PCIDB

KCF-S cluster No. 3735 (3 metabolites)

Plant Species

Cumulative plant class count

class name count

Cumulative family count

class name count
Streptomycetaceae 2
Nocardiaceae 1

KEGG BRITE br08003 External link 512

Categories (0)

br08003 Category # of metabolite

metabolites link (0)

br08003 Category KEGG ID KNApSAcK ID

Metabolite list (3)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		figure
C00017744 External link 512 U 68204
C048099
C00018418 External link 512 Thiolactomycin
/ Antibiotic 2-200
CHEMBL399043
CHEMBL248705
C035068
18 / 9 / 14
C00018483 External link 512 Thiotetromycin
/ Antibiotic OM 674
C037482

Human Protein / Gene in interactions

18 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00018418 1 / 0
P06746 DNA polymerase beta Enzyme C00018418 0 / 0
P49327 Fatty acid synthase Transferase C00018418 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00018418 0 / 1
P54132 Bloom syndrome protein Enzyme C00018418 1 / 2
Q9Y253 DNA polymerase eta Enzyme C00018418 1 / 1
P83916 Chromobox protein homolog 1 Unclassified protein C00018418 0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00018418 0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00018418 3 / 3
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00018418 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00018418 0 / 1
Q9UNA4 DNA polymerase iota Enzyme C00018418 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00018418 0 / 0
Q99549 M-phase phosphoprotein 8 Unclassified protein C00018418 0 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme C00018418 0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00018418 1 / 1
Q13951 Core-binding factor subunit beta Unclassified protein C00018418 0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein C00018418 1 / 4

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (9)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#210900 Bloom syndrome; blm P54132
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (14)

KEGG name UniProt
H00036 Osteosarcoma P08684 (marker)
H01205 Coumarin resistance P11712 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00094 DNA repair defects P54132 (related)
H00296 Defects in RecQ helicases P54132 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H00063 Spinocerebellar ataxia (SCA) Q9NUW8 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)