PCIDB

KNApSAcK Metabolite C00018096

Metabolite

KNApSAcK Entry

id C00018096
Name Medermycin / Antibiotic K 73A / Lactoquinomycin A
CAS RN 60227-09-0
Standard InChI InChI=1S/C24H27NO8/c1-9-17-19(24-15(31-9)8-16(26)33-24)22(29)12-6-5-11(21(28)18(12)23(17)30)14-7-13(25(3)4)20(27)10(2)32-14/h5-6,9-10,13-15,20,24,27-28H,7-8H2,1-4H3/t9-,10?,13-,14-,15-,20-,24+/m1/s1
Standard InChI (Main Layer) InChI=1S/C24H27NO8/c1-9-17-19(24-15(31-9)8-16(26)33-24)22(29)12-6-5-11(21(28)18(12)23(17)30)14-7-13(25(3)4)20(27)10(2)32-14/h5-6,9-10,13-15,20,24,27-28H,7-8H2,1-4H3

Cluster

Phytochemical cluster
KCF-S cluster No. 2557

Link

ChEMBL

By standard InChI
By standard InChI Main Layer CHEMBL2216825

KEGG

By LinkDB C12437

CTD

By CAS RN C013104

Species

Summary

Plant class

class name count

Family

family name count
Streptomycetaceae 1

List (1)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Streptomyces tanashiensis K73 1883 Streptomycetaceae Bacteria

