Streptomyces tanashiensis K73
Species
KNApSAcK Entry
| Organism name | Streptomyces tanashiensis K73 |
|---|---|
| Genus | Streptomyces |
| Family | Streptomycetaceae |
| Kingdom | Bacteria |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Streptomyces |
|---|---|
| Linked NCBI taxonomy ID | 1883 |
| Linked level | genus |
Family
| Family in NCBI taxonomy | Streptomycetaceae |
|---|---|
| ID | 2062 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Bacteria |
|---|---|
| ID | 2 |
Plant class
| Plant class | |
|---|---|
| ID |
Metabolite list (1)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00018096
|
Medermycin
/ Antibiotic K 73A / Lactoquinomycin A |
CHEMBL2216825
|
C013104
|
45 / 33 / 36 | No. 2557 |
|
Human Protein / Gene in interactions
45 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| Q02750 | Dual specificity mitogen-activated protein kinase kinase 1 | Ste7 | C00018096 | 1 / 1 |
| P08069 | Insulin-like growth factor 1 receptor | TK tyrosine-protein kinase INSR subfamily | C00018096 | 1 / 3 |
| Q16539 | Mitogen-activated protein kinase 14 | p38 | C00018096 | 0 / 0 |
| P41240 | Tyrosine-protein kinase CSK | Csk | C00018096 | 0 / 0 |
| P17252 | Protein kinase C alpha type | Alpha | C00018096 | 0 / 0 |
| P27361 | Mitogen-activated protein kinase 3 | Erk | C00018096 | 0 / 0 |
| P04629 | High affinity nerve growth factor receptor | Trk | C00018096 | 2 / 3 |
| Q04759 | Protein kinase C theta type | Delta | C00018096 | 0 / 1 |
| Q15303 | Receptor tyrosine-protein kinase erbB-4 | TK tyrosine-protein kinase EGFR subfamily | C00018096 | 0 / 0 |
| O14757 | Serine/threonine-protein kinase Chk1 | Chk1 | C00018096 | 0 / 0 |
| O14965 | Aurora kinase A | Aur | C00018096 | 0 / 0 |
| P21709 | Ephrin type-A receptor 1 | Eph | C00018096 | 0 / 0 |
| P00519 | Tyrosine-protein kinase ABL1 | Abl | C00018096 | 1 / 2 |
| P24941 | Cyclin-dependent kinase 2 | Cdc2 | C00018096 | 0 / 0 |
| P06241 | Tyrosine-protein kinase Fyn | Src | C00018096 | 0 / 0 |
| P06493 | Cyclin-dependent kinase 1 | Cdc2 | C00018096 | 0 / 0 |
| P16234 | Platelet-derived growth factor receptor alpha | Pdgfr | C00018096 | 2 / 1 |
| P23443 | Ribosomal protein S6 kinase beta-1 | p70 | C00018096 | 0 / 0 |
| Q06187 | Tyrosine-protein kinase BTK | Tec | C00018096 | 2 / 2 |
| P00533 | Epidermal growth factor receptor | TK tyrosine-protein kinase EGFR subfamily | C00018096 | 1 / 8 |
| P31751 | RAC-beta serine/threonine-protein kinase | Akt | C00018096 | 2 / 2 |
| O14920 | Inhibitor of nuclear factor kappa-B kinase subunit beta | Other serine/threonine protein kinase | C00018096 | 0 / 0 |
| Q13464 | Rho-associated protein kinase 1 | Rock | C00018096 | 0 / 0 |
| P17948 | Vascular endothelial growth factor receptor 1 | Vegfr | C00018096 | 0 / 0 |
| P36888 | Receptor-type tyrosine-protein kinase FLT3 | Pdgfr | C00018096 | 1 / 1 |
| P07947 | Tyrosine-protein kinase Yes | Src | C00018096 | 0 / 0 |
| Q05397 | Focal adhesion kinase 1 | Fak | C00018096 | 0 / 0 |
| P51955 | Serine/threonine-protein kinase Nek2 | Nek | C00018096 | 0 / 0 |
