PCIDB

KNApSAcK Metabolite C00002327

Metabolite

KNApSAcK Entry

id C00002327
Name Colcin / Condylon / Colchisol / Colsaloid / Colchineos / Colchicine
CAS RN 64-86-8
Standard InChI InChI=1S/C22H25NO6/c1-12(24)23-16-8-6-13-10-19(27-3)21(28-4)22(29-5)20(13)14-7-9-18(26-2)17(25)11-15(14)16/h7,9-11,16H,6,8H2,1-5H3,(H,23,24)/t16-/m0/s1
Standard InChI (Main Layer) InChI=1S/C22H25NO6/c1-12(24)23-16-8-6-13-10-19(27-3)21(28-4)22(29-5)20(13)14-7-9-18(26-2)17(25)11-15(14)16/h7,9-11,16H,6,8H2,1-5H3,(H,23,24)

Cluster

Phytochemical cluster No. 4
KCF-S cluster No. 598

Link

ChEMBL

By standard InChI CHEMBL107
By standard InChI Main Layer CHEMBL87 CHEMBL107 CHEMBL330320

KEGG

By LinkDB C07592

CTD

By CAS RN D003078

Species

Summary

Plant class

class name count
Liliopsida 26

Family

family name count
Colchicaceae 25
Liliaceae 1

List (26)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Androcymbium burkei 59022 Colchicaceae Liliopsida Viridiplantae
Androcymbium capense 279449 Colchicaceae Liliopsida Viridiplantae
Androcymbium eucomoides 225769 Colchicaceae Liliopsida Viridiplantae
Androcymbium longipes Bak. 59022 Colchicaceae Liliopsida Viridiplantae
Androcymbium melanthioides var.stricta Baker. 59022 Colchicaceae Liliopsida Viridiplantae
Colchicum autumnale 45005 Colchicaceae Liliopsida Viridiplantae
Colchicum brachyphyllum 13444 Colchicaceae Liliopsida Viridiplantae
Colchicum cornigerum 13444 Colchicaceae Liliopsida Viridiplantae
Colchicum doerfleri 225784 Colchicaceae Liliopsida Viridiplantae
Colchicum kesselringii 481257 Colchicaceae Liliopsida Viridiplantae
Colchicum luteum Baker. 13444 Colchicaceae Liliopsida Viridiplantae
Colchicum megaphylla 13444 Colchicaceae Liliopsida Viridiplantae
Colchicum speciosum 13445 Colchicaceae Liliopsida Viridiplantae
Colchicum turicum 13444 Colchicaceae Liliopsida Viridiplantae
Gloriosa superba 41220 Colchicaceae Liliopsida Viridiplantae
Iphigenia stellata 177061 Colchicaceae Liliopsida Viridiplantae
Merendera bulbocodium 217491 Colchicaceae Liliopsida Viridiplantae
Merendera kurdica 217491 Colchicaceae Liliopsida Viridiplantae
Merendera manissadjianii 217491 Colchicaceae Liliopsida Viridiplantae
Merendera raddeana 217491 Colchicaceae Liliopsida Viridiplantae
Merendera robusta Bge. 217491 Colchicaceae Liliopsida Viridiplantae
Merendera sobolifera 217491 Colchicaceae Liliopsida Viridiplantae
Ornithoglossum viride Ait. 225804 Colchicaceae Liliopsida Viridiplantae
Sandersonia aurantica 61863 Liliaceae Liliopsida Viridiplantae
Wurmbea dioica F.Muell. 217519 Colchicaceae Liliopsida Viridiplantae
Wurmbea purpurea 217519 Colchicaceae Liliopsida Viridiplantae

