PCIDB

KNApSAcK Metabolite C00018091

Metabolite

KNApSAcK Entry

id C00018091
Name MM 14151 / BRL 14151 / Clavulanic acid / Antibiotic MM 14151
CAS RN 58001-44-8
Standard InChI InChI=1S/C8H9NO5/c10-2-1-4-7(8(12)13)9-5(11)3-6(9)14-4/h1,6-7,10H,2-3H2,(H,12,13)/b4-1-/t6-,7-/m1/s1
Standard InChI (Main Layer) InChI=1S/C8H9NO5/c10-2-1-4-7(8(12)13)9-5(11)3-6(9)14-4/h1,6-7,10H,2-3H2,(H,12,13)

Cluster

Phytochemical cluster
KCF-S cluster No. 6487

Link

ChEMBL

By standard InChI CHEMBL777
By standard InChI Main Layer CHEMBL777 CHEMBL1625527

KEGG

By LinkDB C06662

CTD

By CAS RN D019818

Species

Summary

Plant class

class name count

Family

family name count
Streptomycetaceae 1

List (1)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Streptomyces clavuligerus ATCC 27064 443255 Streptomycetaceae Bacteria

Human Protein / Gene in interaction

6 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 CHEMBL777 CHEMBL2071965 (1)
1 / 0
P08246 Neutrophil elastase S1A CHEMBL777 CHEMBL676197 (1)
2 / 1
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 CHEMBL777 CHEMBL2071963 (1)
0 / 1
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 CHEMBL777 CHEMBL2071962 (1)
0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 CHEMBL777 CHEMBL2071964 (1)
1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 CHEMBL777 CHEMBL2071966 (1) CHEMBL2071967 (1)
0 / 1

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (4)

OMIM preferred title UniProt
#162800 Cyclic neutropenia P08246
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#202700 Neutropenia, severe congenital, 1, autosomal dominant; scn1 P08246

KEGG DISEASE (4)

KEGG disease name UniProt
H00100 Neutropenic disorders P08246 (related)
H00036 Osteosarcoma P08684 (marker)
H01205 Coumarin resistance P11712 (related)
H01171 Poor drug metabolism (PM) P33261 (related)

Diseases related to CTD interactions

5 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D000799 D019818 Angioedema marker/mechanism
19080805
D002779 D019818 Cholestasis marker/mechanism
2791808
D004342 D019818 Drug Hypersensitivity marker/mechanism
19080805
D056486 D019818 Drug-Induced Liver Injury marker/mechanism
2791808
D005076 D019818 Exanthema marker/mechanism
2791808