PCIDB

KNApSAcK Metabolite C00018785

Metabolite

KNApSAcK Entry

id C00018785
Name Pepstatin / NSC 272671 / Ahpatinin C / Pepstatin A / Procidin S 735A / Pepsin inhibitor S 735A
CAS RN 26305-03-3
Standard InChI InChI=1S/C34H63N5O9/c1-17(2)12-23(37-33(47)31(21(9)10)39-34(48)30(20(7)8)38-27(42)14-19(5)6)25(40)15-28(43)35-22(11)32(46)36-24(13-18(3)4)26(41)16-29(44)45/h17-26,30-31,40-41H,12-16H2,1-11H3,(H,35,43)(H,36,46)(H,37,47)(H,38,42)(H,39,48)(H,44,45)/t22-,23-,24-,25-,26-,30-,31-/m0/s1
Standard InChI (Main Layer) InChI=1S/C34H63N5O9/c1-17(2)12-23(37-33(47)31(21(9)10)39-34(48)30(20(7)8)38-27(42)14-19(5)6)25(40)15-28(43)35-22(11)32(46)36-24(13-18(3)4)26(41)16-29(44)45/h17-26,30-31,40-41H,12-16H2,1-11H3,(H,35,43)(H,36,46)(H,37,47)(H,38,42)(H,39,48)(H,44,45)

Cluster

Phytochemical cluster
KCF-S cluster No. 905

Link

ChEMBL

By standard InChI CHEMBL296588
By standard InChI Main Layer CHEMBL38526 CHEMBL296588 CHEMBL74864 CHEMBL263246 CHEMBL94014 CHEMBL122642 CHEMBL1478188

KEGG

By LinkDB

CTD

By CAS RN

Species

Summary

Plant class

class name count

Family

family name count
Streptomycetaceae 1

List (1)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Streptomyces testaceus 1883 Streptomycetaceae Bacteria

Human Protein / Gene in interaction

25 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 CHEMBL1478188 CHEMBL1741321 (1)
1 / 0
P49798 Regulator of G-protein signaling 4 Unclassified protein CHEMBL296588 CHEMBL1794499 (1)
2 / 0
Q99895 Chymotrypsin-C S1A CHEMBL296588 CHEMBL661266 (1)
0 / 2
P02545 Prelamin-A/C Unclassified protein CHEMBL1478188 CHEMBL1614544 (1)
11 / 10
P10828 Thyroid hormone receptor beta NR1A2 CHEMBL1478188 CHEMBL1613776 (1)
3 / 1
P09668 Pro-cathepsin H C1A CHEMBL296588 CHEMBL1021960 (1)
0 / 1
P0DJD9 Pepsin A-5 A1A CHEMBL296588 CHEMBL759819 (1)
0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 CHEMBL1478188 CHEMBL1741325 (1)
0 / 1
P11473 Vitamin D3 receptor NR1I1 CHEMBL296588 CHEMBL1794311 (1)
2 / 3
P07858 Cathepsin B C1A CHEMBL296588 CHEMBL1021958 (1)
0 / 1
P14091 Cathepsin E A1A CHEMBL296588 CHEMBL1043696 (1) CHEMBL1043703 (1)
CHEMBL1043705 (1) CHEMBL1043708 (1)
CHEMBL1043710 (1) CHEMBL1043712 (1)
CHEMBL2185512 (1)
0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme CHEMBL296588 CHEMBL1478188 CHEMBL1738606 (3)
0 / 0
O75496 Geminin Unclassified protein CHEMBL296588 CHEMBL2114843 (1)
0 / 0
P07339 Cathepsin D A1A CHEMBL296588 CHEMBL657347 (1) CHEMBL662654 (1)
CHEMBL661015 (1) CHEMBL869858 (1)
CHEMBL929232 (1) CHEMBL1021961 (1)
CHEMBL1043695 (1) CHEMBL1043702 (1)
CHEMBL1043704 (1) CHEMBL1043707 (1)
CHEMBL1043709 (1) CHEMBL1043711 (1)
CHEMBL2185513 (1)
1 / 2
P07711 Cathepsin L1 C1A CHEMBL296588 CHEMBL1021959 (1)
0 / 0
P00797 Renin A1A CHEMBL296588 CHEMBL94014 CHEMBL122642 CHEMBL764015 (1) CHEMBL795262 (1)
CHEMBL801594 (1) CHEMBL801596 (1)
CHEMBL801604 (1) CHEMBL801708 (1)
CHEMBL801668 (1) CHEMBL801673 (1)
CHEMBL806845 (1) CHEMBL806847 (1)
CHEMBL806860 (1) CHEMBL807519 (1)
CHEMBL872310 (1) CHEMBL883369 (1)
CHEMBL803244 (1) CHEMBL847095 (1)
CHEMBL847096 (1) CHEMBL872821 (1)
2 / 2
Q13443 Disintegrin and metalloproteinase domain-containing protein 9 M12B CHEMBL296588 CHEMBL1043697 (1)
1 / 1
P56817 Beta-secretase 1 A1A CHEMBL296588 CHEMBL653515 (1)
0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 CHEMBL1478188 CHEMBL1741322 (1)
0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 CHEMBL1478188 CHEMBL1741323 (1)
1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 CHEMBL1478188 CHEMBL1741324 (1)
0 / 1
P46063 ATP-dependent DNA helicase Q1 Enzyme CHEMBL296588 CHEMBL1613829 (1)
0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme CHEMBL296588 CHEMBL1738442 (1)
0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme CHEMBL296588 CHEMBL1614364 (1)
1 / 1
Q13148 TAR DNA-binding protein 43 Unclassified protein CHEMBL296588 CHEMBL2354287 (1)
1 / 1

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (26)

OMIM preferred title UniProt
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#610127 Ceroid lipofuscinosis, neuronal, 10; cln10 P07339
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#612775 Cone-rod dystrophy 9; cord9 Q13443
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#613092 Hyperuricemic nephropathy, familial juvenile, 2; hnfj2 P00797
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#267430 Renal tubular dysgenesis; rtd P00797
#275210 Restrictive dermopathy, lethal P02545
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473

KEGG DISEASE (27)

KEGG disease name UniProt
H00541 Uromodulin-associated kidney diseases P00797 (related)
H00575 Renal tubular dysgenesis P00797 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00149 Neuronal ceroid lipofuscinosis P07339 (related)
H00810 Progressive myoclonic epilepsy (PME) P07339 (related)
H00932 Tropical calcific pancreatitis P07858 (related)
Q99895 (related)
H00036 Osteosarcoma P08684 (marker)
H00408 Type I diabetes mellitus P09668 (related)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H01205 Coumarin resistance P11712 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00058 Amyotrophic lateral sclerosis (ALS) Q13148 (related)
H00481 Cone-rod dystrophy and cone dystrophy Q13443 (related)
H00933 Hereditary pancreatitis Q99895 (related)
H00063 Spinocerebellar ataxia (SCA) Q9NUW8 (related)