| P06213 | Insulin receptor | TK tyrosine-protein kinase INSR subfamily | C00018096 | 5 / 4 |
| P09619 | Platelet-derived growth factor receptor beta | Pdgfr | C00018096 | 5 / 1 |
| P12931 | Proto-oncogene tyrosine-protein kinase Src | Src | C00018096 | 0 / 0 |
| P35968 | Vascular endothelial growth factor receptor 2 | Vegfr | C00018096 | 1 / 0 |
| P08581 | Hepatocyte growth factor receptor | TK tyrosine-protein kinase MET subfamily | C00018096 | 2 / 3 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00018096 | 0 / 0 |
| Q9Y4K4 | Mitogen-activated protein kinase kinase kinase kinase 5 | STE serine/threonine protein kinase KHS subfamily | C00018096 | 0 / 0 |
| P11362 | Fibroblast growth factor receptor 1 | Fgfr | C00018096 | 4 / 5 |
| P53350 | Serine/threonine-protein kinase PLK1 | PLK serine/threonine protein kinase subfamily | C00018096 | 0 / 0 |
| P07948 | Tyrosine-protein kinase Lyn | Src | C00018096 | 0 / 0 |
| P31749 | RAC-alpha serine/threonine-protein kinase | Akt | C00018096 | 4 / 1 |
| Q15118 | [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial | Pdhk | C00018096 | 0 / 0 |
| O00141 | Serine/threonine-protein kinase Sgk1 | AGC serine/threonine protein kinase SGK subfamily | C00018096 | 0 / 0 |
| P07333 | Macrophage colony-stimulating factor 1 receptor | Pdgfr | C00018096 | 1 / 1 |
| P06239 | Tyrosine-protein kinase Lck | Src | C00018096 | 0 / 1 |
| P43405 | Tyrosine-protein kinase SYK | Syk | C00018096 | 0 / 0 |
| P17612 | cAMP-dependent protein kinase catalytic subunit alpha | Pka | C00018096 | 0 / 0 |
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (33)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300755 | Agammaglobulinemia, x-linked; xla |
Q06187
|
| #615007 | Basal ganglia calcification, idiopathic, 4; ibgc4 |
P09619
|
| #114480 | Breast cancer |
P31749
|
| #615279 | Cardiofaciocutaneous syndrome 3; cfc3 |
Q02750
|
| #114500 | Colorectal cancer; crc |
P31749
|
| #615109 | Cowden syndrome 6; cws6 |
P31749
|
| #610549 | Diabetes mellitus, insulin-resistant, with acanthosis nigricans |
P06213
|
| #125853 | Diabetes mellitus, noninsulin-dependent; niddm |
P06213
P31751 |
| #246200 | Donohue syndrome |
P06213
|
| #606764 | Gastrointestinal stromal tumor; gist |
P16234
|
| #602089 | Hemangioma, capillary infantile |
P35968
|
| #114550 | Hepatocellular carcinoma |
P08581
|
| #607685 | Hypereosinophilic syndrome, idiopathic; hes |
P16234
|
| #609968 | Hyperinsulinemic hypoglycemia, familial, 5; hhf5 |
P06213
|
| #147950 | Hypogonadotropic hypogonadism 2 with or without anosmia; hh2 |
P11362
|
| #240900 | Hypoinsulinemic hypoglycemia with hemihypertrophy; hihghh |
P31751
|
| #256800 | Insensitivity to pain, congenital, with anhidrosis; cipa |
P04629
|
| #270450 | Insulin-like growth factor i, resistance to |
P08069
|
| #307200 | Isolated growth hormone deficiency, type iii; ighd3 |
Q06187
|
| #607785 | Juvenile myelomonocytic leukemia; jmml |
P09619
|
| #601626 | Leukemia, acute myeloid; aml |
P09619
P36888 |
