KNApSAcK Metabolite C00018795
Metabolite
KNApSAcK Entry
| id | C00018795 |
|---|---|
| Name | NSC 212518 / NSC 122750 / Geldanamycin |
| CAS RN | 30562-34-6 |
| Standard InChI | InChI=1S/C29H40N2O9/c1-15-11-19-25(34)20(14-21(32)27(19)39-7)31-28(35)16(2)9-8-10-22(37-5)26(40-29(30)36)18(4)13-17(3)24(33)23(12-15)38-6/h8-10,13-15,17,22-24,26,33H,11-12H2,1-7H3,(H2,30,36)(H,31,35)/b10-8-,16-9+,18-13+/t15-,17+,22+,23+,24-,26+/m1/s1 |
| Standard InChI (Main Layer) | InChI=1S/C29H40N2O9/c1-15-11-19-25(34)20(14-21(32)27(19)39-7)31-28(35)16(2)9-8-10-22(37-5)26(40-29(30)36)18(4)13-17(3)24(33)23(12-15)38-6/h8-10,13-15,17,22-24,26,33H,11-12H2,1-7H3,(H2,30,36)(H,31,35) |
Cluster
| Phytochemical cluster | |
|---|---|
| KCF-S cluster | No. 2569 |
Link
ChEMBL
| By standard InChI | CHEMBL278315 |
|---|---|
| By standard InChI Main Layer | CHEMBL278315 CHEMBL182055 CHEMBL1165003 CHEMBL1594212 |
KEGG
| By LinkDB | C11222 |
|---|
CTD
| By CAS RN | C001277 |
|---|
Species
Summary
Plant class
| class name | count |
|---|
Family
| family name | count |
|---|---|
| Streptomycetaceae | 1 |
List (1)
* NCBI
| KNApSAcK organism | *ID | *family | *plant class | *kingdom |
|---|---|---|---|---|
| Streptomyces hygroscopicus var. enhygrus var. nov. | 1883 | Streptomycetaceae | Bacteria |
Human Protein / Gene in interaction
31 ChEMBL Protein in interactions
| accession | description | class description | compound | assay ID (# of activities) |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|---|
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | CHEMBL278315 |
CHEMBL1780620
(1)
|
1 / 0 |
| Q9P1W9 | Serine/threonine-protein kinase pim-2 | Pim | CHEMBL278315 |
CHEMBL1004482
(1)
|
0 / 0 |
| Q12809 | Potassium voltage-gated channel subfamily H member 2 | KCNH, Kv10-12.x (Ether-a-go-go) | CHEMBL278315 |
CHEMBL1780626
(1)
|
2 / 2 |
| Q15759 | Mitogen-activated protein kinase 11 | p38 | CHEMBL278315 |
CHEMBL1004486
(1)
|
0 / 0 |
| Q9H2G2 | STE20-like serine/threonine-protein kinase | STE serine/threonine protein kinase SLK subfamily | CHEMBL278315 |
CHEMBL1004491
(1)
|
0 / 0 |
| Q16659 | Mitogen-activated protein kinase 6 | CMGC serine/threonine protein kinase ERK3 subfamily | CHEMBL278315 |
CHEMBL1004485
(1)
|
0 / 0 |
| Q16543 | Hsp90 co-chaperone Cdc37 | Unclassified protein | CHEMBL278315 |
CHEMBL1803252
(1)
|
0 / 0 |
| P11309 | Serine/threonine-protein kinase pim-1 | Pim | CHEMBL278315 |
CHEMBL1004481
(1)
|
0 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | CHEMBL278315 |
CHEMBL1780619
(1)
|
0 / 1 |
| O00444 | Serine/threonine-protein kinase PLK4 | PLK serine/threonine protein kinase subfamily | CHEMBL278315 |
CHEMBL1004495
(1)
|
0 / 0 |
| Q9NQU5 | Serine/threonine-protein kinase PAK 6 | STE serine/threonine protein kinase PAKB subfamily | CHEMBL278315 |
CHEMBL1004496
(1)
|
0 / 0 |
| O75828 | Carbonyl reductase [NADPH] 3 | Enzyme | CHEMBL278315 |
CHEMBL1004501
(1)
CHEMBL1004502
(1)
CHEMBL1004503 (1) |
0 / 0 |
| P11473 | Vitamin D3 receptor | NR1I1 | CHEMBL278315 CHEMBL1594212 |
CHEMBL1794311
(2)
|
2 / 3 |
| Q13188 | Serine/threonine-protein kinase 3 | STE serine/threonine protein kinase MST subfamily | CHEMBL278315 |
CHEMBL1004490
(1)
|
0 / 0 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | CHEMBL1594212 |
CHEMBL1614458
(1)
|
0 / 0 |
| P07332 | Tyrosine-protein kinase Fes/Fps | Fer | CHEMBL278315 |
CHEMBL1004488
(1)
|
0 / 0 |
| P16152 | Carbonyl reductase [NADPH] 1 | Enzyme | CHEMBL278315 |
CHEMBL1004498
(1)
CHEMBL1004499
(1)
CHEMBL1004500 (1) |
0 / 0 |
| P84022 | Mothers against decapentaplegic homolog 3 | Unclassified protein | CHEMBL1594212 |
CHEMBL1794584
(1)
|
2 / 0 |
| Q99683 | Mitogen-activated protein kinase kinase kinase 5 | Ste11 | CHEMBL278315 |
CHEMBL1004489
(1)
|
0 / 0 |
| P11021 | 78 kDa glucose-regulated protein | Unclassified protein | CHEMBL278315 CHEMBL1594212 |
CHEMBL1963893
(2)
|
0 / 0 |
| P52564 | Dual specificity mitogen-activated protein kinase kinase 6 | Ste7 | CHEMBL278315 |
CHEMBL1004493
(1)
|
0 / 0 |
| O14976 | Cyclin-G-associated kinase | NAK serine/threonine protein kinase subfamily | CHEMBL278315 |
CHEMBL1004484
(1)
|
0 / 0 |
| O94804 | Serine/threonine-protein kinase 10 | STE serine/threonine protein kinase SLK subfamily | CHEMBL278315 |
CHEMBL1004492
