PCIDB

KNApSAcK Metabolite C00002057

Metabolite

KNApSAcK Entry

id C00002057
Name Nicotine
CAS RN 54-11-5
Standard InChI InChI=1S/C10H14N2/c1-12-7-3-5-10(12)9-4-2-6-11-8-9/h2,4,6,8,10H,3,5,7H2,1H3/t10-/m0/s1
Standard InChI (Main Layer) InChI=1S/C10H14N2/c1-12-7-3-5-10(12)9-4-2-6-11-8-9/h2,4,6,8,10H,3,5,7H2,1H3

Cluster

Phytochemical cluster No. 1
KCF-S cluster No. 2084

Link

ChEMBL

By standard InChI CHEMBL3
By standard InChI Main Layer CHEMBL3 CHEMBL9732 CHEMBL440464 CHEMBL1628647

KEGG

By LinkDB C00745

CTD

By CAS RN D009538

Human Protein / Gene in interaction

131 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 CHEMBL3 CHEMBL1909136 (2)
1 / 0
Q9Y6L6 Solute carrier organic anion transporter family member 1B1 Electrochemical transporter CHEMBL3 CHEMBL2169429 (1)
1 / 0
O15244 Solute carrier family 22 member 2 Drug uniporter CHEMBL3 CHEMBL2077774 (1) CHEMBL2077775 (1)
0 / 0
O94956 Solute carrier organic anion transporter family member 2B1 Unclassified protein CHEMBL3 CHEMBL2169431 (1)
0 / 0
P49798 Regulator of G-protein signaling 4 Unclassified protein CHEMBL3 CHEMBL1794499 (3)
2 / 0
P21728 D(1A) dopamine receptor Dopamine receptor CHEMBL3 CHEMBL1738091 (1) CHEMBL1909139 (2)
0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase CHEMBL3 CHEMBL1909131 (2)
0 / 3
Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH, Kv10-12.x (Ether-a-go-go) CHEMBL3 CHEMBL440464 CHEMBL766814 (1) CHEMBL829152 (1)
CHEMBL1036648 (1) CHEMBL1027667 (2)
CHEMBL954102 (1) CHEMBL1676103 (1)
CHEMBL1909190 (2)
2 / 2
P08246 Neutrophil elastase S1A CHEMBL3 CHEMBL1909195 (2)
2 / 1
P33765 Adenosine receptor A3 Adenosine receptor CHEMBL3 CHEMBL1909215 (2)
0 / 0
Q16539 Mitogen-activated protein kinase 14 p38 CHEMBL3 CHEMBL1909201 (2)
0 / 0
P49146 Neuropeptide Y receptor type 2 Neuropeptide Y receptor CHEMBL3 CHEMBL1909176 (2)
0 / 0
P29466 Caspase-1 C14 CHEMBL3 CHEMBL1909193 (2)
0 / 0
P17252 Protein kinase C alpha type Alpha CHEMBL3 CHEMBL1909198 (2)
0 / 0
P27361 Mitogen-activated protein kinase 3 Erk CHEMBL3 CHEMBL1909199 (2)
0 / 0
P14780 Matrix metalloproteinase-9 M10A CHEMBL3 CHEMBL1909197 (2)
2 / 2
O15245 Solute carrier family 22 member 1 Drug uniporter CHEMBL3 CHEMBL993349 (1) CHEMBL2076204 (1)
CHEMBL2077751 (1)
0 / 0
P02545 Prelamin-A/C Unclassified protein CHEMBL9732 CHEMBL1614544 (1)
11 / 10
P00918 Carbonic anhydrase 2 Lyase CHEMBL3 CHEMBL1909123 (2)
1 / 2
P07550 Beta-2 adrenergic receptor Adrenergic receptor CHEMBL3 CHEMBL1909092 (2)
0 / 1
P21397 Amine oxidase [flavin-containing] A Oxidoreductase CHEMBL3 CHEMBL1909169 (2)
1 / 1
P25021 Histamine H2 receptor Histamine receptor CHEMBL3 CHEMBL1909157 (2)
0 / 0
P35367 Histamine H1 receptor Histamine receptor CHEMBL3 CHEMBL1909156 (2)
0 / 0
Q01959 Sodium-dependent dopamine transporter Dopamine CHEMBL3 CHEMBL1909143 (2)
1 / 0
P08912 Muscarinic acetylcholine receptor M5 Acetylcholine receptor CHEMBL3 CHEMBL1909174 (2)
0 / 0
P18825 Alpha-2C adrenergic receptor Adrenergic receptor CHEMBL3 CHEMBL1909090 (2)
0 / 0
P13945 Beta-3 adrenergic receptor Adrenergic receptor CHEMBL3 CHEMBL1909093 (2)
0 / 0
P32297 Neuronal acetylcholine receptor subunit alpha-3 CHRN alpha CHEMBL3 CHEMBL752378 (1) CHEMBL752535 (1)
CHEMBL750052 (1) CHEMBL750054 (1)
CHEMBL842925 (1) CHEMBL840083 (1)
CHEMBL838764 (1) CHEMBL839749 (1)
CHEMBL839756 (1) CHEMBL826914 (2)
CHEMBL827770 (1) CHEMBL827782 (1)
CHEMBL885360 (1) CHEMBL914876 (1)
CHEMBL914877 (1) CHEMBL914879 (1)
CHEMBL899884 (2) CHEMBL899887 (1)
CHEMBL964081 (1) CHEMBL1211579 (1)
CHEMBL1211582 (1) CHEMBL2025970 (1)
CHEMBL2025971 (1) CHEMBL2168998 (1)
CHEMBL2168999 (1) CHEMBL2169001 (1)
CHEMBL2169197 (1) CHEMBL2169198 (1)
CHEMBL2169199 (1) CHEMBL2169200 (1)
CHEMBL2169201 (1) CHEMBL2184682 (1)
CHEMBL2185120 (1) CHEMBL2188158 (1)
CHEMBL2188159 (1) CHEMBL2188594 (1)
CHEMBL2188597 (1) CHEMBL2210091 (1)
CHEMBL2210092 (1) CHEMBL2343668 (1)
1 / 0
P25024 C-X-C chemokine receptor type 1 CXC chemokine receptor CHEMBL3 CHEMBL1909127 (2)
0 / 0
P06241 Tyrosine-protein kinase Fyn Src CHEMBL3 CHEMBL1909204 (2)
0 / 0
Q08209 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform Ser_Thr CHEMBL3 CHEMBL1909202 (2)
0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 CHEMBL3 CHEMBL1909135 (2)
0 / 1
P30926 Neuronal acetylcholine receptor subunit beta-4 CHRN beta CHEMBL3 CHEMBL752377 (1) CHEMBL750052 (1)
CHEMBL750054 (1) CHEMBL750434 (1)
CHEMBL842925 (1) CHEMBL838764 (1)
CHEMBL839749 (1) CHEMBL826909 (1)
CHEMBL826912 (1) CHEMBL826914 (2)
CHEMBL826916 (3) CHEMBL827770 (1)
CHEMBL827781 (1) CHEMBL885360 (1)
CHEMBL914876 (1) CHEMBL914877 (1)
CHEMBL914879 (1) CHEMBL899884 (2)
CHEMBL899887 (1) CHEMBL1211579 (1)
CHEMBL1211582 (1) CHEMBL2025970 (1)
CHEMBL2025971 (1) CHEMBL2168998 (1)
CHEMBL2168999 (1) CHEMBL2169001 (1)
CHEMBL2169197 (1) CHEMBL2169198 (1)
CHEMBL2169199 (1) CHEMBL2169200 (1)
CHEMBL2169201 (1) CHEMBL2184682 (1)
CHEMBL2185120 (1) CHEMBL2188158 (1)
CHEMBL2188159 (1) CHEMBL2188169 (1)
CHEMBL2188594 (1) CHEMBL2188599 (1)
CHEMBL2209190 (1) CHEMBL2210091 (1)
CHEMBL2210093 (1) CHEMBL2343668 (1)
0 / 0
Q07001 Acetylcholine receptor subunit delta CHRN delta CHEMBL3 CHEMBL749348 (1) CHEMBL872144 (1)
CHEMBL1211578 (1) CHEMBL2025968 (1)
CHEMBL2025969 (1) CHEMBL2169000 (1)
CHEMBL2188156 (1) CHEMBL2188157 (1)
3 / 2
P43681 Neuronal acetylcholine receptor subunit alpha-4 CHRN alpha CHEMBL3 CHEMBL750057 (1) CHEMBL754719 (1)
CHEMBL756125 (1) CHEMBL883546 (1)
CHEMBL751862 (1) CHEMBL751864 (1)
CHEMBL751866 (1) CHEMBL751867 (1)
CHEMBL750434 (1) CHEMBL823923 (1)
CHEMBL823924 (1) CHEMBL842926 (1)
CHEMBL841305 (1) CHEMBL841328 (1)
CHEMBL828762 (1) CHEMBL838862 (1)
CHEMBL826915 (1) CHEMBL826916 (3)
CHEMBL827784 (1) CHEMBL835515 (1)
CHEMBL876279 (1) CHEMBL827699 (1)
CHEMBL882470 (1) CHEMBL883060 (1)
CHEMBL885148 (1) CHEMBL914880 (1)
CHEMBL890277 (2) CHEMBL899886 (2)
CHEMBL899885 (1) CHEMBL901310 (1)
CHEMBL1028499 (1) CHEMBL964079 (1)
CHEMBL1211577 (1) CHEMBL1260650 (1)
CHEMBL1260658 (1) CHEMBL1260659 (1)
CHEMBL1260660 (1) CHEMBL1838046 (1)
CHEMBL1838047 (1) CHEMBL1838621 (1)
CHEMBL1838622 (1) CHEMBL1948416 (1)
CHEMBL2025963 (1) CHEMBL2025964 (1)
CHEMBL2025966 (1) CHEMBL2025967 (1)
CHEMBL2067156 (1) CHEMBL2184684 (1)
CHEMBL2185122 (1) CHEMBL2182411 (1)
CHEMBL2188160 (1) CHEMBL2188161 (2)
CHEMBL2188162 (1) CHEMBL2188163 (1)
CHEMBL2188164 (2) CHEMBL2188169 (1)
CHEMBL2188173 (1) CHEMBL2188599 (1)
CHEMBL2188602 (1) CHEMBL2209190 (1)
CHEMBL2210090 (1) CHEMBL2330760 (1)
CHEMBL2330761 (1) CHEMBL2330762 (1)
1 / 1
P07510 Acetylcholine receptor subunit gamma CHRN gamma CHEMBL3 CHEMBL749348 (1) CHEMBL872144 (1)
CHEMBL1211578 (1) CHEMBL2025968 (1)
CHEMBL2025969 (1) CHEMBL2169000 (1)
CHEMBL2188156 (1) CHEMBL2188157 (1)
2 / 1
P17787 Neuronal acetylcholine receptor subunit beta-2 CHRN beta CHEMBL3 CHEMBL752535 (1) CHEMBL750057 (1)
CHEMBL754719 (1) CHEMBL756125 (1)
CHEMBL883546 (1) CHEMBL751862 (1)
CHEMBL751864 (1) CHEMBL751866 (1)
CHEMBL751867 (1) CHEMBL823923 (1)
CHEMBL823924 (1) CHEMBL842925 (1)
CHEMBL842926 (1) CHEMBL841305 (1)
CHEMBL841328 (1) CHEMBL828762 (1)
CHEMBL840083 (1) CHEMBL838862 (1)
CHEMBL839756 (1) CHEMBL826915 (1)
CHEMBL827782 (1) CHEMBL827784 (1)
CHEMBL835515 (1) CHEMBL876279 (1)
CHEMBL827699 (1) CHEMBL882470 (1)
CHEMBL883060 (1) CHEMBL885148 (1)
CHEMBL914880 (1) CHEMBL890277 (2)
CHEMBL899886 (2) CHEMBL899885 (1)
CHEMBL901310 (1) CHEMBL1211577 (1)
CHEMBL1260650 (1) CHEMBL1260658 (1)
CHEMBL1260659 (1) CHEMBL1260660 (1)
CHEMBL1838046 (1) CHEMBL1838047 (1)
CHEMBL1838621 (1) CHEMBL1838622 (1)
CHEMBL1948416 (1) CHEMBL2025963 (1)
CHEMBL2025964 (1) CHEMBL2025966 (1)
CHEMBL2025967 (1) CHEMBL2025970 (1)
CHEMBL2025971 (1) CHEMBL2067156 (1)
CHEMBL2168999 (1) CHEMBL2169197 (1)
CHEMBL2169199 (1) CHEMBL2169201 (1)
CHEMBL2184684 (1) CHEMBL2185122 (1)
CHEMBL2182411 (1) CHEMBL2188160 (1)
CHEMBL2188161 (2) CHEMBL2188162 (1)
CHEMBL2188163 (1) CHEMBL2188164 (2)
CHEMBL2188173 (1) CHEMBL2188597 (1)
CHEMBL2188602 (1) CHEMBL2210090 (1)
CHEMBL2210092 (1) CHEMBL2210094 (1)
CHEMBL2330760 (1) CHEMBL2330761 (1)
CHEMBL2330762 (1)
1 / 1
P02708 Acetylcholine receptor subunit alpha CHRN alpha CHEMBL3 CHEMBL749348 (1) CHEMBL842920 (1)
CHEMBL842923 (1) CHEMBL872144 (1)
CHEMBL1211578 (1) CHEMBL2025968 (1)
CHEMBL2025969 (1) CHEMBL2169000 (1)
CHEMBL2188156 (1) CHEMBL2188157 (1)
3 / 2
P11230 Acetylcholine receptor subunit beta CHRN beta CHEMBL3 CHEMBL749348 (1) CHEMBL842925 (1)
CHEMBL872144 (1) CHEMBL1211578 (1)
CHEMBL2025968 (1) CHEMBL2025969 (1)
CHEMBL2169000 (1) CHEMBL2188156 (1)
CHEMBL2188157 (1)
2 / 1
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily CHEMBL3 CHEMBL1909203 (2)
1 / 11
P14416 D(2) dopamine receptor Dopamine receptor CHEMBL3 CHEMBL1909140 (2)
2 / 0
P23219 Prostaglandin G/H synthase 1 Oxidoreductase CHEMBL3 CHEMBL1909130 (2)
0 / 0
P37288 Vasopressin V1a receptor Vasopressin and oxytocin receptor CHEMBL3 CHEMBL1909120 (2)
0 / 0
P41145 Kappa-type opioid receptor Opioid receptor CHEMBL3 CHEMBL1909181 (2)
0 / 0
Q9Y271 Cysteinyl leukotriene receptor 1 Leukotriene receptor CHEMBL3 CHEMBL1909164 (2)
0 / 0
P29274 Adenosine receptor A2a Adenosine receptor CHEMBL3 CHEMBL1909214 (2)
0 / 0
P25929 Neuropeptide Y receptor type 1 Neuropeptide Y receptor CHEMBL3 CHEMBL1909175 (2)
0 / 0
P50052 Type-2 angiotensin II receptor Angiotensin receptor CHEMBL3 CHEMBL1909096 (2)
1 / 1
P17948 Vascular endothelial growth factor receptor 1 Vegfr CHEMBL3 CHEMBL1909118 (2)
0 / 0
P41968 Melanocortin receptor 3 Melanocortin receptor CHEMBL3 CHEMBL1909166 (2)
1 / 0
P00352 Retinal dehydrogenase 1 Enzyme CHEMBL3 CHEMBL9732 CHEMBL1614458 (4)
0 / 0
P11509 Cytochrome P450 2A6 Cytochrome P450 2A6 CHEMBL3 CHEMBL9732 CHEMBL839581 (1) CHEMBL832816 (1)
CHEMBL1023677 (1) CHEMBL1743266 (1)
CHEMBL1743365 (1) CHEMBL1909133 (2)
0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme CHEMBL9732 CHEMBL1738606 (1)
0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein CHEMBL3 CHEMBL440464 CHEMBL1794584 (2)
2 / 0
O75496 Geminin Unclassified protein CHEMBL3 CHEMBL440464 CHEMBL2114843 (1) CHEMBL2114780 (1)
0 / 0
P04035 3-hydroxy-3-methylglutaryl-coenzyme A reductase Oxidoreductase CHEMBL3 CHEMBL1909158 (2)
0 / 0
P08913 Alpha-2A adrenergic receptor Adrenergic receptor CHEMBL3 CHEMBL1909088 (2)
0 / 0
P21917 D(4) dopamine receptor Dopamine receptor CHEMBL3 CHEMBL1909142 (2)
0 / 0
P30988 Calcitonin receptor Calcitonin receptor CHEMBL3 CHEMBL1909101 (2)
0 / 0
P35462 D(3) dopamine receptor Dopamine receptor CHEMBL3 CHEMBL1909141 (2)
1 / 0
P41143 Delta-type opioid receptor Opioid receptor CHEMBL3 CHEMBL1909180 (2)
0 / 0
P46098 5-hydroxytryptamine receptor 3A NS CHEMBL3 CHEMBL618130 (1) CHEMBL896285 (1)
0 / 0
Q92731 Estrogen receptor beta NR3A2 CHEMBL3 CHEMBL1909146 (2)
0 / 1
P41595 5-hydroxytryptamine receptor 2B Serotonin receptor CHEMBL3 CHEMBL1909104 (2)
0 / 0
P25101 Endothelin-1 receptor Endothelin receptor CHEMBL3 CHEMBL1909144 (2)
0 / 0
P30411 B2 bradykinin receptor Bradykinin receptor CHEMBL3 CHEMBL1909100 (2)
0 / 0
P10145 Interleukin-8 Secreted protein CHEMBL3 CHEMBL2114835 (1)
0 / 0
P32245 Melanocortin receptor 4 Melanocortin receptor CHEMBL3 CHEMBL1909167 (2)
1 / 0
P32238 Cholecystokinin receptor type A Cholecystokinin receptor CHEMBL3 CHEMBL1909129 (2)
0 / 0
P08311 Cathepsin G S1A CHEMBL3 CHEMBL1909194 (2)
0 / 0
Q99720 Sigma non-opioid intracellular receptor 1 Membrane receptor CHEMBL3 CHEMBL846484 (1) CHEMBL1909110 (2)
1 / 0
P03956 Interstitial collagenase M10A CHEMBL3 CHEMBL1909196 (2)
0 / 1
P32241 Vasoactive intestinal polypeptide receptor 1 Vasoactive intestinal peptide receptor CHEMBL3 CHEMBL1909119 (2)
0 / 0
P83916 Chromobox protein homolog 1 Unclassified protein CHEMBL3 CHEMBL1738610 (1)
0 / 0
Q9NPD5 Solute carrier organic anion transporter family member 1B3 Electrochemical transporter CHEMBL3 CHEMBL2169430 (1)
1 / 0
P04150 Glucocorticoid receptor NR3C1 CHEMBL3 CHEMBL1909150 (2)
0 / 1
P08172 Muscarinic acetylcholine receptor M2 Acetylcholine receptor CHEMBL3 CHEMBL1909171 (2)
2 / 0
P11229 Muscarinic acetylcholine receptor M1 Acetylcholine receptor CHEMBL3 CHEMBL1909170 (2)
0 / 0
P21554 Cannabinoid receptor 1 Cannabinoid receptor CHEMBL3 CHEMBL1909122 (2)
0 / 0
P31645 Sodium-dependent serotonin transporter Serotonin CHEMBL3 CHEMBL1909109 (2)
2 / 0
P04626 Receptor tyrosine-protein kinase erbB-2 TK tyrosine-protein kinase EGFR subfamily CHEMBL3 CHEMBL1909205 (2)
5 / 10
P20309 Muscarinic acetylcholine receptor M3 Acetylcholine receptor CHEMBL3 CHEMBL1909172 (2)
1 / 0
P21452 Substance-K receptor Neurokinin receptor CHEMBL3 CHEMBL1909114 (2)
0 / 0
P51679 C-C chemokine receptor type 4 CC chemokine receptor CHEMBL3 CHEMBL1909125 (2)
0 / 0
P51681 C-C chemokine receptor type 5 CC chemokine receptor CHEMBL3 CHEMBL1909126 (2)
3 / 0
P50406 5-hydroxytryptamine receptor 6 Serotonin receptor CHEMBL3 CHEMBL1909108 (2)
0 / 0
P36544 Neuronal acetylcholine receptor subunit alpha-7 CHRN alpha CHEMBL3 CHEMBL750438 (1) CHEMBL750444 (1)
CHEMBL751838 (1) CHEMBL882443 (1)
CHEMBL830079 (1) CHEMBL839695 (1)
CHEMBL830082 (1) CHEMBL830005 (1)
CHEMBL885367 (1) CHEMBL896283 (2)
CHEMBL896284 (2) CHEMBL1034198 (1)
CHEMBL961846 (1) CHEMBL953564 (2)
CHEMBL1211581 (1) CHEMBL1261017 (1)
CHEMBL1832420 (1) CHEMBL1948415 (1)
CHEMBL2184685 (1) CHEMBL2182415 (1)
0 / 0
P41597 C-C chemokine receptor type 2 CC chemokine receptor CHEMBL3 CHEMBL1909124 (2)
1 / 0
P28482 Mitogen-activated protein kinase 1 Erk CHEMBL3 CHEMBL1909200 (2)
0 / 0
P08575 Receptor-type tyrosine-protein phosphatase C Enzyme CHEMBL3 CHEMBL1909207 (2)
2 / 1
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 CHEMBL3 CHEMBL830921 (1) CHEMBL1909132 (2)
0 / 0
Q92887 Canalicular multispecific organic anion transporter 1 Unclassified protein CHEMBL3 CHEMBL1006005 (1)
1 / 1
O75762 Transient receptor potential cation channel subfamily A member 1 Unclassified protein CHEMBL3 CHEMBL1118242 (1)
1 / 0
P51449 Nuclear receptor ROR-gamma Nuclear hormone receptor subfamily 1 group F member 3 CHEMBL3 CHEMBL2114842 (1)
0 / 0
O76074 cGMP-specific 3',5'-cyclic phosphodiesterase PDE_5A CHEMBL3 CHEMBL1909186 (2)
0 / 0
P03372 Estrogen receptor NR3A1 CHEMBL3 CHEMBL1909145 (2)
1 / 1
P08588 Beta-1 adrenergic receptor Adrenergic receptor CHEMBL3 CHEMBL1909091 (2)
1 / 0
P22303 Acetylcholinesterase Hydrolase CHEMBL3 CHEMBL1909212 (2)
1 / 0
P28223 5-hydroxytryptamine receptor 2A Serotonin receptor CHEMBL3 CHEMBL1909211 (2)
0 / 0
P28335 5-hydroxytryptamine receptor 2C Serotonin receptor CHEMBL3 CHEMBL1909105 (2)
0 / 0
P35372 Mu-type opioid receptor Opioid receptor CHEMBL3 CHEMBL1909182 (2)
0 / 0
P08173 Muscarinic acetylcholine receptor M4 Acetylcholine receptor CHEMBL3 CHEMBL1909173 (2)
0 / 0
P25103 Substance-P receptor Neurokinin receptor CHEMBL3 CHEMBL1909113 (2)
0 / 0
P25105 Platelet-activating factor receptor PAF receptor CHEMBL3 CHEMBL1909187 (2)
0 / 0
P33032 Melanocortin receptor 5 Melanocortin receptor CHEMBL3 CHEMBL1909168 (2)
0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 CHEMBL3 CHEMBL1909134 (2)
1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 CHEMBL3 CHEMBL1909138 (2)
0 / 1
P05181 Cytochrome P450 2E1 Cytochrome P450 2E1 CHEMBL3 CHEMBL1909137 (2)
0 / 0
P10636 Microtubule-associated protein tau Unclassified protein CHEMBL3 CHEMBL1614250 (1) CHEMBL1614421 (1)
4 / 3
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein CHEMBL3 CHEMBL2114890 (1)
0 / 0
P23975 Sodium-dependent noradrenaline transporter Norepinephrine CHEMBL3 CHEMBL1909094 (2)
1 / 1
P25100 Alpha-1D adrenergic receptor Adrenergic receptor CHEMBL3 CHEMBL1909087 (2)
0 / 0
P30542 Adenosine receptor A1 Adenosine receptor CHEMBL3 CHEMBL1909213 (2)
0 / 0
P18089 Alpha-2B adrenergic receptor Adrenergic receptor CHEMBL3 CHEMBL1909089 (2)
0 / 0
P24557 Thromboxane-A synthase Cytochrome P450 5A1 CHEMBL3 CHEMBL1909116 (2)
1 / 1
P06239 Tyrosine-protein kinase Lck Src CHEMBL3 CHEMBL1909206 (2)
0 / 1
P25025 C-X-C chemokine receptor type 2 CXC chemokine receptor CHEMBL3 CHEMBL1909128 (2)
0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme CHEMBL3 CHEMBL1738442 (1)
0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme CHEMBL9732 CHEMBL1614364 (1)
1 / 1
Q13951 Core-binding factor subunit beta Unclassified protein CHEMBL3 CHEMBL1613933 (1)
0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein CHEMBL3 CHEMBL1613933 (1)
1 / 6
Q15822 Neuronal acetylcholine receptor subunit alpha-2 CHRN alpha CHEMBL3 CHEMBL752377 (1) CHEMBL826909 (1)
CHEMBL826912 (1) CHEMBL827781 (1)
CHEMBL2210093 (1) CHEMBL2210094 (1)
1 / 1
Q9H015 Solute carrier family 22 member 4 Unclassified protein CHEMBL3 CHEMBL2076160 (1)
1 / 1
O76082 Solute carrier family 22 member 5 Unclassified protein CHEMBL3 CHEMBL2078075 (1) CHEMBL2078113 (1)
1 / 2
Q8WXA8 5-hydroxytryptamine receptor 3C NS CHEMBL3 CHEMBL618130 (1)
0 / 0
Q70Z44 5-hydroxytryptamine receptor 3D NS CHEMBL3 CHEMBL618130 (1)
0 / 0
O95264 5-hydroxytryptamine receptor 3B NS CHEMBL3 CHEMBL618130 (1)
0 / 0
A5X5Y0 5-hydroxytryptamine receptor 3E NS CHEMBL3 CHEMBL618130 (1)
0 / 0
Q05901 Neuronal acetylcholine receptor subunit beta-3 CHRN beta CHEMBL3 CHEMBL842925 (1)
0 / 0
P30532 Neuronal acetylcholine receptor subunit alpha-5 CHRN alpha CHEMBL3 CHEMBL2025970 (1) CHEMBL2025971 (1)
CHEMBL2168999 (1) CHEMBL2169197 (1)
CHEMBL2169199 (1) CHEMBL2169201 (1)
1 / 0
Q13148 TAR DNA-binding protein 43 Unclassified protein CHEMBL3 CHEMBL2354287 (1)
1 / 1

CTD interaction (891)