| #608232 | Leukemia, chronic myeloid; cml |
P00519
|
| #221820 | Leukoencephalopathy, diffuse hereditary, with spheroids; hdls |
P07333
|
| #211980 | Lung cancer |
P00533
|
| #131440 | Myeloproliferative disorder, chronic, with eosinophilia |
P09619
|
| #228550 | Myofibromatosis, infantile, 1; imf1 |
P09619
|
| #166250 | Osteoglophonic dysplasia; ogd |
P11362
|
| #101600 | Pfeiffer syndrome |
P11362
|
| #262190 | Pineal hyperplasia, insulin-resistant diabetes mellitus, and somatic abnormalities |
P06213
|
| #176920 | Proteus syndrome |
P31749
|
| #605074 | Renal cell carcinoma, papillary, 1; rccp1 |
P08581
|
| #188550 | Thyroid carcinoma, papillary |
P04629
|
| #190440 | Trigonocephaly 1; trigno1 |
P11362
|
KEGG DISEASE (36)
| KEGG | name | UniProt |
|---|---|---|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
P00519
(related)
P00519 (marker) |
| H00004 | Chronic myeloid leukemia (CML) |
P00519
(related)
P00519 (marker) |
| H00016 | Oral cancer |
P00533
(related)
P00533 (marker) |
| H00017 | Esophageal cancer |
P00533
(related)
|
| H00018 | Gastric cancer |
P00533
(related)
P08581 (related) |
| H00022 | Bladder cancer |
P00533
(related)
|
| H00028 | Choriocarcinoma |
P00533
(related)
P07333 (related) |
| H00030 | Cervical cancer |
P00533
(related)
|
| H00042 | Glioma |
P00533
(related)
P00533 (marker) P09619 (related) P16234 (related) |
| H00055 | Laryngeal cancer |
P00533
(related)
P00533 (marker) |
| H00032 | Thyroid cancer |
P04629
(related)
|
| H00043 | Neuroblastoma |
P04629
(related)
P04629 (marker) |
| H00265 | Hereditary sensory and autonomic neuropathy (HSAN) |
P04629
(related)
|
| H00719 | Leprechaunism |
P06213
(related)
|
| H00942 | Rabson-Mendenhall syndrome |
P06213
(related)
|
| H01228 | Insulin-resistant diabetes mellitus with acanthosis nigricans (IRAN) |
P06213
(related)
|
| H01267 | Familial hyperinsulinemic hypoglycemia (HHF) |
P06213
(related)
|
| H00093 | Combined immunodeficiencies (CIDs) |
P06239
(related)
|
| H00015 | Malignant pleural mesothelioma |
P08069
(related)
|
| H00050 | Synovial sarcoma |
P08069
(related)
|
| H01274 | Growth delay due to insulin-like growth factor I resistance |
P08069
(related)
|
| H00021 | Renal cell carcinoma |
P08581
(related)
|
| H00046 | Cholangiocarcinoma |
P08581
(related)
|
| H00255 | Hypogonadotropic hypogonadism |
P11362
(related)
|
| H00443 | Osteoglophonic dysplasia (OD) |
P11362
(related)
|
| H00458 | Craniosynostosis |
P11362
(related)
|
| H00516 | Isolated orofacial clefts |
P11362
(related)
|
| H01207 | Trigonocephaly |
P11362
(related)
|
| H00539 | PTEN hamartoma tumor syndrome (PHTS) |
P31749
(related)
|
| H00027 | Ovarian cancer |
P31751
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P31751
(related)
|
| H00003 | Acute myeloid leukemia (AML) |
P36888
(related)
|
| H00523 | Noonan syndrome and related disorders |
Q02750
(related)
|
| H00408 | Type I diabetes mellitus |
Q04759
(related)
|
| H00085 | Agammaglobulinemias |
Q06187
(related)
|
| H00254 | Pituitary Dwarfism (PD) |
Q06187
(related)
|