(1)
|
1 / 0 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | CHEMBL278315 |
CHEMBL2114870
(1)
CHEMBL2114872
(1)
CHEMBL2114877 (1) CHEMBL2114909 (1) CHEMBL2114929 (1) |
0 / 0 |
| P08238 | Heat shock protein HSP 90-beta | Other cytosolic protein | CHEMBL278315 |
CHEMBL695094
(1)
CHEMBL715092
(1)
CHEMBL871130 (1) CHEMBL943966 (1) CHEMBL1021924 (1) CHEMBL1020372 (1) CHEMBL1100065 (1) CHEMBL1100066 (1) CHEMBL1664649 (1) CHEMBL1664650 (1) CHEMBL1664652 (1) CHEMBL1664660 (1) CHEMBL1925997 (1) CHEMBL2188544 (1) |
0 / 0 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | CHEMBL278315 |
CHEMBL1780621
(1)
|
0 / 1 |
| O75164 | Lysine-specific demethylase 4A | Enzyme | CHEMBL1594212 |
CHEMBL1737991
(1)
|
0 / 0 |
| Q9HCP0 | Casein kinase I isoform gamma-1 | Ck1 | CHEMBL278315 |
CHEMBL1004494
(1)
|
0 / 0 |
| P07900 | Heat shock protein HSP 90-alpha | Other cytosolic protein | CHEMBL278315 |
CHEMBL695094
(1)
CHEMBL693501
(1)
CHEMBL693502 (1) CHEMBL715092 (1) CHEMBL832187 (1) CHEMBL871130 (1) CHEMBL943966 (1) CHEMBL944009 (1) CHEMBL1664662 (1) CHEMBL1763722 (1) CHEMBL1780615 (1) CHEMBL1810576 (1) |
0 / 0 |
| Q86V86 | Serine/threonine-protein kinase pim-3 | Pim | CHEMBL278315 |
CHEMBL1004483
(1)
|
0 / 0 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | CHEMBL1594212 |
CHEMBL1738442
(1)
|
0 / 0 |
CTD interaction (105)
| compound | gene | gene name | gene description | interaction | interaction type | form |
reference
pmid |
|---|---|---|---|---|---|---|---|
| C001277 | 196 |
AHR
bHLHe76 |
aryl hydrocarbon receptor | benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [geldanamycin results in decreased expression of AHR protein] |
decreases expression
/ decreases reaction |
protein |
20057149
|
| C001277 | 196 |
AHR
bHLHe76 |
aryl hydrocarbon receptor | geldanamycin results in decreased expression of AHR protein |
decreases expression
|
protein |
20057149
|
| C001277 | 196 |
AHR
bHLHe76 |
aryl hydrocarbon receptor | geldanamycin results in increased localization of AHR protein |
increases localization
|
protein |
12237327
|
| C001277 | 207 |
AKT1
AKT CWS6 PKB PKB-ALPHA PRKBA RAC RAC-ALPHA |
v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) | [geldanamycin co-treated with bortezomib] results in decreased expression of AKT1 protein |
affects cotreatment
/ decreases expression |
protein |
15781649
|
| C001277 | 207 |
AKT1
AKT CWS6 PKB PKB-ALPHA PRKBA RAC RAC-ALPHA |
v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) | geldanamycin inhibits the reaction [Tretinoin results in increased phosphorylation of AKT1 protein] |
decreases reaction
/ increases phosphorylation |
protein |
17293044
|
| C001277 | 207 |
AKT1
AKT CWS6 PKB PKB-ALPHA PRKBA RAC RAC-ALPHA |
v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) | geldanamycin results in decreased expression of and results in decreased phosphorylation of AKT1 protein |
decreases expression
/ decreases phosphorylation |
protein |
19167484
|
| C001277 | 207 |
AKT1
AKT CWS6 PKB PKB-ALPHA PRKBA RAC RAC-ALPHA |
v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) | geldanamycin results in decreased phosphorylation of AKT1 protein |
decreases phosphorylation
|
protein |
17293044
|
| C001277 | 596 |
BCL2
Bcl-2 PPP1R50 |
B-cell CLL/lymphoma 2 | [geldanamycin co-treated with bortezomib] results in decreased expression of BCL2 protein |
affects cotreatment
/ decreases expression |
protein |
15781649
|
| C001277 | 598 |
BCL2L1
BCL-XL/S BCL2L BCLX BCLXL BCLXS Bcl-X PPP1R52 bcl-xL bcl-xS |
BCL2-like 1 | BCL2L1 protein results in decreased susceptibility to geldanamycin |
decreases response to substance
|
protein |
15781649
|
| C001277 | 598 |
BCL2L1
BCL-XL/S BCL2L BCLX BCLXL BCLXS Bcl-X PPP1R52 bcl-xL bcl-xS |
BCL2-like 1 | [geldanamycin co-treated with bortezomib] results in decreased expression of BCL2L1 protein |
affects cotreatment
/ decreases expression |
protein |
15781649
|
| C001277 | 329 |
BIRC2
API1 HIAP2 Hiap-2 MIHB RNF48 c-IAP1 cIAP1 |
baculoviral IAP repeat containing 2 | [geldanamycin co-treated with bortezomib] results in decreased expression of BIRC2 protein |
affects cotreatment
/ decreases expression |
protein |
15781649
|
| C001277 | 836 |
CASP3
CPP32 CPP32B SCA-1 |
