Species

KNApSAcK Entry

Organism name Pyricularia oryzae
Genus
Family
Kingdom

NCBI taxonomy

Entry

Linked NCBI taxonomy name Magnaporthe oryzae
Linked NCBI taxonomy ID 318829
Linked level species

Family

Family in NCBI taxonomy Magnaporthaceae
ID 81093

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Fungi
ID 4751

Plant class

Plant class
ID

Metabolite list (4)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00036496 External link 512 2-Hydroxyjuglone
CHEMBL1089486
C420979
No. 1047 No. 80
C00002063 External link 512 Picolinic acid
CHEMBL72628
C030614
16 / 15 / 14 5 / 6 No. 3681 No. 1
C00023717 External link 512 Pyriculariol
No. 4505
C00001554 External link 512 Tenuazonic acid
No. 8799

Human Protein / Gene in interactions

16 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00002063 0 / 0
P09917 Arachidonate 5-lipoxygenase Oxidoreductase C00002063 0 / 0
P22894 Neutrophil collagenase M10A C00002063 0 / 0
P14780 Matrix metalloproteinase-9 M10A C00002063 2 / 2
P02545 Prelamin-A/C Unclassified protein C00002063 11 / 10
P39748 Flap endonuclease 1 Enzyme C00002063 0 / 0
O75496 Geminin Unclassified protein C00002063 0 / 0
Q9NXG6 Transmembrane prolyl 4-hydroxylase Enzyme C00002063 0 / 0
P03956 Interstitial collagenase M10A C00002063 0 / 1
Q9Y468 Lethal(3)malignant brain tumor-like protein 1 Unclassified protein C00002063 0 / 0
P08253 72 kDa type IV collagenase M10A C00002063 1 / 3
Q9UNA4 DNA polymerase iota Enzyme C00002063 0 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00002063 0 / 0
Q7Z2H8 Proton-coupled amino acid transporter 1 Unclassified protein C00002063 0 / 0
P08254 Stromelysin-1 M10A C00002063 1 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00002063 0 / 0

5 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
836 CASP3, CPP32, CPP32B, SCA-1 caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) C00002063
6347 CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF chemokine (C-C motif) ligand 2 C00002063
3039 HBA1, CD31, HBH hemoglobin, alpha 1 C00002063
3569 IL6, BSF2, HGF, HSF, IFNB2, IL-6 interleukin 6 (interferon, beta 2) C00002063
3576 IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 interleukin 8 C00002063

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (15)

OMIM preferred title UniProt
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#614466 Coronary heart disease, susceptibility to, 6; chds6 P08254
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#603932 Intervertebral disc disease; idd P14780
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#259600 Multicentric osteolysis, nodulosis, and arthropathy; mona P08253
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#275210 Restrictive dermopathy, lethal P02545

KEGG DISEASE (14)

KEGG name UniProt
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00028 Choriocarcinoma P03956 (related)
P08253 (related)
H00025 Penile cancer P08253 (related)
P14780 (related)
H00472 Torg-Winchester syndrome P08253 (related)
H00479 Metaphyseal dysplasias P14780 (related)

Diseases related to CTD interactions

6 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D058186 Acute Kidney Injury C00002063
D000236 Adenoma C00002063
D003921 Diabetes Mellitus, Experimental C00002063
D006943 Hyperglycemia C00002063
D007333 Insulin Resistance C00002063
D059606 Polydipsia C00002063