Species

KNApSAcK Entry

Organism name Streptomyces clavuligerus ATCC 27064
Genus Streptomyces
Family Streptomycetaceae
Kingdom Bacteria

NCBI taxonomy

Entry

Linked NCBI taxonomy name Streptomyces clavuligerus ATCC 27064
Linked NCBI taxonomy ID 443255
Linked level no rank

Family

Family in NCBI taxonomy Streptomycetaceae
ID 2062

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Bacteria
ID 2

Plant class

Plant class
ID

Metabolite list (1)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00018091 External link 512 MM 14151
/ BRL 14151
/ Clavulanic acid
/ Antibiotic MM 14151
CHEMBL777
CHEMBL1625527
D019818
6 / 4 / 4 0 / 5 No. 6487

Human Protein / Gene in interactions

6 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00018091 1 / 0
P08246 Neutrophil elastase S1A C00018091 2 / 1
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00018091 0 / 1
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00018091 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00018091 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00018091 0 / 1

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (4)

OMIM preferred title UniProt
#162800 Cyclic neutropenia P08246
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#202700 Neutropenia, severe congenital, 1, autosomal dominant; scn1 P08246

KEGG DISEASE (4)

KEGG name UniProt
H00100 Neutropenic disorders P08246 (related)
H00036 Osteosarcoma P08684 (marker)
H01205 Coumarin resistance P11712 (related)
H01171 Poor drug metabolism (PM) P33261 (related)

Diseases related to CTD interactions

5 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D000799 Angioedema C00018091
D002779 Cholestasis C00018091
D004342 Drug Hypersensitivity C00018091
D056486 Drug-Induced Liver Injury C00018091
D005076 Exanthema C00018091