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) | geldanamycin inhibits the reaction [Demecolcine results in increased activity of CASP3 protein] |
decreases reaction
/ increases activity |
protein |
12530016
|
| C001277 | 836 |
CASP3
CPP32 CPP32B SCA-1 |
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) | geldanamycin inhibits the reaction [Nicotine results in increased activity of CASP3 protein] |
decreases reaction
/ increases activity |
protein |
12115584
|
| C001277 | 836 |
CASP3
CPP32 CPP32B SCA-1 |
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) | geldanamycin results in increased activity of CASP3 protein |
increases activity
|
protein |
14576064
|
| C001277 | 842 |
CASP9
APAF-3 APAF3 ICE-LAP6 MCH6 PPP1R56 |
caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) | geldanamycin inhibits the reaction [Doxorubicin results in increased cleavage of CASP9 protein] |
decreases reaction
/ increases cleavage |
protein |
16311509
|
| C001277 | 595 |
CCND1
BCL1 D11S287E PRAD1 U21B31 |
cyclin D1 | [geldanamycin co-treated with bortezomib] results in decreased expression of CCND1 protein |
affects cotreatment
/ decreases expression |
protein |
15781649
|
| C001277 | 595 |
CCND1
BCL1 D11S287E PRAD1 U21B31 |
cyclin D1 | geldanamycin results in decreased expression of CCND1 mRNA |
decreases expression
|
mRNA |
17959518
|
| C001277 | 11140 |
CDC37
P50CDC37 |
cell division cycle 37 | geldanamycin inhibits the reaction [HSP90AA1 protein binds to SRC protein binds to CDC37 protein] |
affects binding
/ decreases reaction |
protein |
17223712
|
| C001277 | 11140 |
CDC37
P50CDC37 |
cell division cycle 37 | geldanamycin inhibits the reaction [Tetrachlorodibenzodioxin affects the localization of CDC37 protein] |
affects localization
/ decreases reaction |
protein |
17223712
|
| C001277 | 999 |
CDH1
Arc-1 CD324 CDHE ECAD LCAM UVO |
cadherin 1, type 1, E-cadherin (epithelial) | geldanamycin promotes the reaction [CDH1 protein binds to CTNNB1 protein] |
affects binding
/ increases reaction |
protein |
17024233
|
| C001277 | 999 |
CDH1
Arc-1 CD324 CDHE ECAD LCAM UVO |
cadherin 1, type 1, E-cadherin (epithelial) | geldanamycin results in increased expression of CDH1 protein |
increases expression
|
protein |
17024233
|
| C001277 | 999 |
CDH1
Arc-1 CD324 CDHE ECAD LCAM UVO |
cadherin 1, type 1, E-cadherin (epithelial) | IL24 protein promotes the reaction [geldanamycin promotes the reaction [CDH1 protein binds to CTNNB1 protein]] |
affects binding
/ increases reaction |
protein |
17024233
|
| C001277 | 999 |
CDH1
Arc-1 CD324 CDHE ECAD LCAM UVO |
cadherin 1, type 1, E-cadherin (epithelial) | IL24 protein promotes the reaction [geldanamycin results in increased expression of CDH1 protein] |
increases expression
/ increases reaction |
protein |
17024233
|
| C001277 | 1080 |
CFTR
ABC35 ABCC7 CF CFTR/MRP MRP7 TNR-CFTR dJ760C5.1 |
cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) (EC:3.6.3.49) | geldanamycin promotes the reaction [5-butyl-7-chloro-6-hydroxybenzo(c)quinolizinium inhibits the reaction [CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]]] |
affects cotreatment
/ decreases reaction / increases reaction / increases transport |
protein |
18230692
|
| C001277 | 1080 |
CFTR
ABC35 ABCC7 CF CFTR/MRP MRP7 TNR-CFTR dJ760C5.1 |
cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) (EC:3.6.3.49) | geldanamycin promotes the reaction [miglustat inhibits the reaction [CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]]] |
affects cotreatment
/ decreases reaction / increases reaction / increases transport |
protein |
18230692
|
| C001277 | 1080 |
CFTR
ABC35 ABCC7 CF CFTR/MRP MRP7 TNR-CFTR dJ760C5.1 |
cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) (EC:3.6.3.49) | geldanamycin promotes the reaction [miglustat results in increased activity of CFTR protein mutant form] |
increases activity
/ increases reaction |
protein |
18230692
|
| C001277 | 1147 |
CHUK
IKBKA IKK-alpha IKK1 IKKA NFKBIKA TCF16 |
conserved helix-loop-helix ubiquitous kinase (EC:2.7.11.10) | geldanamycin results in increased degradation of CHUK protein |
increases degradation
|
protein |
15930313
|
| C001277 | 1499 |
CTNNB1
CTNNB MRD19 armadillo |
catenin (cadherin-associated protein), beta 1, 88kDa | geldanamycin promotes the reaction [CDH1 protein binds to CTNNB1 protein] |