compound gene gene name gene description interaction interaction type form reference
pmid
D009538 9625 AATK
AATYK
AATYK1
LMR1
LMTK1
p35BP
apoptosis-associated tyrosine kinase (EC:2.7.11.1) Nicotine results in increased expression of AATK mRNA increases expression
mRNA 18247414
D009538 1636 ACE
ACE1
CD143
DCP
DCP1
ICH
MVCD3
angiotensin I converting enzyme (EC:3.4.15.1) Nicotine results in increased expression of ACE mRNA increases expression
mRNA 11166759
D009538 153 ADRB1
ADRB1R
B1AR
BETA1AR
RHR
adrenoceptor beta 1 [Atenolol binds to and results in decreased activity of ADRB1 protein] inhibits the reaction [Nicotine results in increased expression of PTGS2 protein] affects binding
/ decreases activity
/ decreases reaction
/ increases expression
protein 17003101
D009538 153 ADRB1
ADRB1R
B1AR
BETA1AR
RHR
adrenoceptor beta 1 [Atenolol binds to and results in decreased activity of ADRB1 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein] affects binding
/ decreases activity
/ decreases reaction
/ increases phosphorylation
protein 17003101
D009538 153 ADRB1
ADRB1R
B1AR
BETA1AR
RHR
adrenoceptor beta 1 [Atenolol binds to and results in decreased activity of ADRB1 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein] affects binding
/ decreases activity
/ decreases reaction
/ increases phosphorylation
protein 17003101
D009538 153 ADRB1
ADRB1R
B1AR
BETA1AR
RHR
adrenoceptor beta 1 [Atenolol binds to and results in decreased activity of ADRB1 protein] which results in decreased susceptibility to Nicotine affects binding
/ decreases activity
/ decreases response to substance
protein 17003101
17369603
D009538 153 ADRB1
ADRB1R
B1AR
BETA1AR
RHR
adrenoceptor beta 1 Nicotine results in increased expression of ADRB1 mRNA increases expression
mRNA 17369603
D009538 154 ADRB2
ADRB2R
ADRBR
B2AR
BAR
BETA2AR
adrenoceptor beta 2, surface [ICI 118551 binds to and results in decreased activity of ADRB2 protein] inhibits the reaction [Nicotine results in increased abundance of Dinoprostone] affects binding
/ decreases activity
/ decreases reaction
/ increases abundance
protein 17369603
D009538 154 ADRB2
ADRB2R
ADRBR
B2AR
BAR
BETA2AR
adrenoceptor beta 2, surface [ICI 118551 binds to and results in decreased activity of ADRB2 protein] inhibits the reaction [Nicotine results in increased expression of PTGS2] affects binding
/ decreases activity
/ decreases reaction
/ increases expression
protein 17369603
D009538 154 ADRB2
ADRB2R
ADRBR
B2AR
BAR
BETA2AR
adrenoceptor beta 2, surface [ICI 118551 binds to and results in decreased activity of ADRB2 protein] inhibits the reaction [Nicotine results in increased expression of PTGS2 protein] affects binding
/ decreases activity
/ decreases reaction
/ increases expression
protein 17003101
D009538 154 ADRB2
ADRB2R
ADRBR
B2AR
BAR
BETA2AR
adrenoceptor beta 2, surface [ICI 118551 binds to and results in decreased activity of ADRB2 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein] affects binding
/ decreases activity
/ decreases reaction
/ increases phosphorylation
protein 17003101
D009538 154 ADRB2
ADRB2R
ADRBR
B2AR
BAR
BETA2AR
adrenoceptor beta 2, surface [ICI 118551 binds to and results in decreased activity of ADRB2 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein] affects binding
/ decreases activity
/ decreases reaction
/ increases phosphorylation
protein 17003101
D009538 154 ADRB2
ADRB2R
ADRBR
B2AR
BAR
BETA2AR
adrenoceptor beta 2, surface [ICI 118551 binds to and results in decreased activity of ADRB2 protein] which results in decreased susceptibility to Nicotine affects binding
/ decreases activity
/ decreases response to substance
protein 17003101
17369603
D009538 154 ADRB2
ADRB2R
ADRBR
B2AR
BAR
BETA2AR
adrenoceptor beta 2, surface Nicotine results in increased expression of ADRB2 mRNA increases expression
mRNA 17369603
D009538 207 AKT1
AKT
CWS6
PKB
PKB-ALPHA
PRKBA
RAC
RAC-ALPHA
v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Nicotine results in increased phosphorylation of and results in increased activity of AKT1 protein] decreases reaction
/ increases activity
/ increases phosphorylation
protein 12511591
D009538 207 AKT1
AKT
CWS6
PKB
PKB-ALPHA
PRKBA
RAC
RAC-ALPHA
v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) Curcumin inhibits the reaction [Nicotine results in increased expression of AKT1 protein modified form] decreases reaction
/ increases expression
protein 20727180
D009538 207 AKT1
AKT
CWS6
PKB
PKB-ALPHA
PRKBA
RAC
RAC-ALPHA
v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) Dihydro-beta-Erythroidine inhibits the reaction [Nicotine results in increased phosphorylation of and results in increased activity of AKT1 protein] decreases reaction
/ increases activity
/ increases phosphorylation
protein 12511591
D009538 207 AKT1
AKT
CWS6
PKB
PKB-ALPHA
PRKBA
RAC
RAC-ALPHA
v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) Nicotine results in increased expression of AKT1 protein modified form increases expression
protein 20727180
D009538 207 AKT1
AKT
CWS6
PKB
PKB-ALPHA
PRKBA
RAC
RAC-ALPHA
v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) Nicotine results in increased phosphorylation of and results in increased activity of AKT1 protein increases activity
/ increases phosphorylation
protein 12511591
D009538 207 AKT1
AKT
CWS6
PKB
PKB-ALPHA
PRKBA
RAC
RAC-ALPHA
v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) [Nicotine results in increased phosphorylation of and results in increased activity of AKT1 protein] which results in increased phosphorylation of EIF4EBP1 protein increases activity
/ increases phosphorylation
protein 12511591
D009538 207 AKT1
AKT
CWS6
PKB
PKB-ALPHA
PRKBA
RAC
RAC-ALPHA
v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) [Nicotine results in increased phosphorylation of and results in increased activity of AKT1 protein] which results in increased phosphorylation of FOXO1 protein increases activity
/ increases phosphorylation
protein 12511591
D009538 207 AKT1
AKT
CWS6
PKB
PKB-ALPHA
PRKBA
RAC
RAC-ALPHA
v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) [Nicotine results in increased phosphorylation of and results in increased activity of AKT1 protein] which results in increased phosphorylation of GSK3A protein increases activity
/ increases phosphorylation
protein 12511591
D009538 207 AKT1
AKT
CWS6
PKB
PKB-ALPHA
PRKBA
RAC
RAC-ALPHA
v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) [Nicotine results in increased phosphorylation of and results in increased activity of AKT1 protein] which results in increased phosphorylation of GSK3B protein increases activity
/ increases phosphorylation
protein 12511591
D009538 210 ALAD
ALADH
PBGS
aminolevulinate dehydratase (EC:4.2.1.24) Nicotine results in decreased activity of ALAD protein decreases activity
protein 8687997
D009538 216 ALDH1A1
ALDC
ALDH-E1
ALDH1
ALDH11
PUMB1
RALDH1
aldehyde dehydrogenase 1 family, member A1 (EC:1.2.1.36) Nicotine results in increased activity of ALDH1A1 protein increases activity
protein 23219715
D009538 240 ALOX5
5-LO
5-LOX
5LPG
LOG5
arachidonate 5-lipoxygenase (EC:1.13.11.34) AG 1879 inhibits the reaction [Nicotine results in increased expression of ALOX5 protein] decreases reaction
/ increases expression
protein 14569062
D009538 240 ALOX5
5-LO
5-LOX
5LPG
LOG5
arachidonate 5-lipoxygenase (EC:1.13.11.34) L 663536 inhibits the reaction [Nicotine results in increased expression of ALOX5 protein] decreases reaction
/ increases expression
protein 20061081
D009538 240 ALOX5
5-LO
5-LOX
5LPG
LOG5
arachidonate 5-lipoxygenase (EC:1.13.11.34) Nicotine results in increased expression of ALOX5 mRNA increases expression
mRNA 20061081
D009538 240 ALOX5
5-LO
5-LOX
5LPG
LOG5
arachidonate 5-lipoxygenase (EC:1.13.11.34) Nicotine results in increased expression of ALOX5 protein increases expression
protein 14569062
20061081
D009538 240 ALOX5
5-LO
5-LOX
5LPG
LOG5
arachidonate 5-lipoxygenase (EC:1.13.11.34) [tyrphostin AG 1478 co-treated with AG 1879] inhibits the reaction [Nicotine results in increased expression of ALOX5 protein] affects cotreatment
/ decreases reaction
/ increases expression
protein 14569062
D009538 240 ALOX5
5-LO
5-LOX
5LPG
LOG5
arachidonate 5-lipoxygenase (EC:1.13.11.34) tyrphostin AG 1478 inhibits the reaction [Nicotine results in increased expression of ALOX5 protein] decreases reaction
/ increases expression
protein 14569062
D009538 240 ALOX5
5-LO
5-LOX
5LPG
LOG5
arachidonate 5-lipoxygenase (EC:1.13.11.34) U 0126 inhibits the reaction [Nicotine results in increased expression of ALOX5 mRNA] decreases reaction
/ increases expression
mRNA 20061081
D009538 262 AMD1
ADOMETDC
AMD
SAMDC
adenosylmethionine decarboxylase 1 (EC:4.1.1.50) Nicotine results in increased expression of AMD1 mRNA increases expression
mRNA 16949557
D009538 269 AMHR2
AMHR
MISR2
MISRII
MRII
anti-Mullerian hormone receptor, type II (EC:2.7.11.30) Nicotine results in decreased expression of AMHR2 mRNA decreases expression
mRNA 18247414
D009538 327 APEH
AARE
ACPH
APH
D3F15S2
D3S48E
DNF15S2
OPH
acylaminoacyl-peptide hydrolase (EC:3.4.19.1) Nicotine results in decreased expression of APEH mRNA decreases expression
mRNA 16949557
D009538 351 APP
AAA
ABETA
ABPP
AD1
APPI
CTFgamma
CVAP
PN-II
PN2
amyloid beta (A4) precursor protein Bungarotoxins inhibits the reaction [Nicotine inhibits the reaction [Copper results in increased expression of APP protein]] decreases reaction
/ increases expression
protein 16627626
D009538 351 APP
AAA
ABETA
ABPP
AD1
APPI
CTFgamma
CVAP
PN-II
PN2
amyloid beta (A4) precursor protein Mecamylamine inhibits the reaction [Nicotine inhibits the reaction [Copper results in increased expression of APP protein]] decreases reaction
/ increases expression
protein 16627626
D009538 351 APP
AAA
ABETA
ABPP
AD1
APPI
CTFgamma
CVAP
PN-II
PN2
amyloid beta (A4) precursor protein Nicotine inhibits the reaction [Copper promotes the reaction [APP protein binds to APP protein]] affects binding
/ decreases reaction
/ increases reaction
protein 16627626
D009538 351 APP
AAA
ABETA
ABPP
AD1
APPI
CTFgamma
CVAP
PN-II
PN2
amyloid beta (A4) precursor protein Nicotine inhibits the reaction [Copper results in increased expression of APP mRNA] decreases reaction
/ increases expression
mRNA 16627626
D009538 351 APP
AAA
ABETA
ABPP
AD1
APPI
CTFgamma
CVAP
PN-II
PN2
amyloid beta (A4) precursor protein Nicotine inhibits the reaction [Copper results in increased expression of APP protein] decreases reaction
/ increases expression
protein 16627626
D009538 351 APP
AAA
ABETA
ABPP
AD1
APPI
CTFgamma
CVAP
PN-II
PN2
amyloid beta (A4) precursor protein Nicotine results in decreased expression of APP mRNA decreases expression
mRNA 16627626
D009538 351 APP
AAA
ABETA
ABPP
AD1
APPI
CTFgamma
CVAP
PN-II
PN2
amyloid beta (A4) precursor protein Nicotine results in decreased expression of APP protein decreases expression
protein 16627626
D009538 55082 ARGLU1
arginine and glutamate rich 1 Nicotine results in increased expression of ARGLU1 mRNA increases expression
mRNA 16949557
D009538 8874 ARHGEF7
BETA-PIX
COOL-1
COOL1
Nbla10314
P50
P50BP
P85
P85COOL1
P85SPR
PAK3
PIXB
Rho guanine nucleotide exchange factor (GEF) 7 Nicotine results in decreased expression of ARHGEF7 mRNA decreases expression
mRNA 12588870
D009538 408 ARRB1
ARB1
ARR1
arrestin, beta 1 ARRB1 protein affects the reaction [Nicotine promotes the reaction [RB1 protein binds to RAF1 protein]] affects binding
/ affects reaction
/ increases reaction
protein 16862215
D009538 408 ARRB1
ARB1
ARR1
arrestin, beta 1 ARRB1 protein affects the reaction [Nicotine results in increased phosphorylation of and results in increased activity of SRC protein] affects reaction
/ increases activity
/ increases phosphorylation
protein 16862215
D009538 546 ATRX
ATR2
JMS
MRXHF1
RAD54
RAD54L
SFM1
SHS
XH2
XNP
ZNF-HX
alpha thalassemia/mental retardation syndrome X-linked (EC:3.6.4.12) Nicotine results in increased expression of ATRX mRNA increases expression
mRNA 16949557
D009538 572 BAD
BBC2
BCL2L8
BCL2-associated agonist of cell death Nicotine results in decreased expression of BAD mRNA decreases expression
mRNA 18247414
D009538 581 BAX
BCL2L4
BCL2-associated X protein L 663536 inhibits the reaction [Nicotine results in decreased expression of BAX protein] decreases expression
/ decreases reaction
protein 20061081
D009538 581 BAX
BCL2L4
BCL2-associated X protein Nicotine inhibits the reaction [[Cisplatin co-treated with Etoposide] affects the localization of BAX protein] affects cotreatment
/ affects localization
/ decreases reaction
protein 18676776
D009538 581 BAX
BCL2L4
BCL2-associated X protein Nicotine results in decreased expression of BAX protein decreases expression
protein 20061081
20106947
D009538 581 BAX
BCL2L4
BCL2-associated X protein Nicotine results in increased phosphorylation of BAX protein increases phosphorylation
protein 17525161
D009538 581 BAX
BCL2L4
BCL2-associated X protein PRKCZ protein affects the reaction [Nicotine results in increased phosphorylation of BAX protein] affects reaction
/ increases phosphorylation
protein 17525161
D009538 596 BCL2
Bcl-2
PPP1R50
B-cell CLL/lymphoma 2 Curcumin inhibits the reaction [Nicotine results in increased expression of BCL2 protein] decreases reaction
/ increases expression
protein 20727180
D009538 596 BCL2
Bcl-2
PPP1R50
B-cell CLL/lymphoma 2 edelfosine inhibits the reaction [Nicotine results in increased phosphorylation of BCL2 protein] decreases reaction
/ increases phosphorylation
protein 12421819
D009538 596 BCL2
Bcl-2
PPP1R50
B-cell CLL/lymphoma 2 L 663536 inhibits the reaction [Nicotine results in increased expression of BCL2 protein] decreases reaction
/ increases expression
protein 20061081
D009538 596 BCL2
Bcl-2
PPP1R50
B-cell CLL/lymphoma 2 Nicotine inhibits the reaction [Aflatoxin B1 results in decreased expression of BCL2 protein] decreases expression
/ decreases reaction
protein 22743290
D009538 596 BCL2
Bcl-2
PPP1R50
B-cell CLL/lymphoma 2 Nicotine results in increased expression of BCL2 protein increases expression
protein 18448488
20061081
20727180
D009538 596 BCL2
Bcl-2
PPP1R50
B-cell CLL/lymphoma 2 Nicotine results in increased expression of BCL2 protein modified form increases expression
protein 18676776
D009538 596 BCL2
Bcl-2
PPP1R50
B-cell CLL/lymphoma 2 Nicotine results in increased phosphorylation of BCL2 protein increases phosphorylation
protein 12421819
D009538 597 BCL2A1
ACC-1
ACC-2
BCL2L5
BFL1
GRS
HBPA1
BCL2-related protein A1 Nicotine results in decreased expression of BCL2A1 mRNA decreases expression
mRNA 18247414
D009538 627 BDNF
ANON2
BULN2
brain-derived neurotrophic factor BDNF gene polymorphism affects the susceptibility to Nicotine affects response to substance
gene 17186223
D009538 627 BDNF
ANON2
BULN2
brain-derived neurotrophic factor methyllycaconitine inhibits the reaction [Nicotine results in increased secretion of BDNF protein] decreases reaction
/ increases secretion
protein 16790237
D009538 627 BDNF
ANON2
BULN2
brain-derived neurotrophic factor Nicotine results in increased secretion of BDNF protein increases secretion
protein 16790237
D009538 632 BGLAP
BGP
OC
OCN
bone gamma-carboxyglutamate (gla) protein Nicotine results in decreased expression of BGLAP decreases expression
19436947
D009538 632 BGLAP
BGP
OC
OCN
bone gamma-carboxyglutamate (gla) protein Nicotine results in increased expression of BGLAP increases expression
19436947
D009538 632 BGLAP
BGP
OC
OCN
bone gamma-carboxyglutamate (gla) protein Tubocurarine inhibits the reaction [Nicotine results in increased expression of BGLAP] decreases reaction
/ increases expression
19436947
D009538 329 BIRC2
API1
HIAP2
Hiap-2
MIHB
RNF48
c-IAP1
cIAP1
baculoviral IAP repeat containing 2 Curcumin inhibits the reaction [Nicotine results in increased expression of BIRC2 protein] decreases reaction
/ increases expression
protein 20727180
D009538 329 BIRC2
API1
HIAP2
Hiap-2
MIHB
RNF48
c-IAP1
cIAP1
baculoviral IAP repeat containing 2 Nicotine results in increased expression of BIRC2 protein increases expression
protein 20727180
D009538 332 BIRC5
API4
EPR-1
baculoviral IAP repeat containing 5 Curcumin inhibits the reaction [Nicotine results in increased expression of BIRC5 protein] decreases reaction
/ increases expression
protein 20727180
D009538 332 BIRC5
API4
EPR-1
baculoviral IAP repeat containing 5 Hexamethonium affects the reaction [Nicotine results in increased expression of BIRC5 protein] affects reaction
/ increases expression
protein 16601104
D009538 332 BIRC5
API4
EPR-1
baculoviral IAP repeat containing 5 Nicotine inhibits the reaction [RB1 protein binds to BIRC5 promoter] affects binding
/ decreases reaction
promoter 16601104
D009538 332 BIRC5
API4
EPR-1
baculoviral IAP repeat containing 5 Nicotine promotes the reaction [E2F1 protein binds to BIRC5 promoter] affects binding
/ increases reaction
promoter 16601104
D009538 332 BIRC5
API4
EPR-1
baculoviral IAP repeat containing 5 Nicotine results in increased expression of BIRC5 mRNA increases expression
mRNA 16601104
19896492
21267677
D009538 332 BIRC5
API4
EPR-1
baculoviral IAP repeat containing 5 Nicotine results in increased expression of BIRC5 protein increases expression
protein 16601104
20727180
21267677
D009538 648 BMI1
FLVI2/BMI1
PCGF4
RNF51
BMI1 polycomb ring finger oncogene Nicotine results in increased expression of BMI1 mRNA increases expression
mRNA 23219715
D009538 648 BMI1
FLVI2/BMI1
PCGF4
RNF51
BMI1 polycomb ring finger oncogene Nicotine results in increased expression of BMI1 protein increases expression
protein 23219715
D009538 648 BMI1
FLVI2/BMI1
PCGF4
RNF51
BMI1 polycomb ring finger oncogene SNAI1 mutant form inhibits the reaction [Nicotine results in increased expression of BMI1 mRNA] decreases reaction
/ increases expression
mRNA 23219715
D009538 672 BRCA1
BRCAI
BRCC1
BROVCA1
IRIS
PNCA4
PPP1R53
PSCP
RNF53
breast cancer 1, early onset Nicotine results in decreased expression of BRCA1 mRNA decreases expression
mRNA 18247414
D009538 689 BTF3
BETA-NAC
BTF3a
BTF3b
NACB
basic transcription factor 3 Nicotine results in decreased expression of BTF3 mRNA decreases expression
mRNA 18247414
D009538 695 BTK
AGMX1
AT
ATK
BPK
IMD1
PSCTK1
XLA
Bruton agammaglobulinemia tyrosine kinase (EC:2.7.10.2) Nicotine results in decreased expression of BTK mRNA decreases expression
mRNA 18247414
D009538 728 C5AR1
C5A
C5AR
C5R1
CD88
complement component 5a receptor 1 Nicotine results in decreased expression of C5AR1 mRNA decreases expression
mRNA 18247414
D009538 730 C7
complement component 7 alpha-cobratoxin inhibits the reaction [Nicotine results in increased expression of C7 mRNA] decreases reaction
/ increases expression
mRNA 16949557
D009538 730 C7
complement component 7 Mecamylamine inhibits the reaction [Nicotine results in increased expression of C7 mRNA] decreases reaction
/ increases expression
mRNA 16949557
D009538 730 C7
complement component 7 Nicotine results in increased expression of C7 mRNA increases expression
mRNA 16949557
D009538 730 C7
complement component 7 Tubocurarine inhibits the reaction [Nicotine results in increased expression of C7 mRNA] decreases reaction
/ increases expression
mRNA 16949557
D009538 811 CALR
CRT
RO
SSA
cC1qR
calreticulin Nicotine results in increased expression of CALR mRNA increases expression
mRNA 16949557
D009538 830 CAPZA2
CAPPA2
CAPZ
capping protein (actin filament) muscle Z-line, alpha 2 Nicotine results in increased expression of CAPZA2 mRNA increases expression
mRNA 16949557
D009538 9607 CARTPT
CART
CART prepropeptide Nicotine results in decreased expression of CARTPT mRNA decreases expression
mRNA 18247414
D009538 834 CASP1
ICE
IL1BC
P45
caspase 1, apoptosis-related cysteine peptidase (EC:3.4.22.36) Nicotine affects the reaction [Staurosporine affects the localization of CASP1 protein] affects localization
/ affects reaction
protein 16927020
D009538 834 CASP1
ICE
IL1BC
P45
caspase 1, apoptosis-related cysteine peptidase (EC:3.4.22.36) Nicotine inhibits the reaction [Staurosporine results in increased activity of CASP1 protein] decreases reaction
/ increases activity
protein 16927020
D009538 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) geldanamycin inhibits the reaction [Nicotine results in increased activity of CASP3 protein] decreases reaction
/ increases activity
protein 12115584
D009538 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) L 663536 inhibits the reaction [Nicotine results in decreased expression of CASP3 protein] decreases expression
/ decreases reaction
protein 20061081
D009538 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) Nicotine inhibits the reaction [Aflatoxin B1 results in increased cleavage of CASP3 protein] decreases reaction
/ increases cleavage
protein 22743290
D009538 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) Nicotine inhibits the reaction [Cisplatin results in increased activity of CASP3 protein] decreases reaction
/ increases activity
protein 20106947
D009538 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) Nicotine inhibits the reaction [Paclitaxel results in increased activity of CASP3 protein] decreases reaction
/ increases activity
protein 20106947
D009538 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) Nicotine results in decreased activity of CASP3 protein decreases activity
protein 11701223
D009538 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) Nicotine results in decreased expression of CASP3 protein decreases expression
protein 20061081
D009538 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) Nicotine results in increased activity of CASP3 protein increases activity
protein 12115584
D009538 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) Nicotine results in increased expression of CASP3 increases expression
20383341
D009538 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) Nicotine results in increased expression of CASP3 mRNA increases expression
mRNA 16949557
D009538 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) Nicotine results in increased expression of CASP3 protein increases expression
protein 20457658
D009538 842 CASP9
APAF-3
APAF3
ICE-LAP6
MCH6
PPP1R56
caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) Nicotine inhibits the reaction [[Cisplatin co-treated with Etoposide] results in increased activity of CASP9 protein] affects cotreatment
/ decreases reaction
/ increases activity
protein 18676776
D009538 842 CASP9
APAF-3
APAF3
ICE-LAP6
MCH6
PPP1R56
caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) Nicotine results in decreased expression of CASP9 mRNA decreases expression
mRNA 16949557
D009538 867 CBL
C-CBL
CBL2
FRA11B
NSLL
RNF55
Cbl proto-oncogene, E3 ubiquitin protein ligase Nicotine results in increased expression of CBL mRNA increases expression
mRNA 18247414
D009538 11335 CBX3
HECH
HP1-GAMMA
HP1Hs-gamma
chromobox homolog 3 Nicotine results in increased expression of CBX3 mRNA increases expression
mRNA 16949557
D009538 6360 CCL16
CKb12
HCC-4
ILINCK
LCC-1
LEC
LMC
Mtn-1
NCC-4
NCC4
SCYA16
SCYL4
chemokine (C-C motif) ligand 16 Nicotine results in decreased expression of CCL16 mRNA decreases expression
mRNA 18247414
D009538 6352 CCL5
D17S136E
RANTES
SCYA5
SIS-delta
SISd
TCP228
eoCP
chemokine (C-C motif) ligand 5 Nicotine results in increased expression of CCL5 mRNA increases expression
mRNA 18247414
D009538 890 CCNA2
CCN1
CCNA
cyclin A2 Nicotine results in increased expression of CCNA2 protein increases expression
protein 18448488
20106947
D009538 891 CCNB1
CCNB
cyclin B1 Nicotine results in increased expression of CCNB1 protein increases expression
protein 20106947
D009538 595 CCND1
BCL1
D11S287E
PRAD1
U21B31
cyclin D1 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Nicotine results in increased expression of CCND1 protein] decreases reaction
/ increases expression
protein 18448488
D009538 595 CCND1
BCL1
D11S287E
PRAD1
U21B31
cyclin D1 alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [Nicotine results in increased expression of CCND1 protein] decreases reaction
/ increases expression
protein 20106947
D009538 595 CCND1
BCL1
D11S287E
PRAD1
U21B31
cyclin D1 Curcumin inhibits the reaction [Nicotine results in increased expression of CCND1 protein] decreases reaction
/ increases expression
protein 20727180
D009538 595 CCND1
BCL1
D11S287E
PRAD1
U21B31
cyclin D1 L 663536 inhibits the reaction [Nicotine results in increased expression of CCND1 mRNA] decreases reaction
/ increases expression
mRNA 20061081
D009538 595 CCND1
BCL1
D11S287E
PRAD1
U21B31
cyclin D1 L 663536 inhibits the reaction [Nicotine results in increased expression of CCND1 protein] decreases reaction
/ increases expression
protein 20061081
D009538 595 CCND1
BCL1
D11S287E
PRAD1
U21B31
cyclin D1 Nicotine promotes the reaction [CDK4 protein binds to CCND1 protein] affects binding
/ increases reaction
protein 18805435
D009538 595 CCND1
BCL1
D11S287E
PRAD1
U21B31
cyclin D1 Nicotine promotes the reaction [CDK6 protein binds to CCND1 protein] affects binding
/ increases reaction
protein 18805435
D009538 595 CCND1
BCL1
D11S287E
PRAD1
U21B31
cyclin D1 Nicotine results in increased expression of CCND1 mRNA increases expression
mRNA 18805435
20061081
D009538 595 CCND1
BCL1
D11S287E
PRAD1
U21B31
cyclin D1 Nicotine results in increased expression of CCND1 protein increases expression
protein 18448488
18805435
20061081
20106947
20727180
D009538 595 CCND1
BCL1
D11S287E
PRAD1
U21B31
cyclin D1 U 0126 inhibits the reaction [Nicotine results in increased expression of CCND1 protein] decreases reaction
/ increases expression
protein 18448488
D009538 894 CCND2
KIAK0002
cyclin D2 Nicotine results in decreased expression of CCND2 protein decreases expression
protein 15231866
D009538 898 CCNE1
CCNE
cyclin E1 L 663536 inhibits the reaction [Nicotine results in increased expression of CCNE1 protein] decreases reaction
/ increases expression
protein 20061081
D009538 898 CCNE1
CCNE
cyclin E1 Nicotine results in increased expression of CCNE1 protein increases expression
protein 20061081
D009538 901 CCNG2
cyclin G2 Nicotine results in increased expression of CCNG2 mRNA increases expression
mRNA 23416264
D009538 1234 CCR5
CC-CKR-5
CCCKR5
CCR-5
CD195
CKR-5
CKR5
CMKBR5
IDDM22
chemokine (C-C motif) receptor 5 (gene/pseudogene) Nicotine results in increased expression of CCR5 mRNA increases expression
mRNA 18247414
D009538 1235 CCR6
BN-1
C-C_CKR-6
CC-CKR-6
CCR-6
CD196
CKR-L3
CKRL3
CMKBR6
DCR2
DRY6
GPR29
GPRCY4
STRL22
chemokine (C-C motif) receptor 6 Nicotine results in decreased expression of CCR6 mRNA decreases expression
mRNA 18247414
D009538 9973 CCS
copper chaperone for superoxide dismutase Nicotine results in increased expression of CCS protein increases expression
protein 16627626
D009538 920 CD4
CD4mut
CD4 molecule Nicotine results in decreased expression of CD4 mRNA decreases expression
mRNA 18247414
D009538 4179 CD46
AHUS2
MCP
MIC10
TLX
TRA2.10
CD46 molecule, complement regulatory protein Nicotine results in increased expression of CD46 mRNA increases expression
mRNA 16949557
D009538 966 CD59
16.3A5
1F5
EJ16
EJ30
EL32
G344
HRF-20
HRF20
MAC-IP
MACIF
MEM43
MIC11
MIN1
MIN2
MIN3
MIRL
MSK21
p18-20
CD59 molecule, complement regulatory protein Nicotine results in increased expression of CD59 mRNA increases expression
mRNA 18247414
D009538 993 CDC25A
CDC25A2
cell division cycle 25A (EC:3.1.3.48) Nicotine inhibits the reaction [E2F4 protein binds to CDC25A promoter] affects binding
/ decreases reaction
promoter 16862215
D009538 993 CDC25A
CDC25A2
cell division cycle 25A (EC:3.1.3.48) Nicotine inhibits the reaction [E2F5 protein binds to CDC25A promoter] affects binding
/ decreases reaction
promoter 16862215
D009538 993 CDC25A
CDC25A2
cell division cycle 25A (EC:3.1.3.48) Nicotine inhibits the reaction [RB1 protein binds to CDC25A promoter] affects binding
/ decreases reaction
promoter 16862215
D009538 993 CDC25A
CDC25A2
cell division cycle 25A (EC:3.1.3.48) Nicotine inhibits the reaction [RBL1 protein binds to CDC25A promoter] affects binding
/ decreases reaction
promoter 16862215
D009538 993 CDC25A
CDC25A2
cell division cycle 25A (EC:3.1.3.48) Nicotine inhibits the reaction [RBL2 protein binds to CDC25A promoter] affects binding
/ decreases reaction
promoter 16862215
D009538 993 CDC25A
CDC25A2
cell division cycle 25A (EC:3.1.3.48) Nicotine promotes the reaction [E2F1 protein binds to CDC25A promoter] affects binding
/ increases reaction
promoter 16862215
D009538 993 CDC25A
CDC25A2
cell division cycle 25A (EC:3.1.3.48) Nicotine promotes the reaction [E2F2 protein binds to CDC25A promoter] affects binding
/ increases reaction
promoter 16862215
D009538 993 CDC25A
CDC25A2
cell division cycle 25A (EC:3.1.3.48) Nicotine promotes the reaction [E2F3 protein binds to CDC25A promoter] affects binding
/ increases reaction
promoter 16862215
D009538 990 CDC6
CDC18L
HsCDC18
HsCDC6
cell division cycle 6 Nicotine inhibits the reaction [E2F4 protein binds to CDC6 promoter] affects binding
/ decreases reaction
promoter 16862215
D009538 990 CDC6
CDC18L
HsCDC18
HsCDC6
cell division cycle 6 Nicotine inhibits the reaction [E2F5 protein binds to CDC6 promoter] affects binding
/ decreases reaction
promoter 16862215
D009538 990 CDC6
CDC18L
HsCDC18
HsCDC6
cell division cycle 6 Nicotine inhibits the reaction [RB1 protein binds to CDC6 promoter] affects binding
/ decreases reaction
promoter 16862215
D009538 990 CDC6
CDC18L
HsCDC18
HsCDC6
cell division cycle 6 Nicotine inhibits the reaction [RBL1 protein binds to CDC6 promoter] affects binding
/ decreases reaction
promoter 16862215
D009538 990 CDC6
CDC18L
HsCDC18
HsCDC6
cell division cycle 6 Nicotine inhibits the reaction [RBL2 protein binds to CDC6 promoter] affects binding
/ decreases reaction
promoter 16862215
D009538 990 CDC6
CDC18L
HsCDC18
HsCDC6
cell division cycle 6 Nicotine promotes the reaction [E2F1 protein binds to CDC6 promoter] affects binding
/ increases reaction
promoter 16862215
D009538 990 CDC6
CDC18L
HsCDC18
HsCDC6
cell division cycle 6 Nicotine promotes the reaction [E2F2 protein binds to CDC6 promoter] affects binding
/ increases reaction
promoter 16862215
D009538 990 CDC6
CDC18L
HsCDC18
HsCDC6
cell division cycle 6 Nicotine promotes the reaction [E2F3 protein binds to CDC6 promoter] affects binding
/ increases reaction
promoter 16862215
D009538 999 CDH1
Arc-1
CD324
CDHE
ECAD
LCAM
UVO
cadherin 1, type 1, E-cadherin (epithelial) L 663536 inhibits the reaction [Nicotine results in decreased expression of CDH1 mRNA] decreases expression
/ decreases reaction
mRNA 20061081
D009538 999 CDH1
Arc-1
CD324
CDHE
ECAD
LCAM
UVO
cadherin 1, type 1, E-cadherin (epithelial) Nicotine results in decreased expression of CDH1 mRNA decreases expression
mRNA 20061081
23219715
D009538 999 CDH1
Arc-1
CD324
CDHE
ECAD
LCAM
UVO
cadherin 1, type 1, E-cadherin (epithelial) Nicotine results in decreased expression of CDH1 protein decreases expression
protein 18844224
D009538 999 CDH1
Arc-1
CD324
CDHE
ECAD
LCAM
UVO
cadherin 1, type 1, E-cadherin (epithelial) U 0126 inhibits the reaction [Nicotine results in decreased expression of CDH1 mRNA] decreases expression
/ decreases reaction
mRNA 20061081
D009538 8621 CDK13
CDC2L
CDC2L5
CHED
hCDK13
cyclin-dependent kinase 13 (EC:2.7.11.23 2.7.11.22) Nicotine results in increased expression of CDK13 mRNA increases expression
mRNA 16949557
D009538 1019 CDK4
CMM3
PSK-J3
cyclin-dependent kinase 4 (EC:2.7.11.22) Bungarotoxins inhibits the reaction [Nicotine results in decreased expression of CDK4 protein] decreases expression
/ decreases reaction
protein 15231866
D009538 1019 CDK4
CMM3
PSK-J3
cyclin-dependent kinase 4 (EC:2.7.11.22) Dihydro-beta-Erythroidine inhibits the reaction [Nicotine results in decreased expression of CDK4 protein] decreases expression
/ decreases reaction
protein 15231866
D009538 1019 CDK4
CMM3
PSK-J3
cyclin-dependent kinase 4 (EC:2.7.11.22) Hexamethonium inhibits the reaction [Nicotine results in decreased expression of CDK4 protein] decreases expression
/ decreases reaction
protein 15231866
D009538 1019 CDK4
CMM3
PSK-J3
cyclin-dependent kinase 4 (EC:2.7.11.22) Nicotine promotes the reaction [CDK4 protein binds to CCND1 protein] affects binding
/ increases reaction
protein 18805435
D009538 1019 CDK4
CMM3
PSK-J3
cyclin-dependent kinase 4 (EC:2.7.11.22) Nicotine promotes the reaction [NFATC2 protein results in decreased expression of CDK4 protein] decreases expression
/ increases reaction
protein 15231866
D009538 1019 CDK4
CMM3
PSK-J3
cyclin-dependent kinase 4 (EC:2.7.11.22) Nicotine results in decreased expression of CDK4 protein decreases expression
protein 15231866
D009538 1019 CDK4
CMM3
PSK-J3
cyclin-dependent kinase 4 (EC:2.7.11.22) Tubocurarine inhibits the reaction [Nicotine results in decreased expression of CDK4 protein] decreases expression
/ decreases reaction
protein 15231866
D009538 1021 CDK6
PLSTIRE
cyclin-dependent kinase 6 (EC:2.7.11.22) Nicotine promotes the reaction [CDK6 protein binds to CCND1 protein] affects binding
/ increases reaction
protein 18805435
D009538 1021 CDK6
PLSTIRE
cyclin-dependent kinase 6 (EC:2.7.11.22) Nicotine results in increased expression of CDK6 mRNA increases expression
mRNA 16949557
D009538 1026 CDKN1A
CAP20
CDKN1
CIP1
MDA-6
P21
SDI1
WAF1
p21CIP1
cyclin-dependent kinase inhibitor 1A (p21, Cip1) 4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide inhibits the reaction [Nicotine results in decreased expression of CDKN1A protein] decreases expression
/ decreases reaction
protein 18805435
D009538 1026 CDKN1A
CAP20
CDKN1
CIP1
MDA-6
P21
SDI1
WAF1
p21CIP1
cyclin-dependent kinase inhibitor 1A (p21, Cip1) Nicotine inhibits the reaction [Cisplatin results in increased expression of CDKN1A protein] decreases reaction
/ increases expression
protein 16601104
D009538 1026 CDKN1A
CAP20
CDKN1
CIP1
MDA-6
P21
SDI1
WAF1
p21CIP1
cyclin-dependent kinase inhibitor 1A (p21, Cip1) Nicotine inhibits the reaction [gemcitabine results in increased expression of CDKN1A protein] decreases reaction
/ increases expression
protein 16601104
D009538 1026 CDKN1A
CAP20
CDKN1
CIP1
MDA-6
P21
SDI1
WAF1
p21CIP1
cyclin-dependent kinase inhibitor 1A (p21, Cip1) Nicotine inhibits the reaction [Paclitaxel results in increased expression of CDKN1A protein] decreases reaction
/ increases expression
protein 16601104
D009538 1026 CDKN1A
CAP20
CDKN1
CIP1
MDA-6
P21
SDI1
WAF1
p21CIP1
cyclin-dependent kinase inhibitor 1A (p21, Cip1) Nicotine results in decreased expression of CDKN1A protein decreases expression
protein 18805435
D009538 1026 CDKN1A
CAP20
CDKN1
CIP1
MDA-6
P21
SDI1
WAF1
p21CIP1
cyclin-dependent kinase inhibitor 1A (p21, Cip1) Nicotine results in increased expression of CDKN1A protein increases expression
protein 16011614
20727180
D009538 1027 CDKN1B
CDKN4
KIP1
MEN1B
MEN4
P27KIP1
cyclin-dependent kinase inhibitor 1B (p27, Kip1) 4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide inhibits the reaction [Nicotine results in decreased expression of CDKN1B protein] decreases expression
/ decreases reaction
protein 18805435
D009538 1027 CDKN1B
CDKN4
KIP1
MEN1B
MEN4
P27KIP1
cyclin-dependent kinase inhibitor 1B (p27, Kip1) Nicotine results in decreased expression of CDKN1B protein decreases expression
protein 18805435
D009538 1027 CDKN1B
CDKN4
KIP1
MEN1B
MEN4
P27KIP1
cyclin-dependent kinase inhibitor 1B (p27, Kip1) Nicotine results in increased expression of and results in increased stability of CDKN1B protein increases expression
/ increases stability
protein 15231866
D009538 1051 CEBPB
C/EBP-beta
CRP2
IL6DBP
LAP
LIP
NF-IL6
TCF5
CCAAT/enhancer binding protein (C/EBP), beta Nicotine results in increased expression of CEBPB mRNA increases expression
mRNA 18805435
D009538 1062 CENPE
CENP-E
KIF10
PPP1R61
centromere protein E, 312kDa Nicotine results in increased expression of CENPE mRNA increases expression
mRNA 16949557
D009538 1106 CHD2
EEOC
chromodomain helicase DNA binding protein 2 (EC:3.6.4.12) Nicotine results in increased expression of CHD2 mRNA increases expression
mRNA 16949557
D009538 1135 CHRNA2
cholinergic receptor, nicotinic, alpha 2 (neuronal) CHRNA2 gene mutant form affects the susceptibility to Nicotine affects response to substance
gene 19383498
D009538 1135 CHRNA2
cholinergic receptor, nicotinic, alpha 2 (neuronal) Nicotine results in increased activity of [CHRNB4 protein binds to CHRNA2 protein] affects binding
/ increases activity
protein 9454827
D009538 1136 CHRNA3
LNCR2
NACHRA3
PAOD2
cholinergic receptor, nicotinic, alpha 3 (neuronal) CHRNA3 protein affects the reaction [Nicotine results in increased expression of CHRNA5 mRNA] affects reaction
/ increases expression
protein 18450646
D009538 1136 CHRNA3
LNCR2
NACHRA3
PAOD2
cholinergic receptor, nicotinic, alpha 3 (neuronal) CHRNA3 protein affects the reaction [Nicotine results in increased expression of CHRNA5 protein] affects reaction
/ increases expression
protein 18450646
D009538 1136 CHRNA3
LNCR2
NACHRA3
PAOD2
cholinergic receptor, nicotinic, alpha 3 (neuronal) CHRNA3 protein affects the reaction [Nicotine results in increased expression of CHRNA7 mRNA] affects reaction
/ increases expression
protein 18450646
D009538 1136 CHRNA3
LNCR2
NACHRA3
PAOD2
cholinergic receptor, nicotinic, alpha 3 (neuronal) CHRNA3 protein affects the reaction [Nicotine results in increased expression of CHRNA7 protein] affects reaction
/ increases expression
protein 18450646
D009538 1136 CHRNA3
LNCR2
NACHRA3
PAOD2
cholinergic receptor, nicotinic, alpha 3 (neuronal) Nicotine results in decreased expression of CHRNA3 mRNA decreases expression
mRNA 12628473
D009538 1136 CHRNA3
LNCR2
NACHRA3
PAOD2
cholinergic receptor, nicotinic, alpha 3 (neuronal) Nicotine results in increased activity of [CHRNB4 protein binds to CHRNA3 protein] affects binding
/ increases activity
protein 9454827
D009538 1137 CHRNA4
BFNC
EBN
EBN1
NACHR
NACHRA4
NACRA4
cholinergic receptor, nicotinic, alpha 4 (neuronal) [Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein] affects binding
/ decreases activity
/ decreases reaction
/ increases phosphorylation
protein 18448488
D009538 1137 CHRNA4
BFNC
EBN
EBN1
NACHR
NACHRA4
NACRA4
cholinergic receptor, nicotinic, alpha 4 (neuronal) [Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein] affects binding
/ decreases activity
/ decreases reaction
/ increases phosphorylation
protein 18448488
D009538 1137 CHRNA4
BFNC
EBN
EBN1
NACHR
NACHRA4
NACRA4
cholinergic receptor, nicotinic, alpha 4 (neuronal) [Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of STAT3 protein] affects binding
/ decreases activity
/ decreases reaction
/ increases phosphorylation
protein 18448488
D009538 1137 CHRNA4
BFNC
EBN
EBN1
NACHR
NACHRA4
NACRA4
cholinergic receptor, nicotinic, alpha 4 (neuronal) Nicotine binds to [CHRNA4 protein binds to CHRNB2 protein] affects binding
protein 9336329
D009538 1137 CHRNA4
BFNC
EBN
EBN1
NACHR
NACHRA4
NACRA4
cholinergic receptor, nicotinic, alpha 4 (neuronal) Nicotine inhibits the reaction [cytisine binds to [CHRNA4 protein binds to CHRNB2 protein]] affects binding
/ decreases reaction
protein 9336329
D009538 1137 CHRNA4
BFNC
EBN
EBN1
NACHR
NACHRA4
NACRA4
cholinergic receptor, nicotinic, alpha 4 (neuronal) Nicotine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]] affects binding
/ decreases reaction
protein 14645658
D009538 1137 CHRNA4
BFNC
EBN
EBN1
NACHR
NACHRA4
NACRA4
cholinergic receptor, nicotinic, alpha 4 (neuronal) Nicotine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein] affects binding
/ increases activity
protein 14645658
D009538 1137 CHRNA4
BFNC
EBN
EBN1
NACHR
NACHRA4
NACRA4
cholinergic receptor, nicotinic, alpha 4 (neuronal) Nicotine results in increased activity of [CHRNB4 protein binds to CHRNA4 protein] affects binding
/ increases activity
protein 9454827
D009538 1137 CHRNA4
BFNC
EBN
EBN1
NACHR
NACHRA4
NACRA4
cholinergic receptor, nicotinic, alpha 4 (neuronal) Nicotine results in increased expression of CHRNA4 protein increases expression
protein 19139119
20106947
D009538 1137 CHRNA4
BFNC
EBN
EBN1
NACHR
NACHRA4
NACRA4
cholinergic receptor, nicotinic, alpha 4 (neuronal) rosiglitazone inhibits the reaction [Nicotine results in increased expression of CHRNA4 protein] decreases reaction
/ increases expression
protein 19139119
D009538 1138 CHRNA5
LNCR2
cholinergic receptor, nicotinic, alpha 5 (neuronal) 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Nicotine results in increased expression of CHRNA5 mRNA] decreases reaction
/ increases expression
mRNA 18450646
D009538 1138 CHRNA5
LNCR2
cholinergic receptor, nicotinic, alpha 5 (neuronal) 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Nicotine results in increased expression of CHRNA5 protein] decreases reaction
/ increases expression
protein 18450646
D009538 1138 CHRNA5
LNCR2
cholinergic receptor, nicotinic, alpha 5 (neuronal) 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Nicotine results in increased expression of CHRNA5 mRNA] decreases reaction
/ increases expression
mRNA 18450646
D009538 1138 CHRNA5
LNCR2
cholinergic receptor, nicotinic, alpha 5 (neuronal) 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Nicotine results in increased expression of CHRNA5 protein] decreases reaction
/ increases expression
protein 18450646
D009538 1138 CHRNA5
LNCR2
cholinergic receptor, nicotinic, alpha 5 (neuronal) 5-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone inhibits the reaction [Nicotine results in increased expression of CHRNA5 mRNA] decreases reaction
/ increases expression
mRNA 18450646
D009538 1138 CHRNA5
LNCR2
cholinergic receptor, nicotinic, alpha 5 (neuronal) 5-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone inhibits the reaction [Nicotine results in increased expression of CHRNA5 protein] decreases reaction
/ increases expression
protein 18450646
D009538 1138 CHRNA5
LNCR2
cholinergic receptor, nicotinic, alpha 5 (neuronal) alpha-conotoxin MII inhibits the reaction [Nicotine results in increased expression of CHRNA5 mRNA] decreases reaction
/ increases expression
mRNA 18450646
D009538 1138 CHRNA5
LNCR2
cholinergic receptor, nicotinic, alpha 5 (neuronal) alpha-conotoxin MII inhibits the reaction [Nicotine results in increased expression of CHRNA5 protein] decreases reaction
/ increases expression
protein 18450646
D009538 1138 CHRNA5
LNCR2
cholinergic receptor, nicotinic, alpha 5 (neuronal) CHRNA3 protein affects the reaction [Nicotine results in increased expression of CHRNA5 mRNA] affects reaction
/ increases expression
mRNA 18450646
D009538 1138 CHRNA5
LNCR2
cholinergic receptor, nicotinic, alpha 5 (neuronal) CHRNA3 protein affects the reaction [Nicotine results in increased expression of CHRNA5 protein] affects reaction
/ increases expression
protein 18450646
D009538 1138 CHRNA5
LNCR2
cholinergic receptor, nicotinic, alpha 5 (neuronal) CHRNA5 gene polymorphism results in increased susceptibility to Nicotine increases response to substance
gene 18519132
D009538 1138 CHRNA5
LNCR2
cholinergic receptor, nicotinic, alpha 5 (neuronal) CHRNA7 protein affects the reaction [Nicotine results in increased expression of CHRNA5 mRNA] affects reaction
/ increases expression
mRNA 18450646
D009538 1138 CHRNA5
LNCR2
cholinergic receptor, nicotinic, alpha 5 (neuronal) CHRNA7 protein affects the reaction [Nicotine results in increased expression of CHRNA5 protein] affects reaction
/ increases expression
protein 18450646
D009538 1138 CHRNA5
LNCR2
cholinergic receptor, nicotinic, alpha 5 (neuronal) Go 6976 inhibits the reaction [Nicotine results in increased expression of CHRNA5 mRNA] decreases reaction
/ increases expression
mRNA 18450646
D009538 1138 CHRNA5
LNCR2
cholinergic receptor, nicotinic, alpha 5 (neuronal) Go 6976 inhibits the reaction [Nicotine results in increased expression of CHRNA5 protein] decreases reaction
/ increases expression
protein 18450646
D009538 1138 CHRNA5
LNCR2
cholinergic receptor, nicotinic, alpha 5 (neuronal) KN 62 inhibits the reaction [Nicotine results in increased expression of CHRNA5 mRNA] decreases reaction
/ increases expression
mRNA 18450646
D009538 1138 CHRNA5
LNCR2
cholinergic receptor, nicotinic, alpha 5 (neuronal) KN 62 inhibits the reaction [Nicotine results in increased expression of CHRNA5 protein] decreases reaction
/ increases expression
protein 18450646
D009538 1138 CHRNA5
LNCR2
cholinergic receptor, nicotinic, alpha 5 (neuronal) manumycin inhibits the reaction [Nicotine results in increased expression of CHRNA5 mRNA] decreases reaction
/ increases expression
mRNA 18450646
D009538 1138 CHRNA5
LNCR2
cholinergic receptor, nicotinic, alpha 5 (neuronal) manumycin inhibits the reaction [Nicotine results in increased expression of CHRNA5 protein] decreases reaction
/ increases expression
protein 18450646
D009538 1138 CHRNA5
LNCR2
cholinergic receptor, nicotinic, alpha 5 (neuronal) Mecamylamine inhibits the reaction [Nicotine results in increased expression of CHRNA5 protein] decreases reaction
/ increases expression
protein 18450646
D009538 1138 CHRNA5
LNCR2
cholinergic receptor, nicotinic, alpha 5 (neuronal) Nicotine results in decreased expression of CHRNA5 mRNA decreases expression
mRNA 12628473
D009538 1138 CHRNA5
LNCR2
cholinergic receptor, nicotinic, alpha 5 (neuronal) Nicotine results in increased expression of CHRNA5 mRNA increases expression
mRNA 18450646
D009538 1138 CHRNA5
LNCR2
cholinergic receptor, nicotinic, alpha 5 (neuronal) Nicotine results in increased expression of CHRNA5 protein increases expression
protein 18450646
D009538 8973 CHRNA6
CHNRA6
cholinergic receptor, nicotinic, alpha 6 (neuronal) Nicotine results in decreased expression of CHRNA6 mRNA decreases expression
mRNA 12628473
D009538 1139 CHRNA7
CHRNA7-2
NACHRA7
cholinergic receptor, nicotinic, alpha 7 (neuronal) 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Nicotine results in increased expression of CHRNA7 mRNA] decreases reaction
/ increases expression
mRNA 18450646
D009538 1139 CHRNA7
CHRNA7-2
NACHRA7
cholinergic receptor, nicotinic, alpha 7 (neuronal) 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Nicotine results in increased expression of CHRNA7 protein] decreases reaction
/ increases expression
protein 18450646
D009538 1139 CHRNA7
CHRNA7-2
NACHRA7
cholinergic receptor, nicotinic, alpha 7 (neuronal) 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Nicotine results in increased expression of CHRNA7 mRNA] decreases reaction
/ increases expression
mRNA 18450646
D009538 1139 CHRNA7
CHRNA7-2
NACHRA7
cholinergic receptor, nicotinic, alpha 7 (neuronal) 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Nicotine results in increased expression of CHRNA7 protein] decreases reaction
/ increases expression
protein 18450646
D009538 1139 CHRNA7
CHRNA7-2
NACHRA7
cholinergic receptor, nicotinic, alpha 7 (neuronal) Bungarotoxins inhibits the reaction [Nicotine binds to and results in increased activity of CHRNA7 protein] affects binding
/ decreases reaction
/ increases activity
protein 12626641
D009538 1139 CHRNA7
CHRNA7-2
NACHRA7
cholinergic receptor, nicotinic, alpha 7 (neuronal) Bungarotoxins inhibits the reaction [Nicotine results in increased expression of CHRNA7 protein] decreases reaction
/ increases expression