Human Protein / Gene in interaction

45 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
Q02750 Dual specificity mitogen-activated protein kinase kinase 1 Ste7 CHEMBL2216825 CHEMBL1019622 (1)
1 / 1
P08069 Insulin-like growth factor 1 receptor TK tyrosine-protein kinase INSR subfamily CHEMBL2216825 CHEMBL1019617 (1)
1 / 3
Q16539 Mitogen-activated protein kinase 14 p38 CHEMBL2216825 CHEMBL1019625 (1)
0 / 0
P41240 Tyrosine-protein kinase CSK Csk CHEMBL2216825 CHEMBL1019610 (1)
0 / 0
P17252 Protein kinase C alpha type Alpha CHEMBL2216825 CHEMBL1019635 (1)
0 / 0
P27361 Mitogen-activated protein kinase 3 Erk CHEMBL2216825 CHEMBL1019626 (1)
0 / 0
P04629 High affinity nerve growth factor receptor Trk CHEMBL2216825 CHEMBL1019629 (1)
2 / 4
Q04759 Protein kinase C theta type Delta CHEMBL2216825 CHEMBL1019636 (1)
0 / 1
Q15303 Receptor tyrosine-protein kinase erbB-4 TK tyrosine-protein kinase EGFR subfamily CHEMBL2216825 CHEMBL1019612 (1)
0 / 0
O14757 Serine/threonine-protein kinase Chk1 Chk1 CHEMBL2216825 CHEMBL1019608 (1)
0 / 0
O14965 Aurora kinase A Aur CHEMBL2216825 CHEMBL1019642 (1)
0 / 0
P21709 Ephrin type-A receptor 1 Eph CHEMBL2216825 CHEMBL1019645 (1)
0 / 0
P00519 Tyrosine-protein kinase ABL1 Abl CHEMBL2216825 CHEMBL1018810 (1)
1 / 4
P24941 Cyclin-dependent kinase 2 Cdc2 CHEMBL2216825 CHEMBL1019607 (1)
0 / 0
P06241 Tyrosine-protein kinase Fyn Src CHEMBL2216825 CHEMBL1019616 (1)
0 / 0
P06493 Cyclin-dependent kinase 1 Cdc2 CHEMBL2216825 CHEMBL1018814 (1)
0 / 0
P16234 Platelet-derived growth factor receptor alpha Pdgfr CHEMBL2216825 CHEMBL1019630 (1)
2 / 1
P23443 Ribosomal protein S6 kinase beta-1 p70 CHEMBL2216825 CHEMBL1019639 (1)
0 / 0
Q06187 Tyrosine-protein kinase BTK Tec CHEMBL2216825 CHEMBL1018813 (1)
2 / 2
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily CHEMBL2216825 CHEMBL1019611 (1)
1 / 11
P31751 RAC-beta serine/threonine-protein kinase Akt CHEMBL2216825 CHEMBL1018812 (1)
2 / 2
O14920 Inhibitor of nuclear factor kappa-B kinase subunit beta Other serine/threonine protein kinase CHEMBL2216825 CHEMBL1019618 (1)
0 / 0
Q13464 Rho-associated protein kinase 1 Rock CHEMBL2216825 CHEMBL1019638 (1)
0 / 0
P17948 Vascular endothelial growth factor receptor 1 Vegfr CHEMBL2216825 CHEMBL1019614 (1)
0 / 0
P36888 Receptor-type tyrosine-protein kinase FLT3 Pdgfr CHEMBL2216825 CHEMBL1019615 (1)
1 / 1
P07947 Tyrosine-protein kinase Yes Src CHEMBL2216825 CHEMBL1019644 (1)
0 / 0
Q05397 Focal adhesion kinase 1 Fak CHEMBL2216825 CHEMBL1019637 (1)
0 / 0
P51955 Serine/threonine-protein kinase Nek2 Nek CHEMBL2216825 CHEMBL1019628 (1)
0 / 0
P06213 Insulin receptor TK tyrosine-protein kinase INSR subfamily CHEMBL2216825 CHEMBL1019619 (1)
5 / 4
P09619 Platelet-derived growth factor receptor beta Pdgfr CHEMBL2216825 CHEMBL1019631 (1)
5 / 1
P12931 Proto-oncogene tyrosine-protein kinase Src Src CHEMBL2216825 CHEMBL1019641 (1)
0 / 0
P35968 Vascular endothelial growth factor receptor 2 Vegfr CHEMBL2216825 CHEMBL1019620 (1)
1 / 0
P08581 Hepatocyte growth factor receptor TK tyrosine-protein kinase MET subfamily CHEMBL2216825 CHEMBL1019627 (1)
2 / 3
P28482 Mitogen-activated protein kinase 1 Erk CHEMBL2216825 CHEMBL1019624 (1)
0 / 0
Q9Y4K4 Mitogen-activated protein kinase kinase kinase kinase 5 STE serine/threonine protein kinase KHS subfamily CHEMBL2216825 CHEMBL1019623 (1)
0 / 0
P11362 Fibroblast growth factor receptor 1 Fgfr CHEMBL2216825 CHEMBL1019613 (1)
4 / 5
P53350 Serine/threonine-protein kinase PLK1 PLK serine/threonine protein kinase subfamily CHEMBL2216825 CHEMBL1019633 (1)
0 / 0
P07948 Tyrosine-protein kinase Lyn Src CHEMBL2216825 CHEMBL1019646 (1)
0 / 0
P31749 RAC-alpha serine/threonine-protein kinase Akt CHEMBL2216825 CHEMBL1018804 (1) CHEMBL1018811 (1)
CHEMBL2217254 (1)
4 / 1
Q15118 [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial Pdhk CHEMBL2216825 CHEMBL1019632 (1)
0 / 0
O00141 Serine/threonine-protein kinase Sgk1 AGC serine/threonine protein kinase SGK subfamily CHEMBL2216825 CHEMBL1019640 (1)
0 / 0
P07333 Macrophage colony-stimulating factor 1 receptor Pdgfr CHEMBL2216825 CHEMBL1019609 (1)
1 / 1
P06239 Tyrosine-protein kinase Lck Src CHEMBL2216825 CHEMBL1019621 (1)
0 / 1
P43405 Tyrosine-protein kinase SYK Syk CHEMBL2216825 CHEMBL1019643 (1)
0 / 0
P17612 cAMP-dependent protein kinase catalytic subunit alpha Pka CHEMBL2216825 CHEMBL1019634 (1)
0 / 0

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (33)