affects binding
/ increases reaction |
protein |
17024233
|
| C001277 | 1499 |
CTNNB1
CTNNB MRD19 armadillo |
catenin (cadherin-associated protein), beta 1, 88kDa | IL24 protein promotes the reaction [geldanamycin promotes the reaction [CDH1 protein binds to CTNNB1 protein]] |
affects binding
/ increases reaction |
protein |
17024233
|
| C001277 | 1543 |
CYP1A1
AHH AHRR CP11 CYP1 P1-450 P450-C P450DX |
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) | geldanamycin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA] |
decreases reaction
/ increases expression |
mRNA |
20057149
|
| C001277 | 1956 |
EGFR
ERBB ERBB1 HER1 PIG61 mENA |
epidermal growth factor receptor (EC:2.7.10.1) | geldanamycin promotes the reaction [Sulfasalazine results in decreased expression of EGFR protein] |
decreases expression
/ increases reaction |
protein |
20007406
|
| C001277 | 1956 |
EGFR
ERBB ERBB1 HER1 PIG61 mENA |
epidermal growth factor receptor (EC:2.7.10.1) | geldanamycin results in decreased expression of EGFR protein |
decreases expression
|
protein |
20007406
|
| C001277 | 2064 |
ERBB2
CD340 HER-2 HER-2/neu HER2 MLN_19 NEU NGL TKR1 |
v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (EC:2.7.10.1) | [geldanamycin binds to HSP90B1 protein] inhibits the reaction [HSP90B1 protein binds to ERBB2 protein] |
affects binding
/ decreases reaction |
protein |
8617772
|
| C001277 | 2064 |
ERBB2
CD340 HER-2 HER-2/neu HER2 MLN_19 NEU NGL TKR1 |
v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (EC:2.7.10.1) | geldanamycin results in increased degradation of ERBB2 protein |
increases degradation
|
protein |
8617772
11071886 17959518 |
| C001277 | 2099 |
ESR1
ER ESR ESRA ESTRR Era NR3A1 |
estrogen receptor 1 | geldanamycin inhibits the reaction [Estradiol binds to ESR1 protein] |
affects binding
/ decreases reaction |
protein |
11448926
|
| C001277 | 2099 |
ESR1
ER ESR ESRA ESTRR Era NR3A1 |
estrogen receptor 1 | geldanamycin promotes the reaction [ESR1 protein binds to STUB1 protein] |
affects binding
/ increases reaction |
protein |
16037132
|
| C001277 | 2099 |
ESR1
ER ESR ESRA ESTRR Era NR3A1 |
estrogen receptor 1 | geldanamycin results in decreased expression of ESR1 protein |
decreases expression
|
protein |
11448926
|
| C001277 | 2099 |
ESR1
ER ESR ESRA ESTRR Era NR3A1 |
estrogen receptor 1 | geldanamycin results in decreased stability of ESR1 protein |
decreases stability
|
protein |
11448926
|
| C001277 | 2099 |
ESR1
ER ESR ESRA ESTRR Era NR3A1 |
estrogen receptor 1 | geldanamycin results in increased degradation of ESR1 protein |
increases degradation
|
protein |
16037132
|
| C001277 | 2099 |
ESR1
ER ESR ESRA ESTRR Era NR3A1 |
estrogen receptor 1 | STUB1 protein promotes the reaction [geldanamycin results in increased degradation of ESR1 protein] |
increases degradation
/ increases reaction |
protein |
16037132
|
| C001277 | 2252 |
FGF7
HBGF-7 KGF |
fibroblast growth factor 7 | geldanamycin inhibits the reaction [ammonium trichloro(dioxoethylene-O,O'-)tellurate results in increased expression of FGF7 protein] |
decreases reaction
/ increases expression |
protein |
14656992
|
| C001277 | 3091 |
HIF1A
HIF-1A HIF-1alpha HIF1 HIF1-ALPHA MOP1 PASD8 bHLHe78 |
hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [geldanamycin results in increased degradation of HIF1A protein] |
decreases reaction
/ increases degradation |
protein |
11980636
|
| C001277 | 3091 |
HIF1A
HIF-1A HIF-1alpha HIF1 HIF1-ALPHA MOP1 PASD8 bHLHe78 |
hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | geldanamycin inhibits the reaction [cobaltous chloride results in increased expression of HIF1A protein] |
decreases reaction
/ increases expression |
protein |
12811834
|
| C001277 | 3091 |
HIF1A
HIF-1A HIF-1alpha HIF1 HIF1-ALPHA MOP1 PASD8 bHLHe78 |
hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | geldanamycin results in decreased expression of HIF1A protein |
decreases expression
|
protein |
14726529
15319539 16432534 |
| C001277 | 3091 |
HIF1A
HIF-1A HIF-1alpha HIF1 HIF1-ALPHA MOP1 PASD8 bHLHe78 |
hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | geldanamycin results in increased degradation of HIF1A protein |
increases degradation
|
protein |