Human Protein / Gene in interaction

150 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 CHEMBL107 CHEMBL330320 CHEMBL1614110 (1) CHEMBL1741321 (2)
CHEMBL1909136 (2) CHEMBL2071965 (1)
1 / 0
P04637 Cellular tumor antigen p53 Transcription Factor CHEMBL107 CHEMBL1613992 (1)
7 / 44
Q9Y6L6 Solute carrier organic anion transporter family member 1B1 Electrochemical transporter CHEMBL107 CHEMBL2169429 (1)
1 / 0
O94956 Solute carrier organic anion transporter family member 2B1 Unclassified protein CHEMBL107 CHEMBL2169431 (1)
0 / 0
Q99700 Ataxin-2 Unclassified protein CHEMBL330320 CHEMBL2114784 (1)
1 / 1
P21728 D(1A) dopamine receptor Dopamine receptor CHEMBL107 CHEMBL1909139 (2)
0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase CHEMBL107 CHEMBL1909131 (2)
0 / 3
Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH, Kv10-12.x (Ether-a-go-go) CHEMBL107 CHEMBL1909190 (2)
2 / 2
P08246 Neutrophil elastase S1A CHEMBL107 CHEMBL1909195 (2)
2 / 1
P33765 Adenosine receptor A3 Adenosine receptor CHEMBL107 CHEMBL1909215 (2)
0 / 0
Q16539 Mitogen-activated protein kinase 14 p38 CHEMBL107 CHEMBL1909201 (2)
0 / 0
P49146 Neuropeptide Y receptor type 2 Neuropeptide Y receptor CHEMBL107 CHEMBL1909176 (2)
0 / 0
P04062 Glucosylceramidase Enzyme CHEMBL107 CHEMBL1613818 (1)
6 / 4
P29466 Caspase-1 C14 CHEMBL107 CHEMBL1614158 (1) CHEMBL1909193 (2)
0 / 0
P17252 Protein kinase C alpha type Alpha CHEMBL107 CHEMBL1909198 (2)
0 / 0
P27361 Mitogen-activated protein kinase 3 Erk CHEMBL107 CHEMBL1909199 (2)
0 / 0
Q03181 Peroxisome proliferator-activated receptor delta NR1C2 CHEMBL107 CHEMBL1794524 (2) CHEMBL1794552 (2)
0 / 0
P14780 Matrix metalloproteinase-9 M10A CHEMBL107 CHEMBL1909197 (2)
2 / 2
O15245 Solute carrier family 22 member 1 Drug uniporter CHEMBL107 CHEMBL993349 (1)
0 / 0
Q92793 CREB-binding protein Enzyme CHEMBL107 CHEMBL1614040 (1) CHEMBL1614026 (1)
1 / 1
P02545 Prelamin-A/C Unclassified protein CHEMBL107 CHEMBL330320 CHEMBL1614310 (1) CHEMBL1614544 (3)
11 / 10
P23415 Glycine receptor subunit alpha-1 GLR alpha CHEMBL107 CHEMBL1629222 (1)
1 / 1
P16473 Thyrotropin receptor Glycohormone receptor CHEMBL107 CHEMBL330320 CHEMBL1614281 (2) CHEMBL1614361 (3)
3 / 2
P10828 Thyroid hormone receptor beta NR1A2 CHEMBL107 CHEMBL1794399 (2)
3 / 1
P19793 Retinoic acid receptor RXR-alpha NR2B1 CHEMBL107 CHEMBL1794371 (3) CHEMBL1794471 (1)
0 / 0
P00918 Carbonic anhydrase 2 Lyase CHEMBL107 CHEMBL1909123 (2)
1 / 2
P07550 Beta-2 adrenergic receptor Adrenergic receptor CHEMBL107 CHEMBL1909092 (2)
0 / 1
P21397 Amine oxidase [flavin-containing] A Oxidoreductase CHEMBL107 CHEMBL1909169 (2)
1 / 1
P25021 Histamine H2 receptor Histamine receptor CHEMBL107 CHEMBL1909157 (2)
0 / 0
P35367 Histamine H1 receptor Histamine receptor CHEMBL107 CHEMBL1909156 (2)
0 / 0
Q01959 Sodium-dependent dopamine transporter Dopamine CHEMBL107 CHEMBL1909143 (2)
1 / 0
P08912 Muscarinic acetylcholine receptor M5 Acetylcholine receptor CHEMBL107 CHEMBL1909174 (2)
0 / 0
P18825 Alpha-2C adrenergic receptor Adrenergic receptor CHEMBL107 CHEMBL1909090 (2)
0 / 0
P13945 Beta-3 adrenergic receptor Adrenergic receptor CHEMBL107 CHEMBL1909093 (2)
0 / 0
P08183 Multidrug resistance protein 1 drug CHEMBL107 CHEMBL755826 (1) CHEMBL755827 (1)
CHEMBL754160 (1) CHEMBL754161 (1)
CHEMBL1908285 (1) CHEMBL1908286 (1)
CHEMBL1908289 (1) CHEMBL1908291 (1)
CHEMBL1908292 (1) CHEMBL2077417 (1)
CHEMBL2076102 (1) CHEMBL2076103 (1)
CHEMBL2076285 (1) CHEMBL2076286 (1)
CHEMBL2077349 (1) CHEMBL2075838 (1)
CHEMBL2076207 (1) CHEMBL2076208 (1)
CHEMBL2076209 (1) CHEMBL2076217 (1)
CHEMBL2076219 (1)
1 / 0
P25024 C-X-C chemokine receptor type 1 CXC chemokine receptor CHEMBL107 CHEMBL1909127 (2)
0 / 0
P06241 Tyrosine-protein kinase Fyn Src CHEMBL107 CHEMBL1909204 (2)
0 / 0
Q08209 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform Ser_Thr CHEMBL107 CHEMBL1909202 (2)
0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 CHEMBL107 CHEMBL330320 CHEMBL1614027 (2) CHEMBL1741325 (2)
CHEMBL1909135 (2) CHEMBL2071963 (1)
0 / 1
Q9NR56 Muscleblind-like protein 1 Unclassified protein CHEMBL107 CHEMBL1614166 (2)
1 / 0
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily CHEMBL107 CHEMBL1909203 (2)
1 / 11
P11473 Vitamin D3 receptor NR1I1 CHEMBL107 CHEMBL1794376 (1)
2 / 3
P14416 D(2) dopamine receptor Dopamine receptor CHEMBL107 CHEMBL1909140 (2)
2 / 0
P23219 Prostaglandin G/H synthase 1 Oxidoreductase CHEMBL107 CHEMBL1909130 (2)
0 / 0
P37288 Vasopressin V1a receptor Vasopressin and oxytocin receptor CHEMBL107 CHEMBL1909120 (2)
0 / 0
P41145 Kappa-type opioid receptor Opioid receptor CHEMBL107 CHEMBL1909181 (2)
0 / 0
Q9Y271 Cysteinyl leukotriene receptor 1 Leukotriene receptor CHEMBL107 CHEMBL1909164 (2)
0 / 0
P29274 Adenosine receptor A2a Adenosine receptor CHEMBL107 CHEMBL1909214 (2)
0 / 0
P25929 Neuropeptide Y receptor type 1 Neuropeptide Y receptor CHEMBL107 CHEMBL1909175 (2)
0 / 0
P50052 Type-2 angiotensin II receptor Angiotensin receptor CHEMBL107 CHEMBL1909096 (2)
1 / 1
P17948 Vascular endothelial growth factor receptor 1 Vegfr CHEMBL107 CHEMBL1909118 (2)
0 / 0
P41968 Melanocortin receptor 3 Melanocortin receptor CHEMBL107 CHEMBL1909166 (2)
1 / 0
P11509 Cytochrome P450 2A6 Cytochrome P450 2A6 CHEMBL107 CHEMBL1909133 (2)
0 / 0
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor CHEMBL330320 CHEMBL1614456 (1) CHEMBL1613803 (1)
0 / 0
P39748 Flap endonuclease 1 Enzyme CHEMBL107 CHEMBL1794486 (1)
0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme CHEMBL87 CHEMBL1738606 (1)
0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein CHEMBL107 CHEMBL1794584 (1)
2 / 0
O75496 Geminin Unclassified protein CHEMBL87 CHEMBL107 CHEMBL1613941 (1) CHEMBL1738370 (1)
CHEMBL1738636 (1) CHEMBL1737957 (1)
CHEMBL2114843 (2) CHEMBL2114780 (3)
0 / 0
P51151 Ras-related protein Rab-9A Unclassified protein CHEMBL107 CHEMBL1613838 (2)
0 / 0
P23416 Glycine receptor subunit alpha-2 GLR alpha CHEMBL107 CHEMBL1629262 (1)
0 / 0
P04035 3-hydroxy-3-methylglutaryl-coenzyme A reductase Oxidoreductase CHEMBL107 CHEMBL1909158 (2)
