PCIDB

KNApSAcK Metabolite C00018398

Metabolite

KNApSAcK Entry

id C00018398
Name G 418 / Geneticin / Antibiotic G 418
CAS RN 49863-47-0
Standard InChI InChI=1S/C20H40N4O10/c1-6(25)14-11(27)10(26)9(23)18(32-14)33-15-7(21)4-8(22)16(12(15)28)34-19-13(29)17(24-3)20(2,30)5-31-19/h6-19,24-30H,4-5,21-23H2,1-3H3/t6?,7-,8+,9?,10+,11-,12-,13?,14?,15+,16-,17-,18+,19+,20+/m0/s1
Standard InChI (Main Layer) InChI=1S/C20H40N4O10/c1-6(25)14-11(27)10(26)9(23)18(32-14)33-15-7(21)4-8(22)16(12(15)28)34-19-13(29)17(24-3)20(2,30)5-31-19/h6-19,24-30H,4-5,21-23H2,1-3H3

Cluster

Phytochemical cluster
KCF-S cluster No. 332

Link

ChEMBL

By standard InChI
By standard InChI Main Layer CHEMBL215226 CHEMBL1620897 CHEMBL2008763

KEGG

By LinkDB C17703

CTD

By CAS RN C010680

Species

Summary

Plant class

class name count

Family

family name count
Micromonosporaceae 1

List (1)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Micromonospora sagamiensis KY 11565 1873 Micromonosporaceae Bacteria

Human Protein / Gene in interaction

CTD interaction (21)

compound gene gene name gene description interaction interaction type form reference
pmid
C010680 5243 ABCB1
ABC20
CD243
CLCS
GP170
MDR1
P-GP
PGY1
ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) ABCB1 protein results in increased transport of antibiotic G 418 increases transport
protein 20018165
C010680 5243 ABCB1
ABC20
CD243
CLCS
GP170
MDR1
P-GP
PGY1
ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) antibiotic G 418 results in decreased expression of ABCB1 mRNA decreases expression
mRNA 20018165
C010680 4363 ABCC1
ABC29
ABCC
GS-X
MRP
MRP1
ATP-binding cassette, sub-family C (CFTR/MRP), member 1 ABCC1 protein results in increased transport of antibiotic G 418 increases transport
protein 20018165
C010680 1244 ABCC2
ABC30
CMOAT
DJS
MRP2
cMRP
ATP-binding cassette, sub-family C (CFTR/MRP), member 2 ABCC2 protein results in increased transport of antibiotic G 418 increases transport
protein 20018165
C010680 8714 ABCC3
ABC31
EST90757
MLP2
MOAT-D
MRP3
cMOAT2
ATP-binding cassette, sub-family C (CFTR/MRP), member 3 ABCC3 protein results in increased transport of antibiotic G 418 increases transport
protein 20018165
C010680 472 ATM
AT1
ATA
ATC
ATD
ATDC
ATE
TEL1
TELO1
ataxia telangiectasia mutated (EC:2.7.11.1) antibiotic G 418 results in increased expression of ATM protein mutant form increases expression
protein 15498871
C010680 554 AVPR2
ADHR
DI1
DIR
DIR3
NDI
V2R
arginine vasopressin receptor 2 antibiotic G 418 results in increased expression of and results in increased activity of AVPR2 protein mutant form increases activity
/ increases expression
protein 12414899
14998935
C010680 824 CAPN2
CANP2
CANPL2
CANPml
mCANP
calpain 2, (m/II) large subunit (EC:3.4.22.53) antibiotic G 418 results in increased cleavage of CAPN2 protein increases cleavage
protein 15241557
C010680 100506742 CASP12
CASP-12
CASP12P1
caspase 12 (gene/pseudogene) antibiotic G 418 results in increased cleavage of CASP12 protein increases cleavage
protein 15241557
C010680 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) antibiotic G 418 results in increased activity of CASP3 protein increases activity
protein 15241557
C010680 842 CASP9
APAF-3
APAF3
ICE-LAP6
MCH6
PPP1R56
caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) antibiotic G 418 results in increased activity of CASP9 protein increases activity
protein 15241557
C010680 842 CASP9
APAF-3
APAF3
ICE-LAP6
MCH6
PPP1R56
caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [antibiotic G 418 results in increased activity of CASP9 protein] decreases reaction
/ increases activity
protein 15241557
C010680 1080 CFTR
ABC35
ABCC7
CF
CFTR/MRP
MRP7
TNR-CFTR
dJ760C5.1
cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) (EC:3.6.3.49) antibiotic G 418 results in increased expression of CFTR protein mutant form increases expression
protein 17541014
C010680 2155 F7
SPCA
coagulation factor VII (serum prothrombin conversion accelerator) (EC:3.4.21.21) antibiotic G 418 results in increased expression of and results in increased activity of F7 protein increases activity
/ increases expression
protein 16706976
C010680 3758 KCNJ1
KIR1.1
ROMK
ROMK1
potassium inwardly-rectifying channel, subfamily J, member 1 antibiotic G 418 results in increased expression of KCNJ1 protein mutant form increases expression
protein 12911542
C010680 4594 MUT
MCM
methylmalonyl CoA mutase (EC:5.4.99.2) antibiotic G 418 affects the expression of MUT mRNA mutant form affects expression
mRNA 19427250
C010680 4594 MUT
MCM
methylmalonyl CoA mutase (EC:5.4.99.2) [antibiotic G 418 co-treated with Gentamicins] affects the activity of MUT protein mutant form affects activity
/ affects cotreatment
protein 19427250
C010680 4594 MUT
MCM
methylmalonyl CoA mutase (EC:5.4.99.2) [antibiotic G 418 co-treated with Gentamicins] affects the expression of MUT mRNA mutant form affects cotreatment
/ affects expression
mRNA 19427250
C010680 4594 MUT
MCM
methylmalonyl CoA mutase (EC:5.4.99.2) antibiotic G 418 promotes the reaction [Gentamicins affects the expression of MUT protein mutant form] affects expression
/ increases reaction
protein 19427250
C010680 8671 SLC4A4
HNBC1
KNBC
NBC1
NBC2
NBCe1-A
SLC4A5
hhNMC
pNBC
solute carrier family 4 (sodium bicarbonate cotransporter), member 4 antibiotic G 418 results in increased expression of SLC4A4 protein mutant form increases expression
protein 18614622
C010680 6607 SMN2
BCD541
C-BCD541
GEMIN1
SMNC
TDRD16B
survival of motor neuron 2, centromeric antibiotic G 418 results in increased expression of SMN2 protein increases expression
protein 19150990