11980636
|
| C001277 | 3091 |
HIF1A
HIF-1A HIF-1alpha HIF1 HIF1-ALPHA MOP1 PASD8 bHLHe78 |
hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | lactacystin inhibits the reaction [geldanamycin results in increased degradation of HIF1A protein] |
decreases reaction
/ increases degradation |
protein |
11980636
|
| C001277 | 3248 |
HPGD
15-PGDH PGDH PGDH1 PHOAR1 SDR36C1 |
hydroxyprostaglandin dehydrogenase 15-(NAD) (EC:1.1.1.141) | geldanamycin inhibits the reaction [Dexamethasone results in increased expression of and results in increased activity of HPGD protein] |
decreases reaction
/ increases activity / increases expression |
protein |
15680906
|
| C001277 | 3297 |
HSF1
HSTF1 |
heat shock transcription factor 1 | geldanamycin results in increased phosphorylation of and results in increased activity of HSF1 protein |
increases activity
/ increases phosphorylation |
protein |
10632574
|
| C001277 | 692420 | geldanamycin results in decreased activity of HSP90 protein |
decreases activity
|
protein |
15319539
|
||
| C001277 | 3320 |
HSP90AA1
EL52 HSP86 HSP89A HSP90A HSP90N HSPC1 HSPCA HSPCAL1 HSPCAL4 HSPN Hsp89 Hsp90 LAP2 |
heat shock protein 90kDa alpha (cytosolic), class A member 1 | geldanamycin inhibits the reaction [HSP90AA1 protein binds to SRC protein binds to CDC37 protein] |
affects binding
/ decreases reaction |
protein |
17223712
|
| C001277 | 3320 |
HSP90AA1
EL52 HSP86 HSP89A HSP90A HSP90N HSPC1 HSPCA HSPCAL1 HSPCAL4 HSPN Hsp89 Hsp90 LAP2 |
heat shock protein 90kDa alpha (cytosolic), class A member 1 | geldanamycin inhibits the reaction [KCNH2 protein binds to HSP90AA1 protein] |
affects binding
/ decreases reaction |
protein |
12775586
|
| C001277 | 7184 |
HSP90B1
ECGP GP96 GRP94 TRA1 |
heat shock protein 90kDa beta (Grp94), member 1 | geldanamycin binds to HSP90B1 protein |
affects binding
|
protein |
8617772
|
| C001277 | 7184 |
HSP90B1
ECGP GP96 GRP94 TRA1 |
heat shock protein 90kDa beta (Grp94), member 1 | [geldanamycin binds to HSP90B1 protein] inhibits the reaction [HSP90B1 protein binds to ERBB2 protein] |
affects binding
/ decreases reaction |
protein |
8617772
|
| C001277 | 3303 |
HSPA1A
HSP70-1 HSP70-1A HSP70I HSP72 HSPA1 |
heat shock 70kDa protein 1A | geldanamycin results in increased expression of HSPA1A protein |
increases expression
|
protein |
11448926
|
| C001277 | 3308 |
HSPA4
APG-2 HS24/P52 HSPH2 RY hsp70 hsp70RY |
heat shock 70kDa protein 4 | geldanamycin results in increased expression of HSPA4 protein |
increases expression
|
protein |
16311509
|
| C001277 | 3308 |
HSPA4
APG-2 HS24/P52 HSPH2 RY hsp70 hsp70RY |
heat shock 70kDa protein 4 | [geldanamycin results in increased expression of HSPA4 protein] which results in decreased susceptibility to Doxorubicin |
decreases response to substance
/ increases expression |
protein |
16311509
|
| C001277 | 3309 |
HSPA5
BIP GRP78 MIF2 |
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | bortezomib promotes the reaction [geldanamycin results in increased expression of HSPA5 protein] |
increases expression
/ increases reaction |
protein |
15141013
|
| C001277 | 3309 |
HSPA5
BIP GRP78 MIF2 |
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | geldanamycin affects the expression of HSPA5 protein |
affects expression
|
protein |
14576064
|
| C001277 | 3309 |
HSPA5
BIP GRP78 MIF2 |
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | geldanamycin promotes the reaction [bortezomib results in increased expression of HSPA5 protein] |
increases expression
/ increases reaction |
protein |
15141013
|
| C001277 | 3309 |
HSPA5
BIP GRP78 MIF2 |
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | geldanamycin results in increased expression of HSPA5 protein |
increases expression
|
protein |
15141013
|
| C001277 | 3064 |
HTT
HD IT15 |
huntingtin | geldanamycin inhibits the reaction [HTT protein binds to HTT protein] |
affects binding
/ decreases reaction |
protein |
11406612
|
| C001277 | 11009 |
IL24
C49A FISP IL10B MDA7 MOB5 ST16 |
interleukin 24 | IL24 protein promotes the reaction [geldanamycin promotes the reaction [CDH1 protein binds to CTNNB1 protein]] |
affects binding
/ increases reaction |
protein |
17024233
|
| C001277 | 11009 |
IL24
C49A FISP IL10B MDA7 MOB5 ST16 |