protein 18450646
D009538 1139 CHRNA7
CHRNA7-2
NACHRA7
cholinergic receptor, nicotinic, alpha 7 (neuronal) CHRNA3 protein affects the reaction [Nicotine results in increased expression of CHRNA7 mRNA] affects reaction
/ increases expression
mRNA 18450646
D009538 1139 CHRNA7
CHRNA7-2
NACHRA7
cholinergic receptor, nicotinic, alpha 7 (neuronal) CHRNA3 protein affects the reaction [Nicotine results in increased expression of CHRNA7 protein] affects reaction
/ increases expression
protein 18450646
D009538 1139 CHRNA7
CHRNA7-2
NACHRA7
cholinergic receptor, nicotinic, alpha 7 (neuronal) CHRNA7 protein affects the reaction [Nicotine promotes the reaction [RB1 protein binds to RAF1 protein]] affects binding
/ affects reaction
/ increases reaction
protein 16862215
D009538 1139 CHRNA7
CHRNA7-2
NACHRA7
cholinergic receptor, nicotinic, alpha 7 (neuronal) CHRNA7 protein affects the reaction [Nicotine results in increased expression of CHRNA5 mRNA] affects reaction
/ increases expression
protein 18450646
D009538 1139 CHRNA7
CHRNA7-2
NACHRA7
cholinergic receptor, nicotinic, alpha 7 (neuronal) CHRNA7 protein affects the reaction [Nicotine results in increased expression of CHRNA5 protein] affects reaction
/ increases expression
protein 18450646
D009538 1139 CHRNA7
CHRNA7-2
NACHRA7
cholinergic receptor, nicotinic, alpha 7 (neuronal) CHRNA7 protein affects the reaction [Nicotine results in increased expression of GATA2 mRNA] affects reaction
/ increases expression
protein 18450646
D009538 1139 CHRNA7
CHRNA7-2
NACHRA7
cholinergic receptor, nicotinic, alpha 7 (neuronal) CHRNA7 protein affects the reaction [Nicotine results in increased expression of GATA2 protein] affects reaction
/ increases expression
protein 18450646
D009538 1139 CHRNA7
CHRNA7-2
NACHRA7
cholinergic receptor, nicotinic, alpha 7 (neuronal) CHRNA7 protein mutant form results in increased susceptibility to Nicotine increases response to substance
protein 10082212
D009538 1139 CHRNA7
CHRNA7-2
NACHRA7
cholinergic receptor, nicotinic, alpha 7 (neuronal) GATA2 protein affects the reaction [Nicotine results in increased expression of CHRNA7 mRNA] affects reaction
/ increases expression
mRNA 18450646
D009538 1139 CHRNA7
CHRNA7-2
NACHRA7
cholinergic receptor, nicotinic, alpha 7 (neuronal) GATA2 protein affects the reaction [Nicotine results in increased expression of CHRNA7 protein] affects reaction
/ increases expression
protein 18450646
D009538 1139 CHRNA7
CHRNA7-2
NACHRA7
cholinergic receptor, nicotinic, alpha 7 (neuronal) KN 62 inhibits the reaction [Nicotine results in increased expression of CHRNA7 mRNA] decreases reaction
/ increases expression
mRNA 18450646
D009538 1139 CHRNA7
CHRNA7-2
NACHRA7
cholinergic receptor, nicotinic, alpha 7 (neuronal) KN 62 inhibits the reaction [Nicotine results in increased expression of CHRNA7 protein] decreases reaction
/ increases expression
protein 18450646
D009538 1139 CHRNA7
CHRNA7-2
NACHRA7
cholinergic receptor, nicotinic, alpha 7 (neuronal) [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased abundance of Epinephrine] affects binding
/ decreases activity
/ decreases reaction
/ increases abundance
protein 17498763
D009538 1139 CHRNA7
CHRNA7-2
NACHRA7
cholinergic receptor, nicotinic, alpha 7 (neuronal) [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased expression of DBH mRNA] affects binding
/ decreases activity
/ decreases reaction
/ increases expression
protein 17498763
D009538 1139 CHRNA7
CHRNA7-2
NACHRA7
cholinergic receptor, nicotinic, alpha 7 (neuronal) [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased expression of TH mRNA] affects binding
/ decreases activity
/ decreases reaction
/ increases expression
protein 17498763
D009538 1139 CHRNA7
CHRNA7-2
NACHRA7
cholinergic receptor, nicotinic, alpha 7 (neuronal) [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein] affects binding
/ decreases activity
/ decreases reaction
/ increases phosphorylation
protein 18448488
D009538 1139 CHRNA7
CHRNA7-2
NACHRA7
cholinergic receptor, nicotinic, alpha 7 (neuronal) [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein] affects binding
/ decreases activity
/ decreases reaction
/ increases phosphorylation
protein 18448488
D009538 1139 CHRNA7
CHRNA7-2
NACHRA7
cholinergic receptor, nicotinic, alpha 7 (neuronal) [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased phosphorylation of STAT3 protein] affects binding
/ decreases activity
/ decreases reaction
/ increases phosphorylation
protein 18448488
D009538 1139 CHRNA7
CHRNA7-2
NACHRA7
cholinergic receptor, nicotinic, alpha 7 (neuronal) methyllycaconitine inhibits the reaction [Nicotine binds to and results in increased activity of CHRNA7 protein] affects binding
/ decreases reaction
/ increases activity
protein 12626641
D009538 1139 CHRNA7
CHRNA7-2
NACHRA7
cholinergic receptor, nicotinic, alpha 7 (neuronal) methyllycaconitine promotes the reaction [[Nicotine results in increased activity of CHRNA7 protein] which results in increased transport of Calcium] increases activity
/ increases reaction
/ increases transport
protein 17709503
D009538 1139 CHRNA7
CHRNA7-2
NACHRA7
cholinergic receptor, nicotinic, alpha 7 (neuronal) Nicotine binds to and results in increased activity of CHRNA7 protein affects binding
/ increases activity
protein 9336329
12626641
D009538 1139 CHRNA7
CHRNA7-2
NACHRA7
cholinergic receptor, nicotinic, alpha 7 (neuronal) Nicotine inhibits the reaction [Bungarotoxins binds to CHRNA7 protein] affects binding
/ decreases reaction
protein 9336329
10216184
D009538 1139 CHRNA7
CHRNA7-2
NACHRA7
cholinergic receptor, nicotinic, alpha 7 (neuronal) Nicotine results in decreased expression of CHRNA7 mRNA decreases expression
mRNA 12628473
D009538 1139 CHRNA7
CHRNA7-2
NACHRA7
cholinergic receptor, nicotinic, alpha 7 (neuronal) Nicotine results in increased activity of CHRNA7 protein increases activity
protein 10082212
17709503
D009538 1139 CHRNA7
CHRNA7-2
NACHRA7
cholinergic receptor, nicotinic, alpha 7 (neuronal) [Nicotine results in increased activity of CHRNA7 protein] which results in increased transport of Calcium increases activity
/ increases transport
protein 17709503
D009538 1139 CHRNA7
CHRNA7-2
NACHRA7
cholinergic receptor, nicotinic, alpha 7 (neuronal) Nicotine results in increased expression of and results in increased phosphorylation of CHRNA7 protein increases expression
/ increases phosphorylation
protein 17709503
D009538 1139 CHRNA7
CHRNA7-2
NACHRA7
cholinergic receptor, nicotinic, alpha 7 (neuronal) Nicotine results in increased expression of CHRNA7 increases expression
10216184
D009538 1139 CHRNA7
CHRNA7-2
NACHRA7
cholinergic receptor, nicotinic, alpha 7 (neuronal) Nicotine results in increased expression of CHRNA7 mRNA increases expression
mRNA 17151781
18450646
D009538 1139 CHRNA7
CHRNA7-2
NACHRA7
cholinergic receptor, nicotinic, alpha 7 (neuronal) Nicotine results in increased expression of CHRNA7 protein increases expression
protein 17459420
18450646
20106947
D009538 1141 CHRNB2
EFNL3
nAChRB2
cholinergic receptor, nicotinic, beta 2 (neuronal) [Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein] affects binding
/ decreases activity
/ decreases reaction
/ increases phosphorylation
protein 18448488
D009538 1141 CHRNB2
EFNL3
nAChRB2
cholinergic receptor, nicotinic, beta 2 (neuronal) [Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein] affects binding
/ decreases activity
/ decreases reaction
/ increases phosphorylation
protein 18448488
D009538 1141 CHRNB2
EFNL3
nAChRB2
cholinergic receptor, nicotinic, beta 2 (neuronal) [Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of STAT3 protein] affects binding
/ decreases activity
/ decreases reaction
/ increases phosphorylation
protein 18448488
D009538 1141 CHRNB2
EFNL3
nAChRB2
cholinergic receptor, nicotinic, beta 2 (neuronal) Nicotine binds to [CHRNA4 protein binds to CHRNB2 protein] affects binding
protein 9336329
D009538 1141 CHRNB2
EFNL3
nAChRB2
cholinergic receptor, nicotinic, beta 2 (neuronal) Nicotine inhibits the reaction [cytisine binds to [CHRNA4 protein binds to CHRNB2 protein]] affects binding
/ decreases reaction
protein 9336329
D009538 1141 CHRNB2
EFNL3
nAChRB2
cholinergic receptor, nicotinic, beta 2 (neuronal) Nicotine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]] affects binding
/ decreases reaction
protein 14645658
D009538 1141 CHRNB2
EFNL3
nAChRB2
cholinergic receptor, nicotinic, beta 2 (neuronal) Nicotine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein] affects binding
/ increases activity
protein 14645658
D009538 1141 CHRNB2
EFNL3
nAChRB2
cholinergic receptor, nicotinic, beta 2 (neuronal) Nicotine results in increased expression of CHRNB2 mRNA increases expression
mRNA 20457658
D009538 1143 CHRNB4
cholinergic receptor, nicotinic, beta 4 (neuronal) Nicotine results in increased activity of [CHRNB4 protein binds to CHRNA2 protein] affects binding
/ increases activity
protein 9454827
D009538 1143 CHRNB4
cholinergic receptor, nicotinic, beta 4 (neuronal) Nicotine results in increased activity of [CHRNB4 protein binds to CHRNA3 protein] affects binding
/ increases activity
protein 9454827
D009538 1143 CHRNB4
cholinergic receptor, nicotinic, beta 4 (neuronal) Nicotine results in increased activity of [CHRNB4 protein binds to CHRNA4 protein] affects binding
/ increases activity
protein 9454827
D009538 1160 CKMT2
SMTCK
creatine kinase, mitochondrial 2 (sarcomeric) (EC:2.7.3.2) Nicotine results in decreased expression of CKMT2 mRNA decreases expression
mRNA 16949557
D009538 100196409 Nicotine results in decreased expression of CKS1 mRNA decreases expression
mRNA 18247414
D009538 1164 CKS2
CKSHS2
CDC28 protein kinase regulatory subunit 2 Nicotine results in increased expression of CKS2 mRNA increases expression
mRNA 16949557
D009538 23155 CLCC1
MCLC
chloride channel CLIC-like 1 Nicotine results in increased expression of CLCC1 mRNA increases expression
mRNA 16949557
D009538 1182 CLCN3
CLC3
ClC-3
chloride channel, voltage-sensitive 3 Nicotine results in increased expression of CLCN3 mRNA increases expression
mRNA 16949557
D009538 1192 CLIC1
G6
NCC27
chloride intracellular channel 1 Nicotine results in decreased expression of CLIC1 mRNA decreases expression
mRNA 16949557
D009538 1272 CNTN1
F3
GP135
contactin 1 alpha-cobratoxin inhibits the reaction [Nicotine results in decreased expression of CNTN1 mRNA] decreases expression
/ decreases reaction
mRNA 12588870
D009538 1272 CNTN1
F3
GP135
contactin 1 alpha-cobratoxin inhibits the reaction [Nicotine results in increased expression of CNTN1 mRNA] decreases reaction
/ increases expression
mRNA 16949557
D009538 1272 CNTN1
F3
GP135
contactin 1 Mecamylamine inhibits the reaction [Nicotine results in decreased expression of CNTN1 mRNA] decreases expression
/ decreases reaction
mRNA 12588870
D009538 1272 CNTN1
F3
GP135
contactin 1 Mecamylamine inhibits the reaction [Nicotine results in increased expression of CNTN1 mRNA] decreases reaction
/ increases expression
mRNA 16949557
D009538 1272 CNTN1
F3
GP135
contactin 1 Nicotine results in decreased expression of CNTN1 mRNA decreases expression
mRNA 12588870
D009538 1272 CNTN1
F3
GP135
contactin 1 Nicotine results in increased expression of CNTN1 mRNA increases expression
mRNA 16949557
D009538 1272 CNTN1
F3
GP135
contactin 1 Tubocurarine inhibits the reaction [Nicotine results in decreased expression of CNTN1 mRNA] decreases expression
/ decreases reaction
mRNA 12588870
D009538 1272 CNTN1
F3
GP135
contactin 1 Tubocurarine inhibits the reaction [Nicotine results in increased expression of CNTN1 mRNA] decreases reaction
/ increases expression
mRNA 16949557
D009538 1382 CRABP2
CRABP-II
RBP6
cellular retinoic acid binding protein 2 Nicotine results in decreased expression of CRABP2 mRNA decreases expression
mRNA 16949557
D009538 1385 CREB1
CREB
cAMP responsive element binding protein 1 Nicotine results in decreased expression of CREB1 mRNA decreases expression
mRNA 18247414
D009538 1437 CSF2
GMCSF
colony stimulating factor 2 (granulocyte-macrophage) Nicotine results in increased expression of and results in increased secretion of CSF2 protein increases expression
/ increases secretion
protein 18082304
D009538 1437 CSF2
GMCSF
colony stimulating factor 2 (granulocyte-macrophage) Nicotine results in increased secretion of CSF2 protein increases secretion
protein 9606035
D009538 1437 CSF2
GMCSF
colony stimulating factor 2 (granulocyte-macrophage) Tubocurarine inhibits the reaction [Nicotine results in increased secretion of CSF2 protein] decreases reaction
/ increases secretion
protein 9606035
D009538 3579 CXCR2
CD182
CDw128b
CMKAR2
IL8R2
IL8RA
IL8RB
chemokine (C-X-C motif) receptor 2 Nicotine results in decreased expression of CXCR2 mRNA decreases expression
mRNA 18247414
D009538 3579 CXCR2
CD182
CDw128b
CMKAR2
IL8R2
IL8RA
IL8RB
chemokine (C-X-C motif) receptor 2 Nicotine results in increased expression of CXCR2 mRNA increases expression
mRNA 20457658
D009538 2833 CXCR3
CD182
CD183
CKR-L2
CMKAR3
GPR9
IP10-R
Mig-R
MigR
chemokine (C-X-C motif) receptor 3 Nicotine results in increased expression of CXCR3 mRNA increases expression
mRNA 20457658
D009538 7852 CXCR4
CD184
D2S201E
FB22
HM89
HSY3RR
LAP3
LCR1
LESTR
NPY3R
NPYR
NPYRL
NPYY3R
WHIM
chemokine (C-X-C motif) receptor 4 [Mecamylamine co-treated with Dihydro-beta-Erythroidine co-treated with Bungarotoxins] inhibits the reaction [Nicotine results in increased expression of CXCR4 protein] affects cotreatment
/ decreases reaction
/ increases expression
protein 20457658
D009538 7852 CXCR4
CD184
D2S201E
FB22
HM89
HSY3RR
LAP3
LCR1
LESTR
NPY3R
NPYR
NPYRL
NPYY3R
WHIM
chemokine (C-X-C motif) receptor 4 Nicotine results in increased expression of CXCR4 mRNA increases expression
mRNA 20457658
D009538 7852 CXCR4
CD184
D2S201E
FB22
HM89
HSY3RR
LAP3
LCR1
LESTR
NPY3R
NPYR
NPYRL
NPYY3R
WHIM
chemokine (C-X-C motif) receptor 4 Nicotine results in increased expression of CXCR4 protein increases expression
protein 20457658
D009538 54205 CYCS
CYC
HCS
THC4
cytochrome c, somatic Nicotine inhibits the reaction [1-Methyl-4-phenylpyridinium affects the localization of CYCS protein] affects localization
/ decreases reaction
protein 15985439
D009538 54205 CYCS
CYC
HCS
THC4
cytochrome c, somatic Nicotine results in decreased secretion of CYCS protein decreases secretion
protein 11701223
D009538 1583 CYP11A1
CYP11A
CYPXIA1
P450SCC
cytochrome P450, family 11, subfamily A, polypeptide 1 (EC:1.14.15.6) Nicotine results in decreased expression of CYP11A1 mRNA decreases expression
mRNA 21971485
D009538 1583 CYP11A1
CYP11A
CYPXIA1
P450SCC
cytochrome P450, family 11, subfamily A, polypeptide 1 (EC:1.14.15.6) Nicotine results in decreased expression of CYP11A1 protein decreases expression
protein 21971485
D009538 1543 CYP1A1
AHH
AHRR
CP11
CYP1
P1-450
P450-C
P450DX
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) Nicotine results in increased expression of CYP1A1 protein increases expression
protein 11849738
D009538 1544 CYP1A2
CP12
P3-450
P450(PA)
cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) Nicotine results in decreased activity of CYP1A2 protein decreases activity
protein 15916432
D009538 1544 CYP1A2
CP12
P3-450
P450(PA)
cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) Nicotine results in increased expression of CYP1A2 protein increases expression
protein 11849738
D009538 1592 CYP26A1
CP26
CYP26
P450RAI
P450RAI1
cytochrome P450, family 26, subfamily A, polypeptide 1 (EC:1.14.-.-) Nicotine results in decreased expression of CYP26A1 mRNA decreases expression
mRNA 21371177
D009538 1592 CYP26A1
CP26
CYP26
P450RAI
P450RAI1
cytochrome P450, family 26, subfamily A, polypeptide 1 (EC:1.14.-.-) Nicotine results in decreased expression of CYP26A1 protein decreases expression
protein 21371177
D009538 1553 CYP2A13
CPAD
CYP2A
CYPIIA13
cytochrome P450, family 2, subfamily A, polypeptide 13 (EC:1.14.14.1) CYP2A13 protein results in increased metabolism of Nicotine increases metabolic processing
protein 22743290
D009538 1553 CYP2A13
CPAD
CYP2A
CYPIIA13
cytochrome P450, family 2, subfamily A, polypeptide 13 (EC:1.14.14.1) Nicotine inhibits the reaction [CYP2A13 protein results in increased susceptibility to Aflatoxin B1] decreases reaction
/ increases response to substance
protein 22743290
D009538 1548 CYP2A6
CPA6
CYP2A
CYP2A3
CYPIIA6
P450C2A
P450PB
cytochrome P450, family 2, subfamily A, polypeptide 6 (EC:1.14.14.1) CYP2A6 exon SNP results in decreased oxidation of Nicotine decreases oxidation
exon 11237731
D009538 1548 CYP2A6
CPA6
CYP2A
CYP2A3
CYPIIA6
P450C2A
P450PB
cytochrome P450, family 2, subfamily A, polypeptide 6 (EC:1.14.14.1) CYP2A6 gene mutant form results in decreased metabolism of Nicotine decreases metabolic processing
gene 10448083
10668854
D009538 1548 CYP2A6
CPA6
CYP2A
CYP2A3
CYPIIA6
P450C2A
P450PB
cytochrome P450, family 2, subfamily A, polypeptide 6 (EC:1.14.14.1) CYP2A6 gene mutant form results in decreased oxidation of Nicotine decreases oxidation
gene 20012030
D009538 1548 CYP2A6
CPA6
CYP2A
CYP2A3
CYPIIA6
P450C2A
P450PB
cytochrome P450, family 2, subfamily A, polypeptide 6 (EC:1.14.14.1) CYP2A6 gene polymorphism affects the metabolism of and affects the abundance of Nicotine affects abundance
/ affects metabolic processing
gene 16141602
D009538 1548 CYP2A6
CPA6
CYP2A
CYP2A3
CYPIIA6
P450C2A
P450PB
cytochrome P450, family 2, subfamily A, polypeptide 6 (EC:1.14.14.1) CYP2A6 gene polymorphism affects the metabolism of Nicotine affects metabolic processing
gene 11180041
11434509
16372023
16402086
16636685
16952495
D009538 1548 CYP2A6
CPA6
CYP2A
CYP2A3
CYPIIA6
P450C2A
P450PB
cytochrome P450, family 2, subfamily A, polypeptide 6 (EC:1.14.14.1) CYP2A6 gene polymorphism affects the oxidation of Nicotine affects oxidation
gene 10663384
15900015
D009538 1548 CYP2A6
CPA6
CYP2A
CYP2A3
CYPIIA6
P450C2A
P450PB
cytochrome P450, family 2, subfamily A, polypeptide 6 (EC:1.14.14.1) CYP2A6 gene polymorphism results in increased metabolism of Nicotine increases metabolic processing
gene 17522595
D009538 1548 CYP2A6
CPA6
CYP2A
CYP2A3
CYPIIA6
P450C2A
P450PB
cytochrome P450, family 2, subfamily A, polypeptide 6 (EC:1.14.14.1) CYP2A6 gene SNP results in decreased metabolism of Nicotine decreases metabolic processing
gene 12445030
D009538 1548 CYP2A6
CPA6
CYP2A
CYP2A3
CYPIIA6
P450C2A
P450PB
cytochrome P450, family 2, subfamily A, polypeptide 6 (EC:1.14.14.1) CYP2A6 protein affects the metabolism of Nicotine affects metabolic processing
protein 15980104
D009538 1548 CYP2A6
CPA6
CYP2A
CYP2A3
CYPIIA6
P450C2A
P450PB
cytochrome P450, family 2, subfamily A, polypeptide 6 (EC:1.14.14.1) CYP2A6 protein mutant form affects the metabolism of Nicotine affects metabolic processing
protein 15980104
D009538 1548 CYP2A6
CPA6
CYP2A
CYP2A3
CYPIIA6
P450C2A
P450PB
cytochrome P450, family 2, subfamily A, polypeptide 6 (EC:1.14.14.1) CYP2A6 protein results in increased metabolism of and results in decreased activity of Nicotine decreases activity
/ increases metabolic processing
protein 10999944
11259349
11805739
17035386
D009538 1548 CYP2A6
CPA6
CYP2A
CYP2A3
CYPIIA6
P450C2A
P450PB
cytochrome P450, family 2, subfamily A, polypeptide 6 (EC:1.14.14.1) CYP2A6 protein results in increased metabolism of Nicotine increases metabolic processing
protein 10911933
11353760
11434509
11779172
12024803
12406643
12464242
12487152
12488541
12844137
15592323
15671201
15735609
15861044
16141602
16402086
16636685
17112802
17220563
17454707
17979512
18004205
18041664
18216723
22486895
D009538 1548 CYP2A6
CPA6
CYP2A
CYP2A3
CYPIIA6
P450C2A
P450PB
cytochrome P450, family 2, subfamily A, polypeptide 6 (EC:1.14.14.1) CYP2A6 protein results in increased oxidation of Nicotine increases oxidation
protein 11684323
12504349
15225612
15900015
15940289
18360915
D009538 1548 CYP2A6
CPA6
CYP2A
CYP2A3
CYPIIA6
P450C2A
P450PB
cytochrome P450, family 2, subfamily A, polypeptide 6 (EC:1.14.14.1) CYP2B6 gene polymorphism affects the reaction [CYP2A6 protein results in increased metabolism of Nicotine] affects reaction
/ increases metabolic processing
protein 18004205
D009538 1548 CYP2A6
CPA6
CYP2A
CYP2A3
CYPIIA6
P450C2A
P450PB
cytochrome P450, family 2, subfamily A, polypeptide 6 (EC:1.14.14.1) Tranylcypromine inhibits the reaction [CYP2A6 protein results in increased metabolism of Nicotine] decreases reaction
/ increases metabolic processing
protein 11353760
D009538 1555 CYP2B6
CPB6
CYP2B
CYP2B7
CYP2B7P
CYPIIB6
EFVM
IIB1
P450
cytochrome P450, family 2, subfamily B, polypeptide 6 (EC:1.14.14.1) CYP2B6 gene polymorphism affects the reaction [CYP2A6 protein results in increased metabolism of Nicotine] affects reaction
/ increases metabolic processing
gene 18004205
D009538 1555 CYP2B6
CPB6
CYP2B
CYP2B7
CYP2B7P
CYPIIB6
EFVM
IIB1
P450
cytochrome P450, family 2, subfamily B, polypeptide 6 (EC:1.14.14.1) CYP2B6 protein results in increased metabolism of Nicotine increases metabolic processing
protein 12488541
D009538 1576 CYP3A4
CP33
CP34
CYP3A
CYP3A3
CYPIIIA3
CYPIIIA4
HLP
NF-25
P450C3
P450PCN1
cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) [Nicotine binds to CYP3A4 promoter] which results in increased expression of CYP3A4 mRNA affects binding
/ increases expression
mRNA / promoter 12851153
D009538 1621 DBH
DBM
dopamine beta-hydroxylase (dopamine beta-monooxygenase) (EC:1.14.17.1) [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased expression of DBH mRNA] affects binding
/ decreases activity
/ decreases reaction
/ increases expression
mRNA 17498763
D009538 1621 DBH
DBM
dopamine beta-hydroxylase (dopamine beta-monooxygenase) (EC:1.14.17.1) Nicotine results in increased expression of DBH mRNA increases expression
mRNA 17498763
D009538 54876 DCAF16
C4orf30
DDB1 and CUL4 associated factor 16 Nicotine results in increased expression of DCAF16 mRNA increases expression
mRNA 16949557
D009538 1642 DDB1
DDBA
UV-DDB1
XAP1
XPCE
XPE
XPE-BF
damage-specific DNA binding protein 1, 127kDa Nicotine results in decreased expression of DDB1 mRNA decreases expression
mRNA 16949557
D009538 1649 DDIT3
CEBPZ
CHOP
CHOP-10
CHOP10
GADD153
DNA-damage-inducible transcript 3 Nicotine inhibits the reaction [Cisplatin results in increased expression of DDIT3 mRNA] decreases reaction
/ increases expression
mRNA 11592233
D009538 10521 DDX17
P72
RH70
DEAD (Asp-Glu-Ala-Asp) box helicase 17 (EC:3.6.4.13) Nicotine results in increased expression of DDX17 mRNA increases expression
mRNA 16949557
D009538 9191 DEDD
CASP8IP1
DEDD1
DEFT
FLDED1
death effector domain containing Nicotine results in decreased expression of DEDD mRNA decreases expression
mRNA 18247414
D009538 1677 DFFB
CAD
CPAN
DFF-40
DFF2
DFF40
DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase) Nicotine results in decreased expression of DFFB mRNA decreases expression
mRNA 18247414
D009538 1719 DHFR
DHFRP1
DYR
dihydrofolate reductase (EC:1.5.1.3) alpha-cobratoxin inhibits the reaction [Nicotine results in decreased expression of DHFR mRNA] decreases expression
/ decreases reaction
mRNA 12588870
D009538 1719 DHFR
DHFRP1
DYR
dihydrofolate reductase (EC:1.5.1.3) Mecamylamine inhibits the reaction [Nicotine results in decreased expression of DHFR mRNA] decreases expression
/ decreases reaction
mRNA 12588870
D009538 1719 DHFR
DHFRP1
DYR
dihydrofolate reductase (EC:1.5.1.3) Nicotine results in decreased expression of DHFR mRNA decreases expression
mRNA 12588870
D009538 1719 DHFR
DHFRP1
DYR
dihydrofolate reductase (EC:1.5.1.3) Tubocurarine inhibits the reaction [Nicotine results in decreased expression of DHFR mRNA] decreases expression
/ decreases reaction
mRNA 12588870
D009538 1725 DHPS
DHS
DS
MIG13
deoxyhypusine synthase (EC:2.5.1.46) Nicotine results in decreased expression of DHPS mRNA decreases expression
mRNA 16949557
D009538 1777 DNASE2
DNASE2A
DNL
DNL2
deoxyribonuclease II, lysosomal (EC:3.1.22.1) Nicotine results in decreased expression of DNASE2 mRNA decreases expression
mRNA 18247414
D009538 10059 DNM1L
DLP1
DRP1
DVLP
DYMPLE
EMPF
HDYNIV
dynamin 1-like (EC:3.6.5.5) Nicotine results in increased expression of DNM1L protein increases expression
protein 21554491
D009538 1841 DTYMK
CDC8
PP3731
TMPK
TYMK
deoxythymidylate kinase (thymidylate kinase) (EC:2.7.4.9) Nicotine results in decreased expression of DTYMK mRNA decreases expression
mRNA 16949557
D009538 1856 DVL2
dishevelled segment polarity protein 2 Nicotine results in decreased expression of DVL2 mRNA decreases expression
mRNA 16949557
D009538 1783 DYNC1LI2
DNCLI2
LIC2
dynein, cytoplasmic 1, light intermediate chain 2 Nicotine results in increased expression of DYNC1LI2 mRNA increases expression
mRNA 16949557
D009538 1869 E2F1
E2F-1
RBAP1
RBBP3
RBP3
E2F transcription factor 1 L 663536 inhibits the reaction [Nicotine results in increased expression of E2F1 protein] decreases reaction
/ increases expression
protein 20061081
D009538 1869 E2F1
E2F-1
RBAP1
RBBP3
RBP3
E2F transcription factor 1 Nicotine promotes the reaction [E2F1 protein binds to BIRC5 promoter] affects binding
/ increases reaction
protein 16601104
D009538 1869 E2F1
E2F-1
RBAP1
RBBP3
RBP3
E2F transcription factor 1 Nicotine promotes the reaction [E2F1 protein binds to CDC25A promoter] affects binding
/ increases reaction
protein 16862215
D009538 1869 E2F1
E2F-1
RBAP1
RBBP3
RBP3
E2F transcription factor 1 Nicotine promotes the reaction [E2F1 protein binds to CDC6 promoter] affects binding
/ increases reaction
protein 16862215
D009538 1869 E2F1
E2F-1
RBAP1
RBBP3
RBP3
E2F transcription factor 1 Nicotine results in increased expression of E2F1 protein increases expression
protein 20061081
D009538 1870 E2F2
E2F-2
E2F transcription factor 2 Nicotine promotes the reaction [E2F2 protein binds to CDC25A promoter] affects binding
/ increases reaction
protein 16862215
D009538 1870 E2F2
E2F-2
E2F transcription factor 2 Nicotine promotes the reaction [E2F2 protein binds to CDC6 promoter] affects binding
/ increases reaction
protein 16862215
D009538 1871 E2F3
E2F-3
E2F transcription factor 3 Nicotine promotes the reaction [E2F3 protein binds to CDC25A promoter] affects binding
/ increases reaction
protein 16862215
D009538 1871 E2F3
E2F-3
E2F transcription factor 3 Nicotine promotes the reaction [E2F3 protein binds to CDC6 promoter] affects binding
/ increases reaction
protein 16862215
D009538 1874 E2F4
E2F-4
E2F transcription factor 4, p107/p130-binding Nicotine inhibits the reaction [E2F4 protein binds to CDC25A promoter] affects binding
/ decreases reaction
protein 16862215
D009538 1874 E2F4
E2F-4
E2F transcription factor 4, p107/p130-binding Nicotine inhibits the reaction [E2F4 protein binds to CDC6 promoter] affects binding
/ decreases reaction
protein 16862215
D009538 1875 E2F5
E2F-5
E2F transcription factor 5, p130-binding Nicotine inhibits the reaction [E2F5 protein binds to CDC25A promoter] affects binding
/ decreases reaction
protein 16862215
D009538 1875 E2F5
E2F-5
E2F transcription factor 5, p130-binding Nicotine inhibits the reaction [E2F5 protein binds to CDC6 promoter] affects binding
/ decreases reaction
protein 16862215
D009538 1909 EDNRA
ET-A
ETA
ETA-R
ETAR
ETRA
hET-AR
endothelin receptor type A Nicotine results in decreased expression of EDNRA mRNA decreases expression
mRNA 18247414
D009538 1938 EEF2
EEF-2
EF-2
EF2
SCA26
eukaryotic translation elongation factor 2 Nicotine results in increased expression of EEF2 protein modified form increases expression
protein 21554491
D009538 1938 EEF2
EEF-2
EF-2
EF2
SCA26
eukaryotic translation elongation factor 2 [Nicotine results in increased expression of UBA2 protein] which results in increased sumoylation of EEF2 protein increases expression
/ increases sumoylation
protein 21554491
D009538 1956 EGFR
ERBB
ERBB1
HER1
PIG61
mENA
epidermal growth factor receptor (EC:2.7.10.1) AG 1879 inhibits the reaction [Nicotine results in increased phosphorylation of EGFR protein] decreases reaction
/ increases phosphorylation
protein 14569062
D009538 1956 EGFR
ERBB
ERBB1
HER1
PIG61
mENA
epidermal growth factor receptor (EC:2.7.10.1) Nicotine results in increased phosphorylation of EGFR protein increases phosphorylation
protein 14569062
D009538 5610 EIF2AK2
EIF2AK1
PKR
PRKR
eukaryotic translation initiation factor 2-alpha kinase 2 (EC:2.7.11.1 2.7.10.2) Nicotine results in increased expression of EIF2AK2 mRNA increases expression
mRNA 16949557
D009538 1978 EIF4EBP1
4E-BP1
4EBP1
BP-1
PHAS-I
eukaryotic translation initiation factor 4E binding protein 1 [Nicotine results in increased phosphorylation of and results in increased activity of AKT1 protein] which results in increased phosphorylation of EIF4EBP1 protein increases activity
/ increases phosphorylation
protein 12511591
D009538 27436 EML4
C2orf2
ELP120
EMAP-4
EMAPL4
ROPP120
echinoderm microtubule associated protein like 4 alpha-cobratoxin inhibits the reaction [Nicotine results in decreased expression of EML4 mRNA] decreases expression
/ decreases reaction
mRNA 12588870
D009538 27436 EML4
C2orf2
ELP120
EMAP-4
EMAPL4
ROPP120
echinoderm microtubule associated protein like 4 Mecamylamine promotes the reaction [Nicotine results in decreased expression of EML4 mRNA] decreases expression
/ increases reaction
mRNA 12588870
D009538 27436 EML4
C2orf2
ELP120
EMAP-4
EMAPL4
ROPP120
echinoderm microtubule associated protein like 4 Nicotine results in decreased expression of EML4 mRNA decreases expression
mRNA 12588870
D009538 27436 EML4
C2orf2
ELP120
EMAP-4
EMAPL4
ROPP120
echinoderm microtubule associated protein like 4 Tubocurarine inhibits the reaction [Nicotine results in decreased expression of EML4 mRNA] decreases expression
/ decreases reaction
mRNA 12588870
D009538 2042 EPHA3
EK4
ETK
ETK1
HEK
HEK4
TYRO4
EPH receptor A3 (EC:2.7.10.1) Nicotine results in decreased expression of EPHA3 mRNA decreases expression
mRNA 18247414
D009538 2049 EPHB3
ETK2
HEK2
TYRO6
EPH receptor B3 (EC:2.7.10.1) Nicotine results in decreased expression of EPHB3 mRNA decreases expression
mRNA 18247414
D009538 2056 EPO
EP
MVCD2
erythropoietin Nicotine results in increased expression of EPO mRNA increases expression
mRNA 18247414
D009538 7430 EZR
CVIL
CVL
VIL2
ezrin Nicotine results in increased expression of EZR mRNA increases expression
mRNA 18247414
D009538 2147 F2
PT
RPRGL2
THPH1
coagulation factor II (thrombin) (EC:3.4.21.5) Nicotine results in increased expression of F2 mRNA increases expression
mRNA 18805435
D009538 355 FAS
ALPS1A
APO-1
APT1
CD95
FAS1
FASTM
TNFRSF6
Fas cell surface death receptor Nicotine results in increased expression of FAS mRNA increases expression
mRNA 20383341
D009538 355 FAS
ALPS1A
APO-1
APT1
CD95
FAS1
FASTM
TNFRSF6
Fas cell surface death receptor Nicotine results in increased expression of FAS protein increases expression
protein 20383341
D009538 356 FASLG
ALPS1B
APT1LG1
APTL
CD178
CD95-L
CD95L
FASL
TNFSF6
Fas ligand (TNF superfamily, member 6) Nicotine results in increased expression of FASLG mRNA increases expression
mRNA 18247414
19896492
20383341
D009538 356 FASLG
ALPS1B
APT1LG1
APTL
CD178
CD95-L
CD95L
FASL
TNFSF6
Fas ligand (TNF superfamily, member 6) Nicotine results in increased expression of FASLG protein increases expression
protein 20383341
D009538 2195 FAT1
CDHF7
CDHR8
FAT
ME5
hFat1
FAT atypical cadherin 1 Nicotine results in increased expression of FAT1 mRNA increases expression
mRNA 16949557
D009538 9638 FEZ1
fasciculation and elongation protein zeta 1 (zygin I) alpha-cobratoxin promotes the reaction [Nicotine results in decreased expression of FEZ1 mRNA alternative form] decreases expression
/ increases reaction
mRNA 12588870
D009538 9638 FEZ1
fasciculation and elongation protein zeta 1 (zygin I) Nicotine results in decreased expression of FEZ1 mRNA decreases expression
mRNA 12588870
D009538 9638 FEZ1
fasciculation and elongation protein zeta 1 (zygin I) Nicotine results in increased expression of FEZ1 mRNA increases expression
mRNA 12588870
D009538 9638 FEZ1
fasciculation and elongation protein zeta 1 (zygin I) Tubocurarine promotes the reaction [Nicotine results in decreased expression of FEZ1 mRNA] decreases expression
/ increases reaction
mRNA 12588870
D009538 2247 FGF2
BFGF
FGF-2
FGFB
HBGF-2
fibroblast growth factor 2 (basic) Nicotine results in increased secretion of FGF2 protein increases secretion
protein 16365874
D009538 2322 FLT3
CD135
FLK-2
FLK2
STK1
fms-related tyrosine kinase 3 (EC:2.7.10.1) Nicotine results in decreased expression of FLT3 mRNA decreases expression
mRNA 18247414
D009538 2328 FMO3
FMOII
TMAU
dJ127D3.1
flavin containing monooxygenase 3 (EC:1.14.13.8 1.14.13.148) FMO3 protein results in increased metabolism of Nicotine increases metabolic processing
protein 12504349
D009538 2335 FN1
CIG
ED-B
FINC
FN
FNZ
GFND
GFND2
LETS
MSF
fibronectin 1 Nicotine results in decreased expression of FN1 mRNA decreases expression
mRNA 18247414
D009538 2335 FN1
CIG
ED-B
FINC
FN
FNZ
GFND
GFND2
LETS
MSF
fibronectin 1 Nicotine results in increased expression of FN1 protein increases expression
protein 18844224
D009538 2348 FOLR1
FBP
FOLR
folate receptor 1 (adult) Nicotine results in increased expression of FOLR1 mRNA increases expression
mRNA 19616087
D009538 2353 FOS
AP-1
C-FOS
p55
FBJ murine osteosarcoma viral oncogene homolog Nicotine results in increased expression of FOS increases expression
11425648
D009538 2353 FOS
AP-1
C-FOS
p55
FBJ murine osteosarcoma viral oncogene homolog Nicotine results in increased expression of FOS mRNA increases expression
mRNA 17151781
D009538 2353 FOS
AP-1
C-FOS
p55
FBJ murine osteosarcoma viral oncogene homolog Nicotine results in increased expression of FOS protein increases expression
protein 17003101
D009538 2353 FOS
AP-1
C-FOS
p55
FBJ murine osteosarcoma viral oncogene homolog Tubocurarine inhibits the reaction [Nicotine results in increased expression of FOS] decreases reaction
/ increases expression
11425648
D009538 2353 FOS
AP-1
C-FOS
p55
FBJ murine osteosarcoma viral oncogene homolog [U 0126 results in decreased activity of [MAPK1 protein co-treated with MAPK3 protein]] inhibits the reaction [Nicotine results in increased expression of FOS protein] affects cotreatment
/ decreases activity
/ decreases reaction
/ increases expression
protein 17003101
D009538 2354 FOSB
AP-1
G0S3
GOS3
GOSB
FBJ murine osteosarcoma viral oncogene homolog B Nicotine results in increased expression of FOSB mRNA increases expression
mRNA 16949557
D009538 2308 FOXO1
FKH1
FKHR
FOXO1A
forkhead box O1 [Nicotine results in increased phosphorylation of and results in increased activity of AKT1 protein] which results in increased phosphorylation of FOXO1 protein increases activity
/ increases phosphorylation
protein 12511591
D009538 2534 FYN
SLK
SYN
p59-FYN
FYN oncogene related to SRC, FGR, YES (EC:2.7.10.2) LCK protein promotes the reaction [Nicotine results in increased phosphorylation of and results in increased activity of FYN protein] increases activity
/ increases phosphorylation
/ increases reaction
protein 17709503
D009538 2534 FYN
SLK
SYN
p59-FYN
FYN oncogene related to SRC, FGR, YES (EC:2.7.10.2) Nicotine results in increased phosphorylation of and results in increased activity of FYN protein increases activity
/ increases phosphorylation
protein 17709503
D009538 2582 GALE
SDR1E1
UDP-galactose-4-epimerase (EC:5.1.3.2) Nicotine results in decreased expression of GALE mRNA decreases expression
mRNA 16949557
D009538 2624 GATA2
DCML
MONOMAC
NFE1B
GATA binding protein 2 5-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone inhibits the reaction [Nicotine results in increased expression of GATA2 mRNA] decreases reaction
/ increases expression
mRNA 18450646
D009538 2624 GATA2
DCML
MONOMAC
NFE1B
GATA binding protein 2 5-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone inhibits the reaction [Nicotine results in increased expression of GATA2 protein] decreases reaction
/ increases expression
protein 18450646
D009538 2624 GATA2
DCML
MONOMAC
NFE1B
GATA binding protein 2 Bungarotoxins inhibits the reaction [Nicotine results in increased expression of GATA2 mRNA] decreases reaction
/ increases expression
mRNA 18450646
D009538 2624 GATA2
DCML
MONOMAC
NFE1B
GATA binding protein 2 Bungarotoxins inhibits the reaction [Nicotine results in increased expression of GATA2 protein] decreases reaction
/ increases expression
protein 18450646
D009538 2624 GATA2
DCML
MONOMAC
NFE1B
GATA binding protein 2 CHRNA7 protein affects the reaction [Nicotine results in increased expression of GATA2 mRNA] affects reaction
/ increases expression
mRNA 18450646
D009538 2624 GATA2
DCML
MONOMAC
NFE1B
GATA binding protein 2 CHRNA7 protein affects the reaction [Nicotine results in increased expression of GATA2 protein] affects reaction
/ increases expression
protein 18450646
D009538 2624 GATA2
DCML
MONOMAC
NFE1B
GATA binding protein 2 GATA2 protein affects the reaction [Nicotine results in increased expression of CHRNA7 mRNA] affects reaction
/ increases expression
protein 18450646
D009538 2624 GATA2
DCML
MONOMAC
NFE1B
GATA binding protein 2 GATA2 protein affects the reaction [Nicotine results in increased expression of CHRNA7 protein] affects reaction
/ increases expression
protein 18450646
D009538 2624 GATA2
DCML
MONOMAC
NFE1B
GATA binding protein 2 manumycin inhibits the reaction [Nicotine results in increased expression of GATA2 mRNA] decreases reaction
/ increases expression
mRNA 18450646
D009538 2624 GATA2
DCML
MONOMAC
NFE1B
GATA binding protein 2 manumycin inhibits the reaction [Nicotine results in increased expression of GATA2 protein] decreases reaction
/ increases expression
protein 18450646
D009538 2624 GATA2
DCML
MONOMAC
NFE1B
GATA binding protein 2 Nicotine results in increased expression of GATA2 mRNA increases expression
mRNA 18450646
D009538 2624 GATA2
DCML
MONOMAC
NFE1B
GATA binding protein 2 Nicotine results in increased expression of GATA2 protein increases expression
protein 18450646
D009538 2624 GATA2
DCML
MONOMAC
NFE1B
GATA binding protein 2 U 0126 inhibits the reaction [Nicotine results in increased expression of GATA2 mRNA] decreases reaction
/ increases expression
mRNA 18450646
D009538 2624 GATA2
DCML
MONOMAC
NFE1B
GATA binding protein 2 U 0126 inhibits the reaction [Nicotine results in increased expression of GATA2 protein] decreases reaction
/ increases expression
protein 18450646
D009538 2643 GCH1
DYT14
DYT5
DYT5a
GCH
GTP-CH-1
GTPCH1
HPABH4B
GTP cyclohydrolase 1 (EC:3.5.4.16) Nicotine results in increased expression of GCH1 mRNA increases expression
mRNA 16949557
D009538 2657 GDF1
DORV
DTGA3
RAI
growth differentiation factor 1 Nicotine results in increased expression of GDF1 mRNA increases expression
mRNA 18247414
D009538 11010 GLIPR1
CRISP7
GLIPR
RTVP1
GLI pathogenesis-related 1 Nicotine results in increased expression of GLIPR1 mRNA increases expression
mRNA 16949557
D009538 2790 GNG10
guanine nucleotide binding protein (G protein), gamma 10 Nicotine results in increased expression of GNG10 mRNA increases expression
mRNA 16949557
D009538 2803 GOLGA4
GCP2
GOLG
MU-RMS-40.18
p230
golgin A4 alpha-cobratoxin inhibits the reaction [Nicotine results in increased expression of GOLGA4 mRNA] decreases reaction
/ increases expression
mRNA 16949557
D009538 2803 GOLGA4
GCP2
GOLG
MU-RMS-40.18
p230
golgin A4 Nicotine results in increased expression of GOLGA4 mRNA increases expression
mRNA 16949557
D009538 2803 GOLGA4
GCP2
GOLG
MU-RMS-40.18
p230
golgin A4 Tubocurarine inhibits the reaction [Nicotine results in increased expression of GOLGA4 mRNA] decreases reaction
/ increases expression
mRNA 16949557
D009538 2876 GPX1
GPXD
GSHPX1
glutathione peroxidase 1 (EC:1.11.1.9) Nicotine results in decreased expression of GPX1 mRNA decreases expression
mRNA 16949557
D009538 30206 Nicotine results in decreased expression of GRO2 mRNA decreases expression
mRNA 18247414
D009538 2931 GSK3A
glycogen synthase kinase 3 alpha (EC:2.7.11.1 2.7.11.26) [Nicotine results in increased phosphorylation of and results in increased activity of AKT1 protein] which results in increased phosphorylation of GSK3A protein increases activity
/ increases phosphorylation
protein 12511591
D009538 2932 GSK3B
glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26) [Nicotine results in increased phosphorylation of and results in increased activity of AKT1 protein] which results in increased phosphorylation of GSK3B protein increases activity
/ increases phosphorylation
protein 12511591
D009538 2978 GUCA1A
C6orf131
COD3
CORD14
GCAP
GCAP1
GUCA
GUCA1
dJ139D8.6
guanylate cyclase activator 1A (retina) Nicotine results in decreased expression of GUCA1A mRNA decreases expression
mRNA 16949557
D009538 3094 HINT1
HINT
NMAN
PKCI-1
PRKCNH1
histidine triad nucleotide binding protein 1 Nicotine results in increased expression of HINT1 mRNA increases expression
mRNA 20514075
D009538 6596 HLTF
HIP116
HIP116A
HLTF1
RNF80
SMARCA3
SNF2L3
ZBU1
helicase-like transcription factor Nicotine results in decreased expression of HLTF mRNA decreases expression
mRNA 18247414
D009538 3159 HMGA1
HMG-R
HMGA1A
HMGIY
high mobility group AT-hook 1 Nicotine results in decreased expression of HMGA1 mRNA decreases expression
mRNA 16949557
D009538 3156 HMGCR
LDLCQ3
3-hydroxy-3-methylglutaryl-CoA reductase (EC:1.1.1.34) Nicotine results in increased expression of HMGCR mRNA increases expression
mRNA 23416264
D009538 50809 HP1BP3
HP1-BP74
heterochromatin protein 1, binding protein 3 Nicotine results in increased expression of HP1BP3 mRNA increases expression
mRNA 16949557
D009538 3320 HSP90AA1
EL52
HSP86
HSP89A
HSP90A
HSP90N
HSPC1
HSPCA
HSPCAL1
HSPCAL4
HSPN
Hsp89
Hsp90
LAP2
heat shock protein 90kDa alpha (cytosolic), class A member 1 Nicotine results in increased expression of HSP90AA1 mRNA increases expression
mRNA 12115584
D009538 3320 HSP90AA1
EL52
HSP86
HSP89A
HSP90A
HSP90N
HSPC1
HSPCA
HSPCAL1
HSPCAL4
HSPN
Hsp89
Hsp90
LAP2
heat shock protein 90kDa alpha (cytosolic), class A member 1 Nicotine results in increased expression of HSP90AA1 protein increases expression
protein 12115584
D009538 3422 IDI1
IPP1
IPPI1
isopentenyl-diphosphate delta isomerase 1 (EC:5.3.3.2) Nicotine results in increased expression of IDI1 mRNA increases expression
mRNA 16949557
D009538 2537 IFI6
6-16
FAM14C
G1P3
IFI-6-16
IFI616
interferon, alpha-inducible protein 6 Nicotine results in decreased expression of IFI6 mRNA decreases expression
mRNA 18247414
D009538 3454 IFNAR1
AVP
IFN-alpha-REC
IFNAR
IFNBR
IFRC
interferon (alpha, beta and omega) receptor 1 Nicotine results in decreased expression of IFNAR1 mRNA decreases expression
mRNA 18247414
D009538 3507 Nicotine results in decreased expression of IGHM mRNA decreases expression
mRNA 18247414
D009538 3586 IL10
CSIF
GVHDS
IL-10
IL10A
TGIF
interleukin 10 Nicotine results in decreased expression of IL10 mRNA decreases expression
mRNA 18247414
D009538 3552 IL1A
IL-1A
IL1
IL1-ALPHA
IL1F1
interleukin 1, alpha Nicotine results in increased expression of and results in increased secretion of IL1A protein increases expression
/ increases secretion
protein 18082304
D009538 3553 IL1B
IL-1
IL1-BETA
IL1F2
interleukin 1, beta 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Nicotine promotes the reaction [IL1B protein results in increased expression of IL8 protein]] decreases reaction
/ increases expression
/ increases reaction
protein 22119045
D009538 3553 IL1B
IL-1
IL1-BETA
IL1F2
interleukin 1, beta Nicotine promotes the reaction [IL1B protein results in increased expression of IL8 mRNA] increases expression
/ increases reaction
protein 22119045
D009538 3553 IL1B
IL-1
IL1-BETA
IL1F2
interleukin 1, beta Nicotine promotes the reaction [IL1B protein results in increased expression of IL8 protein] increases expression
/ increases reaction
protein 22119045
D009538 3553 IL1B
IL-1
IL1-BETA
IL1F2
interleukin 1, beta Nicotine promotes the reaction [IL1B protein results in increased secretion of IL8 protein] increases reaction
/ increases secretion
protein 22119045
D009538 3553 IL1B
IL-1
IL1-BETA
IL1F2
interleukin 1, beta Nicotine results in increased expression of and results in increased secretion of IL1B protein increases expression
/ increases secretion
protein 18082304
D009538 3553 IL1B
IL-1
IL1-BETA
IL1F2
interleukin 1, beta Tubocurarine inhibits the reaction [Nicotine promotes the reaction [IL1B protein results in increased expression of IL8 mRNA]] decreases reaction
/ increases expression
/ increases reaction
protein 22119045
D009538 3553 IL1B
IL-1
IL1-BETA
IL1F2
interleukin 1, beta Tubocurarine inhibits the reaction [Nicotine promotes the reaction [IL1B protein results in increased secretion of IL8 protein]] decreases reaction
/ increases reaction
/ increases secretion
protein 22119045
D009538 3553 IL1B
IL-1
IL1-BETA
IL1F2
interleukin 1, beta U 0126 inhibits the reaction [Nicotine promotes the reaction [IL1B protein results in increased expression of IL8 protein]] decreases reaction
/ increases expression
/ increases reaction
protein 22119045
D009538 3558 IL2
IL-2
TCGF
lymphokine
interleukin 2 Nicotine results in decreased susceptibility to IL2 protein decreases response to substance
protein 15231866
D009538 3563 IL3RA
CD123
IL3R
IL3RAY
IL3RX
IL3RY
hIL-3Ra
interleukin 3 receptor, alpha (low affinity) Nicotine results in decreased expression of IL3RA mRNA decreases expression
mRNA 18247414
D009538 3569 IL6
BSF2
HGF
HSF
IFNB2
IL-6
interleukin 6 (interferon, beta 2) Nicotine results in increased expression of and results in increased secretion of IL6 protein increases expression
/ increases secretion
protein 18082304
D009538 3574 IL7
IL-7
interleukin 7 Nicotine results in increased expression of and results in increased secretion of IL7 protein increases expression
/ increases secretion
protein 18082304
D009538 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Nicotine promotes the reaction [IL1B protein results in increased expression of IL8 protein]] decreases reaction
/ increases expression
/ increases reaction
protein 22119045
D009538 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 Nicotine promotes the reaction [IL1B protein results in increased expression of IL8 mRNA] increases expression
/ increases reaction
mRNA 22119045
D009538 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 Nicotine promotes the reaction [IL1B protein results in increased expression of IL8 protein] increases expression
/ increases reaction
protein 22119045
D009538 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 Nicotine promotes the reaction [IL1B protein results in increased secretion of IL8 protein] increases reaction
/ increases secretion
protein 22119045
D009538 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 Nicotine promotes the reaction [Lipopolysaccharides results in increased expression of IL8 mRNA] increases expression
/ increases reaction
mRNA 22119045
D009538 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 Nicotine results in increased expression of IL8 mRNA increases expression
mRNA 22119045
D009538 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 Tubocurarine inhibits the reaction [Nicotine promotes the reaction [IL1B protein results in increased expression of IL8 mRNA]] decreases reaction
/ increases expression
/ increases reaction
