KCF-S cluster No. 332 (21 metabolites)
Plant Species
Cumulative plant class count
| class name | count |
|---|
Cumulative family count
| class name | count |
|---|---|
| Micromonosporaceae | 9 |
| Bacillaceae | 7 |
| Streptomycetaceae | 6 |
KEGG BRITE br08003
Categories (0)
| br08003 Category | # of metabolite |
|---|
metabolites link (0)
| br08003 Category | KEGG ID | KNApSAcK ID |
|---|
Metabolite list (21)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
figure |
|---|---|---|---|---|---|---|
|
C00017723
|
Bu 2659E
/ Inosamycin E |
|
||||
|
C00017960
|
Bu-1709E1
/ D-Streptamine / 6'-Deamino-6'-hydroxybutirosin A |
C006157
|
|
|||
|
C00017993
|
4'-Deoxybutirosin B
|
|
||||
|
C00018016
|
DE 020
/ XK 62-2 / KW 1062 / Sagamicin / Santemycin / Micronomicin / Gentamicin C2b / Antibiotic XK 62-2 / Antibiotic KW 1062 |
CHEMBL373081
|
C037545
|
|
||
|
C00018119
|
XX-88-1
/ XK 88-1 / Antibiotic XK 88-1 / Seldomycin factor 1 |
|
||||
|
C00018121
|
XX-88-3
/ XK 88-3 / Seldomycin factor 3 / Antibiotics XK 88-3 |
|
||||
|
C00018171
|
3',4'-Dideoxy-6'-N-methylbutirosin A
|
|
||||
|
C00018172
|
3',4'-Dideoxy-6'-N-methylbutirosin B
|
|
||||
|
C00018173
|
6'-N-Methylbutirosin A
|
|
||||
|
C00018174
|
6'-N-Methylbutirosin B
|
|
||||
|
C00018175
|
3',4'-Dideoxy-6'-C-methylbutirosin A
|
|
||||
|
C00018340
|
Combimicin A2
|
|
||||
|
C00018341
|
Combimicin B2
|
|
||||
|
C00018342
|
Combimicin B1
|
|
||||
|
C00018397
|
Gentamicin X
/ Gentamycin X / Gentamicin X2 |
C012331
|
|
|||
|
C00018398
|
G 418
/ Geneticin / Antibiotic G 418 |
CHEMBL215226
CHEMBL1620897 CHEMBL2008763 |
C010680
|
16 / 0 |
|
|
|
C00018402
|
2-Hydroxysagamicin
|
C033977
|
|
|||
|
C00018417
|
SU 1
/ Antibiotic SU 1 |
|
||||
|
C00018690
|
Kanamycin C
|
|
||||
|
C00018692
|
KDM
/ NK 1006 / Kanamycin B / Bekanamycin / Kanendomycin / Nebramycin V / Aminodeoxykanamycin / Nebramycin factor 5 / 2'-Amino-2'-deoxykanamycin |
CHEMBL176
CHEMBL1331937 CHEMBL2105594 |
C001495
|
3 / 2 / 0 | 0 / 1 |
|
|
C00018782
|
SF 733
/ Vistamycin / NSC 138925 / Hetangmycin / Ribostamycin / Dekamycin IV / Antibiotic SF 733 |
CHEMBL300914
CHEMBL221572 CHEMBL1481003 CHEMBL1617486 |
D012271
|
7 / 13 / 13 | 0 / 1 |
|
Human Protein / Gene in interactions
10 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00018782 | 1 / 0 |
| P02545 | Prelamin-A/C | Unclassified protein | C00018782 | 11 / 10 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00018782 | 0 / 1 |
| P14416 | D(2) dopamine receptor | Dopamine receptor | C00018692 | 2 / 0 |
| Q92830 | Histone acetyltransferase KAT2A | Enzyme | C00018782 | 0 / 0 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00018782 | 0 / 0 |
| P16050 | Arachidonate 15-lipoxygenase | Enzyme | C00018692 | 0 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00018782 | 1 / 1 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00018782 | 0 / 1 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00018692 | 0 / 0 |
16 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 5243 | ABCB1, ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1 | ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) |
C00018398
|
| 4363 | ABCC1, ABC29, ABCC, GS-X, MRP, MRP1 | ATP-binding cassette, sub-family C (CFTR/MRP), member 1 |
C00018398
|
| 1244 | ABCC2, ABC30, CMOAT, DJS, MRP2, cMRP | ATP-binding cassette, sub-family C (CFTR/MRP), member 2 |
C00018398
|
| 8714 | ABCC3, ABC31, EST90757, MLP2, MOAT-D, MRP3, cMOAT2 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 |
C00018398
|
| 472 | ATM, AT1, ATA, ATC, ATD, ATDC, ATE, TEL1, TELO1 | ataxia telangiectasia mutated (EC:2.7.11.1) |
C00018398
|
| 554 | AVPR2, ADHR, DI1, DIR, DIR3, NDI, V2R | arginine vasopressin receptor 2 |
C00018398
|
| 824 | CAPN2, CANP2, CANPL2, CANPml, mCANP | calpain 2, (m/II) large subunit (EC:3.4.22.53) |
C00018398
|
| 100506742 | CASP12, CASP-12, CASP12P1 | caspase 12 (gene/pseudogene) |
C00018398
|
| 836 | CASP3, CPP32, CPP32B, SCA-1 | caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) |
C00018398
|
| 842 | CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56 | caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) |
C00018398
|
| 1080 | CFTR, ABC35, ABCC7, CF, CFTR/MRP, MRP7, TNR-CFTR, dJ760C5.1 | cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) (EC:3.6.3.49) |
C00018398
|
| 2155 | F7, SPCA | coagulation factor VII (serum prothrombin conversion accelerator) (EC:3.4.21.21) |
C00018398
|
| 3758 | KCNJ1, KIR1.1, ROMK, ROMK1 | potassium inwardly-rectifying channel, subfamily J, member 1 |
C00018398
|
| 4594 | MUT, MCM | methylmalonyl CoA mutase (EC:5.4.99.2) |
C00018398
|
| 8671 | SLC4A4, HNBC1, KNBC, NBC1, NBC2, NBCe1-A, SLC4A5, hhNMC, pNBC | solute carrier family 4 (sodium bicarbonate cotransporter), member 4 |
C00018398
|
| 6607 | SMN2, BCD541, C-BCD541, GEMIN1, SMNC, TDRD16B | survival of motor neuron 2, centromeric |
C00018398
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (15)
| OMIM | preferred title | UniProt |
|---|---|---|
| #103780 | Alcohol dependence |
P14416
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #159900 | Myoclonic dystonia |
P14416
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
KEGG DISEASE (13)
| KEGG | name | UniProt |
|---|---|---|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|