interleukin 24 | IL24 protein promotes the reaction [geldanamycin results in increased expression of CDH1 protein] |
increases expression
/ increases reaction |
protein |
17024233
|
| C001277 | 3576 |
IL8
CXCL8 GCP-1 GCP1 LECT LUCT LYNAP MDNCF MONAP NAF NAP-1 NAP1 |
interleukin 8 | geldanamycin inhibits the reaction [TNF protein results in increased expression of IL8 mRNA] |
decreases reaction
/ increases expression |
mRNA |
11472980
|
| C001277 | 3576 |
IL8
CXCL8 GCP-1 GCP1 LECT LUCT LYNAP MDNCF MONAP NAF NAP-1 NAP1 |
interleukin 8 | geldanamycin inhibits the reaction [TNF protein results in increased expression of IL8 protein] |
decreases reaction
/ increases expression |
protein |
11472980
|
| C001277 | 3757 |
KCNH2
ERG1 HERG HERG1 Kv11.1 LQT2 SQT1 |
potassium voltage-gated channel, subfamily H (eag-related), member 2 | geldanamycin affects the localization of KCNH2 protein |
affects localization
|
protein |
12775586
|
| C001277 | 3757 |
KCNH2
ERG1 HERG HERG1 Kv11.1 LQT2 SQT1 |
potassium voltage-gated channel, subfamily H (eag-related), member 2 | geldanamycin inhibits the reaction [KCNH2 protein binds to HSP90AA1 protein] |
affects binding
/ decreases reaction |
protein |
12775586
|
| C001277 | 3757 |
KCNH2
ERG1 HERG HERG1 Kv11.1 LQT2 SQT1 |
potassium voltage-gated channel, subfamily H (eag-related), member 2 | geldanamycin results in decreased activity of KCNH2 protein |
decreases activity
|
protein |
12775586
|
| C001277 | 3757 |
KCNH2
ERG1 HERG HERG1 Kv11.1 LQT2 SQT1 |
potassium voltage-gated channel, subfamily H (eag-related), member 2 | geldanamycin results in decreased expression of KCNH2 protein modified form |
decreases expression
|
protein |
12775586
|
| C001277 | 3757 |
KCNH2
ERG1 HERG HERG1 Kv11.1 LQT2 SQT1 |
potassium voltage-gated channel, subfamily H (eag-related), member 2 | geldanamycin results in increased degradation of KCNH2 protein |
increases degradation
|
protein |
12775586
|
| C001277 | 5604 |
MAP2K1
CFC3 MAPKK1 MEK1 MKK1 PRKMK1 |
mitogen-activated protein kinase kinase 1 (EC:2.7.12.2) | geldanamycin results in decreased phosphorylation of MAP2K1 protein |
decreases phosphorylation
|
protein |
19167484
|
| C001277 | 5605 |
MAP2K2
CFC4 MAPKK2 MEK2 MKK2 PRKMK2 |
mitogen-activated protein kinase kinase 2 (EC:2.7.12.2) | geldanamycin results in decreased phosphorylation of MAP2K2 protein |
decreases phosphorylation
|
protein |
19167484
|
| C001277 | 5594 |
MAPK1
ERK ERK2 ERT1 MAPK2 P42MAPK PRKM1 PRKM2 p38 p40 p41 p41mapk |
mitogen-activated protein kinase 1 (EC:2.7.11.24) | geldanamycin inhibits the reaction [Dieldrin results in increased phosphorylation of MAPK1 protein] |
decreases reaction
/ increases phosphorylation |
protein |
15888667
|
| C001277 | 5594 |
MAPK1
ERK ERK2 ERT1 MAPK2 P42MAPK PRKM1 PRKM2 p38 p40 p41 p41mapk |
mitogen-activated protein kinase 1 (EC:2.7.11.24) | geldanamycin inhibits the reaction [Endosulfan results in increased phosphorylation of MAPK1 protein] |
decreases reaction
/ increases phosphorylation |
protein |
15888667
|
| C001277 | 5594 |
MAPK1
ERK ERK2 ERT1 MAPK2 P42MAPK PRKM1 PRKM2 p38 p40 p41 p41mapk |
mitogen-activated protein kinase 1 (EC:2.7.11.24) | geldanamycin inhibits the reaction [Heptachlor results in increased phosphorylation of MAPK1 protein] |
decreases reaction
/ increases phosphorylation |
protein |
15888667
|
| C001277 | 5594 |
MAPK1
ERK ERK2 ERT1 MAPK2 P42MAPK PRKM1 PRKM2 p38 p40 p41 p41mapk |
mitogen-activated protein kinase 1 (EC:2.7.11.24) | geldanamycin inhibits the reaction [Lindane results in increased phosphorylation of MAPK1 protein] |
decreases reaction
/ increases phosphorylation |
protein |
15888667
|
| C001277 | 5594 |
MAPK1
ERK ERK2 ERT1 MAPK2 P42MAPK PRKM1 PRKM2 p38 p40 p41 p41mapk |
mitogen-activated protein kinase 1 (EC:2.7.11.24) | geldanamycin inhibits the reaction [Tretinoin results in increased phosphorylation of MAPK1 protein] |
decreases reaction
/ increases phosphorylation |
protein |
17293044
|
| C001277 | 5594 |
MAPK1
ERK ERK2 ERT1 MAPK2 P42MAPK PRKM1 PRKM2 p38 p40 p41 p41mapk |
mitogen-activated protein kinase 1 (EC:2.7.11.24) | geldanamycin results in decreased phosphorylation of MAPK1 protein |
decreases phosphorylation
|
protein |
17293044
19167484 |
| C001277 | 5595 |
MAPK3
