PCIDB

KNApSAcK Metabolite C00018418

Metabolite

KNApSAcK Entry

id C00018418
Name Thiolactomycin / Antibiotic 2-200
CAS RN 82079-32-1
Standard InChI InChI=1S/C11H14O2S/c1-5-7(2)6-11(4)9(12)8(3)10(13)14-11/h5-6,12H,1H2,2-4H3/b7-6+/t11-/m1/s1
Standard InChI (Main Layer) InChI=1S/C11H14O2S/c1-5-7(2)6-11(4)9(12)8(3)10(13)14-11/h5-6,12H,1H2,2-4H3

Cluster

Phytochemical cluster
KCF-S cluster No. 3735

Link

ChEMBL

By standard InChI CHEMBL399043
By standard InChI Main Layer CHEMBL399043 CHEMBL248705

KEGG

By LinkDB C11165

CTD

By CAS RN C035068

Species

Summary

Plant class

class name count

Family

family name count
Nocardiaceae 1

List (1)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Nocardia sp. No. 2-200 1817 Nocardiaceae Bacteria

Human Protein / Gene in interaction

18 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 CHEMBL248705 CHEMBL1741321 (1)
1 / 0
P06746 DNA polymerase beta Enzyme CHEMBL399043 CHEMBL1614079 (1)
0 / 0
P49327 Fatty acid synthase Transferase CHEMBL399043 CHEMBL248705 CHEMBL828726 (2) CHEMBL863392 (1)
CHEMBL2169045 (2)
0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 CHEMBL248705 CHEMBL1741325 (1)
0 / 1
P54132 Bloom syndrome protein Enzyme CHEMBL399043 CHEMBL1614522 (1) CHEMBL1614067 (1)
1 / 2
Q9Y253 DNA polymerase eta Enzyme CHEMBL399043 CHEMBL1794569 (1)
1 / 1
P83916 Chromobox protein homolog 1 Unclassified protein CHEMBL399043 CHEMBL1738610 (1)
0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 CHEMBL248705 CHEMBL1741322 (1)
0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme CHEMBL248705 CHEMBL1613910 (1) CHEMBL1614227 (1)
3 / 3
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 CHEMBL248705 CHEMBL1741323 (1)
1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 CHEMBL248705 CHEMBL1741324 (1)
0 / 1
Q9UNA4 DNA polymerase iota Enzyme CHEMBL399043 CHEMBL1794483 (1)
0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme CHEMBL399043 CHEMBL1614283 (1) CHEMBL1614466 (1)
CHEMBL1614211 (1)
0 / 0
Q99549 M-phase phosphoprotein 8 Unclassified protein CHEMBL399043 CHEMBL1738402 (1)
0 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme CHEMBL399043 CHEMBL1614330 (1) CHEMBL1613829 (1)
CHEMBL1613928 (1)
0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme CHEMBL399043 CHEMBL1614364 (1)
1 / 1
Q13951 Core-binding factor subunit beta Unclassified protein CHEMBL399043 CHEMBL1613933 (1)
0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein CHEMBL399043 CHEMBL1613933 (1)
1 / 6

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (9)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#210900 Bloom syndrome; blm P54132
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (14)

KEGG disease name UniProt
H00036 Osteosarcoma P08684 (marker)
H01205 Coumarin resistance P11712 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00094 DNA repair defects P54132 (related)
H00296 Defects in RecQ helicases P54132 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H00063 Spinocerebellar ataxia (SCA) Q9NUW8 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)