0 / 0
P08913 Alpha-2A adrenergic receptor Adrenergic receptor CHEMBL107 CHEMBL1909088 (2)
0 / 0
P21917 D(4) dopamine receptor Dopamine receptor CHEMBL107 CHEMBL1909142 (2)
0 / 0
P30988 Calcitonin receptor Calcitonin receptor CHEMBL107 CHEMBL1909101 (2)
0 / 0
P35462 D(3) dopamine receptor Dopamine receptor CHEMBL107 CHEMBL1909141 (2)
1 / 0
P41143 Delta-type opioid receptor Opioid receptor CHEMBL107 CHEMBL1909180 (2)
0 / 0
Q92731 Estrogen receptor beta NR3A2 CHEMBL107 CHEMBL1909146 (2)
0 / 1
P41595 5-hydroxytryptamine receptor 2B Serotonin receptor CHEMBL107 CHEMBL1909104 (2)
0 / 0
P25101 Endothelin-1 receptor Endothelin receptor CHEMBL107 CHEMBL1909144 (2)
0 / 0
P30411 B2 bradykinin receptor Bradykinin receptor CHEMBL107 CHEMBL1909100 (2)
0 / 0
P10145 Interleukin-8 Secreted protein CHEMBL107 CHEMBL2114835 (2)
0 / 0
P32245 Melanocortin receptor 4 Melanocortin receptor CHEMBL107 CHEMBL1909167 (2)
1 / 0
P32238 Cholecystokinin receptor type A Cholecystokinin receptor CHEMBL107 CHEMBL1909129 (2)
0 / 0
P08311 Cathepsin G S1A CHEMBL107 CHEMBL1909194 (2)
0 / 0
Q99720 Sigma non-opioid intracellular receptor 1 Membrane receptor CHEMBL107 CHEMBL1909110 (2)
1 / 0
P03956 Interstitial collagenase M10A CHEMBL107 CHEMBL1909196 (2)
0 / 1
P32241 Vasoactive intestinal polypeptide receptor 1 Vasoactive intestinal peptide receptor CHEMBL107 CHEMBL1909119 (2)
0 / 0
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein CHEMBL87 CHEMBL2114817 (1)
7 / 3
Q03164 Histone-lysine N-methyltransferase 2A Enzyme CHEMBL87 CHEMBL1614410 (1)
1 / 3
P83916 Chromobox protein homolog 1 Unclassified protein CHEMBL107 CHEMBL1738610 (1)
0 / 0
Q9NPD5 Solute carrier organic anion transporter family member 1B3 Electrochemical transporter CHEMBL107 CHEMBL2169430 (1)
1 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme CHEMBL107 CHEMBL1794467 (1)
0 / 0
P51843 Nuclear receptor subfamily 0 group B member 1 Nuclear hormone receptor subfamily 0 group B member 1 CHEMBL107 CHEMBL2354292 (1)
2 / 2
P04150 Glucocorticoid receptor NR3C1 CHEMBL107 CHEMBL1794382 (1) CHEMBL1794456 (1)
CHEMBL1909150 (2)
0 / 1
P08172 Muscarinic acetylcholine receptor M2 Acetylcholine receptor CHEMBL107 CHEMBL1909171 (2)
2 / 0
P11229 Muscarinic acetylcholine receptor M1 Acetylcholine receptor CHEMBL107 CHEMBL1909170 (2)
0 / 0
P21554 Cannabinoid receptor 1 Cannabinoid receptor CHEMBL107 CHEMBL1909122 (2)
0 / 0
P31645 Sodium-dependent serotonin transporter Serotonin CHEMBL107 CHEMBL1909109 (2)
2 / 0
P37231 Peroxisome proliferator-activated receptor gamma NR1C3 CHEMBL107 CHEMBL1794510 (3)
5 / 3
P04626 Receptor tyrosine-protein kinase erbB-2 TK tyrosine-protein kinase EGFR subfamily CHEMBL107 CHEMBL1909205 (2)
5 / 10
P20309 Muscarinic acetylcholine receptor M3 Acetylcholine receptor CHEMBL107 CHEMBL1909172 (2)
1 / 0
P21452 Substance-K receptor Neurokinin receptor CHEMBL107 CHEMBL1909114 (2)
0 / 0
P51679 C-C chemokine receptor type 4 CC chemokine receptor CHEMBL107 CHEMBL1909125 (2)
0 / 0
P51681 C-C chemokine receptor type 5 CC chemokine receptor CHEMBL107 CHEMBL1909126 (2)
3 / 0
P50406 5-hydroxytryptamine receptor 6 Serotonin receptor CHEMBL107 CHEMBL1909108 (2)
0 / 0
Q96RI1 Bile acid receptor NR1H4 CHEMBL107 CHEMBL1794415 (2) CHEMBL1794437 (1)
0 / 0
P41597 C-C chemokine receptor type 2 CC chemokine receptor CHEMBL107 CHEMBL1909124 (2)
1 / 0
P28482 Mitogen-activated protein kinase 1 Erk CHEMBL107 CHEMBL1909200 (2)
0 / 0
P08575 Receptor-type tyrosine-protein phosphatase C Enzyme CHEMBL107 CHEMBL1909207 (2)
2 / 1
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 CHEMBL107 CHEMBL330320 CHEMBL1741322 (2) CHEMBL1909132 (2)
CHEMBL2071962 (1)
0 / 0
Q92887 Canalicular multispecific organic anion transporter 1 Unclassified protein CHEMBL107 CHEMBL1006005 (1)
1 / 1
O75030 Microphthalmia-associated transcription factor Unclassified protein CHEMBL87 CHEMBL1738671 (1) CHEMBL1737866 (1)
CHEMBL1738318 (1)
4 / 5
P51449 Nuclear receptor ROR-gamma Nuclear hormone receptor subfamily 1 group F member 3 CHEMBL107 CHEMBL2114842 (2)
0 / 0
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein CHEMBL87 CHEMBL107 CHEMBL1738588 (2) CHEMBL1737868 (1)
0 / 0
O76074 cGMP-specific 3',5'-cyclic phosphodiesterase PDE_5A CHEMBL107 CHEMBL1909186 (2)
0 / 0
P03372 Estrogen receptor NR3A1 CHEMBL107 CHEMBL1794542 (1) CHEMBL1909145 (2)
1 / 1
P08588 Beta-1 adrenergic receptor Adrenergic receptor CHEMBL107 CHEMBL1909091 (2)
1 / 0
P22303 Acetylcholinesterase Hydrolase CHEMBL107 CHEMBL1909212 (2)
1 / 0
P28223 5-hydroxytryptamine receptor 2A Serotonin receptor CHEMBL107 CHEMBL1909211 (2)
0 / 0
P28335 5-hydroxytryptamine receptor 2C Serotonin receptor CHEMBL107 CHEMBL1909105 (2)
0 / 0
P35372 Mu-type opioid receptor Opioid receptor CHEMBL107 CHEMBL1909182 (2)
0 / 0
P08173 Muscarinic acetylcholine receptor M4 Acetylcholine receptor CHEMBL107 CHEMBL1909173 (2)
0 / 0
P25103 Substance-P receptor Neurokinin receptor CHEMBL107 CHEMBL1909113 (2)
0 / 0
P25105 Platelet-activating factor receptor PAF receptor CHEMBL107 CHEMBL1909187 (2)
0 / 0
P33032 Melanocortin receptor 5 Melanocortin receptor CHEMBL107 CHEMBL1909168 (2)
0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 CHEMBL107 CHEMBL330320 CHEMBL1613777 (1) CHEMBL1741323 (2)
CHEMBL1909134 (2) CHEMBL2071964 (1)
1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 CHEMBL107 CHEMBL330320 CHEMBL664809 (1) CHEMBL836230 (1)
CHEMBL1614108 (1) CHEMBL1613886 (1)
CHEMBL1741324 (2) CHEMBL1909138 (2)
CHEMBL2071966 (1) CHEMBL2071967 (1)
0 / 1
P05181 Cytochrome P450 2E1 Cytochrome P450 2E1 CHEMBL107 CHEMBL1909137 (2)
0 / 0
Q6W5P4 Neuropeptide S receptor Neuropeptide receptor CHEMBL107 CHEMBL1614052 (1)
1 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein CHEMBL87 CHEMBL107 CHEMBL1737980 (1) CHEMBL1738184 (2)
CHEMBL2114890 (3)
0 / 0
P10275 Androgen receptor NR3C4 CHEMBL107 CHEMBL1794560 (2)
3 / 4
P23975 Sodium-dependent noradrenaline transporter Norepinephrine CHEMBL107 CHEMBL1909094 (2)
1 / 1
P25100 Alpha-1D adrenergic receptor Adrenergic receptor CHEMBL107 CHEMBL1909087 (2)
