
PKB
PKB-ALPHA
PRKBA
RAC
RAC-ALPHA
v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) phosphoramidon inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of AKT1 protein] decreases reaction
/ increases activity
/ increases phosphorylation
protein 15177934
C008890 1956 EGFR
ERBB
ERBB1
HER1
PIG61
mENA
epidermal growth factor receptor (EC:2.7.10.1) phosphoramidon inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of EGFR protein] decreases reaction
/ increases activity
/ increases phosphorylation
protein 15177934
C008890 3792 KEL
CD238
ECE3
Kell blood group, metallo-endopeptidase (EC:3.4.24.-) KEL protein alternative form binds to and affects the metabolism of phosphoramidon affects binding
/ affects metabolic processing
protein 15769748
C008890 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) phosphoramidon inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK1 protein] decreases reaction
/ increases activity
/ increases phosphorylation
protein 15177934
C008890 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) phosphoramidon inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK3 protein] decreases reaction
/ increases activity
/ increases phosphorylation
protein 15177934
C008890 4922 NTS
NMN-125
NN
NT
NT/N
NTS1
neurotensin phosphoramidon inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of AKT1 protein] decreases reaction
/ increases activity
/ increases phosphorylation
protein 15177934
C008890 4922 NTS
NMN-125
NN
NT
NT/N
NTS1
neurotensin phosphoramidon inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of EGFR protein] decreases reaction
/ increases activity
/ increases phosphorylation
protein 15177934
C008890 4922 NTS
NMN-125
NN
NT
NT/N
NTS1
neurotensin phosphoramidon inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK1 protein] decreases reaction
/ increases activity
/ increases phosphorylation
protein 15177934
C008890 4922 NTS
NMN-125
NN
NT
NT/N
NTS1
neurotensin phosphoramidon inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK3 protein] decreases reaction
/ increases activity
/ increases phosphorylation
protein 15177934

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (7)

OMIM preferred title UniProt
#614519 Hemorrhage, intracerebral, susceptibility to; ich P12821
#613870 Hirschsprung disease, cardiac defects, and autonomic dysfunction P42892
#612624 Microvascular complications of diabetes, susceptibility to, 3; mvcd3 P12821
#267430 Renal tubular dysgenesis; rtd P12821
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#601367 Stroke, ischemic P12821

KEGG DISEASE (4)

KEGG disease name UniProt
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) P08473 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) P08473 (marker)
H00083 Allograft rejection P12821 (related)
H00575 Renal tubular dysgenesis P12821 (related)

Diseases related to CTD interactions

5 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D004487 C008890 Edema marker/mechanism
7508328
D006973 C008890 Hypertension therapeutic
3443423
D013272 C008890 Stomach Diseases therapeutic
16280098
D013276 C008890 Stomach Ulcer therapeutic
11145282
D013375 C008890 Substance Withdrawal Syndrome therapeutic
3539055