ERK-1 ERK1 ERT2 HS44KDAP HUMKER1A P44ERK1 P44MAPK PRKM3 p44-ERK1 p44-MAPK |
mitogen-activated protein kinase 3 (EC:2.7.11.24) | geldanamycin inhibits the reaction [Dieldrin results in increased phosphorylation of MAPK3 protein] |
decreases reaction
/ increases phosphorylation |
protein |
15888667
|
| C001277 | 5595 |
MAPK3
ERK-1 ERK1 ERT2 HS44KDAP HUMKER1A P44ERK1 P44MAPK PRKM3 p44-ERK1 p44-MAPK |
mitogen-activated protein kinase 3 (EC:2.7.11.24) | geldanamycin inhibits the reaction [Endosulfan results in increased phosphorylation of MAPK3 protein] |
decreases reaction
/ increases phosphorylation |
protein |
15888667
|
| C001277 | 5595 |
MAPK3
ERK-1 ERK1 ERT2 HS44KDAP HUMKER1A P44ERK1 P44MAPK PRKM3 p44-ERK1 p44-MAPK |
mitogen-activated protein kinase 3 (EC:2.7.11.24) | geldanamycin inhibits the reaction [Heptachlor results in increased phosphorylation of MAPK3 protein] |
decreases reaction
/ increases phosphorylation |
protein |
15888667
|
| C001277 | 5595 |
MAPK3
ERK-1 ERK1 ERT2 HS44KDAP HUMKER1A P44ERK1 P44MAPK PRKM3 p44-ERK1 p44-MAPK |
mitogen-activated protein kinase 3 (EC:2.7.11.24) | geldanamycin inhibits the reaction [Lindane results in increased phosphorylation of MAPK3 protein] |
decreases reaction
/ increases phosphorylation |
protein |
15888667
|
| C001277 | 5595 |
MAPK3
ERK-1 ERK1 ERT2 HS44KDAP HUMKER1A P44ERK1 P44MAPK PRKM3 p44-ERK1 p44-MAPK |
mitogen-activated protein kinase 3 (EC:2.7.11.24) | geldanamycin inhibits the reaction [Tretinoin results in increased phosphorylation of MAPK3 protein] |
decreases reaction
/ increases phosphorylation |
protein |
17293044
|
| C001277 | 5595 |
MAPK3
ERK-1 ERK1 ERT2 HS44KDAP HUMKER1A P44ERK1 P44MAPK PRKM3 p44-ERK1 p44-MAPK |
mitogen-activated protein kinase 3 (EC:2.7.11.24) | geldanamycin results in decreased phosphorylation of MAPK3 protein |
decreases phosphorylation
|
protein |
17293044
19167484 |
| C001277 | 4255 |
MGMT
|
O-6-methylguanine-DNA methyltransferase (EC:2.1.1.63) | geldanamycin results in increased expression of and results in increased activity of MGMT protein |
increases activity
/ increases expression |
protein |
16950796
|
| C001277 | 4312 |
MMP1
CLG CLGN |
matrix metallopeptidase 1 (interstitial collagenase) (EC:3.4.24.7) | [geldanamycin co-treated with PTHLH protein modified form] results in increased expression of MMP1 mRNA |
affects cotreatment
/ increases expression |
mRNA |
12724357
|
| C001277 | 1728 |
NQO1
DHQU DIA4 DTD NMOR1 NMORI QR1 |
NAD(P)H dehydrogenase, quinone 1 (EC:1.6.5.2) | NQO1 protein results in increased reduction of geldanamycin |
increases reduction
|
protein |
16825487
|
| C001277 | 142 |
PARP1
ADPRT ADPRT_1 ADPRT1 ARTD1 PARP PARP-1 PPOL pADPRT-1 |
poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) | geldanamycin inhibits the reaction [Doxorubicin results in increased cleavage of PARP1 protein] |
decreases reaction
/ increases cleavage |
protein |
16311509
|
| C001277 | 142 |
PARP1
ADPRT ADPRT_1 ADPRT1 ARTD1 PARP PARP-1 PPOL pADPRT-1 |
poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) | geldanamycin results in increased degradation of PARP1 protein |
increases degradation
|
protein |
17293044
|
| C001277 | 142 |
PARP1
ADPRT ADPRT_1 ADPRT1 ARTD1 PARP PARP-1 PPOL pADPRT-1 |
poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) | Tretinoin inhibits the reaction [geldanamycin results in increased degradation of PARP1 protein] |
decreases reaction
/ increases degradation |
protein |
17293044
|
| C001277 | 5241 |
PGR
NR3C3 PR |
progesterone receptor | geldanamycin results in decreased expression of PGR protein |
decreases expression
|
protein |
11448926
|
| C001277 | 5328 |
PLAU
ATF BDPLT5 QPD UPA URK u-PA |
plasminogen activator, urokinase (EC:3.4.21.73) | [geldanamycin co-treated with PTHLH protein modified form] results in decreased expression of PLAU mRNA |
affects cotreatment
/ decreases expression |
mRNA |
12724357
|
| C001277 | 5744 |
PTHLH
BDE2 HHM PLP PTHR PTHRP |
parathyroid hormone-like hormone | [geldanamycin co-treated with PTHLH protein modified form] results in decreased expression of PLAU mRNA |
affects cotreatment
/ decreases expression |
protein |
12724357
|
| C001277 | 5744 |
PTHLH
BDE2 HHM PLP PTHR PTHRP |