0 / 0
P30542 Adenosine receptor A1 Adenosine receptor CHEMBL107 CHEMBL1909213 (2)
0 / 0
P18089 Alpha-2B adrenergic receptor Adrenergic receptor CHEMBL107 CHEMBL1909089 (2)
0 / 0
P24557 Thromboxane-A synthase Cytochrome P450 5A1 CHEMBL107 CHEMBL1909116 (2)
1 / 1
P06239 Tyrosine-protein kinase Lck Src CHEMBL107 CHEMBL1909206 (2)
0 / 1
P25025 C-X-C chemokine receptor type 2 CXC chemokine receptor CHEMBL107 CHEMBL1909128 (2)
0 / 0
P40225 Thrombopoietin Unclassified protein CHEMBL107 CHEMBL1614086 (1) CHEMBL1614034 (1)
1 / 1
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme CHEMBL107 CHEMBL1738442 (1)
0 / 0
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme CHEMBL87 CHEMBL107 CHEMBL2354311 (2)
1 / 0
O75751 Solute carrier family 22 member 3 Unclassified protein CHEMBL107 CHEMBL2075864 (1)
0 / 0
P11388 DNA topoisomerase 2-alpha Isomerase CHEMBL107 CHEMBL817421 (1) CHEMBL847691 (1)
0 / 0
Q02880 DNA topoisomerase 2-beta Isomerase CHEMBL107 CHEMBL817421 (1) CHEMBL847691 (1)
0 / 0
Q13748 Tubulin alpha-3C/D chain Structural CHEMBL107 CHEMBL330320 CHEMBL698214 (1) CHEMBL818984 (1)
CHEMBL820637 (2) CHEMBL820638 (1)
CHEMBL819249 (1) CHEMBL819251 (1)
CHEMBL816885 (1) CHEMBL817774 (1)
CHEMBL817775 (1) CHEMBL845253 (1)
CHEMBL861004 (1) CHEMBL870821 (1)
CHEMBL910862 (1) CHEMBL907127 (1)
CHEMBL912968 (1)
0 / 0
P68366 Tubulin alpha-4A chain Structural CHEMBL107 CHEMBL330320 CHEMBL698214 (1) CHEMBL818984 (1)
CHEMBL820637 (2) CHEMBL820638 (1)
CHEMBL819249 (1) CHEMBL819251 (1)
CHEMBL816885 (1) CHEMBL817774 (1)
CHEMBL817775 (1) CHEMBL845253 (1)
CHEMBL861004 (1) CHEMBL870821 (1)
CHEMBL910862 (1) CHEMBL907127 (1)
CHEMBL912968 (1)
0 / 0
Q9H4B7 Tubulin beta-1 chain Structural CHEMBL107 CHEMBL330320 CHEMBL698214 (1) CHEMBL818984 (1)
CHEMBL820637 (2) CHEMBL820638 (1)
CHEMBL819249 (1) CHEMBL819251 (1)
CHEMBL816885 (1) CHEMBL817774 (1)
CHEMBL817775 (1) CHEMBL845253 (1)
CHEMBL861004 (1) CHEMBL870821 (1)
CHEMBL910862 (1) CHEMBL907127 (1)
CHEMBL912968 (1)
1 / 0
P04350 Tubulin beta-4A chain Structural CHEMBL107 CHEMBL330320 CHEMBL698214 (1) CHEMBL818984 (1)
CHEMBL820637 (2) CHEMBL820638 (1)
CHEMBL819249 (1) CHEMBL819251 (1)
CHEMBL816885 (1) CHEMBL817774 (1)
CHEMBL817775 (1) CHEMBL845253 (1)
CHEMBL861004 (1) CHEMBL870821 (1)
CHEMBL910862 (1) CHEMBL907127 (1)
CHEMBL912968 (1)
2 / 0
Q3ZCM7 Tubulin beta-8 chain Structural CHEMBL107 CHEMBL330320 CHEMBL698214 (1) CHEMBL818984 (1)
CHEMBL820637 (2) CHEMBL820638 (1)
CHEMBL819249 (1) CHEMBL819251 (1)
CHEMBL816885 (1) CHEMBL817774 (1)
CHEMBL817775 (1) CHEMBL845253 (1)
CHEMBL861004 (1) CHEMBL870821 (1)
CHEMBL910862 (1) CHEMBL907127 (1)
CHEMBL912968 (1)
0 / 0
P07437 Tubulin beta chain Structural CHEMBL107 CHEMBL330320 CHEMBL698214 (1) CHEMBL818984 (1)
CHEMBL820637 (2) CHEMBL820638 (1)
CHEMBL819249 (1) CHEMBL819251 (1)
CHEMBL816885 (1) CHEMBL817774 (1)
CHEMBL817775 (1) CHEMBL845253 (1)
CHEMBL861004 (1) CHEMBL870821 (1)
CHEMBL910862 (1) CHEMBL907127 (1)
CHEMBL912968 (1)
0 / 0
Q71U36 Tubulin alpha-1A chain Structural CHEMBL107 CHEMBL330320 CHEMBL698214 (1) CHEMBL818984 (1)
CHEMBL820637 (2) CHEMBL820638 (1)
CHEMBL819249 (1) CHEMBL819251 (1)
CHEMBL816885 (1) CHEMBL817774 (1)
CHEMBL817775 (1) CHEMBL845253 (1)
CHEMBL861004 (1) CHEMBL870821 (1)
CHEMBL910862 (1) CHEMBL907127 (1)
CHEMBL912968 (1)
1 / 1
P68371 Tubulin beta-4B chain Structural CHEMBL107 CHEMBL330320 CHEMBL698214 (1) CHEMBL818984 (1)
CHEMBL820637 (2) CHEMBL820638 (1)
CHEMBL819249 (1) CHEMBL819251 (1)
CHEMBL816885 (1) CHEMBL817774 (1)
CHEMBL817775 (1) CHEMBL845253 (1)
CHEMBL861004 (1) CHEMBL870821 (1)
CHEMBL910862 (1) CHEMBL907127 (1)
CHEMBL912968 (1)
0 / 0
Q13509 Tubulin beta-3 chain Structural CHEMBL107 CHEMBL330320 CHEMBL698214 (1) CHEMBL818984 (1)
CHEMBL820637 (2) CHEMBL820638 (1)
CHEMBL819249 (1) CHEMBL819251 (1)
CHEMBL816885 (1) CHEMBL817774 (1)
CHEMBL817775 (1) CHEMBL845253 (1)
CHEMBL861004 (1) CHEMBL870821 (1)
CHEMBL910862 (1) CHEMBL907127 (1)
CHEMBL912968 (1)
2 / 1
Q06710 Paired box protein Pax-8 Unclassified protein CHEMBL87 CHEMBL107 CHEMBL2354301 (2)
1 / 2
P68363 Tubulin alpha-1B chain Unclassified protein CHEMBL107 CHEMBL330320 CHEMBL698214 (1) CHEMBL818984 (1)
CHEMBL820637 (2) CHEMBL820638 (1)
CHEMBL819249 (1) CHEMBL819251 (1)
CHEMBL816885 (1) CHEMBL817774 (1)
CHEMBL817775 (1) CHEMBL845253 (1)
CHEMBL861004 (1) CHEMBL870821 (1)
CHEMBL910862 (1) CHEMBL907127 (1)
CHEMBL912968 (1)
0 / 0
Q13885 Tubulin beta-2A chain Structural CHEMBL107 CHEMBL330320 CHEMBL698214 (1) CHEMBL818984 (1)
CHEMBL820637 (2) CHEMBL820638 (1)
CHEMBL819249 (1) CHEMBL819251 (1)
CHEMBL816885 (1) CHEMBL817774 (1)
CHEMBL817775 (1) CHEMBL845253 (1)
CHEMBL861004 (1) CHEMBL870821 (1)
CHEMBL910862 (1) CHEMBL907127 (1)
CHEMBL912968 (1)
0 / 0
Q6PEY2 Tubulin alpha-3E chain Unclassified protein CHEMBL107 CHEMBL330320 CHEMBL698214 (1) CHEMBL818984 (1)
CHEMBL820637 (2) CHEMBL820638 (1)
CHEMBL819249 (1) CHEMBL819251 (1)
CHEMBL816885 (1) CHEMBL817774 (1)
CHEMBL817775 (1) CHEMBL845253 (1)
CHEMBL861004 (1) CHEMBL870821 (1)
CHEMBL910862 (1) CHEMBL907127 (1)
CHEMBL912968 (1)
0 / 0
Q9BQE3 Tubulin alpha-1C chain Unclassified protein CHEMBL107 CHEMBL330320 CHEMBL698214 (1) CHEMBL818984 (1)
CHEMBL820637 (2) CHEMBL820638 (1)
CHEMBL819249 (1) CHEMBL819251 (1)
CHEMBL816885 (1) CHEMBL817774 (1)
CHEMBL817775 (1) CHEMBL845253 (1)
CHEMBL861004 (1) CHEMBL870821 (1)
CHEMBL910862 (1) CHEMBL907127 (1)
CHEMBL912968 (1)
0 / 0
Q9BUF5 Tubulin beta-6 chain Structural CHEMBL107 CHEMBL330320 CHEMBL698214 (1) CHEMBL818984 (1)
CHEMBL820637 (2) CHEMBL820638 (1)
CHEMBL819249 (1) CHEMBL819251 (1)
CHEMBL816885 (1) CHEMBL817774 (1)
CHEMBL817775 (1) CHEMBL845253 (1)
CHEMBL861004 (1) CHEMBL870821 (1)
CHEMBL910862 (1) CHEMBL907127 (1)
CHEMBL912968 (1)
0 / 0
Q9BVA1 Tubulin beta-2B chain Structural CHEMBL107 CHEMBL330320 CHEMBL698214 (1) CHEMBL818984 (1)
CHEMBL820637 (2) CHEMBL820638 (1)
CHEMBL819249 (1) CHEMBL819251 (1)
CHEMBL816885 (1) CHEMBL817774 (1)
CHEMBL817775 (1) CHEMBL845253 (1)
CHEMBL861004 (1) CHEMBL870821 (1)
CHEMBL910862 (1) CHEMBL907127 (1)
CHEMBL912968 (1)
1 / 0