mRNA 22119045
D009538 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 Tubocurarine inhibits the reaction [Nicotine promotes the reaction [IL1B protein results in increased secretion of IL8 protein]] decreases reaction
/ increases reaction
/ increases secretion
protein 22119045
D009538 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 U 0126 inhibits the reaction [Nicotine promotes the reaction [IL1B protein results in increased expression of IL8 protein]] decreases reaction
/ increases expression
/ increases reaction
protein 22119045
D009538 3578 IL9
HP40
IL-9
P40
interleukin 9 Nicotine results in decreased expression of IL9 mRNA decreases expression
mRNA 18247414
D009538 3638 INSIG1
CL-6
CL6
insulin induced gene 1 Nicotine results in increased expression of INSIG1 mRNA increases expression
mRNA 23416264
D009538 3674 ITGA2B
BDPLT16
BDPLT2
CD41
CD41B
GP2B
GPIIb
GT
GTA
HPA3
integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) Nicotine results in decreased expression of ITGA2B mRNA decreases expression
mRNA 21385097
D009538 3674 ITGA2B
BDPLT16
BDPLT2
CD41
CD41B
GP2B
GPIIb
GT
GTA
HPA3
integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) Nicotine results in decreased expression of ITGA2B protein decreases expression
protein 21385097
D009538 3683 ITGAL
CD11A
LFA-1
LFA1A
integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) Nicotine results in decreased expression of ITGAL mRNA decreases expression
mRNA 18247414
D009538 3688 ITGB1
CD29
FNRB
GPIIA
MDF2
MSK12
VLA-BETA
VLAB
integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) Nicotine results in decreased expression of ITGB1 protein decreases expression
protein 11338295
D009538 3690 ITGB3
BDPLT16
BDPLT2
CD61
GP3A
GPIIIa
GT
integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) Nicotine results in decreased expression of ITGB3 mRNA decreases expression
mRNA 21385097
D009538 3690 ITGB3
BDPLT16
BDPLT2
CD61
GP3A
GPIIIa
GT
integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) Nicotine results in decreased expression of ITGB3 protein decreases expression
protein 21385097
D009538 3713 IVL
involucrin Nicotine results in decreased expression of IVL protein decreases expression
protein 16011614
D009538 80853 KDM7A
JHDM1D
lysine (K)-specific demethylase 7A Nicotine results in increased expression of JHDM1D mRNA increases expression
mRNA 16949557
D009538 3725 JUN
AP-1
AP1
c-Jun
jun proto-oncogene Nicotine inhibits the reaction [Cisplatin results in increased expression of JUN mRNA] decreases reaction
/ increases expression
mRNA 11592233
D009538 3725 JUN
AP-1
AP1
c-Jun
jun proto-oncogene Nicotine results in increased expression of JUN protein increases expression
protein 17003101
D009538 3725 JUN
AP-1
AP1
c-Jun
jun proto-oncogene [U 0126 results in decreased activity of [MAPK1 protein co-treated with MAPK3 protein]] inhibits the reaction [Nicotine results in increased expression of JUN protein] affects cotreatment
/ decreases activity
/ decreases reaction
/ increases expression
protein 17003101
D009538 3726 JUNB
AP-1
jun B proto-oncogene Nicotine results in increased expression of JUNB mRNA increases expression
mRNA 18805435
D009538 8462 KLF11
FKLF
FKLF1
MODY7
TIEG2
Tieg3
Kruppel-like factor 11 Nicotine results in decreased expression of KLF11 mRNA decreases expression
mRNA 18247414
D009538 58508 KMT2C
HALR
MLL3
lysine (K)-specific methyltransferase 2C (EC:2.1.1.43) alpha-cobratoxin inhibits the reaction [Nicotine results in decreased expression of KMT2C mRNA] decreases expression
/ decreases reaction
mRNA 12588870
D009538 58508 KMT2C
HALR
MLL3
lysine (K)-specific methyltransferase 2C (EC:2.1.1.43) Mecamylamine inhibits the reaction [Nicotine results in decreased expression of KMT2C mRNA] decreases expression
/ decreases reaction
mRNA 12588870
D009538 58508 KMT2C
HALR
MLL3
lysine (K)-specific methyltransferase 2C (EC:2.1.1.43) Nicotine results in decreased expression of KMT2C mRNA decreases expression
mRNA 12588870
D009538 58508 KMT2C
HALR
MLL3
lysine (K)-specific methyltransferase 2C (EC:2.1.1.43) Tubocurarine inhibits the reaction [Nicotine results in decreased expression of KMT2C mRNA] decreases expression
/ decreases reaction
mRNA 12588870
D009538 3912 LAMB1
CLM
LIS5
laminin, beta 1 Nicotine results in increased expression of LAMB1 mRNA increases expression
mRNA 16949557
D009538 3932 LCK
LSK
YT16
p56lck
pp58lck
lymphocyte-specific protein tyrosine kinase (EC:2.7.10.2) LCK protein promotes the reaction [Nicotine results in increased phosphorylation of and results in increased activity of FYN protein] increases activity
/ increases phosphorylation
/ increases reaction
protein 17709503
D009538 3932 LCK
LSK
YT16
p56lck
pp58lck
lymphocyte-specific protein tyrosine kinase (EC:2.7.10.2) Nicotine results in increased phosphorylation of and results in increased activity of LCK protein increases activity
/ increases phosphorylation
protein 17709503
D009538 3936 LCP1
CP64
L-PLASTIN
LC64P
LPL
PLS2
lymphocyte cytosolic protein 1 (L-plastin) LCP1 gene SNP affects the susceptibility to Nicotine affects response to substance
gene 18438686
D009538 3949 LDLR
FH
FHC
LDLCQ2
low density lipoprotein receptor Nicotine results in increased expression of LDLR mRNA increases expression
mRNA 23416264
D009538 3981 LIG4
ligase IV, DNA, ATP-dependent (EC:6.5.1.1) Nicotine results in increased expression of LIG4 mRNA increases expression
mRNA 16949557
D009538 9516 LITAF
PIG7
SIMPLE
TP53I7
lipopolysaccharide-induced TNF factor alpha-cobratoxin inhibits the reaction [Nicotine results in decreased expression of LITAF mRNA] decreases expression
/ decreases reaction
mRNA 12588870
D009538 9516 LITAF
PIG7
SIMPLE
TP53I7
lipopolysaccharide-induced TNF factor Mecamylamine promotes the reaction [Nicotine results in decreased expression of LITAF mRNA] decreases expression
/ increases reaction
mRNA 12588870
D009538 9516 LITAF
PIG7
SIMPLE
TP53I7
lipopolysaccharide-induced TNF factor Nicotine results in decreased expression of LITAF mRNA decreases expression
mRNA 12588870
D009538 9516 LITAF
PIG7
SIMPLE
TP53I7
lipopolysaccharide-induced TNF factor Tubocurarine inhibits the reaction [Nicotine results in decreased expression of LITAF mRNA] decreases expression
/ decreases reaction
mRNA 12588870
D009538 9208 LRRFIP1
FLAP-1
FLAP1
FLIIAP1
GCF-2
GCF2
HUFI-1
TRIP
leucine rich repeat (in FLII) interacting protein 1 Nicotine results in increased expression of LRRFIP1 mRNA increases expression
mRNA 16949557
D009538 4050 LTB
TNFC
TNFSF3
p33
lymphotoxin beta (TNF superfamily, member 3) Nicotine results in decreased expression of LTB mRNA decreases expression
mRNA 18247414
D009538 116068 LYSMD3
LysM, putative peptidoglycan-binding, domain containing 3 LYSMD3 gene SNP affects the susceptibility to Nicotine affects response to substance
gene 18438686
D009538 8567 MADD
DENN
IG20
RAB3GEP
MAP-kinase activating death domain Nicotine results in decreased expression of MADD mRNA decreases expression
mRNA 18247414
D009538 378938 MALAT1
HCN
LINC00047
MALAT-1
NCRNA00047
NEAT2
PRO2853
metastasis associated lung adenocarcinoma transcript 1 (non-protein coding) Nicotine results in increased expression of MALAT1 mRNA increases expression
mRNA 16949557
D009538 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein] decreases reaction
/ increases phosphorylation
protein 22119045
D009538 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [Nicotine results in decreased activity of MAPK1 protein] decreases activity
/ decreases reaction
protein 20106947
D009538 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) [Atenolol binds to and results in decreased activity of ADRB1 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein] affects binding
/ decreases activity
/ decreases reaction
/ increases phosphorylation
protein 17003101
D009538 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) Curcumin inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein] decreases reaction
/ increases phosphorylation
protein 20727180
D009538 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) Hexamethonium inhibits the reaction [Nicotine results in decreased phosphorylation of MAPK1 protein] decreases phosphorylation
/ decreases reaction
protein 20106947
D009538 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) Hexamethonium inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein] decreases reaction
/ increases phosphorylation
protein 18448488
D009538 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) [ICI 118551 binds to and results in decreased activity of ADRB2 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein] affects binding
/ decreases activity
/ decreases reaction
/ increases phosphorylation
protein 17003101
D009538 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) [Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein] affects binding
/ decreases activity
/ decreases reaction
/ increases phosphorylation
protein 18448488
D009538 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) Lobeline inhibits the reaction [Nicotine results in decreased phosphorylation of MAPK1 protein] decreases phosphorylation
/ decreases reaction
protein 20106947
D009538 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein] affects binding
/ decreases activity
/ decreases reaction
/ increases phosphorylation
protein 18448488
D009538 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) Nicotine inhibits the reaction [Cisplatin results in increased activity of MAPK1 protein] decreases reaction
/ increases activity
protein 20106947
D009538 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) Nicotine inhibits the reaction [Paclitaxel results in increased activity of MAPK1 protein] decreases reaction
/ increases activity
protein 20106947
D009538 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) Nicotine results in decreased phosphorylation of and results in decreased activity of MAPK1 protein decreases activity
/ decreases phosphorylation
protein 20106947
D009538 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) Nicotine results in increased activity of MAPK1 protein increases activity
protein 12421819
17459420
D009538 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) Nicotine results in increased expression of MAPK1 protein modified form increases expression
protein 18676776
D009538 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) Nicotine results in increased phosphorylation of and results in increased activity of MAPK1 protein increases activity
/ increases phosphorylation
protein 19903766
D009538 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) Nicotine results in increased phosphorylation of MAPK1 protein increases phosphorylation
protein 17003101
18448488
20727180
22119045
22261521
D009538 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) Propranolol inhibits the reaction [Nicotine results in decreased phosphorylation of MAPK1 protein] decreases phosphorylation
/ decreases reaction
protein 20106947
D009538 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) Propranolol inhibits the reaction [Nicotine results in increased phosphorylation of and results in increased activity of MAPK1 protein] decreases reaction
/ increases activity
/ increases phosphorylation
protein 19903766
D009538 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) Propranolol inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein] decreases reaction
/ increases phosphorylation
protein 18448488
D009538 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) Staurosporine inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein] decreases reaction
/ increases phosphorylation
protein 17003101
D009538 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) TP53 protein affects the reaction [Nicotine results in increased phosphorylation of MAPK1 protein] affects reaction
/ increases phosphorylation
protein 20727180
D009538 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) Tubocurarine inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein] decreases reaction
/ increases phosphorylation
protein 22119045
D009538 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) U 0126 inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein] decreases reaction
/ increases phosphorylation
protein 17003101
D009538 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) [U 0126 results in decreased activity of [MAPK1 protein co-treated with MAPK3 protein]] inhibits the reaction [Nicotine results in increased expression of FOS protein] affects cotreatment
/ decreases activity
/ decreases reaction
/ increases expression
protein 17003101
D009538 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) [U 0126 results in decreased activity of [MAPK1 protein co-treated with MAPK3 protein]] inhibits the reaction [Nicotine results in increased expression of JUN protein] affects cotreatment
/ decreases activity
/ decreases reaction
/ increases expression
protein 17003101
D009538 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) [U 0126 results in decreased activity of [MAPK1 protein co-treated with MAPK3 protein]] inhibits the reaction [Nicotine results in increased expression of PTGS2] affects cotreatment
/ decreases activity
/ decreases reaction
/ increases expression
protein 17003101
D009538 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) [U 0126 results in decreased activity of [MAPK1 protein co-treated with MAPK3 protein]] which results in decreased susceptibility to Nicotine affects cotreatment
/ decreases activity
/ decreases response to substance
protein 17003101
D009538 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein] decreases reaction
/ increases phosphorylation
protein 22119045
D009538 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [Nicotine results in decreased activity of MAPK3 protein] decreases activity
/ decreases reaction
protein 20106947
D009538 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) [Atenolol binds to and results in decreased activity of ADRB1 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein] affects binding
/ decreases activity
/ decreases reaction
/ increases phosphorylation
protein 17003101
D009538 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) Curcumin inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein] decreases reaction
/ increases phosphorylation
protein 20727180
D009538 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) Hexamethonium inhibits the reaction [Nicotine results in decreased phosphorylation of MAPK3 protein] decreases phosphorylation
/ decreases reaction
protein 20106947
D009538 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) Hexamethonium inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein] decreases reaction
/ increases phosphorylation
protein 18448488
D009538 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) [ICI 118551 binds to and results in decreased activity of ADRB2 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein] affects binding
/ decreases activity
/ decreases reaction
/ increases phosphorylation
protein 17003101
D009538 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) [Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein] affects binding
/ decreases activity
/ decreases reaction
/ increases phosphorylation
protein 18448488
D009538 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) Lobeline inhibits the reaction [Nicotine results in decreased phosphorylation of MAPK3 protein] decreases phosphorylation
/ decreases reaction
protein 20106947
D009538 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein] affects binding
/ decreases activity
/ decreases reaction
/ increases phosphorylation
protein 18448488
D009538 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) Nicotine inhibits the reaction [Cisplatin results in increased activity of MAPK3 protein] decreases reaction
/ increases activity
protein 20106947
D009538 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) Nicotine inhibits the reaction [Paclitaxel results in increased activity of MAPK3 protein] decreases reaction
/ increases activity
protein 20106947
D009538 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) Nicotine results in decreased activity of MAPK3 protein decreases activity
protein 20106947
D009538 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) Nicotine results in decreased phosphorylation of and results in decreased activity of MAPK3 protein decreases activity
/ decreases phosphorylation
protein 20106947
D009538 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) Nicotine results in increased activity of MAPK3 protein increases activity
protein 12421819
17459420
D009538 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) Nicotine results in increased expression of MAPK3 protein modified form increases expression
protein 18676776
D009538 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) Nicotine results in increased phosphorylation of and results in increased activity of MAPK3 protein increases activity
/ increases phosphorylation
protein 19903766
D009538 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) Nicotine results in increased phosphorylation of MAPK3 protein increases phosphorylation
protein 17003101
18448488
20727180
22119045
22261521
D009538 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) Propranolol inhibits the reaction [Nicotine results in decreased phosphorylation of MAPK3 protein] decreases phosphorylation
/ decreases reaction
protein 20106947
D009538 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) Propranolol inhibits the reaction [Nicotine results in increased phosphorylation of and results in increased activity of MAPK3 protein] decreases reaction
/ increases activity
/ increases phosphorylation
protein 19903766
D009538 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) Propranolol inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein] decreases reaction
/ increases phosphorylation
protein 18448488
D009538 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) Staurosporine inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein] decreases reaction
/ increases phosphorylation
protein 17003101
D009538 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) TP53 protein affects the reaction [Nicotine results in increased phosphorylation of MAPK3 protein] affects reaction
/ increases phosphorylation
protein 20727180
D009538 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) Tubocurarine inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein] decreases reaction
/ increases phosphorylation
protein 22119045
D009538 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) U 0126 inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein] decreases reaction
/ increases phosphorylation
protein 17003101
D009538 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) [U 0126 results in decreased activity of [MAPK1 protein co-treated with MAPK3 protein]] inhibits the reaction [Nicotine results in increased expression of FOS protein] affects cotreatment
/ decreases activity
/ decreases reaction
/ increases expression
protein 17003101
D009538 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) [U 0126 results in decreased activity of [MAPK1 protein co-treated with MAPK3 protein]] inhibits the reaction [Nicotine results in increased expression of JUN protein] affects cotreatment
/ decreases activity
/ decreases reaction
/ increases expression
protein 17003101
D009538 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) [U 0126 results in decreased activity of [MAPK1 protein co-treated with MAPK3 protein]] inhibits the reaction [Nicotine results in increased expression of PTGS2] affects cotreatment
/ decreases activity
/ decreases reaction
/ increases expression
protein 17003101
D009538 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) [U 0126 results in decreased activity of [MAPK1 protein co-treated with MAPK3 protein]] which results in decreased susceptibility to Nicotine affects cotreatment
/ decreases activity
/ decreases response to substance
protein 17003101
D009538 5599 MAPK8
JNK
JNK-46
JNK1
JNK1A2
JNK21B1/2
PRKM8
SAPK1
SAPK1c
mitogen-activated protein kinase 8 (EC:2.7.11.24) Curcumin inhibits the reaction [Nicotine results in increased phosphorylation of MAPK8 protein] decreases reaction
/ increases phosphorylation
protein 20727180
D009538 5599 MAPK8
JNK
JNK-46
JNK1
JNK1A2
JNK21B1/2
PRKM8
SAPK1
SAPK1c
mitogen-activated protein kinase 8 (EC:2.7.11.24) Nicotine inhibits the reaction [Cisplatin results in increased phosphorylation of and results in increased activity of MAPK8 protein] decreases reaction
/ increases activity
/ increases phosphorylation
protein 11592233
D009538 5599 MAPK8
JNK
JNK-46
JNK1
JNK1A2
JNK21B1/2
PRKM8
SAPK1
SAPK1c
mitogen-activated protein kinase 8 (EC:2.7.11.24) Nicotine results in increased phosphorylation of MAPK8 protein increases phosphorylation
protein 20727180
D009538 5599 MAPK8
JNK
JNK-46
JNK1
JNK1A2
JNK21B1/2
PRKM8
SAPK1
SAPK1c
mitogen-activated protein kinase 8 (EC:2.7.11.24) TP53 protein affects the reaction [Nicotine results in increased phosphorylation of MAPK8 protein] affects reaction
/ increases phosphorylation
protein 20727180
D009538 4170 MCL1
BCL2L3
EAT
MCL1-ES
MCL1L
MCL1S
Mcl-1
TM
bcl2-L-3
mcl1/EAT
myeloid cell leukemia sequence 1 (BCL2-related) 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Nicotine results in increased phosphorylation of MCL1 protein] decreases reaction
/ increases phosphorylation
protein 19903766
D009538 4170 MCL1
BCL2L3
EAT
MCL1-ES
MCL1L
MCL1S
Mcl-1
TM
bcl2-L-3
mcl1/EAT
myeloid cell leukemia sequence 1 (BCL2-related) Nicotine results in increased phosphorylation of MCL1 protein increases phosphorylation
protein 19903766
D009538 4170 MCL1
BCL2L3
EAT
MCL1-ES
MCL1L
MCL1S
Mcl-1
TM
bcl2-L-3
mcl1/EAT
myeloid cell leukemia sequence 1 (BCL2-related) [Nicotine results in increased phosphorylation of MCL1 protein] which results in increased expression of and results in increased stability of MCL1 protein increases expression
/ increases phosphorylation
/ increases stability
protein 19903766
D009538 4170 MCL1
BCL2L3
EAT
MCL1-ES
MCL1L
MCL1S
Mcl-1
TM
bcl2-L-3
mcl1/EAT
myeloid cell leukemia sequence 1 (BCL2-related) Propranolol inhibits the reaction [Nicotine results in increased phosphorylation of MCL1 protein] decreases reaction
/ increases phosphorylation
protein 19903766
D009538 80306 MED28
1500003D12Rik
EG1
magicin
mediator complex subunit 28 Nicotine results in increased expression of MED28 mRNA increases expression
mRNA 16949557
D009538 4312 MMP1
CLG
CLGN
matrix metallopeptidase 1 (interstitial collagenase) (EC:3.4.24.7) lipopolysaccharide, E. coli 026-B6 promotes the reaction [Nicotine results in increased expression of MMP1 mRNA] increases expression
/ increases reaction
mRNA 18986645
D009538 4312 MMP1
CLG
CLGN
matrix metallopeptidase 1 (interstitial collagenase) (EC:3.4.24.7) lipopolysaccharide, E. coli 026-B6 promotes the reaction [Nicotine results in increased expression of MMP1 protein] increases expression
/ increases reaction
protein 18986645
D009538 4312 MMP1
CLG
CLGN
matrix metallopeptidase 1 (interstitial collagenase) (EC:3.4.24.7) Nicotine promotes the reaction [lipopolysaccharide, E. coli 026-B6 results in increased expression of MMP1 mRNA] increases expression
/ increases reaction
mRNA 18986645
D009538 4312 MMP1
CLG
CLGN
matrix metallopeptidase 1 (interstitial collagenase) (EC:3.4.24.7) Nicotine promotes the reaction [lipopolysaccharide, E. coli 026-B6 results in increased expression of MMP1 protein] increases expression
/ increases reaction
protein 18986645
D009538 4312 MMP1
CLG
CLGN
matrix metallopeptidase 1 (interstitial collagenase) (EC:3.4.24.7) Nicotine results in increased expression of MMP1 mRNA increases expression
mRNA 17151781
18986645
D009538 4312 MMP1
CLG
CLGN
matrix metallopeptidase 1 (interstitial collagenase) (EC:3.4.24.7) Nicotine results in increased expression of MMP1 protein increases expression
protein 17151781
18986645
D009538 4312 MMP1
CLG
CLGN
matrix metallopeptidase 1 (interstitial collagenase) (EC:3.4.24.7) Polymyxin B inhibits the reaction [lipopolysaccharide, E. coli 026-B6 promotes the reaction [Nicotine results in increased expression of MMP1 protein]] decreases reaction
/ increases expression
/ increases reaction
protein 18986645
D009538 4312 MMP1
CLG
CLGN
matrix metallopeptidase 1 (interstitial collagenase) (EC:3.4.24.7) Polymyxin B inhibits the reaction [Nicotine promotes the reaction [lipopolysaccharide, E. coli 026-B6 results in increased expression of MMP1 protein]] decreases reaction
/ increases expression
/ increases reaction
protein 18986645
D009538 4312 MMP1
CLG
CLGN
matrix metallopeptidase 1 (interstitial collagenase) (EC:3.4.24.7) Tubocurarine inhibits the reaction [lipopolysaccharide, E. coli 026-B6 promotes the reaction [Nicotine results in increased expression of MMP1 protein]] decreases reaction
/ increases expression
/ increases reaction
protein 18986645
D009538 4312 MMP1
CLG
CLGN
matrix metallopeptidase 1 (interstitial collagenase) (EC:3.4.24.7) Tubocurarine inhibits the reaction [Nicotine promotes the reaction [lipopolysaccharide, E. coli 026-B6 results in increased expression of MMP1 protein]] decreases reaction
/ increases expression
/ increases reaction
protein 18986645
D009538 4312 MMP1
CLG
CLGN
matrix metallopeptidase 1 (interstitial collagenase) (EC:3.4.24.7) Tubocurarine inhibits the reaction [Nicotine results in increased expression of MMP1 mRNA] decreases reaction
/ increases expression
mRNA 17151781
D009538 4312 MMP1
CLG
CLGN
matrix metallopeptidase 1 (interstitial collagenase) (EC:3.4.24.7) Tubocurarine inhibits the reaction [Nicotine results in increased expression of MMP1 protein] decreases reaction
/ increases expression
protein 18986645
D009538 4322 MMP13
CLG3
MANDP1
matrix metallopeptidase 13 (collagenase 3) (EC:3.4.24.-) Nicotine results in increased expression of MMP13 mRNA increases expression
mRNA 17151781
D009538 4322 MMP13
CLG3
MANDP1
matrix metallopeptidase 13 (collagenase 3) (EC:3.4.24.-) Nicotine results in increased expression of MMP13 protein increases expression
protein 17151781
D009538 4313 MMP2
CLG4
CLG4A
MMP-II
MONA
TBE-1
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24) lipopolysaccharide, E. coli 026-B6 promotes the reaction [Nicotine results in increased expression of MMP2 mRNA] increases expression
/ increases reaction
mRNA 18986645
D009538 4313 MMP2
CLG4
CLG4A
MMP-II
MONA
TBE-1
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24) Nicotine promotes the reaction [lipopolysaccharide, E. coli 026-B6 results in increased expression of MMP2 mRNA] increases expression
/ increases reaction
mRNA 18986645
D009538 4313 MMP2
CLG4
CLG4A
MMP-II
MONA
TBE-1
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24) Nicotine results in increased expression of MMP2 mRNA increases expression
mRNA 17151781
18986645
D009538 4313 MMP2
CLG4
CLG4A
MMP-II
MONA
TBE-1
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24) Nicotine results in increased expression of MMP2 protein increases expression
protein 14569062
17151781
D009538 4314 MMP3
CHDS6
MMP-3
SL-1
STMY
STMY1
STR1
matrix metallopeptidase 3 (stromelysin 1, progelatinase) (EC:3.4.24.17) lipopolysaccharide, E. coli 026-B6 promotes the reaction [Nicotine results in increased expression of MMP3 mRNA] increases expression
/ increases reaction
mRNA 18986645
D009538 4314 MMP3
CHDS6
MMP-3
SL-1
STMY
STMY1
STR1
matrix metallopeptidase 3 (stromelysin 1, progelatinase) (EC:3.4.24.17) Nicotine promotes the reaction [lipopolysaccharide, E. coli 026-B6 results in increased expression of MMP3 mRNA] increases expression
/ increases reaction
mRNA 18986645
D009538 4314 MMP3
CHDS6
MMP-3
SL-1
STMY
STMY1
STR1
matrix metallopeptidase 3 (stromelysin 1, progelatinase) (EC:3.4.24.17) Nicotine results in increased expression of MMP3 mRNA increases expression
mRNA 17151781
18986645
D009538 4314 MMP3
CHDS6
MMP-3
SL-1
STMY
STMY1
STR1
matrix metallopeptidase 3 (stromelysin 1, progelatinase) (EC:3.4.24.17) Nicotine results in increased expression of MMP3 protein increases expression
protein 17151781
D009538 4316 MMP7
MMP-7
MPSL1
PUMP-1
matrix metallopeptidase 7 (matrilysin, uterine) (EC:3.4.24.23) L 663536 inhibits the reaction [Nicotine results in increased expression of MMP7 mRNA] decreases reaction
/ increases expression
mRNA 20061081
D009538 4316 MMP7
MMP-7
MPSL1
PUMP-1
matrix metallopeptidase 7 (matrilysin, uterine) (EC:3.4.24.23) Nicotine results in increased expression of MMP7 mRNA increases expression
mRNA 20061081
D009538 4318 MMP9
CLG4B
GELB
MANDP2
MMP-9
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) L 663536 inhibits the reaction [Nicotine results in increased expression of MMP9 mRNA] decreases reaction
/ increases expression
mRNA 20061081
D009538 4318 MMP9
CLG4B
GELB
MANDP2
MMP-9
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) Nicotine results in increased expression of MMP9 mRNA increases expression
mRNA 20061081
D009538 4318 MMP9
CLG4B
GELB
MANDP2
MMP-9
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) Nicotine results in increased expression of MMP9 protein increases expression
protein 14569062
D009538 4485 MST1
D3F15S2
DNF15S2
HGFL
MSP
NF15S2
macrophage stimulating 1 (hepatocyte growth factor-like) Nicotine results in decreased expression of MST1 mRNA decreases expression
mRNA 18247414
D009538 4528 MTIF2
mitochondrial translational initiation factor 2 Nicotine results in increased expression of MTIF2 mRNA increases expression
mRNA 16949557
D009538 4605 MYBL2
B-MYB
BMYB
v-myb avian myeloblastosis viral oncogene homolog-like 2 Nicotine results in decreased expression of MYBL2 mRNA decreases expression
mRNA 16949557
D009538 4609 MYC
MRTL
MYCC
bHLHe39
c-Myc
v-myc avian myelocytomatosis viral oncogene homolog Nicotine results in increased activity of MYC protein increases activity
protein 17459420
D009538 4637 MYL6
ESMLC
LC17
LC17-GI
LC17-NM
LC17A
LC17B
MLC-3
MLC1SM
MLC3NM
MLC3SM
myosin, light chain 6, alkali, smooth muscle and non-muscle Nicotine results in decreased expression of MYL6 mRNA decreases expression
mRNA 16949557
D009538 79923 NANOG
Nanog homeobox Nicotine results in increased expression of NANOG mRNA increases expression
mRNA 23219715
D009538 79923 NANOG
Nanog homeobox Nicotine results in increased expression of NANOG protein increases expression
protein 23219715
D009538 79923 NANOG
Nanog homeobox SNAI1 mutant form inhibits the reaction [Nicotine results in increased expression of NANOG mRNA] decreases reaction
/ increases expression
mRNA 23219715
D009538 4698 NDUFA5
B13
CI-13KD-B
CI-13kB
NUFM
UQOR13
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5 (EC:1.6.5.3 1.6.99.3) Nicotine results in increased expression of NDUFA5 mRNA increases expression
mRNA 16949557
D009538 4741 NEFM
NEF3
NF-M
NFM
neurofilament, medium polypeptide Nicotine results in increased expression of NEFM protein increases expression
protein 20457658
D009538 4773 NFATC2
NFAT1
NFATP
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 Nicotine promotes the reaction [NFATC2 protein results in decreased expression of CDK4 protein] decreases expression
/ increases reaction
protein 15231866
D009538 4790 NFKB1
EBP-1
KBF1
NF-kB1
NF-kappa-B
NF-kappaB
NFKB-p105
NFKB-p50
NFkappaB
p105
p50
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 Nicotine results in increased activity of NFKB1 protein increases activity
protein 16598845
D009538 4790 NFKB1
EBP-1
KBF1
NF-kB1
NF-kappa-B
NF-kappaB
NFKB-p105
NFKB-p50
NFkappaB
p105
p50
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 Nicotine results in increased expression of NFKB1 mRNA increases expression
mRNA 16598845
D009538 4790 NFKB1
EBP-1
KBF1
NF-kB1
NF-kappa-B
NF-kappaB
NFKB-p105
NFKB-p50
NFkappaB
p105
p50
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 Vitamin K 3 inhibits the reaction [Nicotine results in increased activity of NFKB1 protein] decreases reaction
/ increases activity
protein 16598845
D009538 4794 NFKBIE
IKBE
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon Nicotine results in decreased expression of NFKBIE mRNA decreases expression
mRNA 18247414
D009538 4801 NFYB
CBF-A
CBF-B
HAP3
NF-YB
nuclear transcription factor Y, beta Nicotine results in decreased expression of NFYB mRNA decreases expression
mRNA 18247414
D009538 51199 NIN
SCKL7
ninein (GSK3B interacting protein) alpha-cobratoxin inhibits the reaction [Nicotine results in increased expression of NIN mRNA] decreases reaction
/ increases expression
mRNA 16949557
D009538 51199 NIN
SCKL7
ninein (GSK3B interacting protein) Nicotine results in increased expression of NIN mRNA increases expression
mRNA 16949557
D009538 51199 NIN
SCKL7
ninein (GSK3B interacting protein) Tubocurarine inhibits the reaction [Nicotine results in increased expression of NIN mRNA] decreases reaction
/ increases expression
mRNA 16949557
D009538 4832 NME3
DR-nm23
NDPK-C
NDPKC
NM23-H3
NM23H3
c371H6.2
NME/NM23 nucleoside diphosphate kinase 3 (EC:2.7.4.6) Nicotine results in decreased expression of NME3 mRNA decreases expression
mRNA 18247414
D009538 4843 NOS2
HEP-NOS
INOS
NOS
NOS2A
nitric oxide synthase 2, inducible (EC:1.14.13.39) Nicotine promotes the reaction [NOS2 protein results in increased abundance of Nitric Oxide] increases abundance
/ increases reaction
protein 16927020
D009538 4843 NOS2
HEP-NOS
INOS
NOS
NOS2A
nitric oxide synthase 2, inducible (EC:1.14.13.39) Nicotine results in increased expression of NOS2 mRNA increases expression
mRNA 18247414
D009538 4843 NOS2
HEP-NOS
INOS
NOS
NOS2A
nitric oxide synthase 2, inducible (EC:1.14.13.39) Nicotine results in increased expression of NOS2 protein increases expression
protein 16927020
D009538 4846 NOS3
ECNOS
eNOS
nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) Nicotine results in increased expression of NOS3 mRNA increases expression
mRNA 11166759
D009538 4915 NTRK2
GP145-TrkB
TRKB
trk-B
neurotrophic tyrosine kinase, receptor, type 2 (EC:2.7.10.1) methyllycaconitine inhibits the reaction [Nicotine results in increased expression of NTRK2 protein] decreases reaction
/ increases expression
protein 16790237
D009538 4915 NTRK2
GP145-TrkB
TRKB
trk-B
neurotrophic tyrosine kinase, receptor, type 2 (EC:2.7.10.1) Nicotine results in increased expression of NTRK2 protein increases expression
protein 16790237
D009538 8473 OGT
HRNT1
O-GLCNAC
O-linked N-acetylglucosamine (GlcNAc) transferase (EC:2.4.1.255) Nicotine results in increased expression of OGT mRNA increases expression
mRNA 16949557
D009538 4986 OPRK1
K-OR-1
KOR
KOR-1
OPRK
opioid receptor, kappa 1 Nicotine results in decreased expression of OPRK1 mRNA decreases expression
mRNA 18247414
D009538 4999 ORC2
ORC2L
origin recognition complex, subunit 2 Nicotine results in increased expression of ORC2 mRNA increases expression
mRNA 16949557
D009538 79646 PANK3
pantothenate kinase 3 (EC:2.7.1.33) Nicotine results in increased expression of PANK3 mRNA increases expression
mRNA 16949557
D009538 5071 PARK2
AR-JP
LPRS2
PDJ
PRKN
parkin RBR E3 ubiquitin protein ligase Nicotine results in decreased expression of PARK2 mRNA decreases expression
mRNA 16949557
D009538 3355109 Nicotine inhibits the reaction [Aflatoxin B1 results in increased expression of PARP protein modified form] decreases reaction
/ increases expression
protein 22743290
D009538 142 PARP1
ADPRT
ADPRT_1
ADPRT1
ARTD1
PARP
PARP-1
PPOL
pADPRT-1
poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) Nicotine inhibits the reaction [Etoposide results in increased cleavage of PARP1 protein] decreases reaction
/ increases cleavage
protein 20457658
D009538 5111 PCNA
proliferating cell nuclear antigen Nicotine results in increased expression of PCNA protein increases expression
protein 18448488
20106947
D009538 5155 PDGFB
IBGC5
PDGF-2
PDGF2
SIS
SSV
c-sis
platelet-derived growth factor beta polypeptide 6,7-dimethoxy-2-phenylquinoxaline inhibits the reaction [Nicotine results in increased expression of PDGFB mRNA] decreases reaction
/ increases expression
mRNA 16149045
D009538 5155 PDGFB
IBGC5
PDGF-2
PDGF2
SIS
SSV
c-sis
platelet-derived growth factor beta polypeptide 6,7-dimethoxy-2-phenylquinoxaline inhibits the reaction [Nicotine results in increased secretion of PDGFB protein] decreases reaction
/ increases secretion
protein 16149045
D009538 5155 PDGFB
IBGC5
PDGF-2
PDGF2
SIS
SSV
c-sis
platelet-derived growth factor beta polypeptide Nicotine results in increased expression of PDGFB mRNA increases expression
mRNA 16149045
D009538 5155 PDGFB
IBGC5
PDGF-2
PDGF2
SIS
SSV
c-sis
platelet-derived growth factor beta polypeptide Nicotine results in increased secretion of PDGFB protein increases secretion
protein 16149045
D009538 5159 PDGFRB
CD140B
IBGC4
IMF1
JTK12
PDGFR
PDGFR-1
PDGFR1
platelet-derived growth factor receptor, beta polypeptide (EC:2.7.10.1) 6,7-dimethoxy-2-phenylquinoxaline inhibits the reaction [Nicotine results in increased expression of PDGFRB protein] decreases reaction
/ increases expression
protein 16149045
D009538 5159 PDGFRB
CD140B
IBGC4
IMF1
JTK12
PDGFR
PDGFR-1
PDGFR1
platelet-derived growth factor receptor, beta polypeptide (EC:2.7.10.1) Nicotine results in increased expression of PDGFRB protein increases expression
protein 16149045
D009538 51317 PHF21A
BHC80
PHD finger protein 21A Nicotine results in increased expression of PHF21A mRNA increases expression
mRNA 16949557
D009538 23469 PHF3
PHD finger protein 3 Nicotine results in increased expression of PHF3 mRNA increases expression
mRNA 16949557
D009538 35178 PHLPP gene SNP affects the susceptibility to Nicotine affects response to substance
gene 18438686
D009538 5281 PIGF
phosphatidylinositol glycan anchor biosynthesis, class F (EC:2.7.8.1) Nicotine results in increased expression of PIGF mRNA increases expression
mRNA 16949557
D009538 5290 PIK3CA
CLOVE
CWS5
MCAP
MCM
MCMTC
PI3K
p110-alpha
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha (EC:2.7.11.1 2.7.1.153) Nicotine results in increased expression of PIK3CA mRNA increases expression
mRNA 16949557
D009538 5586 PKN2
PAK2
PRK2
PRKCL2
PRO2042
Pak-2
protein kinase N2 (EC:2.7.11.13) Nicotine results in increased expression of PKN2 mRNA increases expression
mRNA 16949557
D009538 5327 PLAT
T-PA
TPA
plasminogen activator, tissue (EC:3.4.21.68) Nicotine affects the expression of PLAT mRNA affects expression
mRNA 18986645
D009538 5327 PLAT
T-PA
TPA
plasminogen activator, tissue (EC:3.4.21.68) [Nicotine co-treated with lipopolysaccharide, E. coli 026-B6] affects the expression of PLAT mRNA affects cotreatment
/ affects expression
mRNA 18986645
D009538 5327 PLAT
T-PA
TPA
plasminogen activator, tissue (EC:3.4.21.68) Nicotine results in increased expression of PLAT mRNA increases expression
mRNA 11166759
17151781
D009538 5327 PLAT
T-PA
TPA
plasminogen activator, tissue (EC:3.4.21.68) Nicotine results in increased expression of PLAT protein increases expression
protein 17151781
D009538 5328 PLAU
ATF
BDPLT5
QPD
UPA
URK
u-PA
plasminogen activator, urokinase (EC:3.4.21.73) L 663536 inhibits the reaction [Nicotine results in increased expression of PLAU mRNA] decreases reaction
/ increases expression
mRNA 20061081
D009538 5328 PLAU
ATF
BDPLT5
QPD
UPA
URK
u-PA
plasminogen activator, urokinase (EC:3.4.21.73) Nicotine results in increased expression of PLAU mRNA increases expression
mRNA 20061081
D009538 5329 PLAUR
CD87
U-PAR
UPAR
URKR
plasminogen activator, urokinase receptor 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Nicotine results in increased expression of PLAUR mRNA] decreases reaction
/ increases expression
mRNA 22261521
D009538 5329 PLAUR
CD87
U-PAR
UPAR
URKR
plasminogen activator, urokinase receptor Acetylcysteine inhibits the reaction [Nicotine results in increased expression of PLAUR mRNA] decreases reaction
/ increases expression
mRNA 22261521
D009538 5329 PLAUR
CD87
U-PAR
UPAR
URKR
plasminogen activator, urokinase receptor anthra(1,9-cd)pyrazol-6(2H)-one inhibits the reaction [Nicotine results in increased expression of PLAUR mRNA] decreases reaction
/ increases expression
mRNA 22261521
D009538 5329 PLAUR
CD87
U-PAR
UPAR
URKR
plasminogen activator, urokinase receptor L 663536 inhibits the reaction [Nicotine results in increased expression of PLAUR mRNA] decreases reaction
/ increases expression
mRNA 20061081
D009538 5329 PLAUR
CD87
U-PAR
UPAR
URKR
plasminogen activator, urokinase receptor Nicotine results in increased expression of PLAUR mRNA increases expression
mRNA 20061081
22261521
D009538 5329 PLAUR
CD87
U-PAR
UPAR
URKR
plasminogen activator, urokinase receptor Nicotine results in increased expression of PLAUR protein increases expression
protein 22261521
D009538 5337 PLD1
phospholipase D1, phosphatidylcholine-specific (EC:3.1.4.4) Nicotine results in decreased expression of PLD1 mRNA decreases expression
mRNA 18247414
D009538 5338 PLD2
phospholipase D2 (EC:3.1.4.4) Nicotine results in increased expression of PLD2 mRNA increases expression
mRNA 18247414
D009538 57480 PLEKHG1
ARHGEF41
pleckstrin homology domain containing, family G (with RhoGef domain) member 1 PLEKHG1 gene SNP affects the susceptibility to Nicotine affects response to substance
gene 18438686
D009538 5409 PNMT
PENT
PNMTase
phenylethanolamine N-methyltransferase (EC:2.1.1.28) Nicotine results in increased expression of PNMT mRNA increases expression
mRNA 17498763
D009538 8228 PNPLA4
DXS1283E
GS2
iPLA2eta
patatin-like phospholipase domain containing 4 (EC:3.1.1.3) Nicotine results in decreased expression of PNPLA4 mRNA decreases expression
mRNA 16949557
D009538 5445 PON2
paraoxonase 2 (EC:3.1.1.2 3.1.1.81) Nicotine results in increased expression of PON2 mRNA increases expression
mRNA 16949557
D009538 5450 POU2AF1
BOB1
OBF-1
OBF1
OCAB
POU class 2 associating factor 1 Nicotine results in decreased expression of POU2AF1 mRNA decreases expression
mRNA 18247414
D009538 5451 POU2F1
OCT1
OTF1
oct-1B
POU class 2 homeobox 1 Nicotine results in increased expression of POU2F1 mRNA increases expression
mRNA 18247414
D009538 5460 POU5F1
OCT3
OCT4
OTF-3
OTF3
OTF4
Oct-3
Oct-4
POU class 5 homeobox 1 Nicotine results in increased expression of POU5F1 mRNA increases expression
mRNA 23219715
D009538 5460 POU5F1
OCT3
OCT4
OTF-3
OTF3
OTF4
Oct-3
Oct-4
POU class 5 homeobox 1 Nicotine results in increased expression of POU5F1 protein increases expression
protein 23219715
D009538 5460 POU5F1
OCT3
OCT4
OTF-3
OTF3
OTF4
Oct-3
Oct-4
POU class 5 homeobox 1 SNAI1 mutant form inhibits the reaction [Nicotine results in increased expression of POU5F1 mRNA] decreases reaction
/ increases expression
mRNA 23219715
D009538 5523 PPP2R3A
PPP2R3
PR130
PR72
protein phosphatase 2, regulatory subunit B'', alpha (EC:3.1.3.16) Nicotine results in increased expression of PPP2R3A mRNA increases expression
mRNA 16949557
D009538 5577 PRKAR2B
PRKAR2
RII-BETA
protein kinase, cAMP-dependent, regulatory, type II, beta (EC:2.7.11.1) Nicotine results in increased expression of PRKAR2B mRNA increases expression
mRNA 18247414
D009538 5578 PRKCA
AAG6
PKC-alpha
PKCA
PRKACA
protein kinase C, alpha (EC:2.7.11.13) Nicotine results in increased activity of PRKCA protein increases activity
protein 12421819
D009538 5579 PRKCB
PKC-beta
PKCB
PRKCB1
PRKCB2
protein kinase C, beta (EC:2.7.11.13) Nicotine affects the localization of PRKCB protein affects localization
protein 17003101
D009538 5589 PRKCSH
AGE-R2
G19P1
PCLD
PKCSH
PLD1
protein kinase C substrate 80K-H (EC:2.7.11.1) Nicotine results in decreased expression of PRKCSH mRNA decreases expression
mRNA 16949557
D009538 5590 PRKCZ
PKC-ZETA
PKC2
protein kinase C, zeta (EC:2.7.11.13) Nicotine results in increased activity of PRKCZ protein increases activity
protein 17525161
D009538 5590 PRKCZ
PKC-ZETA
PKC2
protein kinase C, zeta (EC:2.7.11.13) PRKCZ protein affects the reaction [Nicotine results in increased phosphorylation of BAX protein] affects reaction
/ increases phosphorylation
protein 17525161
D009538 55119 PRPF38B
NET1
RP11-293A10.1
pre-mRNA processing factor 38B Nicotine results in increased expression of PRPF38B mRNA increases expression
mRNA 16949557
D009538 23215 PRRC2C
BAT2-iso
BAT2D1
BAT2L2
XTP2
proline-rich coiled-coil 2C Nicotine results in increased expression of PRRC2C mRNA increases expression
mRNA 16949557
D009538 5644 PRSS1
TRP1
TRY1
TRY4
TRYP1
protease, serine, 1 (trypsin 1) (EC:3.4.21.4) Nicotine results in decreased expression of PRSS1 mRNA decreases expression
mRNA 16949557
D009538 5694 PSMB6
DELTA
LMPY
Y
proteasome (prosome, macropain) subunit, beta type, 6 (EC:3.4.25.1) Nicotine results in decreased expression of PSMB6 mRNA decreases expression
mRNA 18247414
D009538 5724 PTAFR
PAFR
platelet-activating factor receptor Nicotine results in decreased expression of PTAFR mRNA decreases expression
mRNA 18247414
D009538 58155 PTBP2
PTB
PTBLP
brPTB
nPTB
nPTB5
nPTB6
nPTB7
nPTB8
polypyrimidine tract binding protein 2 Nicotine results in increased expression of PTBP2 mRNA increases expression
mRNA 16949557
D009538 5743 PTGS2
COX-2
COX2
GRIPGHS
PGG/HS
PGHS-2
PHS-2
hCox-2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) [4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide results in decreased activity of PTGS2 protein] inhibits the reaction [Nicotine results in increased abundance of Dinoprostone] decreases activity
/ decreases reaction
/ increases abundance
protein 18805435
D009538 5743 PTGS2
COX-2
COX2
GRIPGHS
PGG/HS
PGHS-2
PHS-2
hCox-2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) [Atenolol binds to and results in decreased activity of ADRB1 protein] inhibits the reaction [Nicotine results in increased expression of PTGS2 protein] affects binding
/ decreases activity
/ decreases reaction
/ increases expression
protein 17003101
D009538 5743 PTGS2
COX-2
COX2
GRIPGHS
PGG/HS
PGHS-2
PHS-2
hCox-2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) Curcumin inhibits the reaction [Nicotine results in increased expression of PTGS2 protein] decreases reaction
/ increases expression
protein 20727180
D009538 5743 PTGS2
COX-2
COX2
GRIPGHS
PGG/HS
PGHS-2
PHS-2
hCox-2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) [ICI 118551 binds to and results in decreased activity of ADRB2 protein] inhibits the reaction [Nicotine results in increased expression of PTGS2] affects binding
/ decreases activity
/ decreases reaction
/ increases expression
17369603
D009538 5743 PTGS2
COX-2
COX2
GRIPGHS
PGG/HS
PGHS-2
PHS-2
hCox-2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) [ICI 118551 binds to and results in decreased activity of ADRB2 protein] inhibits the reaction [Nicotine results in increased expression of PTGS2 protein] affects binding
/ decreases activity
/ decreases reaction
/ increases expression
protein 17003101
D009538 5743 PTGS2
COX-2
COX2
GRIPGHS
PGG/HS
PGHS-2
PHS-2
hCox-2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) lipopolysaccharide, E. coli 026-B6 promotes the reaction [Nicotine results in increased expression of PTGS2 mRNA] increases expression
/ increases reaction
mRNA 18986645
D009538 5743 PTGS2
COX-2
COX2
GRIPGHS
PGG/HS
PGHS-2
PHS-2
