| class name | count |
|---|
| class name | count |
|---|---|
| Streptomycetaceae | 10 |
| br08003 Category | # of metabolite |
|---|
| br08003 Category | KEGG ID | KNApSAcK ID |
|---|
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
figure |
|---|---|---|---|---|---|---|
|
C00016617
|
YF 044P-D
|
C088534
|
|
|||
|
C00017793
|
WK 142A
|
|
||||
|
C00017794
|
Ahpatinin F
/ Pepstatin A |
|
||||
|
C00017795
|
WK 142B
|
|
||||
|
C00017969
|
Butyl pepstatin
/ 1-[N-(1-Oxobutyl)-L-valine]-pepstatin A |
|
||||
|
C00017971
|
Hydroxypepstatin A
/ 4-L-Serine-pepstatin A |
C013049
|
|
|||
|
C00018785
|
Pepstatin
/ NSC 272671 / Ahpatinin C / Pepstatin A / Procidin S 735A / Pepsin inhibitor S 735A |
CHEMBL38526
CHEMBL296588 CHEMBL74864 CHEMBL263246 CHEMBL94014 CHEMBL122642 CHEMBL1478188 |
25 / 26 / 27 |
|
||
|
C00018845
|
Pepstatin B
|
|
||||
|
C00018846
|
Pepstatin C
|
|
||||
|
C00018847
|
Pepstanone A
|
C003067
|
|
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00018785 | 1 / 0 |
| P49798 | Regulator of G-protein signaling 4 | Unclassified protein | C00018785 | 2 / 0 |
| Q99895 | Chymotrypsin-C | S1A | C00018785 | 0 / 2 |
| P02545 | Prelamin-A/C | Unclassified protein | C00018785 | 11 / 10 |
| P10828 | Thyroid hormone receptor beta | NR1A2 | C00018785 | 3 / 1 |
| P09668 | Pro-cathepsin H | C1A | C00018785 | 0 / 1 |
| P0DJD9 | Pepsin A-5 | A1A | C00018785 | 0 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00018785 | 0 / 1 |
| P11473 | Vitamin D3 receptor | NR1I1 | C00018785 | 2 / 3 |
| P07858 | Cathepsin B | C1A | C00018785 | 0 / 1 |
| P14091 | Cathepsin E | A1A | C00018785 | 0 / 0 |
| Q92830 | Histone acetyltransferase KAT2A | Enzyme | C00018785 | 0 / 0 |
| O75496 | Geminin | Unclassified protein | C00018785 | 0 / 0 |
| P07339 | Cathepsin D | A1A | C00018785 | 1 / 2 |
| P07711 | Cathepsin L1 | C1A | C00018785 | 0 / 0 |
| P00797 | Renin | A1A | C00018785 | 2 / 2 |
| Q13443 | Disintegrin and metalloproteinase domain-containing protein 9 | M12B | C00018785 | 1 / 1 |
| P56817 | Beta-secretase 1 | A1A | C00018785 | 0 / 0 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00018785 | 0 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00018785 | 1 / 1 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00018785 | 0 / 1 |
| P46063 | ATP-dependent DNA helicase Q1 | Enzyme | C00018785 | 0 / 0 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00018785 | 0 / 0 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00018785 | 1 / 1 |
| Q13148 | TAR DNA-binding protein 43 | Unclassified protein | C00018785 | 1 / 1 |
| OMIM | preferred title | UniProt |
|---|---|---|
| #612069 | Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 |
Q13148
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #610127 | Ceroid lipofuscinosis, neuronal, 10; cln10 |
P07339
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #612775 | Cone-rod dystrophy 9; cord9 |
Q13443
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #613092 | Hyperuricemic nephropathy, familial juvenile, 2; hnfj2 |
P00797
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
| #267430 | Renal tubular dysgenesis; rtd |
P00797
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #604906 | Schizophrenia 9; sczd9 |
P49798
|
| #181500 | Schizophrenia; sczd |
P49798
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
| #188570 | Thyroid hormone resistance, generalized, autosomal dominant; grth |
P10828
|
| #274300 | Thyroid hormone resistance, generalized, autosomal recessive; grth |
P10828
|
| #145650 | Thyroid hormone resistance, selective pituitary; prth |
P10828
|
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
| KEGG | name | UniProt |
|---|---|---|
| H00541 | Uromodulin-associated kidney diseases |
P00797
(related)
|
| H00575 | Renal tubular dysgenesis |
P00797
(related)
|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00149 | Neuronal ceroid lipofuscinosis |
P07339
(related)
|
| H00810 | Progressive myoclonic epilepsy (PME) |
P07339
(related)
|
| H00932 | Tropical calcific pancreatitis |
P07858
(related)
Q99895 (related) |
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H00408 | Type I diabetes mellitus |
P09668
(related)
|
| H00249 | Thyroid hormone resistance syndrome |
P10828
(related)
|
| H00342 | Tuberculosis |
P11473
(related)
|
| H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
| H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
Q13148
(related)
|
| H00481 | Cone-rod dystrophy and cone dystrophy |
Q13443
(related)
|
| H00933 | Hereditary pancreatitis |
Q99895
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q9NUW8
(related)
|