CTD interaction (63)

compound gene gene name gene description interaction interaction type form reference
pmid
D003078 5243 ABCB1
ABC20
CD243
CLCS
GP170
MDR1
P-GP
PGY1
ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) ABCB1 protein affects the transport of Colchicine affects transport
protein 16007523
D003078 5243 ABCB1
ABC20
CD243
CLCS
GP170
MDR1
P-GP
PGY1
ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) ABCB1 protein results in decreased susceptibility to Colchicine decreases response to substance
protein 7905786
15112361
15725475
D003078 5243 ABCB1
ABC20
CD243
CLCS
GP170
MDR1
P-GP
PGY1
ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) ABCB1 protein results in increased export of Colchicine increases export
protein 15112361
D003078 5243 ABCB1
ABC20
CD243
CLCS
GP170
MDR1
P-GP
PGY1
ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) Colchicine inhibits the reaction [Verapamil analog results in increased activity of ABCB1 protein mutant form] decreases reaction
/ increases activity
protein 12711602
D003078 5243 ABCB1
ABC20
CD243
CLCS
GP170
MDR1
P-GP
PGY1
ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) Colchicine results in increased expression of ABCB1 mRNA increases expression
mRNA 15342794
D003078 5243 ABCB1
ABC20
CD243
CLCS
GP170
MDR1
P-GP
PGY1
ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) [MGMT protein co-treated with ABCB1 protein] results in decreased susceptibility to Colchicine affects cotreatment
/ decreases response to substance
protein 11792417
D003078 4363 ABCC1
ABC29
ABCC
GS-X
MRP
MRP1
ATP-binding cassette, sub-family C (CFTR/MRP), member 1 ABCC1 protein results in decreased susceptibility to Colchicine decreases response to substance
protein 12067707
D003078 196 AHR
bHLHe76
aryl hydrocarbon receptor Colchicine results in decreased activity of AHR protein decreases activity
protein 16611024
D003078 213 ALB
PRO0883
PRO0903
PRO1341
albumin Colchicine affects the expression of ALB protein affects expression
protein 8574231
D003078 9212 AURKB
AIK2
AIM-1
AIM1
ARK2
AurB
IPL1
PPP1R48
STK12
STK5
aurkb-sv1
aurkb-sv2
aurora kinase B (EC:2.7.11.1) Colchicine results in increased expression of AURKB mRNA increases expression
mRNA 21472861
D003078 581 BAX
BCL2L4
BCL2-associated X protein Colchicine results in increased expression of BAX protein increases expression
protein 22342440
D003078 596 BCL2
Bcl-2
PPP1R50
B-cell CLL/lymphoma 2 Colchicine results in decreased expression of BCL2 protein decreases expression
protein 22342440
D003078 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) Colchicine results in increased activity of CASP3 protein increases activity
protein 22342440
D003078 842 CASP9
APAF-3
APAF3
ICE-LAP6
MCH6
PPP1R56
caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) Colchicine results in increased activity of CASP9 protein increases activity
protein 22342440
D003078 891 CCNB1
CCNB
cyclin B1 Colchicine results in increased expression of CCNB1 mRNA increases expression
mRNA 21472861
D003078 966 CD59
16.3A5
1F5
EJ16
EJ30
EL32
G344
HRF-20
HRF20
MAC-IP
MACIF
MEM43
MIC11
MIN1
MIN2
MIN3
MIRL
MSK21
p18-20
CD59 molecule, complement regulatory protein Colchicine results in increased mutagenesis of CD59 protein increases mutagenesis
protein 17045307
D003078 999 CDH1
Arc-1
CD324
CDHE
ECAD
LCAM
UVO
cadherin 1, type 1, E-cadherin (epithelial) Colchicine affects the activity of CDH1 protein affects activity
protein 10413674
D003078 10659 CELF2
BRUNOL3
CUGBP2
ETR-3
ETR3
NAPOR
CUGBP, Elav-like family member 2 2-cyclopentyl-5-(5-isoquinolylsulfonyl)-6-nitro-1H-benzo(D)imidazole inhibits the reaction [Colchicine results in increased expression of CELF2 mRNA] decreases reaction
/ increases expression
mRNA 11478917
D003078 10659 CELF2
BRUNOL3
CUGBP2
ETR-3
ETR3
NAPOR
CUGBP, Elav-like family member 2 Colchicine results in increased expression of CELF2 mRNA increases expression
mRNA 11478917
D003078 1437 CSF2
GMCSF
colony stimulating factor 2 (granulocyte-macrophage) Colchicine inhibits the reaction [kaempferol results in increased secretion of CSF2 protein] decreases reaction
/ increases secretion
protein 18346843
D003078 1437 CSF2
GMCSF
colony stimulating factor 2 (granulocyte-macrophage) Colchicine inhibits the reaction [Quercetin results in increased secretion of CSF2 protein] decreases reaction
/ increases secretion
protein 18346843
D003078 1543 CYP1A1
AHH
AHRR
CP11
CYP1
P1-450
P450-C
P450DX
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) Colchicine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein] decreases reaction
/ increases activity
protein 16611024
D003078 1543 CYP1A1
AHH
AHRR
CP11
CYP1
P1-450
P450-C
P450DX
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) Colchicine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA] decreases reaction
/ increases expression
mRNA 16611024
D003078 1543 CYP1A1
AHH
AHRR
CP11
CYP1
P1-450
P450-C
P450DX
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) Colchicine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein] decreases reaction
/ increases expression
protein 16611024
D003078 1576 CYP3A4
CP33
CP34
CYP3A
CYP3A3
CYPIIIA3
CYPIIIA4
HLP
NF-25
P450C3
P450PCN1
cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) CYP3A4 protein affects the metabolism of Colchicine affects metabolic processing
protein 15914514
16007523
D003078 2147 F2
PT
RPRGL2
THPH1
coagulation factor II (thrombin) (EC:3.4.21.5) Colchicine affects the activity of F2 protein affects activity
protein 8574231
D003078 3551 IKBKB
IKK-beta
IKK2
IKKB
NFKBIKB
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta (EC:2.7.11.10) Colchicine results in decreased localization of [IKBKB protein binds to NFKBIA protein] affects binding
/ decreases localization
protein 17029595
D003078 3551 IKBKB
IKK-beta
IKK2
IKKB
NFKBIKB
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta (EC:2.7.11.10) Colchicine results in increased phosphorylation of IKBKB protein increases phosphorylation
protein 17029595
D003078 3552 IL1A
IL-1A
IL1
IL1-ALPHA
IL1F1
interleukin 1, alpha Colchicine inhibits the reaction [IL1A protein results in increased expression of VCAM1 protein] decreases reaction
/ increases expression
protein 11154858
D003078 3558 IL2
IL-2
TCGF
lymphokine
interleukin 2 Colchicine results in decreased expression of IL2 protein decreases expression
protein 1553933
D003078 3725 JUN
AP-1
AP1
c-Jun
jun proto-oncogene Colchicine results in increased phosphorylation of JUN protein increases phosphorylation
protein 12221076
D003078 3725 JUN
AP-1
AP1
c-Jun
jun proto-oncogene TP53 protein affects the reaction [Colchicine results in increased phosphorylation of JUN protein] affects reaction
/ increases phosphorylation
protein 12221076
D003078 3875 KRT18