hCox-2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) Nicotine promotes the reaction [lipopolysaccharide, E. coli 026-B6 results in increased expression of PTGS2 mRNA] increases expression
/ increases reaction
mRNA 18986645
D009538 5743 PTGS2
COX-2
COX2
GRIPGHS
PGG/HS
PGHS-2
PHS-2
hCox-2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) Nicotine results in increased activity of PTGS2 protein increases activity
protein 17003101
18805435
D009538 5743 PTGS2
COX-2
COX2
GRIPGHS
PGG/HS
PGHS-2
PHS-2
hCox-2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) Nicotine results in increased expression of PTGS2 mRNA increases expression
mRNA 17003101
17369603
18986645
D009538 5743 PTGS2
COX-2
COX2
GRIPGHS
PGG/HS
PGHS-2
PHS-2
hCox-2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) Nicotine results in increased expression of PTGS2 protein increases expression
protein 20727180
D009538 5743 PTGS2
COX-2
COX2
GRIPGHS
PGG/HS
PGHS-2
PHS-2
hCox-2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) Propranolol inhibits the reaction [Nicotine results in increased activity of PTGS2 protein] decreases reaction
/ increases activity
protein 18805435
D009538 5743 PTGS2
COX-2
COX2
GRIPGHS
PGG/HS
PGHS-2
PHS-2
hCox-2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) Staurosporine inhibits the reaction [Nicotine results in increased expression of PTGS2] decreases reaction
/ increases expression
17003101
D009538 5743 PTGS2
COX-2
COX2
GRIPGHS
PGG/HS
PGHS-2
PHS-2
hCox-2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) [U 0126 results in decreased activity of [MAPK1 protein co-treated with MAPK3 protein]] inhibits the reaction [Nicotine results in increased expression of PTGS2] affects cotreatment
/ decreases activity
/ decreases reaction
/ increases expression
17003101
D009538 5786 PTPRA
HEPTP
HLPR
HPTPA
HPTPalpha
LRP
PTPA
PTPRL2
R-PTP-alpha
RPTPA
protein tyrosine phosphatase, receptor type, A (EC:3.1.3.48) alpha-cobratoxin inhibits the reaction [Nicotine results in decreased expression of PTPRA mRNA] decreases expression
/ decreases reaction
mRNA 12588870
D009538 5786 PTPRA
HEPTP
HLPR
HPTPA
HPTPalpha
LRP
PTPA
PTPRL2
R-PTP-alpha
RPTPA
protein tyrosine phosphatase, receptor type, A (EC:3.1.3.48) Mecamylamine inhibits the reaction [Nicotine results in decreased expression of PTPRA mRNA] decreases expression
/ decreases reaction
mRNA 12588870
D009538 5786 PTPRA
HEPTP
HLPR
HPTPA
HPTPalpha
LRP
PTPA
PTPRL2
R-PTP-alpha
RPTPA
protein tyrosine phosphatase, receptor type, A (EC:3.1.3.48) Nicotine results in decreased expression of PTPRA mRNA decreases expression
mRNA 12588870
D009538 5786 PTPRA
HEPTP
HLPR
HPTPA
HPTPalpha
LRP
PTPA
PTPRL2
R-PTP-alpha
RPTPA
protein tyrosine phosphatase, receptor type, A (EC:3.1.3.48) Tubocurarine inhibits the reaction [Nicotine results in decreased expression of PTPRA mRNA] decreases expression
/ decreases reaction
mRNA 12588870
D009538 5806 PTX3
TNFAIP5
TSG-14
pentraxin 3, long Nicotine results in decreased expression of PTX3 mRNA decreases expression
mRNA 18247414
D009538 5870 RAB6A
RAB6
RAB6A, member RAS oncogene family Nicotine results in decreased expression of RAB6A mRNA decreases expression
mRNA 12588870
D009538 10111 RAD50
NBSLD
RAD502
hRad50
RAD50 homolog (S. cerevisiae) Nicotine results in increased expression of RAD50 mRNA increases expression
mRNA 16949557
D009538 5894 RAF1
CRAF
NS5
Raf-1
c-Raf
v-raf-1 murine leukemia viral oncogene homolog 1 (EC:2.7.11.1) Aconitine analog inhibits the reaction [Nicotine promotes the reaction [RB1 protein binds to RAF1 protein]] affects binding
/ decreases reaction
/ increases reaction
protein 16862215
D009538 5894 RAF1
CRAF
NS5
Raf-1
c-Raf
v-raf-1 murine leukemia viral oncogene homolog 1 (EC:2.7.11.1) ARRB1 protein affects the reaction [Nicotine promotes the reaction [RB1 protein binds to RAF1 protein]] affects binding
/ affects reaction
/ increases reaction
protein 16862215
D009538 5894 RAF1
CRAF
NS5
Raf-1
c-Raf
v-raf-1 murine leukemia viral oncogene homolog 1 (EC:2.7.11.1) Bungarotoxins inhibits the reaction [Nicotine promotes the reaction [RB1 protein binds to RAF1 protein]] affects binding
/ decreases reaction
/ increases reaction
protein 16862215
D009538 5894 RAF1
CRAF
NS5
Raf-1
c-Raf
v-raf-1 murine leukemia viral oncogene homolog 1 (EC:2.7.11.1) CHRNA7 protein affects the reaction [Nicotine promotes the reaction [RB1 protein binds to RAF1 protein]] affects binding
/ affects reaction
/ increases reaction
protein 16862215
D009538 5894 RAF1
CRAF
NS5
Raf-1
c-Raf
v-raf-1 murine leukemia viral oncogene homolog 1 (EC:2.7.11.1) Nicotine promotes the reaction [RB1 protein binds to RAF1 protein] affects binding
/ increases reaction
protein 16862215
D009538 5894 RAF1
CRAF
NS5
Raf-1
c-Raf
v-raf-1 murine leukemia viral oncogene homolog 1 (EC:2.7.11.1) Nicotine results in increased activity of RAF1 protein increases activity
protein 17459420
D009538 5894 RAF1
CRAF
NS5
Raf-1
c-Raf
v-raf-1 murine leukemia viral oncogene homolog 1 (EC:2.7.11.1) SRC protein affects the reaction [Nicotine promotes the reaction [RB1 protein binds to RAF1 protein]] affects binding
/ affects reaction
/ increases reaction
protein 16862215
D009538 5916 RARG
NR1B3
RARC
retinoic acid receptor, gamma Nicotine results in decreased expression of RARG mRNA decreases expression
mRNA 18247414
D009538 5925 RB1
OSRC
RB
p105-Rb
pRb
pp110
retinoblastoma 1 4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide inhibits the reaction [Nicotine results in increased phosphorylation of RB1 protein] decreases reaction
/ increases phosphorylation
protein 18805435
D009538 5925 RB1
OSRC
RB
p105-Rb
pRb
pp110
retinoblastoma 1 Aconitine analog inhibits the reaction [Nicotine promotes the reaction [RB1 protein binds to RAF1 protein]] affects binding
/ decreases reaction
/ increases reaction
protein 16862215
D009538 5925 RB1
OSRC
RB
p105-Rb
pRb
pp110
retinoblastoma 1 ARRB1 protein affects the reaction [Nicotine promotes the reaction [RB1 protein binds to RAF1 protein]] affects binding
/ affects reaction
/ increases reaction
protein 16862215
D009538 5925 RB1
OSRC
RB
p105-Rb
pRb
pp110
retinoblastoma 1 Bungarotoxins inhibits the reaction [Nicotine promotes the reaction [RB1 protein binds to RAF1 protein]] affects binding
/ decreases reaction
/ increases reaction
protein 16862215
D009538 5925 RB1
OSRC
RB
p105-Rb
pRb
pp110
retinoblastoma 1 CHRNA7 protein affects the reaction [Nicotine promotes the reaction [RB1 protein binds to RAF1 protein]] affects binding
/ affects reaction
/ increases reaction
protein 16862215
D009538 5925 RB1
OSRC
RB
p105-Rb
pRb
pp110
retinoblastoma 1 L 663536 inhibits the reaction [Nicotine results in increased expression of RB1 protein modified form] decreases reaction
/ increases expression
protein 20061081
D009538 5925 RB1
OSRC
RB
p105-Rb
pRb
pp110
retinoblastoma 1 Nicotine inhibits the reaction [RB1 protein binds to BIRC5 promoter] affects binding
/ decreases reaction
protein 16601104
D009538 5925 RB1
OSRC
RB
p105-Rb
pRb
pp110
retinoblastoma 1 Nicotine inhibits the reaction [RB1 protein binds to CDC25A promoter] affects binding
/ decreases reaction
protein 16862215
D009538 5925 RB1
OSRC
RB
p105-Rb
pRb
pp110
retinoblastoma 1 Nicotine inhibits the reaction [RB1 protein binds to CDC6 promoter] affects binding
/ decreases reaction
protein 16862215
D009538 5925 RB1
OSRC
RB
p105-Rb
pRb
pp110
retinoblastoma 1 Nicotine promotes the reaction [RB1 protein binds to RAF1 protein] affects binding
/ increases reaction
protein 16862215
D009538 5925 RB1
OSRC
RB
p105-Rb
pRb
pp110
retinoblastoma 1 Nicotine results in decreased expression of RB1 protein decreases expression
protein 16011614
D009538 5925 RB1
OSRC
RB
p105-Rb
pRb
pp110
retinoblastoma 1 Nicotine results in increased expression of RB1 protein modified form increases expression
protein 20061081
D009538 5925 RB1
OSRC
RB
p105-Rb
pRb
pp110
retinoblastoma 1 Nicotine results in increased phosphorylation of RB1 protein increases phosphorylation
protein 16862215
18448488
18805435
D009538 5925 RB1
OSRC
RB
p105-Rb
pRb
pp110
retinoblastoma 1 SRC protein affects the reaction [Nicotine promotes the reaction [RB1 protein binds to RAF1 protein]] affects binding
/ affects reaction
/ increases reaction
protein 16862215
D009538 5930 RBBP6
MY038
P2P-R
PACT
RBQ-1
SNAMA
retinoblastoma binding protein 6 alpha-cobratoxin inhibits the reaction [Nicotine results in decreased expression of RBBP6 mRNA] decreases expression
/ decreases reaction
mRNA 12588870
D009538 5930 RBBP6
MY038
P2P-R
PACT
RBQ-1
SNAMA
retinoblastoma binding protein 6 Mecamylamine inhibits the reaction [Nicotine results in decreased expression of RBBP6 mRNA] decreases expression
/ decreases reaction
mRNA 12588870
D009538 5930 RBBP6
MY038
P2P-R
PACT
RBQ-1
SNAMA
retinoblastoma binding protein 6 Nicotine results in decreased expression of RBBP6 mRNA decreases expression
mRNA 12588870
D009538 5930 RBBP6
MY038
P2P-R
PACT
RBQ-1
SNAMA
retinoblastoma binding protein 6 Nicotine results in increased expression of RBBP6 mRNA increases expression
mRNA 16949557
D009538 5930 RBBP6
MY038
P2P-R
PACT
RBQ-1
SNAMA
retinoblastoma binding protein 6 Tubocurarine inhibits the reaction [Nicotine results in decreased expression of RBBP6 mRNA] decreases expression
/ decreases reaction
mRNA 12588870
D009538 146713 RBFOX3
FOX-3
FOX3
HRNBP3
NEUN
RNA binding protein, fox-1 homolog (C. elegans) 3 Nicotine results in increased expression of RBFOX3 protein increases expression
protein 20457658
D009538 5933 RBL1
CP107
PRB1
p107
retinoblastoma-like 1 (p107) Nicotine inhibits the reaction [RBL1 protein binds to CDC25A promoter] affects binding
/ decreases reaction
protein 16862215
D009538 5933 RBL1
CP107
PRB1
p107
retinoblastoma-like 1 (p107) Nicotine inhibits the reaction [RBL1 protein binds to CDC6 promoter] affects binding
/ decreases reaction
protein 16862215
D009538 5934 RBL2
P130
Rb2
retinoblastoma-like 2 (p130) Nicotine inhibits the reaction [RBL2 protein binds to CDC25A promoter] affects binding
/ decreases reaction
protein 16862215
D009538 5934 RBL2
P130
Rb2
retinoblastoma-like 2 (p130) Nicotine inhibits the reaction [RBL2 protein binds to CDC6 promoter] affects binding
/ decreases reaction
protein 16862215
D009538 58517 RBM25
NET52
RED120
RNPC7
S164
Snu71
fSAP94
RNA binding motif protein 25 Nicotine results in increased expression of RBM25 mRNA increases expression
mRNA 16949557
D009538 5970 RELA
NFKB3
p65
v-rel avian reticuloendotheliosis viral oncogene homolog A [alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide co-treated with U 0126] inhibits the reaction [Nicotine promotes the reaction [RELA protein binds to STAT3 protein modified form]] affects binding
/ affects cotreatment
/ decreases reaction
/ increases reaction
protein 18448488
D009538 5970 RELA
NFKB3
p65
v-rel avian reticuloendotheliosis viral oncogene homolog A alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [Nicotine promotes the reaction [RELA protein binds to STAT3 protein modified form]] affects binding
/ decreases reaction
/ increases reaction
protein 18448488
D009538 5970 RELA
NFKB3
p65
v-rel avian reticuloendotheliosis viral oncogene homolog A Nicotine affects the localization of and results in increased activity of RELA protein affects localization
/ increases activity
protein 16254210
D009538 5970 RELA
NFKB3
p65
v-rel avian reticuloendotheliosis viral oncogene homolog A Nicotine promotes the reaction [RELA protein binds to STAT3 protein modified form] affects binding
/ increases reaction
protein 18448488
D009538 5970 RELA
NFKB3
p65
v-rel avian reticuloendotheliosis viral oncogene homolog A U 0126 inhibits the reaction [Nicotine promotes the reaction [RELA protein binds to STAT3 protein modified form]] affects binding
/ decreases reaction
/ increases reaction
protein 18448488
D009538 5994 RFXAP
regulatory factor X-associated protein Nicotine results in decreased expression of RFXAP mRNA decreases expression
mRNA 12588870
D009538 5996 RGS1
1R20
BL34
IER1
IR20
regulator of G-protein signaling 1 Nicotine results in increased expression of RGS1 mRNA increases expression
mRNA 18247414
D009538 6018 RLF
ZN-15L
ZNF292L
rearranged L-myc fusion Nicotine results in increased expression of RLF mRNA increases expression
mRNA 16949557
D009538 6130 RPL7A
L7A
SURF3
TRUP
ribosomal protein L7a Nicotine results in decreased expression of RPL7A mRNA decreases expression
mRNA 18247414
D009538 6230 RPS25
S25
ribosomal protein S25 Nicotine results in increased expression of RPS25 mRNA increases expression
mRNA 18247414
D009538 57521 RPTOR
KOG1
Mip1
regulatory associated protein of MTOR, complex 1 RPTOR gene SNP affects the susceptibility to Nicotine affects response to substance
gene 18438686
D009538 862 RUNX1T1
AML1T1
CBFA2T1
CDR
ETO
MTG8
ZMYND2
runt-related transcription factor 1; translocated to, 1 (cyclin D-related) Nicotine results in decreased expression of RUNX1T1 mRNA decreases expression
mRNA 18247414
D009538 6281 S100A10
42C
ANX2L
ANX2LG
CAL1L
CLP11
Ca[1]
GP11
P11
p10
S100 calcium binding protein A10 Nicotine results in decreased expression of S100A10 mRNA decreases expression
mRNA 18247414
D009538 44263 Nicotine results in decreased expression of SARA mRNA decreases expression
mRNA 18247414
D009538 66234 Nicotine results in increased expression of SC4MOL mRNA increases expression
mRNA 23416264
D009538 9169 SCAF11
CASP11
SFRS2IP
SIP1
SRRP129
SRSF2IP
SR-related CTD-associated factor 11 Nicotine results in increased expression of SCAF11 mRNA increases expression
mRNA 16949557
D009538 23480 SEC61G
SSS1
Sec61 gamma subunit Nicotine results in increased expression of SEC61G mRNA increases expression
mRNA 16949557
D009538 10955 SERINC3
AIGP1
DIFF33
SBBI99
TDE
TDE1
TMS-1
serine incorporator 3 Nicotine results in increased expression of SERINC3 mRNA increases expression
mRNA 16949557
D009538 5054 SERPINE1
PAI
PAI-1
PAI1
PLANH1
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 Nicotine results in increased expression of SERPINE1 mRNA increases expression
mRNA 11166759
D009538 871 SERPINH1
AsTP3
CBP1
CBP2
HSP47
OI10
PPROM
RA-A47
SERPINH2
gp46
serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) Nicotine results in decreased expression of SERPINH1 mRNA decreases expression
mRNA 16949557
D009538 51639 SF3B14
HSPC175
Ht006
P14
SAP14
SF3B14a
splicing factor 3B, 14 kDa subunit Nicotine results in increased expression of SF3B14 mRNA increases expression
mRNA 16949557
D009538 10572 SIVA1
CD27BP
SIVA
Siva-1
Siva-2
SIVA1, apoptosis-inducing factor Nicotine results in decreased expression of SIVA1 mRNA decreases expression
mRNA 16949557
D009538 6573 SLC19A1
CHMD
FOLT
IFC1
REFC
RFC1
solute carrier family 19 (folate transporter), member 1 Nicotine results in decreased expression of SLC19A1 mRNA decreases expression
mRNA 19616087
D009538 10559 SLC35A1
CDG2F
CMPST
CST
hCST
solute carrier family 35 (CMP-sialic acid transporter), member A1 Nicotine results in increased expression of SLC35A1 mRNA increases expression
mRNA 16949557
D009538 25800 SLC39A6
LIV-1
solute carrier family 39 (zinc transporter), member 6 Nicotine results in increased expression of SLC39A6 mRNA increases expression
mRNA 16949557
D009538 9351 SLC9A3R2
E3KARP
NHE3RF2
NHERF-2
NHERF2
OCTS2
SIP-1
SIP1
TKA-1
solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2 Nicotine results in decreased expression of SLC9A3R2 mRNA decreases expression
mRNA 18247414
D009538 4093 SMAD9
MADH6
MADH9
PPH2
SMAD8
SMAD8A
SMAD8B
SMAD family member 9 Nicotine results in increased expression of SMAD9 mRNA increases expression
mRNA 18247414
D009538 6615 SNAI1
SLUGH2
SNA
SNAH
SNAIL
SNAIL1
dJ710H13.1
snail family zinc finger 1 Nicotine results in increased expression of SNAI1 mRNA increases expression
mRNA 23219715
D009538 6615 SNAI1
SLUGH2
SNA
SNAH
SNAIL
SNAIL1
dJ710H13.1
snail family zinc finger 1 Nicotine results in increased expression of SNAI1 protein increases expression
protein 23219715
D009538 6615 SNAI1
SLUGH2
SNA
SNAH
SNAIL
SNAIL1
dJ710H13.1
snail family zinc finger 1 SNAI1 mutant form inhibits the reaction [Nicotine results in increased expression of BMI1 mRNA] decreases reaction
/ increases expression
mutant form 23219715
D009538 6615 SNAI1
SLUGH2
SNA
SNAH
SNAIL
SNAIL1
dJ710H13.1
snail family zinc finger 1 SNAI1 mutant form inhibits the reaction [Nicotine results in increased expression of NANOG mRNA] decreases reaction
/ increases expression
mutant form 23219715
D009538 6615 SNAI1
SLUGH2
SNA
SNAH
SNAIL
SNAIL1
dJ710H13.1
snail family zinc finger 1 SNAI1 mutant form inhibits the reaction [Nicotine results in increased expression of POU5F1 mRNA] decreases reaction
/ increases expression
mutant form 23219715
D009538 6615 SNAI1
SLUGH2
SNA
SNAH
SNAIL
SNAIL1
dJ710H13.1
snail family zinc finger 1 SNAI1 results in increased susceptibility to Nicotine increases response to substance
23219715
D009538 6591 SNAI2
SLUG
SLUGH1
SNAIL2
WS2D
snail family zinc finger 2 Nicotine results in increased expression of SNAI2 mRNA increases expression
mRNA 23219715
D009538 6619 SNAPC3
PTFbeta
SNAP50
small nuclear RNA activating complex, polypeptide 3, 50kDa Nicotine results in increased expression of SNAPC3 mRNA increases expression
mRNA 16949557
D009538 6622 SNCA
NACP
PARK1
PARK4
PD1
synuclein, alpha (non A4 component of amyloid precursor) Nicotine results in increased expression of SNCA mRNA increases expression
mRNA 18247414
D009538 252672 Nicotine results in decreased expression of SNL mRNA decreases expression
mRNA 18247414
D009538 6647 SOD1
ALS
ALS1
IPOA
SOD
hSod1
homodimer
superoxide dismutase 1, soluble (EC:1.15.1.1) Nicotine results in decreased expression of SOD1 protein decreases expression
protein 16627626
D009538 6654 SOS1
GF1
GGF1
GINGF
HGF
NS4
son of sevenless homolog 1 (Drosophila) alpha-cobratoxin inhibits the reaction [Nicotine results in increased expression of SOS1 mRNA] decreases reaction
/ increases expression
mRNA 16949557
D009538 6654 SOS1
GF1
GGF1
GINGF
HGF
NS4
son of sevenless homolog 1 (Drosophila) Mecamylamine inhibits the reaction [Nicotine results in increased expression of SOS1 mRNA] decreases reaction
/ increases expression
mRNA 16949557
D009538 6654 SOS1
GF1
GGF1
GINGF
HGF
NS4
son of sevenless homolog 1 (Drosophila) Nicotine results in increased expression of SOS1 mRNA increases expression
mRNA 16949557
D009538 6654 SOS1
GF1
GGF1
GINGF
HGF
NS4
son of sevenless homolog 1 (Drosophila) Tubocurarine inhibits the reaction [Nicotine results in increased expression of SOS1 mRNA] decreases reaction
/ increases expression
mRNA 16949557
D009538 9043 SPAG9
CT89
HLC-6
HLC4
JIP-4
JIP4
JLP
PHET
PIG6
sperm associated antigen 9 Nicotine results in increased expression of SPAG9 mRNA increases expression
mRNA 16949557
D009538 6696 SPP1
BNSP
BSPI
ETA-1
OPN
secreted phosphoprotein 1 Nicotine results in increased expression of SPP1 protein increases expression
protein 11425648
D009538 6696 SPP1
BNSP
BSPI
ETA-1
OPN
secreted phosphoprotein 1 Tubocurarine inhibits the reaction [Nicotine results in increased expression of SPP1 protein] decreases reaction
/ increases expression
protein 11425648
D009538 6714 SRC
ASV
SRC1
c-SRC
p60-Src
v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (EC:2.7.10.2) ARRB1 protein affects the reaction [Nicotine results in increased phosphorylation of and results in increased activity of SRC protein] affects reaction
/ increases activity
/ increases phosphorylation
protein 16862215
D009538 6714 SRC
ASV
SRC1
c-SRC
p60-Src
v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (EC:2.7.10.2) Nicotine results in increased phosphorylation of and results in increased activity of SRC protein increases activity
/ increases phosphorylation
protein 16862215
D009538 6714 SRC
ASV
SRC1
c-SRC
p60-Src
v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (EC:2.7.10.2) Nicotine results in increased phosphorylation of SRC protein increases phosphorylation
protein 14569062
D009538 6714 SRC
ASV
SRC1
c-SRC
p60-Src
v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (EC:2.7.10.2) SRC protein affects the reaction [Nicotine promotes the reaction [RB1 protein binds to RAF1 protein]] affects binding
/ affects reaction
/ increases reaction
protein 16862215
D009538 6714 SRC
ASV
SRC1
c-SRC
p60-Src
v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (EC:2.7.10.2) tyrphostin AG 1478 inhibits the reaction [Nicotine results in increased phosphorylation of SRC protein] decreases reaction
/ increases phosphorylation
protein 14569062
D009538 6720 SREBF1
SREBP-1c
SREBP1
bHLHd1
sterol regulatory element binding transcription factor 1 Nicotine results in decreased expression of SREBF1 mRNA decreases expression
mRNA 18247414
D009538 400410 ST20
HCCS-1
suppressor of tumorigenicity 20 Nicotine results in increased expression of ST20 mRNA increases expression
mRNA 16949557
D009538 6770 STAR
STARD1
steroidogenic acute regulatory protein Nicotine results in decreased expression of STAR mRNA decreases expression
mRNA 21971485
D009538 6770 STAR
STARD1
steroidogenic acute regulatory protein Nicotine results in decreased expression of STAR protein decreases expression
protein 21971485
D009538 6770 STAR
STARD1
steroidogenic acute regulatory protein Nicotine results in increased methylation of STAR promoter increases methylation
promoter 21971485
D009538 6773 STAT2
ISGF-3
P113
STAT113
signal transducer and activator of transcription 2, 113kDa Nicotine results in decreased expression of STAT2 mRNA decreases expression
mRNA 18247414
D009538 6774 STAT3
APRF
HIES
signal transducer and activator of transcription 3 (acute-phase response factor) [alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide co-treated with U 0126] inhibits the reaction [Nicotine promotes the reaction [RELA protein binds to STAT3 protein modified form]] affects binding
/ affects cotreatment
/ decreases reaction
/ increases reaction
protein 18448488
D009538 6774 STAT3
APRF
HIES
signal transducer and activator of transcription 3 (acute-phase response factor) alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [Nicotine promotes the reaction [RELA protein binds to STAT3 protein modified form]] affects binding
/ decreases reaction
/ increases reaction
protein 18448488
D009538 6774 STAT3
APRF
HIES
signal transducer and activator of transcription 3 (acute-phase response factor) Hexamethonium inhibits the reaction [Nicotine results in increased phosphorylation of STAT3 protein] decreases reaction
/ increases phosphorylation
protein 18448488
20106947
D009538 6774 STAT3
APRF
HIES
signal transducer and activator of transcription 3 (acute-phase response factor) [Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of STAT3 protein] affects binding
/ decreases activity
/ decreases reaction
/ increases phosphorylation
protein 18448488
D009538 6774 STAT3
APRF
HIES
signal transducer and activator of transcription 3 (acute-phase response factor) Lobeline inhibits the reaction [Nicotine results in increased phosphorylation of STAT3 protein] decreases reaction
/ increases phosphorylation
protein 20106947
D009538 6774 STAT3
APRF
HIES
signal transducer and activator of transcription 3 (acute-phase response factor) [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased phosphorylation of STAT3 protein] affects binding
/ decreases activity
/ decreases reaction
/ increases phosphorylation
protein 18448488
D009538 6774 STAT3
APRF
HIES
signal transducer and activator of transcription 3 (acute-phase response factor) [Nicotine co-treated with Lipopolysaccharides] results in increased phosphorylation of STAT3 protein affects cotreatment
/ increases phosphorylation
protein 21606497
D009538 6774 STAT3
APRF
HIES
signal transducer and activator of transcription 3 (acute-phase response factor) Nicotine inhibits the reaction [Cisplatin results in decreased activity of STAT3 protein] decreases activity
/ decreases reaction
protein 20106947
D009538 6774 STAT3
APRF
HIES
signal transducer and activator of transcription 3 (acute-phase response factor) Nicotine inhibits the reaction [Paclitaxel results in decreased activity of STAT3 protein] decreases activity
/ decreases reaction
protein 20106947
D009538 6774 STAT3
APRF
HIES
signal transducer and activator of transcription 3 (acute-phase response factor) Nicotine promotes the reaction [RELA protein binds to STAT3 protein modified form] affects binding
/ increases reaction
protein 18448488
D009538 6774 STAT3
APRF
HIES
signal transducer and activator of transcription 3 (acute-phase response factor) Nicotine promotes the reaction [STAT3 protein binds to ZFP36 promoter] affects binding
/ increases reaction
protein 21606497
D009538 6774 STAT3
APRF
HIES
signal transducer and activator of transcription 3 (acute-phase response factor) Nicotine results in increased activity of STAT3 protein increases activity
protein 18448488
D009538 6774 STAT3
APRF
HIES
signal transducer and activator of transcription 3 (acute-phase response factor) Nicotine results in increased phosphorylation of and results in increased activity of STAT3 protein increases activity
/ increases phosphorylation
protein 20106947
D009538 6774 STAT3
APRF
HIES
signal transducer and activator of transcription 3 (acute-phase response factor) Nicotine results in increased phosphorylation of STAT3 protein increases phosphorylation
protein 18448488
D009538 6774 STAT3
APRF
HIES
signal transducer and activator of transcription 3 (acute-phase response factor) Propranolol inhibits the reaction [Nicotine results in increased phosphorylation of STAT3 protein] decreases reaction
/ increases phosphorylation
protein 18448488
20106947
D009538 6774 STAT3
APRF
HIES
signal transducer and activator of transcription 3 (acute-phase response factor) Staurosporine inhibits the reaction [Nicotine results in increased phosphorylation of STAT3 protein] decreases reaction
/ increases phosphorylation
protein 18448488
D009538 6774 STAT3
APRF
HIES
signal transducer and activator of transcription 3 (acute-phase response factor) U 0126 inhibits the reaction [Nicotine promotes the reaction [RELA protein binds to STAT3 protein modified form]] affects binding
/ decreases reaction
/ increases reaction
protein 18448488
D009538 6774 STAT3
APRF
HIES
signal transducer and activator of transcription 3 (acute-phase response factor) U 0126 inhibits the reaction [Nicotine results in increased activity of STAT3 protein] decreases reaction
/ increases activity
protein 18448488
D009538 6774 STAT3
APRF
HIES
signal transducer and activator of transcription 3 (acute-phase response factor) U 0126 inhibits the reaction [Nicotine results in increased phosphorylation of STAT3 protein] decreases reaction
/ increases phosphorylation
protein 18448488
D009538 6777 STAT5B
STAT5
signal transducer and activator of transcription 5B Nicotine results in increased expression of STAT5B mRNA increases expression
mRNA 18805435
D009538 6778 STAT6
D12S1644
IL-4-STAT
STAT6B
STAT6C
signal transducer and activator of transcription 6, interleukin-4 induced Nicotine results in increased expression of STAT6 mRNA increases expression
mRNA 18805435
D009538 8614 STC2
STC-2
STCRP
stanniocalcin 2 Nicotine results in increased expression of STC2 mRNA increases expression
mRNA 16949557
D009538 10963 STIP1
HOP
IEF-SSP-3521
P60
STI1
STI1L
stress-induced-phosphoprotein 1 Nicotine results in decreased expression of STIP1 mRNA decreases expression
mRNA 16949557
D009538 10963 STIP1
HOP
IEF-SSP-3521
P60
STI1
STI1L
stress-induced-phosphoprotein 1 Tubocurarine inhibits the reaction [Nicotine results in decreased expression of STIP1 mRNA] decreases expression
/ decreases reaction
mRNA 16949557
D009538 10494 STK25
SOK1
YSK1
serine/threonine kinase 25 (EC:2.7.11.1) Nicotine results in increased expression of STK25 mRNA increases expression
mRNA 18247414
D009538 6814 STXBP3
MUNC18-3
MUNC18C
PSP
UNC-18C
syntaxin binding protein 3 Nicotine results in increased expression of STXBP3 mRNA increases expression
mRNA 16949557
D009538 6827 SUPT4H1
SPT4
SPT4H
SUPT4H
suppressor of Ty 4 homolog 1 (S. cerevisiae) Nicotine results in decreased expression of SUPT4H1 mRNA decreases expression
mRNA 18247414
D009538 8407 TAGLN2
HA1756
transgelin 2 Nicotine results in decreased expression of TAGLN2 mRNA decreases expression
mRNA 16949557
D009538 57551 TAOK1
KFC-B
MAP3K16
MARKK
PSK-2
PSK2
TAO1
hKFC-B
hTAOK1
TAO kinase 1 (EC:2.7.11.1) Nicotine results in increased expression of TAOK1 mRNA increases expression
mRNA 16949557
D009538 7027 TFDP1
DP1
DRTF1
Dp-1
transcription factor Dp-1 L 663536 inhibits the reaction [Nicotine results in increased expression of TFDP1 protein] decreases reaction
/ increases expression
protein 20061081
D009538 7027 TFDP1
DP1
DRTF1
Dp-1
transcription factor Dp-1 Nicotine results in decreased expression of TFDP1 mRNA decreases expression
mRNA 18247414
D009538 7027 TFDP1
DP1
DRTF1
Dp-1
transcription factor Dp-1 Nicotine results in increased expression of TFDP1 protein increases expression
protein 20061081
D009538 7980 TFPI2
PP5
REF1
TFPI-2
tissue factor pathway inhibitor 2 alpha-cobratoxin inhibits the reaction [Nicotine results in decreased expression of TFPI2 mRNA] decreases expression
/ decreases reaction
mRNA 12588870
D009538 7980 TFPI2
PP5
REF1
TFPI-2
tissue factor pathway inhibitor 2 Mecamylamine inhibits the reaction [Nicotine results in decreased expression of TFPI2 mRNA] decreases expression
/ decreases reaction
mRNA 12588870
D009538 7980 TFPI2
PP5
REF1
TFPI-2
tissue factor pathway inhibitor 2 Nicotine results in decreased expression of TFPI2 mRNA decreases expression
mRNA 12588870
D009538 7980 TFPI2
PP5
REF1
TFPI-2
tissue factor pathway inhibitor 2 Nicotine results in increased expression of TFPI2 mRNA increases expression
mRNA 12588870
D009538 7037 TFRC
CD71
T9
TFR
TFR1
TR
TRFR
p90
transferrin receptor Nicotine results in increased expression of TFRC mRNA increases expression
mRNA 16949557
D009538 7054 TH
DYT14
DYT5b
TYH
tyrosine hydroxylase (EC:1.14.16.2) [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased expression of TH mRNA] affects binding
/ decreases activity
/ decreases reaction
/ increases expression
mRNA 17498763
D009538 7054 TH
DYT14
DYT5b
TYH
tyrosine hydroxylase (EC:1.14.16.2) Nicotine results in increased expression of TH mRNA increases expression
mRNA 17498763
D009538 7054 TH
DYT14
DYT5b
TYH
tyrosine hydroxylase (EC:1.14.16.2) Nicotine results in increased expression of TH protein increases expression
protein 17498763
D009538 9984 THOC1
HPR1
P84
P84N5
THO complex 1 Nicotine results in increased expression of THOC1 mRNA increases expression
mRNA 16949557
D009538 7076 TIMP1
CLGI
EPA
EPO
HCI
TIMP
TIMP metallopeptidase inhibitor 1 Nicotine affects the expression of TIMP1 mRNA affects expression
mRNA 18986645
D009538 7076 TIMP1
CLGI
EPA
EPO
HCI
TIMP
TIMP metallopeptidase inhibitor 1 [Nicotine co-treated with lipopolysaccharide, E. coli 026-B6] affects the expression of TIMP1 mRNA affects cotreatment
/ affects expression
mRNA 18986645
D009538 7078 TIMP3
HSMRK222
K222
K222TA2
SFD
TIMP metallopeptidase inhibitor 3 Nicotine affects the expression of TIMP3 mRNA affects expression
mRNA 18986645
D009538 7078 TIMP3
HSMRK222
K222
K222TA2
SFD
TIMP metallopeptidase inhibitor 3 [Nicotine co-treated with lipopolysaccharide, E. coli 026-B6] affects the expression of TIMP3 mRNA affects cotreatment
/ affects expression
mRNA 18986645
D009538 7079 TIMP4
TIMP metallopeptidase inhibitor 4 Nicotine affects the expression of TIMP4 mRNA affects expression
mRNA 18986645
D009538 7079 TIMP4
TIMP metallopeptidase inhibitor 4 [Nicotine co-treated with lipopolysaccharide, E. coli 026-B6] affects the expression of TIMP4 mRNA affects cotreatment
/ affects expression
mRNA 18986645
D009538 7082 TJP1
ZO-1
tight junction protein 1 Nicotine results in decreased expression of TJP1 protein decreases expression
protein 18844224
D009538 440026 TMEM41B
transmembrane protein 41B Nicotine results in increased expression of TMEM41B mRNA increases expression
mRNA 16949557
D009538 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Bungarotoxins inhibits the reaction [Nicotine inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF mRNA]] decreases reaction
/ increases secretion
mRNA 21606497
D009538 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor methyllycaconitine inhibits the reaction [Nicotine inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF mRNA]] decreases reaction
/ increases secretion
mRNA 21606497
D009538 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Nicotine inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein] decreases reaction
/ increases secretion
protein 21606497
D009538 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Nicotine results in increased degradation of TNF mRNA increases degradation
mRNA 21606497
D009538 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor ZFP36 mRNA affects the reaction [Nicotine inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]] affects reaction
/ decreases reaction
/ increases secretion
protein 21606497
D009538 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor ZFP36 mRNA affects the reaction [Nicotine results in increased degradation of TNF mRNA] affects reaction
/ increases degradation
mRNA 21606497
D009538 7132 TNFRSF1A
CD120a
FPF
MS5
TBP1
TNF-R
TNF-R-I
TNF-R55
TNFAR
TNFR1
TNFR1-d2
TNFR55
TNFR60
p55
p55-R
p60
tumor necrosis factor receptor superfamily, member 1A Nicotine results in decreased expression of TNFRSF1A mRNA decreases expression
mRNA 18247414
D009538 11073 TOPBP1
TOP2BP1
topoisomerase (DNA) II binding protein 1 Nicotine results in increased expression of TOPBP1 mRNA increases expression
mRNA 16949557
D009538 7157 TP53
BCC7
LFS1
P53
TRP53
tumor protein p53 4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide inhibits the reaction [Nicotine results in decreased expression of TP53 protein] decreases expression
/ decreases reaction
protein 18805435
D009538 7157 TP53
BCC7
LFS1
P53
TRP53
tumor protein p53 Nicotine inhibits the reaction [Cisplatin results in increased expression of TP53 protein] decreases reaction
/ increases expression
protein 16601104
D009538 7157 TP53
BCC7
LFS1
P53
TRP53
tumor protein p53 Nicotine inhibits the reaction [gemcitabine results in increased expression of TP53 protein] decreases reaction
/ increases expression
protein 16601104
D009538 7157 TP53
BCC7
LFS1
P53
TRP53
tumor protein p53 Nicotine inhibits the reaction [Paclitaxel results in increased expression of TP53 protein] decreases reaction
/ increases expression
protein 16601104
D009538 7157 TP53
BCC7
LFS1
P53
TRP53
tumor protein p53 Nicotine results in decreased expression of TP53 mRNA decreases expression
mRNA 18247414
D009538 7157 TP53
BCC7
LFS1
P53
TRP53
tumor protein p53 Nicotine results in decreased expression of TP53 protein decreases expression
protein 16011614
18805435
19139119
D009538 7157 TP53
BCC7
LFS1
P53
TRP53
tumor protein p53 Nicotine results in increased expression of TP53 protein increases expression
protein 20727180
D009538 7157 TP53
BCC7
LFS1
P53
TRP53
tumor protein p53 rosiglitazone inhibits the reaction [Nicotine results in decreased expression of TP53 protein] decreases expression
/ decreases reaction
protein 19139119
D009538 7157 TP53
BCC7
LFS1
P53
TRP53
tumor protein p53 TP53 protein affects the reaction [Nicotine results in increased phosphorylation of MAPK1 protein] affects reaction
/ increases phosphorylation
protein 20727180
D009538 7157 TP53
BCC7
LFS1
P53
TRP53
tumor protein p53 TP53 protein affects the reaction [Nicotine results in increased phosphorylation of MAPK3 protein] affects reaction
/ increases phosphorylation
protein 20727180
D009538 7157 TP53
BCC7
LFS1
P53
TRP53
tumor protein p53 TP53 protein affects the reaction [Nicotine results in increased phosphorylation of MAPK8 protein] affects reaction
/ increases phosphorylation
protein 20727180
D009538 7175 TPR
translocated promoter region, nuclear basket protein Nicotine results in increased expression of TPR mRNA increases expression
mRNA 16949557
D009538 29896 TRA2A
AWMS1
HSU53209
transformer 2 alpha homolog (Drosophila) Nicotine results in increased expression of TRA2A mRNA increases expression
mRNA 16949557
D009538 28951 TRIB2
C5FW
GS3955
TRB2
tribbles pseudokinase 2 Nicotine results in increased expression of TRIB2 mRNA increases expression
mRNA 16949557
D009538 9321 TRIP11
ACG1A
CEV14
GMAP-210
TRIP-11
TRIP230
thyroid hormone receptor interactor 11 Nicotine results in increased expression of TRIP11 mRNA increases expression
mRNA 16949557
D009538 7253 TSHR
CHNG1
LGR3
hTSHR-I
thyroid stimulating hormone receptor Nicotine results in increased expression of TSHR mRNA increases expression
mRNA 18247414
D009538 7277 TUBA4A
H2-ALPHA
TUBA1
tubulin, alpha 4a Nicotine results in decreased expression of TUBA4A mRNA decreases expression
mRNA 16949557
D009538 203068 TUBB
M40
OK/SW-cl.56
TUBB1
TUBB5
tubulin, beta class I Nicotine results in decreased expression of TUBB mRNA decreases expression
mRNA 16949557
D009538 7291 TWIST1
ACS3
BPES2
BPES3
CRS1
SCS
TWIST
bHLHa38
twist family bHLH transcription factor 1 Nicotine results in increased expression of TWIST1 mRNA increases expression
mRNA 23219715
D009538 10190 TXNDC9
APACD
PHLP3
thioredoxin domain containing 9 Nicotine results in increased expression of TXNDC9 mRNA increases expression
mRNA 16949557
D009538 23350 U2SURP
SR140
fSAPa
U2 snRNP-associated SURP domain containing Nicotine results in increased expression of U2SURP mRNA increases expression
mRNA 16949557
D009538 10054 UBA2
ARX
SAE2
ubiquitin-like modifier activating enzyme 2 Nicotine results in increased expression of UBA2 protein increases expression
protein 21554491
D009538 10054 UBA2
ARX
SAE2
ubiquitin-like modifier activating enzyme 2 [Nicotine results in increased expression of UBA2 protein] which results in increased sumoylation of EEF2 protein increases expression
/ increases sumoylation
protein 21554491
D009538 11065 UBE2C
UBCH10
dJ447F3.2
ubiquitin-conjugating enzyme E2C (EC:6.3.2.19) Nicotine results in decreased expression of UBE2C mRNA decreases expression
mRNA 16949557
D009538 11065 UBE2C
UBCH10
dJ447F3.2
ubiquitin-conjugating enzyme E2C (EC:6.3.2.19) Tubocurarine inhibits the reaction [Nicotine results in decreased expression of UBE2C mRNA] decreases expression
/ decreases reaction
mRNA 16949557
D009538 7329 UBE2I
C358B7.1
P18
UBC9
ubiquitin-conjugating enzyme E2I (EC:6.3.2.19) Nicotine results in decreased expression of UBE2I mRNA decreases expression
mRNA 18247414
D009538 7337 UBE3A
ANCR
AS
E6-AP
EPVE6AP
HPVE6A
ubiquitin protein ligase E3A (EC:6.3.2.19) Mecamylamine inhibits the reaction [Nicotine results in decreased expression of UBE3A mRNA] decreases expression
/ decreases reaction
mRNA 12588870
D009538 7337 UBE3A
ANCR
AS
E6-AP
EPVE6AP
HPVE6A
ubiquitin protein ligase E3A (EC:6.3.2.19) Nicotine inhibits the reaction [alpha-cobratoxin results in decreased expression of UBE3A mRNA] decreases expression
/ decreases reaction
mRNA 12588870
D009538 7337 UBE3A
ANCR
AS
E6-AP
EPVE6AP
HPVE6A
ubiquitin protein ligase E3A (EC:6.3.2.19) Nicotine results in decreased expression of UBE3A mRNA decreases expression
mRNA 12588870
D009538 7337 UBE3A
ANCR
AS
E6-AP
EPVE6AP
HPVE6A
ubiquitin protein ligase E3A (EC:6.3.2.19) Tubocurarine inhibits the reaction [Nicotine results in decreased expression of UBE3A mRNA] decreases expression
/ decreases reaction
mRNA 12588870
D009538 51569 UFM1
BM-002
C13orf20
ubiquitin-fold modifier 1 Nicotine results in increased expression of UFM1 mRNA increases expression
mRNA 16949557
D009538 7360 UGP2
UDPG
UDPGP
UDPGP2
UGP1
UGPP1
UGPP2
pHC379
UDP-glucose pyrophosphorylase 2 (EC:2.7.7.9) Nicotine results in increased expression of UGP2 mRNA increases expression
mRNA 18247414
D009538 54659 UGT1A3
UDPGT
UDPGT_1-3
UGT-1C
UGT1-03
UGT1.3
UGT1C
UDP glucuronosyltransferase 1 family, polypeptide A3 (EC:2.4.1.17) UGT1A3 protein results in increased glucuronidation of Nicotine increases glucuronidation
protein 14570768
D009538 54657 UGT1A4
HUG-BR2
UDPGT
UDPGT_1-4
UGT-1D
UGT1-04
UGT1.4
UGT1D
UDP glucuronosyltransferase 1 family, polypeptide A4 (EC:2.4.1.17) UGT1A4 protein results in increased glucuronidation of Nicotine increases glucuronidation
protein 14570768
16141602
D009538 54600 UGT1A9
HLUGP4
LUGP4
UDPGT
UDPGT_1-9
UGT-1I
UGT1-09
UGT1-9
UGT1.9
UGT1AI
UGT1I
UDP glucuronosyltransferase 1 family, polypeptide A9 (EC:2.4.1.17) UGT1A9 protein results in increased glucuronidation of Nicotine increases glucuronidation
protein 14570768
16141602
D009538 9094 UNC119
HRG4
POC7
POC7A
unc-119 homolog (C. elegans) Nicotine results in decreased expression of UNC119 mRNA decreases expression
mRNA 16949557
D009538 7386 UQCRFS1
RIP1
RIS1
RISP
UQCR5
ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 (EC:1.10.2.2) Nicotine results in decreased expression of UQCRFS1 mRNA decreases expression
mRNA 18247414
D009538 7412 VCAM1
CD106
INCAM-100
vascular cell adhesion molecule 1 Nicotine results in increased expression of VCAM1 mRNA increases expression
mRNA 11166759
D009538 7422 VEGFA
MVCD1
VEGF
VPF
vascular endothelial growth factor A Nicotine results in increased expression of VEGFA protein increases expression
protein 14569062
20457658
D009538 7431 VIM
CTRCT30
vimentin Nicotine results in decreased expression of VIM mRNA decreases expression
mRNA 18247414
D009538 7431 VIM
CTRCT30
vimentin Nicotine results in increased expression of VIM mRNA increases expression
mRNA 23219715
D009538 7431 VIM
CTRCT30
vimentin Nicotine results in increased expression of VIM protein increases expression
protein 18844224
D009538 7450 VWF
F8VWF
VWD
von Willebrand factor Nicotine results in increased expression of VWF mRNA increases expression
mRNA 11166759
D009538 331 XIAP
API3
BIRC4
IAP-3
ILP1
MIHA
XLP2
hIAP-3
hIAP3
X-linked inhibitor of apoptosis Curcumin inhibits the reaction [Nicotine results in increased expression of XIAP protein] decreases reaction
/ increases expression
protein 20727180
D009538 331 XIAP
API3
BIRC4
IAP-3
ILP1
MIHA
XLP2
hIAP-3
hIAP3
X-linked inhibitor of apoptosis Hexamethonium affects the reaction [Nicotine results in increased expression of XIAP protein] affects reaction
/ increases expression
protein 16601104
D009538 331 XIAP
API3
BIRC4
IAP-3
ILP1
MIHA
XLP2
hIAP-3
hIAP3
X-linked inhibitor of apoptosis Nicotine results in increased expression of XIAP mRNA increases expression
mRNA 21267677
D009538 331 XIAP
API3
BIRC4
IAP-3
ILP1
MIHA
XLP2
hIAP-3
hIAP3
X-linked inhibitor of apoptosis Nicotine results in increased expression of XIAP protein increases expression
protein 16601104
18676776
20727180
21267677
D009538 7503 XIST
DXS1089
DXS399E
LINC00001
NCRNA00001
SXI1
swd66
X inactive specific transcript (non-protein coding) Nicotine results in increased expression of XIST mRNA increases expression
mRNA 16949557
D009538 7525 YES1
HsT441
P61-YES
Yes
c-yes
v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1 (EC:2.7.10.2) Nicotine results in increased expression of YES1 mRNA increases expression
mRNA 16949557
D009538 23318 ZCCHC11
PAPD3
TUT4
zinc finger, CCHC domain containing 11 (EC:2.7.7.52) Nicotine results in increased expression of ZCCHC11 mRNA increases expression
mRNA 16949557
D009538 84240 ZCCHC9
PPP1R41
zinc finger, CCHC domain containing 9 Nicotine results in increased expression of ZCCHC9 mRNA increases expression
mRNA 16949557
D009538 6935 ZEB1
AREB6
BZP
DELTAEF1
FECD6
NIL2A
PPCD3
TCF8
ZFHEP
ZFHX1A
zinc finger E-box binding homeobox 1 Nicotine results in increased expression of ZEB1 mRNA increases expression
mRNA 16949557
D009538 7538 ZFP36
G0S24
GOS24
NUP475
RNF162A
TIS11
TTP
zfp-36
ZFP36 ring finger protein Bungarotoxins inhibits the reaction [[Nicotine co-treated with Lipopolysaccharides] results in increased expression of ZFP36 mRNA] affects cotreatment
/ decreases reaction
/ increases expression
mRNA 21606497
D009538 7538 ZFP36
G0S24
GOS24
NUP475
RNF162A
TIS11
TTP
zfp-36
ZFP36 ring finger protein methyllycaconitine inhibits the reaction [[Nicotine co-treated with Lipopolysaccharides] results in increased expression of ZFP36 mRNA] affects cotreatment
/ decreases reaction
/ increases expression
mRNA 21606497
D009538 7538 ZFP36
G0S24
GOS24
NUP475
RNF162A
TIS11
TTP
zfp-36
ZFP36 ring finger protein [Nicotine co-treated with Lipopolysaccharides] results in increased expression of ZFP36 mRNA affects cotreatment
/ increases expression
mRNA 21606497
D009538 7538 ZFP36
G0S24
GOS24
NUP475
RNF162A
TIS11
TTP
zfp-36
ZFP36 ring finger protein [Nicotine co-treated with Lipopolysaccharides] results in increased expression of ZFP36 protein affects cotreatment
/ increases expression
protein 21606497
D009538 7538 ZFP36
G0S24
GOS24
NUP475
RNF162A
TIS11
TTP
zfp-36
ZFP36 ring finger protein Nicotine promotes the reaction [STAT3 protein binds to ZFP36 promoter] affects binding
/ increases reaction
promoter 21606497
D009538 7538 ZFP36
G0S24
GOS24
NUP475
RNF162A
TIS11
TTP
zfp-36
ZFP36 ring finger protein Nicotine results in increased activity of ZFP36 promoter increases activity
promoter 21606497
D009538 7538 ZFP36
G0S24
GOS24
NUP475
RNF162A
TIS11
TTP
zfp-36
ZFP36 ring finger protein ZFP36 mRNA affects the reaction [Nicotine inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]] affects reaction
/ decreases reaction
/ increases secretion
mRNA 21606497
D009538 7538 ZFP36
G0S24
GOS24
NUP475
RNF162A
TIS11
TTP
zfp-36
ZFP36 ring finger protein ZFP36 mRNA affects the reaction [Nicotine results in increased degradation of TNF mRNA] affects reaction
/ increases degradation
mRNA 21606497
D009538 51663 ZFR
ZFR1
zinc finger RNA binding protein alpha-cobratoxin inhibits the reaction [Nicotine results in decreased expression of ZFR mRNA] decreases expression
/ decreases reaction
mRNA 12588870
D009538 51663 ZFR
ZFR1
zinc finger RNA binding protein Mecamylamine inhibits the reaction [Nicotine results in decreased expression of ZFR mRNA] decreases expression
/ decreases reaction
mRNA 12588870
D009538 51663 ZFR
ZFR1
zinc finger RNA binding protein Nicotine results in decreased expression of ZFR mRNA decreases expression
mRNA 12588870
D009538 51663 ZFR
ZFR1
zinc finger RNA binding protein Tubocurarine inhibits the reaction [Nicotine results in decreased expression of ZFR mRNA] decreases expression
/ decreases reaction
mRNA 12588870
D009538 23613 ZMYND8
PRKCBP1
PRO2893
RACK7
zinc finger, MYND-type containing 8 Nicotine results in increased expression of ZMYND8 mRNA increases expression
mRNA 16949557
D009538 7705 ZNF146
OZF
zinc finger protein 146 Nicotine results in increased expression of ZNF146 mRNA increases expression
mRNA 16949557
D009538 100129482 ZNF37BP
KOX21
ZNF37B
zinc finger protein 37B, pseudogene Nicotine results in increased expression of ZNF37BP mRNA increases expression
mRNA 16949557
D009538 90333 ZNF468
zinc finger protein 468 Nicotine results in increased expression of ZNF468 mRNA increases expression
mRNA 16949557
D009538 100289635 ZNF605
zinc finger protein 605 Nicotine results in increased expression of ZNF605 mRNA increases expression
mRNA 16949557
D009538 100129842 ZNF737
ZNF102
zinc finger protein 737 Nicotine results in increased expression of ZNF737 mRNA increases expression
mRNA 16949557