OMIM preferred title UniProt
#300755 Agammaglobulinemia, x-linked; xla Q06187
#615007 Basal ganglia calcification, idiopathic, 4; ibgc4 P09619
#114480 Breast cancer P31749
#615279 Cardiofaciocutaneous syndrome 3; cfc3 Q02750
#114500 Colorectal cancer; crc P31749
#615109 Cowden syndrome 6; cws6 P31749
#610549 Diabetes mellitus, insulin-resistant, with acanthosis nigricans P06213
#125853 Diabetes mellitus, noninsulin-dependent; niddm P06213
P31751
#246200 Donohue syndrome P06213
#606764 Gastrointestinal stromal tumor; gist P16234
#602089 Hemangioma, capillary infantile P35968
#114550 Hepatocellular carcinoma P08581
#607685 Hypereosinophilic syndrome, idiopathic; hes P16234
#609968 Hyperinsulinemic hypoglycemia, familial, 5; hhf5 P06213
#147950 Hypogonadotropic hypogonadism 2 with or without anosmia; hh2 P11362
#240900 Hypoinsulinemic hypoglycemia with hemihypertrophy; hihghh P31751
#256800 Insensitivity to pain, congenital, with anhidrosis; cipa P04629
#270450 Insulin-like growth factor i, resistance to P08069
#307200 Isolated growth hormone deficiency, type iii; ighd3 Q06187
#607785 Juvenile myelomonocytic leukemia; jmml P09619
#601626 Leukemia, acute myeloid; aml P09619
P36888
#608232 Leukemia, chronic myeloid; cml P00519
#221820 Leukoencephalopathy, diffuse hereditary, with spheroids; hdls P07333
#211980 Lung cancer P00533
#131440 Myeloproliferative disorder, chronic, with eosinophilia P09619
#228550 Myofibromatosis, infantile, 1; imf1 P09619
#166250 Osteoglophonic dysplasia; ogd P11362
#101600 Pfeiffer syndrome P11362
#262190 Pineal hyperplasia, insulin-resistant diabetes mellitus, and somatic abnormalities P06213
#176920 Proteus syndrome P31749
#605074 Renal cell carcinoma, papillary, 1; rccp1 P08581
#188550 Thyroid carcinoma, papillary P04629
#190440 Trigonocephaly 1; trigno1 P11362

KEGG DISEASE (36)

KEGG disease name UniProt
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) P00519 (related)
P00519 (marker)
H00004 Chronic myeloid leukemia (CML) P00519 (related)
P00519 (marker)
H00016 Oral cancer P00533 (related)
P00533 (marker)
H00017 Esophageal cancer P00533 (related)
H00018 Gastric cancer P00533 (related)
P08581 (related)
H00022 Bladder cancer P00533 (related)
H00028 Choriocarcinoma P00533 (related)
P07333 (related)
H00030 Cervical cancer P00533 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
P09619 (related)
P16234 (related)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
H00032 Thyroid cancer P04629 (related)
H00043 Neuroblastoma P04629 (related)
P04629 (marker)
H00265 Hereditary sensory and autonomic neuropathy (HSAN) P04629 (related)
H00719 Leprechaunism P06213 (related)
H00942 Rabson-Mendenhall syndrome P06213 (related)
H01228 Insulin-resistant diabetes mellitus with acanthosis nigricans (IRAN) P06213 (related)
H01267 Familial hyperinsulinemic hypoglycemia (HHF) P06213 (related)
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
H00015 Malignant pleural mesothelioma P08069 (related)
H00050 Synovial sarcoma P08069 (related)
H01274 Growth delay due to insulin-like growth factor I resistance P08069 (related)
H00021 Renal cell carcinoma P08581 (related)
H00046 Cholangiocarcinoma P08581 (related)
H00255 Hypogonadotropic hypogonadism P11362 (related)
H00443 Osteoglophonic dysplasia (OD) P11362 (related)
H00458 Craniosynostosis P11362 (related)
H00516 Isolated orofacial clefts P11362 (related)
H01207 Trigonocephaly P11362 (related)
H00539 PTEN hamartoma tumor syndrome (PHTS) P31749 (related)
H00027 Ovarian cancer P31751 (related)
H00420 Familial partial lipodystrophy (FPL) P31751 (related)
H00003 Acute myeloid leukemia (AML) P36888 (related)
H00523 Noonan syndrome and related disorders Q02750 (related)
H00408 Type I diabetes mellitus Q04759 (related)
H00085 Agammaglobulinemias Q06187 (related)
H00254 Pituitary Dwarfism (PD) Q06187 (related)