CYK18
K18
keratin 18 Colchicine results in decreased expression of KRT18 protein decreases expression
protein 11259854
D003078 5599 MAPK8
JNK
JNK-46
JNK1
JNK1A2
JNK21B1/2
PRKM8
SAPK1
SAPK1c
mitogen-activated protein kinase 8 (EC:2.7.11.24) Colchicine results in increased phosphorylation of MAPK8 protein increases phosphorylation
protein 12221076
D003078 5599 MAPK8
JNK
JNK-46
JNK1
JNK1A2
JNK21B1/2
PRKM8
SAPK1
SAPK1c
mitogen-activated protein kinase 8 (EC:2.7.11.24) TP53 protein affects the reaction [Colchicine results in increased phosphorylation of MAPK8 protein] affects reaction
/ increases phosphorylation
protein 12221076
D003078 5601 MAPK9
JNK-55
JNK2
JNK2A
JNK2ALPHA
JNK2B
JNK2BETA
PRKM9
SAPK
SAPK1a
p54a
p54aSAPK
mitogen-activated protein kinase 9 (EC:2.7.11.24) Colchicine results in increased phosphorylation of MAPK9 protein increases phosphorylation
protein 12221076
D003078 5601 MAPK9
JNK-55
JNK2
JNK2A
JNK2ALPHA
JNK2B
JNK2BETA
PRKM9
SAPK
SAPK1a
p54a
p54aSAPK
mitogen-activated protein kinase 9 (EC:2.7.11.24) TP53 protein affects the reaction [Colchicine results in increased phosphorylation of MAPK9 protein] affects reaction
/ increases phosphorylation
protein 12221076
D003078 4137 MAPT
DDPAC
FTDP-17
MAPTL
MSTD
MTBT1
MTBT2
PPND
TAU
microtubule-associated protein tau Colchicine results in decreased expression of MAPT protein decreases expression
protein 16930453
D003078 4255 MGMT
O-6-methylguanine-DNA methyltransferase (EC:2.1.1.63) [MGMT protein co-treated with ABCB1 protein] results in decreased susceptibility to Colchicine affects cotreatment
/ decreases response to substance
protein 11792417
D003078 4661 MYT1
C20orf36
MTF1
MYTI
PLPB1
ZC2HC4A
myelin transcription factor 1 Colchicine results in increased phosphorylation of MYT1 protein increases phosphorylation
protein 16611024
D003078 4776 NFATC4
NF-ATc4
NFAT3
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 Colchicine results in decreased localization of NFATC4 protein decreases localization
protein 17044076
D003078 4792 NFKBIA
IKBA
MAD-3
NFKBI
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha Colchicine results in decreased localization of [IKBKB protein binds to NFKBIA protein] affects binding
/ decreases localization
protein 17029595
D003078 4792 NFKBIA
IKBA
MAD-3
NFKBI
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha Colchicine results in increased phosphorylation of NFKBIA protein increases phosphorylation
protein 17029595
D003078 2908 NR3C1
GCCR
GCR
GR
GRL
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) Colchicine results in decreased localization of and results in decreased activity of NR3C1 protein decreases activity
/ decreases localization
protein 15744361
D003078 2908 NR3C1
GCCR
GCR
GR
GRL
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) Colchicine results in increased activity of NR3C1 protein increases activity
protein 20448266
D003078 2908 NR3C1
GCCR
GCR
GR
GRL
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) Colchicine results in increased degradation of NR3C1 protein increases degradation
protein 20448266
D003078 2185 PTK2B
CADTK
CAKB
FADK2
FAK2
PKB
PTK
PYK2
RAFTK
protein tyrosine kinase 2 beta (EC:2.7.10.2) 2-cyclopentyl-5-(5-isoquinolylsulfonyl)-6-nitro-1H-benzo(D)imidazole inhibits the reaction [Colchicine results in increased phosphorylation of PTK2B protein] decreases reaction
/ increases phosphorylation
protein 11478917
D003078 2185 PTK2B
CADTK
CAKB
FADK2
FAK2
PKB
PTK
PYK2
RAFTK
protein tyrosine kinase 2 beta (EC:2.7.10.2) Colchicine results in increased phosphorylation of PTK2B protein increases phosphorylation
protein 11478917
D003078 10928 RALBP1
RIP1
RLIP1
RLIP76
ralA binding protein 1 Colchicine inhibits the reaction [RALBP1 protein affects the transport of Leukotriene C4] affects transport
/ decreases reaction
protein 15386349
D003078 10928 RALBP1
RIP1
RLIP1
RLIP76
ralA binding protein 1 RALBP1 protein affects the transport of Colchicine affects transport
protein 15386349
D003078 6898 TAT
tyrosine aminotransferase (EC:2.6.1.5) anthra(1,9-cd)pyrazol-6(2H)-one inhibits the reaction [Colchicine results in decreased expression of TAT mRNA] decreases expression
/ decreases reaction
mRNA 15744361
D003078 6898 TAT
tyrosine aminotransferase (EC:2.6.1.5) Colchicine results in decreased expression of TAT mRNA decreases expression
mRNA 15744361
D003078 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Colchicine inhibits the reaction [TNF protein results in increased expression of VCAM1 protein] decreases reaction
/ increases expression
protein 11154858
D003078 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Colchicine results in decreased expression of TNF protein decreases expression
protein 1553933
D003078 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Paclitaxel inhibits the reaction [Colchicine inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]] decreases reaction
/ increases expression
protein 11154858
D003078 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Paclitaxel inhibits the reaction [Colchicine inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]] decreases reaction
/ increases expression
protein 11154858
D003078 7157 TP53
BCC7
LFS1
P53
TRP53
tumor protein p53 TP53 protein affects the reaction [Colchicine results in increased phosphorylation of JUN protein] affects reaction
/ increases phosphorylation
protein 12221076
D003078 7157 TP53
BCC7
LFS1
P53
TRP53
tumor protein p53 TP53 protein affects the reaction [Colchicine results in increased phosphorylation of MAPK8 protein] affects reaction
/ increases phosphorylation
protein 12221076
D003078 7157 TP53
BCC7
LFS1
P53
TRP53
tumor protein p53 TP53 protein affects the reaction [Colchicine results in increased phosphorylation of MAPK9 protein] affects reaction
/ increases phosphorylation
protein 12221076
D003078 7412 VCAM1
CD106
INCAM-100
vascular cell adhesion molecule 1 Colchicine inhibits the reaction [IL1A protein results in increased expression of VCAM1 protein] decreases reaction
/ increases expression
protein 11154858
D003078 7412 VCAM1
CD106
INCAM-100
vascular cell adhesion molecule 1 Colchicine inhibits the reaction [TNF protein results in increased expression of VCAM1 protein] decreases reaction
/ increases expression
protein 11154858
D003078 7412 VCAM1
CD106
INCAM-100
vascular cell adhesion molecule 1 Paclitaxel inhibits the reaction [Colchicine inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]] decreases reaction
/ increases expression
mRNA 11154858
D003078 7412 VCAM1
CD106
INCAM-100
vascular cell adhesion molecule 1 Paclitaxel inhibits the reaction [Colchicine inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]] decreases reaction
/ increases expression
protein 11154858