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (72)

OMIM preferred title UniProt
#100100 Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism P20309
#103780 Alcohol dependence P08172
P14416
P31645
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#614373 Amyotrophic lateral sclerosis 16, juvenile; als16 Q99720
#602025 Body mass index quantitative trait locus 9; bmiq9 P41968
#300615 Brunner syndrome P21397
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#212140 Carnitine deficiency, systemic primary; cdsp O76082
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#114500 Colorectal cancer; crc P84022
#162800 Cyclic neutropenia P08246
#612522 Diabetes mellitus, insulin-dependent, 22; iddm22 P51681
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#237500 Dubin-johnson syndrome; djs Q92887
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#600513 Epilepsy, nocturnal frontal lobe, 1; enfl1 P43681
#605375 Epilepsy, nocturnal frontal lobe, 3; enfl3 P17787
#610353 Epilepsy, nocturnal frontal lobe, 4; enfl4 Q15822
#615040 Episodic pain syndrome, familial, 1; feps1 O75762
#615363 Estrogen resistance; estrr P03372
#600274 Frontotemporal dementia; ftd P10636
#613659 Gastric cancer P04626
#137215 Gastric cancer, hereditary diffuse; hdgc P04626
#231095 Ghosal hematodiaphyseal dysplasia; ghdd P24557
#137800 Glioma susceptibility 1; glm1 P04626
#610140 Heart-hand syndrome, slovenian type P02545
#609423 Human immunodeficiency virus type 1, susceptibility to P41597
P51681
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#237450 Hyperbilirubinemia, rotor type; hblrr Q9NPD5
Q9Y6L6
#603932 Intervertebral disc disease; idd P14780
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#613688 Long qt syndrome 2; lqt2 Q12809
#211980 Lung cancer P00533
P04626
#608516 Major depressive disorder; mdd P08172
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
%300852 Mental retardation, x-linked 88; mrx88 P50052
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#265000 Multiple pterygium syndrome, escobar variant; evmps P07510
#253290 Multiple pterygium syndrome, lethal type; lmps P02708
P07510
Q07001
#126200 Multiple sclerosis, susceptibility to; ms P08575
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#608931 Myasthenic syndrome, congenital, associated with acetylcholine receptor deficiency P11230
#608930 Myasthenic syndrome, congenital, fast-channel P02708
Q07001
#601462 Myasthenic syndrome, congenital, slow-channel; sccms P02708
P11230
Q07001
#159900 Myoclonic dystonia P14416
#202700 Neutropenia, severe congenital, 1, autosomal dominant; scn1 P08246
#601665 Obesity P32245
#164230 Obsessive-compulsive disorder; ocd P31645
#604715 Orthostatic intolerance P23975
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#167000 Ovarian cancer P04626
#260540 Parkinson-dementia syndrome P10636
#613135 Parkinsonism-dystonia, infantile; pkdys Q01959
#172700 Pick disease of brain P10636
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#607276 Resting heart rate, variation in P08588
#275210 Restrictive dermopathy, lethal P02545
#180300 Rheumatoid arthritis; ra Q9H015
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#608971 Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive P08575
#609620 Short qt syndrome 1; sqt1 Q12809
#612052 Smoking as a quantitative trait locus 3; sqtl3 P30532
P32297
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#190300 Tremor, hereditary essential, 1; etm1 P35462
#610379 West nile virus, susceptibility to P51681
#112100 Yt blood group antigen P22303