parathyroid hormone-like hormone | [geldanamycin co-treated with PTHLH protein modified form] results in increased expression of MMP1 mRNA |
affects cotreatment
/ increases expression |
protein |
12724357
|
| C001277 | 5747 |
PTK2
FADK FAK FAK1 FRNK PPP1R71 p125FAK pp125FAK |
protein tyrosine kinase 2 (EC:2.7.10.2) | geldanamycin results in decreased phosphorylation of PTK2 protein |
decreases phosphorylation
|
protein |
12811834
|
| C001277 | 5747 |
PTK2
FADK FAK FAK1 FRNK PPP1R71 p125FAK pp125FAK |
protein tyrosine kinase 2 (EC:2.7.10.2) | geldanamycin results in increased degradation of PTK2 protein |
increases degradation
|
protein |
9973544
|
| C001277 | 5894 |
RAF1
CRAF NS5 Raf-1 c-Raf |
v-raf-1 murine leukemia viral oncogene homolog 1 (EC:2.7.11.1) | geldanamycin results in decreased expression of and results in decreased phosphorylation of RAF1 protein |
decreases expression
/ decreases phosphorylation |
protein |
19167484
|
| C001277 | 6714 |
SRC
ASV SRC1 c-SRC p60-Src |
v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (EC:2.7.10.2) | geldanamycin inhibits the reaction [HSP90AA1 protein binds to SRC protein binds to CDC37 protein] |
affects binding
/ decreases reaction |
protein |
17223712
|
| C001277 | 6714 |
SRC
ASV SRC1 c-SRC p60-Src |
v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (EC:2.7.10.2) | geldanamycin inhibits the reaction [Tetrachlorodibenzodioxin affects the localization of SRC protein] |
affects localization
/ decreases reaction |
protein |
17223712
|
| C001277 | 10273 |
STUB1
CHIP HSPABP2 NY-CO-7 SDCCAG7 UBOX1 |
STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase | geldanamycin promotes the reaction [ESR1 protein binds to STUB1 protein] |
affects binding
/ increases reaction |
protein |
16037132
|
| C001277 | 10273 |
STUB1
CHIP HSPABP2 NY-CO-7 SDCCAG7 UBOX1 |
STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase | STUB1 protein promotes the reaction [geldanamycin results in increased degradation of ESR1 protein] |
increases degradation
/ increases reaction |
protein |
16037132
|
| C001277 | 7124 |
TNF
DIF TNF-alpha TNFA TNFSF2 |
tumor necrosis factor | geldanamycin inhibits the reaction [TNF protein results in increased expression of IL8 mRNA] |
decreases reaction
/ increases expression |
protein |
11472980
|
| C001277 | 7124 |
TNF
DIF TNF-alpha TNFA TNFSF2 |
tumor necrosis factor | geldanamycin inhibits the reaction [TNF protein results in increased expression of IL8 protein] |
decreases reaction
/ increases expression |
protein |
11472980
|
| C001277 | 7157 |
TP53
BCC7 LFS1 P53 TRP53 |
tumor protein p53 | geldanamycin affects the localization of TP53 protein |
affects localization
|
protein |
17293044
|
| C001277 | 7157 |
TP53
BCC7 LFS1 P53 TRP53 |
tumor protein p53 | Tretinoin inhibits the reaction [geldanamycin affects the localization of TP53 protein] |
affects localization
/ decreases reaction |
protein |
17293044
|
Related Disease
Diseases related to proteins in ChEMBL interactions
OMIM (8)
| OMIM | preferred title | UniProt |
|---|---|---|
| #114500 | Colorectal cancer; crc |
P84022
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #613795 | Loeys-dietz syndrome, type 3; lds3 |
P84022
|
| #613688 | Long qt syndrome 2; lqt2 |
Q12809
|
| #607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
| #609620 | Short qt syndrome 1; sqt1 |
Q12809
|
| #273300 | Testicular germ cell tumor; tgct |
O94804
|
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
KEGG DISEASE (7)
| KEGG | disease name | UniProt |
|---|---|---|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H00342 | Tuberculosis |
P11473
(related)
|
| H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
| H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00720 | Long QT syndrome |
Q12809
(related)
|
| H00725 | Short QT syndrome |
Q12809
(related)
|
Diseases related to CTD interactions
4 disease from interactions of metabolites
| MeSH disease | OMIM | compound | disease name | evidence type |
reference
pmid |
|---|---|---|---|---|---|
| D001284 | C001277 | Atrophy |
marker/mechanism
|
9664232
|
|
| D005909 | C001277 | Glioblastoma |
therapeutic
|
12811834
|
|
| D006529 | C001277 | Hepatomegaly |
marker/mechanism
|
9664232
|
|
| D009361 | C001277 | Neoplasm Invasiveness |
therapeutic
|
12811834
|