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (106)

OMIM preferred title UniProt
#300018 46,xy sex reversal 2; srxy2 P51843
#100100 Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism P20309
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#300200 Adrenal hypoplasia, congenital; ahc P51843
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#103470 Albinism, ocular, with sensorineural deafness O75030
#103780 Alcohol dependence P08172
P14416
P31645
#614373 Amyotrophic lateral sclerosis 16, juvenile; als16 Q99720
#300068 Androgen insensitivity syndrome; ais P10275
#312300 Androgen insensitivity, partial; pais P10275
#608584 Asthma-related traits, susceptibility to, 2 Q6W5P4
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#602025 Body mass index quantitative trait locus 9; bmiq9 P41968
%606641 Body mass index; bmi P37231
#300615 Brunner syndrome P21397
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#609338 Carotid intimal medial thickness 1 P37231
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#114500 Colorectal cancer; crc P84022
#614039 Cortical dysplasia, complex, with other brain malformations 1; cdcbm1 Q13509
#162800 Cyclic neutropenia P08246
#612522 Diabetes mellitus, insulin-dependent, 22; iddm22 P51681
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#237500 Dubin-johnson syndrome; djs Q92887
#128101 Dystonia 4, torsion, autosomal dominant; dyt4 P04350
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#133239 Esophageal cancer P04637
#615363 Estrogen resistance; estrr P03372
#600638 Fibrosis of extraocular muscles, congenital, 3a, with or without extraocular involvement; cfeom3a Q13509
#613659 Gastric cancer P04626
#137215 Gastric cancer, hereditary diffuse; hdgc P04626
#608013 Gaucher disease, perinatal lethal P04062
#230800 Gaucher disease, type i P04062
#230900 Gaucher disease, type ii P04062
#231000 Gaucher disease, type iii P04062
#231005 Gaucher disease, type iiic P04062
#231095 Ghosal hematodiaphyseal dysplasia; ghdd P24557
#137800 Glioma susceptibility 1; glm1 O75874
P04626
P37231
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#609423 Human immunodeficiency virus type 1, susceptibility to P41597
P51681
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#237450 Hyperbilirubinemia, rotor type; hblrr Q9NPD5
Q9Y6L6
#149400 Hyperekplexia, hereditary 1; hkpx1 P23415
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#218700 Hypothyroidism, congenital, nongoitrous, 2; chng2 Q06710
#612244 Inflammatory bowel disease 13; ibd13 P08183
#603932 Intervertebral disc disease; idd P14780
#612438 Leukodystrophy, hypomyelinating, 6; hld6 P04350
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#604367 Lipodystrophy, familial partial, type 3; fpld3 P37231
#611603 Lissencephaly 3; lis3 Q71U36
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#613688 Long qt syndrome 2; lqt2 Q12809
#211980 Lung cancer P00533
P04626
P04637
#613112 Macrothrombocytopenia, autosomal dominant, tubb1-related Q9H4B7
#608516 Major depressive disorder; mdd P08172
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#174800 Mccune-albright syndrome; mas P63092
#614456 Melanoma, cutaneous malignant, susceptibility to, 8; cmm8 O75030
%300852 Mental retardation, x-linked 88; mrx88 P50052
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#126200 Multiple sclerosis, susceptibility to; ms P08575
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#159900 Myoclonic dystonia P14416
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#202700 Neutropenia, severe congenital, 1, autosomal dominant; scn1 P08246
#601665 Obesity P32245
P37231
#164230 Obsessive-compulsive disorder; ocd P31645
#604715 Orthostatic intolerance P23975
#166350 Osseous heteroplasia, progressive; poh P63092
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#167000 Ovarian cancer P04626
#260500 Papilloma of choroid plexus; cpp P04637
#168600 Parkinson disease, late-onset; pd P04062
#613135 Parkinsonism-dystonia, infantile; pkdys Q01959
#102200 Pituitary adenoma, growth hormone-secreting P63092
#610031 Polymicrogyria, symmetric or asymmetric; pmgysa Q9BVA1
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#607276 Resting heart rate, variation in P08588
#275210 Restrictive dermopathy, lethal P02545
#180849 Rubinstein-taybi syndrome 1; rsts1 Q92793
#608971 Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive P08575
#609620 Short qt syndrome 1; sqt1 Q12809
#313200 Spinal and bulbar muscular atrophy, x-linked 1; smax1 P10275
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#275355 Squamous cell carcinoma, head and neck; hnscc P04637
#187950 Thrombocythemia 1; thcyt1 P40225
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828
#103500 Tietz syndrome O75030
#190300 Tremor, hereditary essential, 1; etm1 P35462
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473
#193510 Waardenburg syndrome, type 2a; ws2a O75030
#610379 West nile virus, susceptibility to P51681
#112100 Yt blood group antigen P22303

KEGG DISEASE (96)

KEGG disease name UniProt
H00038 Malignant melanoma O75030 (related)
O75030 (marker)
P04637 (related)
H00169 Ocular albinism O75030 (related)
H00759 Waardenburg syndrome (WS) O75030 (related)
H01187 Tietz syndrome O75030 (related)
H00016 Oral cancer P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
H00017 Esophageal cancer P00533 (related)
P04637 (related)
P04637 (marker)
P35354 (related)
H00018 Gastric cancer P00533 (related)
P04626 (related)
P04637 (related)
H00022 Bladder cancer P00533 (related)
P04626 (related)
P04637 (related)
H00028 Choriocarcinoma P00533 (related)
P03956 (related)
P04626 (related)
P04637 (related)
H00030 Cervical cancer P00533 (related)
P04626 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
P37231 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00026 Endometrial Cancer P03372 (marker)
P04626 (related)
P04637 (related)
Q92731 (marker)
H00066 Lewy body dementia (LBD) P04062 (related)
H00126 Gaucher disease P04062 (related)
H00426 Defects in the degradation of ganglioside P04062 (related)
H00810 Progressive myoclonic epilepsy (PME) P04062 (related)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00019 Pancreatic cancer P04626 (related)
P04637 (related)
P04637 (marker)
H00027 Ovarian cancer P04626 (related)
P04637 (related)
H00031 Breast cancer P04626 (related)
P04626 (marker)
P04637 (related)
H00046 Cholangiocarcinoma P04626 (related)
P04637 (related)
P35354 (related)
H00004 Chronic myeloid leukemia (CML) P04637 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
H00025 Penile cancer P04637 (related)
P04637 (marker)
P14780 (related)
P35354 (related)
H00029 Vulvar cancer P04637 (related)
H00032 Thyroid cancer P04637 (related)
P37231 (related)
Q06710 (related)
H00033 Adrenal carcinoma P04637 (related)
H00036 Osteosarcoma P04637 (related)
P08684 (marker)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00044 Cancer of the anal canal P04637 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00021 Renal cell carcinoma P04637 (marker)
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
H00079 Asthma P07550 (related)
H00100 Neutropenic disorders P08246 (related)
H00091 T-B+Severe combined immunodeficiencies (SCIDs) P08575 (related)
H00024 Prostate cancer P10275 (related)
H00062 Spinal and bulbar muscular atrophy (SBMA) P10275 (related)
H00608 46,XY disorders of sex development (Disorders in androgen synthesis or action) P10275 (related)
H00609 46,XY disorders of sex development (Other) P10275 (related)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H01205 Coumarin resistance P11712 (related)
H00479 Metaphyseal dysplasias P14780 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
Q06710 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00548 Brunner syndrome P21397 (related)
H00769 Hyperekplexia P23415 (related)
H01031 Orthostatic intolerance (OI) P23975 (related)
H00490 Diaphyseal dysplasia with anemia (Ghosal) P24557 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00409 Type II diabetes mellitus P37231 (related)
H00227 Congenital amegakaryocytic thrombocytopenia (CAMT) P40225 (marker)
H00480 Non-syndromic X-linked mental retardation P50052 (related)
H00552 Glycerol kinase deficiency (GKD) P51843 (related)
H00607 46,XY disorders of sex development (Disorders of gonadal development) P51843 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00720 Long QT syndrome Q12809 (related)
H00725 Short QT syndrome Q12809 (related)
H00838 Congenital fibrosis of the extraocular muscles (CFEOM) Q13509 (related)
H00268 Lissencephaly (LIS) Q71U36 (related)
H00504 Rubinstein-Taybi syndrome Q92793 (related)
H00208 Hyperbilirubinemia Q92887 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)