KEGG DISEASE (55)

KEGG disease name UniProt
H00286 Crohn's disease O76082 (related)
Q9H015 (related)
H00525 Disorders of fatty-acid oxidation O76082 (related)
H00016 Oral cancer P00533 (related)
P00533 (marker)
H00017 Esophageal cancer P00533 (related)
P35354 (related)
H00018 Gastric cancer P00533 (related)
P04626 (related)
H00022 Bladder cancer P00533 (related)
P04626 (related)
H00028 Choriocarcinoma P00533 (related)
P03956 (related)
P04626 (related)
H00030 Cervical cancer P00533 (related)
P04626 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00770 Congenital myasthenic syndrome P02708 (related)
P11230 (related)
Q07001 (related)
H00986 Multiple pterygium syndrome P02708 (related)
P07510 (related)
Q07001 (related)
H00026 Endometrial Cancer P03372 (marker)
P04626 (related)
Q92731 (marker)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00019 Pancreatic cancer P04626 (related)
H00027 Ovarian cancer P04626 (related)
H00031 Breast cancer P04626 (related)
P04626 (marker)
H00046 Cholangiocarcinoma P04626 (related)
P35354 (related)
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
H00079 Asthma P07550 (related)
H00100 Neutropenic disorders P08246 (related)
H00091 T-B+Severe combined immunodeficiencies (SCIDs) P08575 (related)
H00036 Osteosarcoma P08684 (marker)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
Q13148 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H01205 Coumarin resistance P11712 (related)
H00025 Penile cancer P14780 (related)
P35354 (related)
H00479 Metaphyseal dysplasias P14780 (related)
H00807 Autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) P17787 (related)
P43681 (related)
Q15822 (related)
H00548 Brunner syndrome P21397 (related)
H01031 Orthostatic intolerance (OI) P23975 (related)
H00490 Diaphyseal dysplasia with anemia (Ghosal) P24557 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00480 Non-syndromic X-linked mental retardation P50052 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00720 Long QT syndrome Q12809 (related)
H00725 Short QT syndrome Q12809 (related)
H00208 Hyperbilirubinemia Q92887 (related)
H00063 Spinocerebellar ataxia (SCA) Q9NUW8 (related)

