PCIDB

KNApSAcK Metabolite C00002063

Metabolite

KNApSAcK Entry

id C00002063
Name Picolinic acid
CAS RN 98-98-6
Standard InChI InChI=1S/C6H5NO2/c8-6(9)5-3-1-2-4-7-5/h1-4H,(H,8,9)
Standard InChI (Main Layer) InChI=1S/C6H5NO2/c8-6(9)5-3-1-2-4-7-5/h1-4H,(H,8,9)

Cluster

Phytochemical cluster No. 1
KCF-S cluster No. 3681

Link

ChEMBL

By standard InChI CHEMBL72628
By standard InChI Main Layer CHEMBL72628

KEGG

By LinkDB C10164

CTD

By CAS RN C030614

Species

Summary

Plant class

class name count

Family

family name count
Nectriaceae 1
Magnaporthaceae 1

List (2)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Fusarium lateritium 5523 Nectriaceae Fungi
Pyricularia oryzae 318829 Magnaporthaceae Fungi

Human Protein / Gene in interaction

16 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein CHEMBL72628 CHEMBL1738312 (1)
0 / 0
P09917 Arachidonate 5-lipoxygenase Oxidoreductase CHEMBL72628 CHEMBL1664429 (1)
0 / 0
P22894 Neutrophil collagenase M10A CHEMBL72628 CHEMBL1664434 (1)
0 / 0
P14780 Matrix metalloproteinase-9 M10A CHEMBL72628 CHEMBL1664435 (1)
2 / 2
P02545 Prelamin-A/C Unclassified protein CHEMBL72628 CHEMBL1614544 (1)
11 / 10
P39748 Flap endonuclease 1 Enzyme CHEMBL72628 CHEMBL1794486 (1)
0 / 0
O75496 Geminin Unclassified protein CHEMBL72628 CHEMBL2114843 (1) CHEMBL2114780 (1)
0 / 0
Q9NXG6 Transmembrane prolyl 4-hydroxylase Enzyme CHEMBL72628 CHEMBL765596 (1) CHEMBL844877 (1)
0 / 0
P03956 Interstitial collagenase M10A CHEMBL72628 CHEMBL1664431 (1)
0 / 1
Q9Y468 Lethal(3)malignant brain tumor-like protein 1 Unclassified protein CHEMBL72628 CHEMBL1614280 (1)
0 / 0
P08253 72 kDa type IV collagenase M10A CHEMBL72628 CHEMBL1664432 (1)
1 / 3
Q9UNA4 DNA polymerase iota Enzyme CHEMBL72628 CHEMBL1794483 (1)
0 / 0
O75164 Lysine-specific demethylase 4A Enzyme CHEMBL72628 CHEMBL1737991 (1)
0 / 0
Q7Z2H8 Proton-coupled amino acid transporter 1 Unclassified protein CHEMBL72628 CHEMBL1919336 (2)
0 / 0
P08254 Stromelysin-1 M10A CHEMBL72628 CHEMBL1664433 (1)
1 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme CHEMBL72628 CHEMBL1738442 (1)
0 / 0

CTD interaction (6)

compound gene gene name gene description interaction interaction type form reference
pmid
C030614 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) picolinic acid results in decreased activity of CASP3 protein decreases activity
protein 19853652
C030614 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) picolinic acid results in increased activity of CASP3 protein increases activity
protein 19853652
C030614 6347 CCL2
GDCF-2
HC11
HSMCR30
MCAF
MCP-1
MCP1
SCYA2
SMC-CF
chemokine (C-C motif) ligand 2 picolinic acid inhibits the reaction [Glucose results in increased secretion of CCL2 protein] decreases reaction
/ increases secretion
protein 17665966
C030614 3039 HBA1
CD31
HBH
hemoglobin, alpha 1 picolinic acid results in decreased glycation of HBA1 protein decreases glycation
protein 22944053
C030614 3569 IL6
BSF2
HGF
HSF
IFNB2
IL-6
interleukin 6 (interferon, beta 2) picolinic acid inhibits the reaction [Glucose results in increased secretion of IL6 protein] decreases reaction
/ increases secretion
protein 17665966
C030614 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 picolinic acid inhibits the reaction [Glucose results in increased secretion of IL8 protein] decreases reaction
/ increases secretion
protein 17665966

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (15)

OMIM preferred title UniProt
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#614466 Coronary heart disease, susceptibility to, 6; chds6 P08254
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#603932 Intervertebral disc disease; idd P14780
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#259600 Multicentric osteolysis, nodulosis, and arthropathy; mona P08253
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#275210 Restrictive dermopathy, lethal P02545

KEGG DISEASE (14)

KEGG disease name UniProt
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00028 Choriocarcinoma P03956 (related)
P08253 (related)
H00025 Penile cancer P08253 (related)
P14780 (related)
H00472 Torg-Winchester syndrome P08253 (related)
H00479 Metaphyseal dysplasias P14780 (related)

Diseases related to CTD interactions

6 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D058186 C030614 Acute Kidney Injury therapeutic
20817559
D000236 C030614 Adenoma marker/mechanism
20725156
D003921 C030614 Diabetes Mellitus, Experimental therapeutic
22287284
D006943 C030614 Hyperglycemia therapeutic
17496732
D007333 C030614 Insulin Resistance therapeutic
17496732
D059606 C030614 Polydipsia therapeutic
22287284