Diseases related to CTD interactions

108 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D015746 D003078 Abdominal Pain marker/mechanism
10383025
15318531
17497454
D000014 D003078 Abnormalities, Drug-Induced marker/mechanism
4012644
D058186 D003078 Acute Kidney Injury marker/mechanism
16495211
D000505 D003078 Alopecia marker/mechanism
405656
843157
15088997
D000544 D003078 Alzheimer Disease marker/mechanism
9449054
17652827
D000647 D003078 Amnesia marker/mechanism
2924118
D000686 D003078 Amyloidosis marker/mechanism
therapeutic
1499522
1604496
17505274
D000740 D003078 Anemia marker/mechanism
6532622
D000749 D003078 Anemia, Megaloblastic marker/mechanism
15656036
D000783 D003078 Aneurysm marker/mechanism
5760170
D001002 D003078 Anuria marker/mechanism
17497454
D001039 D003078 Aphasia, Broca marker/mechanism
7725894
D001145 D003078 Arrhythmias, Cardiac marker/mechanism
15088997
D015210 D003078 Arthritis, Gouty therapeutic
3701734
5655316
14713183
17497454
20661070
D015535 D003078 Arthritis, Psoriatic therapeutic
17408446
D001259 D003078 Ataxia marker/mechanism
9460408
D001528 D003078 Behcet Syndrome therapeutic
2566048
6788612
9775117
9848464
11087798
12692989
15870978
D001768 D003078 Blister therapeutic
10028001
D001855 D003078 Bone Marrow Diseases marker/mechanism
405656
737005
15088997
D001927 D003078 Brain Diseases marker/mechanism
7403241
D001930 D003078 Brain Injuries marker/mechanism
2924118
D006528 D003078 Carcinoma, Hepatocellular marker/mechanism
8758914
11749691
D002779 D003078 Cholestasis marker/mechanism
3733464
15318531
D003072 D003078 Cognition Disorders marker/mechanism
17135773
17652827
18980205
18992766
D003218 D003078 Condylomata Acuminata therapeutic
843157
D003967 D003078 Diarrhea marker/mechanism
5538601
16240705
17497454
20131255
D004211 D003078 Disseminated Intravascular Coagulation marker/mechanism
4562795
D004244 D003078 Dizziness marker/mechanism
10383025
D004314 D003078 Down Syndrome marker/mechanism
4179378
4182734
D056486 D003078 Drug-Induced Liver Injury marker/mechanism
22331495
D062787 D003078 Drug Overdose marker/mechanism
17505274
D004417 D003078 Dyspnea marker/mechanism
14744269
D004618 D003078 Embolism, Air marker/mechanism
14623787
D004760 D003078 Enterocolitis marker/mechanism
15088997
D010505 D003078 Familial Mediterranean Fever therapeutic
1499522
1575022
9848464
12910572
14632592
16889161
17505274
20661070
D005221 D003078 Fatigue marker/mechanism
20824538
21145509
D005705 D003078 Gallbladder Diseases marker/mechanism
3733464
D005759 D003078 Gastroenteritis marker/mechanism
843157
D005767 D003078 Gastrointestinal Diseases marker/mechanism
10455999
17505274
D005902 D003078 Glaucoma, Open-Angle therapeutic
12446362
D006073 D003078 Gout therapeutic
1064465
2023222
2265497
2360262
3035372
5760170
6071127
7725894
9491303
9848464
11096285
11810174
11876034
12410059
15585444
16669978
17049607
19893064
D020275 D003078 Guillain-Barre Syndrome marker/mechanism
17097509
D006261 D003078 Headache marker/mechanism
10383025
D006470 D003078 Hemorrhage marker/mechanism
405656
D019694 D003078 Hepatitis B, Chronic therapeutic
9701529
D006948 D003078 Hyperkinesis marker/mechanism
2924118
D006955 D003078 Hypernatremia marker/mechanism
10383025
D006973 D003078 Hypertension marker/mechanism
17505274
D033461 D003078 Hyperuricemia therapeutic
6071127
D007010 D003078 Hyponatremia marker/mechanism
405656
D007039 D003078 Hypotrichosis marker/mechanism
17505274
D007249 D003078 Inflammation marker/mechanism
therapeutic
9848464
15318531
D007410 D003078 Intestinal Diseases marker/mechanism
14623787
D007565 D003078 Jaundice marker/mechanism
15318531
D007674 D003078 Kidney Diseases marker/mechanism
3122121
D007859 D003078 Learning Disorders marker/mechanism
11749816
D015479 D003078 Leukemia, Myelomonocytic, Acute marker/mechanism
1064465
D007970 D003078 Leukopenia marker/mechanism
6532622
16240705
D008103 D003078 Liver Cirrhosis therapeutic
23146695
D008107 D003078 Liver Diseases marker/mechanism
2566048
10455999
17497454
D008108 D003078 Liver Diseases, Alcoholic therapeutic
8574231
D017114 D003078 Liver Failure, Acute marker/mechanism
15088997
D008569 D003078 Memory Disorders marker/mechanism
9449054
18992766
D009101 D003078 Multiple Myeloma marker/mechanism
1064465
D009102 D003078 Multiple Organ Failure marker/mechanism
15088997
17497454
17505274
D018908 D003078 Muscle Weakness marker/mechanism
5538601
7725894
8234983
9323377
10904571
11810174
12122515
14632592
14744269
15585444
16669978
17049607
17421021
19143894
20661070
D009133 D003078 Muscular Atrophy marker/mechanism
8234983
D009135 D003078 Muscular Diseases marker/mechanism
1575022
2023222
2046950
2265497
2360262
3035372
3341942
3964122
8614764
9170024
10455999
10686640
11087798
12221632
12371628
12410059
12706115
12910572
15585444
15914514
19893064
20661070
20824538
21145509
D009212 D003078 Myoglobinuria marker/mechanism
1499522
D009222 D003078 Myotonia marker/mechanism
8965841
9533795
D020967 D003078 Myotonic Disorders marker/mechanism
12954545
D009325 D003078 Nausea marker/mechanism
10383025
D009336 D003078 Necrosis marker/mechanism
171611
12576187
D009369 D003078 Neoplasms therapeutic
21472861
D009422 D003078 Nervous System Diseases marker/mechanism
2046950
2360262
3341942
3964122
8234983
D009436 D003078 Neural Tube Defects marker/mechanism
4012644
D009468 D003078 Neuromuscular Diseases marker/mechanism
843157
1466611
1472131
1485821
1604496
2525778
2725561
3035372
7725894
7923972
8965841
9491303
9533795
9809829
10686640
12122515
12371628
12692989
14573738
16148013
16248366
16669978
17097509
17421021
18490798
D009846 D003078 Oliguria marker/mechanism
16240705
17497454
D009896 D003078 Optic Atrophy marker/mechanism
6187703
D009901 D003078 Optic Nerve Diseases marker/mechanism
17421021
D010146 D003078 Pain therapeutic
20131255
D010195 D003078 Pancreatitis marker/mechanism
843157
15088997
D010198 D003078 Pancytopenia marker/mechanism
737005
15088997
15656036
17505274
D010243 D003078 Paralysis marker/mechanism
5538601
D010523 D003078 Peripheral Nervous System Diseases marker/mechanism
9491303
11921069
D011115 D003078 Polyneuropathies marker/mechanism
405656
D011141 D003078 Polyuria marker/mechanism
10383025
16708563
D017119 D003078 Porphyria Cutanea Tarda marker/mechanism
4105790
D011565 D003078 Psoriasis therapeutic
9848464
D011782 D003078 Quadriplegia marker/mechanism
16148013
D012021 D003078 Reflex, Abnormal marker/mechanism
8234983
D051437 D003078 Renal Insufficiency marker/mechanism
405656
1499522
10455999
16240705
17497454
D012131 D003078 Respiratory Insufficiency marker/mechanism
843157
D012206 D003078 Rhabdomyolysis marker/mechanism
14713183
15389652
17497454
D012640 D003078 Seizures marker/mechanism
6509321
6884477
D018805 D003078 Sepsis marker/mechanism
405656
17505274
D012790 D003078 Shwartzman Phenomenon marker/mechanism
4562795
D012871 D003078 Skin Diseases therapeutic
2566048
D013281 D003078 Stomatitis, Aphthous therapeutic
2566048
D020955 D003078 Striatonigral Degeneration marker/mechanism
18564367
D016463 D003078 Sweet Syndrome therapeutic
9848464
D013616 D003078 Tachycardia, Sinus marker/mechanism
17497454
D013921 D003078 Thrombocytopenia marker/mechanism
6532622
16240705
17497454
C536522 D003078 Vacuolar myopathy marker/mechanism
8234983
9394328
11810174
12399640
12954545
16669978
D014786 D003078 Vision Disorders marker/mechanism
17421021
D014806 D003078 Vitamin B 12 Deficiency marker/mechanism
15656036
D014839 D003078 Vomiting marker/mechanism
10383025
16240705
20131255
D015431 D003078 Weight Loss marker/mechanism
405656