Diseases related to CTD interactions

191 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D015746 D009538 Abdominal Pain marker/mechanism
9179092
D000014 D009538 Abnormalities, Drug-Induced marker/mechanism
16193507
D058186 D009538 Acute Kidney Injury marker/mechanism
21511693
D000405 D009538 Akinetic Mutism therapeutic
19455735
D000437 D009538 Alcoholism marker/mechanism
17067804
D000544 D009538 Alzheimer Disease therapeutic
16627626
17135361
D000647 D009538 Amnesia therapeutic
8968367
16174677
16893575
17565710
18316071
21130846
D019969 D009538 Amphetamine-Related Disorders marker/mechanism
therapeutic
15542755
16820538
19733448
D017542 D009538 Aneurysm, Ruptured marker/mechanism
12764233
D000860 D009538 Anoxia marker/mechanism
14980338
D001008 D009538 Anxiety Disorders therapeutic
15991002
D001014 D009538 Aortic Aneurysm marker/mechanism
9179092
9687945
D001018 D009538 Aortic Diseases marker/mechanism
15025861
20050989
D001049 D009538 Apnea marker/mechanism
2371153
15477168
D001145 D009538 Arrhythmias, Cardiac marker/mechanism
10973847
19559087
19728315
D001161 D009538 Arteriosclerosis marker/mechanism
812508
D001168 D009538 Arthritis marker/mechanism
8746358
D001176 D009538 Arthrogryposis marker/mechanism
8073369
D001259 D009538 Ataxia marker/mechanism
19281835
23219611
D050197 D009538 Atherosclerosis marker/mechanism
9245658
9666528
10509436
16254210
19492997
19559087
20050989
D001281 D009538 Atrial Fibrillation marker/mechanism
3945010
7703770
12713677
D054537 D009538 Atrioventricular Block marker/mechanism
1259687
D001289 D009538 Attention Deficit Disorder with Hyperactivity marker/mechanism
therapeutic
16497598
16554741
18074112
19628140
D001308 D009538 Auditory Perceptual Disorders therapeutic
10578459
D001714 D009538 Bipolar Disorder marker/mechanism
19628140
D001919 D009538 Bradycardia marker/mechanism
652837
1259687
3712280
7027322
7296375
7743629
7803426
7925598
9204607
D001927 D009538 Brain Diseases marker/mechanism
10837795
14980338
D001929 D009538 Brain Edema marker/mechanism
20324
19782326
D001930 D009538 Brain Injuries therapeutic
18803299
D001943 D009538 Breast Neoplasms marker/mechanism
therapeutic
18844224
21371177
D002114 D009538 Calcinosis marker/mechanism
16378124
D002289 D009538 Carcinoma, Non-Small-Cell Lung marker/mechanism
18844224
D002294 D009538 Carcinoma, Squamous Cell marker/mechanism
18450646
D005117 D009538 Cardiac Complexes, Premature marker/mechanism
1259687
D009202 D009538 Cardiomyopathies marker/mechanism
19559087
D002318 D009538 Cardiovascular Diseases marker/mechanism
8124816
8129055
9245658
16311929
18676298
19559087
D002375 D009538 Catalepsy marker/mechanism
therapeutic
987911
1775613
7902980
8265684
10958255
11100936
11900788
D002543 D009538 Cerebral Hemorrhage marker/mechanism
7658896
8073369
D002561 D009538 Cerebrovascular Disorders marker/mechanism
8100951
D018290 D009538 Cervical Intraepithelial Neoplasia marker/mechanism
20190800
D002637 D009538 Chest Pain marker/mechanism
9179092
9687945
D019970 D009538 Cocaine-Related Disorders marker/mechanism
9543646
12110995
14975690
D003072 D009538 Cognition Disorders marker/mechanism
therapeutic
9336330
18662793
20060465
20441798
D003093 D009538 Colitis, Ulcerative therapeutic
9305473
9354194
9895047
15976189
D003110 D009538 Colonic Neoplasms marker/mechanism
14569062
17369603
D019955 D009538 Conduct Disorder marker/mechanism
19628140
D003251 D009538 Constriction, Pathologic marker/mechanism
8522735
D003324 D009538 Coronary Artery Disease marker/mechanism
11166759
D003329 D009538 Coronary Vasospasm marker/mechanism
19559087
D003490 D009538 Cyanosis marker/mechanism
1259687
D003693 D009538 Delirium therapeutic
9737096
12325491
D003866 D009538 Depressive Disorder marker/mechanism
therapeutic
8743774
12691787
19043277
21297339
D003865 D009538 Depressive Disorder, Major marker/mechanism
therapeutic
8854376
9746444
16554741
D003872 D009538 Dermatitis marker/mechanism
9565740
D003924 D009538 Diabetes Mellitus, Type 2 marker/mechanism
20363831
D003928 D009538 Diabetic Nephropathies marker/mechanism
20685820
D003967 D009538 Diarrhea marker/mechanism
2371153
D004244 D009538 Dizziness marker/mechanism
3401862
8409878
9305473
10392670
14520160
17990061
D056486 D009538 Drug-Induced Liver Injury marker/mechanism
8884888
D064420 D009538 Drug-Related Side Effects and Adverse Reactions marker/mechanism
14980338
D004409 D009538 Dyskinesia, Drug-Induced marker/mechanism
therapeutic
8570751
17960553
18650244
20200117
21232546
D004421 D009538 Dystonia marker/mechanism
19404753
D020821 D009538 Dystonic Disorders marker/mechanism
17881519
D001068 D009538 Eating Disorders marker/mechanism
9746444
D004487 D009538 Edema marker/mechanism
12575837
D004802 D009538 Eosinophilia marker/mechanism
12575837
D007172 D009538 Erectile Dysfunction marker/mechanism
17971108
D004890 D009538 Erythema marker/mechanism
8746358
D005076 D009538 Exanthema marker/mechanism
8028537
10392670
D005234 D009538 Fatty Liver marker/mechanism
8884888
D005317 D009538 Fetal Growth Retardation marker/mechanism
22265867
D005334 D009538 Fever marker/mechanism
therapeutic
8746358
15138183
D005921 D009538 Glomerulonephritis marker/mechanism
20685820
D044882 D009538 Glucose Metabolism Disorders marker/mechanism
18852877
D006261 D009538 Headache marker/mechanism
8130921
8409878
16330293
D006258 D009538 Head and Neck Neoplasms marker/mechanism
11592233
D006323 D009538 Heart Arrest marker/mechanism
1259687
D006606 D009538 Hiccup marker/mechanism
16330293
D006930 D009538 Hyperalgesia marker/mechanism
16915382
D006940 D009538 Hyperemia marker/mechanism
15500638
D006948 D009538 Hyperkinesis marker/mechanism
1833784
3220106
7659769
7870924
7902980
7990972
8741744
9264082
9278937
10432212
10475164
10945867
11605085
12479946
12691787
12845407
15680187
16251992
17030062
19347958
19379770
19571743
D006973 D009538 Hypertension marker/mechanism
therapeutic
2022074
5608715
6638819
7803426
9204607
9446711
9862770
10781917
11465642
17127264
17452284
19559087
19637760
20363831
D006976 D009538 Hypertension, Pulmonary marker/mechanism
7399993
16499655
D006984 D009538 Hypertrophy marker/mechanism
20685820
D006985 D009538 Hyperventilation marker/mechanism
3976905
D018476 D009538 Hypokinesia marker/mechanism
12234654
D007022 D009538 Hypotension marker/mechanism
7027322
D007035 D009538 Hypothermia marker/mechanism
652837
7913497
14982698
15099917
17951610
19371589
D007246 D009538 Infertility marker/mechanism
20363831
D007249 D009538 Inflammation marker/mechanism
therapeutic
18068289
19586999
D007333 D009538 Insulin Resistance marker/mechanism
17906372
D055959 D009538 Intervertebral Disc Degeneration marker/mechanism
11484105
D002542 D009538 Intracranial Embolism and Thrombosis marker/mechanism
245329
D007511 D009538 Ischemia marker/mechanism
19559087
21511693
D007805 D009538 Language Development Disorders marker/mechanism
8001318
D007859 D009538 Learning Disorders marker/mechanism
22119111
D008107 D009538 Liver Diseases marker/mechanism
15925865
D008133 D009538 Long QT Syndrome marker/mechanism
12766260
D008171 D009538 Lung Diseases marker/mechanism
15925865
17868207
21378373
D008175 D009538 Lung Neoplasms marker/mechanism
16598845
17459420
18676776
19903766
20727180
D008545 D009538 Melanoma marker/mechanism
15029439
D008569 D009538 Memory Disorders therapeutic
8968367
D028361 D009538 Mitochondrial Diseases marker/mechanism
20960268
D009041 D009538 Motion Sickness marker/mechanism
17990061
D009069 D009538 Movement Disorders therapeutic
18803299
D020267 D009538 MPTP Poisoning therapeutic
9503263
20230807
D009133 D009538 Muscular Atrophy marker/mechanism
18694773
D009203 D009538 Myocardial Infarction marker/mechanism
2615289
7703770
7781384
8131771
9403280
11528015
D015428 D009538 Myocardial Reperfusion Injury marker/mechanism
8124816
D009207 D009538 Myoclonus marker/mechanism
1736170
D009325 D009538 Nausea marker/mechanism
3401862
8409878
9305473
9565740
9746444
14520160
16330293
17990061
D009336 D009538 Necrosis marker/mechanism
3594060
8884888
10880836
11484105
15925865
19673871
D009361 D009538 Neoplasm Invasiveness marker/mechanism
18844224
20061081
22261521
D009362 D009538 Neoplasm Metastasis marker/mechanism
20061081
D009369 D009538 Neoplasms marker/mechanism
8370474
11701223
16365874
D009374 D009538 Neoplasms, Experimental marker/mechanism
20457658
D009389 D009538 Neovascularization, Pathologic marker/mechanism
14569062
15000345
16365874
17369603
18571475
19492997
20050989
20457658
D009410 D009538 Nerve Degeneration marker/mechanism
11430869
11578609
D009422 D009538 Nervous System Diseases therapeutic
9832142
D009436 D009538 Neural Tube Defects marker/mechanism
16193507
D019954 D009538 Neurobehavioral Manifestations marker/mechanism
20363831
D019636 D009538 Neurodegenerative Diseases therapeutic
12377264
14757701
D054081 D009538 Neuronal Migration Disorders marker/mechanism
18694773
D020258 D009538 Neurotoxicity Syndromes marker/mechanism
15039772
D009669 D009538 Nose Neoplasms marker/mechanism
20338106
D009759 D009538 Nystagmus, Pathologic marker/mechanism
2221850
11094116
11338195
17990061
18417364
D009765 D009538 Obesity marker/mechanism
20363831
D009845 D009538 Oligospermia marker/mechanism
20498001
D010146 D009538 Pain therapeutic
3739811
6496202
7870924
10336510
10834088
12384171
15689546
17951610
20232057
D010182 D009538 Pancreatic Diseases marker/mechanism
18852877
D010190 D009538 Pancreatic Neoplasms marker/mechanism
18824948
D016584 D009538 Panic Disorder marker/mechanism
3777262
D030361 D009538 Papillomavirus Infections marker/mechanism
15029439
D010243 D009538 Paralysis marker/mechanism
18694773
19121331
D010291 D009538 Paresis marker/mechanism
1736170
D010302 D009538 Parkinson Disease, Secondary therapeutic
8570751
D010510 D009538 Periodontal Diseases marker/mechanism
12200972
D010523 D009538 Peripheral Nervous System Diseases marker/mechanism
16915382
D016491 D009538 Peripheral Vascular Diseases marker/mechanism
19559087
D011041 D009538 Poisoning marker/mechanism
2371153
5644266
D011086 D009538 Polycythemia marker/mechanism
2615289
D011183 D009538 Postoperative Complications marker/mechanism
8522735
D011297 D009538 Prenatal Exposure Delayed Effects marker/mechanism
2856807
8001318
9181671
9264082
12691787
15039772
15477168
15980792
16554741
16690037
17906372
18272879
18647709
18662793
19619640
19628140
19728315
20060465
20426880
21378373
21633116
D003668 D009538 Pressure Ulcer marker/mechanism
19673871
D011507 D009538 Proteinuria marker/mechanism
20685820
D011537 D009538 Pruritus marker/mechanism
8130921
D011605 D009538 Psychoses, Substance-Induced therapeutic
11331147
D011618 D009538 Psychotic Disorders marker/mechanism
17383738
D011654 D009538 Pulmonary Edema marker/mechanism
19782326
D011693 D009538 Purpura marker/mechanism
8746358
D012021 D009538 Reflex, Abnormal marker/mechanism
1736170
D051436 D009538 Renal Insufficiency, Chronic marker/mechanism
21511693
D015427 D009538 Reperfusion Injury marker/mechanism
19673871
21511693
D012120 D009538 Respiration Disorders marker/mechanism
9565740
D012131 D009538 Respiratory Insufficiency marker/mechanism
1179485
D015619 D009538 Respiratory System Abnormalities marker/mechanism
20363831
D012164 D009538 Retinal Diseases marker/mechanism
20448088
D012640 D009538 Seizures marker/mechanism
therapeutic
1803
402662
450947
1179485
1434140
2253697
2371153
2787643
2813485
2859023
2866286
3133700
3174752
3355671
3362916
3362931
3435639
3737641
3795045
3999475
4010471
4390479
5298310
6489864
6502513
6843794
7073000
7913497
7971729
8205140
8739548
8937624
9037516
9096244
9231353
9495872
9877318
10072918
10336510
10479471
10565853
10734154
10834088
10942032
11334243
11518099
11712662
11834293
11854451
11893908
12068243
12198388
12679146
12829730
14996991
15204062
15275829
15857624
16256958
16339034
16769170
17098430
17418694
17456735
17873105
17881519
17951610
17997037
18767395
19145339
20694554
D012798 D009538 Sialorrhea marker/mechanism
9746444
D012848 D009538 Sinoatrial Block marker/mechanism
1259687
D012878 D009538 Skin Neoplasms marker/mechanism
15029439
D012893 D009538 Sleep Disorders marker/mechanism
8028537
9305473
9565740
12228730
D007319 D009538 Sleep Initiation and Maintenance Disorders marker/mechanism
9746444
20182857
D055752 D009538 Small Cell Lung Carcinoma marker/mechanism
20457658
D013035 D009538 Spasm marker/mechanism
539451
1259687
D016137 D009538 Spina Bifida Cystica marker/mechanism
22473653
D013117 D009538 Spinal Cord Compression therapeutic
15135227
D019956 D009538 Stereotypic Movement Disorder marker/mechanism
7902980
D013274 D009538 Stomach Neoplasms marker/mechanism
17003101
18805435
20061081
D013276 D009538 Stomach Ulcer marker/mechanism
19088804
D020521 D009538 Stroke marker/mechanism
8193434
D013345 D009538 Subarachnoid Hemorrhage marker/mechanism
12764233
D019966 D009538 Substance-Related Disorders marker/mechanism
12434259
16554741
21113126
D013375 D009538 Substance Withdrawal Syndrome marker/mechanism
therapeutic
2486194
2594893
2641020
4091074
8028537
8109663
8743774
8956374
8958597
9293047
9521491
9562753
9737096
11072453
11267637
11271403
12325491
12384171
12628619
12646326
12719964
12851662
12858318
12860478
13129839
15542752
15922326
16292514
16366758
16382193
17884348
18184829
19028516
19145226
19371589
19455735
19644040
20056851
20182857
20232057
20441798
20673878
21057436
21071625
21324836
D013398 D009538 Sudden Infant Death marker/mechanism
9181671
15980792
D013610 D009538 Tachycardia marker/mechanism
1259687
7925598
18567834
D013919 D009538 Thromboangiitis Obliterans marker/mechanism
12474585
D013927 D009538 Thrombosis marker/mechanism
therapeutic
6638819
7055868
7373157
17384961
D020323 D009538 Tics therapeutic
15774505
188890 D009538 TOBACCO ADDICTION, SUSCEPTIBILITY TO marker/mechanism
therapeutic
11259349
16720336
16785264
D014029 D009538 Tobacco Use Disorder marker/mechanism
therapeutic
519268
2641020
8028537
8109663
8130921
8409878
8743774
8958597
9308759
9784902
9862770
10497441
12610193
12628619
12646326
12860478
12911050
14656552
14684476
15542752
15735609
16366758
17383738
17884348
17979512
18041664
18071902
18184829
18305452
18629735
18852877
19145226
20673878
21324836
22424115
D005879 D009538 Tourette Syndrome therapeutic
15774505
D014133 D009538 Tracheal Diseases marker/mechanism
12575837
D014202 D009538 Tremor marker/mechanism
450947
599971
980220
1259687
2263651
2576144
2866286
3378602
5157720
5298310
6258692
6687130
7902979
7990972
9151294
9278937
9305473
9369366
9548994
11070179
23219611
D001745 D009538 Urinary Bladder Diseases marker/mechanism
15025861
D014652 D009538 Vascular Diseases marker/mechanism
7424135
16378124
18951979
19910445
D014657 D009538 Vasculitis marker/mechanism
8746358
D018366 D009538 Vasculitis, Leukocytoclastic, Cutaneous marker/mechanism
8746358
D018879 D009538 Ventricular Premature Complexes marker/mechanism
4185489
D014839 D009538 Vomiting marker/mechanism
1259687
2371153
9565740
9746444
14520160
21827451
D015430 D009538 Weight Gain therapeutic
8956374